-- dump date 20140618_211432 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1338518000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1338518000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1338518000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518000004 Walker A motif; other site 1338518000005 ATP binding site [chemical binding]; other site 1338518000006 Walker B motif; other site 1338518000007 arginine finger; other site 1338518000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1338518000009 DnaA box-binding interface [nucleotide binding]; other site 1338518000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1338518000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1338518000012 putative DNA binding surface [nucleotide binding]; other site 1338518000013 dimer interface [polypeptide binding]; other site 1338518000014 beta-clamp/clamp loader binding surface; other site 1338518000015 beta-clamp/translesion DNA polymerase binding surface; other site 1338518000016 S4 domain; Region: S4_2; pfam13275 1338518000017 recombination protein F; Reviewed; Region: recF; PRK00064 1338518000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1338518000019 Walker A/P-loop; other site 1338518000020 ATP binding site [chemical binding]; other site 1338518000021 Q-loop/lid; other site 1338518000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518000023 ABC transporter signature motif; other site 1338518000024 Walker B; other site 1338518000025 D-loop; other site 1338518000026 H-loop/switch region; other site 1338518000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1338518000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518000029 ATP binding site [chemical binding]; other site 1338518000030 Mg2+ binding site [ion binding]; other site 1338518000031 G-X-G motif; other site 1338518000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1338518000033 anchoring element; other site 1338518000034 dimer interface [polypeptide binding]; other site 1338518000035 ATP binding site [chemical binding]; other site 1338518000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1338518000037 active site 1338518000038 putative metal-binding site [ion binding]; other site 1338518000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1338518000040 DNA gyrase subunit A; Validated; Region: PRK05560 1338518000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1338518000042 CAP-like domain; other site 1338518000043 active site 1338518000044 primary dimer interface [polypeptide binding]; other site 1338518000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1338518000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1338518000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1338518000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1338518000055 active site 1338518000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1338518000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1338518000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1338518000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1338518000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1338518000061 active site 1338518000062 multimer interface [polypeptide binding]; other site 1338518000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1338518000064 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1338518000065 predicted active site [active] 1338518000066 catalytic triad [active] 1338518000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 1338518000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1338518000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1338518000070 dimer interface [polypeptide binding]; other site 1338518000071 active site 1338518000072 motif 1; other site 1338518000073 motif 2; other site 1338518000074 motif 3; other site 1338518000075 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1338518000076 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1338518000077 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1338518000078 Substrate-binding site [chemical binding]; other site 1338518000079 Substrate specificity [chemical binding]; other site 1338518000080 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1338518000081 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1338518000082 Substrate-binding site [chemical binding]; other site 1338518000083 Substrate specificity [chemical binding]; other site 1338518000084 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1338518000085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518000087 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1338518000088 active site 1338518000089 Isochorismatase family; Region: Isochorismatase; pfam00857 1338518000090 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1338518000091 catalytic triad [active] 1338518000092 conserved cis-peptide bond; other site 1338518000093 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1338518000094 nucleoside/Zn binding site; other site 1338518000095 dimer interface [polypeptide binding]; other site 1338518000096 catalytic motif [active] 1338518000097 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1338518000098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518000099 Walker A motif; other site 1338518000100 ATP binding site [chemical binding]; other site 1338518000101 Walker B motif; other site 1338518000102 arginine finger; other site 1338518000103 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1338518000104 hypothetical protein; Validated; Region: PRK00153 1338518000105 recombination protein RecR; Reviewed; Region: recR; PRK00076 1338518000106 RecR protein; Region: RecR; pfam02132 1338518000107 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1338518000108 putative active site [active] 1338518000109 putative metal-binding site [ion binding]; other site 1338518000110 tetramer interface [polypeptide binding]; other site 1338518000111 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1338518000112 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 1338518000113 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1338518000114 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1338518000115 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1338518000116 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1338518000117 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1338518000118 homodimer interface [polypeptide binding]; other site 1338518000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518000120 catalytic residue [active] 1338518000121 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1338518000122 thymidylate kinase; Validated; Region: tmk; PRK00698 1338518000123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1338518000124 TMP-binding site; other site 1338518000125 ATP-binding site [chemical binding]; other site 1338518000126 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1338518000127 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1338518000128 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1338518000129 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1338518000130 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1338518000131 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1338518000132 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1338518000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518000134 S-adenosylmethionine binding site [chemical binding]; other site 1338518000135 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1338518000136 GIY-YIG motif/motif A; other site 1338518000137 putative active site [active] 1338518000138 putative metal binding site [ion binding]; other site 1338518000139 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1338518000140 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1338518000141 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1338518000142 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1338518000143 active site 1338518000144 HIGH motif; other site 1338518000145 KMSKS motif; other site 1338518000146 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1338518000147 tRNA binding surface [nucleotide binding]; other site 1338518000148 anticodon binding site; other site 1338518000149 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1338518000150 dimer interface [polypeptide binding]; other site 1338518000151 putative tRNA-binding site [nucleotide binding]; other site 1338518000152 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1338518000153 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1338518000154 active site 1338518000155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1338518000156 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1338518000157 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1338518000158 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1338518000159 G5 domain; Region: G5; pfam07501 1338518000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1338518000161 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1338518000162 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1338518000163 putative active site [active] 1338518000164 putative metal binding site [ion binding]; other site 1338518000165 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1338518000166 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1338518000167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518000168 S-adenosylmethionine binding site [chemical binding]; other site 1338518000169 YabG peptidase U57; Region: Peptidase_U57; pfam05582 1338518000170 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1338518000171 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1338518000172 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1338518000173 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1338518000174 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1338518000175 pur operon repressor; Provisional; Region: PRK09213 1338518000176 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1338518000177 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1338518000178 active site 1338518000179 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1338518000180 homotrimer interaction site [polypeptide binding]; other site 1338518000181 putative active site [active] 1338518000182 regulatory protein SpoVG; Reviewed; Region: PRK13259 1338518000183 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1338518000184 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1338518000185 Substrate binding site; other site 1338518000186 Mg++ binding site; other site 1338518000187 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1338518000188 active site 1338518000189 substrate binding site [chemical binding]; other site 1338518000190 CoA binding site [chemical binding]; other site 1338518000191 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1338518000192 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1338518000193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1338518000194 active site 1338518000195 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1338518000196 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1338518000197 5S rRNA interface [nucleotide binding]; other site 1338518000198 CTC domain interface [polypeptide binding]; other site 1338518000199 L16 interface [polypeptide binding]; other site 1338518000200 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1338518000201 putative active site [active] 1338518000202 catalytic residue [active] 1338518000203 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1338518000204 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1338518000205 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1338518000206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518000207 ATP binding site [chemical binding]; other site 1338518000208 putative Mg++ binding site [ion binding]; other site 1338518000209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518000210 nucleotide binding region [chemical binding]; other site 1338518000211 ATP-binding site [chemical binding]; other site 1338518000212 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1338518000213 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1338518000214 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1338518000215 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1338518000216 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1338518000217 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1338518000218 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1338518000219 putative SAM binding site [chemical binding]; other site 1338518000220 putative homodimer interface [polypeptide binding]; other site 1338518000221 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1338518000222 homodimer interface [polypeptide binding]; other site 1338518000223 metal binding site [ion binding]; metal-binding site 1338518000224 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1338518000225 homodimer interface [polypeptide binding]; other site 1338518000226 active site 1338518000227 putative chemical substrate binding site [chemical binding]; other site 1338518000228 metal binding site [ion binding]; metal-binding site 1338518000229 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1338518000230 RNA binding surface [nucleotide binding]; other site 1338518000231 sporulation protein YabP; Region: spore_yabP; TIGR02892 1338518000232 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1338518000233 hypothetical protein; Provisional; Region: PRK08582 1338518000234 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1338518000235 RNA binding site [nucleotide binding]; other site 1338518000236 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1338518000237 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1338518000238 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1338518000239 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1338518000240 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1338518000241 metal ion-dependent adhesion site (MIDAS); other site 1338518000242 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1338518000243 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1338518000244 active site 1338518000245 ATP binding site [chemical binding]; other site 1338518000246 substrate binding site [chemical binding]; other site 1338518000247 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1338518000248 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1338518000249 Ligand Binding Site [chemical binding]; other site 1338518000250 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1338518000251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1338518000252 active site 1338518000253 FtsH Extracellular; Region: FtsH_ext; pfam06480 1338518000254 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1338518000255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518000256 Walker A motif; other site 1338518000257 ATP binding site [chemical binding]; other site 1338518000258 Walker B motif; other site 1338518000259 arginine finger; other site 1338518000260 Peptidase family M41; Region: Peptidase_M41; pfam01434 1338518000261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1338518000262 nucleotide binding site [chemical binding]; other site 1338518000263 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1338518000264 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1338518000265 dimerization interface [polypeptide binding]; other site 1338518000266 domain crossover interface; other site 1338518000267 redox-dependent activation switch; other site 1338518000268 SurA N-terminal domain; Region: SurA_N_3; cl07813 1338518000269 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1338518000270 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1338518000271 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1338518000272 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1338518000273 dimer interface [polypeptide binding]; other site 1338518000274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518000275 catalytic residue [active] 1338518000276 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1338518000277 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1338518000278 glutamine binding [chemical binding]; other site 1338518000279 catalytic triad [active] 1338518000280 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1338518000281 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1338518000282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518000283 catalytic residue [active] 1338518000284 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1338518000285 homooctamer interface [polypeptide binding]; other site 1338518000286 active site 1338518000287 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1338518000288 catalytic center binding site [active] 1338518000289 ATP binding site [chemical binding]; other site 1338518000290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518000291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518000292 non-specific DNA binding site [nucleotide binding]; other site 1338518000293 salt bridge; other site 1338518000294 sequence-specific DNA binding site [nucleotide binding]; other site 1338518000295 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1338518000296 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1338518000297 FMN binding site [chemical binding]; other site 1338518000298 active site 1338518000299 catalytic residues [active] 1338518000300 substrate binding site [chemical binding]; other site 1338518000301 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1338518000302 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1338518000303 dimer interface [polypeptide binding]; other site 1338518000304 putative anticodon binding site; other site 1338518000305 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1338518000306 motif 1; other site 1338518000307 active site 1338518000308 motif 2; other site 1338518000309 motif 3; other site 1338518000310 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1338518000311 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1338518000312 UvrB/uvrC motif; Region: UVR; pfam02151 1338518000313 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1338518000314 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1338518000315 ADP binding site [chemical binding]; other site 1338518000316 phosphagen binding site; other site 1338518000317 substrate specificity loop; other site 1338518000318 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1338518000319 Clp amino terminal domain; Region: Clp_N; pfam02861 1338518000320 Clp amino terminal domain; Region: Clp_N; pfam02861 1338518000321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518000322 Walker A motif; other site 1338518000323 ATP binding site [chemical binding]; other site 1338518000324 Walker B motif; other site 1338518000325 arginine finger; other site 1338518000326 UvrB/uvrC motif; Region: UVR; pfam02151 1338518000327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518000328 Walker A motif; other site 1338518000329 ATP binding site [chemical binding]; other site 1338518000330 Walker B motif; other site 1338518000331 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1338518000332 DNA repair protein RadA; Provisional; Region: PRK11823 1338518000333 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1338518000334 Walker A motif/ATP binding site; other site 1338518000335 ATP binding site [chemical binding]; other site 1338518000336 Walker B motif; other site 1338518000337 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1338518000338 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1338518000339 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1338518000340 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1338518000341 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1338518000342 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1338518000343 putative active site [active] 1338518000344 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1338518000345 substrate binding site; other site 1338518000346 dimer interface; other site 1338518000347 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1338518000348 homotrimer interaction site [polypeptide binding]; other site 1338518000349 zinc binding site [ion binding]; other site 1338518000350 CDP-binding sites; other site 1338518000351 serine O-acetyltransferase; Region: cysE; TIGR01172 1338518000352 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1338518000353 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1338518000354 trimer interface [polypeptide binding]; other site 1338518000355 active site 1338518000356 substrate binding site [chemical binding]; other site 1338518000357 CoA binding site [chemical binding]; other site 1338518000358 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1338518000359 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1338518000360 active site 1338518000361 HIGH motif; other site 1338518000362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1338518000363 KMSKS motif; other site 1338518000364 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1338518000365 tRNA binding surface [nucleotide binding]; other site 1338518000366 anticodon binding site; other site 1338518000367 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1338518000368 active site 1338518000369 metal binding site [ion binding]; metal-binding site 1338518000370 dimerization interface [polypeptide binding]; other site 1338518000371 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1338518000372 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1338518000373 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1338518000374 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1338518000375 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1338518000376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518000377 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1338518000378 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1338518000379 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1338518000380 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1338518000381 putative homodimer interface [polypeptide binding]; other site 1338518000382 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1338518000383 heterodimer interface [polypeptide binding]; other site 1338518000384 homodimer interface [polypeptide binding]; other site 1338518000385 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1338518000386 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1338518000387 23S rRNA interface [nucleotide binding]; other site 1338518000388 L7/L12 interface [polypeptide binding]; other site 1338518000389 putative thiostrepton binding site; other site 1338518000390 L25 interface [polypeptide binding]; other site 1338518000391 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1338518000392 mRNA/rRNA interface [nucleotide binding]; other site 1338518000393 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1338518000394 23S rRNA interface [nucleotide binding]; other site 1338518000395 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1338518000396 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1338518000397 core dimer interface [polypeptide binding]; other site 1338518000398 peripheral dimer interface [polypeptide binding]; other site 1338518000399 L10 interface [polypeptide binding]; other site 1338518000400 L11 interface [polypeptide binding]; other site 1338518000401 putative EF-Tu interaction site [polypeptide binding]; other site 1338518000402 putative EF-G interaction site [polypeptide binding]; other site 1338518000403 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1338518000404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518000405 S-adenosylmethionine binding site [chemical binding]; other site 1338518000406 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1338518000407 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1338518000408 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1338518000409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1338518000410 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1338518000411 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1338518000412 RPB1 interaction site [polypeptide binding]; other site 1338518000413 RPB10 interaction site [polypeptide binding]; other site 1338518000414 RPB11 interaction site [polypeptide binding]; other site 1338518000415 RPB3 interaction site [polypeptide binding]; other site 1338518000416 RPB12 interaction site [polypeptide binding]; other site 1338518000417 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1338518000418 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1338518000419 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1338518000420 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1338518000421 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1338518000422 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1338518000423 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1338518000424 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1338518000425 G-loop; other site 1338518000426 DNA binding site [nucleotide binding] 1338518000427 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1338518000428 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1338518000429 S17 interaction site [polypeptide binding]; other site 1338518000430 S8 interaction site; other site 1338518000431 16S rRNA interaction site [nucleotide binding]; other site 1338518000432 streptomycin interaction site [chemical binding]; other site 1338518000433 23S rRNA interaction site [nucleotide binding]; other site 1338518000434 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1338518000435 30S ribosomal protein S7; Validated; Region: PRK05302 1338518000436 elongation factor G; Reviewed; Region: PRK00007 1338518000437 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1338518000438 G1 box; other site 1338518000439 putative GEF interaction site [polypeptide binding]; other site 1338518000440 GTP/Mg2+ binding site [chemical binding]; other site 1338518000441 Switch I region; other site 1338518000442 G2 box; other site 1338518000443 G3 box; other site 1338518000444 Switch II region; other site 1338518000445 G4 box; other site 1338518000446 G5 box; other site 1338518000447 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1338518000448 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1338518000449 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1338518000450 elongation factor Tu; Reviewed; Region: PRK00049 1338518000451 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1338518000452 G1 box; other site 1338518000453 GEF interaction site [polypeptide binding]; other site 1338518000454 GTP/Mg2+ binding site [chemical binding]; other site 1338518000455 Switch I region; other site 1338518000456 G2 box; other site 1338518000457 G3 box; other site 1338518000458 Switch II region; other site 1338518000459 G4 box; other site 1338518000460 G5 box; other site 1338518000461 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1338518000462 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1338518000463 Antibiotic Binding Site [chemical binding]; other site 1338518000464 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1338518000465 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1338518000466 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1338518000467 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1338518000468 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1338518000469 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1338518000470 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1338518000471 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1338518000472 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1338518000473 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1338518000474 putative translocon binding site; other site 1338518000475 protein-rRNA interface [nucleotide binding]; other site 1338518000476 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1338518000477 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1338518000478 G-X-X-G motif; other site 1338518000479 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1338518000480 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1338518000481 23S rRNA interface [nucleotide binding]; other site 1338518000482 5S rRNA interface [nucleotide binding]; other site 1338518000483 putative antibiotic binding site [chemical binding]; other site 1338518000484 L25 interface [polypeptide binding]; other site 1338518000485 L27 interface [polypeptide binding]; other site 1338518000486 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1338518000487 23S rRNA interface [nucleotide binding]; other site 1338518000488 putative translocon interaction site; other site 1338518000489 signal recognition particle (SRP54) interaction site; other site 1338518000490 L23 interface [polypeptide binding]; other site 1338518000491 trigger factor interaction site; other site 1338518000492 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1338518000493 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1338518000494 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1338518000495 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1338518000496 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1338518000497 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1338518000498 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1338518000499 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1338518000500 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1338518000501 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1338518000502 5S rRNA interface [nucleotide binding]; other site 1338518000503 L27 interface [polypeptide binding]; other site 1338518000504 23S rRNA interface [nucleotide binding]; other site 1338518000505 L5 interface [polypeptide binding]; other site 1338518000506 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1338518000507 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1338518000508 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1338518000509 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1338518000510 23S rRNA binding site [nucleotide binding]; other site 1338518000511 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1338518000512 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1338518000513 SecY translocase; Region: SecY; pfam00344 1338518000514 adenylate kinase; Reviewed; Region: adk; PRK00279 1338518000515 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1338518000516 AMP-binding site [chemical binding]; other site 1338518000517 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1338518000518 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1338518000519 active site 1338518000520 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1338518000521 rRNA binding site [nucleotide binding]; other site 1338518000522 predicted 30S ribosome binding site; other site 1338518000523 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1338518000524 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1338518000525 30S ribosomal protein S11; Validated; Region: PRK05309 1338518000526 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1338518000527 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1338518000528 alphaNTD homodimer interface [polypeptide binding]; other site 1338518000529 alphaNTD - beta interaction site [polypeptide binding]; other site 1338518000530 alphaNTD - beta' interaction site [polypeptide binding]; other site 1338518000531 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1338518000532 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1338518000533 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1338518000534 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1338518000535 Walker A/P-loop; other site 1338518000536 ATP binding site [chemical binding]; other site 1338518000537 Q-loop/lid; other site 1338518000538 ABC transporter signature motif; other site 1338518000539 Walker B; other site 1338518000540 D-loop; other site 1338518000541 H-loop/switch region; other site 1338518000542 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1338518000543 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1338518000544 Walker A/P-loop; other site 1338518000545 ATP binding site [chemical binding]; other site 1338518000546 Q-loop/lid; other site 1338518000547 ABC transporter signature motif; other site 1338518000548 Walker B; other site 1338518000549 D-loop; other site 1338518000550 H-loop/switch region; other site 1338518000551 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1338518000552 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1338518000553 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1338518000554 dimerization interface 3.5A [polypeptide binding]; other site 1338518000555 active site 1338518000556 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1338518000557 23S rRNA interface [nucleotide binding]; other site 1338518000558 L3 interface [polypeptide binding]; other site 1338518000559 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1338518000560 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1338518000561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518000562 S-adenosylmethionine binding site [chemical binding]; other site 1338518000563 DinB family; Region: DinB; cl17821 1338518000564 DinB superfamily; Region: DinB_2; pfam12867 1338518000565 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1338518000566 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1338518000567 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1338518000568 active site 1338518000569 metal binding site [ion binding]; metal-binding site 1338518000570 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1338518000571 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1338518000572 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1338518000573 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1338518000574 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1338518000575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518000576 putative substrate translocation pore; other site 1338518000577 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1338518000578 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518000579 inhibitor-cofactor binding pocket; inhibition site 1338518000580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518000581 catalytic residue [active] 1338518000582 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1338518000583 active site 1338518000584 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1338518000585 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1338518000586 NAD(P) binding site [chemical binding]; other site 1338518000587 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1338518000588 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1338518000589 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1338518000590 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1338518000591 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1338518000592 Sodium Bile acid symporter family; Region: SBF; cl17470 1338518000593 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1338518000594 Putative esterase; Region: Esterase; pfam00756 1338518000595 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1338518000596 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518000597 ABC-ATPase subunit interface; other site 1338518000598 dimer interface [polypeptide binding]; other site 1338518000599 putative PBP binding regions; other site 1338518000600 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1338518000601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518000602 ABC-ATPase subunit interface; other site 1338518000603 dimer interface [polypeptide binding]; other site 1338518000604 putative PBP binding regions; other site 1338518000605 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1338518000606 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1338518000607 intersubunit interface [polypeptide binding]; other site 1338518000608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518000609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1338518000610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518000611 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1338518000612 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1338518000613 intersubunit interface [polypeptide binding]; other site 1338518000614 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1338518000615 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1338518000616 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1338518000617 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1338518000618 putative periplasmic esterase; Provisional; Region: PRK03642 1338518000619 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1338518000620 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1338518000621 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1338518000622 active site turn [active] 1338518000623 phosphorylation site [posttranslational modification] 1338518000624 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1338518000625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1338518000626 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1338518000627 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1338518000628 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518000629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518000630 DNA binding residues [nucleotide binding] 1338518000631 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1338518000632 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1338518000633 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1338518000634 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1338518000635 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1338518000636 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1338518000637 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1338518000638 active site 1338518000639 substrate binding site [chemical binding]; other site 1338518000640 metal binding site [ion binding]; metal-binding site 1338518000641 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1338518000642 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1338518000643 glutaminase active site [active] 1338518000644 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1338518000645 dimer interface [polypeptide binding]; other site 1338518000646 active site 1338518000647 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1338518000648 dimer interface [polypeptide binding]; other site 1338518000649 active site 1338518000650 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1338518000651 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1338518000652 Walker A/P-loop; other site 1338518000653 ATP binding site [chemical binding]; other site 1338518000654 Q-loop/lid; other site 1338518000655 ABC transporter signature motif; other site 1338518000656 Walker B; other site 1338518000657 D-loop; other site 1338518000658 H-loop/switch region; other site 1338518000659 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1338518000660 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1338518000661 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518000662 Condensation domain; Region: Condensation; pfam00668 1338518000663 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1338518000664 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1338518000665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1338518000666 CoA binding site [chemical binding]; other site 1338518000667 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518000668 Condensation domain; Region: Condensation; pfam00668 1338518000669 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1338518000670 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1338518000671 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1338518000672 acyl-activating enzyme (AAE) consensus motif; other site 1338518000673 AMP binding site [chemical binding]; other site 1338518000674 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518000675 Condensation domain; Region: Condensation; pfam00668 1338518000676 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1338518000677 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1338518000679 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1338518000680 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1338518000681 acyl-activating enzyme (AAE) consensus motif; other site 1338518000682 AMP binding site [chemical binding]; other site 1338518000683 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518000684 Condensation domain; Region: Condensation; pfam00668 1338518000685 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1338518000686 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1338518000687 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1338518000688 acyl-activating enzyme (AAE) consensus motif; other site 1338518000689 AMP binding site [chemical binding]; other site 1338518000690 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518000691 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1338518000692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518000693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518000694 active site 1338518000695 phosphorylation site [posttranslational modification] 1338518000696 intermolecular recognition site; other site 1338518000697 dimerization interface [polypeptide binding]; other site 1338518000698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518000699 DNA binding site [nucleotide binding] 1338518000700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518000701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518000702 ATP binding site [chemical binding]; other site 1338518000703 Mg2+ binding site [ion binding]; other site 1338518000704 G-X-G motif; other site 1338518000705 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1338518000706 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1338518000707 Walker A/P-loop; other site 1338518000708 ATP binding site [chemical binding]; other site 1338518000709 Q-loop/lid; other site 1338518000710 ABC transporter signature motif; other site 1338518000711 Walker B; other site 1338518000712 D-loop; other site 1338518000713 H-loop/switch region; other site 1338518000714 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1338518000715 Protein export membrane protein; Region: SecD_SecF; cl14618 1338518000716 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1338518000717 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518000718 MarR family; Region: MarR; pfam01047 1338518000719 putative transport protein YifK; Provisional; Region: PRK10746 1338518000720 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1338518000721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518000722 active site 1338518000723 motif I; other site 1338518000724 motif II; other site 1338518000725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1338518000726 Histidine kinase; Region: HisKA_3; pfam07730 1338518000727 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1338518000728 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518000729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518000730 active site 1338518000731 phosphorylation site [posttranslational modification] 1338518000732 intermolecular recognition site; other site 1338518000733 dimerization interface [polypeptide binding]; other site 1338518000734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518000735 DNA binding residues [nucleotide binding] 1338518000736 dimerization interface [polypeptide binding]; other site 1338518000737 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1338518000738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518000739 Walker A/P-loop; other site 1338518000740 ATP binding site [chemical binding]; other site 1338518000741 Q-loop/lid; other site 1338518000742 ABC transporter signature motif; other site 1338518000743 Walker B; other site 1338518000744 D-loop; other site 1338518000745 H-loop/switch region; other site 1338518000746 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1338518000747 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1338518000748 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1338518000749 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1338518000750 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1338518000751 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1338518000752 active site 1338518000753 catalytic site [active] 1338518000754 metal binding site [ion binding]; metal-binding site 1338518000755 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1338518000756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518000757 putative substrate translocation pore; other site 1338518000758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518000759 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1338518000760 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1338518000761 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1338518000762 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1338518000763 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1338518000764 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1338518000765 active site 1338518000766 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518000767 non-specific DNA binding site [nucleotide binding]; other site 1338518000768 salt bridge; other site 1338518000769 sequence-specific DNA binding site [nucleotide binding]; other site 1338518000770 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1338518000771 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1338518000772 active site 1338518000773 NAD binding site [chemical binding]; other site 1338518000774 metal binding site [ion binding]; metal-binding site 1338518000775 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1338518000776 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1338518000777 ATP-grasp domain; Region: ATP-grasp; pfam02222 1338518000778 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1338518000779 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1338518000780 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1338518000781 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1338518000782 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1338518000783 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1338518000784 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1338518000785 active site residue [active] 1338518000786 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1338518000787 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1338518000788 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1338518000789 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1338518000790 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1338518000791 homodimer interface [polypeptide binding]; other site 1338518000792 substrate-cofactor binding pocket; other site 1338518000793 catalytic residue [active] 1338518000794 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1338518000795 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1338518000796 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1338518000797 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1338518000798 glutaminase; Reviewed; Region: PRK12357 1338518000799 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1338518000800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518000801 Response regulator receiver domain; Region: Response_reg; pfam00072 1338518000802 active site 1338518000803 phosphorylation site [posttranslational modification] 1338518000804 intermolecular recognition site; other site 1338518000805 dimerization interface [polypeptide binding]; other site 1338518000806 YcbB domain; Region: YcbB; pfam08664 1338518000807 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1338518000808 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1338518000809 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1338518000810 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1338518000811 dimer interface [polypeptide binding]; other site 1338518000812 FMN binding site [chemical binding]; other site 1338518000813 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1338518000814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518000815 Zn binding site [ion binding]; other site 1338518000816 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1338518000817 Zn binding site [ion binding]; other site 1338518000818 Predicted membrane protein [Function unknown]; Region: COG2259 1338518000819 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1338518000820 catalytic residues [active] 1338518000821 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1338518000822 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1338518000823 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1338518000824 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1338518000825 putative active site [active] 1338518000826 putative metal binding site [ion binding]; other site 1338518000827 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1338518000828 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1338518000829 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1338518000830 putative substrate binding pocket [chemical binding]; other site 1338518000831 AC domain interface; other site 1338518000832 catalytic triad [active] 1338518000833 AB domain interface; other site 1338518000834 interchain disulfide; other site 1338518000835 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1338518000836 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1338518000837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1338518000838 catalytic residue [active] 1338518000839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518000840 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1338518000841 putative substrate translocation pore; other site 1338518000842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518000843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518000844 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1338518000845 active site 1338518000846 homotetramer interface [polypeptide binding]; other site 1338518000847 homodimer interface [polypeptide binding]; other site 1338518000848 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1338518000849 Lipase (class 2); Region: Lipase_2; pfam01674 1338518000850 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1338518000851 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1338518000852 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1338518000853 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1338518000854 active site 1338518000855 catalytic tetrad [active] 1338518000856 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1338518000857 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1338518000858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518000859 binding surface 1338518000860 TPR motif; other site 1338518000861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1338518000862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518000863 TPR motif; other site 1338518000864 binding surface 1338518000865 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1338518000866 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1338518000867 NAD binding site [chemical binding]; other site 1338518000868 homodimer interface [polypeptide binding]; other site 1338518000869 active site 1338518000870 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1338518000871 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1338518000872 Ca binding site [ion binding]; other site 1338518000873 active site 1338518000874 catalytic site [active] 1338518000875 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1338518000876 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1338518000877 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1338518000878 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518000879 ABC-ATPase subunit interface; other site 1338518000880 dimer interface [polypeptide binding]; other site 1338518000881 putative PBP binding regions; other site 1338518000882 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1338518000883 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1338518000884 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1338518000885 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1338518000886 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1338518000887 putative metal binding site [ion binding]; other site 1338518000888 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1338518000889 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1338518000890 putative metal binding site [ion binding]; other site 1338518000891 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1338518000892 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1338518000893 putative metal binding site [ion binding]; other site 1338518000894 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1338518000895 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1338518000896 benzoate transport; Region: 2A0115; TIGR00895 1338518000897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518000898 putative substrate translocation pore; other site 1338518000899 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1338518000900 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1338518000901 Walker A/P-loop; other site 1338518000902 ATP binding site [chemical binding]; other site 1338518000903 Q-loop/lid; other site 1338518000904 ABC transporter signature motif; other site 1338518000905 Walker B; other site 1338518000906 D-loop; other site 1338518000907 H-loop/switch region; other site 1338518000908 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1338518000909 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1338518000910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518000911 dimer interface [polypeptide binding]; other site 1338518000912 conserved gate region; other site 1338518000913 putative PBP binding loops; other site 1338518000914 ABC-ATPase subunit interface; other site 1338518000915 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1338518000916 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1338518000917 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1338518000918 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1338518000919 amidohydrolase; Region: amidohydrolases; TIGR01891 1338518000920 metal binding site [ion binding]; metal-binding site 1338518000921 putative dimer interface [polypeptide binding]; other site 1338518000922 Predicted membrane protein [Function unknown]; Region: COG1288 1338518000923 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1338518000924 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 1338518000925 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1338518000926 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1338518000927 active site 1338518000928 Ca binding site [ion binding]; other site 1338518000929 catalytic site [active] 1338518000930 Aamy_C domain; Region: Aamy_C; smart00632 1338518000931 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1338518000932 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1338518000933 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1338518000934 NAD binding site [chemical binding]; other site 1338518000935 dimer interface [polypeptide binding]; other site 1338518000936 substrate binding site [chemical binding]; other site 1338518000937 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1338518000938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518000939 putative substrate translocation pore; other site 1338518000940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518000941 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518000942 MarR family; Region: MarR; pfam01047 1338518000943 LysE type translocator; Region: LysE; pfam01810 1338518000944 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1338518000945 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1338518000946 Spore germination protein; Region: Spore_permease; cl17796 1338518000947 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1338518000948 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1338518000949 NAD+ synthetase; Region: nadE; TIGR00552 1338518000950 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1338518000951 homodimer interface [polypeptide binding]; other site 1338518000952 NAD binding pocket [chemical binding]; other site 1338518000953 ATP binding pocket [chemical binding]; other site 1338518000954 Mg binding site [ion binding]; other site 1338518000955 active-site loop [active] 1338518000956 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1338518000957 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1338518000958 AAA domain; Region: AAA_18; pfam13238 1338518000959 active site 1338518000960 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1338518000961 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1338518000962 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1338518000963 shikimate kinase; Reviewed; Region: aroK; PRK00131 1338518000964 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1338518000965 ADP binding site [chemical binding]; other site 1338518000966 magnesium binding site [ion binding]; other site 1338518000967 putative shikimate binding site; other site 1338518000968 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1338518000969 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1338518000970 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1338518000971 Proline dehydrogenase; Region: Pro_dh; pfam01619 1338518000972 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1338518000973 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1338518000974 Glutamate binding site [chemical binding]; other site 1338518000975 homodimer interface [polypeptide binding]; other site 1338518000976 NAD binding site [chemical binding]; other site 1338518000977 catalytic residues [active] 1338518000978 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1338518000979 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1338518000980 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1338518000981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1338518000982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518000983 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1338518000984 [2Fe-2S] cluster binding site [ion binding]; other site 1338518000985 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1338518000986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518000987 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1338518000988 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1338518000989 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1338518000990 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1338518000991 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1338518000992 [4Fe-4S] binding site [ion binding]; other site 1338518000993 molybdopterin cofactor binding site; other site 1338518000994 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1338518000995 molybdopterin cofactor binding site; other site 1338518000996 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1338518000997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1338518000998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518000999 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1338518001000 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1338518001001 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1338518001002 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1338518001003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001004 putative substrate translocation pore; other site 1338518001005 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1338518001006 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1338518001007 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1338518001008 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1338518001009 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1338518001010 NAD binding site [chemical binding]; other site 1338518001011 catalytic Zn binding site [ion binding]; other site 1338518001012 structural Zn binding site [ion binding]; other site 1338518001013 RDD family; Region: RDD; pfam06271 1338518001014 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1338518001015 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1338518001016 beta-galactosidase; Region: BGL; TIGR03356 1338518001017 Competence protein J (ComJ); Region: ComJ; pfam11033 1338518001018 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1338518001019 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1338518001020 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1338518001021 tetramer interface [polypeptide binding]; other site 1338518001022 active site 1338518001023 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1338518001024 active site 1338518001025 dimer interface [polypeptide binding]; other site 1338518001026 magnesium binding site [ion binding]; other site 1338518001027 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1338518001028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518001029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518001030 homodimer interface [polypeptide binding]; other site 1338518001031 catalytic residue [active] 1338518001032 YcxB-like protein; Region: YcxB; pfam14317 1338518001033 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1338518001034 EamA-like transporter family; Region: EamA; pfam00892 1338518001035 EamA-like transporter family; Region: EamA; pfam00892 1338518001036 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1338518001037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518001038 DNA-binding site [nucleotide binding]; DNA binding site 1338518001039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518001040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518001041 homodimer interface [polypeptide binding]; other site 1338518001042 catalytic residue [active] 1338518001043 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1338518001044 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1338518001045 Predicted membrane protein [Function unknown]; Region: COG2364 1338518001046 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518001047 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1338518001048 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1338518001049 Walker A/P-loop; other site 1338518001050 ATP binding site [chemical binding]; other site 1338518001051 Q-loop/lid; other site 1338518001052 ABC transporter signature motif; other site 1338518001053 Walker B; other site 1338518001054 D-loop; other site 1338518001055 H-loop/switch region; other site 1338518001056 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1338518001057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518001058 dimer interface [polypeptide binding]; other site 1338518001059 conserved gate region; other site 1338518001060 putative PBP binding loops; other site 1338518001061 ABC-ATPase subunit interface; other site 1338518001062 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1338518001063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1338518001064 substrate binding pocket [chemical binding]; other site 1338518001065 membrane-bound complex binding site; other site 1338518001066 hinge residues; other site 1338518001067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518001068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518001069 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518001070 dimerization interface [polypeptide binding]; other site 1338518001071 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1338518001072 Flavoprotein; Region: Flavoprotein; pfam02441 1338518001073 UbiD family decarboxylase; Region: TIGR00148 1338518001074 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1338518001075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001076 putative substrate translocation pore; other site 1338518001077 POT family; Region: PTR2; pfam00854 1338518001078 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1338518001079 Right handed beta helix region; Region: Beta_helix; pfam13229 1338518001080 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1338518001081 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1338518001082 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1338518001083 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1338518001084 Spore germination protein; Region: Spore_permease; pfam03845 1338518001085 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1338518001086 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1338518001087 active site 1338518001088 non-prolyl cis peptide bond; other site 1338518001089 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1338518001090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1338518001091 substrate binding pocket [chemical binding]; other site 1338518001092 membrane-bound complex binding site; other site 1338518001093 hinge residues; other site 1338518001094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518001095 dimer interface [polypeptide binding]; other site 1338518001096 conserved gate region; other site 1338518001097 putative PBP binding loops; other site 1338518001098 ABC-ATPase subunit interface; other site 1338518001099 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1338518001100 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1338518001101 Walker A/P-loop; other site 1338518001102 ATP binding site [chemical binding]; other site 1338518001103 Q-loop/lid; other site 1338518001104 ABC transporter signature motif; other site 1338518001105 Walker B; other site 1338518001106 D-loop; other site 1338518001107 H-loop/switch region; other site 1338518001108 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1338518001109 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1338518001110 metal binding site [ion binding]; metal-binding site 1338518001111 dimer interface [polypeptide binding]; other site 1338518001112 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1338518001113 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1338518001114 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1338518001115 Walker A/P-loop; other site 1338518001116 ATP binding site [chemical binding]; other site 1338518001117 Q-loop/lid; other site 1338518001118 ABC transporter signature motif; other site 1338518001119 Walker B; other site 1338518001120 D-loop; other site 1338518001121 H-loop/switch region; other site 1338518001122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1338518001123 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1338518001124 FtsX-like permease family; Region: FtsX; pfam02687 1338518001125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518001126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518001127 active site 1338518001128 phosphorylation site [posttranslational modification] 1338518001129 intermolecular recognition site; other site 1338518001130 dimerization interface [polypeptide binding]; other site 1338518001131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518001132 DNA binding site [nucleotide binding] 1338518001133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1338518001134 binding surface 1338518001135 TPR motif; other site 1338518001136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518001137 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518001138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518001139 TPR motif; other site 1338518001140 binding surface 1338518001141 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518001142 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1338518001143 aspartate kinase; Reviewed; Region: PRK09034 1338518001144 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1338518001145 putative catalytic residues [active] 1338518001146 putative nucleotide binding site [chemical binding]; other site 1338518001147 putative aspartate binding site [chemical binding]; other site 1338518001148 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1338518001149 allosteric regulatory residue; other site 1338518001150 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1338518001151 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1338518001152 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518001153 ABC-ATPase subunit interface; other site 1338518001154 dimer interface [polypeptide binding]; other site 1338518001155 putative PBP binding regions; other site 1338518001156 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518001157 ABC-ATPase subunit interface; other site 1338518001158 dimer interface [polypeptide binding]; other site 1338518001159 putative PBP binding regions; other site 1338518001160 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1338518001161 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1338518001162 Walker A/P-loop; other site 1338518001163 ATP binding site [chemical binding]; other site 1338518001164 Q-loop/lid; other site 1338518001165 ABC transporter signature motif; other site 1338518001166 Walker B; other site 1338518001167 D-loop; other site 1338518001168 H-loop/switch region; other site 1338518001169 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1338518001170 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1338518001171 putative ligand binding residues [chemical binding]; other site 1338518001172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518001174 putative substrate translocation pore; other site 1338518001175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518001177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518001178 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1338518001179 dimer interface [polypeptide binding]; other site 1338518001180 FMN binding site [chemical binding]; other site 1338518001181 NADPH bind site [chemical binding]; other site 1338518001182 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1338518001183 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518001184 dimerization interface [polypeptide binding]; other site 1338518001185 putative DNA binding site [nucleotide binding]; other site 1338518001186 putative Zn2+ binding site [ion binding]; other site 1338518001187 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1338518001188 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518001189 DNA-binding site [nucleotide binding]; DNA binding site 1338518001190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518001191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518001192 homodimer interface [polypeptide binding]; other site 1338518001193 catalytic residue [active] 1338518001194 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1338518001195 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518001196 inhibitor-cofactor binding pocket; inhibition site 1338518001197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518001198 catalytic residue [active] 1338518001199 succinic semialdehyde dehydrogenase; Region: PLN02278 1338518001200 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1338518001201 tetramerization interface [polypeptide binding]; other site 1338518001202 NAD(P) binding site [chemical binding]; other site 1338518001203 catalytic residues [active] 1338518001204 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1338518001205 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1338518001206 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1338518001207 NAD binding site [chemical binding]; other site 1338518001208 homodimer interface [polypeptide binding]; other site 1338518001209 active site 1338518001210 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1338518001211 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1338518001212 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1338518001213 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1338518001214 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1338518001215 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1338518001216 active site 1338518001217 P-loop; other site 1338518001218 phosphorylation site [posttranslational modification] 1338518001219 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1338518001220 active site 1338518001221 phosphorylation site [posttranslational modification] 1338518001222 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1338518001223 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1338518001224 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1338518001225 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1338518001226 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1338518001227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518001228 active site 1338518001229 motif I; other site 1338518001230 motif II; other site 1338518001231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518001232 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1338518001233 putative active site [active] 1338518001234 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1338518001235 hypothetical protein; Provisional; Region: PRK05463 1338518001236 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1338518001237 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1338518001238 active site 1338518001239 catalytic triad [active] 1338518001240 oxyanion hole [active] 1338518001241 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1338518001242 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1338518001243 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1338518001244 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1338518001245 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1338518001246 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1338518001247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1338518001248 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1338518001249 active site 1338518001250 catalytic tetrad [active] 1338518001251 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1338518001252 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1338518001253 acyl-activating enzyme (AAE) consensus motif; other site 1338518001254 putative AMP binding site [chemical binding]; other site 1338518001255 putative active site [active] 1338518001256 putative CoA binding site [chemical binding]; other site 1338518001257 short chain dehydrogenase; Provisional; Region: PRK06701 1338518001258 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1338518001259 NAD binding site [chemical binding]; other site 1338518001260 metal binding site [ion binding]; metal-binding site 1338518001261 active site 1338518001262 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1338518001263 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1338518001264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1338518001265 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1338518001266 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1338518001267 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1338518001268 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1338518001269 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1338518001270 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1338518001271 putative DNA binding site [nucleotide binding]; other site 1338518001272 putative Zn2+ binding site [ion binding]; other site 1338518001273 AsnC family; Region: AsnC_trans_reg; pfam01037 1338518001274 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1338518001275 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1338518001276 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1338518001277 NodB motif; other site 1338518001278 putative active site [active] 1338518001279 putative catalytic site [active] 1338518001280 putative Zn binding site [ion binding]; other site 1338518001281 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1338518001282 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1338518001283 DXD motif; other site 1338518001284 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1338518001285 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1338518001286 nudix motif; other site 1338518001287 pyruvate oxidase; Provisional; Region: PRK08611 1338518001288 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1338518001289 PYR/PP interface [polypeptide binding]; other site 1338518001290 dimer interface [polypeptide binding]; other site 1338518001291 tetramer interface [polypeptide binding]; other site 1338518001292 TPP binding site [chemical binding]; other site 1338518001293 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1338518001294 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1338518001295 TPP-binding site [chemical binding]; other site 1338518001296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518001297 Coenzyme A binding pocket [chemical binding]; other site 1338518001298 Evidence 4:Homologs of previously reported genes of unknown function 1338518001299 Evidence 4:Homologs of previously reported genes of unknown function 1338518001300 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1338518001301 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1338518001302 aspartate racemase; Region: asp_race; TIGR00035 1338518001303 Evidence 4:Homologs of previously reported genes of unknown function 1338518001304 Evidence 4:Homologs of previously reported genes of unknown function; Product type pf:putative factor 1338518001305 manganese transport protein MntH; Reviewed; Region: PRK00701 1338518001306 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1338518001307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1338518001308 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1338518001309 EcsC protein family; Region: EcsC; pfam12787 1338518001310 General stress protein [General function prediction only]; Region: GsiB; COG3729 1338518001311 General stress protein [General function prediction only]; Region: GsiB; COG3729 1338518001312 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1338518001313 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1338518001314 dimanganese center [ion binding]; other site 1338518001315 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1338518001316 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1338518001317 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1338518001318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518001319 putative active site [active] 1338518001320 heme pocket [chemical binding]; other site 1338518001321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518001322 ATP binding site [chemical binding]; other site 1338518001323 Mg2+ binding site [ion binding]; other site 1338518001324 G-X-G motif; other site 1338518001325 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1338518001326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518001327 active site 1338518001328 phosphorylation site [posttranslational modification] 1338518001329 intermolecular recognition site; other site 1338518001330 dimerization interface [polypeptide binding]; other site 1338518001331 HTH domain; Region: HTH_11; pfam08279 1338518001332 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1338518001333 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1338518001334 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1338518001335 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1338518001336 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1338518001337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518001338 Walker A/P-loop; other site 1338518001339 ATP binding site [chemical binding]; other site 1338518001340 Q-loop/lid; other site 1338518001341 ABC transporter signature motif; other site 1338518001342 Walker B; other site 1338518001343 D-loop; other site 1338518001344 H-loop/switch region; other site 1338518001345 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1338518001346 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1338518001347 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1338518001348 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1338518001349 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1338518001350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1338518001351 catalytic residues [active] 1338518001352 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1338518001353 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1338518001354 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1338518001355 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1338518001356 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1338518001357 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1338518001358 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1338518001359 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1338518001360 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1338518001361 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1338518001362 alanine racemase; Region: alr; TIGR00492 1338518001363 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1338518001364 active site 1338518001365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1338518001366 dimer interface [polypeptide binding]; other site 1338518001367 substrate binding site [chemical binding]; other site 1338518001368 catalytic residues [active] 1338518001369 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1338518001370 ribbon-helix-helix domain containing protein; Region: PHA00617 1338518001371 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1338518001372 Rsbr N terminal; Region: Rsbr_N; pfam08678 1338518001373 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1338518001374 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1338518001375 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1338518001376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518001377 ATP binding site [chemical binding]; other site 1338518001378 Mg2+ binding site [ion binding]; other site 1338518001379 G-X-G motif; other site 1338518001380 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1338518001381 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1338518001382 CoA binding domain; Region: CoA_binding; cl17356 1338518001383 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1338518001384 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1338518001385 anti sigma factor interaction site; other site 1338518001386 regulatory phosphorylation site [posttranslational modification]; other site 1338518001387 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1338518001388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518001389 ATP binding site [chemical binding]; other site 1338518001390 Mg2+ binding site [ion binding]; other site 1338518001391 G-X-G motif; other site 1338518001392 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1338518001393 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1338518001394 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1338518001395 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1338518001396 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1338518001397 RNA binding site [nucleotide binding]; other site 1338518001398 Evidence 4:Homologs of previously reported genes of unknown function; Product type lp:lipoprotein 1338518001399 TQO small subunit DoxD; Region: DoxD; pfam04173 1338518001400 Predicted transcriptional regulator [Transcription]; Region: COG1959 1338518001401 Transcriptional regulator; Region: Rrf2; pfam02082 1338518001402 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1338518001403 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1338518001404 proline/glycine betaine transporter; Provisional; Region: PRK10642 1338518001405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001406 putative substrate translocation pore; other site 1338518001407 MarR family; Region: MarR_2; cl17246 1338518001408 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1338518001409 putative active site [active] 1338518001410 putative catalytic site [active] 1338518001411 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1338518001412 Predicted transcriptional regulator [Transcription]; Region: COG1959 1338518001413 Transcriptional regulator; Region: Rrf2; pfam02082 1338518001414 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1338518001415 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1338518001416 NAD binding site [chemical binding]; other site 1338518001417 substrate binding site [chemical binding]; other site 1338518001418 putative active site [active] 1338518001419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518001420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518001421 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1338518001422 classical (c) SDRs; Region: SDR_c; cd05233 1338518001423 NAD(P) binding site [chemical binding]; other site 1338518001424 active site 1338518001425 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1338518001426 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1338518001427 putative NAD(P) binding site [chemical binding]; other site 1338518001428 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1338518001429 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1338518001430 putative di-iron ligands [ion binding]; other site 1338518001431 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1338518001432 DNA-binding site [nucleotide binding]; DNA binding site 1338518001433 RNA-binding motif; other site 1338518001434 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1338518001435 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1338518001436 aspartate racemase; Region: asp_race; TIGR00035 1338518001437 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1338518001438 Predicted transcriptional regulators [Transcription]; Region: COG1695 1338518001439 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1338518001440 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1338518001441 MarR family; Region: MarR; pfam01047 1338518001442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518001443 Coenzyme A binding pocket [chemical binding]; other site 1338518001444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518001446 putative substrate translocation pore; other site 1338518001447 Patatin [General function prediction only]; Region: COG3621 1338518001448 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1338518001449 active site 1338518001450 nucleophile elbow; other site 1338518001451 DinB family; Region: DinB; cl17821 1338518001452 DinB superfamily; Region: DinB_2; pfam12867 1338518001453 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1338518001454 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1338518001455 FAD binding domain; Region: FAD_binding_4; pfam01565 1338518001456 Berberine and berberine like; Region: BBE; pfam08031 1338518001457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518001458 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1338518001459 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1338518001460 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1338518001461 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1338518001462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1338518001463 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 1338518001464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518001465 FeS/SAM binding site; other site 1338518001466 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1338518001467 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1338518001468 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1338518001469 dimerization interface [polypeptide binding]; other site 1338518001470 active site 1338518001471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518001472 S-adenosylmethionine binding site [chemical binding]; other site 1338518001473 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1338518001474 dimer interface [polypeptide binding]; other site 1338518001475 substrate binding site [chemical binding]; other site 1338518001476 ATP binding site [chemical binding]; other site 1338518001477 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1338518001478 Sodium Bile acid symporter family; Region: SBF; cl17470 1338518001479 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1338518001480 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1338518001481 putative NAD(P) binding site [chemical binding]; other site 1338518001482 putative substrate binding site [chemical binding]; other site 1338518001483 catalytic Zn binding site [ion binding]; other site 1338518001484 structural Zn binding site [ion binding]; other site 1338518001485 dimer interface [polypeptide binding]; other site 1338518001486 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1338518001487 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1338518001488 DNA binding residues [nucleotide binding] 1338518001489 putative dimer interface [polypeptide binding]; other site 1338518001490 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1338518001491 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1338518001492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518001493 DNA-binding site [nucleotide binding]; DNA binding site 1338518001494 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518001495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518001496 homodimer interface [polypeptide binding]; other site 1338518001497 catalytic residue [active] 1338518001498 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1338518001499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518001501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518001502 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1338518001503 EamA-like transporter family; Region: EamA; cl17759 1338518001504 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1338518001505 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1338518001506 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1338518001507 NAD binding site [chemical binding]; other site 1338518001508 catalytic Zn binding site [ion binding]; other site 1338518001509 structural Zn binding site [ion binding]; other site 1338518001510 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1338518001511 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518001512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518001513 active site 1338518001514 phosphorylation site [posttranslational modification] 1338518001515 intermolecular recognition site; other site 1338518001516 dimerization interface [polypeptide binding]; other site 1338518001517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518001518 DNA binding residues [nucleotide binding] 1338518001519 dimerization interface [polypeptide binding]; other site 1338518001520 MMPL family; Region: MMPL; pfam03176 1338518001521 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1338518001522 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1338518001523 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518001524 ABC transporter; Region: ABC_tran_2; pfam12848 1338518001525 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518001526 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1338518001527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518001528 Coenzyme A binding pocket [chemical binding]; other site 1338518001529 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1338518001530 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518001531 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518001532 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1338518001533 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1338518001534 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1338518001535 dimer interface [polypeptide binding]; other site 1338518001536 active site 1338518001537 metal binding site [ion binding]; metal-binding site 1338518001538 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1338518001539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001540 putative substrate translocation pore; other site 1338518001541 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1338518001542 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1338518001543 dimer interface [polypeptide binding]; other site 1338518001544 active site 1338518001545 Helix-turn-helix domain; Region: HTH_31; pfam13560 1338518001546 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1338518001547 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1338518001548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518001549 Coenzyme A binding pocket [chemical binding]; other site 1338518001550 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1338518001551 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1338518001552 DNA binding residues [nucleotide binding] 1338518001553 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1338518001554 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1338518001555 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1338518001556 nudix motif; other site 1338518001557 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1338518001558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518001559 S-adenosylmethionine binding site [chemical binding]; other site 1338518001560 tartrate dehydrogenase; Provisional; Region: PRK08194 1338518001561 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1338518001562 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1338518001563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518001564 DNA-binding site [nucleotide binding]; DNA binding site 1338518001565 FCD domain; Region: FCD; pfam07729 1338518001566 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1338518001567 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1338518001568 active site 1338518001569 TDP-binding site; other site 1338518001570 acceptor substrate-binding pocket; other site 1338518001571 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1338518001572 Beta-lactamase; Region: Beta-lactamase; pfam00144 1338518001573 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1338518001574 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1338518001575 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1338518001576 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1338518001577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001578 putative substrate translocation pore; other site 1338518001579 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1338518001580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518001581 DNA-binding site [nucleotide binding]; DNA binding site 1338518001582 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1338518001583 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1338518001584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518001585 DNA-binding site [nucleotide binding]; DNA binding site 1338518001586 FCD domain; Region: FCD; pfam07729 1338518001587 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1338518001588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001589 putative substrate translocation pore; other site 1338518001590 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1338518001591 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1338518001592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518001593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518001594 amino acid transporter; Region: 2A0306; TIGR00909 1338518001595 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1338518001596 dimanganese center [ion binding]; other site 1338518001597 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1338518001598 putative hydrophobic ligand binding site [chemical binding]; other site 1338518001599 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1338518001600 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1338518001601 putative NADP binding site [chemical binding]; other site 1338518001602 putative dimer interface [polypeptide binding]; other site 1338518001603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001604 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1338518001605 putative substrate translocation pore; other site 1338518001606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001607 thiamine monophosphate kinase; Provisional; Region: PRK05731 1338518001608 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1338518001609 ATP binding site [chemical binding]; other site 1338518001610 dimerization interface [polypeptide binding]; other site 1338518001611 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1338518001612 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1338518001613 Glycoprotease family; Region: Peptidase_M22; pfam00814 1338518001614 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1338518001615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518001616 Coenzyme A binding pocket [chemical binding]; other site 1338518001617 UGMP family protein; Validated; Region: PRK09604 1338518001618 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1338518001619 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1338518001620 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1338518001621 trimer interface [polypeptide binding]; other site 1338518001622 dimer interface [polypeptide binding]; other site 1338518001623 putative active site [active] 1338518001624 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1338518001625 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1338518001626 CoA binding domain; Region: CoA_binding; pfam02629 1338518001627 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1338518001628 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1338518001629 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1338518001630 CAAX protease self-immunity; Region: Abi; pfam02517 1338518001631 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1338518001632 oligomerisation interface [polypeptide binding]; other site 1338518001633 mobile loop; other site 1338518001634 roof hairpin; other site 1338518001635 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1338518001636 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1338518001637 ring oligomerisation interface [polypeptide binding]; other site 1338518001638 ATP/Mg binding site [chemical binding]; other site 1338518001639 stacking interactions; other site 1338518001640 hinge regions; other site 1338518001641 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1338518001642 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1338518001643 active site 1338518001644 DNA binding site [nucleotide binding] 1338518001645 Int/Topo IB signature motif; other site 1338518001646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518001647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518001648 non-specific DNA binding site [nucleotide binding]; other site 1338518001649 salt bridge; other site 1338518001650 sequence-specific DNA binding site [nucleotide binding]; other site 1338518001651 BRO family, N-terminal domain; Region: Bro-N; cl10591 1338518001652 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1338518001653 Hypothetical protein Yqai; Region: Yqai; pfam09466 1338518001654 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1338518001655 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 1338518001656 Helix-turn-helix domain; Region: HTH_36; pfam13730 1338518001657 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1338518001658 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1338518001659 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1338518001660 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1338518001661 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1338518001662 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1338518001663 active site 1338518001664 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1338518001665 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1338518001666 inhibitor binding site; inhibition site 1338518001667 catalytic Zn binding site [ion binding]; other site 1338518001668 structural Zn binding site [ion binding]; other site 1338518001669 NADP binding site [chemical binding]; other site 1338518001670 tetramer interface [polypeptide binding]; other site 1338518001671 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1338518001672 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1338518001673 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1338518001674 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1338518001675 Repair protein; Region: Repair_PSII; pfam04536 1338518001676 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1338518001677 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1338518001678 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1338518001679 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1338518001680 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1338518001681 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1338518001682 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1338518001683 catalytic triad [active] 1338518001684 catalytic triad [active] 1338518001685 oxyanion hole [active] 1338518001686 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1338518001687 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1338518001688 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1338518001689 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518001690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518001691 DNA binding residues [nucleotide binding] 1338518001692 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1338518001693 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1338518001694 putative NAD(P) binding site [chemical binding]; other site 1338518001695 catalytic Zn binding site [ion binding]; other site 1338518001696 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1338518001697 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1338518001698 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1338518001699 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1338518001700 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1338518001701 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1338518001702 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1338518001703 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1338518001704 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1338518001705 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1338518001706 MoxR-like ATPases [General function prediction only]; Region: COG0714 1338518001707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518001708 Walker A motif; other site 1338518001709 ATP binding site [chemical binding]; other site 1338518001710 Walker B motif; other site 1338518001711 arginine finger; other site 1338518001712 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1338518001713 Protein of unknown function DUF58; Region: DUF58; pfam01882 1338518001714 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1338518001715 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1338518001716 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1338518001717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518001718 Coenzyme A binding pocket [chemical binding]; other site 1338518001719 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1338518001720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518001721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518001722 DNA binding residues [nucleotide binding] 1338518001723 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1338518001724 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1338518001725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1338518001726 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1338518001727 NETI protein; Region: NETI; pfam14044 1338518001728 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1338518001729 adenylosuccinate lyase; Provisional; Region: PRK07492 1338518001730 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1338518001731 tetramer interface [polypeptide binding]; other site 1338518001732 active site 1338518001733 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1338518001734 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1338518001735 ATP binding site [chemical binding]; other site 1338518001736 active site 1338518001737 substrate binding site [chemical binding]; other site 1338518001738 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1338518001739 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1338518001740 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1338518001741 putative active site [active] 1338518001742 catalytic triad [active] 1338518001743 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1338518001744 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1338518001745 dimerization interface [polypeptide binding]; other site 1338518001746 ATP binding site [chemical binding]; other site 1338518001747 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1338518001748 dimerization interface [polypeptide binding]; other site 1338518001749 ATP binding site [chemical binding]; other site 1338518001750 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1338518001751 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1338518001752 active site 1338518001753 tetramer interface [polypeptide binding]; other site 1338518001754 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1338518001755 active site 1338518001756 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1338518001757 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1338518001758 dimerization interface [polypeptide binding]; other site 1338518001759 putative ATP binding site [chemical binding]; other site 1338518001760 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1338518001761 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1338518001762 active site 1338518001763 substrate binding site [chemical binding]; other site 1338518001764 cosubstrate binding site; other site 1338518001765 catalytic site [active] 1338518001766 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1338518001767 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1338518001768 purine monophosphate binding site [chemical binding]; other site 1338518001769 dimer interface [polypeptide binding]; other site 1338518001770 putative catalytic residues [active] 1338518001771 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1338518001772 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1338518001773 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1338518001774 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1338518001775 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1338518001776 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1338518001777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1338518001778 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1338518001779 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1338518001780 active site 1338518001781 FMN binding site [chemical binding]; other site 1338518001782 substrate binding site [chemical binding]; other site 1338518001783 3Fe-4S cluster binding site [ion binding]; other site 1338518001784 PcrB family; Region: PcrB; pfam01884 1338518001785 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1338518001786 substrate binding site [chemical binding]; other site 1338518001787 putative active site [active] 1338518001788 dimer interface [polypeptide binding]; other site 1338518001789 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1338518001790 Part of AAA domain; Region: AAA_19; pfam13245 1338518001791 Family description; Region: UvrD_C_2; pfam13538 1338518001792 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1338518001793 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1338518001794 putative dimer interface [polypeptide binding]; other site 1338518001795 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1338518001796 putative dimer interface [polypeptide binding]; other site 1338518001797 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1338518001798 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1338518001799 active site 1338518001800 ATP binding site [chemical binding]; other site 1338518001801 substrate binding site [chemical binding]; other site 1338518001802 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1338518001803 MgtC family; Region: MgtC; pfam02308 1338518001804 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1338518001805 Na binding site [ion binding]; other site 1338518001806 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1338518001807 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1338518001808 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1338518001809 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1338518001810 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1338518001811 GatB domain; Region: GatB_Yqey; pfam02637 1338518001812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518001813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518001814 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1338518001815 Protein export membrane protein; Region: SecD_SecF; cl14618 1338518001816 putative lipid kinase; Reviewed; Region: PRK13337 1338518001817 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1338518001818 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1338518001819 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1338518001820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518001821 S-adenosylmethionine binding site [chemical binding]; other site 1338518001822 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1338518001823 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1338518001824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518001825 S-adenosylmethionine binding site [chemical binding]; other site 1338518001826 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1338518001827 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1338518001828 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1338518001829 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1338518001830 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1338518001831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518001832 ATP binding site [chemical binding]; other site 1338518001833 putative Mg++ binding site [ion binding]; other site 1338518001834 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1338518001835 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1338518001836 Protein of unknown function, DUF600; Region: DUF600; cl04640 1338518001837 Protein of unknown function, DUF600; Region: DUF600; cl04640 1338518001838 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1338518001839 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1338518001840 LXG domain of WXG superfamily; Region: LXG; pfam04740 1338518001841 hypothetical protein; Provisional; Region: PRK12378 1338518001842 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1338518001843 CotJB protein; Region: CotJB; pfam12652 1338518001844 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1338518001845 dimanganese center [ion binding]; other site 1338518001846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518001847 Coenzyme A binding pocket [chemical binding]; other site 1338518001848 YesK-like protein; Region: YesK; pfam14150 1338518001849 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1338518001850 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1338518001851 Uncharacterized small protein [Function unknown]; Region: COG5583 1338518001852 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1338518001853 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1338518001854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518001855 MarR family; Region: MarR; pfam01047 1338518001856 hypothetical protein; Provisional; Region: PRK06847 1338518001857 hypothetical protein; Provisional; Region: PRK07236 1338518001858 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1338518001859 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1338518001860 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1338518001861 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1338518001862 Sulfatase; Region: Sulfatase; pfam00884 1338518001863 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1338518001864 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1338518001865 substrate binding site; other site 1338518001866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1338518001867 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1338518001868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1338518001869 active site 1338518001870 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1338518001871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518001873 putative substrate translocation pore; other site 1338518001874 amino acid transporter; Region: 2A0306; TIGR00909 1338518001875 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1338518001876 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1338518001877 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1338518001878 NAD(P) binding site [chemical binding]; other site 1338518001879 catalytic residues [active] 1338518001880 oxidoreductase; Provisional; Region: PRK07985 1338518001881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518001882 NAD(P) binding site [chemical binding]; other site 1338518001883 active site 1338518001884 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1338518001885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518001886 Walker A/P-loop; other site 1338518001887 ATP binding site [chemical binding]; other site 1338518001888 Q-loop/lid; other site 1338518001889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518001890 ABC transporter signature motif; other site 1338518001891 Walker B; other site 1338518001892 D-loop; other site 1338518001893 ABC transporter; Region: ABC_tran_2; pfam12848 1338518001894 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518001895 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1338518001896 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1338518001897 DNA binding residues [nucleotide binding] 1338518001898 putative dimer interface [polypeptide binding]; other site 1338518001899 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1338518001900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518001901 putative substrate translocation pore; other site 1338518001902 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1338518001903 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518001904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518001905 ABC transporter; Region: ABC_tran_2; pfam12848 1338518001906 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518001907 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1338518001908 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1338518001909 ATP binding site [chemical binding]; other site 1338518001910 Mg++ binding site [ion binding]; other site 1338518001911 motif III; other site 1338518001912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518001913 nucleotide binding region [chemical binding]; other site 1338518001914 ATP-binding site [chemical binding]; other site 1338518001915 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1338518001916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518001917 Coenzyme A binding pocket [chemical binding]; other site 1338518001918 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1338518001919 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1338518001920 NAD(P) binding site [chemical binding]; other site 1338518001921 substrate binding site [chemical binding]; other site 1338518001922 dimer interface [polypeptide binding]; other site 1338518001923 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1338518001924 Heat induced stress protein YflT; Region: YflT; pfam11181 1338518001925 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1338518001926 Amb_all domain; Region: Amb_all; smart00656 1338518001927 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1338518001928 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1338518001929 transmembrane helices; other site 1338518001930 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1338518001931 Evidence 4:Homologs of previously reported genes of unknown function 1338518001932 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1338518001933 PAS domain; Region: PAS; smart00091 1338518001934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518001935 ATP binding site [chemical binding]; other site 1338518001936 Mg2+ binding site [ion binding]; other site 1338518001937 G-X-G motif; other site 1338518001938 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1338518001939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518001940 active site 1338518001941 phosphorylation site [posttranslational modification] 1338518001942 intermolecular recognition site; other site 1338518001943 dimerization interface [polypeptide binding]; other site 1338518001944 Transcriptional regulator; Region: CitT; pfam12431 1338518001945 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1338518001946 Citrate transporter; Region: CitMHS; pfam03600 1338518001947 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1338518001948 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1338518001949 active site 1338518001950 dimer interface [polypeptide binding]; other site 1338518001951 acylphosphatase; Provisional; Region: PRK14420 1338518001952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1338518001953 MOSC domain; Region: MOSC; pfam03473 1338518001954 3-alpha domain; Region: 3-alpha; pfam03475 1338518001955 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1338518001956 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1338518001957 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1338518001958 active site 1338518001959 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1338518001960 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1338518001961 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1338518001962 active site turn [active] 1338518001963 phosphorylation site [posttranslational modification] 1338518001964 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1338518001965 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1338518001966 Sulfatase; Region: Sulfatase; pfam00884 1338518001967 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1338518001968 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1338518001969 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1338518001970 putative dimer interface [polypeptide binding]; other site 1338518001971 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1338518001972 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1338518001973 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1338518001974 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1338518001975 active site turn [active] 1338518001976 phosphorylation site [posttranslational modification] 1338518001977 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1338518001978 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1338518001979 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1338518001980 Ca binding site [ion binding]; other site 1338518001981 active site 1338518001982 catalytic site [active] 1338518001983 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1338518001984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518001985 DNA-binding site [nucleotide binding]; DNA binding site 1338518001986 UTRA domain; Region: UTRA; pfam07702 1338518001987 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1338518001988 dimer interface [polypeptide binding]; other site 1338518001989 FMN binding site [chemical binding]; other site 1338518001990 YibE/F-like protein; Region: YibE_F; pfam07907 1338518001991 YibE/F-like protein; Region: YibE_F; pfam07907 1338518001992 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1338518001993 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1338518001994 proposed catalytic triad [active] 1338518001995 conserved cys residue [active] 1338518001996 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518001997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518001998 DNA binding site [nucleotide binding] 1338518001999 domain linker motif; other site 1338518002000 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1338518002001 putative dimerization interface [polypeptide binding]; other site 1338518002002 putative ligand binding site [chemical binding]; other site 1338518002003 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1338518002004 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1338518002005 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1338518002006 shikimate binding site; other site 1338518002007 NAD(P) binding site [chemical binding]; other site 1338518002008 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1338518002009 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1338518002010 active site 1338518002011 catalytic residue [active] 1338518002012 dimer interface [polypeptide binding]; other site 1338518002013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518002015 putative substrate translocation pore; other site 1338518002016 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1338518002017 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1338518002018 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1338518002019 active site 1338518002020 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1338518002021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002022 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518002023 putative substrate translocation pore; other site 1338518002024 calcium/proton exchanger (cax); Region: cax; TIGR00378 1338518002025 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1338518002026 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1338518002027 YfkD-like protein; Region: YfkD; pfam14167 1338518002028 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1338518002029 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1338518002030 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1338518002031 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518002032 FeS/SAM binding site; other site 1338518002033 YfkB-like domain; Region: YfkB; pfam08756 1338518002034 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1338518002035 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1338518002036 NodB motif; other site 1338518002037 active site 1338518002038 catalytic site [active] 1338518002039 Cd binding site [ion binding]; other site 1338518002040 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1338518002041 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1338518002042 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1338518002043 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1338518002044 oligomer interface [polypeptide binding]; other site 1338518002045 metal binding site [ion binding]; metal-binding site 1338518002046 metal binding site [ion binding]; metal-binding site 1338518002047 putative Cl binding site [ion binding]; other site 1338518002048 aspartate ring; other site 1338518002049 basic sphincter; other site 1338518002050 hydrophobic gate; other site 1338518002051 periplasmic entrance; other site 1338518002052 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1338518002053 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1338518002054 minor groove reading motif; other site 1338518002055 helix-hairpin-helix signature motif; other site 1338518002056 substrate binding pocket [chemical binding]; other site 1338518002057 active site 1338518002058 TRAM domain; Region: TRAM; pfam01938 1338518002059 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1338518002060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518002061 S-adenosylmethionine binding site [chemical binding]; other site 1338518002062 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1338518002063 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1338518002064 FMN binding site [chemical binding]; other site 1338518002065 active site 1338518002066 catalytic residues [active] 1338518002067 substrate binding site [chemical binding]; other site 1338518002068 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1338518002069 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1338518002070 tetramer interface [polypeptide binding]; other site 1338518002071 TPP-binding site [chemical binding]; other site 1338518002072 heterodimer interface [polypeptide binding]; other site 1338518002073 phosphorylation loop region [posttranslational modification] 1338518002074 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1338518002075 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1338518002076 alpha subunit interface [polypeptide binding]; other site 1338518002077 TPP binding site [chemical binding]; other site 1338518002078 heterodimer interface [polypeptide binding]; other site 1338518002079 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1338518002080 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1338518002081 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1338518002082 E3 interaction surface; other site 1338518002083 lipoyl attachment site [posttranslational modification]; other site 1338518002084 e3 binding domain; Region: E3_binding; pfam02817 1338518002085 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1338518002086 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1338518002087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518002088 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1338518002089 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1338518002090 GAF domain; Region: GAF; pfam01590 1338518002091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518002092 Walker A motif; other site 1338518002093 ATP binding site [chemical binding]; other site 1338518002094 Walker B motif; other site 1338518002095 arginine finger; other site 1338518002096 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1338518002097 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1338518002098 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1338518002099 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1338518002100 NAD binding site [chemical binding]; other site 1338518002101 sugar binding site [chemical binding]; other site 1338518002102 divalent metal binding site [ion binding]; other site 1338518002103 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1338518002104 dimer interface [polypeptide binding]; other site 1338518002105 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1338518002106 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1338518002107 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1338518002108 putative active site [active] 1338518002109 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1338518002110 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1338518002111 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1338518002112 active site turn [active] 1338518002113 phosphorylation site [posttranslational modification] 1338518002114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1338518002115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1338518002116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518002117 Walker A/P-loop; other site 1338518002118 ATP binding site [chemical binding]; other site 1338518002119 Q-loop/lid; other site 1338518002120 ABC transporter signature motif; other site 1338518002121 Walker B; other site 1338518002122 D-loop; other site 1338518002123 H-loop/switch region; other site 1338518002124 Predicted membrane protein [Function unknown]; Region: COG2259 1338518002125 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1338518002126 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1338518002127 putative metal binding site [ion binding]; other site 1338518002128 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1338518002129 active site 1338518002130 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1338518002131 UbiA prenyltransferase family; Region: UbiA; pfam01040 1338518002132 Predicted transcriptional regulators [Transcription]; Region: COG1695 1338518002133 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1338518002134 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1338518002135 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1338518002136 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1338518002137 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1338518002138 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1338518002139 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1338518002140 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1338518002141 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1338518002142 RNAase interaction site [polypeptide binding]; other site 1338518002143 metal-dependent hydrolase; Provisional; Region: PRK13291 1338518002144 DinB superfamily; Region: DinB_2; pfam12867 1338518002145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518002147 putative substrate translocation pore; other site 1338518002148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002149 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518002150 MarR family; Region: MarR; pfam01047 1338518002151 Predicted integral membrane protein [Function unknown]; Region: COG0392 1338518002152 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1338518002153 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1338518002154 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1338518002155 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1338518002156 putative FMN binding site [chemical binding]; other site 1338518002157 YfhD-like protein; Region: YfhD; pfam14151 1338518002158 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1338518002159 TIGR01777 family protein; Region: yfcH 1338518002160 putative NAD(P) binding site [chemical binding]; other site 1338518002161 putative active site [active] 1338518002162 recombination regulator RecX; Provisional; Region: recX; PRK14135 1338518002163 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1338518002164 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1338518002165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002166 putative substrate translocation pore; other site 1338518002167 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1338518002168 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1338518002169 WVELL protein; Region: WVELL; pfam14043 1338518002170 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1338518002171 Bacterial SH3 domain; Region: SH3_3; cl17532 1338518002172 SdpI/YhfL protein family; Region: SdpI; pfam13630 1338518002173 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1338518002174 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1338518002175 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1338518002176 Ligand binding site; other site 1338518002177 Putative Catalytic site; other site 1338518002178 DXD motif; other site 1338518002179 Predicted membrane protein [Function unknown]; Region: COG4485 1338518002180 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1338518002181 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1338518002182 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1338518002183 minor groove reading motif; other site 1338518002184 helix-hairpin-helix signature motif; other site 1338518002185 substrate binding pocket [chemical binding]; other site 1338518002186 active site 1338518002187 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1338518002188 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1338518002189 DNA binding and oxoG recognition site [nucleotide binding] 1338518002190 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1338518002191 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1338518002192 putative NAD(P) binding site [chemical binding]; other site 1338518002193 active site 1338518002194 YgaB-like protein; Region: YgaB; pfam14182 1338518002195 hypothetical protein; Provisional; Region: PRK13662 1338518002196 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1338518002197 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1338518002198 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1338518002199 Walker A/P-loop; other site 1338518002200 ATP binding site [chemical binding]; other site 1338518002201 Q-loop/lid; other site 1338518002202 ABC transporter signature motif; other site 1338518002203 Walker B; other site 1338518002204 D-loop; other site 1338518002205 H-loop/switch region; other site 1338518002206 Predicted membrane protein [Function unknown]; Region: COG4129 1338518002207 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1338518002208 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1338518002209 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518002210 inhibitor-cofactor binding pocket; inhibition site 1338518002211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518002212 catalytic residue [active] 1338518002213 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1338518002214 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1338518002215 catalytic triad [active] 1338518002216 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1338518002217 metal binding site 2 [ion binding]; metal-binding site 1338518002218 putative DNA binding helix; other site 1338518002219 metal binding site 1 [ion binding]; metal-binding site 1338518002220 dimer interface [polypeptide binding]; other site 1338518002221 structural Zn2+ binding site [ion binding]; other site 1338518002222 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1338518002223 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1338518002224 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1338518002225 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1338518002226 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1338518002227 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1338518002228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518002229 dimer interface [polypeptide binding]; other site 1338518002230 conserved gate region; other site 1338518002231 putative PBP binding loops; other site 1338518002232 ABC-ATPase subunit interface; other site 1338518002233 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1338518002234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1338518002235 Walker A/P-loop; other site 1338518002236 ATP binding site [chemical binding]; other site 1338518002237 Q-loop/lid; other site 1338518002238 ABC transporter signature motif; other site 1338518002239 Walker B; other site 1338518002240 D-loop; other site 1338518002241 H-loop/switch region; other site 1338518002242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1338518002243 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1338518002244 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1338518002245 tetramer interface [polypeptide binding]; other site 1338518002246 heme binding pocket [chemical binding]; other site 1338518002247 NADPH binding site [chemical binding]; other site 1338518002248 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1338518002249 active site 1338518002250 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1338518002251 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1338518002252 Walker A/P-loop; other site 1338518002253 ATP binding site [chemical binding]; other site 1338518002254 Q-loop/lid; other site 1338518002255 ABC transporter signature motif; other site 1338518002256 Walker B; other site 1338518002257 D-loop; other site 1338518002258 H-loop/switch region; other site 1338518002259 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1338518002260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1338518002261 substrate binding pocket [chemical binding]; other site 1338518002262 membrane-bound complex binding site; other site 1338518002263 hinge residues; other site 1338518002264 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1338518002265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518002266 dimer interface [polypeptide binding]; other site 1338518002267 conserved gate region; other site 1338518002268 putative PBP binding loops; other site 1338518002269 ABC-ATPase subunit interface; other site 1338518002270 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1338518002271 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1338518002272 active site 1338518002273 dimer interface [polypeptide binding]; other site 1338518002274 non-prolyl cis peptide bond; other site 1338518002275 insertion regions; other site 1338518002276 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1338518002277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518002278 non-specific DNA binding site [nucleotide binding]; other site 1338518002279 salt bridge; other site 1338518002280 sequence-specific DNA binding site [nucleotide binding]; other site 1338518002281 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1338518002282 Putative amidase domain; Region: Amidase_6; pfam12671 1338518002283 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1338518002284 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1338518002285 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1338518002286 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1338518002287 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1338518002288 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1338518002289 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518002290 MarR family; Region: MarR; pfam01047 1338518002291 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1338518002292 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1338518002293 carboxyltransferase (CT) interaction site; other site 1338518002294 biotinylation site [posttranslational modification]; other site 1338518002295 HlyD family secretion protein; Region: HlyD_3; pfam13437 1338518002296 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1338518002297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002298 putative substrate translocation pore; other site 1338518002299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002300 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1338518002301 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1338518002302 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1338518002303 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1338518002304 Walker A/P-loop; other site 1338518002305 ATP binding site [chemical binding]; other site 1338518002306 Q-loop/lid; other site 1338518002307 ABC transporter signature motif; other site 1338518002308 Walker B; other site 1338518002309 D-loop; other site 1338518002310 H-loop/switch region; other site 1338518002311 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1338518002312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518002313 Walker A/P-loop; other site 1338518002314 ATP binding site [chemical binding]; other site 1338518002315 Q-loop/lid; other site 1338518002316 ABC transporter signature motif; other site 1338518002317 Walker B; other site 1338518002318 D-loop; other site 1338518002319 H-loop/switch region; other site 1338518002320 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1338518002321 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1338518002322 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1338518002323 DNA-binding site [nucleotide binding]; DNA binding site 1338518002324 RNA-binding motif; other site 1338518002325 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1338518002326 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1338518002327 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1338518002328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1338518002329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1338518002330 metal binding site [ion binding]; metal-binding site 1338518002331 active site 1338518002332 I-site; other site 1338518002333 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1338518002334 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1338518002335 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1338518002336 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1338518002337 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1338518002338 active site 1338518002339 catalytic site [active] 1338518002340 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1338518002341 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1338518002342 active site 1338518002343 FOG: CBS domain [General function prediction only]; Region: COG0517 1338518002344 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1338518002345 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1338518002346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518002347 motif II; other site 1338518002348 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1338518002349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518002350 Coenzyme A binding pocket [chemical binding]; other site 1338518002351 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1338518002352 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1338518002353 putative active site [active] 1338518002354 catalytic triad [active] 1338518002355 putative dimer interface [polypeptide binding]; other site 1338518002356 aminotransferase; Validated; Region: PRK07678 1338518002357 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518002358 inhibitor-cofactor binding pocket; inhibition site 1338518002359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518002360 catalytic residue [active] 1338518002361 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1338518002362 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1338518002363 amphipathic channel; other site 1338518002364 Asn-Pro-Ala signature motifs; other site 1338518002365 glycerol kinase; Provisional; Region: glpK; PRK00047 1338518002366 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1338518002367 N- and C-terminal domain interface [polypeptide binding]; other site 1338518002368 active site 1338518002369 MgATP binding site [chemical binding]; other site 1338518002370 catalytic site [active] 1338518002371 metal binding site [ion binding]; metal-binding site 1338518002372 glycerol binding site [chemical binding]; other site 1338518002373 homotetramer interface [polypeptide binding]; other site 1338518002374 homodimer interface [polypeptide binding]; other site 1338518002375 FBP binding site [chemical binding]; other site 1338518002376 protein IIAGlc interface [polypeptide binding]; other site 1338518002377 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1338518002378 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1338518002379 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1338518002380 active site 1338518002381 substrate binding site [chemical binding]; other site 1338518002382 metal binding site [ion binding]; metal-binding site 1338518002383 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1338518002384 GAF domain; Region: GAF; pfam01590 1338518002385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1338518002386 Histidine kinase; Region: HisKA_3; pfam07730 1338518002387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518002388 ATP binding site [chemical binding]; other site 1338518002389 Mg2+ binding site [ion binding]; other site 1338518002390 G-X-G motif; other site 1338518002391 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518002392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518002393 active site 1338518002394 phosphorylation site [posttranslational modification] 1338518002395 intermolecular recognition site; other site 1338518002396 dimerization interface [polypeptide binding]; other site 1338518002397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518002398 DNA binding residues [nucleotide binding] 1338518002399 dimerization interface [polypeptide binding]; other site 1338518002400 Predicted flavoprotein [General function prediction only]; Region: COG0431 1338518002401 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1338518002402 YhdB-like protein; Region: YhdB; pfam14148 1338518002403 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1338518002404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518002405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518002406 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1338518002407 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518002408 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518002409 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518002410 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1338518002411 NlpC/P60 family; Region: NLPC_P60; pfam00877 1338518002412 Transcriptional regulator; Region: Rrf2; cl17282 1338518002413 Rrf2 family protein; Region: rrf2_super; TIGR00738 1338518002414 Conserved TM helix; Region: TM_helix; pfam05552 1338518002415 Conserved TM helix; Region: TM_helix; pfam05552 1338518002416 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1338518002417 SpoVR like protein; Region: SpoVR; pfam04293 1338518002418 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1338518002419 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1338518002420 dimer interface [polypeptide binding]; other site 1338518002421 active site 1338518002422 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518002423 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518002424 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1338518002425 NlpC/P60 family; Region: NLPC_P60; pfam00877 1338518002426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518002427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518002428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518002429 dimerization interface [polypeptide binding]; other site 1338518002430 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1338518002431 dimer interface [polypeptide binding]; other site 1338518002432 Citrate synthase; Region: Citrate_synt; pfam00285 1338518002433 active site 1338518002434 citrylCoA binding site [chemical binding]; other site 1338518002435 oxalacetate/citrate binding site [chemical binding]; other site 1338518002436 coenzyme A binding site [chemical binding]; other site 1338518002437 catalytic triad [active] 1338518002438 short chain dehydrogenase; Provisional; Region: PRK06701 1338518002439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518002440 NAD(P) binding site [chemical binding]; other site 1338518002441 active site 1338518002442 amino acid transporter; Region: 2A0306; TIGR00909 1338518002443 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1338518002444 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1338518002445 Na2 binding site [ion binding]; other site 1338518002446 putative substrate binding site 1 [chemical binding]; other site 1338518002447 Na binding site 1 [ion binding]; other site 1338518002448 putative substrate binding site 2 [chemical binding]; other site 1338518002449 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1338518002450 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1338518002451 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1338518002452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518002453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518002454 DNA binding residues [nucleotide binding] 1338518002455 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1338518002456 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1338518002457 putative acyl-acceptor binding pocket; other site 1338518002458 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1338518002459 Domain of unknown function DUF21; Region: DUF21; pfam01595 1338518002460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1338518002461 Transporter associated domain; Region: CorC_HlyC; smart01091 1338518002462 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1338518002463 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1338518002464 DNA binding residues [nucleotide binding] 1338518002465 putative dimer interface [polypeptide binding]; other site 1338518002466 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1338518002467 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1338518002468 dimer interface [polypeptide binding]; other site 1338518002469 active site 1338518002470 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1338518002471 Domain of unknown function DUF21; Region: DUF21; pfam01595 1338518002472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1338518002473 Transporter associated domain; Region: CorC_HlyC; smart01091 1338518002474 camphor resistance protein CrcB; Provisional; Region: PRK14213 1338518002475 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1338518002476 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1338518002477 active site 1338518002478 catalytic site [active] 1338518002479 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1338518002480 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1338518002481 NAD-dependent deacetylase; Provisional; Region: PRK00481 1338518002482 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1338518002483 NAD+ binding site [chemical binding]; other site 1338518002484 substrate binding site [chemical binding]; other site 1338518002485 Zn binding site [ion binding]; other site 1338518002486 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1338518002487 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1338518002488 NodB motif; other site 1338518002489 active site 1338518002490 catalytic site [active] 1338518002491 Zn binding site [ion binding]; other site 1338518002492 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1338518002493 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1338518002494 homodimer interface [polypeptide binding]; other site 1338518002495 substrate-cofactor binding pocket; other site 1338518002496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518002497 catalytic residue [active] 1338518002498 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1338518002499 Ligand Binding Site [chemical binding]; other site 1338518002500 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1338518002501 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1338518002502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518002503 Walker A/P-loop; other site 1338518002504 ATP binding site [chemical binding]; other site 1338518002505 Q-loop/lid; other site 1338518002506 ABC transporter signature motif; other site 1338518002507 Walker B; other site 1338518002508 D-loop; other site 1338518002509 H-loop/switch region; other site 1338518002510 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1338518002511 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1338518002512 NAD binding site [chemical binding]; other site 1338518002513 substrate binding site [chemical binding]; other site 1338518002514 putative active site [active] 1338518002515 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1338518002516 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1338518002517 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1338518002518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1338518002519 hypothetical protein; Provisional; Region: PRK13676 1338518002520 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1338518002521 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1338518002522 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1338518002523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518002524 active site 1338518002525 motif I; other site 1338518002526 motif II; other site 1338518002527 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1338518002528 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1338518002529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518002530 FeS/SAM binding site; other site 1338518002531 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1338518002532 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1338518002533 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1338518002534 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1338518002535 TrkA-C domain; Region: TrkA_C; pfam02080 1338518002536 enoyl-CoA hydratase; Provisional; Region: PRK07659 1338518002537 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1338518002538 substrate binding site [chemical binding]; other site 1338518002539 oxyanion hole (OAH) forming residues; other site 1338518002540 trimer interface [polypeptide binding]; other site 1338518002541 YhzD-like protein; Region: YhzD; pfam14120 1338518002542 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1338518002543 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1338518002544 Walker A/P-loop; other site 1338518002545 ATP binding site [chemical binding]; other site 1338518002546 Q-loop/lid; other site 1338518002547 ABC transporter signature motif; other site 1338518002548 Walker B; other site 1338518002549 D-loop; other site 1338518002550 H-loop/switch region; other site 1338518002551 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1338518002552 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1338518002553 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1338518002554 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1338518002555 active site 1338518002556 metal binding site [ion binding]; metal-binding site 1338518002557 DNA binding site [nucleotide binding] 1338518002558 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1338518002559 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1338518002560 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1338518002561 generic binding surface II; other site 1338518002562 generic binding surface I; other site 1338518002563 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518002564 Zn2+ binding site [ion binding]; other site 1338518002565 Mg2+ binding site [ion binding]; other site 1338518002566 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1338518002567 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1338518002568 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1338518002569 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1338518002570 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1338518002571 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1338518002572 transcriptional regulator Hpr; Provisional; Region: PRK13777 1338518002573 MarR family; Region: MarR; pfam01047 1338518002574 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1338518002575 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1338518002576 homodimer interface [polypeptide binding]; other site 1338518002577 substrate-cofactor binding pocket; other site 1338518002578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518002579 catalytic residue [active] 1338518002580 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1338518002581 HIT family signature motif; other site 1338518002582 catalytic residue [active] 1338518002583 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1338518002584 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1338518002585 Walker A/P-loop; other site 1338518002586 ATP binding site [chemical binding]; other site 1338518002587 Q-loop/lid; other site 1338518002588 ABC transporter signature motif; other site 1338518002589 Walker B; other site 1338518002590 D-loop; other site 1338518002591 H-loop/switch region; other site 1338518002592 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1338518002593 EcsC protein family; Region: EcsC; pfam12787 1338518002594 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1338518002595 Transglycosylase; Region: Transgly; pfam00912 1338518002596 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1338518002597 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1338518002598 ferrochelatase; Provisional; Region: PRK12435 1338518002599 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1338518002600 C-terminal domain interface [polypeptide binding]; other site 1338518002601 active site 1338518002602 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1338518002603 active site 1338518002604 N-terminal domain interface [polypeptide binding]; other site 1338518002605 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1338518002606 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1338518002607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518002608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518002609 Predicted membrane protein [Function unknown]; Region: COG1511 1338518002610 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1338518002611 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1338518002612 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1338518002613 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1338518002614 dimer interface [polypeptide binding]; other site 1338518002615 active site 1338518002616 CoA binding pocket [chemical binding]; other site 1338518002617 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1338518002618 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1338518002619 putative oligomer interface [polypeptide binding]; other site 1338518002620 putative active site [active] 1338518002621 metal binding site [ion binding]; metal-binding site 1338518002622 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1338518002623 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1338518002624 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1338518002625 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1338518002626 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1338518002627 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1338518002628 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1338518002629 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1338518002630 NAD(P) binding site [chemical binding]; other site 1338518002631 putative active site [active] 1338518002632 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1338518002633 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1338518002634 acyl-activating enzyme (AAE) consensus motif; other site 1338518002635 putative AMP binding site [chemical binding]; other site 1338518002636 putative active site [active] 1338518002637 putative CoA binding site [chemical binding]; other site 1338518002638 Peptidase family M48; Region: Peptidase_M48; pfam01435 1338518002639 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1338518002640 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1338518002641 active site 1338518002642 catalytic residues [active] 1338518002643 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1338518002644 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1338518002645 siderophore binding site; other site 1338518002646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1338518002647 catalytic core [active] 1338518002648 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1338518002649 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1338518002650 dimer interface [polypeptide binding]; other site 1338518002651 active site 1338518002652 acyl-CoA synthetase; Validated; Region: PRK07638 1338518002653 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1338518002654 acyl-activating enzyme (AAE) consensus motif; other site 1338518002655 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1338518002656 acyl-activating enzyme (AAE) consensus motif; other site 1338518002657 AMP binding site [chemical binding]; other site 1338518002658 active site 1338518002659 CoA binding site [chemical binding]; other site 1338518002660 BioY family; Region: BioY; pfam02632 1338518002661 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1338518002662 heme-binding site [chemical binding]; other site 1338518002663 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1338518002664 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518002665 dimer interface [polypeptide binding]; other site 1338518002666 putative CheW interface [polypeptide binding]; other site 1338518002667 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1338518002668 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1338518002669 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1338518002670 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1338518002671 [2Fe-2S] cluster binding site [ion binding]; other site 1338518002672 short chain dehydrogenase; Provisional; Region: PRK06701 1338518002673 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1338518002674 NAD binding site [chemical binding]; other site 1338518002675 metal binding site [ion binding]; metal-binding site 1338518002676 active site 1338518002677 A short protein domain of unknown function; Region: IDEAL; smart00914 1338518002678 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1338518002679 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1338518002680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1338518002681 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1338518002682 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1338518002683 putative binding site; other site 1338518002684 putative dimer interface [polypeptide binding]; other site 1338518002685 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1338518002686 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1338518002687 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1338518002688 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1338518002689 Na binding site [ion binding]; other site 1338518002690 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1338518002691 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1338518002692 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1338518002693 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1338518002694 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1338518002695 Catalytic site [active] 1338518002696 hypothetical protein; Provisional; Region: PRK08244 1338518002697 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1338518002698 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518002699 MarR family; Region: MarR; pfam01047 1338518002700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002701 putative substrate translocation pore; other site 1338518002702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518002703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518002704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518002705 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1338518002706 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1338518002707 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1338518002708 dinuclear metal binding motif [ion binding]; other site 1338518002709 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1338518002710 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1338518002711 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1338518002712 Part of AAA domain; Region: AAA_19; pfam13245 1338518002713 Family description; Region: UvrD_C_2; pfam13538 1338518002714 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1338518002715 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1338518002716 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1338518002717 active site 1338518002718 metal binding site [ion binding]; metal-binding site 1338518002719 DNA binding site [nucleotide binding] 1338518002720 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1338518002721 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1338518002722 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1338518002723 Walker A/P-loop; other site 1338518002724 ATP binding site [chemical binding]; other site 1338518002725 Q-loop/lid; other site 1338518002726 ABC transporter signature motif; other site 1338518002727 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1338518002728 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1338518002729 ABC transporter signature motif; other site 1338518002730 Walker B; other site 1338518002731 D-loop; other site 1338518002732 H-loop/switch region; other site 1338518002733 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1338518002734 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1338518002735 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1338518002736 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1338518002737 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1338518002738 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1338518002739 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1338518002740 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1338518002741 hypothetical protein; Provisional; Region: PRK13673 1338518002742 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1338518002743 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1338518002744 active site 1338518002745 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1338518002746 dimer interface [polypeptide binding]; other site 1338518002747 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1338518002748 Ligand Binding Site [chemical binding]; other site 1338518002749 Molecular Tunnel; other site 1338518002750 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1338518002751 substrate binding pocket [chemical binding]; other site 1338518002752 substrate-Mg2+ binding site; other site 1338518002753 aspartate-rich region 1; other site 1338518002754 aspartate-rich region 2; other site 1338518002755 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1338518002756 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1338518002757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518002758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518002759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1338518002760 DinB superfamily; Region: DinB_2; pfam12867 1338518002761 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1338518002762 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1338518002763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1338518002764 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1338518002765 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1338518002766 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1338518002767 FAD binding site [chemical binding]; other site 1338518002768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1338518002769 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1338518002770 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1338518002771 S1 domain; Region: S1_2; pfam13509 1338518002772 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1338518002773 RNA binding site [nucleotide binding]; other site 1338518002774 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1338518002775 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1338518002776 ligand binding site [chemical binding]; other site 1338518002777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518002778 dimerization interface [polypeptide binding]; other site 1338518002779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1338518002780 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518002781 dimer interface [polypeptide binding]; other site 1338518002782 putative CheW interface [polypeptide binding]; other site 1338518002783 EDD domain protein, DegV family; Region: DegV; TIGR00762 1338518002784 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1338518002785 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1338518002786 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518002787 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518002788 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1338518002789 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1338518002790 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1338518002791 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1338518002792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518002793 motif II; other site 1338518002794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518002795 esterase; Provisional; Region: PRK10566 1338518002796 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1338518002797 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1338518002798 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1338518002799 active site 1338518002800 metal binding site [ion binding]; metal-binding site 1338518002801 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1338518002802 FAD binding domain; Region: FAD_binding_4; pfam01565 1338518002803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518002804 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518002805 putative substrate translocation pore; other site 1338518002806 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1338518002807 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1338518002808 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1338518002809 heterotetramer interface [polypeptide binding]; other site 1338518002810 active site pocket [active] 1338518002811 cleavage site 1338518002812 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1338518002813 nucleotide binding site [chemical binding]; other site 1338518002814 N-acetyl-L-glutamate binding site [chemical binding]; other site 1338518002815 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1338518002816 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518002817 inhibitor-cofactor binding pocket; inhibition site 1338518002818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518002819 catalytic residue [active] 1338518002820 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1338518002821 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1338518002822 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1338518002823 catalytic site [active] 1338518002824 subunit interface [polypeptide binding]; other site 1338518002825 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1338518002826 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1338518002827 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1338518002828 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1338518002829 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1338518002830 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1338518002831 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1338518002832 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1338518002833 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1338518002834 YjzC-like protein; Region: YjzC; pfam14168 1338518002835 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1338518002836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518002837 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1338518002838 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1338518002839 putative ligand binding site [chemical binding]; other site 1338518002840 ComZ; Region: ComZ; pfam10815 1338518002841 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1338518002842 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1338518002843 dimer interface [polypeptide binding]; other site 1338518002844 active site 1338518002845 CoA binding pocket [chemical binding]; other site 1338518002846 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1338518002847 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1338518002848 dimer interface [polypeptide binding]; other site 1338518002849 active site 1338518002850 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1338518002851 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1338518002852 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1338518002853 Walker A/P-loop; other site 1338518002854 ATP binding site [chemical binding]; other site 1338518002855 Q-loop/lid; other site 1338518002856 ABC transporter signature motif; other site 1338518002857 Walker B; other site 1338518002858 D-loop; other site 1338518002859 H-loop/switch region; other site 1338518002860 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1338518002861 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1338518002862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1338518002863 Walker A/P-loop; other site 1338518002864 ATP binding site [chemical binding]; other site 1338518002865 Q-loop/lid; other site 1338518002866 ABC transporter signature motif; other site 1338518002867 Walker B; other site 1338518002868 D-loop; other site 1338518002869 H-loop/switch region; other site 1338518002870 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1338518002871 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1338518002872 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1338518002873 peptide binding site [polypeptide binding]; other site 1338518002874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1338518002875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518002876 dimer interface [polypeptide binding]; other site 1338518002877 conserved gate region; other site 1338518002878 putative PBP binding loops; other site 1338518002879 ABC-ATPase subunit interface; other site 1338518002880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1338518002881 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1338518002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518002883 dimer interface [polypeptide binding]; other site 1338518002884 conserved gate region; other site 1338518002885 putative PBP binding loops; other site 1338518002886 ABC-ATPase subunit interface; other site 1338518002887 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1338518002888 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1338518002889 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1338518002890 active site 1338518002891 HIGH motif; other site 1338518002892 dimer interface [polypeptide binding]; other site 1338518002893 KMSKS motif; other site 1338518002894 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1338518002895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518002896 dimer interface [polypeptide binding]; other site 1338518002897 conserved gate region; other site 1338518002898 putative PBP binding loops; other site 1338518002899 ABC-ATPase subunit interface; other site 1338518002900 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1338518002901 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1338518002902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518002903 dimer interface [polypeptide binding]; other site 1338518002904 conserved gate region; other site 1338518002905 putative PBP binding loops; other site 1338518002906 ABC-ATPase subunit interface; other site 1338518002907 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1338518002908 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1338518002909 Walker A/P-loop; other site 1338518002910 ATP binding site [chemical binding]; other site 1338518002911 Q-loop/lid; other site 1338518002912 ABC transporter signature motif; other site 1338518002913 Walker B; other site 1338518002914 D-loop; other site 1338518002915 H-loop/switch region; other site 1338518002916 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1338518002917 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1338518002918 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1338518002919 Walker A/P-loop; other site 1338518002920 ATP binding site [chemical binding]; other site 1338518002921 Q-loop/lid; other site 1338518002922 ABC transporter signature motif; other site 1338518002923 Walker B; other site 1338518002924 D-loop; other site 1338518002925 H-loop/switch region; other site 1338518002926 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1338518002927 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1338518002928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1338518002929 Coenzyme A binding pocket [chemical binding]; other site 1338518002930 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1338518002931 ArsC family; Region: ArsC; pfam03960 1338518002932 putative catalytic residues [active] 1338518002933 thiol/disulfide switch; other site 1338518002934 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1338518002935 adaptor protein; Provisional; Region: PRK02315 1338518002936 Competence protein CoiA-like family; Region: CoiA; cl11541 1338518002937 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1338518002938 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1338518002939 catalytic residues [active] 1338518002940 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1338518002941 apolar tunnel; other site 1338518002942 heme binding site [chemical binding]; other site 1338518002943 dimerization interface [polypeptide binding]; other site 1338518002944 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1338518002945 putative active site [active] 1338518002946 putative metal binding residues [ion binding]; other site 1338518002947 signature motif; other site 1338518002948 putative triphosphate binding site [ion binding]; other site 1338518002949 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1338518002950 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1338518002951 synthetase active site [active] 1338518002952 NTP binding site [chemical binding]; other site 1338518002953 metal binding site [ion binding]; metal-binding site 1338518002954 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1338518002955 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1338518002956 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1338518002957 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1338518002958 active site 1338518002959 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1338518002960 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1338518002961 active site 1338518002962 metal binding site [ion binding]; metal-binding site 1338518002963 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1338518002964 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1338518002965 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1338518002966 TrkA-N domain; Region: TrkA_N; pfam02254 1338518002967 TrkA-C domain; Region: TrkA_C; pfam02080 1338518002968 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1338518002969 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1338518002970 thiamine phosphate binding site [chemical binding]; other site 1338518002971 active site 1338518002972 pyrophosphate binding site [ion binding]; other site 1338518002973 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1338518002974 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1338518002975 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1338518002976 thiS-thiF/thiG interaction site; other site 1338518002977 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1338518002978 ThiS interaction site; other site 1338518002979 putative active site [active] 1338518002980 tetramer interface [polypeptide binding]; other site 1338518002981 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1338518002982 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1338518002983 ATP binding site [chemical binding]; other site 1338518002984 substrate interface [chemical binding]; other site 1338518002985 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1338518002986 dimer interface [polypeptide binding]; other site 1338518002987 substrate binding site [chemical binding]; other site 1338518002988 ATP binding site [chemical binding]; other site 1338518002989 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1338518002990 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1338518002991 NAD binding site [chemical binding]; other site 1338518002992 homotetramer interface [polypeptide binding]; other site 1338518002993 homodimer interface [polypeptide binding]; other site 1338518002994 substrate binding site [chemical binding]; other site 1338518002995 active site 1338518002996 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1338518002997 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1338518002998 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1338518002999 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1338518003000 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1338518003001 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1338518003002 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1338518003003 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1338518003004 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1338518003005 Part of AAA domain; Region: AAA_19; pfam13245 1338518003006 Family description; Region: UvrD_C_2; pfam13538 1338518003007 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1338518003008 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1338518003009 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1338518003010 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1338518003011 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1338518003012 Walker A/P-loop; other site 1338518003013 ATP binding site [chemical binding]; other site 1338518003014 Q-loop/lid; other site 1338518003015 ABC transporter signature motif; other site 1338518003016 Walker B; other site 1338518003017 D-loop; other site 1338518003018 H-loop/switch region; other site 1338518003019 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1338518003020 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1338518003021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1338518003022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518003023 Coenzyme A binding pocket [chemical binding]; other site 1338518003024 hypothetical protein; Provisional; Region: PRK13679 1338518003025 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1338518003026 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1338518003027 Putative esterase; Region: Esterase; pfam00756 1338518003028 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1338518003029 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1338518003030 homodimer interface [polypeptide binding]; other site 1338518003031 substrate-cofactor binding pocket; other site 1338518003032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518003033 catalytic residue [active] 1338518003034 cystathionine beta-lyase; Provisional; Region: PRK08064 1338518003035 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1338518003036 homodimer interface [polypeptide binding]; other site 1338518003037 substrate-cofactor binding pocket; other site 1338518003038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518003039 catalytic residue [active] 1338518003040 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518003041 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1338518003042 active site 1338518003043 metal binding site [ion binding]; metal-binding site 1338518003044 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1338518003045 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1338518003046 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1338518003047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518003048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518003049 putative substrate translocation pore; other site 1338518003050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518003051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518003052 putative Zn2+ binding site [ion binding]; other site 1338518003053 putative DNA binding site [nucleotide binding]; other site 1338518003054 dimerization interface [polypeptide binding]; other site 1338518003055 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1338518003056 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1338518003057 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1338518003058 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1338518003059 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1338518003060 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1338518003061 NAD binding site [chemical binding]; other site 1338518003062 homodimer interface [polypeptide binding]; other site 1338518003063 active site 1338518003064 substrate binding site [chemical binding]; other site 1338518003065 galactokinase; Provisional; Region: PRK05322 1338518003066 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1338518003067 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1338518003068 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1338518003069 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1338518003070 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1338518003071 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1338518003072 active site 1338518003073 P-loop; other site 1338518003074 phosphorylation site [posttranslational modification] 1338518003075 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1338518003076 methionine cluster; other site 1338518003077 active site 1338518003078 phosphorylation site [posttranslational modification] 1338518003079 metal binding site [ion binding]; metal-binding site 1338518003080 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1338518003081 beta-galactosidase; Region: BGL; TIGR03356 1338518003082 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1338518003083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518003084 motif II; other site 1338518003085 hypothetical protein; Provisional; Region: PRK09272 1338518003086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518003087 MarR family; Region: MarR; pfam01047 1338518003088 MgtC family; Region: MgtC; pfam02308 1338518003089 Putative motility protein; Region: YjfB_motility; pfam14070 1338518003090 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1338518003091 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1338518003092 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1338518003093 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1338518003094 Cytochrome P450; Region: p450; cl12078 1338518003095 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1338518003096 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1338518003097 active site 1338518003098 TIGR00245 family protein; Region: TIGR00245 1338518003099 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1338518003100 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1338518003101 Walker A/P-loop; other site 1338518003102 ATP binding site [chemical binding]; other site 1338518003103 Q-loop/lid; other site 1338518003104 ABC transporter signature motif; other site 1338518003105 Walker B; other site 1338518003106 D-loop; other site 1338518003107 H-loop/switch region; other site 1338518003108 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1338518003109 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1338518003110 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1338518003111 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1338518003112 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518003113 Glucuronate isomerase; Region: UxaC; pfam02614 1338518003114 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1338518003115 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1338518003116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518003117 putative substrate translocation pore; other site 1338518003118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518003119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518003120 DNA binding site [nucleotide binding] 1338518003121 domain linker motif; other site 1338518003122 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1338518003123 dimerization interface [polypeptide binding]; other site 1338518003124 ligand binding site [chemical binding]; other site 1338518003125 altronate oxidoreductase; Provisional; Region: PRK03643 1338518003126 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1338518003127 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1338518003128 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1338518003129 DinB family; Region: DinB; cl17821 1338518003130 DinB superfamily; Region: DinB_2; pfam12867 1338518003131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518003132 binding surface 1338518003133 TPR motif; other site 1338518003134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518003135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1338518003136 binding surface 1338518003137 TPR motif; other site 1338518003138 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1338518003139 pentamer interface [polypeptide binding]; other site 1338518003140 dodecaamer interface [polypeptide binding]; other site 1338518003141 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1338518003142 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1338518003143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518003144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518003145 non-specific DNA binding site [nucleotide binding]; other site 1338518003146 salt bridge; other site 1338518003147 sequence-specific DNA binding site [nucleotide binding]; other site 1338518003148 hypothetical protein; Provisional; Region: PRK06921 1338518003149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518003150 Walker A motif; other site 1338518003151 ATP binding site [chemical binding]; other site 1338518003152 Walker B motif; other site 1338518003153 positive control sigma-like factor; Validated; Region: PRK06930 1338518003154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518003155 DNA binding residues [nucleotide binding] 1338518003156 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1338518003157 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1338518003158 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1338518003159 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1338518003160 Phage capsid family; Region: Phage_capsid; pfam05065 1338518003161 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1338518003162 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1338518003163 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1338518003164 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1338518003165 Phage XkdN-like protein; Region: XkdN; pfam08890 1338518003166 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1338518003167 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518003168 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1338518003169 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1338518003170 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1338518003171 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1338518003172 XkdW protein; Region: XkdW; pfam09636 1338518003173 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1338518003174 Haemolysin XhlA; Region: XhlA; pfam10779 1338518003175 Phage lysis protein, holin; Region: Phage_holin; pfam04688 1338518003176 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1338518003177 amidase catalytic site [active] 1338518003178 Zn binding residues [ion binding]; other site 1338518003179 substrate binding site [chemical binding]; other site 1338518003180 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518003181 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1338518003182 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1338518003183 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1338518003184 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1338518003185 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1338518003186 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1338518003187 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1338518003188 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518003189 Zn binding site [ion binding]; other site 1338518003190 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1338518003191 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518003192 Zn binding site [ion binding]; other site 1338518003193 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1338518003194 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1338518003195 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1338518003196 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1338518003197 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1338518003198 Ligand binding site; other site 1338518003199 Putative Catalytic site; other site 1338518003200 DXD motif; other site 1338518003201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518003202 putative substrate translocation pore; other site 1338518003203 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518003204 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1338518003205 SxDxEG motif; other site 1338518003206 active site 1338518003207 metal binding site [ion binding]; metal-binding site 1338518003208 homopentamer interface [polypeptide binding]; other site 1338518003209 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1338518003210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518003211 dimer interface [polypeptide binding]; other site 1338518003212 conserved gate region; other site 1338518003213 putative PBP binding loops; other site 1338518003214 ABC-ATPase subunit interface; other site 1338518003215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1338518003216 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1338518003217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518003218 dimer interface [polypeptide binding]; other site 1338518003219 conserved gate region; other site 1338518003220 putative PBP binding loops; other site 1338518003221 ABC-ATPase subunit interface; other site 1338518003222 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1338518003223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1338518003224 Walker A/P-loop; other site 1338518003225 ATP binding site [chemical binding]; other site 1338518003226 Q-loop/lid; other site 1338518003227 ABC transporter signature motif; other site 1338518003228 Walker B; other site 1338518003229 D-loop; other site 1338518003230 H-loop/switch region; other site 1338518003231 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1338518003232 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1338518003233 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1338518003234 peptide binding site [polypeptide binding]; other site 1338518003235 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1338518003236 dimer interface [polypeptide binding]; other site 1338518003237 catalytic triad [active] 1338518003238 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1338518003239 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1338518003240 active site 1338518003241 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1338518003242 NlpC/P60 family; Region: NLPC_P60; pfam00877 1338518003243 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1338518003244 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1338518003245 Walker A/P-loop; other site 1338518003246 ATP binding site [chemical binding]; other site 1338518003247 Q-loop/lid; other site 1338518003248 ABC transporter signature motif; other site 1338518003249 Walker B; other site 1338518003250 D-loop; other site 1338518003251 H-loop/switch region; other site 1338518003252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1338518003253 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1338518003254 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1338518003255 Amidinotransferase; Region: Amidinotransf; pfam02274 1338518003256 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1338518003257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1338518003258 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1338518003259 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1338518003260 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1338518003261 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1338518003262 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1338518003263 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1338518003264 putative active site [active] 1338518003265 putative substrate binding site [chemical binding]; other site 1338518003266 putative cosubstrate binding site; other site 1338518003267 catalytic site [active] 1338518003268 gamma-glutamyl kinase; Provisional; Region: PRK05429 1338518003269 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1338518003270 nucleotide binding site [chemical binding]; other site 1338518003271 homotetrameric interface [polypeptide binding]; other site 1338518003272 putative phosphate binding site [ion binding]; other site 1338518003273 putative allosteric binding site; other site 1338518003274 PUA domain; Region: PUA; pfam01472 1338518003275 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1338518003276 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1338518003277 putative catalytic cysteine [active] 1338518003278 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1338518003279 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1338518003280 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1338518003281 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1338518003282 putative metal binding site; other site 1338518003283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518003284 binding surface 1338518003285 TPR motif; other site 1338518003286 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1338518003287 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1338518003288 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1338518003289 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1338518003290 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1338518003291 THF binding site; other site 1338518003292 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1338518003293 substrate binding site [chemical binding]; other site 1338518003294 THF binding site; other site 1338518003295 zinc-binding site [ion binding]; other site 1338518003296 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1338518003297 active site 1338518003298 catalytic residues [active] 1338518003299 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1338518003300 Cobalt transport protein; Region: CbiQ; pfam02361 1338518003301 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1338518003302 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1338518003303 Walker A/P-loop; other site 1338518003304 ATP binding site [chemical binding]; other site 1338518003305 Q-loop/lid; other site 1338518003306 ABC transporter signature motif; other site 1338518003307 Walker B; other site 1338518003308 D-loop; other site 1338518003309 H-loop/switch region; other site 1338518003310 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1338518003311 Walker A/P-loop; other site 1338518003312 ATP binding site [chemical binding]; other site 1338518003313 Q-loop/lid; other site 1338518003314 ABC transporter signature motif; other site 1338518003315 Walker B; other site 1338518003316 D-loop; other site 1338518003317 H-loop/switch region; other site 1338518003318 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1338518003319 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1338518003320 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518003321 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518003322 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1338518003323 active site 1338518003324 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1338518003325 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1338518003326 MgtE intracellular N domain; Region: MgtE_N; smart00924 1338518003327 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1338518003328 Divalent cation transporter; Region: MgtE; pfam01769 1338518003329 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1338518003330 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1338518003331 DNA binding residues [nucleotide binding] 1338518003332 putative dimer interface [polypeptide binding]; other site 1338518003333 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518003334 MarR family; Region: MarR; pfam01047 1338518003335 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1338518003336 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1338518003337 putative DNA binding site [nucleotide binding]; other site 1338518003338 putative homodimer interface [polypeptide binding]; other site 1338518003339 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1338518003340 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1338518003341 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1338518003342 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1338518003343 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518003344 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1338518003345 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1338518003346 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1338518003347 heat shock protein HtpX; Provisional; Region: PRK05457 1338518003348 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1338518003349 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1338518003350 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1338518003351 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1338518003352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518003353 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1338518003354 putative active site [active] 1338518003355 heme pocket [chemical binding]; other site 1338518003356 PAS domain; Region: PAS; smart00091 1338518003357 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1338518003358 PAS domain; Region: PAS; smart00091 1338518003359 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1338518003360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518003361 dimer interface [polypeptide binding]; other site 1338518003362 phosphorylation site [posttranslational modification] 1338518003363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518003364 ATP binding site [chemical binding]; other site 1338518003365 Mg2+ binding site [ion binding]; other site 1338518003366 G-X-G motif; other site 1338518003367 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1338518003368 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1338518003369 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1338518003370 DNA binding site [nucleotide binding] 1338518003371 active site 1338518003372 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1338518003373 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1338518003374 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1338518003375 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1338518003376 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1338518003377 putative active site [active] 1338518003378 catalytic triad [active] 1338518003379 putative dimer interface [polypeptide binding]; other site 1338518003380 transaminase; Reviewed; Region: PRK08068 1338518003381 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518003382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518003383 homodimer interface [polypeptide binding]; other site 1338518003384 catalytic residue [active] 1338518003385 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1338518003386 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1338518003387 dimer interface [polypeptide binding]; other site 1338518003388 active site 1338518003389 catalytic residue [active] 1338518003390 metal binding site [ion binding]; metal-binding site 1338518003391 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1338518003392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518003393 motif II; other site 1338518003394 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1338518003395 intersubunit interface [polypeptide binding]; other site 1338518003396 active site 1338518003397 Zn2+ binding site [ion binding]; other site 1338518003398 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1338518003399 Cupin domain; Region: Cupin_2; pfam07883 1338518003400 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1338518003401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518003402 dimer interface [polypeptide binding]; other site 1338518003403 phosphorylation site [posttranslational modification] 1338518003404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518003405 ATP binding site [chemical binding]; other site 1338518003406 Mg2+ binding site [ion binding]; other site 1338518003407 G-X-G motif; other site 1338518003408 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518003409 MarR family; Region: MarR; pfam01047 1338518003410 flagellar motor protein MotA; Validated; Region: PRK08124 1338518003411 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1338518003412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518003413 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1338518003414 Walker A motif; other site 1338518003415 ATP binding site [chemical binding]; other site 1338518003416 Walker B motif; other site 1338518003417 arginine finger; other site 1338518003418 UvrB/uvrC motif; Region: UVR; pfam02151 1338518003419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518003420 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1338518003421 Walker A motif; other site 1338518003422 ATP binding site [chemical binding]; other site 1338518003423 Walker B motif; other site 1338518003424 arginine finger; other site 1338518003425 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1338518003426 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1338518003427 Ligand Binding Site [chemical binding]; other site 1338518003428 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1338518003429 active site 1338518003430 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1338518003431 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1338518003432 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1338518003433 Predicted transcriptional regulators [Transcription]; Region: COG1733 1338518003434 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1338518003435 short chain dehydrogenase; Provisional; Region: PRK06500 1338518003436 classical (c) SDRs; Region: SDR_c; cd05233 1338518003437 NAD(P) binding site [chemical binding]; other site 1338518003438 active site 1338518003439 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:9384377, 14660578, 15767583; Product type e:enzyme 1338518003440 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1338518003441 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518003442 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1338518003443 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1338518003444 active site 1338518003445 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1338518003446 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1338518003447 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1338518003448 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1338518003449 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1338518003450 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1338518003451 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1338518003452 catalytic residues [active] 1338518003453 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1338518003454 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1338518003455 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1338518003456 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1338518003457 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1338518003458 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1338518003459 active site 1338518003460 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518003461 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518003462 DNA binding site [nucleotide binding] 1338518003463 domain linker motif; other site 1338518003464 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1338518003465 putative dimerization interface [polypeptide binding]; other site 1338518003466 putative ligand binding site [chemical binding]; other site 1338518003467 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1338518003468 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1338518003469 PRD domain; Region: PRD; pfam00874 1338518003470 PRD domain; Region: PRD; pfam00874 1338518003471 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1338518003472 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1338518003473 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1338518003474 active site turn [active] 1338518003475 phosphorylation site [posttranslational modification] 1338518003476 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1338518003477 HPr interaction site; other site 1338518003478 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1338518003479 active site 1338518003480 phosphorylation site [posttranslational modification] 1338518003481 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1338518003482 dimerization domain swap beta strand [polypeptide binding]; other site 1338518003483 regulatory protein interface [polypeptide binding]; other site 1338518003484 active site 1338518003485 regulatory phosphorylation site [posttranslational modification]; other site 1338518003486 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1338518003487 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1338518003488 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1338518003489 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1338518003490 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1338518003491 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1338518003492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518003493 FeS/SAM binding site; other site 1338518003494 Cache domain; Region: Cache_1; pfam02743 1338518003495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518003496 dimerization interface [polypeptide binding]; other site 1338518003497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518003498 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1338518003499 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518003500 dimer interface [polypeptide binding]; other site 1338518003501 putative CheW interface [polypeptide binding]; other site 1338518003502 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1338518003503 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1338518003504 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1338518003505 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1338518003506 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1338518003507 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1338518003508 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1338518003509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1338518003510 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1338518003511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518003512 putative active site [active] 1338518003513 heme pocket [chemical binding]; other site 1338518003514 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1338518003515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518003516 putative active site [active] 1338518003517 heme pocket [chemical binding]; other site 1338518003518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518003519 putative active site [active] 1338518003520 heme pocket [chemical binding]; other site 1338518003521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518003522 dimer interface [polypeptide binding]; other site 1338518003523 phosphorylation site [posttranslational modification] 1338518003524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518003525 ATP binding site [chemical binding]; other site 1338518003526 Mg2+ binding site [ion binding]; other site 1338518003527 G-X-G motif; other site 1338518003528 aminotransferase A; Validated; Region: PRK07683 1338518003529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518003530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518003531 homodimer interface [polypeptide binding]; other site 1338518003532 catalytic residue [active] 1338518003533 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1338518003534 putative CheA interaction surface; other site 1338518003535 Response regulator receiver domain; Region: Response_reg; pfam00072 1338518003536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518003537 active site 1338518003538 phosphorylation site [posttranslational modification] 1338518003539 intermolecular recognition site; other site 1338518003540 dimerization interface [polypeptide binding]; other site 1338518003541 YkyB-like protein; Region: YkyB; pfam14177 1338518003542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518003543 H+ Antiporter protein; Region: 2A0121; TIGR00900 1338518003544 putative substrate translocation pore; other site 1338518003545 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518003546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1338518003547 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1338518003548 phosphodiesterase YaeI; Provisional; Region: PRK11340 1338518003549 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1338518003550 putative active site [active] 1338518003551 putative metal binding site [ion binding]; other site 1338518003552 short chain dehydrogenase; Provisional; Region: PRK07677 1338518003553 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1338518003554 NAD(P) binding site [chemical binding]; other site 1338518003555 substrate binding site [chemical binding]; other site 1338518003556 homotetramer interface [polypeptide binding]; other site 1338518003557 active site 1338518003558 homodimer interface [polypeptide binding]; other site 1338518003559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1338518003560 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1338518003561 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1338518003562 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1338518003563 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1338518003564 FOG: CBS domain [General function prediction only]; Region: COG0517 1338518003565 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1338518003566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518003567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518003568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518003569 dimerization interface [polypeptide binding]; other site 1338518003570 flavodoxin; Provisional; Region: PRK06703 1338518003571 BNR repeat-like domain; Region: BNR_2; pfam13088 1338518003572 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1338518003573 flavodoxin, short chain; Region: flav_short; TIGR01753 1338518003574 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1338518003575 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1338518003576 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1338518003577 active site 1338518003578 trimer interface [polypeptide binding]; other site 1338518003579 substrate binding site [chemical binding]; other site 1338518003580 CoA binding site [chemical binding]; other site 1338518003581 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1338518003582 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1338518003583 metal binding site [ion binding]; metal-binding site 1338518003584 hypothetical protein; Provisional; Region: PRK03094 1338518003585 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1338518003586 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1338518003587 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1338518003588 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1338518003589 catalytic residues [active] 1338518003590 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1338518003591 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1338518003592 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1338518003593 GTP binding site; other site 1338518003594 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1338518003595 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1338518003596 ATP binding site [chemical binding]; other site 1338518003597 substrate interface [chemical binding]; other site 1338518003598 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1338518003599 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1338518003600 dimer interface [polypeptide binding]; other site 1338518003601 putative functional site; other site 1338518003602 putative MPT binding site; other site 1338518003603 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1338518003604 Walker A motif; other site 1338518003605 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1338518003606 MoaE homodimer interface [polypeptide binding]; other site 1338518003607 MoaD interaction [polypeptide binding]; other site 1338518003608 active site residues [active] 1338518003609 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1338518003610 MoaE interaction surface [polypeptide binding]; other site 1338518003611 MoeB interaction surface [polypeptide binding]; other site 1338518003612 thiocarboxylated glycine; other site 1338518003613 Yip1 domain; Region: Yip1; pfam04893 1338518003614 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1338518003615 HlyD family secretion protein; Region: HlyD_3; pfam13437 1338518003616 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1338518003617 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1338518003618 Walker A/P-loop; other site 1338518003619 ATP binding site [chemical binding]; other site 1338518003620 Q-loop/lid; other site 1338518003621 ABC transporter signature motif; other site 1338518003622 Walker B; other site 1338518003623 D-loop; other site 1338518003624 H-loop/switch region; other site 1338518003625 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1338518003626 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1338518003627 FtsX-like permease family; Region: FtsX; pfam02687 1338518003628 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1338518003629 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1338518003630 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1338518003631 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1338518003632 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1338518003633 putative substrate binding site [chemical binding]; other site 1338518003634 putative ATP binding site [chemical binding]; other site 1338518003635 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1338518003636 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1338518003637 active site 1338518003638 phosphorylation site [posttranslational modification] 1338518003639 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1338518003640 active site 1338518003641 P-loop; other site 1338518003642 phosphorylation site [posttranslational modification] 1338518003643 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1338518003644 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1338518003645 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1338518003646 Catalytic site [active] 1338518003647 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1338518003648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518003649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518003650 ABC transporter; Region: ABC_tran_2; pfam12848 1338518003651 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1338518003652 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1338518003653 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1338518003654 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1338518003655 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1338518003656 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1338518003657 rod-share determining protein MreBH; Provisional; Region: PRK13929 1338518003658 MreB and similar proteins; Region: MreB_like; cd10225 1338518003659 nucleotide binding site [chemical binding]; other site 1338518003660 Mg binding site [ion binding]; other site 1338518003661 putative protofilament interaction site [polypeptide binding]; other site 1338518003662 RodZ interaction site [polypeptide binding]; other site 1338518003663 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1338518003664 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1338518003665 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1338518003666 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1338518003667 putative active site pocket [active] 1338518003668 dimerization interface [polypeptide binding]; other site 1338518003669 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1338518003670 putative active site pocket [active] 1338518003671 dimerization interface [polypeptide binding]; other site 1338518003672 putative catalytic residue [active] 1338518003673 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1338518003674 TrkA-N domain; Region: TrkA_N; pfam02254 1338518003675 TrkA-C domain; Region: TrkA_C; pfam02080 1338518003676 adenine deaminase; Region: ade; TIGR01178 1338518003677 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1338518003678 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1338518003679 active site 1338518003680 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1338518003681 hypothetical protein; Provisional; Region: PRK13667 1338518003682 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1338518003683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518003684 active site 1338518003685 motif I; other site 1338518003686 motif II; other site 1338518003687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518003688 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1338518003689 active site 1338518003690 catalytic residues [active] 1338518003691 metal binding site [ion binding]; metal-binding site 1338518003692 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1338518003693 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1338518003694 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1338518003695 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1338518003696 FMN binding site [chemical binding]; other site 1338518003697 substrate binding site [chemical binding]; other site 1338518003698 putative catalytic residue [active] 1338518003699 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003700 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518003701 active site 1338518003702 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003703 KR domain; Region: KR; pfam08659 1338518003704 putative NADP binding site [chemical binding]; other site 1338518003705 active site 1338518003706 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518003707 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003708 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518003709 active site 1338518003710 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518003711 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003712 putative NADP binding site [chemical binding]; other site 1338518003713 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518003714 active site 1338518003715 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518003716 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518003717 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1338518003718 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003719 active site 1338518003720 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518003721 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003722 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518003723 putative NADP binding site [chemical binding]; other site 1338518003724 active site 1338518003725 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518003726 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003727 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518003728 active site 1338518003729 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518003730 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003731 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518003732 putative NADP binding site [chemical binding]; other site 1338518003733 active site 1338518003734 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518003735 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003736 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518003737 active site 1338518003738 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518003739 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003740 putative NADP binding site [chemical binding]; other site 1338518003741 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518003742 active site 1338518003743 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518003744 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003745 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1338518003746 active site 1338518003747 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518003748 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003749 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518003750 putative NADP binding site [chemical binding]; other site 1338518003751 active site 1338518003752 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518003753 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003754 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518003755 active site 1338518003756 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003757 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518003758 putative NADP binding site [chemical binding]; other site 1338518003759 active site 1338518003760 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518003761 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518003762 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003763 active site 1338518003764 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518003765 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518003766 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003767 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518003768 putative NADP binding site [chemical binding]; other site 1338518003769 active site 1338518003770 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518003771 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518003772 active site 1338518003773 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518003774 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518003775 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518003776 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518003777 putative NADP binding site [chemical binding]; other site 1338518003778 KR domain; Region: KR; pfam08659 1338518003779 active site 1338518003780 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1338518003781 Beta-lactamase; Region: Beta-lactamase; pfam00144 1338518003782 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1338518003783 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1338518003784 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1338518003785 TPP-binding site [chemical binding]; other site 1338518003786 tetramer interface [polypeptide binding]; other site 1338518003787 heterodimer interface [polypeptide binding]; other site 1338518003788 phosphorylation loop region [posttranslational modification] 1338518003789 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1338518003790 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1338518003791 alpha subunit interface [polypeptide binding]; other site 1338518003792 TPP binding site [chemical binding]; other site 1338518003793 heterodimer interface [polypeptide binding]; other site 1338518003794 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1338518003795 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1338518003796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1338518003797 E3 interaction surface; other site 1338518003798 lipoyl attachment site [posttranslational modification]; other site 1338518003799 e3 binding domain; Region: E3_binding; pfam02817 1338518003800 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1338518003801 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1338518003802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1338518003803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518003804 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1338518003805 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1338518003806 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1338518003807 NodB motif; other site 1338518003808 active site 1338518003809 catalytic site [active] 1338518003810 metal binding site [ion binding]; metal-binding site 1338518003811 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1338518003812 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1338518003813 homodimer interface [polypeptide binding]; other site 1338518003814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518003815 catalytic residue [active] 1338518003816 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1338518003817 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1338518003818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1338518003819 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1338518003820 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1338518003821 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1338518003822 active site 1338518003823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518003824 Coenzyme A binding pocket [chemical binding]; other site 1338518003825 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1338518003826 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1338518003827 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1338518003828 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1338518003829 active site 1338518003830 Zn binding site [ion binding]; other site 1338518003831 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1338518003832 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1338518003833 G1 box; other site 1338518003834 putative GEF interaction site [polypeptide binding]; other site 1338518003835 GTP/Mg2+ binding site [chemical binding]; other site 1338518003836 Switch I region; other site 1338518003837 G2 box; other site 1338518003838 G3 box; other site 1338518003839 Switch II region; other site 1338518003840 G4 box; other site 1338518003841 G5 box; other site 1338518003842 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1338518003843 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1338518003844 YlaH-like protein; Region: YlaH; pfam14036 1338518003845 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1338518003846 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1338518003847 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1338518003848 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1338518003849 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1338518003850 putative active site [active] 1338518003851 PhoH-like protein; Region: PhoH; pfam02562 1338518003852 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1338518003853 glutaminase A; Region: Gln_ase; TIGR03814 1338518003854 hypothetical protein; Provisional; Region: PRK13666 1338518003855 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1338518003856 pyruvate carboxylase; Reviewed; Region: PRK12999 1338518003857 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1338518003858 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1338518003859 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1338518003860 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1338518003861 active site 1338518003862 catalytic residues [active] 1338518003863 metal binding site [ion binding]; metal-binding site 1338518003864 homodimer binding site [polypeptide binding]; other site 1338518003865 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1338518003866 carboxyltransferase (CT) interaction site; other site 1338518003867 biotinylation site [posttranslational modification]; other site 1338518003868 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1338518003869 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1338518003870 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1338518003871 UbiA prenyltransferase family; Region: UbiA; pfam01040 1338518003872 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1338518003873 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1338518003874 Cytochrome c; Region: Cytochrom_C; pfam00034 1338518003875 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1338518003876 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1338518003877 D-pathway; other site 1338518003878 Putative ubiquinol binding site [chemical binding]; other site 1338518003879 Low-spin heme (heme b) binding site [chemical binding]; other site 1338518003880 Putative water exit pathway; other site 1338518003881 Binuclear center (heme o3/CuB) [ion binding]; other site 1338518003882 K-pathway; other site 1338518003883 Putative proton exit pathway; other site 1338518003884 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1338518003885 Subunit I/III interface [polypeptide binding]; other site 1338518003886 Subunit III/IV interface [polypeptide binding]; other site 1338518003887 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1338518003888 YugN-like family; Region: YugN; pfam08868 1338518003889 FOG: CBS domain [General function prediction only]; Region: COG0517 1338518003890 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1338518003891 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1338518003892 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1338518003893 Putative coat protein; Region: YlbD_coat; pfam14071 1338518003894 YlbE-like protein; Region: YlbE; pfam14003 1338518003895 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1338518003896 hypothetical protein; Provisional; Region: PRK02886 1338518003897 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1338518003898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518003899 S-adenosylmethionine binding site [chemical binding]; other site 1338518003900 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1338518003901 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1338518003902 active site 1338518003903 (T/H)XGH motif; other site 1338518003904 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1338518003905 Nucleoside recognition; Region: Gate; pfam07670 1338518003906 Nucleoside recognition; Region: Gate; pfam07670 1338518003907 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1338518003908 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1338518003909 active site 1338518003910 nucleophile elbow; other site 1338518003911 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1338518003912 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1338518003913 protein binding site [polypeptide binding]; other site 1338518003914 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1338518003915 hypothetical protein; Provisional; Region: PRK13670 1338518003916 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1338518003917 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1338518003918 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1338518003919 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1338518003920 hypothetical protein; Provisional; Region: PRK13688 1338518003921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518003922 Coenzyme A binding pocket [chemical binding]; other site 1338518003923 mraZ protein; Region: TIGR00242 1338518003924 MraZ protein; Region: MraZ; pfam02381 1338518003925 MraZ protein; Region: MraZ; pfam02381 1338518003926 MraW methylase family; Region: Methyltransf_5; pfam01795 1338518003927 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1338518003928 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1338518003929 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1338518003930 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1338518003931 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1338518003932 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1338518003933 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1338518003934 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1338518003935 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1338518003936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1338518003937 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1338518003938 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1338518003939 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1338518003940 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1338518003941 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1338518003942 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1338518003943 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1338518003944 Mg++ binding site [ion binding]; other site 1338518003945 putative catalytic motif [active] 1338518003946 putative substrate binding site [chemical binding]; other site 1338518003947 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1338518003948 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1338518003949 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1338518003950 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1338518003951 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1338518003952 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1338518003953 active site 1338518003954 homodimer interface [polypeptide binding]; other site 1338518003955 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1338518003956 FAD binding domain; Region: FAD_binding_4; pfam01565 1338518003957 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1338518003958 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1338518003959 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1338518003960 Cell division protein FtsQ; Region: FtsQ; pfam03799 1338518003961 cell division protein FtsA; Region: ftsA; TIGR01174 1338518003962 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1338518003963 nucleotide binding site [chemical binding]; other site 1338518003964 Cell division protein FtsA; Region: FtsA; pfam14450 1338518003965 cell division protein FtsZ; Validated; Region: PRK09330 1338518003966 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1338518003967 nucleotide binding site [chemical binding]; other site 1338518003968 SulA interaction site; other site 1338518003969 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1338518003970 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1338518003971 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1338518003972 active site 1338518003973 catalytic triad [active] 1338518003974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1338518003975 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1338518003976 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1338518003977 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1338518003978 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1338518003979 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1338518003980 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1338518003981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518003982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518003983 DNA binding residues [nucleotide binding] 1338518003984 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1338518003985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518003986 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1338518003987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518003988 DNA binding residues [nucleotide binding] 1338518003989 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1338518003990 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1338518003991 Walker A/P-loop; other site 1338518003992 ATP binding site [chemical binding]; other site 1338518003993 Q-loop/lid; other site 1338518003994 ABC transporter signature motif; other site 1338518003995 Walker B; other site 1338518003996 D-loop; other site 1338518003997 H-loop/switch region; other site 1338518003998 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1338518003999 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1338518004000 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1338518004001 catalytic residue [active] 1338518004002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1338518004003 YGGT family; Region: YGGT; pfam02325 1338518004004 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1338518004005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1338518004006 RNA binding surface [nucleotide binding]; other site 1338518004007 DivIVA protein; Region: DivIVA; pfam05103 1338518004008 DivIVA domain; Region: DivI1A_domain; TIGR03544 1338518004009 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1338518004010 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1338518004011 HIGH motif; other site 1338518004012 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1338518004013 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1338518004014 active site 1338518004015 KMSKS motif; other site 1338518004016 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1338518004017 tRNA binding surface [nucleotide binding]; other site 1338518004018 anticodon binding site; other site 1338518004019 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1338518004020 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1338518004021 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1338518004022 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1338518004023 RNA binding surface [nucleotide binding]; other site 1338518004024 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1338518004025 active site 1338518004026 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1338518004027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1338518004028 active site 1338518004029 uracil-xanthine permease; Region: ncs2; TIGR00801 1338518004030 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1338518004031 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1338518004032 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1338518004033 dihydroorotase; Validated; Region: pyrC; PRK09357 1338518004034 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1338518004035 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1338518004036 active site 1338518004037 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1338518004038 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1338518004039 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1338518004040 catalytic site [active] 1338518004041 subunit interface [polypeptide binding]; other site 1338518004042 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1338518004043 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1338518004044 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1338518004045 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1338518004046 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1338518004047 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1338518004048 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1338518004049 IMP binding site; other site 1338518004050 dimer interface [polypeptide binding]; other site 1338518004051 interdomain contacts; other site 1338518004052 partial ornithine binding site; other site 1338518004053 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1338518004054 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1338518004055 FAD binding pocket [chemical binding]; other site 1338518004056 FAD binding motif [chemical binding]; other site 1338518004057 phosphate binding motif [ion binding]; other site 1338518004058 beta-alpha-beta structure motif; other site 1338518004059 NAD binding pocket [chemical binding]; other site 1338518004060 Iron coordination center [ion binding]; other site 1338518004061 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1338518004062 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1338518004063 heterodimer interface [polypeptide binding]; other site 1338518004064 active site 1338518004065 FMN binding site [chemical binding]; other site 1338518004066 homodimer interface [polypeptide binding]; other site 1338518004067 substrate binding site [chemical binding]; other site 1338518004068 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1338518004069 active site 1338518004070 dimer interface [polypeptide binding]; other site 1338518004071 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1338518004072 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1338518004073 Active Sites [active] 1338518004074 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1338518004075 ATP-sulfurylase; Region: ATPS; cd00517 1338518004076 active site 1338518004077 HXXH motif; other site 1338518004078 flexible loop; other site 1338518004079 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1338518004080 AAA domain; Region: AAA_18; pfam13238 1338518004081 ligand-binding site [chemical binding]; other site 1338518004082 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1338518004083 diphthine synthase; Region: dph5; TIGR00522 1338518004084 active site 1338518004085 SAM binding site [chemical binding]; other site 1338518004086 homodimer interface [polypeptide binding]; other site 1338518004087 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1338518004088 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1338518004089 putative active site [active] 1338518004090 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1338518004091 putative active site [active] 1338518004092 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1338518004093 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1338518004094 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1338518004095 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1338518004096 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1338518004097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518004098 motif II; other site 1338518004099 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1338518004100 hypothetical protein; Provisional; Region: PRK11820 1338518004101 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1338518004102 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1338518004103 hypothetical protein; Provisional; Region: PRK04323 1338518004104 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1338518004105 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1338518004106 catalytic site [active] 1338518004107 G-X2-G-X-G-K; other site 1338518004108 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1338518004109 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1338518004110 Flavoprotein; Region: Flavoprotein; pfam02441 1338518004111 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1338518004112 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1338518004113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518004114 ATP binding site [chemical binding]; other site 1338518004115 putative Mg++ binding site [ion binding]; other site 1338518004116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518004117 nucleotide binding region [chemical binding]; other site 1338518004118 ATP-binding site [chemical binding]; other site 1338518004119 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1338518004120 active site 1338518004121 catalytic residues [active] 1338518004122 metal binding site [ion binding]; metal-binding site 1338518004123 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1338518004124 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1338518004125 putative RNA binding site [nucleotide binding]; other site 1338518004126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518004127 S-adenosylmethionine binding site [chemical binding]; other site 1338518004128 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1338518004129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518004130 FeS/SAM binding site; other site 1338518004131 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1338518004132 Protein phosphatase 2C; Region: PP2C; pfam00481 1338518004133 active site 1338518004134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1338518004135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1338518004136 active site 1338518004137 ATP binding site [chemical binding]; other site 1338518004138 substrate binding site [chemical binding]; other site 1338518004139 activation loop (A-loop); other site 1338518004140 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1338518004141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1338518004142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1338518004143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1338518004144 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1338518004145 GTPase RsgA; Reviewed; Region: PRK00098 1338518004146 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1338518004147 RNA binding site [nucleotide binding]; other site 1338518004148 homodimer interface [polypeptide binding]; other site 1338518004149 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1338518004150 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1338518004151 GTP/Mg2+ binding site [chemical binding]; other site 1338518004152 G4 box; other site 1338518004153 G5 box; other site 1338518004154 G1 box; other site 1338518004155 Switch I region; other site 1338518004156 G2 box; other site 1338518004157 G3 box; other site 1338518004158 Switch II region; other site 1338518004159 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1338518004160 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1338518004161 substrate binding site [chemical binding]; other site 1338518004162 hexamer interface [polypeptide binding]; other site 1338518004163 metal binding site [ion binding]; metal-binding site 1338518004164 Thiamine pyrophosphokinase; Region: TPK; cd07995 1338518004165 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1338518004166 active site 1338518004167 dimerization interface [polypeptide binding]; other site 1338518004168 thiamine binding site [chemical binding]; other site 1338518004169 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1338518004170 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1338518004171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1338518004172 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1338518004173 DAK2 domain; Region: Dak2; pfam02734 1338518004174 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1338518004175 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1338518004176 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1338518004177 putative L-serine binding site [chemical binding]; other site 1338518004178 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1338518004179 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1338518004180 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1338518004181 Y-family of DNA polymerases; Region: PolY; cl12025 1338518004182 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1338518004183 generic binding surface II; other site 1338518004184 ssDNA binding site; other site 1338518004185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518004186 ATP binding site [chemical binding]; other site 1338518004187 putative Mg++ binding site [ion binding]; other site 1338518004188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518004189 nucleotide binding region [chemical binding]; other site 1338518004190 ATP-binding site [chemical binding]; other site 1338518004191 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1338518004192 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1338518004193 putative phosphate acyltransferase; Provisional; Region: PRK05331 1338518004194 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1338518004195 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1338518004196 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1338518004197 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1338518004198 NAD(P) binding site [chemical binding]; other site 1338518004199 homotetramer interface [polypeptide binding]; other site 1338518004200 homodimer interface [polypeptide binding]; other site 1338518004201 active site 1338518004202 acyl carrier protein; Provisional; Region: acpP; PRK00982 1338518004203 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1338518004204 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1338518004205 Walker A/P-loop; other site 1338518004206 ATP binding site [chemical binding]; other site 1338518004207 Q-loop/lid; other site 1338518004208 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1338518004209 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1338518004210 ABC transporter signature motif; other site 1338518004211 Walker B; other site 1338518004212 D-loop; other site 1338518004213 H-loop/switch region; other site 1338518004214 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1338518004215 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1338518004216 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1338518004217 GTP binding site [chemical binding]; other site 1338518004218 putative DNA-binding protein; Validated; Region: PRK00118 1338518004219 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1338518004220 signal recognition particle protein; Provisional; Region: PRK10867 1338518004221 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1338518004222 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1338518004223 P loop; other site 1338518004224 GTP binding site [chemical binding]; other site 1338518004225 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1338518004226 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1338518004227 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1338518004228 KH domain; Region: KH_4; pfam13083 1338518004229 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1338518004230 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1338518004231 RimM N-terminal domain; Region: RimM; pfam01782 1338518004232 PRC-barrel domain; Region: PRC; pfam05239 1338518004233 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1338518004234 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1338518004235 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1338518004236 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1338518004237 GTP/Mg2+ binding site [chemical binding]; other site 1338518004238 G4 box; other site 1338518004239 G5 box; other site 1338518004240 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1338518004241 G1 box; other site 1338518004242 G1 box; other site 1338518004243 GTP/Mg2+ binding site [chemical binding]; other site 1338518004244 Switch I region; other site 1338518004245 G2 box; other site 1338518004246 G2 box; other site 1338518004247 G3 box; other site 1338518004248 G3 box; other site 1338518004249 Switch II region; other site 1338518004250 Switch II region; other site 1338518004251 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1338518004252 RNA/DNA hybrid binding site [nucleotide binding]; other site 1338518004253 active site 1338518004254 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1338518004255 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1338518004256 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1338518004257 CoA-ligase; Region: Ligase_CoA; pfam00549 1338518004258 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1338518004259 CoA binding domain; Region: CoA_binding; smart00881 1338518004260 CoA-ligase; Region: Ligase_CoA; pfam00549 1338518004261 DNA protecting protein DprA; Region: dprA; TIGR00732 1338518004262 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1338518004263 DNA topoisomerase I; Validated; Region: PRK05582 1338518004264 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1338518004265 active site 1338518004266 interdomain interaction site; other site 1338518004267 putative metal-binding site [ion binding]; other site 1338518004268 nucleotide binding site [chemical binding]; other site 1338518004269 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1338518004270 domain I; other site 1338518004271 DNA binding groove [nucleotide binding] 1338518004272 phosphate binding site [ion binding]; other site 1338518004273 domain II; other site 1338518004274 domain III; other site 1338518004275 nucleotide binding site [chemical binding]; other site 1338518004276 catalytic site [active] 1338518004277 domain IV; other site 1338518004278 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1338518004279 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1338518004280 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1338518004281 Glucose inhibited division protein A; Region: GIDA; pfam01134 1338518004282 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1338518004283 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1338518004284 active site 1338518004285 Int/Topo IB signature motif; other site 1338518004286 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1338518004287 active site 1338518004288 HslU subunit interaction site [polypeptide binding]; other site 1338518004289 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1338518004290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518004291 Walker A motif; other site 1338518004292 ATP binding site [chemical binding]; other site 1338518004293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1338518004294 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1338518004295 transcriptional repressor CodY; Validated; Region: PRK04158 1338518004296 CodY GAF-like domain; Region: CodY; pfam06018 1338518004297 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1338518004298 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1338518004299 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1338518004300 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1338518004301 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1338518004302 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1338518004303 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1338518004304 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1338518004305 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1338518004306 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1338518004307 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1338518004308 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1338518004309 MgtE intracellular N domain; Region: MgtE_N; smart00924 1338518004310 FliG C-terminal domain; Region: FliG_C; pfam01706 1338518004311 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1338518004312 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1338518004313 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1338518004314 Walker A motif/ATP binding site; other site 1338518004315 Walker B motif; other site 1338518004316 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1338518004317 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1338518004318 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1338518004319 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1338518004320 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1338518004321 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1338518004322 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1338518004323 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1338518004324 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1338518004325 Flagellar protein (FlbD); Region: FlbD; pfam06289 1338518004326 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1338518004327 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1338518004328 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1338518004329 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1338518004330 flagellar motor switch protein; Validated; Region: PRK08119 1338518004331 CheC-like family; Region: CheC; pfam04509 1338518004332 CheC-like family; Region: CheC; pfam04509 1338518004333 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1338518004334 Response regulator receiver domain; Region: Response_reg; pfam00072 1338518004335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518004336 active site 1338518004337 phosphorylation site [posttranslational modification] 1338518004338 intermolecular recognition site; other site 1338518004339 dimerization interface [polypeptide binding]; other site 1338518004340 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1338518004341 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1338518004342 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1338518004343 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1338518004344 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1338518004345 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1338518004346 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1338518004347 FHIPEP family; Region: FHIPEP; pfam00771 1338518004348 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1338518004349 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1338518004350 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1338518004351 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1338518004352 P-loop; other site 1338518004353 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1338518004354 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1338518004355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518004356 active site 1338518004357 phosphorylation site [posttranslational modification] 1338518004358 intermolecular recognition site; other site 1338518004359 dimerization interface [polypeptide binding]; other site 1338518004360 CheB methylesterase; Region: CheB_methylest; pfam01339 1338518004361 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1338518004362 putative CheA interaction surface; other site 1338518004363 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1338518004364 CheC-like family; Region: CheC; pfam04509 1338518004365 CheC-like family; Region: CheC; pfam04509 1338518004366 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1338518004367 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1338518004368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518004369 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1338518004370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518004371 DNA binding residues [nucleotide binding] 1338518004372 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1338518004373 rRNA interaction site [nucleotide binding]; other site 1338518004374 S8 interaction site; other site 1338518004375 putative laminin-1 binding site; other site 1338518004376 elongation factor Ts; Provisional; Region: tsf; PRK09377 1338518004377 UBA/TS-N domain; Region: UBA; pfam00627 1338518004378 Elongation factor TS; Region: EF_TS; pfam00889 1338518004379 Elongation factor TS; Region: EF_TS; pfam00889 1338518004380 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1338518004381 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1338518004382 hinge region; other site 1338518004383 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1338518004384 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1338518004385 catalytic residue [active] 1338518004386 putative FPP diphosphate binding site; other site 1338518004387 putative FPP binding hydrophobic cleft; other site 1338518004388 dimer interface [polypeptide binding]; other site 1338518004389 putative IPP diphosphate binding site; other site 1338518004390 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1338518004391 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1338518004392 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1338518004393 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1338518004394 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1338518004395 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1338518004396 RIP metalloprotease RseP; Region: TIGR00054 1338518004397 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1338518004398 active site 1338518004399 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1338518004400 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1338518004401 protein binding site [polypeptide binding]; other site 1338518004402 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1338518004403 putative substrate binding region [chemical binding]; other site 1338518004404 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1338518004405 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1338518004406 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1338518004407 generic binding surface II; other site 1338518004408 generic binding surface I; other site 1338518004409 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1338518004410 active site 1338518004411 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1338518004412 active site 1338518004413 catalytic site [active] 1338518004414 substrate binding site [chemical binding]; other site 1338518004415 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1338518004416 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1338518004417 Sm and related proteins; Region: Sm_like; cl00259 1338518004418 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1338518004419 putative oligomer interface [polypeptide binding]; other site 1338518004420 putative RNA binding site [nucleotide binding]; other site 1338518004421 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1338518004422 NusA N-terminal domain; Region: NusA_N; pfam08529 1338518004423 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1338518004424 RNA binding site [nucleotide binding]; other site 1338518004425 homodimer interface [polypeptide binding]; other site 1338518004426 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1338518004427 G-X-X-G motif; other site 1338518004428 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1338518004429 G-X-X-G motif; other site 1338518004430 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1338518004431 putative RNA binding cleft [nucleotide binding]; other site 1338518004432 hypothetical protein; Provisional; Region: PRK07714 1338518004433 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1338518004434 translation initiation factor IF-2; Region: IF-2; TIGR00487 1338518004435 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1338518004436 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1338518004437 G1 box; other site 1338518004438 putative GEF interaction site [polypeptide binding]; other site 1338518004439 GTP/Mg2+ binding site [chemical binding]; other site 1338518004440 Switch I region; other site 1338518004441 G2 box; other site 1338518004442 G3 box; other site 1338518004443 Switch II region; other site 1338518004444 G4 box; other site 1338518004445 G5 box; other site 1338518004446 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1338518004447 Translation-initiation factor 2; Region: IF-2; pfam11987 1338518004448 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1338518004449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1338518004450 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1338518004451 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1338518004452 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1338518004453 RNA binding site [nucleotide binding]; other site 1338518004454 active site 1338518004455 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1338518004456 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1338518004457 active site 1338518004458 Riboflavin kinase; Region: Flavokinase; smart00904 1338518004459 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1338518004460 16S/18S rRNA binding site [nucleotide binding]; other site 1338518004461 S13e-L30e interaction site [polypeptide binding]; other site 1338518004462 25S rRNA binding site [nucleotide binding]; other site 1338518004463 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1338518004464 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1338518004465 NodB motif; other site 1338518004466 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1338518004467 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1338518004468 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1338518004469 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1338518004470 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1338518004471 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1338518004472 NAD binding site [chemical binding]; other site 1338518004473 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1338518004474 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1338518004475 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1338518004476 aspartate kinase I; Reviewed; Region: PRK08210 1338518004477 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1338518004478 putative catalytic residues [active] 1338518004479 putative nucleotide binding site [chemical binding]; other site 1338518004480 putative aspartate binding site [chemical binding]; other site 1338518004481 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1338518004482 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1338518004483 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1338518004484 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1338518004485 dimer interface [polypeptide binding]; other site 1338518004486 active site 1338518004487 catalytic residue [active] 1338518004488 Clp protease; Region: CLP_protease; pfam00574 1338518004489 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1338518004490 active site 1338518004491 YlzJ-like protein; Region: YlzJ; pfam14035 1338518004492 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1338518004493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518004494 DNA-binding site [nucleotide binding]; DNA binding site 1338518004495 UTRA domain; Region: UTRA; pfam07702 1338518004496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518004497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518004498 putative substrate translocation pore; other site 1338518004499 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518004500 MarR family; Region: MarR_2; pfam12802 1338518004501 MMPL family; Region: MMPL; pfam03176 1338518004502 Predicted membrane protein [Function unknown]; Region: COG1511 1338518004503 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1338518004504 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1338518004505 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1338518004506 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1338518004507 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1338518004508 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1338518004509 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1338518004510 classical (c) SDRs; Region: SDR_c; cd05233 1338518004511 NAD(P) binding site [chemical binding]; other site 1338518004512 active site 1338518004513 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1338518004514 ACT domain; Region: ACT; pfam01842 1338518004515 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1338518004516 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1338518004517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518004518 non-specific DNA binding site [nucleotide binding]; other site 1338518004519 salt bridge; other site 1338518004520 sequence-specific DNA binding site [nucleotide binding]; other site 1338518004521 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1338518004522 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1338518004523 competence damage-inducible protein A; Provisional; Region: PRK00549 1338518004524 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1338518004525 putative MPT binding site; other site 1338518004526 Competence-damaged protein; Region: CinA; pfam02464 1338518004527 recombinase A; Provisional; Region: recA; PRK09354 1338518004528 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1338518004529 hexamer interface [polypeptide binding]; other site 1338518004530 Walker A motif; other site 1338518004531 ATP binding site [chemical binding]; other site 1338518004532 Walker B motif; other site 1338518004533 Beta-lactamase; Region: Beta-lactamase; pfam00144 1338518004534 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1338518004535 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1338518004536 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1338518004537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518004538 Zn2+ binding site [ion binding]; other site 1338518004539 Mg2+ binding site [ion binding]; other site 1338518004540 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1338518004541 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1338518004542 putative active site [active] 1338518004543 metal binding site [ion binding]; metal-binding site 1338518004544 homodimer binding site [polypeptide binding]; other site 1338518004545 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1338518004546 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1338518004547 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1338518004548 substrate-cofactor binding pocket; other site 1338518004549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518004550 catalytic residue [active] 1338518004551 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1338518004552 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1338518004553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518004554 FeS/SAM binding site; other site 1338518004555 TRAM domain; Region: TRAM; pfam01938 1338518004556 Predicted membrane protein [Function unknown]; Region: COG4550 1338518004557 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1338518004558 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1338518004559 MutS domain I; Region: MutS_I; pfam01624 1338518004560 MutS domain II; Region: MutS_II; pfam05188 1338518004561 MutS domain III; Region: MutS_III; pfam05192 1338518004562 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1338518004563 Walker A/P-loop; other site 1338518004564 ATP binding site [chemical binding]; other site 1338518004565 Q-loop/lid; other site 1338518004566 ABC transporter signature motif; other site 1338518004567 Walker B; other site 1338518004568 D-loop; other site 1338518004569 H-loop/switch region; other site 1338518004570 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1338518004571 Int/Topo IB signature motif; other site 1338518004572 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1338518004573 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1338518004574 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1338518004575 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1338518004576 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1338518004577 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1338518004578 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1338518004579 FMN binding site [chemical binding]; other site 1338518004580 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1338518004581 substrate binding site [chemical binding]; other site 1338518004582 putative catalytic residue [active] 1338518004583 acyl carrier protein; Validated; Region: PRK07117 1338518004584 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1338518004585 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1338518004586 dimer interface [polypeptide binding]; other site 1338518004587 active site 1338518004588 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1338518004589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1338518004590 substrate binding site [chemical binding]; other site 1338518004591 oxyanion hole (OAH) forming residues; other site 1338518004592 trimer interface [polypeptide binding]; other site 1338518004593 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518004594 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1338518004595 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518004596 active site 1338518004597 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518004598 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518004599 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518004600 putative NADP binding site [chemical binding]; other site 1338518004601 active site 1338518004602 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518004603 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518004604 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518004605 active site 1338518004606 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518004607 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518004608 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518004609 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518004610 active site 1338518004611 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518004612 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518004613 putative NADP binding site [chemical binding]; other site 1338518004614 active site 1338518004615 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518004616 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518004617 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518004618 active site 1338518004619 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1338518004620 Cytochrome P450; Region: p450; cl12078 1338518004621 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1338518004622 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1338518004623 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1338518004624 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1338518004625 active site 1338518004626 catalytic triad [active] 1338518004627 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1338518004628 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1338518004629 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1338518004630 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1338518004631 YmaF family; Region: YmaF; pfam12788 1338518004632 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1338518004633 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1338518004634 bacterial Hfq-like; Region: Hfq; cd01716 1338518004635 hexamer interface [polypeptide binding]; other site 1338518004636 Sm1 motif; other site 1338518004637 RNA binding site [nucleotide binding]; other site 1338518004638 Sm2 motif; other site 1338518004639 YmzC-like protein; Region: YmzC; pfam14157 1338518004640 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1338518004641 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1338518004642 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1338518004643 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1338518004644 active site 1338518004645 dimer interface [polypeptide binding]; other site 1338518004646 catalytic residues [active] 1338518004647 effector binding site; other site 1338518004648 R2 peptide binding site; other site 1338518004649 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1338518004650 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1338518004651 dimer interface [polypeptide binding]; other site 1338518004652 putative radical transfer pathway; other site 1338518004653 diiron center [ion binding]; other site 1338518004654 tyrosyl radical; other site 1338518004655 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1338518004656 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1338518004657 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1338518004658 active site 1338518004659 metal binding site [ion binding]; metal-binding site 1338518004660 Sporulation related domain; Region: SPOR; cl10051 1338518004661 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1338518004662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518004663 Walker A motif; other site 1338518004664 ATP binding site [chemical binding]; other site 1338518004665 Walker B motif; other site 1338518004666 arginine finger; other site 1338518004667 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1338518004668 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1338518004669 HflX GTPase family; Region: HflX; cd01878 1338518004670 G1 box; other site 1338518004671 GTP/Mg2+ binding site [chemical binding]; other site 1338518004672 Switch I region; other site 1338518004673 G2 box; other site 1338518004674 G3 box; other site 1338518004675 Switch II region; other site 1338518004676 G4 box; other site 1338518004677 G5 box; other site 1338518004678 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1338518004679 Aluminium resistance protein; Region: Alum_res; pfam06838 1338518004680 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1338518004681 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1338518004682 DNA binding residues [nucleotide binding] 1338518004683 glutamine synthetase, type I; Region: GlnA; TIGR00653 1338518004684 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1338518004685 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1338518004686 Major royal jelly protein; Region: MRJP; pfam03022 1338518004687 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1338518004688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518004689 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1338518004690 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1338518004691 inhibitor binding site; inhibition site 1338518004692 active site 1338518004693 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1338518004694 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1338518004695 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1338518004696 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1338518004697 nucleotide binding site [chemical binding]; other site 1338518004698 xylose isomerase; Provisional; Region: PRK05474 1338518004699 xylose isomerase; Region: xylose_isom_A; TIGR02630 1338518004700 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1338518004701 N- and C-terminal domain interface [polypeptide binding]; other site 1338518004702 D-xylulose kinase; Region: XylB; TIGR01312 1338518004703 active site 1338518004704 MgATP binding site [chemical binding]; other site 1338518004705 catalytic site [active] 1338518004706 metal binding site [ion binding]; metal-binding site 1338518004707 xylulose binding site [chemical binding]; other site 1338518004708 homodimer interface [polypeptide binding]; other site 1338518004709 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1338518004710 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1338518004711 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1338518004712 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1338518004713 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1338518004714 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1338518004715 NAD binding site [chemical binding]; other site 1338518004716 substrate binding site [chemical binding]; other site 1338518004717 catalytic Zn binding site [ion binding]; other site 1338518004718 tetramer interface [polypeptide binding]; other site 1338518004719 structural Zn binding site [ion binding]; other site 1338518004720 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1338518004721 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1338518004722 Coenzyme A binding pocket [chemical binding]; other site 1338518004723 YoaP-like; Region: YoaP; pfam14268 1338518004724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1338518004725 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1338518004726 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 1338518004727 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1338518004728 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1338518004729 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1338518004730 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1338518004731 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1338518004732 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1338518004733 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1338518004734 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1338518004735 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1338518004736 trimer interface [polypeptide binding]; other site 1338518004737 active site 1338518004738 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1338518004739 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1338518004740 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1338518004741 LexA repressor; Validated; Region: PRK00215 1338518004742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518004743 putative DNA binding site [nucleotide binding]; other site 1338518004744 putative Zn2+ binding site [ion binding]; other site 1338518004745 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1338518004746 Catalytic site [active] 1338518004747 cell division suppressor protein YneA; Provisional; Region: PRK14125 1338518004748 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518004749 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1338518004750 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1338518004751 catalytic residues [active] 1338518004752 catalytic nucleophile [active] 1338518004753 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1338518004754 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1338518004755 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1338518004756 TPP-binding site [chemical binding]; other site 1338518004757 dimer interface [polypeptide binding]; other site 1338518004758 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1338518004759 PYR/PP interface [polypeptide binding]; other site 1338518004760 dimer interface [polypeptide binding]; other site 1338518004761 TPP binding site [chemical binding]; other site 1338518004762 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1338518004763 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1338518004764 hypothetical protein; Provisional; Region: PRK01844 1338518004765 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1338518004766 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1338518004767 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1338518004768 Response regulator receiver domain; Region: Response_reg; pfam00072 1338518004769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518004770 active site 1338518004771 phosphorylation site [posttranslational modification] 1338518004772 intermolecular recognition site; other site 1338518004773 dimerization interface [polypeptide binding]; other site 1338518004774 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1338518004775 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1338518004776 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1338518004777 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1338518004778 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1338518004779 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1338518004780 aconitate hydratase; Validated; Region: PRK09277 1338518004781 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1338518004782 substrate binding site [chemical binding]; other site 1338518004783 ligand binding site [chemical binding]; other site 1338518004784 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1338518004785 substrate binding site [chemical binding]; other site 1338518004786 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1338518004787 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1338518004788 catalytic residues [active] 1338518004789 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1338518004790 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1338518004791 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1338518004792 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1338518004793 active site 1338518004794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1338518004795 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1338518004796 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1338518004797 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1338518004798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518004799 ATP binding site [chemical binding]; other site 1338518004800 Mg2+ binding site [ion binding]; other site 1338518004801 G-X-G motif; other site 1338518004802 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1338518004803 anchoring element; other site 1338518004804 dimer interface [polypeptide binding]; other site 1338518004805 ATP binding site [chemical binding]; other site 1338518004806 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1338518004807 active site 1338518004808 putative metal-binding site [ion binding]; other site 1338518004809 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1338518004810 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1338518004811 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1338518004812 CAP-like domain; other site 1338518004813 active site 1338518004814 primary dimer interface [polypeptide binding]; other site 1338518004815 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518004816 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518004817 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518004818 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1338518004819 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1338518004820 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1338518004821 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1338518004822 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1338518004823 substrate binding site [chemical binding]; other site 1338518004824 ATP binding site [chemical binding]; other site 1338518004825 putative oxidoreductase; Provisional; Region: PRK10083 1338518004826 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1338518004827 putative NAD(P) binding site [chemical binding]; other site 1338518004828 catalytic Zn binding site [ion binding]; other site 1338518004829 structural Zn binding site [ion binding]; other site 1338518004830 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1338518004831 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1338518004832 active site 1338518004833 intersubunit interface [polypeptide binding]; other site 1338518004834 catalytic residue [active] 1338518004835 mannonate dehydratase; Provisional; Region: PRK03906 1338518004836 mannonate dehydratase; Region: uxuA; TIGR00695 1338518004837 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1338518004838 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1338518004839 putative NAD(P) binding site [chemical binding]; other site 1338518004840 active site 1338518004841 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518004842 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518004843 DNA binding site [nucleotide binding] 1338518004844 domain linker motif; other site 1338518004845 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1338518004846 putative dimerization interface [polypeptide binding]; other site 1338518004847 putative ligand binding site [chemical binding]; other site 1338518004848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518004849 D-galactonate transporter; Region: 2A0114; TIGR00893 1338518004850 putative substrate translocation pore; other site 1338518004851 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1338518004852 YndJ-like protein; Region: YndJ; pfam14158 1338518004853 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1338518004854 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1338518004855 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1338518004856 Cellulose binding domain; Region: CBM_3; pfam00942 1338518004857 Tic20-like protein; Region: Tic20; pfam09685 1338518004858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518004859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1338518004860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518004861 dimer interface [polypeptide binding]; other site 1338518004862 phosphorylation site [posttranslational modification] 1338518004863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518004864 ATP binding site [chemical binding]; other site 1338518004865 Mg2+ binding site [ion binding]; other site 1338518004866 G-X-G motif; other site 1338518004867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518004868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518004869 active site 1338518004870 phosphorylation site [posttranslational modification] 1338518004871 intermolecular recognition site; other site 1338518004872 dimerization interface [polypeptide binding]; other site 1338518004873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518004874 DNA binding site [nucleotide binding] 1338518004875 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1338518004876 substrate binding site [chemical binding]; other site 1338518004877 active site 1338518004878 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1338518004879 metal binding site [ion binding]; metal-binding site 1338518004880 ligand binding site [chemical binding]; other site 1338518004881 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1338518004882 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1338518004883 acyl-activating enzyme (AAE) consensus motif; other site 1338518004884 AMP binding site [chemical binding]; other site 1338518004885 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518004886 Condensation domain; Region: Condensation; pfam00668 1338518004887 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1338518004888 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1338518004889 Condensation domain; Region: Condensation; pfam00668 1338518004890 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1338518004891 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1338518004892 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1338518004893 acyl-activating enzyme (AAE) consensus motif; other site 1338518004894 AMP binding site [chemical binding]; other site 1338518004895 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518004896 Thioesterase domain; Region: Thioesterase; pfam00975 1338518004897 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1338518004898 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1338518004899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518004900 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1338518004901 NAD(P) binding site [chemical binding]; other site 1338518004902 active site 1338518004903 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1338518004904 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1338518004905 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1338518004906 Cytochrome P450; Region: p450; cl12078 1338518004907 biotin synthase; Validated; Region: PRK06256 1338518004908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518004909 FeS/SAM binding site; other site 1338518004910 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1338518004911 AAA domain; Region: AAA_26; pfam13500 1338518004912 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1338518004913 active site 1338518004914 ADP binding site [chemical binding]; other site 1338518004915 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1338518004916 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1338518004917 substrate-cofactor binding pocket; other site 1338518004918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518004919 catalytic residue [active] 1338518004920 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1338518004921 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518004922 inhibitor-cofactor binding pocket; inhibition site 1338518004923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518004924 catalytic residue [active] 1338518004925 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1338518004926 Predicted membrane protein [Function unknown]; Region: COG2246 1338518004927 GtrA-like protein; Region: GtrA; pfam04138 1338518004928 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1338518004929 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1338518004930 active site 1338518004931 tetramer interface; other site 1338518004932 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1338518004933 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1338518004934 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1338518004935 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1338518004936 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1338518004937 enoyl-CoA hydratase; Provisional; Region: PRK07657 1338518004938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1338518004939 substrate binding site [chemical binding]; other site 1338518004940 oxyanion hole (OAH) forming residues; other site 1338518004941 trimer interface [polypeptide binding]; other site 1338518004942 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1338518004943 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1338518004944 active site 1338518004945 catalytic residues [active] 1338518004946 metal binding site [ion binding]; metal-binding site 1338518004947 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1338518004948 carboxyltransferase (CT) interaction site; other site 1338518004949 biotinylation site [posttranslational modification]; other site 1338518004950 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1338518004951 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1338518004952 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1338518004953 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1338518004954 AMP-binding domain protein; Validated; Region: PRK08315 1338518004955 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1338518004956 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1338518004957 acyl-activating enzyme (AAE) consensus motif; other site 1338518004958 putative AMP binding site [chemical binding]; other site 1338518004959 putative active site [active] 1338518004960 putative CoA binding site [chemical binding]; other site 1338518004961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1338518004962 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1338518004963 FAD binding site [chemical binding]; other site 1338518004964 homotetramer interface [polypeptide binding]; other site 1338518004965 substrate binding pocket [chemical binding]; other site 1338518004966 catalytic base [active] 1338518004967 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1338518004968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1338518004969 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1338518004970 Condensation domain; Region: Condensation; pfam00668 1338518004971 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1338518004972 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1338518004973 acyl-activating enzyme (AAE) consensus motif; other site 1338518004974 AMP binding site [chemical binding]; other site 1338518004975 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518004976 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1338518004977 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1338518004978 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1338518004979 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1338518004980 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1338518004981 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1338518004982 Int/Topo IB signature motif; other site 1338518004983 Helix-turn-helix domain; Region: HTH_17; cl17695 1338518004984 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1338518004985 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1338518004986 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1338518004987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518004988 putative substrate translocation pore; other site 1338518004989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518004990 dimerization interface [polypeptide binding]; other site 1338518004991 putative DNA binding site [nucleotide binding]; other site 1338518004992 putative Zn2+ binding site [ion binding]; other site 1338518004993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518004994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518004995 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1338518004996 putative dimerization interface [polypeptide binding]; other site 1338518004997 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1338518004998 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1338518004999 NAD(P) binding site [chemical binding]; other site 1338518005000 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1338518005001 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1338518005002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518005003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518005004 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1338518005005 putative dimerization interface [polypeptide binding]; other site 1338518005006 gamma-glutamyl kinase; Provisional; Region: PRK13402 1338518005007 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1338518005008 nucleotide binding site [chemical binding]; other site 1338518005009 homotetrameric interface [polypeptide binding]; other site 1338518005010 putative phosphate binding site [ion binding]; other site 1338518005011 putative allosteric binding site; other site 1338518005012 Replication terminator protein; Region: RTP; pfam02334 1338518005013 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1338518005014 classical (c) SDRs; Region: SDR_c; cd05233 1338518005015 NAD(P) binding site [chemical binding]; other site 1338518005016 active site 1338518005017 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1338518005018 polyol permease family; Region: 2A0118; TIGR00897 1338518005019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518005020 putative substrate translocation pore; other site 1338518005021 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1338518005022 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1338518005023 nucleotide binding site [chemical binding]; other site 1338518005024 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1338518005025 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1338518005026 putative ligand binding site [chemical binding]; other site 1338518005027 putative NAD binding site [chemical binding]; other site 1338518005028 catalytic site [active] 1338518005029 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1338518005030 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1338518005031 putative [4Fe-4S] binding site [ion binding]; other site 1338518005032 putative molybdopterin cofactor binding site [chemical binding]; other site 1338518005033 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1338518005034 putative molybdopterin cofactor binding site; other site 1338518005035 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518005036 MarR family; Region: MarR_2; pfam12802 1338518005037 MarR family; Region: MarR_2; cl17246 1338518005038 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1338518005039 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1338518005040 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1338518005041 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1338518005042 dimer interface [polypeptide binding]; other site 1338518005043 putative tRNA-binding site [nucleotide binding]; other site 1338518005044 Cupin domain; Region: Cupin_2; pfam07883 1338518005045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518005046 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1338518005047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518005048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518005049 WHG domain; Region: WHG; pfam13305 1338518005050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518005051 dimerization interface [polypeptide binding]; other site 1338518005052 putative DNA binding site [nucleotide binding]; other site 1338518005053 putative Zn2+ binding site [ion binding]; other site 1338518005054 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1338518005055 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1338518005056 catalytic residue [active] 1338518005057 Predicted membrane protein [Function unknown]; Region: COG2322 1338518005058 Protein required for attachment to host cells; Region: Host_attach; cl02398 1338518005059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1338518005060 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1338518005061 putative dimer interface [polypeptide binding]; other site 1338518005062 catalytic triad [active] 1338518005063 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518005064 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518005065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1338518005066 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1338518005067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518005068 ATP binding site [chemical binding]; other site 1338518005069 putative Mg++ binding site [ion binding]; other site 1338518005070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518005071 nucleotide binding region [chemical binding]; other site 1338518005072 ATP-binding site [chemical binding]; other site 1338518005073 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1338518005074 HRDC domain; Region: HRDC; pfam00570 1338518005075 azoreductase; Provisional; Region: PRK13556 1338518005076 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1338518005077 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1338518005078 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1338518005079 putative dimer interface [polypeptide binding]; other site 1338518005080 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1338518005081 pentamer interface [polypeptide binding]; other site 1338518005082 dodecaamer interface [polypeptide binding]; other site 1338518005083 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1338518005084 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1338518005085 NAD(P) binding site [chemical binding]; other site 1338518005086 catalytic residues [active] 1338518005087 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1338518005088 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1338518005089 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1338518005090 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1338518005091 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1338518005092 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1338518005093 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1338518005094 Na2 binding site [ion binding]; other site 1338518005095 putative substrate binding site 1 [chemical binding]; other site 1338518005096 Na binding site 1 [ion binding]; other site 1338518005097 putative substrate binding site 2 [chemical binding]; other site 1338518005098 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1338518005099 Sodium Bile acid symporter family; Region: SBF; pfam01758 1338518005100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1338518005101 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1338518005102 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1338518005103 E3 interaction surface; other site 1338518005104 lipoyl attachment site [posttranslational modification]; other site 1338518005105 e3 binding domain; Region: E3_binding; pfam02817 1338518005106 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1338518005107 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1338518005108 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1338518005109 TPP-binding site [chemical binding]; other site 1338518005110 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1338518005111 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1338518005112 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1338518005113 metal ion-dependent adhesion site (MIDAS); other site 1338518005114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518005115 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1338518005116 Walker A motif; other site 1338518005117 ATP binding site [chemical binding]; other site 1338518005118 Walker B motif; other site 1338518005119 arginine finger; other site 1338518005120 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1338518005121 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1338518005122 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1338518005123 E-class dimer interface [polypeptide binding]; other site 1338518005124 P-class dimer interface [polypeptide binding]; other site 1338518005125 active site 1338518005126 Cu2+ binding site [ion binding]; other site 1338518005127 Zn2+ binding site [ion binding]; other site 1338518005128 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518005129 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1338518005130 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518005131 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1338518005132 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518005133 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1338518005134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518005135 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1338518005136 NlpC/P60 family; Region: NLPC_P60; pfam00877 1338518005137 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1338518005138 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1338518005139 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1338518005140 multidrug efflux protein; Reviewed; Region: PRK01766 1338518005141 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1338518005142 cation binding site [ion binding]; other site 1338518005143 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1338518005144 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1338518005145 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1338518005146 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1338518005147 EamA-like transporter family; Region: EamA; pfam00892 1338518005148 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1338518005149 Predicted transcriptional regulators [Transcription]; Region: COG1733 1338518005150 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518005151 dimerization interface [polypeptide binding]; other site 1338518005152 putative DNA binding site [nucleotide binding]; other site 1338518005153 putative Zn2+ binding site [ion binding]; other site 1338518005154 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1338518005155 dimer interface [polypeptide binding]; other site 1338518005156 FMN binding site [chemical binding]; other site 1338518005157 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1338518005158 Na binding site [ion binding]; other site 1338518005159 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1338518005160 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1338518005161 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1338518005162 beta-galactosidase; Region: BGL; TIGR03356 1338518005163 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1338518005164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518005165 DNA-binding site [nucleotide binding]; DNA binding site 1338518005166 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1338518005167 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1338518005168 C-terminal peptidase (prc); Region: prc; TIGR00225 1338518005169 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1338518005170 protein binding site [polypeptide binding]; other site 1338518005171 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1338518005172 Catalytic dyad [active] 1338518005173 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1338518005174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518005175 S-adenosylmethionine binding site [chemical binding]; other site 1338518005176 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1338518005177 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1338518005178 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1338518005179 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1338518005180 YodL-like; Region: YodL; pfam14191 1338518005181 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1338518005182 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1338518005183 active site 1338518005184 YozD-like protein; Region: YozD; pfam14162 1338518005185 hypothetical protein; Provisional; Region: PRK13672 1338518005186 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1338518005187 Zn binding site [ion binding]; other site 1338518005188 toxin interface [polypeptide binding]; other site 1338518005189 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1338518005190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518005191 FeS/SAM binding site; other site 1338518005192 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1338518005193 acetylornithine deacetylase; Validated; Region: PRK06915 1338518005194 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1338518005195 metal binding site [ion binding]; metal-binding site 1338518005196 dimer interface [polypeptide binding]; other site 1338518005197 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1338518005198 hypothetical protein; Provisional; Region: PRK06917 1338518005199 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518005200 inhibitor-cofactor binding pocket; inhibition site 1338518005201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518005202 catalytic residue [active] 1338518005203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518005204 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1338518005205 Coenzyme A binding pocket [chemical binding]; other site 1338518005206 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1338518005207 active site 1338518005208 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1338518005209 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1338518005210 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1338518005211 Phytase; Region: Phytase; cl17685 1338518005212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518005213 NAD(P) binding site [chemical binding]; other site 1338518005214 active site 1338518005215 YoqO-like protein; Region: YoqO; pfam14037 1338518005216 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518005217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518005218 Coenzyme A binding pocket [chemical binding]; other site 1338518005219 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1338518005220 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1338518005221 Staphylococcal nuclease homologues; Region: SNc; smart00318 1338518005222 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1338518005223 Catalytic site; other site 1338518005224 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1338518005225 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1338518005226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518005227 active site 1338518005228 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1338518005229 SelR domain; Region: SelR; pfam01641 1338518005230 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1338518005231 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518005232 MarR family; Region: MarR; pfam01047 1338518005233 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1338518005234 active site 1338518005235 catalytic triad [active] 1338518005236 oxyanion hole [active] 1338518005237 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1338518005238 threonine dehydratase; Validated; Region: PRK08639 1338518005239 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1338518005240 tetramer interface [polypeptide binding]; other site 1338518005241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518005242 catalytic residue [active] 1338518005243 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1338518005244 putative Ile/Val binding site [chemical binding]; other site 1338518005245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518005246 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1338518005247 Walker A motif; other site 1338518005248 ATP binding site [chemical binding]; other site 1338518005249 Walker B motif; other site 1338518005250 arginine finger; other site 1338518005251 Haemolysin-III related; Region: HlyIII; cl03831 1338518005252 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1338518005253 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1338518005254 putative acyl-acceptor binding pocket; other site 1338518005255 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1338518005256 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1338518005257 folate binding site [chemical binding]; other site 1338518005258 NADP+ binding site [chemical binding]; other site 1338518005259 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1338518005260 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1338518005261 dimerization interface [polypeptide binding]; other site 1338518005262 active site 1338518005263 YpjP-like protein; Region: YpjP; pfam14005 1338518005264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1338518005265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518005266 S-adenosylmethionine binding site [chemical binding]; other site 1338518005267 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1338518005268 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1338518005269 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1338518005270 Virulence factor; Region: Virulence_fact; pfam13769 1338518005271 HEAT repeats; Region: HEAT_2; pfam13646 1338518005272 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1338518005273 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1338518005274 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518005275 Zn2+ binding site [ion binding]; other site 1338518005276 Mg2+ binding site [ion binding]; other site 1338518005277 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1338518005278 catalytic residues [active] 1338518005279 dimer interface [polypeptide binding]; other site 1338518005280 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1338518005281 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1338518005282 proposed active site lysine [active] 1338518005283 conserved cys residue [active] 1338518005284 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1338518005285 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1338518005286 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1338518005287 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1338518005288 DNA-binding site [nucleotide binding]; DNA binding site 1338518005289 RNA-binding motif; other site 1338518005290 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1338518005291 hypothetical protein; Validated; Region: PRK07708 1338518005292 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1338518005293 RNA/DNA hybrid binding site [nucleotide binding]; other site 1338518005294 active site 1338518005295 conserved hypothetical integral membrane protein; Region: TIGR00697 1338518005296 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1338518005297 5'-3' exonuclease; Region: 53EXOc; smart00475 1338518005298 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1338518005299 active site 1338518005300 metal binding site 1 [ion binding]; metal-binding site 1338518005301 putative 5' ssDNA interaction site; other site 1338518005302 metal binding site 3; metal-binding site 1338518005303 metal binding site 2 [ion binding]; metal-binding site 1338518005304 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1338518005305 putative DNA binding site [nucleotide binding]; other site 1338518005306 putative metal binding site [ion binding]; other site 1338518005307 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1338518005308 Dynamin family; Region: Dynamin_N; pfam00350 1338518005309 G1 box; other site 1338518005310 GTP/Mg2+ binding site [chemical binding]; other site 1338518005311 G2 box; other site 1338518005312 Switch I region; other site 1338518005313 G3 box; other site 1338518005314 Switch II region; other site 1338518005315 G4 box; other site 1338518005316 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1338518005317 G1 box; other site 1338518005318 GTP/Mg2+ binding site [chemical binding]; other site 1338518005319 Dynamin family; Region: Dynamin_N; pfam00350 1338518005320 G2 box; other site 1338518005321 Switch I region; other site 1338518005322 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1338518005323 G3 box; other site 1338518005324 Switch II region; other site 1338518005325 GTP/Mg2+ binding site [chemical binding]; other site 1338518005326 G4 box; other site 1338518005327 G5 box; other site 1338518005328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1338518005329 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1338518005330 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1338518005331 malonyl-CoA binding site [chemical binding]; other site 1338518005332 dimer interface [polypeptide binding]; other site 1338518005333 active site 1338518005334 product binding site; other site 1338518005335 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1338518005336 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1338518005337 DNA binding site [nucleotide binding] 1338518005338 active site 1338518005339 Predicted membrane protein [Function unknown]; Region: COG2323 1338518005340 Isochorismatase family; Region: Isochorismatase; pfam00857 1338518005341 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1338518005342 catalytic triad [active] 1338518005343 conserved cis-peptide bond; other site 1338518005344 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:9098051, 8969496, 9384377; Product type t:transporter 1338518005347 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; Product type e:enzyme 1338518005348 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:8969495, 9465078; Product type e:enzyme 1338518005349 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:8969495, 9465078; Product type e:enzyme 1338518005350 YorP protein; Region: YorP; pfam09629 1338518005351 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:putative enzyme 1338518005352 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:putative enzyme 1338518005353 Evidence 4:Homologs of previously reported genes of unknown function 1338518005354 Evidence 4:Homologs of previously reported genes of unknown function 1338518005355 YonK protein; Region: YonK; pfam09642 1338518005356 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1338518005357 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1338518005358 active site 1338518005359 catalytic residues [active] 1338518005360 DNA binding site [nucleotide binding] 1338518005361 Int/Topo IB signature motif; other site 1338518005362 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:10931330, 20980266; Product type h:extrachromosomal origin 1338518005363 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:10931330, 20980266; Product type h:extrachromosomal origin 1338518005364 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1338518005365 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:12923093, 15549109, 15849754, 16850406; Product type t:transporter 1338518005366 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1338518005367 active site 1338518005368 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1338518005369 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1338518005370 active site 1338518005371 Zn binding site [ion binding]; other site 1338518005372 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1338518005373 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1338518005374 YpzG-like protein; Region: YpzG; pfam14139 1338518005375 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1338518005376 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1338518005377 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1338518005378 cell division protein GpsB; Provisional; Region: PRK14127 1338518005379 DivIVA domain; Region: DivI1A_domain; TIGR03544 1338518005380 hypothetical protein; Provisional; Region: PRK13660 1338518005381 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1338518005382 RNase_H superfamily; Region: RNase_H_2; pfam13482 1338518005383 active site 1338518005384 substrate binding site [chemical binding]; other site 1338518005385 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1338518005386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518005387 ATP binding site [chemical binding]; other site 1338518005388 putative Mg++ binding site [ion binding]; other site 1338518005389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518005390 nucleotide binding region [chemical binding]; other site 1338518005391 ATP-binding site [chemical binding]; other site 1338518005392 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1338518005393 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1338518005394 HPr interaction site; other site 1338518005395 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1338518005396 active site 1338518005397 phosphorylation site [posttranslational modification] 1338518005398 YppG-like protein; Region: YppG; pfam14179 1338518005399 YppF-like protein; Region: YppF; pfam14178 1338518005400 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1338518005401 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1338518005402 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1338518005403 Transglycosylase; Region: Transgly; pfam00912 1338518005404 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1338518005405 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1338518005406 Interdomain contacts; other site 1338518005407 Cytokine receptor motif; other site 1338518005408 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1338518005409 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1338518005410 minor groove reading motif; other site 1338518005411 helix-hairpin-helix signature motif; other site 1338518005412 substrate binding pocket [chemical binding]; other site 1338518005413 active site 1338518005414 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1338518005415 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1338518005416 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1338518005417 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1338518005418 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1338518005419 putative dimer interface [polypeptide binding]; other site 1338518005420 putative anticodon binding site; other site 1338518005421 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1338518005422 homodimer interface [polypeptide binding]; other site 1338518005423 motif 1; other site 1338518005424 motif 2; other site 1338518005425 active site 1338518005426 motif 3; other site 1338518005427 aspartate aminotransferase; Provisional; Region: PRK05764 1338518005428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518005429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518005430 homodimer interface [polypeptide binding]; other site 1338518005431 catalytic residue [active] 1338518005432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1338518005433 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1338518005434 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1338518005435 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1338518005436 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1338518005437 active site 1338518005438 catalytic site [active] 1338518005439 substrate binding site [chemical binding]; other site 1338518005440 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1338518005441 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1338518005442 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1338518005443 tetramerization interface [polypeptide binding]; other site 1338518005444 active site 1338518005445 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1338518005446 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1338518005447 active site 1338518005448 ATP-binding site [chemical binding]; other site 1338518005449 pantoate-binding site; other site 1338518005450 HXXH motif; other site 1338518005451 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1338518005452 oligomerization interface [polypeptide binding]; other site 1338518005453 active site 1338518005454 metal binding site [ion binding]; metal-binding site 1338518005455 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1338518005456 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1338518005457 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1338518005458 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1338518005459 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1338518005460 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1338518005461 active site 1338518005462 NTP binding site [chemical binding]; other site 1338518005463 metal binding triad [ion binding]; metal-binding site 1338518005464 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1338518005465 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1338518005466 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1338518005467 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1338518005468 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1338518005469 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1338518005470 active site 1338518005471 dimer interfaces [polypeptide binding]; other site 1338518005472 catalytic residues [active] 1338518005473 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1338518005474 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1338518005475 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1338518005476 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1338518005477 homodimer interface [polypeptide binding]; other site 1338518005478 metal binding site [ion binding]; metal-binding site 1338518005479 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1338518005480 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518005481 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518005482 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1338518005483 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 1338518005484 Qo binding site; other site 1338518005485 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1338518005486 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1338518005487 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1338518005488 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1338518005489 hypothetical protein; Provisional; Region: PRK03636 1338518005490 UPF0302 domain; Region: UPF0302; pfam08864 1338518005491 A short protein domain of unknown function; Region: IDEAL; smart00914 1338518005492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1338518005493 TPR motif; other site 1338518005494 binding surface 1338518005495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1338518005496 binding surface 1338518005497 TPR motif; other site 1338518005498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518005499 TPR motif; other site 1338518005500 binding surface 1338518005501 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1338518005502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518005503 binding surface 1338518005504 TPR motif; other site 1338518005505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1338518005506 binding surface 1338518005507 TPR motif; other site 1338518005508 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1338518005509 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1338518005510 hinge; other site 1338518005511 active site 1338518005512 prephenate dehydrogenase; Validated; Region: PRK06545 1338518005513 prephenate dehydrogenase; Validated; Region: PRK08507 1338518005514 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1338518005515 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1338518005516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518005517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518005518 homodimer interface [polypeptide binding]; other site 1338518005519 catalytic residue [active] 1338518005520 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1338518005521 substrate binding site [chemical binding]; other site 1338518005522 active site 1338518005523 catalytic residues [active] 1338518005524 heterodimer interface [polypeptide binding]; other site 1338518005525 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1338518005526 active site 1338518005527 ribulose/triose binding site [chemical binding]; other site 1338518005528 phosphate binding site [ion binding]; other site 1338518005529 substrate (anthranilate) binding pocket [chemical binding]; other site 1338518005530 product (indole) binding pocket [chemical binding]; other site 1338518005531 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1338518005532 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1338518005533 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1338518005534 anthranilate synthase component I; Provisional; Region: PRK13569 1338518005535 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1338518005536 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1338518005537 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1338518005538 active site 1338518005539 dimer interface [polypeptide binding]; other site 1338518005540 metal binding site [ion binding]; metal-binding site 1338518005541 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1338518005542 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1338518005543 Tetramer interface [polypeptide binding]; other site 1338518005544 active site 1338518005545 FMN-binding site [chemical binding]; other site 1338518005546 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1338518005547 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1338518005548 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1338518005549 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1338518005550 active site 1338518005551 multimer interface [polypeptide binding]; other site 1338518005552 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1338518005553 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1338518005554 substrate binding pocket [chemical binding]; other site 1338518005555 chain length determination region; other site 1338518005556 substrate-Mg2+ binding site; other site 1338518005557 catalytic residues [active] 1338518005558 aspartate-rich region 1; other site 1338518005559 active site lid residues [active] 1338518005560 aspartate-rich region 2; other site 1338518005561 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1338518005562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518005563 S-adenosylmethionine binding site [chemical binding]; other site 1338518005564 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1338518005565 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1338518005566 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1338518005567 homodecamer interface [polypeptide binding]; other site 1338518005568 GTP cyclohydrolase I; Provisional; Region: PLN03044 1338518005569 active site 1338518005570 putative catalytic site residues [active] 1338518005571 zinc binding site [ion binding]; other site 1338518005572 GTP-CH-I/GFRP interaction surface; other site 1338518005573 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1338518005574 IHF dimer interface [polypeptide binding]; other site 1338518005575 IHF - DNA interface [nucleotide binding]; other site 1338518005576 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1338518005577 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1338518005578 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1338518005579 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1338518005580 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1338518005581 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1338518005582 GTP-binding protein Der; Reviewed; Region: PRK00093 1338518005583 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1338518005584 G1 box; other site 1338518005585 GTP/Mg2+ binding site [chemical binding]; other site 1338518005586 Switch I region; other site 1338518005587 G2 box; other site 1338518005588 Switch II region; other site 1338518005589 G3 box; other site 1338518005590 G4 box; other site 1338518005591 G5 box; other site 1338518005592 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1338518005593 G1 box; other site 1338518005594 GTP/Mg2+ binding site [chemical binding]; other site 1338518005595 Switch I region; other site 1338518005596 G2 box; other site 1338518005597 G3 box; other site 1338518005598 Switch II region; other site 1338518005599 G4 box; other site 1338518005600 G5 box; other site 1338518005601 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1338518005602 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1338518005603 homotetramer interface [polypeptide binding]; other site 1338518005604 FMN binding site [chemical binding]; other site 1338518005605 homodimer contacts [polypeptide binding]; other site 1338518005606 putative active site [active] 1338518005607 putative substrate binding site [chemical binding]; other site 1338518005608 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1338518005609 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1338518005610 RNA binding site [nucleotide binding]; other site 1338518005611 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1338518005612 RNA binding site [nucleotide binding]; other site 1338518005613 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1338518005614 RNA binding site [nucleotide binding]; other site 1338518005615 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1338518005616 RNA binding site [nucleotide binding]; other site 1338518005617 cytidylate kinase; Provisional; Region: cmk; PRK00023 1338518005618 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1338518005619 CMP-binding site; other site 1338518005620 The sites determining sugar specificity; other site 1338518005621 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1338518005622 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1338518005623 PilZ domain; Region: PilZ; pfam07238 1338518005624 germination protein YpeB; Region: spore_YpeB; TIGR02889 1338518005625 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1338518005626 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1338518005627 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1338518005628 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1338518005629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1338518005630 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1338518005631 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1338518005632 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1338518005633 NAD(P) binding site [chemical binding]; other site 1338518005634 adaptor protein; Provisional; Region: PRK02899 1338518005635 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1338518005636 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1338518005637 putative active site [active] 1338518005638 putative metal binding site [ion binding]; other site 1338518005639 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1338518005640 CAAX protease self-immunity; Region: Abi; pfam02517 1338518005641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1338518005642 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1338518005643 Predicted membrane protein [Function unknown]; Region: COG3601 1338518005644 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1338518005645 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1338518005646 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1338518005647 ligand binding site [chemical binding]; other site 1338518005648 NAD binding site [chemical binding]; other site 1338518005649 dimerization interface [polypeptide binding]; other site 1338518005650 catalytic site [active] 1338518005651 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1338518005652 putative L-serine binding site [chemical binding]; other site 1338518005653 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1338518005654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518005655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518005656 DNA binding residues [nucleotide binding] 1338518005657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1338518005658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518005659 dimerization interface [polypeptide binding]; other site 1338518005660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518005661 putative active site [active] 1338518005662 heme pocket [chemical binding]; other site 1338518005663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518005664 dimer interface [polypeptide binding]; other site 1338518005665 phosphorylation site [posttranslational modification] 1338518005666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518005667 ATP binding site [chemical binding]; other site 1338518005668 Mg2+ binding site [ion binding]; other site 1338518005669 G-X-G motif; other site 1338518005670 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518005671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518005672 active site 1338518005673 phosphorylation site [posttranslational modification] 1338518005674 intermolecular recognition site; other site 1338518005675 dimerization interface [polypeptide binding]; other site 1338518005676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518005677 DNA binding site [nucleotide binding] 1338518005678 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1338518005679 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1338518005680 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1338518005681 ResB-like family; Region: ResB; pfam05140 1338518005682 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1338518005683 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1338518005684 catalytic residues [active] 1338518005685 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1338518005686 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1338518005687 RNA binding surface [nucleotide binding]; other site 1338518005688 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1338518005689 active site 1338518005690 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1338518005691 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1338518005692 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1338518005693 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1338518005694 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1338518005695 segregation and condensation protein B; Region: TIGR00281 1338518005696 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1338518005697 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1338518005698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518005699 Coenzyme A binding pocket [chemical binding]; other site 1338518005700 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1338518005701 homopentamer interface [polypeptide binding]; other site 1338518005702 active site 1338518005703 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1338518005704 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1338518005705 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1338518005706 dimerization interface [polypeptide binding]; other site 1338518005707 active site 1338518005708 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1338518005709 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1338518005710 catalytic motif [active] 1338518005711 Zn binding site [ion binding]; other site 1338518005712 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1338518005713 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1338518005714 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1338518005715 Catalytic site [active] 1338518005716 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1338518005717 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1338518005718 active site 1338518005719 Predicted secreted protein [Function unknown]; Region: COG4086 1338518005720 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1338518005721 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1338518005722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1338518005723 active site 1338518005724 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1338518005725 substrate binding site [chemical binding]; other site 1338518005726 catalytic residues [active] 1338518005727 dimer interface [polypeptide binding]; other site 1338518005728 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1338518005729 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1338518005730 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1338518005731 stage V sporulation protein AD; Validated; Region: PRK08304 1338518005732 stage V sporulation protein AD; Provisional; Region: PRK12404 1338518005733 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1338518005734 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1338518005735 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1338518005736 sporulation sigma factor SigF; Validated; Region: PRK05572 1338518005737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518005738 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1338518005739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518005740 DNA binding residues [nucleotide binding] 1338518005741 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1338518005742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518005743 ATP binding site [chemical binding]; other site 1338518005744 Mg2+ binding site [ion binding]; other site 1338518005745 G-X-G motif; other site 1338518005746 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1338518005747 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1338518005748 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1338518005749 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1338518005750 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1338518005751 phosphopentomutase; Provisional; Region: PRK05362 1338518005752 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1338518005753 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1338518005754 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1338518005755 active site 1338518005756 Int/Topo IB signature motif; other site 1338518005757 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1338518005758 ferric uptake regulator; Provisional; Region: fur; PRK09462 1338518005759 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1338518005760 metal binding site 2 [ion binding]; metal-binding site 1338518005761 putative DNA binding helix; other site 1338518005762 metal binding site 1 [ion binding]; metal-binding site 1338518005763 dimer interface [polypeptide binding]; other site 1338518005764 structural Zn2+ binding site [ion binding]; other site 1338518005765 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1338518005766 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1338518005767 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1338518005768 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1338518005769 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1338518005770 NAD(P) binding pocket [chemical binding]; other site 1338518005771 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1338518005772 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1338518005773 Aspartase; Region: Aspartase; cd01357 1338518005774 active sites [active] 1338518005775 tetramer interface [polypeptide binding]; other site 1338518005776 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1338518005777 active site 1338518005778 homodimer interface [polypeptide binding]; other site 1338518005779 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518005780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518005781 non-specific DNA binding site [nucleotide binding]; other site 1338518005782 salt bridge; other site 1338518005783 sequence-specific DNA binding site [nucleotide binding]; other site 1338518005784 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1338518005785 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1338518005786 dimer interface [polypeptide binding]; other site 1338518005787 ADP-ribose binding site [chemical binding]; other site 1338518005788 active site 1338518005789 nudix motif; other site 1338518005790 metal binding site [ion binding]; metal-binding site 1338518005791 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1338518005792 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1338518005793 active site 1338518005794 catalytic tetrad [active] 1338518005795 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1338518005796 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1338518005797 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1338518005798 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1338518005799 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1338518005800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1338518005801 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1338518005802 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1338518005803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518005804 Coenzyme A binding pocket [chemical binding]; other site 1338518005805 DNA polymerase IV; Reviewed; Region: PRK03103 1338518005806 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1338518005807 active site 1338518005808 DNA binding site [nucleotide binding] 1338518005809 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1338518005810 YolD-like protein; Region: YolD; pfam08863 1338518005811 YqzH-like protein; Region: YqzH; pfam14164 1338518005812 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1338518005813 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1338518005814 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1338518005815 putative dimer interface [polypeptide binding]; other site 1338518005816 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518005817 ligand binding site [chemical binding]; other site 1338518005818 Zn binding site [ion binding]; other site 1338518005819 pantothenate kinase; Provisional; Region: PRK05439 1338518005820 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1338518005821 ATP-binding site [chemical binding]; other site 1338518005822 CoA-binding site [chemical binding]; other site 1338518005823 Mg2+-binding site [ion binding]; other site 1338518005824 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1338518005825 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1338518005826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1338518005827 catalytic residue [active] 1338518005828 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1338518005829 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1338518005830 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1338518005831 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1338518005832 Cytochrome P450; Region: p450; cl12078 1338518005833 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518005834 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1338518005835 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518005836 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518005837 putative NADP binding site [chemical binding]; other site 1338518005838 active site 1338518005839 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518005840 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518005841 active site 1338518005842 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518005843 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518005844 putative NADP binding site [chemical binding]; other site 1338518005845 active site 1338518005846 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518005847 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518005848 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518005849 active site 1338518005850 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518005851 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518005852 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518005853 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518005854 active site 1338518005855 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518005856 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1338518005857 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518005858 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518005859 putative NADP binding site [chemical binding]; other site 1338518005860 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518005861 active site 1338518005862 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1338518005863 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518005864 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518005865 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518005866 active site 1338518005867 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1338518005868 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1338518005869 putative NADP binding site [chemical binding]; other site 1338518005870 active site 1338518005871 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518005872 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1338518005873 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1338518005874 active site 1338518005875 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1338518005876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518005877 NAD(P) binding site [chemical binding]; other site 1338518005878 active site 1338518005879 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1338518005880 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1338518005881 acyl-activating enzyme (AAE) consensus motif; other site 1338518005882 active site 1338518005883 AMP binding site [chemical binding]; other site 1338518005884 CoA binding site [chemical binding]; other site 1338518005885 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1338518005886 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 1338518005887 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1338518005888 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1338518005889 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1338518005890 FMN binding site [chemical binding]; other site 1338518005891 substrate binding site [chemical binding]; other site 1338518005892 putative catalytic residue [active] 1338518005893 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1338518005894 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1338518005895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518005896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518005897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518005898 dimerization interface [polypeptide binding]; other site 1338518005899 GlpM protein; Region: GlpM; cl01212 1338518005900 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1338518005901 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1338518005902 active site 1338518005903 FMN binding site [chemical binding]; other site 1338518005904 substrate binding site [chemical binding]; other site 1338518005905 homotetramer interface [polypeptide binding]; other site 1338518005906 catalytic residue [active] 1338518005907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1338518005908 ribonuclease Z; Region: RNase_Z; TIGR02651 1338518005909 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1338518005910 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1338518005911 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1338518005912 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1338518005913 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1338518005914 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1338518005915 DNA polymerase IV; Validated; Region: PRK01810 1338518005916 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1338518005917 active site 1338518005918 DNA binding site [nucleotide binding] 1338518005919 OxaA-like protein precursor; Validated; Region: PRK01622 1338518005920 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1338518005921 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1338518005922 peptidase T-like protein; Region: PepT-like; TIGR01883 1338518005923 metal binding site [ion binding]; metal-binding site 1338518005924 putative dimer interface [polypeptide binding]; other site 1338518005925 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1338518005926 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1338518005927 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1338518005928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518005929 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1338518005930 dimer interface [polypeptide binding]; other site 1338518005931 substrate binding site [chemical binding]; other site 1338518005932 metal binding site [ion binding]; metal-binding site 1338518005933 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1338518005934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1338518005935 Predicted membrane protein [Function unknown]; Region: COG4129 1338518005936 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1338518005937 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1338518005938 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1338518005939 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1338518005940 Walker A/P-loop; other site 1338518005941 ATP binding site [chemical binding]; other site 1338518005942 Q-loop/lid; other site 1338518005943 ABC transporter signature motif; other site 1338518005944 Walker B; other site 1338518005945 D-loop; other site 1338518005946 H-loop/switch region; other site 1338518005947 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1338518005948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518005949 dimer interface [polypeptide binding]; other site 1338518005950 conserved gate region; other site 1338518005951 putative PBP binding loops; other site 1338518005952 ABC-ATPase subunit interface; other site 1338518005953 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1338518005954 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1338518005955 substrate binding pocket [chemical binding]; other site 1338518005956 membrane-bound complex binding site; other site 1338518005957 hinge residues; other site 1338518005958 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1338518005959 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1338518005960 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1338518005961 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1338518005962 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1338518005963 E3 interaction surface; other site 1338518005964 lipoyl attachment site [posttranslational modification]; other site 1338518005965 e3 binding domain; Region: E3_binding; pfam02817 1338518005966 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1338518005967 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1338518005968 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1338518005969 alpha subunit interface [polypeptide binding]; other site 1338518005970 TPP binding site [chemical binding]; other site 1338518005971 heterodimer interface [polypeptide binding]; other site 1338518005972 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1338518005973 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1338518005974 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1338518005975 tetramer interface [polypeptide binding]; other site 1338518005976 TPP-binding site [chemical binding]; other site 1338518005977 heterodimer interface [polypeptide binding]; other site 1338518005978 phosphorylation loop region [posttranslational modification] 1338518005979 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1338518005980 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1338518005981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518005982 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1338518005983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1338518005984 nucleotide binding site [chemical binding]; other site 1338518005985 Acetokinase family; Region: Acetate_kinase; cl17229 1338518005986 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1338518005987 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1338518005988 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1338518005989 NAD binding site [chemical binding]; other site 1338518005990 Phe binding site; other site 1338518005991 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1338518005992 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1338518005993 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1338518005994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518005995 putative active site [active] 1338518005996 heme pocket [chemical binding]; other site 1338518005997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518005998 putative active site [active] 1338518005999 heme pocket [chemical binding]; other site 1338518006000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518006001 Walker A motif; other site 1338518006002 ATP binding site [chemical binding]; other site 1338518006003 Walker B motif; other site 1338518006004 arginine finger; other site 1338518006005 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1338518006006 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1338518006007 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1338518006008 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1338518006009 tetramer interface [polypeptide binding]; other site 1338518006010 active site 1338518006011 Mg2+/Mn2+ binding site [ion binding]; other site 1338518006012 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1338518006013 dimer interface [polypeptide binding]; other site 1338518006014 Citrate synthase; Region: Citrate_synt; pfam00285 1338518006015 active site 1338518006016 coenzyme A binding site [chemical binding]; other site 1338518006017 citrylCoA binding site [chemical binding]; other site 1338518006018 oxalacetate/citrate binding site [chemical binding]; other site 1338518006019 catalytic triad [active] 1338518006020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1338518006021 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1338518006022 FAD binding site [chemical binding]; other site 1338518006023 homotetramer interface [polypeptide binding]; other site 1338518006024 substrate binding pocket [chemical binding]; other site 1338518006025 catalytic base [active] 1338518006026 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1338518006027 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1338518006028 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1338518006029 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1338518006030 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1338518006031 dimer interface [polypeptide binding]; other site 1338518006032 active site 1338518006033 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1338518006034 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1338518006035 active site 1338518006036 catalytic site [active] 1338518006037 metal binding site [ion binding]; metal-binding site 1338518006038 dimer interface [polypeptide binding]; other site 1338518006039 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1338518006040 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1338518006041 active site 1338518006042 metal binding site [ion binding]; metal-binding site 1338518006043 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1338518006044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518006045 sequence-specific DNA binding site [nucleotide binding]; other site 1338518006046 salt bridge; other site 1338518006047 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1338518006048 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1338518006049 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1338518006050 putative active site [active] 1338518006051 putative FMN binding site [chemical binding]; other site 1338518006052 putative substrate binding site [chemical binding]; other site 1338518006053 putative catalytic residue [active] 1338518006054 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1338518006055 alanine racemase; Region: alr; TIGR00492 1338518006056 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1338518006057 active site 1338518006058 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1338518006059 dimer interface [polypeptide binding]; other site 1338518006060 substrate binding site [chemical binding]; other site 1338518006061 catalytic residues [active] 1338518006062 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1338518006063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518006064 active site 1338518006065 phosphorylation site [posttranslational modification] 1338518006066 intermolecular recognition site; other site 1338518006067 dimerization interface [polypeptide binding]; other site 1338518006068 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1338518006069 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1338518006070 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1338518006071 protein binding site [polypeptide binding]; other site 1338518006072 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1338518006073 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1338518006074 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1338518006075 Walker A/P-loop; other site 1338518006076 ATP binding site [chemical binding]; other site 1338518006077 Q-loop/lid; other site 1338518006078 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1338518006079 ABC transporter signature motif; other site 1338518006080 Walker B; other site 1338518006081 D-loop; other site 1338518006082 H-loop/switch region; other site 1338518006083 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1338518006084 arginine repressor; Provisional; Region: PRK04280 1338518006085 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1338518006086 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1338518006087 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1338518006088 RNA binding surface [nucleotide binding]; other site 1338518006089 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1338518006090 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1338518006091 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1338518006092 TPP-binding site; other site 1338518006093 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1338518006094 PYR/PP interface [polypeptide binding]; other site 1338518006095 dimer interface [polypeptide binding]; other site 1338518006096 TPP binding site [chemical binding]; other site 1338518006097 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1338518006098 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1338518006099 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1338518006100 substrate binding pocket [chemical binding]; other site 1338518006101 chain length determination region; other site 1338518006102 substrate-Mg2+ binding site; other site 1338518006103 catalytic residues [active] 1338518006104 aspartate-rich region 1; other site 1338518006105 active site lid residues [active] 1338518006106 aspartate-rich region 2; other site 1338518006107 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1338518006108 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1338518006109 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1338518006110 generic binding surface II; other site 1338518006111 generic binding surface I; other site 1338518006112 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1338518006113 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1338518006114 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1338518006115 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1338518006116 homodimer interface [polypeptide binding]; other site 1338518006117 NADP binding site [chemical binding]; other site 1338518006118 substrate binding site [chemical binding]; other site 1338518006119 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1338518006120 putative RNA binding site [nucleotide binding]; other site 1338518006121 Asp23 family; Region: Asp23; pfam03780 1338518006122 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1338518006123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1338518006124 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1338518006125 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1338518006126 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1338518006127 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1338518006128 carboxyltransferase (CT) interaction site; other site 1338518006129 biotinylation site [posttranslational modification]; other site 1338518006130 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1338518006131 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1338518006132 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1338518006133 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1338518006134 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1338518006135 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1338518006136 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1338518006137 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1338518006138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518006139 Walker A motif; other site 1338518006140 ATP binding site [chemical binding]; other site 1338518006141 Walker B motif; other site 1338518006142 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1338518006143 elongation factor P; Validated; Region: PRK00529 1338518006144 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1338518006145 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1338518006146 RNA binding site [nucleotide binding]; other site 1338518006147 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1338518006148 RNA binding site [nucleotide binding]; other site 1338518006149 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1338518006150 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1338518006151 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1338518006152 active site 1338518006153 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1338518006154 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1338518006155 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1338518006156 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1338518006157 active site 1338518006158 nucleophile elbow; other site 1338518006159 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1338518006160 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1338518006161 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1338518006162 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1338518006163 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1338518006164 active site residue [active] 1338518006165 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1338518006166 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1338518006167 tetramer interface [polypeptide binding]; other site 1338518006168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518006169 catalytic residue [active] 1338518006170 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1338518006171 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1338518006172 tetramer interface [polypeptide binding]; other site 1338518006173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518006174 catalytic residue [active] 1338518006175 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1338518006176 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1338518006177 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1338518006178 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1338518006179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518006180 ATP binding site [chemical binding]; other site 1338518006181 putative Mg++ binding site [ion binding]; other site 1338518006182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518006183 nucleotide binding region [chemical binding]; other site 1338518006184 ATP-binding site [chemical binding]; other site 1338518006185 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1338518006186 Anti-repressor SinI; Region: SinI; pfam08671 1338518006187 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518006188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518006189 non-specific DNA binding site [nucleotide binding]; other site 1338518006190 salt bridge; other site 1338518006191 sequence-specific DNA binding site [nucleotide binding]; other site 1338518006192 Anti-repressor SinI; Region: SinI; pfam08671 1338518006193 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1338518006194 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1338518006195 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1338518006196 Catalytic site [active] 1338518006197 YqzE-like protein; Region: YqzE; pfam14038 1338518006198 ComG operon protein 7; Region: ComGG; pfam14173 1338518006199 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1338518006200 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1338518006201 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1338518006202 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1338518006203 Type II/IV secretion system protein; Region: T2SE; pfam00437 1338518006204 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1338518006205 Walker A motif; other site 1338518006206 ATP binding site [chemical binding]; other site 1338518006207 Walker B motif; other site 1338518006208 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1338518006209 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1338518006210 Cl binding site [ion binding]; other site 1338518006211 oligomer interface [polypeptide binding]; other site 1338518006212 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1338518006213 Domain of unknown function DUF21; Region: DUF21; pfam01595 1338518006214 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1338518006215 Transporter associated domain; Region: CorC_HlyC; smart01091 1338518006216 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1338518006217 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1338518006218 ArsC family; Region: ArsC; pfam03960 1338518006219 putative catalytic residues [active] 1338518006220 thiol/disulfide switch; other site 1338518006221 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1338518006222 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1338518006223 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1338518006224 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1338518006225 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1338518006226 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1338518006227 putative active site [active] 1338518006228 Zn binding site [ion binding]; other site 1338518006229 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1338518006230 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1338518006231 nucleotide binding site [chemical binding]; other site 1338518006232 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1338518006233 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1338518006234 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1338518006235 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1338518006236 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1338518006237 YceG-like family; Region: YceG; pfam02618 1338518006238 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1338518006239 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1338518006240 Walker A/P-loop; other site 1338518006241 ATP binding site [chemical binding]; other site 1338518006242 Q-loop/lid; other site 1338518006243 ABC transporter signature motif; other site 1338518006244 Walker B; other site 1338518006245 D-loop; other site 1338518006246 H-loop/switch region; other site 1338518006247 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1338518006248 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1338518006249 Walker A/P-loop; other site 1338518006250 ATP binding site [chemical binding]; other site 1338518006251 Q-loop/lid; other site 1338518006252 ABC transporter signature motif; other site 1338518006253 Walker B; other site 1338518006254 D-loop; other site 1338518006255 H-loop/switch region; other site 1338518006256 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1338518006257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518006258 dimer interface [polypeptide binding]; other site 1338518006259 conserved gate region; other site 1338518006260 ABC-ATPase subunit interface; other site 1338518006261 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1338518006262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518006263 dimer interface [polypeptide binding]; other site 1338518006264 conserved gate region; other site 1338518006265 putative PBP binding loops; other site 1338518006266 ABC-ATPase subunit interface; other site 1338518006267 PBP superfamily domain; Region: PBP_like_2; cl17296 1338518006268 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1338518006269 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1338518006270 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1338518006271 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1338518006272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518006274 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1338518006275 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1338518006276 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1338518006277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1338518006278 Lysin motif; Region: LysM; smart00257 1338518006279 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1338518006280 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1338518006281 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1338518006282 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1338518006283 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1338518006284 metal binding site 2 [ion binding]; metal-binding site 1338518006285 putative DNA binding helix; other site 1338518006286 metal binding site 1 [ion binding]; metal-binding site 1338518006287 dimer interface [polypeptide binding]; other site 1338518006288 structural Zn2+ binding site [ion binding]; other site 1338518006289 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1338518006290 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518006291 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1338518006292 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1338518006293 endonuclease IV; Provisional; Region: PRK01060 1338518006294 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1338518006295 AP (apurinic/apyrimidinic) site pocket; other site 1338518006296 DNA interaction; other site 1338518006297 Metal-binding active site; metal-binding site 1338518006298 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1338518006299 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1338518006300 ATP binding site [chemical binding]; other site 1338518006301 Mg++ binding site [ion binding]; other site 1338518006302 motif III; other site 1338518006303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518006304 nucleotide binding region [chemical binding]; other site 1338518006305 ATP-binding site [chemical binding]; other site 1338518006306 YqfQ-like protein; Region: YqfQ; pfam14181 1338518006307 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1338518006308 LytB protein; Region: LYTB; pfam02401 1338518006309 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1338518006310 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1338518006311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1338518006312 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1338518006313 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1338518006314 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1338518006315 Family of unknown function (DUF633); Region: DUF633; pfam04816 1338518006316 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1338518006317 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1338518006318 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1338518006319 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1338518006320 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1338518006321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518006322 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1338518006323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518006324 DNA binding residues [nucleotide binding] 1338518006325 DNA primase; Validated; Region: dnaG; PRK05667 1338518006326 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1338518006327 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1338518006328 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1338518006329 active site 1338518006330 metal binding site [ion binding]; metal-binding site 1338518006331 interdomain interaction site; other site 1338518006332 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1338518006333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1338518006334 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1338518006335 HTH domain; Region: HTH_11; pfam08279 1338518006336 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1338518006337 FOG: CBS domain [General function prediction only]; Region: COG0517 1338518006338 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1338518006339 DALR anticodon binding domain; Region: DALR_1; pfam05746 1338518006340 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1338518006341 dimer interface [polypeptide binding]; other site 1338518006342 motif 1; other site 1338518006343 active site 1338518006344 motif 2; other site 1338518006345 motif 3; other site 1338518006346 Recombination protein O N terminal; Region: RecO_N; pfam11967 1338518006347 DNA repair protein RecO; Region: reco; TIGR00613 1338518006348 Recombination protein O C terminal; Region: RecO_C; pfam02565 1338518006349 YqzL-like protein; Region: YqzL; pfam14006 1338518006350 GTPase Era; Reviewed; Region: era; PRK00089 1338518006351 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1338518006352 G1 box; other site 1338518006353 GTP/Mg2+ binding site [chemical binding]; other site 1338518006354 Switch I region; other site 1338518006355 G2 box; other site 1338518006356 Switch II region; other site 1338518006357 G3 box; other site 1338518006358 G4 box; other site 1338518006359 G5 box; other site 1338518006360 KH domain; Region: KH_2; pfam07650 1338518006361 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1338518006362 active site 1338518006363 catalytic motif [active] 1338518006364 Zn binding site [ion binding]; other site 1338518006365 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1338518006366 metal-binding heat shock protein; Provisional; Region: PRK00016 1338518006367 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1338518006368 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1338518006369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518006370 Zn2+ binding site [ion binding]; other site 1338518006371 Mg2+ binding site [ion binding]; other site 1338518006372 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1338518006373 PhoH-like protein; Region: PhoH; pfam02562 1338518006374 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1338518006375 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1338518006376 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1338518006377 hypothetical protein; Provisional; Region: PRK13665 1338518006378 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1338518006379 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1338518006380 dimer interface [polypeptide binding]; other site 1338518006381 active site residues [active] 1338518006382 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1338518006383 Yqey-like protein; Region: YqeY; pfam09424 1338518006384 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1338518006385 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1338518006386 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1338518006387 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1338518006388 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1338518006389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518006390 FeS/SAM binding site; other site 1338518006391 TRAM domain; Region: TRAM; cl01282 1338518006392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1338518006393 RNA methyltransferase, RsmE family; Region: TIGR00046 1338518006394 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1338518006395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518006396 S-adenosylmethionine binding site [chemical binding]; other site 1338518006397 chaperone protein DnaJ; Provisional; Region: PRK14280 1338518006398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1338518006399 HSP70 interaction site [polypeptide binding]; other site 1338518006400 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1338518006401 substrate binding site [polypeptide binding]; other site 1338518006402 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1338518006403 Zn binding sites [ion binding]; other site 1338518006404 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1338518006405 dimer interface [polypeptide binding]; other site 1338518006406 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1338518006407 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1338518006408 nucleotide binding site [chemical binding]; other site 1338518006409 NEF interaction site [polypeptide binding]; other site 1338518006410 SBD interface [polypeptide binding]; other site 1338518006411 GrpE; Region: GrpE; pfam01025 1338518006412 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1338518006413 dimer interface [polypeptide binding]; other site 1338518006414 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1338518006415 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1338518006416 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1338518006417 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1338518006418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518006419 FeS/SAM binding site; other site 1338518006420 HemN C-terminal domain; Region: HemN_C; pfam06969 1338518006421 GTP-binding protein LepA; Provisional; Region: PRK05433 1338518006422 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1338518006423 G1 box; other site 1338518006424 putative GEF interaction site [polypeptide binding]; other site 1338518006425 GTP/Mg2+ binding site [chemical binding]; other site 1338518006426 Switch I region; other site 1338518006427 G2 box; other site 1338518006428 G3 box; other site 1338518006429 Switch II region; other site 1338518006430 G4 box; other site 1338518006431 G5 box; other site 1338518006432 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1338518006433 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1338518006434 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1338518006435 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1338518006436 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1338518006437 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1338518006438 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1338518006439 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1338518006440 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1338518006441 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1338518006442 Competence protein; Region: Competence; pfam03772 1338518006443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1338518006444 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1338518006445 catalytic motif [active] 1338518006446 Zn binding site [ion binding]; other site 1338518006447 SLBB domain; Region: SLBB; pfam10531 1338518006448 comEA protein; Region: comE; TIGR01259 1338518006449 Helix-hairpin-helix motif; Region: HHH; pfam00633 1338518006450 late competence protein ComER; Validated; Region: PRK07680 1338518006451 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1338518006452 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1338518006453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518006454 S-adenosylmethionine binding site [chemical binding]; other site 1338518006455 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1338518006456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518006457 Zn2+ binding site [ion binding]; other site 1338518006458 Mg2+ binding site [ion binding]; other site 1338518006459 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1338518006460 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1338518006461 active site 1338518006462 (T/H)XGH motif; other site 1338518006463 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1338518006464 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1338518006465 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1338518006466 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1338518006467 shikimate binding site; other site 1338518006468 NAD(P) binding site [chemical binding]; other site 1338518006469 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1338518006470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518006471 active site 1338518006472 motif I; other site 1338518006473 motif II; other site 1338518006474 Sporulation inhibitor A; Region: Sda; pfam08970 1338518006475 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1338518006476 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1338518006477 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1338518006478 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1338518006479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1338518006480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518006481 H+ Antiporter protein; Region: 2A0121; TIGR00900 1338518006482 putative substrate translocation pore; other site 1338518006483 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1338518006484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1338518006485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518006486 DNA binding residues [nucleotide binding] 1338518006487 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1338518006488 Predicted transcriptional regulators [Transcription]; Region: COG1695 1338518006489 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1338518006490 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1338518006491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518006492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1338518006493 hypothetical protein; Validated; Region: PRK06217 1338518006494 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1338518006495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518006496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518006497 putative substrate translocation pore; other site 1338518006498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518006499 DinB family; Region: DinB; pfam05163 1338518006500 DinB superfamily; Region: DinB_2; pfam12867 1338518006501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1338518006502 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1338518006503 active site 1338518006504 motif I; other site 1338518006505 motif II; other site 1338518006506 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1338518006507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518006508 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1338518006509 active site 1338518006510 motif I; other site 1338518006511 motif II; other site 1338518006512 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1338518006513 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1338518006514 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1338518006515 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1338518006516 putative active site [active] 1338518006517 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1338518006518 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1338518006519 active site 1338518006520 P-loop; other site 1338518006521 phosphorylation site [posttranslational modification] 1338518006522 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1338518006523 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1338518006524 active site 1338518006525 phosphorylation site [posttranslational modification] 1338518006526 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1338518006527 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1338518006528 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1338518006529 putative deacylase active site [active] 1338518006530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518006531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518006532 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1338518006533 putative dimerization interface [polypeptide binding]; other site 1338518006534 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1338518006535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518006536 putative substrate translocation pore; other site 1338518006537 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1338518006538 Cytochrome P450; Region: p450; pfam00067 1338518006539 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1338518006540 Flavodoxin; Region: Flavodoxin_1; pfam00258 1338518006541 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1338518006542 FAD binding pocket [chemical binding]; other site 1338518006543 FAD binding motif [chemical binding]; other site 1338518006544 catalytic residues [active] 1338518006545 NAD binding pocket [chemical binding]; other site 1338518006546 phosphate binding motif [ion binding]; other site 1338518006547 beta-alpha-beta structure motif; other site 1338518006548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518006549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518006550 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1338518006551 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1338518006552 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1338518006553 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1338518006554 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1338518006555 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1338518006556 catalytic loop [active] 1338518006557 iron binding site [ion binding]; other site 1338518006558 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1338518006559 4Fe-4S binding domain; Region: Fer4; pfam00037 1338518006560 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1338518006561 [4Fe-4S] binding site [ion binding]; other site 1338518006562 molybdopterin cofactor binding site; other site 1338518006563 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1338518006564 molybdopterin cofactor binding site; other site 1338518006565 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1338518006566 YrhC-like protein; Region: YrhC; pfam14143 1338518006567 cystathionine beta-lyase; Provisional; Region: PRK07671 1338518006568 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1338518006569 homodimer interface [polypeptide binding]; other site 1338518006570 substrate-cofactor binding pocket; other site 1338518006571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518006572 catalytic residue [active] 1338518006573 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1338518006574 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1338518006575 dimer interface [polypeptide binding]; other site 1338518006576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518006577 catalytic residue [active] 1338518006578 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1338518006579 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1338518006580 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1338518006581 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1338518006582 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1338518006583 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1338518006584 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1338518006585 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1338518006586 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1338518006587 ATP-binding site [chemical binding]; other site 1338518006588 Sugar specificity; other site 1338518006589 Pyrimidine base specificity; other site 1338518006590 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1338518006591 Peptidase family U32; Region: Peptidase_U32; pfam01136 1338518006592 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1338518006593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518006594 S-adenosylmethionine binding site [chemical binding]; other site 1338518006595 conserved hypothetical protein, YceG family; Region: TIGR00247 1338518006596 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1338518006597 dimerization interface [polypeptide binding]; other site 1338518006598 hypothetical protein; Provisional; Region: PRK13678 1338518006599 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1338518006600 hypothetical protein; Provisional; Region: PRK05473 1338518006601 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1338518006602 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1338518006603 motif 1; other site 1338518006604 active site 1338518006605 motif 2; other site 1338518006606 motif 3; other site 1338518006607 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1338518006608 DHHA1 domain; Region: DHHA1; pfam02272 1338518006609 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1338518006610 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1338518006611 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1338518006612 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1338518006613 Walker A/P-loop; other site 1338518006614 ATP binding site [chemical binding]; other site 1338518006615 Q-loop/lid; other site 1338518006616 ABC transporter signature motif; other site 1338518006617 Walker B; other site 1338518006618 D-loop; other site 1338518006619 H-loop/switch region; other site 1338518006620 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1338518006621 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1338518006622 substrate binding pocket [chemical binding]; other site 1338518006623 membrane-bound complex binding site; other site 1338518006624 hinge residues; other site 1338518006625 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1338518006626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518006627 dimer interface [polypeptide binding]; other site 1338518006628 conserved gate region; other site 1338518006629 putative PBP binding loops; other site 1338518006630 ABC-ATPase subunit interface; other site 1338518006631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518006632 dimer interface [polypeptide binding]; other site 1338518006633 conserved gate region; other site 1338518006634 putative PBP binding loops; other site 1338518006635 ABC-ATPase subunit interface; other site 1338518006636 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1338518006637 PRC-barrel domain; Region: PRC; pfam05239 1338518006638 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1338518006639 AAA domain; Region: AAA_30; pfam13604 1338518006640 Family description; Region: UvrD_C_2; pfam13538 1338518006641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518006642 binding surface 1338518006643 TPR repeat; Region: TPR_11; pfam13414 1338518006644 TPR motif; other site 1338518006645 TPR repeat; Region: TPR_11; pfam13414 1338518006646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518006647 binding surface 1338518006648 TPR motif; other site 1338518006649 TPR repeat; Region: TPR_11; pfam13414 1338518006650 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1338518006651 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1338518006652 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1338518006653 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1338518006654 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1338518006655 catalytic residue [active] 1338518006656 Predicted transcriptional regulator [Transcription]; Region: COG1959 1338518006657 Transcriptional regulator; Region: Rrf2; pfam02082 1338518006658 recombination factor protein RarA; Reviewed; Region: PRK13342 1338518006659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518006660 Walker A motif; other site 1338518006661 ATP binding site [chemical binding]; other site 1338518006662 Walker B motif; other site 1338518006663 arginine finger; other site 1338518006664 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1338518006665 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1338518006666 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1338518006667 putative ATP binding site [chemical binding]; other site 1338518006668 putative substrate interface [chemical binding]; other site 1338518006669 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1338518006670 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1338518006671 dimer interface [polypeptide binding]; other site 1338518006672 anticodon binding site; other site 1338518006673 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1338518006674 homodimer interface [polypeptide binding]; other site 1338518006675 motif 1; other site 1338518006676 active site 1338518006677 motif 2; other site 1338518006678 GAD domain; Region: GAD; pfam02938 1338518006679 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1338518006680 active site 1338518006681 motif 3; other site 1338518006682 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1338518006683 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1338518006684 dimer interface [polypeptide binding]; other site 1338518006685 motif 1; other site 1338518006686 active site 1338518006687 motif 2; other site 1338518006688 motif 3; other site 1338518006689 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1338518006690 anticodon binding site; other site 1338518006691 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1338518006692 putative active site [active] 1338518006693 dimerization interface [polypeptide binding]; other site 1338518006694 putative tRNAtyr binding site [nucleotide binding]; other site 1338518006695 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1338518006696 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518006697 Zn2+ binding site [ion binding]; other site 1338518006698 Mg2+ binding site [ion binding]; other site 1338518006699 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1338518006700 synthetase active site [active] 1338518006701 NTP binding site [chemical binding]; other site 1338518006702 metal binding site [ion binding]; metal-binding site 1338518006703 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1338518006704 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1338518006705 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1338518006706 active site 1338518006707 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1338518006708 DHH family; Region: DHH; pfam01368 1338518006709 DHHA1 domain; Region: DHHA1; pfam02272 1338518006710 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1338518006711 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1338518006712 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1338518006713 TrkA-C domain; Region: TrkA_C; pfam02080 1338518006714 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1338518006715 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1338518006716 Protein export membrane protein; Region: SecD_SecF; pfam02355 1338518006717 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1338518006718 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1338518006719 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1338518006720 Predicted membrane protein [Function unknown]; Region: COG2323 1338518006721 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1338518006722 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1338518006723 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1338518006724 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1338518006725 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1338518006726 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1338518006727 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1338518006728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518006729 Walker A motif; other site 1338518006730 ATP binding site [chemical binding]; other site 1338518006731 Walker B motif; other site 1338518006732 arginine finger; other site 1338518006733 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1338518006734 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1338518006735 RuvA N terminal domain; Region: RuvA_N; pfam01330 1338518006736 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1338518006737 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1338518006738 BofC C-terminal domain; Region: BofC_C; pfam08955 1338518006739 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1338518006740 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1338518006741 quinolinate synthetase; Provisional; Region: PRK09375 1338518006742 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1338518006743 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1338518006744 dimerization interface [polypeptide binding]; other site 1338518006745 active site 1338518006746 L-aspartate oxidase; Provisional; Region: PRK08071 1338518006747 L-aspartate oxidase; Provisional; Region: PRK06175 1338518006748 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1338518006749 cysteine desulfurase; Provisional; Region: PRK02948 1338518006750 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1338518006751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1338518006752 catalytic residue [active] 1338518006753 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1338518006754 HTH domain; Region: HTH_11; pfam08279 1338518006755 3H domain; Region: 3H; pfam02829 1338518006756 prephenate dehydratase; Provisional; Region: PRK11898 1338518006757 Prephenate dehydratase; Region: PDT; pfam00800 1338518006758 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1338518006759 putative L-Phe binding site [chemical binding]; other site 1338518006760 hypothetical protein; Provisional; Region: PRK04435 1338518006761 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1338518006762 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1338518006763 GTP1/OBG; Region: GTP1_OBG; pfam01018 1338518006764 Obg GTPase; Region: Obg; cd01898 1338518006765 G1 box; other site 1338518006766 GTP/Mg2+ binding site [chemical binding]; other site 1338518006767 Switch I region; other site 1338518006768 G2 box; other site 1338518006769 G3 box; other site 1338518006770 Switch II region; other site 1338518006771 G4 box; other site 1338518006772 G5 box; other site 1338518006773 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1338518006774 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1338518006775 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1338518006776 hypothetical protein; Provisional; Region: PRK14553 1338518006777 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1338518006778 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1338518006779 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1338518006780 Peptidase family M50; Region: Peptidase_M50; pfam02163 1338518006781 active site 1338518006782 putative substrate binding region [chemical binding]; other site 1338518006783 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1338518006784 Peptidase family M23; Region: Peptidase_M23; pfam01551 1338518006785 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1338518006786 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1338518006787 Switch I; other site 1338518006788 Switch II; other site 1338518006789 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1338518006790 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1338518006791 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1338518006792 rod shape-determining protein MreC; Region: mreC; TIGR00219 1338518006793 rod shape-determining protein MreC; Region: MreC; pfam04085 1338518006794 rod shape-determining protein MreB; Provisional; Region: PRK13927 1338518006795 MreB and similar proteins; Region: MreB_like; cd10225 1338518006796 nucleotide binding site [chemical binding]; other site 1338518006797 Mg binding site [ion binding]; other site 1338518006798 putative protofilament interaction site [polypeptide binding]; other site 1338518006799 RodZ interaction site [polypeptide binding]; other site 1338518006800 hypothetical protein; Reviewed; Region: PRK00024 1338518006801 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1338518006802 MPN+ (JAMM) motif; other site 1338518006803 Zinc-binding site [ion binding]; other site 1338518006804 Maf-like protein; Region: Maf; pfam02545 1338518006805 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1338518006806 active site 1338518006807 dimer interface [polypeptide binding]; other site 1338518006808 Sporulation related domain; Region: SPOR; pfam05036 1338518006809 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1338518006810 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1338518006811 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1338518006812 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1338518006813 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1338518006814 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1338518006815 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1338518006816 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1338518006817 active site 1338518006818 HIGH motif; other site 1338518006819 nucleotide binding site [chemical binding]; other site 1338518006820 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1338518006821 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1338518006822 active site 1338518006823 KMSKS motif; other site 1338518006824 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1338518006825 tRNA binding surface [nucleotide binding]; other site 1338518006826 anticodon binding site; other site 1338518006827 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1338518006828 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1338518006829 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518006830 inhibitor-cofactor binding pocket; inhibition site 1338518006831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518006832 catalytic residue [active] 1338518006833 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1338518006834 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1338518006835 active site 1338518006836 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1338518006837 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1338518006838 domain interfaces; other site 1338518006839 active site 1338518006840 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1338518006841 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1338518006842 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1338518006843 tRNA; other site 1338518006844 putative tRNA binding site [nucleotide binding]; other site 1338518006845 putative NADP binding site [chemical binding]; other site 1338518006846 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1338518006847 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1338518006848 G1 box; other site 1338518006849 GTP/Mg2+ binding site [chemical binding]; other site 1338518006850 Switch I region; other site 1338518006851 G2 box; other site 1338518006852 G3 box; other site 1338518006853 Switch II region; other site 1338518006854 G4 box; other site 1338518006855 G5 box; other site 1338518006856 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1338518006857 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1338518006858 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1338518006859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518006860 Walker A motif; other site 1338518006861 ATP binding site [chemical binding]; other site 1338518006862 Walker B motif; other site 1338518006863 arginine finger; other site 1338518006864 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1338518006865 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1338518006866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518006867 Walker A motif; other site 1338518006868 ATP binding site [chemical binding]; other site 1338518006869 Walker B motif; other site 1338518006870 arginine finger; other site 1338518006871 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1338518006872 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1338518006873 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1338518006874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518006875 Walker A motif; other site 1338518006876 ATP binding site [chemical binding]; other site 1338518006877 Walker B motif; other site 1338518006878 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1338518006879 trigger factor; Provisional; Region: tig; PRK01490 1338518006880 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1338518006881 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1338518006882 TPR repeat; Region: TPR_11; pfam13414 1338518006883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518006884 binding surface 1338518006885 TPR motif; other site 1338518006886 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1338518006887 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1338518006888 substrate binding site [chemical binding]; other site 1338518006889 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1338518006890 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1338518006891 substrate binding site [chemical binding]; other site 1338518006892 ligand binding site [chemical binding]; other site 1338518006893 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1338518006894 tartrate dehydrogenase; Region: TTC; TIGR02089 1338518006895 2-isopropylmalate synthase; Validated; Region: PRK00915 1338518006896 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1338518006897 active site 1338518006898 catalytic residues [active] 1338518006899 metal binding site [ion binding]; metal-binding site 1338518006900 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1338518006901 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1338518006902 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1338518006903 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1338518006904 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1338518006905 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1338518006906 putative valine binding site [chemical binding]; other site 1338518006907 dimer interface [polypeptide binding]; other site 1338518006908 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1338518006909 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1338518006910 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1338518006911 PYR/PP interface [polypeptide binding]; other site 1338518006912 dimer interface [polypeptide binding]; other site 1338518006913 TPP binding site [chemical binding]; other site 1338518006914 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1338518006915 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1338518006916 TPP-binding site [chemical binding]; other site 1338518006917 dimer interface [polypeptide binding]; other site 1338518006918 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1338518006919 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1338518006920 active site 1338518006921 metal binding site [ion binding]; metal-binding site 1338518006922 homotetramer interface [polypeptide binding]; other site 1338518006923 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1338518006924 active site 1338518006925 dimerization interface [polypeptide binding]; other site 1338518006926 ribonuclease PH; Reviewed; Region: rph; PRK00173 1338518006927 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1338518006928 hexamer interface [polypeptide binding]; other site 1338518006929 active site 1338518006930 Sporulation and spore germination; Region: Germane; pfam10646 1338518006931 Spore germination protein [General function prediction only]; Region: COG5401 1338518006932 Sporulation and spore germination; Region: Germane; pfam10646 1338518006933 glutamate racemase; Provisional; Region: PRK00865 1338518006934 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518006935 MarR family; Region: MarR; pfam01047 1338518006936 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518006937 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518006938 DNA binding residues [nucleotide binding] 1338518006939 dimerization interface [polypeptide binding]; other site 1338518006940 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1338518006941 active site 1338518006942 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1338518006943 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1338518006944 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1338518006945 L-aspartate oxidase; Provisional; Region: PRK06175 1338518006946 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1338518006947 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1338518006948 putative Iron-sulfur protein interface [polypeptide binding]; other site 1338518006949 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1338518006950 proximal heme binding site [chemical binding]; other site 1338518006951 distal heme binding site [chemical binding]; other site 1338518006952 putative dimer interface [polypeptide binding]; other site 1338518006953 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1338518006954 aspartate kinase; Reviewed; Region: PRK06635 1338518006955 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1338518006956 putative nucleotide binding site [chemical binding]; other site 1338518006957 putative catalytic residues [active] 1338518006958 putative Mg ion binding site [ion binding]; other site 1338518006959 putative aspartate binding site [chemical binding]; other site 1338518006960 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1338518006961 putative allosteric regulatory site; other site 1338518006962 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1338518006963 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1338518006964 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1338518006965 GIY-YIG motif/motif A; other site 1338518006966 active site 1338518006967 catalytic site [active] 1338518006968 putative DNA binding site [nucleotide binding]; other site 1338518006969 metal binding site [ion binding]; metal-binding site 1338518006970 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1338518006971 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1338518006972 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1338518006973 catalytic residues [active] 1338518006974 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1338518006975 Ligand binding site [chemical binding]; other site 1338518006976 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1338518006977 enoyl-CoA hydratase; Provisional; Region: PRK07658 1338518006978 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1338518006979 substrate binding site [chemical binding]; other site 1338518006980 oxyanion hole (OAH) forming residues; other site 1338518006981 trimer interface [polypeptide binding]; other site 1338518006982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518006983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518006984 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1338518006985 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1338518006986 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1338518006987 acyl-activating enzyme (AAE) consensus motif; other site 1338518006988 putative AMP binding site [chemical binding]; other site 1338518006989 putative active site [active] 1338518006990 putative CoA binding site [chemical binding]; other site 1338518006991 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1338518006992 Predicted membrane protein [Function unknown]; Region: COG3766 1338518006993 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1338518006994 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1338518006995 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1338518006996 MutS domain III; Region: MutS_III; pfam05192 1338518006997 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1338518006998 Walker A/P-loop; other site 1338518006999 ATP binding site [chemical binding]; other site 1338518007000 Q-loop/lid; other site 1338518007001 ABC transporter signature motif; other site 1338518007002 Walker B; other site 1338518007003 D-loop; other site 1338518007004 H-loop/switch region; other site 1338518007005 Smr domain; Region: Smr; pfam01713 1338518007006 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1338518007007 Colicin V production protein; Region: Colicin_V; pfam02674 1338518007008 cell division protein ZapA; Provisional; Region: PRK14126 1338518007009 ribonuclease HIII; Provisional; Region: PRK00996 1338518007010 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1338518007011 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1338518007012 RNA/DNA hybrid binding site [nucleotide binding]; other site 1338518007013 active site 1338518007014 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1338518007015 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1338518007016 putative tRNA-binding site [nucleotide binding]; other site 1338518007017 B3/4 domain; Region: B3_4; pfam03483 1338518007018 tRNA synthetase B5 domain; Region: B5; smart00874 1338518007019 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1338518007020 dimer interface [polypeptide binding]; other site 1338518007021 motif 1; other site 1338518007022 motif 3; other site 1338518007023 motif 2; other site 1338518007024 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1338518007025 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1338518007026 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1338518007027 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1338518007028 dimer interface [polypeptide binding]; other site 1338518007029 motif 1; other site 1338518007030 active site 1338518007031 motif 2; other site 1338518007032 motif 3; other site 1338518007033 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1338518007034 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1338518007035 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1338518007036 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1338518007037 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1338518007038 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1338518007039 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1338518007040 FAD binding domain; Region: FAD_binding_4; pfam01565 1338518007041 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1338518007042 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1338518007043 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1338518007044 Cysteine-rich domain; Region: CCG; pfam02754 1338518007045 Cysteine-rich domain; Region: CCG; pfam02754 1338518007046 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1338518007047 Carbon starvation protein CstA; Region: CstA; pfam02554 1338518007048 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1338518007049 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1338518007050 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1338518007051 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1338518007052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518007053 putative PBP binding loops; other site 1338518007054 dimer interface [polypeptide binding]; other site 1338518007055 ABC-ATPase subunit interface; other site 1338518007056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518007057 dimer interface [polypeptide binding]; other site 1338518007058 conserved gate region; other site 1338518007059 putative PBP binding loops; other site 1338518007060 ABC-ATPase subunit interface; other site 1338518007061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1338518007062 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1338518007063 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1338518007064 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1338518007065 active site 1338518007066 metal binding site [ion binding]; metal-binding site 1338518007067 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1338518007068 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1338518007069 intersubunit interface [polypeptide binding]; other site 1338518007070 active site 1338518007071 Zn2+ binding site [ion binding]; other site 1338518007072 ribulokinase; Provisional; Region: PRK04123 1338518007073 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1338518007074 N- and C-terminal domain interface [polypeptide binding]; other site 1338518007075 active site 1338518007076 MgATP binding site [chemical binding]; other site 1338518007077 catalytic site [active] 1338518007078 metal binding site [ion binding]; metal-binding site 1338518007079 carbohydrate binding site [chemical binding]; other site 1338518007080 homodimer interface [polypeptide binding]; other site 1338518007081 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1338518007082 substrate binding site [chemical binding]; other site 1338518007083 active site 1338518007084 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1338518007085 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1338518007086 oligomer interface [polypeptide binding]; other site 1338518007087 active site 1338518007088 metal binding site [ion binding]; metal-binding site 1338518007089 Predicted membrane protein [Function unknown]; Region: COG3326 1338518007090 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1338518007091 23S rRNA binding site [nucleotide binding]; other site 1338518007092 L21 binding site [polypeptide binding]; other site 1338518007093 L13 binding site [polypeptide binding]; other site 1338518007094 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1338518007095 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1338518007096 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1338518007097 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1338518007098 antiholin-like protein LrgB; Provisional; Region: PRK04288 1338518007099 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1338518007100 two-component response regulator; Provisional; Region: PRK14084 1338518007101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518007102 active site 1338518007103 phosphorylation site [posttranslational modification] 1338518007104 intermolecular recognition site; other site 1338518007105 dimerization interface [polypeptide binding]; other site 1338518007106 LytTr DNA-binding domain; Region: LytTR; smart00850 1338518007107 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1338518007108 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1338518007109 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1338518007110 Histidine kinase; Region: His_kinase; pfam06580 1338518007111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518007112 ATP binding site [chemical binding]; other site 1338518007113 Mg2+ binding site [ion binding]; other site 1338518007114 G-X-G motif; other site 1338518007115 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1338518007116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518007117 motif II; other site 1338518007118 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1338518007119 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1338518007120 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1338518007121 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1338518007122 active site 1338518007123 dimer interface [polypeptide binding]; other site 1338518007124 motif 1; other site 1338518007125 motif 2; other site 1338518007126 motif 3; other site 1338518007127 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1338518007128 anticodon binding site; other site 1338518007129 YtxC-like family; Region: YtxC; pfam08812 1338518007130 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1338518007131 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1338518007132 primosomal protein DnaI; Reviewed; Region: PRK08939 1338518007133 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1338518007134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1338518007135 Walker A motif; other site 1338518007136 ATP binding site [chemical binding]; other site 1338518007137 Walker B motif; other site 1338518007138 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1338518007139 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1338518007140 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1338518007141 ATP cone domain; Region: ATP-cone; pfam03477 1338518007142 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1338518007143 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1338518007144 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1338518007145 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1338518007146 Predicted transcriptional regulators [Transcription]; Region: COG1733 1338518007147 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1338518007148 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1338518007149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518007150 putative substrate translocation pore; other site 1338518007151 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1338518007152 active site 1338518007153 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1338518007154 catalytic tetrad [active] 1338518007155 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1338518007156 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1338518007157 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1338518007158 DNA binding site [nucleotide binding] 1338518007159 catalytic residue [active] 1338518007160 H2TH interface [polypeptide binding]; other site 1338518007161 putative catalytic residues [active] 1338518007162 turnover-facilitating residue; other site 1338518007163 intercalation triad [nucleotide binding]; other site 1338518007164 8OG recognition residue [nucleotide binding]; other site 1338518007165 putative reading head residues; other site 1338518007166 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1338518007167 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1338518007168 DNA polymerase I; Provisional; Region: PRK05755 1338518007169 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1338518007170 active site 1338518007171 metal binding site 1 [ion binding]; metal-binding site 1338518007172 putative 5' ssDNA interaction site; other site 1338518007173 metal binding site 3; metal-binding site 1338518007174 metal binding site 2 [ion binding]; metal-binding site 1338518007175 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1338518007176 putative DNA binding site [nucleotide binding]; other site 1338518007177 putative metal binding site [ion binding]; other site 1338518007178 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1338518007179 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1338518007180 active site 1338518007181 DNA binding site [nucleotide binding] 1338518007182 catalytic site [active] 1338518007183 malate dehydrogenase; Reviewed; Region: PRK06223 1338518007184 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1338518007185 NAD(P) binding site [chemical binding]; other site 1338518007186 dimer interface [polypeptide binding]; other site 1338518007187 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1338518007188 substrate binding site [chemical binding]; other site 1338518007189 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1338518007190 isocitrate dehydrogenase; Validated; Region: PRK07362 1338518007191 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1338518007192 dimer interface [polypeptide binding]; other site 1338518007193 Citrate synthase; Region: Citrate_synt; pfam00285 1338518007194 active site 1338518007195 citrylCoA binding site [chemical binding]; other site 1338518007196 oxalacetate/citrate binding site [chemical binding]; other site 1338518007197 coenzyme A binding site [chemical binding]; other site 1338518007198 catalytic triad [active] 1338518007199 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1338518007200 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1338518007201 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1338518007202 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1338518007203 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1338518007204 pyruvate kinase; Provisional; Region: PRK06354 1338518007205 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1338518007206 domain interfaces; other site 1338518007207 active site 1338518007208 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1338518007209 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1338518007210 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1338518007211 active site 1338518007212 ADP/pyrophosphate binding site [chemical binding]; other site 1338518007213 dimerization interface [polypeptide binding]; other site 1338518007214 allosteric effector site; other site 1338518007215 fructose-1,6-bisphosphate binding site; other site 1338518007216 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1338518007217 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1338518007218 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1338518007219 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1338518007220 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1338518007221 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1338518007222 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1338518007223 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1338518007224 putative NAD(P) binding site [chemical binding]; other site 1338518007225 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1338518007226 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1338518007227 active site 1338518007228 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1338518007229 generic binding surface I; other site 1338518007230 generic binding surface II; other site 1338518007231 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1338518007232 YtpI-like protein; Region: YtpI; pfam14007 1338518007233 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1338518007234 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518007235 DNA-binding site [nucleotide binding]; DNA binding site 1338518007236 DRTGG domain; Region: DRTGG; pfam07085 1338518007237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1338518007238 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1338518007239 active site 2 [active] 1338518007240 active site 1 [active] 1338518007241 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1338518007242 metal-dependent hydrolase; Provisional; Region: PRK00685 1338518007243 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1338518007244 classical (c) SDRs; Region: SDR_c; cd05233 1338518007245 NAD(P) binding site [chemical binding]; other site 1338518007246 active site 1338518007247 argininosuccinate lyase; Provisional; Region: PRK00855 1338518007248 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1338518007249 active sites [active] 1338518007250 tetramer interface [polypeptide binding]; other site 1338518007251 argininosuccinate synthase; Provisional; Region: PRK13820 1338518007252 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1338518007253 ANP binding site [chemical binding]; other site 1338518007254 Substrate Binding Site II [chemical binding]; other site 1338518007255 Substrate Binding Site I [chemical binding]; other site 1338518007256 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1338518007257 MPT binding site; other site 1338518007258 trimer interface [polypeptide binding]; other site 1338518007259 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1338518007260 propionate/acetate kinase; Provisional; Region: PRK12379 1338518007261 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1338518007262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518007263 S-adenosylmethionine binding site [chemical binding]; other site 1338518007264 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1338518007265 dimer interface [polypeptide binding]; other site 1338518007266 catalytic triad [active] 1338518007267 peroxidatic and resolving cysteines [active] 1338518007268 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1338518007269 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1338518007270 RDD family; Region: RDD; pfam06271 1338518007271 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1338518007272 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1338518007273 active site 1338518007274 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1338518007275 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1338518007276 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1338518007277 active site 1338518007278 acyl-activating enzyme (AAE) consensus motif; other site 1338518007279 putative CoA binding site [chemical binding]; other site 1338518007280 AMP binding site [chemical binding]; other site 1338518007281 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1338518007282 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1338518007283 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1338518007284 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1338518007285 Ligand Binding Site [chemical binding]; other site 1338518007286 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1338518007287 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1338518007288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1338518007289 catalytic residue [active] 1338518007290 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1338518007291 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1338518007292 TMPIT-like protein; Region: TMPIT; pfam07851 1338518007293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518007294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518007295 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1338518007296 GAF domain; Region: GAF_2; pfam13185 1338518007297 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1338518007298 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1338518007299 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1338518007300 RNA binding surface [nucleotide binding]; other site 1338518007301 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1338518007302 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1338518007303 NAD(P) binding site [chemical binding]; other site 1338518007304 catalytic residues [active] 1338518007305 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1338518007306 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1338518007307 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1338518007308 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1338518007309 heme-binding site [chemical binding]; other site 1338518007310 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1338518007311 FAD binding pocket [chemical binding]; other site 1338518007312 FAD binding motif [chemical binding]; other site 1338518007313 phosphate binding motif [ion binding]; other site 1338518007314 beta-alpha-beta structure motif; other site 1338518007315 NAD binding pocket [chemical binding]; other site 1338518007316 Heme binding pocket [chemical binding]; other site 1338518007317 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1338518007318 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1338518007319 proposed catalytic triad [active] 1338518007320 conserved cys residue [active] 1338518007321 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1338518007322 active site 1338518007323 catalytic triad [active] 1338518007324 oxyanion hole [active] 1338518007325 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1338518007326 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1338518007327 Predicted transcriptional regulators [Transcription]; Region: COG1378 1338518007328 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1338518007329 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1338518007330 C-terminal domain interface [polypeptide binding]; other site 1338518007331 sugar binding site [chemical binding]; other site 1338518007332 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1338518007333 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1338518007334 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1338518007335 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1338518007336 active site 1338518007337 HIGH motif; other site 1338518007338 dimer interface [polypeptide binding]; other site 1338518007339 KMSKS motif; other site 1338518007340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1338518007341 RNA binding surface [nucleotide binding]; other site 1338518007342 acetyl-CoA synthetase; Provisional; Region: PRK04319 1338518007343 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1338518007344 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1338518007345 active site 1338518007346 acyl-activating enzyme (AAE) consensus motif; other site 1338518007347 putative CoA binding site [chemical binding]; other site 1338518007348 AMP binding site [chemical binding]; other site 1338518007349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518007350 Coenzyme A binding pocket [chemical binding]; other site 1338518007351 FOG: CBS domain [General function prediction only]; Region: COG0517 1338518007352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1338518007353 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1338518007354 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1338518007355 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1338518007356 active site 1338518007357 Zn binding site [ion binding]; other site 1338518007358 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1338518007359 flagellar motor protein MotS; Reviewed; Region: PRK06925 1338518007360 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1338518007361 ligand binding site [chemical binding]; other site 1338518007362 flagellar motor protein MotP; Reviewed; Region: PRK06926 1338518007363 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1338518007364 catabolite control protein A; Region: ccpA; TIGR01481 1338518007365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518007366 DNA binding site [nucleotide binding] 1338518007367 domain linker motif; other site 1338518007368 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1338518007369 dimerization interface [polypeptide binding]; other site 1338518007370 effector binding site; other site 1338518007371 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1338518007372 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1338518007373 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1338518007374 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1338518007375 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1338518007376 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1338518007377 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1338518007378 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1338518007379 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1338518007380 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1338518007381 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1338518007382 putative tRNA-binding site [nucleotide binding]; other site 1338518007383 hypothetical protein; Provisional; Region: PRK13668 1338518007384 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1338518007385 catalytic residues [active] 1338518007386 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1338518007387 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1338518007388 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1338518007389 oligomer interface [polypeptide binding]; other site 1338518007390 active site 1338518007391 metal binding site [ion binding]; metal-binding site 1338518007392 Predicted small secreted protein [Function unknown]; Region: COG5584 1338518007393 malate dehydrogenase; Provisional; Region: PRK13529 1338518007394 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1338518007395 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1338518007396 NAD(P) binding site [chemical binding]; other site 1338518007397 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1338518007398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518007399 S-adenosylmethionine binding site [chemical binding]; other site 1338518007400 YtzH-like protein; Region: YtzH; pfam14165 1338518007401 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1338518007402 active site 1338518007403 ATP binding site [chemical binding]; other site 1338518007404 Phosphotransferase enzyme family; Region: APH; pfam01636 1338518007405 substrate binding site [chemical binding]; other site 1338518007406 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1338518007407 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1338518007408 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1338518007409 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1338518007410 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1338518007411 dipeptidase PepV; Reviewed; Region: PRK07318 1338518007412 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1338518007413 active site 1338518007414 metal binding site [ion binding]; metal-binding site 1338518007415 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1338518007416 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1338518007417 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1338518007418 Walker A/P-loop; other site 1338518007419 ATP binding site [chemical binding]; other site 1338518007420 Q-loop/lid; other site 1338518007421 ABC transporter signature motif; other site 1338518007422 Walker B; other site 1338518007423 D-loop; other site 1338518007424 H-loop/switch region; other site 1338518007425 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1338518007426 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1338518007427 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1338518007428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1338518007429 RNA binding surface [nucleotide binding]; other site 1338518007430 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1338518007431 active site 1338518007432 uracil binding [chemical binding]; other site 1338518007433 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1338518007434 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1338518007435 HI0933-like protein; Region: HI0933_like; pfam03486 1338518007436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1338518007437 BCCT family transporter; Region: BCCT; pfam02028 1338518007438 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1338518007439 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518007440 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518007441 DNA binding site [nucleotide binding] 1338518007442 domain linker motif; other site 1338518007443 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1338518007444 putative ligand binding site [chemical binding]; other site 1338518007445 putative dimerization interface [polypeptide binding]; other site 1338518007446 PBP superfamily domain; Region: PBP_like_2; cl17296 1338518007447 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1338518007448 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1338518007449 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1338518007450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518007451 dimer interface [polypeptide binding]; other site 1338518007452 conserved gate region; other site 1338518007453 putative PBP binding loops; other site 1338518007454 ABC-ATPase subunit interface; other site 1338518007455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1338518007456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518007457 dimer interface [polypeptide binding]; other site 1338518007458 conserved gate region; other site 1338518007459 putative PBP binding loops; other site 1338518007460 ABC-ATPase subunit interface; other site 1338518007461 alpha-galactosidase; Provisional; Region: PRK15076 1338518007462 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1338518007463 NAD binding site [chemical binding]; other site 1338518007464 sugar binding site [chemical binding]; other site 1338518007465 divalent metal binding site [ion binding]; other site 1338518007466 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1338518007467 dimer interface [polypeptide binding]; other site 1338518007468 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1338518007469 active site residue [active] 1338518007470 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1338518007471 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1338518007472 HIGH motif; other site 1338518007473 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1338518007474 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1338518007475 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1338518007476 active site 1338518007477 KMSKS motif; other site 1338518007478 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1338518007479 tRNA binding surface [nucleotide binding]; other site 1338518007480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518007481 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518007482 putative substrate translocation pore; other site 1338518007483 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1338518007484 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1338518007485 FtsX-like permease family; Region: FtsX; pfam02687 1338518007486 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1338518007487 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1338518007488 Walker A/P-loop; other site 1338518007489 ATP binding site [chemical binding]; other site 1338518007490 Q-loop/lid; other site 1338518007491 ABC transporter signature motif; other site 1338518007492 Walker B; other site 1338518007493 D-loop; other site 1338518007494 H-loop/switch region; other site 1338518007495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518007496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1338518007497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518007498 ATP binding site [chemical binding]; other site 1338518007499 Mg2+ binding site [ion binding]; other site 1338518007500 G-X-G motif; other site 1338518007501 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518007502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518007503 active site 1338518007504 phosphorylation site [posttranslational modification] 1338518007505 intermolecular recognition site; other site 1338518007506 dimerization interface [polypeptide binding]; other site 1338518007507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518007508 DNA binding site [nucleotide binding] 1338518007509 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1338518007510 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1338518007511 FtsX-like permease family; Region: FtsX; pfam02687 1338518007512 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1338518007513 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1338518007514 Walker A/P-loop; other site 1338518007515 ATP binding site [chemical binding]; other site 1338518007516 Q-loop/lid; other site 1338518007517 ABC transporter signature motif; other site 1338518007518 Walker B; other site 1338518007519 D-loop; other site 1338518007520 H-loop/switch region; other site 1338518007521 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1338518007522 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1338518007523 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1338518007524 Walker A/P-loop; other site 1338518007525 ATP binding site [chemical binding]; other site 1338518007526 Q-loop/lid; other site 1338518007527 ABC transporter signature motif; other site 1338518007528 Walker B; other site 1338518007529 D-loop; other site 1338518007530 H-loop/switch region; other site 1338518007531 Predicted transcriptional regulators [Transcription]; Region: COG1725 1338518007532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518007533 DNA-binding site [nucleotide binding]; DNA binding site 1338518007534 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1338518007535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518007536 putative DNA binding site [nucleotide binding]; other site 1338518007537 putative Zn2+ binding site [ion binding]; other site 1338518007538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518007539 putative substrate translocation pore; other site 1338518007540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518007541 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1338518007542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518007543 S-adenosylmethionine binding site [chemical binding]; other site 1338518007544 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1338518007545 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1338518007546 active site 1338518007547 catalytic site [active] 1338518007548 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1338518007549 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1338518007550 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1338518007551 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1338518007552 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1338518007553 trimer interface [polypeptide binding]; other site 1338518007554 putative metal binding site [ion binding]; other site 1338518007555 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1338518007556 Spore germination protein; Region: Spore_permease; cl17796 1338518007557 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1338518007558 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1338518007559 active site 1338518007560 dimer interface [polypeptide binding]; other site 1338518007561 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1338518007562 Ligand Binding Site [chemical binding]; other site 1338518007563 Molecular Tunnel; other site 1338518007564 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1338518007565 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1338518007566 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1338518007567 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1338518007568 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1338518007569 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1338518007570 active site 1338518007571 substrate-binding site [chemical binding]; other site 1338518007572 metal-binding site [ion binding] 1338518007573 ATP binding site [chemical binding]; other site 1338518007574 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1338518007575 Dienelactone hydrolase family; Region: DLH; pfam01738 1338518007576 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1338518007577 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1338518007578 NMT1-like family; Region: NMT1_2; pfam13379 1338518007579 substrate binding pocket [chemical binding]; other site 1338518007580 membrane-bound complex binding site; other site 1338518007581 hinge residues; other site 1338518007582 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1338518007583 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1338518007584 Walker A/P-loop; other site 1338518007585 ATP binding site [chemical binding]; other site 1338518007586 Q-loop/lid; other site 1338518007587 ABC transporter signature motif; other site 1338518007588 Walker B; other site 1338518007589 D-loop; other site 1338518007590 H-loop/switch region; other site 1338518007591 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1338518007592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518007593 dimer interface [polypeptide binding]; other site 1338518007594 conserved gate region; other site 1338518007595 putative PBP binding loops; other site 1338518007596 ABC-ATPase subunit interface; other site 1338518007597 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1338518007598 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1338518007599 nudix motif; other site 1338518007600 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1338518007601 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1338518007602 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1338518007603 dimerization interface [polypeptide binding]; other site 1338518007604 DPS ferroxidase diiron center [ion binding]; other site 1338518007605 ion pore; other site 1338518007606 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1338518007607 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1338518007608 active site clefts [active] 1338518007609 zinc binding site [ion binding]; other site 1338518007610 dimer interface [polypeptide binding]; other site 1338518007611 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1338518007612 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1338518007613 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1338518007614 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1338518007615 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1338518007616 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1338518007617 active site 1338518007618 octamer interface [polypeptide binding]; other site 1338518007619 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1338518007620 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1338518007621 acyl-activating enzyme (AAE) consensus motif; other site 1338518007622 putative AMP binding site [chemical binding]; other site 1338518007623 putative active site [active] 1338518007624 putative CoA binding site [chemical binding]; other site 1338518007625 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1338518007626 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1338518007627 substrate binding site [chemical binding]; other site 1338518007628 oxyanion hole (OAH) forming residues; other site 1338518007629 trimer interface [polypeptide binding]; other site 1338518007630 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1338518007631 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1338518007632 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1338518007633 dimer interface [polypeptide binding]; other site 1338518007634 tetramer interface [polypeptide binding]; other site 1338518007635 PYR/PP interface [polypeptide binding]; other site 1338518007636 TPP binding site [chemical binding]; other site 1338518007637 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1338518007638 TPP-binding site; other site 1338518007639 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1338518007640 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1338518007641 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1338518007642 TspO/MBR family; Region: TspO_MBR; cl01379 1338518007643 Predicted membrane protein [Function unknown]; Region: COG3859 1338518007644 DinB superfamily; Region: DinB_2; pfam12867 1338518007645 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1338518007646 MOSC domain; Region: MOSC; pfam03473 1338518007647 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1338518007648 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1338518007649 active site 1338518007650 NAD binding site [chemical binding]; other site 1338518007651 metal binding site [ion binding]; metal-binding site 1338518007652 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1338518007653 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1338518007654 tetramerization interface [polypeptide binding]; other site 1338518007655 NAD(P) binding site [chemical binding]; other site 1338518007656 catalytic residues [active] 1338518007657 Predicted transcriptional regulators [Transcription]; Region: COG1510 1338518007658 MarR family; Region: MarR_2; pfam12802 1338518007659 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1338518007660 TrkA-N domain; Region: TrkA_N; pfam02254 1338518007661 TrkA-C domain; Region: TrkA_C; pfam02080 1338518007662 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1338518007663 SH3-like domain; Region: SH3_8; pfam13457 1338518007664 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1338518007665 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1338518007666 heme-binding site [chemical binding]; other site 1338518007667 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1338518007668 FAD binding pocket [chemical binding]; other site 1338518007669 FAD binding motif [chemical binding]; other site 1338518007670 phosphate binding motif [ion binding]; other site 1338518007671 beta-alpha-beta structure motif; other site 1338518007672 NAD binding pocket [chemical binding]; other site 1338518007673 Heme binding pocket [chemical binding]; other site 1338518007674 Cupin; Region: Cupin_1; smart00835 1338518007675 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1338518007676 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1338518007677 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1338518007678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518007679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518007680 non-specific DNA binding site [nucleotide binding]; other site 1338518007681 salt bridge; other site 1338518007682 sequence-specific DNA binding site [nucleotide binding]; other site 1338518007683 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518007684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518007685 non-specific DNA binding site [nucleotide binding]; other site 1338518007686 salt bridge; other site 1338518007687 sequence-specific DNA binding site [nucleotide binding]; other site 1338518007688 Short C-terminal domain; Region: SHOCT; pfam09851 1338518007689 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1338518007690 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1338518007691 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1338518007692 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1338518007693 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1338518007694 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1338518007695 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1338518007696 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1338518007697 proposed catalytic triad [active] 1338518007698 conserved cys residue [active] 1338518007699 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1338518007700 Cache domain; Region: Cache_1; pfam02743 1338518007701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518007702 dimerization interface [polypeptide binding]; other site 1338518007703 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1338518007704 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518007705 dimer interface [polypeptide binding]; other site 1338518007706 putative CheW interface [polypeptide binding]; other site 1338518007707 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1338518007708 Cache domain; Region: Cache_1; pfam02743 1338518007709 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518007710 dimerization interface [polypeptide binding]; other site 1338518007711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518007712 dimer interface [polypeptide binding]; other site 1338518007713 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1338518007714 putative CheW interface [polypeptide binding]; other site 1338518007715 Tar ligand binding domain homologue; Region: TarH; pfam02203 1338518007716 Cache domain; Region: Cache_1; pfam02743 1338518007717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518007718 dimerization interface [polypeptide binding]; other site 1338518007719 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1338518007720 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518007721 dimer interface [polypeptide binding]; other site 1338518007722 putative CheW interface [polypeptide binding]; other site 1338518007723 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518007724 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1338518007725 Cache domain; Region: Cache_1; pfam02743 1338518007726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518007727 dimerization interface [polypeptide binding]; other site 1338518007728 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1338518007729 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1338518007730 dimer interface [polypeptide binding]; other site 1338518007731 putative CheW interface [polypeptide binding]; other site 1338518007732 transglutaminase; Provisional; Region: tgl; PRK03187 1338518007733 Nitronate monooxygenase; Region: NMO; pfam03060 1338518007734 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1338518007735 FMN binding site [chemical binding]; other site 1338518007736 substrate binding site [chemical binding]; other site 1338518007737 putative catalytic residue [active] 1338518007738 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1338518007739 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1338518007740 Ca binding site [ion binding]; other site 1338518007741 active site 1338518007742 catalytic site [active] 1338518007743 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1338518007744 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1338518007745 Domain of unknown function DUF21; Region: DUF21; pfam01595 1338518007746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1338518007747 Transporter associated domain; Region: CorC_HlyC; smart01091 1338518007748 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1338518007749 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1338518007750 Ion channel; Region: Ion_trans_2; pfam07885 1338518007751 TrkA-N domain; Region: TrkA_N; pfam02254 1338518007752 YugN-like family; Region: YugN; pfam08868 1338518007753 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1338518007754 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1338518007755 active site 1338518007756 dimer interface [polypeptide binding]; other site 1338518007757 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1338518007758 dimer interface [polypeptide binding]; other site 1338518007759 active site 1338518007760 Predicted flavoprotein [General function prediction only]; Region: COG0431 1338518007761 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1338518007762 Isochorismatase family; Region: Isochorismatase; pfam00857 1338518007763 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1338518007764 catalytic triad [active] 1338518007765 dimer interface [polypeptide binding]; other site 1338518007766 conserved cis-peptide bond; other site 1338518007767 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1338518007768 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1338518007769 dimer interface [polypeptide binding]; other site 1338518007770 active site 1338518007771 metal binding site [ion binding]; metal-binding site 1338518007772 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1338518007773 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1338518007774 dimer interface [polypeptide binding]; other site 1338518007775 active site 1338518007776 metal binding site [ion binding]; metal-binding site 1338518007777 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1338518007778 general stress protein 13; Validated; Region: PRK08059 1338518007779 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1338518007780 RNA binding site [nucleotide binding]; other site 1338518007781 hypothetical protein; Validated; Region: PRK07682 1338518007782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518007783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518007784 homodimer interface [polypeptide binding]; other site 1338518007785 catalytic residue [active] 1338518007786 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1338518007787 AsnC family; Region: AsnC_trans_reg; pfam01037 1338518007788 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1338518007789 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1338518007790 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1338518007791 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1338518007792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518007793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518007794 homodimer interface [polypeptide binding]; other site 1338518007795 catalytic residue [active] 1338518007796 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518007797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518007798 dimer interface [polypeptide binding]; other site 1338518007799 phosphorylation site [posttranslational modification] 1338518007800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518007801 ATP binding site [chemical binding]; other site 1338518007802 Mg2+ binding site [ion binding]; other site 1338518007803 G-X-G motif; other site 1338518007804 Kinase associated protein B; Region: KapB; pfam08810 1338518007805 drug efflux system protein MdtG; Provisional; Region: PRK09874 1338518007806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518007807 putative substrate translocation pore; other site 1338518007808 Transglycosylase; Region: Transgly; pfam00912 1338518007809 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1338518007810 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1338518007811 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1338518007812 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1338518007813 PAS domain; Region: PAS; smart00091 1338518007814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518007815 ATP binding site [chemical binding]; other site 1338518007816 Mg2+ binding site [ion binding]; other site 1338518007817 G-X-G motif; other site 1338518007818 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1338518007819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518007820 active site 1338518007821 phosphorylation site [posttranslational modification] 1338518007822 intermolecular recognition site; other site 1338518007823 dimerization interface [polypeptide binding]; other site 1338518007824 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1338518007825 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1338518007826 ligand binding site [chemical binding]; other site 1338518007827 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1338518007828 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1338518007829 Walker A/P-loop; other site 1338518007830 ATP binding site [chemical binding]; other site 1338518007831 Q-loop/lid; other site 1338518007832 ABC transporter signature motif; other site 1338518007833 Walker B; other site 1338518007834 D-loop; other site 1338518007835 H-loop/switch region; other site 1338518007836 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1338518007837 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1338518007838 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1338518007839 TM-ABC transporter signature motif; other site 1338518007840 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1338518007841 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1338518007842 TM-ABC transporter signature motif; other site 1338518007843 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1338518007844 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1338518007845 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1338518007846 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1338518007847 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1338518007848 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1338518007849 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1338518007850 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1338518007851 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1338518007852 CoenzymeA binding site [chemical binding]; other site 1338518007853 subunit interaction site [polypeptide binding]; other site 1338518007854 PHB binding site; other site 1338518007855 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518007856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518007857 active site 1338518007858 phosphorylation site [posttranslational modification] 1338518007859 intermolecular recognition site; other site 1338518007860 dimerization interface [polypeptide binding]; other site 1338518007861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518007862 DNA binding residues [nucleotide binding] 1338518007863 dimerization interface [polypeptide binding]; other site 1338518007864 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1338518007865 DegQ (SacQ) family; Region: DegQ; pfam08181 1338518007866 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1338518007867 EAL domain; Region: EAL; pfam00563 1338518007868 Isochorismatase family; Region: Isochorismatase; pfam00857 1338518007869 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1338518007870 catalytic triad [active] 1338518007871 conserved cis-peptide bond; other site 1338518007872 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1338518007873 YueH-like protein; Region: YueH; pfam14166 1338518007874 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1338518007875 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1338518007876 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1338518007877 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1338518007878 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1338518007879 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518007880 Zn2+ binding site [ion binding]; other site 1338518007881 Mg2+ binding site [ion binding]; other site 1338518007882 short chain dehydrogenase; Provisional; Region: PRK06924 1338518007883 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1338518007884 NADP binding site [chemical binding]; other site 1338518007885 homodimer interface [polypeptide binding]; other site 1338518007886 active site 1338518007887 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1338518007888 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1338518007889 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1338518007890 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1338518007891 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1338518007892 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1338518007893 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1338518007894 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1338518007895 Domain of unknown function DUF87; Region: DUF87; pfam01935 1338518007896 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1338518007897 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1338518007898 Uncharacterized small protein [Function unknown]; Region: COG5417 1338518007899 Ubiquitin homologues; Region: UBQ; smart00213 1338518007900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1338518007901 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1338518007902 CodY GAF-like domain; Region: CodY; pfam06018 1338518007903 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1338518007904 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1338518007905 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1338518007906 hexamer interface [polypeptide binding]; other site 1338518007907 ligand binding site [chemical binding]; other site 1338518007908 putative active site [active] 1338518007909 NAD(P) binding site [chemical binding]; other site 1338518007910 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1338518007911 MbtH-like protein; Region: MbtH; cl01279 1338518007912 Condensation domain; Region: Condensation; pfam00668 1338518007913 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1338518007914 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1338518007915 acyl-activating enzyme (AAE) consensus motif; other site 1338518007916 AMP binding site [chemical binding]; other site 1338518007917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518007918 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1338518007919 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1338518007920 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1338518007921 acyl-activating enzyme (AAE) consensus motif; other site 1338518007922 AMP binding site [chemical binding]; other site 1338518007923 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1338518007924 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1338518007925 hydrophobic substrate binding pocket; other site 1338518007926 Isochorismatase family; Region: Isochorismatase; pfam00857 1338518007927 active site 1338518007928 conserved cis-peptide bond; other site 1338518007929 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1338518007930 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1338518007931 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1338518007932 acyl-activating enzyme (AAE) consensus motif; other site 1338518007933 active site 1338518007934 AMP binding site [chemical binding]; other site 1338518007935 substrate binding site [chemical binding]; other site 1338518007936 isochorismate synthase DhbC; Validated; Region: PRK06923 1338518007937 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1338518007938 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1338518007939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518007940 NAD(P) binding site [chemical binding]; other site 1338518007941 active site 1338518007942 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1338518007943 Putative esterase; Region: Esterase; pfam00756 1338518007944 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1338518007945 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1338518007946 Moco binding site; other site 1338518007947 metal coordination site [ion binding]; other site 1338518007948 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1338518007949 Predicted permease [General function prediction only]; Region: COG2056 1338518007950 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1338518007951 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1338518007952 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1338518007953 interface (dimer of trimers) [polypeptide binding]; other site 1338518007954 Substrate-binding/catalytic site; other site 1338518007955 Zn-binding sites [ion binding]; other site 1338518007956 Divergent PAP2 family; Region: DUF212; pfam02681 1338518007957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1338518007958 Putative membrane protein; Region: YuiB; pfam14068 1338518007959 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1338518007960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518007961 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1338518007962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1338518007963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518007964 Integral membrane protein DUF95; Region: DUF95; pfam01944 1338518007965 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1338518007966 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1338518007967 Walker A/P-loop; other site 1338518007968 ATP binding site [chemical binding]; other site 1338518007969 Q-loop/lid; other site 1338518007970 ABC transporter signature motif; other site 1338518007971 Walker B; other site 1338518007972 D-loop; other site 1338518007973 H-loop/switch region; other site 1338518007974 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1338518007975 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1338518007976 putative NAD(P) binding site [chemical binding]; other site 1338518007977 active site 1338518007978 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1338518007979 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1338518007980 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1338518007981 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1338518007982 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1338518007983 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1338518007984 Nucleoside recognition; Region: Gate; pfam07670 1338518007985 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1338518007986 hypothetical protein; Provisional; Region: PRK13669 1338518007987 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1338518007988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518007989 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1338518007990 NifU-like domain; Region: NifU; pfam01106 1338518007991 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1338518007992 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1338518007993 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1338518007994 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1338518007995 homoserine kinase; Provisional; Region: PRK01212 1338518007996 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1338518007997 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1338518007998 homoserine dehydrogenase; Provisional; Region: PRK06349 1338518007999 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1338518008000 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1338518008001 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1338518008002 spore coat protein YutH; Region: spore_yutH; TIGR02905 1338518008003 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1338518008004 tetramer interfaces [polypeptide binding]; other site 1338518008005 binuclear metal-binding site [ion binding]; other site 1338518008006 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1338518008007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518008008 active site 1338518008009 motif I; other site 1338518008010 motif II; other site 1338518008011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518008012 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1338518008013 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1338518008014 lipoyl synthase; Provisional; Region: PRK05481 1338518008015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518008016 FeS/SAM binding site; other site 1338518008017 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1338518008018 Peptidase family M23; Region: Peptidase_M23; pfam01551 1338518008019 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1338518008020 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1338518008021 active site 1338518008022 metal binding site [ion binding]; metal-binding site 1338518008023 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1338518008024 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1338518008025 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1338518008026 allantoinase; Provisional; Region: PRK06189 1338518008027 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1338518008028 active site 1338518008029 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1338518008030 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1338518008031 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1338518008032 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1338518008033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518008035 putative substrate translocation pore; other site 1338518008036 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1338518008037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1338518008038 catalytic residue [active] 1338518008039 allantoate amidohydrolase; Reviewed; Region: PRK09290 1338518008040 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1338518008041 active site 1338518008042 metal binding site [ion binding]; metal-binding site 1338518008043 dimer interface [polypeptide binding]; other site 1338518008044 Endonuclease I; Region: Endonuclease_1; cl01003 1338518008045 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1338518008046 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1338518008047 Walker A/P-loop; other site 1338518008048 ATP binding site [chemical binding]; other site 1338518008049 Q-loop/lid; other site 1338518008050 ABC transporter signature motif; other site 1338518008051 Walker B; other site 1338518008052 D-loop; other site 1338518008053 H-loop/switch region; other site 1338518008054 TOBE domain; Region: TOBE_2; pfam08402 1338518008055 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1338518008056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518008057 DNA-binding site [nucleotide binding]; DNA binding site 1338518008058 UTRA domain; Region: UTRA; pfam07702 1338518008059 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1338518008060 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1338518008061 substrate binding site [chemical binding]; other site 1338518008062 ATP binding site [chemical binding]; other site 1338518008063 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1338518008064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518008065 dimer interface [polypeptide binding]; other site 1338518008066 conserved gate region; other site 1338518008067 putative PBP binding loops; other site 1338518008068 ABC-ATPase subunit interface; other site 1338518008069 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1338518008070 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1338518008071 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1338518008072 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1338518008073 putative active site [active] 1338518008074 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1338518008075 dimer interface [polypeptide binding]; other site 1338518008076 active site 1338518008077 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1338518008078 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1338518008079 DNA binding residues [nucleotide binding] 1338518008080 dimer interface [polypeptide binding]; other site 1338518008081 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1338518008082 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1338518008083 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1338518008084 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1338518008085 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1338518008086 GIY-YIG motif/motif A; other site 1338518008087 active site 1338518008088 catalytic site [active] 1338518008089 putative DNA binding site [nucleotide binding]; other site 1338518008090 metal binding site [ion binding]; metal-binding site 1338518008091 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1338518008092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518008093 S-adenosylmethionine binding site [chemical binding]; other site 1338518008094 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1338518008095 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1338518008096 chitosan binding site [chemical binding]; other site 1338518008097 catalytic residues [active] 1338518008098 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1338518008099 FeS assembly protein SufB; Region: sufB; TIGR01980 1338518008100 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1338518008101 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1338518008102 trimerization site [polypeptide binding]; other site 1338518008103 active site 1338518008104 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1338518008105 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1338518008106 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1338518008107 catalytic residue [active] 1338518008108 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1338518008109 FeS assembly protein SufD; Region: sufD; TIGR01981 1338518008110 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1338518008111 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1338518008112 Walker A/P-loop; other site 1338518008113 ATP binding site [chemical binding]; other site 1338518008114 Q-loop/lid; other site 1338518008115 ABC transporter signature motif; other site 1338518008116 Walker B; other site 1338518008117 D-loop; other site 1338518008118 H-loop/switch region; other site 1338518008119 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1338518008120 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1338518008121 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1338518008122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518008123 dimer interface [polypeptide binding]; other site 1338518008124 conserved gate region; other site 1338518008125 ABC-ATPase subunit interface; other site 1338518008126 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1338518008127 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1338518008128 Walker A/P-loop; other site 1338518008129 ATP binding site [chemical binding]; other site 1338518008130 Q-loop/lid; other site 1338518008131 ABC transporter signature motif; other site 1338518008132 Walker B; other site 1338518008133 D-loop; other site 1338518008134 H-loop/switch region; other site 1338518008135 NIL domain; Region: NIL; pfam09383 1338518008136 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1338518008137 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1338518008138 putative active site [active] 1338518008139 putative metal binding site [ion binding]; other site 1338518008140 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1338518008141 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1338518008142 lipoyl attachment site [posttranslational modification]; other site 1338518008143 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1338518008144 ArsC family; Region: ArsC; pfam03960 1338518008145 putative ArsC-like catalytic residues; other site 1338518008146 putative TRX-like catalytic residues [active] 1338518008147 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1338518008148 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1338518008149 active site 1338518008150 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1338518008151 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1338518008152 dimer interface [polypeptide binding]; other site 1338518008153 active site 1338518008154 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1338518008155 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1338518008156 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1338518008157 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1338518008158 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1338518008159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1338518008160 substrate binding site [chemical binding]; other site 1338518008161 oxyanion hole (OAH) forming residues; other site 1338518008162 trimer interface [polypeptide binding]; other site 1338518008163 YuzL-like protein; Region: YuzL; pfam14115 1338518008164 Proline dehydrogenase; Region: Pro_dh; cl03282 1338518008165 Coat F domain; Region: Coat_F; pfam07875 1338518008166 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518008167 MarR family; Region: MarR; pfam01047 1338518008168 MarR family; Region: MarR_2; cl17246 1338518008169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008170 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518008171 putative substrate translocation pore; other site 1338518008172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518008174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518008175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518008176 dimerization interface [polypeptide binding]; other site 1338518008177 acetoacetate decarboxylase; Provisional; Region: PRK02265 1338518008178 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1338518008179 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1338518008180 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1338518008181 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1338518008182 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1338518008183 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1338518008184 Walker A/P-loop; other site 1338518008185 ATP binding site [chemical binding]; other site 1338518008186 Q-loop/lid; other site 1338518008187 ABC transporter signature motif; other site 1338518008188 Walker B; other site 1338518008189 D-loop; other site 1338518008190 H-loop/switch region; other site 1338518008191 YusW-like protein; Region: YusW; pfam14039 1338518008192 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1338518008193 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1338518008194 active site 1338518008195 Zn binding site [ion binding]; other site 1338518008196 short chain dehydrogenase; Provisional; Region: PRK06914 1338518008197 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1338518008198 NADP binding site [chemical binding]; other site 1338518008199 active site 1338518008200 steroid binding site; other site 1338518008201 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1338518008202 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1338518008203 dimerization interface [polypeptide binding]; other site 1338518008204 DPS ferroxidase diiron center [ion binding]; other site 1338518008205 ion pore; other site 1338518008206 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1338518008207 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1338518008208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1338518008209 protein binding site [polypeptide binding]; other site 1338518008210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518008211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518008212 active site 1338518008213 phosphorylation site [posttranslational modification] 1338518008214 intermolecular recognition site; other site 1338518008215 dimerization interface [polypeptide binding]; other site 1338518008216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518008217 DNA binding site [nucleotide binding] 1338518008218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518008219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518008220 dimerization interface [polypeptide binding]; other site 1338518008221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518008222 dimer interface [polypeptide binding]; other site 1338518008223 phosphorylation site [posttranslational modification] 1338518008224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518008225 ATP binding site [chemical binding]; other site 1338518008226 Mg2+ binding site [ion binding]; other site 1338518008227 G-X-G motif; other site 1338518008228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518008229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518008230 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1338518008231 Class II fumarases; Region: Fumarase_classII; cd01362 1338518008232 active site 1338518008233 tetramer interface [polypeptide binding]; other site 1338518008234 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1338518008235 Spore germination protein; Region: Spore_permease; pfam03845 1338518008236 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1338518008237 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1338518008238 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1338518008239 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518008240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518008241 active site 1338518008242 phosphorylation site [posttranslational modification] 1338518008243 intermolecular recognition site; other site 1338518008244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518008245 DNA binding residues [nucleotide binding] 1338518008246 dimerization interface [polypeptide binding]; other site 1338518008247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1338518008248 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518008249 dimerization interface [polypeptide binding]; other site 1338518008250 Histidine kinase; Region: HisKA_3; pfam07730 1338518008251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518008252 ATP binding site [chemical binding]; other site 1338518008253 Mg2+ binding site [ion binding]; other site 1338518008254 G-X-G motif; other site 1338518008255 Predicted membrane protein [Function unknown]; Region: COG4758 1338518008256 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1338518008257 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1338518008258 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1338518008259 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1338518008260 PspA/IM30 family; Region: PspA_IM30; pfam04012 1338518008261 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1338518008262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008263 H+ Antiporter protein; Region: 2A0121; TIGR00900 1338518008264 putative substrate translocation pore; other site 1338518008265 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1338518008266 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1338518008267 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1338518008268 Walker A/P-loop; other site 1338518008269 ATP binding site [chemical binding]; other site 1338518008270 Q-loop/lid; other site 1338518008271 ABC transporter signature motif; other site 1338518008272 Walker B; other site 1338518008273 D-loop; other site 1338518008274 H-loop/switch region; other site 1338518008275 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1338518008276 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1338518008277 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1338518008278 putative binding site residues; other site 1338518008279 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1338518008280 classical (c) SDRs; Region: SDR_c; cd05233 1338518008281 NAD(P) binding site [chemical binding]; other site 1338518008282 active site 1338518008283 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1338518008284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518008285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518008286 dimer interface [polypeptide binding]; other site 1338518008287 phosphorylation site [posttranslational modification] 1338518008288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518008289 ATP binding site [chemical binding]; other site 1338518008290 Mg2+ binding site [ion binding]; other site 1338518008291 G-X-G motif; other site 1338518008292 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518008293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518008294 active site 1338518008295 phosphorylation site [posttranslational modification] 1338518008296 intermolecular recognition site; other site 1338518008297 dimerization interface [polypeptide binding]; other site 1338518008298 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518008299 DNA binding site [nucleotide binding] 1338518008300 hypothetical protein; Provisional; Region: PRK14082 1338518008301 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1338518008302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1338518008303 DNA binding residues [nucleotide binding] 1338518008304 YvrJ protein family; Region: YvrJ; pfam12841 1338518008305 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1338518008306 Cupin; Region: Cupin_1; smart00835 1338518008307 Cupin; Region: Cupin_1; smart00835 1338518008308 Regulatory protein YrvL; Region: YrvL; pfam14184 1338518008309 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1338518008310 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1338518008311 Walker A/P-loop; other site 1338518008312 ATP binding site [chemical binding]; other site 1338518008313 Q-loop/lid; other site 1338518008314 ABC transporter signature motif; other site 1338518008315 Walker B; other site 1338518008316 D-loop; other site 1338518008317 H-loop/switch region; other site 1338518008318 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1338518008319 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518008320 ABC-ATPase subunit interface; other site 1338518008321 dimer interface [polypeptide binding]; other site 1338518008322 putative PBP binding regions; other site 1338518008323 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1338518008324 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518008325 ABC-ATPase subunit interface; other site 1338518008326 dimer interface [polypeptide binding]; other site 1338518008327 putative PBP binding regions; other site 1338518008328 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1338518008329 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1338518008330 putative ligand binding residues [chemical binding]; other site 1338518008331 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1338518008332 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1338518008333 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1338518008334 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 1338518008335 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1338518008336 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1338518008337 Sulfatase; Region: Sulfatase; pfam00884 1338518008338 DNA binding domain, excisionase family; Region: excise; TIGR01764 1338518008339 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1338518008340 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1338518008341 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1338518008342 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518008343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518008344 active site 1338518008345 phosphorylation site [posttranslational modification] 1338518008346 intermolecular recognition site; other site 1338518008347 dimerization interface [polypeptide binding]; other site 1338518008348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518008349 DNA binding residues [nucleotide binding] 1338518008350 dimerization interface [polypeptide binding]; other site 1338518008351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1338518008352 Histidine kinase; Region: HisKA_3; pfam07730 1338518008353 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1338518008354 ATP binding site [chemical binding]; other site 1338518008355 Mg2+ binding site [ion binding]; other site 1338518008356 G-X-G motif; other site 1338518008357 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1338518008358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518008359 Walker A/P-loop; other site 1338518008360 ATP binding site [chemical binding]; other site 1338518008361 Q-loop/lid; other site 1338518008362 ABC transporter signature motif; other site 1338518008363 Walker B; other site 1338518008364 D-loop; other site 1338518008365 H-loop/switch region; other site 1338518008366 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1338518008367 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1338518008368 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1338518008369 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1338518008370 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1338518008371 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1338518008372 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1338518008373 active site 1338518008374 catalytic tetrad [active] 1338518008375 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1338518008376 sulfite reductase subunit beta; Provisional; Region: PRK13504 1338518008377 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1338518008378 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1338518008379 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1338518008380 Flavodoxin; Region: Flavodoxin_1; pfam00258 1338518008381 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1338518008382 FAD binding pocket [chemical binding]; other site 1338518008383 FAD binding motif [chemical binding]; other site 1338518008384 catalytic residues [active] 1338518008385 NAD binding pocket [chemical binding]; other site 1338518008386 phosphate binding motif [ion binding]; other site 1338518008387 beta-alpha-beta structure motif; other site 1338518008388 Predicted membrane protein [Function unknown]; Region: COG2860 1338518008389 UPF0126 domain; Region: UPF0126; pfam03458 1338518008390 UPF0126 domain; Region: UPF0126; pfam03458 1338518008391 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 1338518008392 active site 1338518008393 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1338518008394 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1338518008395 Thioredoxin; Region: Thioredoxin_4; cl17273 1338518008396 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1338518008397 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1338518008398 metal-binding site [ion binding] 1338518008399 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1338518008400 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1338518008401 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1338518008402 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1338518008403 metal-binding site [ion binding] 1338518008404 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1338518008405 putative homodimer interface [polypeptide binding]; other site 1338518008406 putative homotetramer interface [polypeptide binding]; other site 1338518008407 putative allosteric switch controlling residues; other site 1338518008408 putative metal binding site [ion binding]; other site 1338518008409 putative homodimer-homodimer interface [polypeptide binding]; other site 1338518008410 putative oxidoreductase; Provisional; Region: PRK11579 1338518008411 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1338518008412 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1338518008413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518008414 salt bridge; other site 1338518008415 non-specific DNA binding site [nucleotide binding]; other site 1338518008416 sequence-specific DNA binding site [nucleotide binding]; other site 1338518008417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518008419 putative substrate translocation pore; other site 1338518008420 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1338518008421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1338518008422 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1338518008423 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1338518008424 active site 1338518008425 non-prolyl cis peptide bond; other site 1338518008426 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1338518008427 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1338518008428 Walker A/P-loop; other site 1338518008429 ATP binding site [chemical binding]; other site 1338518008430 Q-loop/lid; other site 1338518008431 ABC transporter signature motif; other site 1338518008432 Walker B; other site 1338518008433 D-loop; other site 1338518008434 H-loop/switch region; other site 1338518008435 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1338518008436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518008437 dimer interface [polypeptide binding]; other site 1338518008438 conserved gate region; other site 1338518008439 putative PBP binding loops; other site 1338518008440 ABC-ATPase subunit interface; other site 1338518008441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518008442 dimer interface [polypeptide binding]; other site 1338518008443 conserved gate region; other site 1338518008444 putative PBP binding loops; other site 1338518008445 ABC-ATPase subunit interface; other site 1338518008446 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1338518008447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1338518008448 substrate binding pocket [chemical binding]; other site 1338518008449 membrane-bound complex binding site; other site 1338518008450 hinge residues; other site 1338518008451 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1338518008452 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1338518008453 substrate binding pocket [chemical binding]; other site 1338518008454 membrane-bound complex binding site; other site 1338518008455 hinge residues; other site 1338518008456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1338518008457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518008458 Coenzyme A binding pocket [chemical binding]; other site 1338518008459 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1338518008460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518008461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518008462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518008463 dimerization interface [polypeptide binding]; other site 1338518008464 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1338518008465 RNAase interaction site [polypeptide binding]; other site 1338518008466 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1338518008467 SmpB-tmRNA interface; other site 1338518008468 putative transporter; Provisional; Region: PRK03699 1338518008469 ribonuclease R; Region: RNase_R; TIGR02063 1338518008470 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1338518008471 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1338518008472 RNB domain; Region: RNB; pfam00773 1338518008473 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1338518008474 RNA binding site [nucleotide binding]; other site 1338518008475 Esterase/lipase [General function prediction only]; Region: COG1647 1338518008476 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1338518008477 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1338518008478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518008479 salt bridge; other site 1338518008480 non-specific DNA binding site [nucleotide binding]; other site 1338518008481 sequence-specific DNA binding site [nucleotide binding]; other site 1338518008482 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518008483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518008484 non-specific DNA binding site [nucleotide binding]; other site 1338518008485 salt bridge; other site 1338518008486 sequence-specific DNA binding site [nucleotide binding]; other site 1338518008487 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518008488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518008489 non-specific DNA binding site [nucleotide binding]; other site 1338518008490 salt bridge; other site 1338518008491 sequence-specific DNA binding site [nucleotide binding]; other site 1338518008492 Predicted transcriptional regulators [Transcription]; Region: COG1733 1338518008493 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1338518008494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518008495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518008496 dimer interface [polypeptide binding]; other site 1338518008497 phosphorylation site [posttranslational modification] 1338518008498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518008499 ATP binding site [chemical binding]; other site 1338518008500 Mg2+ binding site [ion binding]; other site 1338518008501 G-X-G motif; other site 1338518008502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518008503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518008504 active site 1338518008505 phosphorylation site [posttranslational modification] 1338518008506 intermolecular recognition site; other site 1338518008507 dimerization interface [polypeptide binding]; other site 1338518008508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518008509 DNA binding site [nucleotide binding] 1338518008510 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1338518008511 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1338518008512 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1338518008513 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1338518008514 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1338518008515 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1338518008516 Walker A/P-loop; other site 1338518008517 ATP binding site [chemical binding]; other site 1338518008518 Q-loop/lid; other site 1338518008519 ABC transporter signature motif; other site 1338518008520 Walker B; other site 1338518008521 D-loop; other site 1338518008522 H-loop/switch region; other site 1338518008523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518008524 dimer interface [polypeptide binding]; other site 1338518008525 conserved gate region; other site 1338518008526 putative PBP binding loops; other site 1338518008527 ABC-ATPase subunit interface; other site 1338518008528 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1338518008529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518008530 dimer interface [polypeptide binding]; other site 1338518008531 conserved gate region; other site 1338518008532 putative PBP binding loops; other site 1338518008533 ABC-ATPase subunit interface; other site 1338518008534 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1338518008535 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1338518008536 Walker A/P-loop; other site 1338518008537 ATP binding site [chemical binding]; other site 1338518008538 Q-loop/lid; other site 1338518008539 ABC transporter signature motif; other site 1338518008540 Walker B; other site 1338518008541 D-loop; other site 1338518008542 H-loop/switch region; other site 1338518008543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1338518008544 Predicted transcriptional regulators [Transcription]; Region: COG1510 1338518008545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518008546 putative DNA binding site [nucleotide binding]; other site 1338518008547 putative Zn2+ binding site [ion binding]; other site 1338518008548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518008549 dimer interface [polypeptide binding]; other site 1338518008550 conserved gate region; other site 1338518008551 putative PBP binding loops; other site 1338518008552 ABC-ATPase subunit interface; other site 1338518008553 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1338518008554 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1338518008555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1338518008556 dimer interface [polypeptide binding]; other site 1338518008557 conserved gate region; other site 1338518008558 putative PBP binding loops; other site 1338518008559 ABC-ATPase subunit interface; other site 1338518008560 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1338518008561 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1338518008562 Walker A/P-loop; other site 1338518008563 ATP binding site [chemical binding]; other site 1338518008564 Q-loop/lid; other site 1338518008565 ABC transporter signature motif; other site 1338518008566 Walker B; other site 1338518008567 D-loop; other site 1338518008568 H-loop/switch region; other site 1338518008569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1338518008570 Predicted transcriptional regulators [Transcription]; Region: COG1510 1338518008571 MarR family; Region: MarR_2; pfam12802 1338518008572 membrane protein, MarC family; Region: TIGR00427 1338518008573 Predicted membrane protein [Function unknown]; Region: COG4640 1338518008574 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1338518008575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518008576 Coenzyme A binding pocket [chemical binding]; other site 1338518008577 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1338518008578 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1338518008579 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1338518008580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1338518008581 NAD(P) binding site [chemical binding]; other site 1338518008582 active site 1338518008583 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1338518008584 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1338518008585 inhibitor-cofactor binding pocket; inhibition site 1338518008586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518008587 catalytic residue [active] 1338518008588 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1338518008589 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1338518008590 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1338518008591 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1338518008592 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1338518008593 putative integrin binding motif; other site 1338518008594 PA/protease domain interface [polypeptide binding]; other site 1338518008595 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1338518008596 Peptidase family M28; Region: Peptidase_M28; pfam04389 1338518008597 metal binding site [ion binding]; metal-binding site 1338518008598 enolase; Provisional; Region: eno; PRK00077 1338518008599 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1338518008600 dimer interface [polypeptide binding]; other site 1338518008601 metal binding site [ion binding]; metal-binding site 1338518008602 substrate binding pocket [chemical binding]; other site 1338518008603 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1338518008604 phosphoglyceromutase; Provisional; Region: PRK05434 1338518008605 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1338518008606 triosephosphate isomerase; Provisional; Region: PRK14565 1338518008607 substrate binding site [chemical binding]; other site 1338518008608 dimer interface [polypeptide binding]; other site 1338518008609 catalytic triad [active] 1338518008610 Phosphoglycerate kinase; Region: PGK; pfam00162 1338518008611 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1338518008612 substrate binding site [chemical binding]; other site 1338518008613 hinge regions; other site 1338518008614 ADP binding site [chemical binding]; other site 1338518008615 catalytic site [active] 1338518008616 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1338518008617 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1338518008618 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1338518008619 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1338518008620 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1338518008621 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1338518008622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008623 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1338518008624 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1338518008625 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1338518008626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518008627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518008628 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518008629 dimerization interface [polypeptide binding]; other site 1338518008630 EamA-like transporter family; Region: EamA; pfam00892 1338518008631 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1338518008632 EamA-like transporter family; Region: EamA; pfam00892 1338518008633 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1338518008634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1338518008635 active site 1338518008636 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518008637 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518008638 DNA binding site [nucleotide binding] 1338518008639 domain linker motif; other site 1338518008640 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1338518008641 putative ligand binding site [chemical binding]; other site 1338518008642 putative dimerization interface [polypeptide binding]; other site 1338518008643 Predicted membrane protein [Function unknown]; Region: COG2364 1338518008644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518008645 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1338518008646 active site 1338518008647 motif I; other site 1338518008648 motif II; other site 1338518008649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518008650 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1338518008651 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1338518008652 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1338518008653 putative active site [active] 1338518008654 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1338518008655 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1338518008656 N- and C-terminal domain interface [polypeptide binding]; other site 1338518008657 active site 1338518008658 catalytic site [active] 1338518008659 metal binding site [ion binding]; metal-binding site 1338518008660 carbohydrate binding site [chemical binding]; other site 1338518008661 ATP binding site [chemical binding]; other site 1338518008662 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1338518008663 GntP family permease; Region: GntP_permease; pfam02447 1338518008664 iron-sulfur cluster-binding protein; Region: TIGR00273 1338518008665 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1338518008666 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1338518008667 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1338518008668 Cysteine-rich domain; Region: CCG; pfam02754 1338518008669 Cysteine-rich domain; Region: CCG; pfam02754 1338518008670 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:15064768, 15256574, 19632206, 18831049; Product type r:regulator 1338518008671 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:15064768, 15256574, 19632206, 18831049; Product type r:regulator 1338518008672 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1338518008673 L-lactate permease; Region: Lactate_perm; pfam02652 1338518008674 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1338518008675 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1338518008676 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1338518008677 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1338518008678 YvfG protein; Region: YvfG; pfam09628 1338518008679 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1338518008680 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1338518008681 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1338518008682 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1338518008683 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1338518008684 inhibitor-cofactor binding pocket; inhibition site 1338518008685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518008686 catalytic residue [active] 1338518008687 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1338518008688 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1338518008689 putative trimer interface [polypeptide binding]; other site 1338518008690 putative CoA binding site [chemical binding]; other site 1338518008691 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1338518008692 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1338518008693 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1338518008694 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1338518008695 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1338518008696 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1338518008697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1338518008698 active site 1338518008699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1338518008700 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1338518008701 putative ADP-binding pocket [chemical binding]; other site 1338518008702 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1338518008703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1338518008704 putative ADP-binding pocket [chemical binding]; other site 1338518008705 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1338518008706 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1338518008707 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1338518008708 Chain length determinant protein; Region: Wzz; cl15801 1338518008709 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518008710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518008711 non-specific DNA binding site [nucleotide binding]; other site 1338518008712 salt bridge; other site 1338518008713 sequence-specific DNA binding site [nucleotide binding]; other site 1338518008714 Anti-repressor SinI; Region: SinI; pfam08671 1338518008715 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1338518008716 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1338518008717 substrate binding pocket [chemical binding]; other site 1338518008718 catalytic triad [active] 1338518008719 RibD C-terminal domain; Region: RibD_C; cl17279 1338518008720 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1338518008721 Predicted membrane protein [Function unknown]; Region: COG2364 1338518008722 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518008723 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1338518008724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518008725 Coenzyme A binding pocket [chemical binding]; other site 1338518008726 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1338518008727 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 1338518008728 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1338518008729 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1338518008730 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1338518008731 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1338518008732 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1338518008733 substrate binding [chemical binding]; other site 1338518008734 active site 1338518008735 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1338518008736 galactoside permease; Reviewed; Region: lacY; PRK09528 1338518008737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008738 putative substrate translocation pore; other site 1338518008739 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518008740 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518008741 DNA binding site [nucleotide binding] 1338518008742 domain linker motif; other site 1338518008743 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1338518008744 dimerization interface [polypeptide binding]; other site 1338518008745 ligand binding site [chemical binding]; other site 1338518008746 sodium binding site [ion binding]; other site 1338518008747 Clp protease; Region: CLP_protease; pfam00574 1338518008748 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1338518008749 oligomer interface [polypeptide binding]; other site 1338518008750 active site residues [active] 1338518008751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518008752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518008753 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518008754 dimerization interface [polypeptide binding]; other site 1338518008755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1338518008756 benzoate transport; Region: 2A0115; TIGR00895 1338518008757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008758 putative substrate translocation pore; other site 1338518008759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008760 TIGR00730 family protein; Region: TIGR00730 1338518008761 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1338518008762 metal binding site [ion binding]; metal-binding site 1338518008763 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1338518008764 active site clefts [active] 1338518008765 zinc binding site [ion binding]; other site 1338518008766 dimer interface [polypeptide binding]; other site 1338518008767 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1338518008768 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1338518008769 dimerization interface [polypeptide binding]; other site 1338518008770 ligand binding site [chemical binding]; other site 1338518008771 NADP binding site [chemical binding]; other site 1338518008772 catalytic site [active] 1338518008773 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1338518008774 active site 1338518008775 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1338518008776 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1338518008777 dimerization domain swap beta strand [polypeptide binding]; other site 1338518008778 regulatory protein interface [polypeptide binding]; other site 1338518008779 active site 1338518008780 regulatory phosphorylation site [posttranslational modification]; other site 1338518008781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1338518008782 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1338518008783 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1338518008784 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1338518008785 phosphate binding site [ion binding]; other site 1338518008786 putative substrate binding pocket [chemical binding]; other site 1338518008787 dimer interface [polypeptide binding]; other site 1338518008788 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1338518008789 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1338518008790 putative active site [active] 1338518008791 nucleotide binding site [chemical binding]; other site 1338518008792 nudix motif; other site 1338518008793 putative metal binding site [ion binding]; other site 1338518008794 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1338518008795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1338518008796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518008797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1338518008798 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 1338518008799 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1338518008800 NlpC/P60 family; Region: NLPC_P60; pfam00877 1338518008801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518008802 binding surface 1338518008803 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1338518008804 TPR motif; other site 1338518008805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518008806 TPR motif; other site 1338518008807 binding surface 1338518008808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518008809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518008810 dimer interface [polypeptide binding]; other site 1338518008811 phosphorylation site [posttranslational modification] 1338518008812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518008813 ATP binding site [chemical binding]; other site 1338518008814 Mg2+ binding site [ion binding]; other site 1338518008815 G-X-G motif; other site 1338518008816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518008817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518008818 active site 1338518008819 phosphorylation site [posttranslational modification] 1338518008820 intermolecular recognition site; other site 1338518008821 dimerization interface [polypeptide binding]; other site 1338518008822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518008823 DNA binding site [nucleotide binding] 1338518008824 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1338518008825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1338518008826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518008827 Walker A/P-loop; other site 1338518008828 ATP binding site [chemical binding]; other site 1338518008829 Q-loop/lid; other site 1338518008830 ABC transporter signature motif; other site 1338518008831 Walker B; other site 1338518008832 D-loop; other site 1338518008833 H-loop/switch region; other site 1338518008834 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1338518008835 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1338518008836 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1338518008837 metal binding site [ion binding]; metal-binding site 1338518008838 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1338518008839 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1338518008840 substrate binding site [chemical binding]; other site 1338518008841 glutamase interaction surface [polypeptide binding]; other site 1338518008842 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1338518008843 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1338518008844 catalytic residues [active] 1338518008845 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1338518008846 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1338518008847 putative active site [active] 1338518008848 oxyanion strand; other site 1338518008849 catalytic triad [active] 1338518008850 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1338518008851 putative active site pocket [active] 1338518008852 4-fold oligomerization interface [polypeptide binding]; other site 1338518008853 metal binding residues [ion binding]; metal-binding site 1338518008854 3-fold/trimer interface [polypeptide binding]; other site 1338518008855 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1338518008856 histidinol dehydrogenase; Region: hisD; TIGR00069 1338518008857 NAD binding site [chemical binding]; other site 1338518008858 dimerization interface [polypeptide binding]; other site 1338518008859 product binding site; other site 1338518008860 substrate binding site [chemical binding]; other site 1338518008861 zinc binding site [ion binding]; other site 1338518008862 catalytic residues [active] 1338518008863 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1338518008864 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1338518008865 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1338518008866 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1338518008867 dimer interface [polypeptide binding]; other site 1338518008868 motif 1; other site 1338518008869 active site 1338518008870 motif 2; other site 1338518008871 motif 3; other site 1338518008872 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1338518008873 putative active site [active] 1338518008874 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1338518008875 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1338518008876 trimer interface [polypeptide binding]; other site 1338518008877 active site 1338518008878 substrate binding site [chemical binding]; other site 1338518008879 CoA binding site [chemical binding]; other site 1338518008880 pyrophosphatase PpaX; Provisional; Region: PRK13288 1338518008881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1338518008882 motif I; other site 1338518008883 active site 1338518008884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518008885 motif II; other site 1338518008886 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1338518008887 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1338518008888 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1338518008889 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1338518008890 Hpr binding site; other site 1338518008891 active site 1338518008892 homohexamer subunit interaction site [polypeptide binding]; other site 1338518008893 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1338518008894 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1338518008895 active site 1338518008896 dimer interface [polypeptide binding]; other site 1338518008897 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1338518008898 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1338518008899 active site 1338518008900 trimer interface [polypeptide binding]; other site 1338518008901 allosteric site; other site 1338518008902 active site lid [active] 1338518008903 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1338518008904 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1338518008905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518008906 DNA-binding site [nucleotide binding]; DNA binding site 1338518008907 UTRA domain; Region: UTRA; pfam07702 1338518008908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518008909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518008910 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1338518008911 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1338518008912 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1338518008913 putative active site [active] 1338518008914 putative metal binding site [ion binding]; other site 1338518008915 PspC domain; Region: PspC; pfam04024 1338518008916 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1338518008917 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1338518008918 excinuclease ABC subunit B; Provisional; Region: PRK05298 1338518008919 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518008920 ATP binding site [chemical binding]; other site 1338518008921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518008922 nucleotide binding region [chemical binding]; other site 1338518008923 ATP-binding site [chemical binding]; other site 1338518008924 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1338518008925 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1338518008926 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1338518008927 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1338518008928 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1338518008929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518008930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518008931 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1338518008932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518008933 putative substrate translocation pore; other site 1338518008934 Thioesterase domain; Region: Thioesterase; pfam00975 1338518008935 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 1338518008936 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1338518008937 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1338518008938 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1338518008939 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1338518008940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518008941 Walker A/P-loop; other site 1338518008942 ATP binding site [chemical binding]; other site 1338518008943 Q-loop/lid; other site 1338518008944 ABC transporter signature motif; other site 1338518008945 Walker B; other site 1338518008946 D-loop; other site 1338518008947 H-loop/switch region; other site 1338518008948 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1338518008949 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1338518008950 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1338518008951 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518008952 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518008953 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1338518008954 peptide chain release factor 2; Provisional; Region: PRK06746 1338518008955 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1338518008956 RF-1 domain; Region: RF-1; pfam00472 1338518008957 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1338518008958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1338518008959 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1338518008960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1338518008961 nucleotide binding region [chemical binding]; other site 1338518008962 ATP-binding site [chemical binding]; other site 1338518008963 SEC-C motif; Region: SEC-C; pfam02810 1338518008964 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1338518008965 30S subunit binding site; other site 1338518008966 Flagellar protein FliT; Region: FliT; pfam05400 1338518008967 flagellar protein FliS; Validated; Region: fliS; PRK05685 1338518008968 flagellar capping protein; Validated; Region: fliD; PRK07737 1338518008969 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1338518008970 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1338518008971 flagellin; Provisional; Region: PRK12804 1338518008972 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1338518008973 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1338518008974 carbon storage regulator; Provisional; Region: PRK01712 1338518008975 flagellar assembly protein FliW; Provisional; Region: PRK13285 1338518008976 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1338518008977 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1338518008978 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1338518008979 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1338518008980 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1338518008981 FlgN protein; Region: FlgN; pfam05130 1338518008982 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1338518008983 flagellar operon protein TIGR03826; Region: YvyF 1338518008984 Late competence development protein ComFB; Region: ComFB; pfam10719 1338518008985 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1338518008986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518008987 ATP binding site [chemical binding]; other site 1338518008988 putative Mg++ binding site [ion binding]; other site 1338518008989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518008990 nucleotide binding region [chemical binding]; other site 1338518008991 ATP-binding site [chemical binding]; other site 1338518008992 EDD domain protein, DegV family; Region: DegV; TIGR00762 1338518008993 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1338518008994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518008995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518008996 active site 1338518008997 phosphorylation site [posttranslational modification] 1338518008998 intermolecular recognition site; other site 1338518008999 dimerization interface [polypeptide binding]; other site 1338518009000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518009001 DNA binding residues [nucleotide binding] 1338518009002 dimerization interface [polypeptide binding]; other site 1338518009003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1338518009004 Histidine kinase; Region: HisKA_3; pfam07730 1338518009005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518009006 ATP binding site [chemical binding]; other site 1338518009007 Mg2+ binding site [ion binding]; other site 1338518009008 G-X-G motif; other site 1338518009009 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1338518009010 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1338518009011 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1338518009012 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1338518009013 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1338518009014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1338518009015 putative homodimer interface [polypeptide binding]; other site 1338518009016 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1338518009017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1338518009018 active site 1338518009019 O-Antigen ligase; Region: Wzy_C; pfam04932 1338518009020 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1338518009021 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1338518009022 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1338518009023 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1338518009024 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1338518009025 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1338518009026 colanic acid exporter; Provisional; Region: PRK10459 1338518009027 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1338518009028 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1338518009029 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1338518009030 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1338518009031 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1338518009032 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1338518009033 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1338518009034 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1338518009035 active site 1338518009036 metal binding site [ion binding]; metal-binding site 1338518009037 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1338518009038 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1338518009039 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1338518009040 Stage II sporulation protein; Region: SpoIID; pfam08486 1338518009041 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1338518009042 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1338518009043 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1338518009044 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1338518009045 active site 1338518009046 homodimer interface [polypeptide binding]; other site 1338518009047 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1338518009048 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1338518009049 active site 1338518009050 tetramer interface; other site 1338518009051 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1338518009052 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1338518009053 Walker A/P-loop; other site 1338518009054 ATP binding site [chemical binding]; other site 1338518009055 Q-loop/lid; other site 1338518009056 ABC transporter signature motif; other site 1338518009057 Walker B; other site 1338518009058 D-loop; other site 1338518009059 H-loop/switch region; other site 1338518009060 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1338518009061 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1338518009062 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1338518009063 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1338518009064 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1338518009065 active site 1338518009066 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1338518009067 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1338518009068 active site 1338518009069 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1338518009070 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1338518009071 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1338518009072 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1338518009073 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1338518009074 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1338518009075 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1338518009076 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1338518009077 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1338518009078 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1338518009079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009080 putative substrate translocation pore; other site 1338518009081 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1338518009082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518009083 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1338518009084 active site 1338518009085 motif I; other site 1338518009086 motif II; other site 1338518009087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518009088 Septum formation initiator; Region: DivIC; cl17659 1338518009089 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1338518009090 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1338518009091 putative active site [active] 1338518009092 putative metal binding site [ion binding]; other site 1338518009093 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1338518009094 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1338518009095 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1338518009096 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1338518009097 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1338518009098 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1338518009099 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518009100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518009101 DNA binding site [nucleotide binding] 1338518009102 domain linker motif; other site 1338518009103 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1338518009104 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1338518009105 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1338518009106 substrate binding site [chemical binding]; other site 1338518009107 dimer interface [polypeptide binding]; other site 1338518009108 ATP binding site [chemical binding]; other site 1338518009109 D-ribose pyranase; Provisional; Region: PRK11797 1338518009110 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1338518009111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518009112 Walker A/P-loop; other site 1338518009113 ATP binding site [chemical binding]; other site 1338518009114 Q-loop/lid; other site 1338518009115 ABC transporter signature motif; other site 1338518009116 Walker B; other site 1338518009117 D-loop; other site 1338518009118 H-loop/switch region; other site 1338518009119 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1338518009120 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1338518009121 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1338518009122 TM-ABC transporter signature motif; other site 1338518009123 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1338518009124 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1338518009125 ligand binding site [chemical binding]; other site 1338518009126 dimerization interface [polypeptide binding]; other site 1338518009127 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1338518009128 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1338518009129 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1338518009130 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1338518009131 acetolactate synthase; Reviewed; Region: PRK08617 1338518009132 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1338518009133 PYR/PP interface [polypeptide binding]; other site 1338518009134 dimer interface [polypeptide binding]; other site 1338518009135 TPP binding site [chemical binding]; other site 1338518009136 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1338518009137 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1338518009138 TPP-binding site [chemical binding]; other site 1338518009139 dimer interface [polypeptide binding]; other site 1338518009140 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1338518009141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518009142 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1338518009143 putative dimerization interface [polypeptide binding]; other site 1338518009144 putative substrate binding pocket [chemical binding]; other site 1338518009145 CotH protein; Region: CotH; pfam08757 1338518009146 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1338518009147 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1338518009148 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1338518009149 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1338518009150 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1338518009151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518009152 putative DNA binding site [nucleotide binding]; other site 1338518009153 putative Zn2+ binding site [ion binding]; other site 1338518009154 AsnC family; Region: AsnC_trans_reg; pfam01037 1338518009155 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1338518009156 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1338518009157 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1338518009158 Active_site [active] 1338518009159 LXG domain of WXG superfamily; Region: LXG; pfam04740 1338518009160 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1338518009161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1338518009162 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1338518009163 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1338518009164 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1338518009165 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1338518009166 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1338518009167 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1338518009168 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1338518009169 Nucleotide binding site [chemical binding]; other site 1338518009170 DTAP/Switch II; other site 1338518009171 Switch I; other site 1338518009172 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1338518009173 Chain length determinant protein; Region: Wzz; cl15801 1338518009174 SWIM zinc finger; Region: SWIM; pfam04434 1338518009175 SNF2 Helicase protein; Region: DUF3670; pfam12419 1338518009176 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1338518009177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518009178 ATP binding site [chemical binding]; other site 1338518009179 putative Mg++ binding site [ion binding]; other site 1338518009180 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1338518009181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518009182 nucleotide binding region [chemical binding]; other site 1338518009183 ATP-binding site [chemical binding]; other site 1338518009184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518009185 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1338518009186 active site 1338518009187 motif I; other site 1338518009188 motif II; other site 1338518009189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518009190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1338518009191 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1338518009192 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1338518009193 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1338518009194 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1338518009195 dimer interface [polypeptide binding]; other site 1338518009196 ssDNA binding site [nucleotide binding]; other site 1338518009197 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1338518009198 YwpF-like protein; Region: YwpF; pfam14183 1338518009199 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1338518009200 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1338518009201 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1338518009202 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518009203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518009204 binding surface 1338518009205 TPR motif; other site 1338518009206 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518009207 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1338518009208 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1338518009209 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1338518009210 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1338518009211 MreB and similar proteins; Region: MreB_like; cd10225 1338518009212 nucleotide binding site [chemical binding]; other site 1338518009213 Mg binding site [ion binding]; other site 1338518009214 putative protofilament interaction site [polypeptide binding]; other site 1338518009215 RodZ interaction site [polypeptide binding]; other site 1338518009216 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1338518009217 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518009218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518009219 putative Zn2+ binding site [ion binding]; other site 1338518009220 putative DNA binding site [nucleotide binding]; other site 1338518009221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009222 putative substrate translocation pore; other site 1338518009223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518009224 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1338518009225 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1338518009226 Na binding site [ion binding]; other site 1338518009227 putative substrate binding site [chemical binding]; other site 1338518009228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518009230 putative substrate translocation pore; other site 1338518009231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009232 Isochorismatase family; Region: Isochorismatase; pfam00857 1338518009233 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1338518009234 catalytic triad [active] 1338518009235 conserved cis-peptide bond; other site 1338518009236 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1338518009237 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1338518009238 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1338518009239 cell division protein FtsW; Region: ftsW; TIGR02614 1338518009240 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1338518009241 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1338518009242 active site 1338518009243 VanZ like family; Region: VanZ; pfam04892 1338518009244 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1338518009245 Peptidase family M23; Region: Peptidase_M23; pfam01551 1338518009246 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1338518009247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518009248 Coenzyme A binding pocket [chemical binding]; other site 1338518009249 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1338518009250 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1338518009251 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1338518009252 putative active site [active] 1338518009253 catalytic site [active] 1338518009254 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1338518009255 putative active site [active] 1338518009256 catalytic site [active] 1338518009257 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1338518009258 Predicted transcriptional regulator [Transcription]; Region: COG1959 1338518009259 Transcriptional regulator; Region: Rrf2; pfam02082 1338518009260 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1338518009261 gamma-beta subunit interface [polypeptide binding]; other site 1338518009262 alpha-beta subunit interface [polypeptide binding]; other site 1338518009263 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1338518009264 alpha-gamma subunit interface [polypeptide binding]; other site 1338518009265 beta-gamma subunit interface [polypeptide binding]; other site 1338518009266 CsbD-like; Region: CsbD; pfam05532 1338518009267 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518009268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518009269 binding surface 1338518009270 TPR motif; other site 1338518009271 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1338518009272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1338518009273 FeS/SAM binding site; other site 1338518009274 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1338518009275 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1338518009276 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1338518009277 metal ion-dependent adhesion site (MIDAS); other site 1338518009278 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1338518009279 metal ion-dependent adhesion site (MIDAS); other site 1338518009280 Stage II sporulation protein; Region: SpoIID; pfam08486 1338518009281 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1338518009282 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1338518009283 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1338518009284 hinge; other site 1338518009285 active site 1338518009286 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1338518009287 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1338518009288 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1338518009289 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1338518009290 gamma subunit interface [polypeptide binding]; other site 1338518009291 epsilon subunit interface [polypeptide binding]; other site 1338518009292 LBP interface [polypeptide binding]; other site 1338518009293 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1338518009294 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1338518009295 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1338518009296 alpha subunit interaction interface [polypeptide binding]; other site 1338518009297 Walker A motif; other site 1338518009298 ATP binding site [chemical binding]; other site 1338518009299 Walker B motif; other site 1338518009300 inhibitor binding site; inhibition site 1338518009301 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1338518009302 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1338518009303 core domain interface [polypeptide binding]; other site 1338518009304 delta subunit interface [polypeptide binding]; other site 1338518009305 epsilon subunit interface [polypeptide binding]; other site 1338518009306 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1338518009307 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1338518009308 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1338518009309 beta subunit interaction interface [polypeptide binding]; other site 1338518009310 Walker A motif; other site 1338518009311 ATP binding site [chemical binding]; other site 1338518009312 Walker B motif; other site 1338518009313 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1338518009314 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1338518009315 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1338518009316 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1338518009317 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1338518009318 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1338518009319 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1338518009320 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1338518009321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1338518009322 active site 1338518009323 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1338518009324 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1338518009325 dimer interface [polypeptide binding]; other site 1338518009326 active site 1338518009327 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1338518009328 folate binding site [chemical binding]; other site 1338518009329 hypothetical protein; Provisional; Region: PRK13690 1338518009330 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1338518009331 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1338518009332 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1338518009333 active site 1338518009334 Predicted membrane protein [Function unknown]; Region: COG1971 1338518009335 Domain of unknown function DUF; Region: DUF204; pfam02659 1338518009336 Domain of unknown function DUF; Region: DUF204; pfam02659 1338518009337 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1338518009338 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1338518009339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1338518009340 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1338518009341 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1338518009342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518009343 S-adenosylmethionine binding site [chemical binding]; other site 1338518009344 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1338518009345 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1338518009346 RF-1 domain; Region: RF-1; pfam00472 1338518009347 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1338518009348 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518009349 putative metal binding site [ion binding]; other site 1338518009350 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1338518009351 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1338518009352 DNA binding residues [nucleotide binding] 1338518009353 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1338518009354 malate dehydrogenase; Provisional; Region: PRK13529 1338518009355 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1338518009356 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1338518009357 NAD(P) binding site [chemical binding]; other site 1338518009358 thymidine kinase; Provisional; Region: PRK04296 1338518009359 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1338518009360 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1338518009361 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1338518009362 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1338518009363 RNA binding site [nucleotide binding]; other site 1338518009364 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1338518009365 multimer interface [polypeptide binding]; other site 1338518009366 Walker A motif; other site 1338518009367 ATP binding site [chemical binding]; other site 1338518009368 Walker B motif; other site 1338518009369 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1338518009370 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1338518009371 putative active site [active] 1338518009372 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1338518009373 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1338518009374 hinge; other site 1338518009375 active site 1338518009376 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1338518009377 active site 1338518009378 intersubunit interactions; other site 1338518009379 catalytic residue [active] 1338518009380 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1338518009381 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1338518009382 intersubunit interface [polypeptide binding]; other site 1338518009383 active site 1338518009384 zinc binding site [ion binding]; other site 1338518009385 Na+ binding site [ion binding]; other site 1338518009386 Response regulator receiver domain; Region: Response_reg; pfam00072 1338518009387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518009388 active site 1338518009389 phosphorylation site [posttranslational modification] 1338518009390 intermolecular recognition site; other site 1338518009391 dimerization interface [polypeptide binding]; other site 1338518009392 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1338518009393 CTP synthetase; Validated; Region: pyrG; PRK05380 1338518009394 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1338518009395 Catalytic site [active] 1338518009396 active site 1338518009397 UTP binding site [chemical binding]; other site 1338518009398 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1338518009399 active site 1338518009400 putative oxyanion hole; other site 1338518009401 catalytic triad [active] 1338518009402 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1338518009403 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1338518009404 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1338518009405 Cysteine-rich domain; Region: CCG; pfam02754 1338518009406 Cysteine-rich domain; Region: CCG; pfam02754 1338518009407 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1338518009408 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1338518009409 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1338518009410 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1338518009411 Walker A/P-loop; other site 1338518009412 ATP binding site [chemical binding]; other site 1338518009413 Q-loop/lid; other site 1338518009414 ABC transporter signature motif; other site 1338518009415 Walker B; other site 1338518009416 D-loop; other site 1338518009417 H-loop/switch region; other site 1338518009418 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1338518009419 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518009420 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1338518009421 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1338518009422 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1338518009423 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1338518009424 [4Fe-4S] binding site [ion binding]; other site 1338518009425 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1338518009426 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1338518009427 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1338518009428 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1338518009429 molybdopterin cofactor binding site; other site 1338518009430 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1338518009431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1338518009432 ligand binding site [chemical binding]; other site 1338518009433 flexible hinge region; other site 1338518009434 YwiC-like protein; Region: YwiC; pfam14256 1338518009435 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1338518009436 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1338518009437 ligand binding site [chemical binding]; other site 1338518009438 flexible hinge region; other site 1338518009439 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1338518009440 putative switch regulator; other site 1338518009441 non-specific DNA interactions [nucleotide binding]; other site 1338518009442 DNA binding site [nucleotide binding] 1338518009443 sequence specific DNA binding site [nucleotide binding]; other site 1338518009444 putative cAMP binding site [chemical binding]; other site 1338518009445 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1338518009446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009447 putative substrate translocation pore; other site 1338518009448 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1338518009449 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1338518009450 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1338518009451 active site 1338518009452 HIGH motif; other site 1338518009453 KMSK motif region; other site 1338518009454 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1338518009455 tRNA binding surface [nucleotide binding]; other site 1338518009456 anticodon binding site; other site 1338518009457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1338518009458 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm:putative membrane component 1338518009459 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1338518009460 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1338518009461 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1338518009462 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1338518009463 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518009464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1338518009465 binding surface 1338518009466 TPR motif; other site 1338518009467 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518009468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1338518009469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1338518009470 non-specific DNA binding site [nucleotide binding]; other site 1338518009471 salt bridge; other site 1338518009472 sequence-specific DNA binding site [nucleotide binding]; other site 1338518009473 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1338518009474 DNA binding residues [nucleotide binding] 1338518009475 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1338518009476 dimerization interface [polypeptide binding]; other site 1338518009477 agmatinase; Region: agmatinase; TIGR01230 1338518009478 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1338518009479 putative active site [active] 1338518009480 Mn binding site [ion binding]; other site 1338518009481 spermidine synthase; Provisional; Region: PRK00811 1338518009482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1338518009483 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1338518009484 Transglycosylase; Region: Transgly; pfam00912 1338518009485 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1338518009486 YwhD family; Region: YwhD; pfam08741 1338518009487 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1338518009488 Peptidase family M50; Region: Peptidase_M50; pfam02163 1338518009489 active site 1338518009490 putative substrate binding region [chemical binding]; other site 1338518009491 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1338518009492 active site 1 [active] 1338518009493 dimer interface [polypeptide binding]; other site 1338518009494 hexamer interface [polypeptide binding]; other site 1338518009495 active site 2 [active] 1338518009496 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518009497 dimerization interface [polypeptide binding]; other site 1338518009498 putative DNA binding site [nucleotide binding]; other site 1338518009499 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518009500 putative Zn2+ binding site [ion binding]; other site 1338518009501 amino acid transporter; Region: 2A0306; TIGR00909 1338518009502 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1338518009503 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1338518009504 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1338518009505 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518009506 Zn2+ binding site [ion binding]; other site 1338518009507 Mg2+ binding site [ion binding]; other site 1338518009508 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1338518009509 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1338518009510 Predicted transcriptional regulators [Transcription]; Region: COG1695 1338518009511 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1338518009512 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1338518009513 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1338518009514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1338518009515 Walker A/P-loop; other site 1338518009516 ATP binding site [chemical binding]; other site 1338518009517 Q-loop/lid; other site 1338518009518 ABC transporter signature motif; other site 1338518009519 Walker B; other site 1338518009520 D-loop; other site 1338518009521 H-loop/switch region; other site 1338518009522 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1338518009523 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1338518009524 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1338518009525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518009526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518009527 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1338518009528 putative dimerization interface [polypeptide binding]; other site 1338518009529 Predicted membrane protein [Function unknown]; Region: COG2855 1338518009530 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1338518009531 putative heme peroxidase; Provisional; Region: PRK12276 1338518009532 transaminase; Reviewed; Region: PRK08068 1338518009533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518009534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518009535 homodimer interface [polypeptide binding]; other site 1338518009536 catalytic residue [active] 1338518009537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009538 H+ Antiporter protein; Region: 2A0121; TIGR00900 1338518009539 putative substrate translocation pore; other site 1338518009540 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1338518009541 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1338518009542 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1338518009543 classical (c) SDRs; Region: SDR_c; cd05233 1338518009544 NAD(P) binding site [chemical binding]; other site 1338518009545 active site 1338518009546 Cupin domain; Region: Cupin_2; pfam07883 1338518009547 Cupin domain; Region: Cupin_2; pfam07883 1338518009548 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1338518009549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009550 putative substrate translocation pore; other site 1338518009551 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1338518009552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009553 putative substrate translocation pore; other site 1338518009554 S-methylmethionine transporter; Provisional; Region: PRK11387 1338518009555 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1338518009556 putative metal binding site [ion binding]; other site 1338518009557 putative dimer interface [polypeptide binding]; other site 1338518009558 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1338518009559 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1338518009560 Glutamate binding site [chemical binding]; other site 1338518009561 homodimer interface [polypeptide binding]; other site 1338518009562 NAD binding site [chemical binding]; other site 1338518009563 catalytic residues [active] 1338518009564 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1338518009565 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1338518009566 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1338518009567 NAD(P) binding site [chemical binding]; other site 1338518009568 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1338518009569 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1338518009570 NADP binding site [chemical binding]; other site 1338518009571 active site 1338518009572 putative substrate binding site [chemical binding]; other site 1338518009573 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1338518009574 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1338518009575 NAD binding site [chemical binding]; other site 1338518009576 substrate binding site [chemical binding]; other site 1338518009577 homodimer interface [polypeptide binding]; other site 1338518009578 active site 1338518009579 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1338518009580 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1338518009581 substrate binding site; other site 1338518009582 tetramer interface; other site 1338518009583 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1338518009584 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1338518009585 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1338518009586 NeuB family; Region: NeuB; pfam03102 1338518009587 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1338518009588 NeuB binding interface [polypeptide binding]; other site 1338518009589 putative substrate binding site [chemical binding]; other site 1338518009590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1338518009591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518009592 Coenzyme A binding pocket [chemical binding]; other site 1338518009593 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1338518009594 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1338518009595 inhibitor-cofactor binding pocket; inhibition site 1338518009596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518009597 catalytic residue [active] 1338518009598 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1338518009599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1338518009600 active site 1338518009601 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1338518009602 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1338518009603 Permease family; Region: Xan_ur_permease; pfam00860 1338518009604 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1338518009605 ligand binding site [chemical binding]; other site 1338518009606 active site 1338518009607 UGI interface [polypeptide binding]; other site 1338518009608 catalytic site [active] 1338518009609 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1338518009610 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1338518009611 active site 1338518009612 Predicted transcriptional regulators [Transcription]; Region: COG1695 1338518009613 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1338518009614 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1338518009615 dimer interface [polypeptide binding]; other site 1338518009616 substrate binding site [chemical binding]; other site 1338518009617 ATP binding site [chemical binding]; other site 1338518009618 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1338518009619 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1338518009620 substrate binding [chemical binding]; other site 1338518009621 active site 1338518009622 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1338518009623 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1338518009624 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1338518009625 active site turn [active] 1338518009626 phosphorylation site [posttranslational modification] 1338518009627 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1338518009628 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1338518009629 CAT RNA binding domain; Region: CAT_RBD; smart01061 1338518009630 PRD domain; Region: PRD; pfam00874 1338518009631 PRD domain; Region: PRD; pfam00874 1338518009632 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1338518009633 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1338518009634 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1338518009635 putative active site [active] 1338518009636 catalytic triad [active] 1338518009637 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1338518009638 PA/protease domain interface [polypeptide binding]; other site 1338518009639 putative integrin binding motif; other site 1338518009640 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1338518009641 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1338518009642 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1338518009643 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1338518009644 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1338518009645 dimer interface [polypeptide binding]; other site 1338518009646 FMN binding site [chemical binding]; other site 1338518009647 NADPH bind site [chemical binding]; other site 1338518009648 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1338518009649 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1338518009650 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1338518009651 Subunit I/III interface [polypeptide binding]; other site 1338518009652 Subunit III/IV interface [polypeptide binding]; other site 1338518009653 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1338518009654 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1338518009655 D-pathway; other site 1338518009656 Putative ubiquinol binding site [chemical binding]; other site 1338518009657 Low-spin heme (heme b) binding site [chemical binding]; other site 1338518009658 Putative water exit pathway; other site 1338518009659 Binuclear center (heme o3/CuB) [ion binding]; other site 1338518009660 K-pathway; other site 1338518009661 Putative proton exit pathway; other site 1338518009662 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1338518009663 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1338518009664 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1338518009665 galactokinase; Provisional; Region: PRK05322 1338518009666 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1338518009667 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1338518009668 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1338518009669 Predicted membrane protein [Function unknown]; Region: COG2246 1338518009670 GtrA-like protein; Region: GtrA; pfam04138 1338518009671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518009672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518009673 Anti-repressor SinI; Region: SinI; pfam08671 1338518009674 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1338518009675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518009676 S-adenosylmethionine binding site [chemical binding]; other site 1338518009677 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1338518009678 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1338518009679 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1338518009680 catalytic residues [active] 1338518009681 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1338518009682 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1338518009683 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:12354229, 16672620, 16987175; Product type t:transporter 1338518009684 Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:12354229, 16672620, 16987175; Product type t:transporter 1338518009685 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1338518009686 thiamine phosphate binding site [chemical binding]; other site 1338518009687 active site 1338518009688 pyrophosphate binding site [ion binding]; other site 1338518009689 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1338518009690 substrate binding site [chemical binding]; other site 1338518009691 multimerization interface [polypeptide binding]; other site 1338518009692 ATP binding site [chemical binding]; other site 1338518009693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518009694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518009695 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1338518009696 putative dimerization interface [polypeptide binding]; other site 1338518009697 TIGR00659 family protein; Region: TIGR00659 1338518009698 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1338518009699 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1338518009700 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1338518009701 putative RNA binding site [nucleotide binding]; other site 1338518009702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518009703 S-adenosylmethionine binding site [chemical binding]; other site 1338518009704 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518009705 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1338518009706 active site 1338518009707 metal binding site [ion binding]; metal-binding site 1338518009708 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1338518009709 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1338518009710 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1338518009711 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1338518009712 Ligand binding site; other site 1338518009713 metal-binding site 1338518009714 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1338518009715 synthetase active site [active] 1338518009716 NTP binding site [chemical binding]; other site 1338518009717 metal binding site [ion binding]; metal-binding site 1338518009718 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1338518009719 UbiA prenyltransferase family; Region: UbiA; pfam01040 1338518009720 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1338518009721 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1338518009722 acyl-activating enzyme (AAE) consensus motif; other site 1338518009723 AMP binding site [chemical binding]; other site 1338518009724 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1338518009725 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1338518009726 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1338518009727 DltD N-terminal region; Region: DltD_N; pfam04915 1338518009728 DltD central region; Region: DltD_M; pfam04918 1338518009729 DltD C-terminal region; Region: DltD_C; pfam04914 1338518009730 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1338518009731 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1338518009732 homodimer interface [polypeptide binding]; other site 1338518009733 substrate-cofactor binding pocket; other site 1338518009734 catalytic residue [active] 1338518009735 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1338518009736 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1338518009737 NAD binding site [chemical binding]; other site 1338518009738 sugar binding site [chemical binding]; other site 1338518009739 divalent metal binding site [ion binding]; other site 1338518009740 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1338518009741 dimer interface [polypeptide binding]; other site 1338518009742 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1338518009743 methionine cluster; other site 1338518009744 active site 1338518009745 phosphorylation site [posttranslational modification] 1338518009746 metal binding site [ion binding]; metal-binding site 1338518009747 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1338518009748 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1338518009749 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1338518009750 active site 1338518009751 P-loop; other site 1338518009752 phosphorylation site [posttranslational modification] 1338518009753 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1338518009754 HTH domain; Region: HTH_11; pfam08279 1338518009755 Mga helix-turn-helix domain; Region: Mga; pfam05043 1338518009756 PRD domain; Region: PRD; pfam00874 1338518009757 PRD domain; Region: PRD; pfam00874 1338518009758 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1338518009759 active site 1338518009760 P-loop; other site 1338518009761 phosphorylation site [posttranslational modification] 1338518009762 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1338518009763 active site 1338518009764 phosphorylation site [posttranslational modification] 1338518009765 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1338518009766 active site 1338518009767 DNA binding site [nucleotide binding] 1338518009768 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1338518009769 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518009770 ABC-ATPase subunit interface; other site 1338518009771 dimer interface [polypeptide binding]; other site 1338518009772 putative PBP binding regions; other site 1338518009773 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1338518009774 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1338518009775 ABC-ATPase subunit interface; other site 1338518009776 dimer interface [polypeptide binding]; other site 1338518009777 putative PBP binding regions; other site 1338518009778 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1338518009779 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1338518009780 intersubunit interface [polypeptide binding]; other site 1338518009781 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518009782 dimerization interface [polypeptide binding]; other site 1338518009783 putative DNA binding site [nucleotide binding]; other site 1338518009784 putative Zn2+ binding site [ion binding]; other site 1338518009785 arsenical pump membrane protein; Provisional; Region: PRK15445 1338518009786 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1338518009787 transmembrane helices; other site 1338518009788 Evidence 3:Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId:18177310; Product type t:transporter 1338518009789 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1338518009790 active site 1338518009791 methionine cluster; other site 1338518009792 phosphorylation site [posttranslational modification] 1338518009793 metal binding site [ion binding]; metal-binding site 1338518009794 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1338518009795 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1338518009796 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1338518009797 beta-galactosidase; Region: BGL; TIGR03356 1338518009798 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1338518009799 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1338518009800 nucleotide binding site [chemical binding]; other site 1338518009801 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1338518009802 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1338518009803 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1338518009804 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1338518009805 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1338518009806 active site 1338518009807 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1338518009808 putative substrate binding site [chemical binding]; other site 1338518009809 putative ATP binding site [chemical binding]; other site 1338518009810 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1338518009811 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1338518009812 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1338518009813 Walker A/P-loop; other site 1338518009814 ATP binding site [chemical binding]; other site 1338518009815 Q-loop/lid; other site 1338518009816 ABC transporter signature motif; other site 1338518009817 Walker B; other site 1338518009818 D-loop; other site 1338518009819 H-loop/switch region; other site 1338518009820 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1338518009821 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1338518009822 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1338518009823 ATP binding site [chemical binding]; other site 1338518009824 Q-loop/lid; other site 1338518009825 ABC transporter signature motif; other site 1338518009826 Walker B; other site 1338518009827 D-loop; other site 1338518009828 H-loop/switch region; other site 1338518009829 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1338518009830 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1338518009831 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1338518009832 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1338518009833 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1338518009834 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1338518009835 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1338518009836 putative active site [active] 1338518009837 putative metal binding site [ion binding]; other site 1338518009838 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1338518009839 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1338518009840 Walker A/P-loop; other site 1338518009841 ATP binding site [chemical binding]; other site 1338518009842 Q-loop/lid; other site 1338518009843 ABC transporter signature motif; other site 1338518009844 Walker B; other site 1338518009845 D-loop; other site 1338518009846 H-loop/switch region; other site 1338518009847 TOBE domain; Region: TOBE; pfam03459 1338518009848 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1338518009849 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1338518009850 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1338518009851 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518009852 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1338518009853 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1338518009854 UDP-glucose 4-epimerase; Region: PLN02240 1338518009855 NAD binding site [chemical binding]; other site 1338518009856 homodimer interface [polypeptide binding]; other site 1338518009857 active site 1338518009858 substrate binding site [chemical binding]; other site 1338518009859 peptidase T; Region: peptidase-T; TIGR01882 1338518009860 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1338518009861 metal binding site [ion binding]; metal-binding site 1338518009862 dimer interface [polypeptide binding]; other site 1338518009863 Tubby C 2; Region: Tub_2; cl02043 1338518009864 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1338518009865 substrate binding site [chemical binding]; other site 1338518009866 THF binding site; other site 1338518009867 zinc-binding site [ion binding]; other site 1338518009868 nucleoside transporter; Region: nupC; TIGR00804 1338518009869 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1338518009870 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1338518009871 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1338518009872 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1338518009873 hydroperoxidase II; Provisional; Region: katE; PRK11249 1338518009874 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1338518009875 tetramer interface [polypeptide binding]; other site 1338518009876 heme binding pocket [chemical binding]; other site 1338518009877 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1338518009878 domain interactions; other site 1338518009879 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1338518009880 Citrate transporter; Region: CitMHS; pfam03600 1338518009881 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1338518009882 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1338518009883 active site 1338518009884 active site 1338518009885 catalytic residues [active] 1338518009886 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1338518009887 CAT RNA binding domain; Region: CAT_RBD; smart01061 1338518009888 PRD domain; Region: PRD; pfam00874 1338518009889 PRD domain; Region: PRD; pfam00874 1338518009890 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1338518009891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518009892 putative substrate translocation pore; other site 1338518009893 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1338518009894 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1338518009895 ATP binding site [chemical binding]; other site 1338518009896 Mg++ binding site [ion binding]; other site 1338518009897 motif III; other site 1338518009898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518009899 nucleotide binding region [chemical binding]; other site 1338518009900 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1338518009901 RNA binding site [nucleotide binding]; other site 1338518009902 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1338518009903 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1338518009904 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1338518009905 YxiJ-like protein; Region: YxiJ; pfam14176 1338518009906 RHS Repeat; Region: RHS_repeat; pfam05593 1338518009907 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1338518009908 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1338518009909 RHS Repeat; Region: RHS_repeat; pfam05593 1338518009910 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1338518009911 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1338518009912 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1338518009913 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1338518009914 Amb_all domain; Region: Amb_all; smart00656 1338518009915 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1338518009916 EamA-like transporter family; Region: EamA; pfam00892 1338518009917 EamA-like transporter family; Region: EamA; pfam00892 1338518009918 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1338518009919 Ligand Binding Site [chemical binding]; other site 1338518009920 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1338518009921 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1338518009922 active site turn [active] 1338518009923 phosphorylation site [posttranslational modification] 1338518009924 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1338518009925 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1338518009926 HPr interaction site; other site 1338518009927 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1338518009928 active site 1338518009929 phosphorylation site [posttranslational modification] 1338518009930 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 1338518009931 PLD-like domain; Region: PLDc_2; pfam13091 1338518009932 putative homodimer interface [polypeptide binding]; other site 1338518009933 putative active site [active] 1338518009934 catalytic site [active] 1338518009935 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1338518009936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1338518009937 ATP binding site [chemical binding]; other site 1338518009938 putative Mg++ binding site [ion binding]; other site 1338518009939 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1338518009940 nucleotide binding region [chemical binding]; other site 1338518009941 ATP-binding site [chemical binding]; other site 1338518009942 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1338518009943 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1338518009944 active site 1338518009945 8-oxo-dGMP binding site [chemical binding]; other site 1338518009946 nudix motif; other site 1338518009947 metal binding site [ion binding]; metal-binding site 1338518009948 AAA domain; Region: AAA_11; pfam13086 1338518009949 Part of AAA domain; Region: AAA_19; pfam13245 1338518009950 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1338518009951 AAA domain; Region: AAA_12; pfam13087 1338518009952 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1338518009953 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1338518009954 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1338518009955 substrate binding site [chemical binding]; other site 1338518009956 active site 1338518009957 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1338518009958 hexamer interface [polypeptide binding]; other site 1338518009959 RNA binding site [nucleotide binding]; other site 1338518009960 Histidine-zinc binding site [chemical binding]; other site 1338518009961 urocanate hydratase; Provisional; Region: PRK05414 1338518009962 imidazolonepropionase; Validated; Region: PRK09356 1338518009963 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1338518009964 active site 1338518009965 S-methylmethionine transporter; Provisional; Region: PRK11387 1338518009966 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1338518009967 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1338518009968 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1338518009969 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1338518009970 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1338518009971 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1338518009972 Nucleoside recognition; Region: Gate; pfam07670 1338518009973 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1338518009974 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1338518009975 intersubunit interface [polypeptide binding]; other site 1338518009976 active site 1338518009977 catalytic residue [active] 1338518009978 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1338518009979 MarR family; Region: MarR_2; pfam12802 1338518009980 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1338518009981 sugar phosphate phosphatase; Provisional; Region: PRK10513 1338518009982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518009983 active site 1338518009984 motif I; other site 1338518009985 motif II; other site 1338518009986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1338518009987 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1338518009988 SlyX; Region: SlyX; cl01090 1338518009989 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1338518009990 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1338518009991 putative ligand binding residues [chemical binding]; other site 1338518009992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1338518009993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518009994 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1338518009995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518009996 ATP binding site [chemical binding]; other site 1338518009997 Mg2+ binding site [ion binding]; other site 1338518009998 G-X-G motif; other site 1338518009999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518010000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518010001 active site 1338518010002 phosphorylation site [posttranslational modification] 1338518010003 intermolecular recognition site; other site 1338518010004 dimerization interface [polypeptide binding]; other site 1338518010005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518010006 DNA binding site [nucleotide binding] 1338518010007 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1338518010008 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1338518010009 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1338518010010 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1338518010011 DNA interaction; other site 1338518010012 Metal-binding active site; metal-binding site 1338518010013 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1338518010014 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1338518010015 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1338518010016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518010017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518010018 putative substrate translocation pore; other site 1338518010019 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1338518010020 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1338518010021 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1338518010022 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1338518010023 tetrameric interface [polypeptide binding]; other site 1338518010024 NAD binding site [chemical binding]; other site 1338518010025 catalytic residues [active] 1338518010026 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1338518010027 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1338518010028 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1338518010029 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1338518010030 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1338518010031 active site 1338518010032 catalytic tetrad [active] 1338518010033 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1338518010034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518010035 putative substrate translocation pore; other site 1338518010036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518010037 heat shock protein 90; Provisional; Region: PRK05218 1338518010038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518010039 ATP binding site [chemical binding]; other site 1338518010040 Mg2+ binding site [ion binding]; other site 1338518010041 G-X-G motif; other site 1338518010042 short chain dehydrogenase; Validated; Region: PRK08589 1338518010043 classical (c) SDRs; Region: SDR_c; cd05233 1338518010044 NAD(P) binding site [chemical binding]; other site 1338518010045 active site 1338518010046 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518010047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518010048 active site 1338518010049 phosphorylation site [posttranslational modification] 1338518010050 intermolecular recognition site; other site 1338518010051 dimerization interface [polypeptide binding]; other site 1338518010052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518010053 DNA binding residues [nucleotide binding] 1338518010054 dimerization interface [polypeptide binding]; other site 1338518010055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1338518010056 Histidine kinase; Region: HisKA_3; pfam07730 1338518010057 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1338518010058 ATP binding site [chemical binding]; other site 1338518010059 Mg2+ binding site [ion binding]; other site 1338518010060 G-X-G motif; other site 1338518010061 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1338518010062 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1338518010063 putative di-iron ligands [ion binding]; other site 1338518010064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518010065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518010066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1338518010067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1338518010068 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1338518010069 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1338518010070 NAD(P) binding site [chemical binding]; other site 1338518010071 catalytic residues [active] 1338518010072 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1338518010073 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1338518010074 Trp docking motif [polypeptide binding]; other site 1338518010075 active site 1338518010076 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1338518010077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518010078 putative substrate translocation pore; other site 1338518010079 RDD family; Region: RDD; pfam06271 1338518010080 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518010081 active site 1338518010082 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1338518010083 peroxiredoxin; Region: AhpC; TIGR03137 1338518010084 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1338518010085 dimer interface [polypeptide binding]; other site 1338518010086 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1338518010087 catalytic triad [active] 1338518010088 peroxidatic and resolving cysteines [active] 1338518010089 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1338518010090 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1338518010091 catalytic residue [active] 1338518010092 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1338518010093 catalytic residues [active] 1338518010094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1338518010095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1338518010096 Fic family protein [Function unknown]; Region: COG3177 1338518010097 Fic/DOC family; Region: Fic; pfam02661 1338518010098 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1338518010099 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1338518010100 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1338518010101 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1338518010102 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1338518010103 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1338518010104 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1338518010105 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1338518010106 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1338518010107 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1338518010108 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1338518010109 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1338518010110 MarR family; Region: MarR_2; cl17246 1338518010111 Restriction endonuclease; Region: Mrr_cat; pfam04471 1338518010112 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1338518010113 metal binding triad [ion binding]; metal-binding site 1338518010114 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1338518010115 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1338518010116 Zn2+ binding site [ion binding]; other site 1338518010117 Mg2+ binding site [ion binding]; other site 1338518010118 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1338518010119 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1338518010120 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1338518010121 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1338518010122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1338518010123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1338518010124 active site 1338518010125 catalytic tetrad [active] 1338518010126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1338518010127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518010128 Coenzyme A binding pocket [chemical binding]; other site 1338518010129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518010130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1338518010131 Arginase family; Region: Arginase; cd09989 1338518010132 agmatinase; Region: agmatinase; TIGR01230 1338518010133 active site 1338518010134 Mn binding site [ion binding]; other site 1338518010135 oligomer interface [polypeptide binding]; other site 1338518010136 S-methylmethionine transporter; Provisional; Region: PRK11387 1338518010137 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1338518010138 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1338518010139 inhibitor-cofactor binding pocket; inhibition site 1338518010140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518010141 catalytic residue [active] 1338518010142 PAS domain; Region: PAS_9; pfam13426 1338518010143 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1338518010144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1338518010145 Walker A motif; other site 1338518010146 ATP binding site [chemical binding]; other site 1338518010147 Walker B motif; other site 1338518010148 arginine finger; other site 1338518010149 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1338518010150 Cupin-like domain; Region: Cupin_8; pfam13621 1338518010151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518010152 putative substrate translocation pore; other site 1338518010153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1338518010154 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1338518010155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1338518010156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518010157 dimerization interface [polypeptide binding]; other site 1338518010158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518010159 dimer interface [polypeptide binding]; other site 1338518010160 phosphorylation site [posttranslational modification] 1338518010161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518010162 ATP binding site [chemical binding]; other site 1338518010163 Mg2+ binding site [ion binding]; other site 1338518010164 G-X-G motif; other site 1338518010165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1338518010166 DNA binding site [nucleotide binding] 1338518010167 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1338518010168 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1338518010169 protein binding site [polypeptide binding]; other site 1338518010170 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1338518010171 YycH protein; Region: YycI; cl02015 1338518010172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1338518010173 YycH protein; Region: YycH; pfam07435 1338518010174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1338518010175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1338518010176 dimerization interface [polypeptide binding]; other site 1338518010177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1338518010178 putative active site [active] 1338518010179 heme pocket [chemical binding]; other site 1338518010180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1338518010181 dimer interface [polypeptide binding]; other site 1338518010182 phosphorylation site [posttranslational modification] 1338518010183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1338518010184 ATP binding site [chemical binding]; other site 1338518010185 Mg2+ binding site [ion binding]; other site 1338518010186 G-X-G motif; other site 1338518010187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1338518010188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1338518010189 active site 1338518010190 phosphorylation site [posttranslational modification] 1338518010191 intermolecular recognition site; other site 1338518010192 dimerization interface [polypeptide binding]; other site 1338518010193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1338518010194 DNA binding site [nucleotide binding] 1338518010195 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1338518010196 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1338518010197 GDP-binding site [chemical binding]; other site 1338518010198 ACT binding site; other site 1338518010199 IMP binding site; other site 1338518010200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518010201 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1338518010202 active site 1338518010203 replicative DNA helicase; Provisional; Region: PRK05748 1338518010204 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1338518010205 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1338518010206 Walker A motif; other site 1338518010207 ATP binding site [chemical binding]; other site 1338518010208 Walker B motif; other site 1338518010209 DNA binding loops [nucleotide binding] 1338518010210 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1338518010211 YycC-like protein; Region: YycC; pfam14174 1338518010212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1338518010213 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1338518010214 Phosphotransferase enzyme family; Region: APH; pfam01636 1338518010215 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1338518010216 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1338518010217 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1338518010218 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1338518010219 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1338518010220 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1338518010221 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1338518010222 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1338518010223 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1338518010224 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1338518010225 diguanylate cyclase; Region: GGDEF; smart00267 1338518010226 DHH family; Region: DHH; pfam01368 1338518010227 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1338518010228 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1338518010229 Predicted transcriptional regulators [Transcription]; Region: COG1733 1338518010230 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1338518010231 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1338518010232 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1338518010233 DHHA2 domain; Region: DHHA2; pfam02833 1338518010234 EamA-like transporter family; Region: EamA; pfam00892 1338518010235 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1338518010236 EamA-like transporter family; Region: EamA; pfam00892 1338518010237 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1338518010238 active site 1338518010239 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1338518010240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518010241 DNA-binding site [nucleotide binding]; DNA binding site 1338518010242 FCD domain; Region: FCD; pfam07729 1338518010243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1338518010244 DinB superfamily; Region: DinB_2; pfam12867 1338518010245 H+ Antiporter protein; Region: 2A0121; TIGR00900 1338518010246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518010247 putative substrate translocation pore; other site 1338518010248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1338518010249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1338518010250 DNA binding residues [nucleotide binding] 1338518010251 dimerization interface [polypeptide binding]; other site 1338518010252 anthranilate synthase; Provisional; Region: PRK13566 1338518010253 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1338518010254 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1338518010255 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1338518010256 glutamine binding [chemical binding]; other site 1338518010257 catalytic triad [active] 1338518010258 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1338518010259 EamA-like transporter family; Region: EamA; pfam00892 1338518010260 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 1338518010261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518010262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518010263 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1338518010264 dimerization interface [polypeptide binding]; other site 1338518010265 LysE type translocator; Region: LysE; cl00565 1338518010266 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1338518010267 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1338518010268 dimer interface [polypeptide binding]; other site 1338518010269 FMN binding site [chemical binding]; other site 1338518010270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518010271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1338518010272 putative DNA binding site [nucleotide binding]; other site 1338518010273 putative Zn2+ binding site [ion binding]; other site 1338518010274 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518010275 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1338518010276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1338518010277 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1338518010278 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1338518010279 MarR family; Region: MarR; pfam01047 1338518010280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518010281 Coenzyme A binding pocket [chemical binding]; other site 1338518010282 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1338518010283 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1338518010284 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1338518010285 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1338518010286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1338518010287 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1338518010288 putative dimerization interface [polypeptide binding]; other site 1338518010289 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1338518010290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1338518010291 DNA-binding site [nucleotide binding]; DNA binding site 1338518010292 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1338518010293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1338518010294 homodimer interface [polypeptide binding]; other site 1338518010295 catalytic residue [active] 1338518010296 EamA-like transporter family; Region: EamA; pfam00892 1338518010297 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1338518010298 EamA-like transporter family; Region: EamA; pfam00892 1338518010299 CAAX protease self-immunity; Region: Abi; pfam02517 1338518010300 benzoate transport; Region: 2A0115; TIGR00895 1338518010301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518010302 putative substrate translocation pore; other site 1338518010303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1338518010304 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1338518010305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1338518010306 putative metal binding site [ion binding]; other site 1338518010307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1338518010308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1338518010309 DNA binding site [nucleotide binding] 1338518010310 domain linker motif; other site 1338518010311 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1338518010312 putative dimerization interface [polypeptide binding]; other site 1338518010313 putative ligand binding site [chemical binding]; other site 1338518010314 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1338518010315 active site 1338518010316 putative catalytic site [active] 1338518010317 DNA binding site [nucleotide binding] 1338518010318 putative phosphate binding site [ion binding]; other site 1338518010319 metal binding site A [ion binding]; metal-binding site 1338518010320 AP binding site [nucleotide binding]; other site 1338518010321 metal binding site B [ion binding]; metal-binding site 1338518010322 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1338518010323 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1338518010324 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1338518010325 DNA binding site [nucleotide binding] 1338518010326 active site 1338518010327 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1338518010328 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1338518010329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518010330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1338518010331 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1338518010332 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1338518010333 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1338518010334 dimer interface [polypeptide binding]; other site 1338518010335 ssDNA binding site [nucleotide binding]; other site 1338518010336 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1338518010337 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1338518010338 GTP-binding protein YchF; Reviewed; Region: PRK09601 1338518010339 YchF GTPase; Region: YchF; cd01900 1338518010340 G1 box; other site 1338518010341 GTP/Mg2+ binding site [chemical binding]; other site 1338518010342 Switch I region; other site 1338518010343 G2 box; other site 1338518010344 Switch II region; other site 1338518010345 G3 box; other site 1338518010346 G4 box; other site 1338518010347 G5 box; other site 1338518010348 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1338518010349 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1338518010350 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1338518010351 putative [4Fe-4S] binding site [ion binding]; other site 1338518010352 putative molybdopterin cofactor binding site [chemical binding]; other site 1338518010353 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1338518010354 molybdopterin cofactor binding site; other site 1338518010355 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1338518010356 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1338518010357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1338518010358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1338518010359 Coenzyme A binding pocket [chemical binding]; other site 1338518010360 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1338518010361 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1338518010362 ParB-like nuclease domain; Region: ParB; smart00470 1338518010363 KorB domain; Region: KorB; pfam08535 1338518010364 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1338518010365 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1338518010366 P-loop; other site 1338518010367 Magnesium ion binding site [ion binding]; other site 1338518010368 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1338518010369 Magnesium ion binding site [ion binding]; other site 1338518010370 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1338518010371 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1338518010372 ParB-like nuclease domain; Region: ParB; smart00470 1338518010373 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1338518010374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1338518010375 S-adenosylmethionine binding site [chemical binding]; other site 1338518010376 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1338518010377 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1338518010378 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1338518010379 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1338518010380 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1338518010381 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1338518010382 G1 box; other site 1338518010383 GTP/Mg2+ binding site [chemical binding]; other site 1338518010384 Switch I region; other site 1338518010385 G2 box; other site 1338518010386 Switch II region; other site 1338518010387 G3 box; other site 1338518010388 G4 box; other site 1338518010389 G5 box; other site 1338518010390 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1338518010391 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1338518010392 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1338518010393 G-X-X-G motif; other site 1338518010394 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1338518010395 RxxxH motif; other site 1338518010396 OxaA-like protein precursor; Validated; Region: PRK02944 1338518010397 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1338518010398 ribonuclease P; Reviewed; Region: rnpA; PRK00499