-- dump date 20140618_211515 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1150475000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1150475000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1150475000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475000004 Walker A motif; other site 1150475000005 ATP binding site [chemical binding]; other site 1150475000006 Walker B motif; other site 1150475000007 arginine finger; other site 1150475000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1150475000009 DnaA box-binding interface [nucleotide binding]; other site 1150475000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1150475000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1150475000012 putative DNA binding surface [nucleotide binding]; other site 1150475000013 dimer interface [polypeptide binding]; other site 1150475000014 beta-clamp/clamp loader binding surface; other site 1150475000015 beta-clamp/translesion DNA polymerase binding surface; other site 1150475000016 S4 domain; Region: S4_2; pfam13275 1150475000017 recombination protein F; Reviewed; Region: recF; PRK00064 1150475000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1150475000019 Walker A/P-loop; other site 1150475000020 ATP binding site [chemical binding]; other site 1150475000021 Q-loop/lid; other site 1150475000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475000023 ABC transporter signature motif; other site 1150475000024 Walker B; other site 1150475000025 D-loop; other site 1150475000026 H-loop/switch region; other site 1150475000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1150475000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475000029 ATP binding site [chemical binding]; other site 1150475000030 Mg2+ binding site [ion binding]; other site 1150475000031 G-X-G motif; other site 1150475000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1150475000033 anchoring element; other site 1150475000034 dimer interface [polypeptide binding]; other site 1150475000035 ATP binding site [chemical binding]; other site 1150475000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1150475000037 active site 1150475000038 putative metal-binding site [ion binding]; other site 1150475000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1150475000040 DNA gyrase subunit A; Validated; Region: PRK05560 1150475000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1150475000042 CAP-like domain; other site 1150475000043 active site 1150475000044 primary dimer interface [polypeptide binding]; other site 1150475000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475000051 YaaC-like Protein; Region: YaaC; pfam14175 1150475000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1150475000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1150475000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1150475000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1150475000056 active site 1150475000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1150475000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1150475000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1150475000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1150475000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1150475000062 active site 1150475000063 multimer interface [polypeptide binding]; other site 1150475000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1150475000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1150475000066 predicted active site [active] 1150475000067 catalytic triad [active] 1150475000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 1150475000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1150475000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1150475000071 dimer interface [polypeptide binding]; other site 1150475000072 active site 1150475000073 motif 1; other site 1150475000074 motif 2; other site 1150475000075 motif 3; other site 1150475000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1150475000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1150475000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1150475000079 Substrate-binding site [chemical binding]; other site 1150475000080 Substrate specificity [chemical binding]; other site 1150475000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1150475000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1150475000083 Substrate-binding site [chemical binding]; other site 1150475000084 Substrate specificity [chemical binding]; other site 1150475000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1150475000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1150475000089 active site 1150475000090 Isochorismatase family; Region: Isochorismatase; pfam00857 1150475000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1150475000092 catalytic triad [active] 1150475000093 conserved cis-peptide bond; other site 1150475000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1150475000095 nucleoside/Zn binding site; other site 1150475000096 dimer interface [polypeptide binding]; other site 1150475000097 catalytic motif [active] 1150475000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1150475000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475000100 Walker A motif; other site 1150475000101 ATP binding site [chemical binding]; other site 1150475000102 Walker B motif; other site 1150475000103 arginine finger; other site 1150475000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1150475000105 hypothetical protein; Validated; Region: PRK00153 1150475000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 1150475000107 RecR protein; Region: RecR; pfam02132 1150475000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1150475000109 putative active site [active] 1150475000110 putative metal-binding site [ion binding]; other site 1150475000111 tetramer interface [polypeptide binding]; other site 1150475000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1150475000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 1150475000114 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1150475000115 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1150475000116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1150475000117 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1150475000118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1150475000119 homodimer interface [polypeptide binding]; other site 1150475000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475000121 catalytic residue [active] 1150475000122 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1150475000123 thymidylate kinase; Validated; Region: tmk; PRK00698 1150475000124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1150475000125 TMP-binding site; other site 1150475000126 ATP-binding site [chemical binding]; other site 1150475000127 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1150475000128 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1150475000129 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1150475000130 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1150475000131 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1150475000132 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1150475000133 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1150475000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475000135 S-adenosylmethionine binding site [chemical binding]; other site 1150475000136 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1150475000137 GIY-YIG motif/motif A; other site 1150475000138 putative active site [active] 1150475000139 putative metal binding site [ion binding]; other site 1150475000140 Predicted methyltransferases [General function prediction only]; Region: COG0313 1150475000141 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1150475000142 putative SAM binding site [chemical binding]; other site 1150475000143 putative homodimer interface [polypeptide binding]; other site 1150475000144 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1150475000145 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1150475000146 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1150475000147 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1150475000148 active site 1150475000149 HIGH motif; other site 1150475000150 KMSKS motif; other site 1150475000151 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1150475000152 tRNA binding surface [nucleotide binding]; other site 1150475000153 anticodon binding site; other site 1150475000154 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1150475000155 dimer interface [polypeptide binding]; other site 1150475000156 putative tRNA-binding site [nucleotide binding]; other site 1150475000157 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1150475000158 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1150475000159 active site 1150475000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1150475000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1150475000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1150475000163 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1150475000164 G5 domain; Region: G5; pfam07501 1150475000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1150475000166 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1150475000167 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1150475000168 putative active site [active] 1150475000169 putative metal binding site [ion binding]; other site 1150475000170 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1150475000171 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1150475000172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475000173 S-adenosylmethionine binding site [chemical binding]; other site 1150475000174 YabG peptidase U57; Region: Peptidase_U57; pfam05582 1150475000175 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1150475000176 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1150475000177 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1150475000178 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1150475000179 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1150475000180 pur operon repressor; Provisional; Region: PRK09213 1150475000181 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1150475000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475000183 active site 1150475000184 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1150475000185 homotrimer interaction site [polypeptide binding]; other site 1150475000186 putative active site [active] 1150475000187 regulatory protein SpoVG; Reviewed; Region: PRK13259 1150475000188 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1150475000189 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1150475000190 Substrate binding site; other site 1150475000191 Mg++ binding site; other site 1150475000192 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1150475000193 active site 1150475000194 substrate binding site [chemical binding]; other site 1150475000195 CoA binding site [chemical binding]; other site 1150475000196 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1150475000197 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1150475000198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475000199 active site 1150475000200 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1150475000201 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1150475000202 5S rRNA interface [nucleotide binding]; other site 1150475000203 CTC domain interface [polypeptide binding]; other site 1150475000204 L16 interface [polypeptide binding]; other site 1150475000205 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1150475000206 putative active site [active] 1150475000207 catalytic residue [active] 1150475000208 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1150475000209 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1150475000210 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1150475000211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475000212 ATP binding site [chemical binding]; other site 1150475000213 putative Mg++ binding site [ion binding]; other site 1150475000214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475000215 nucleotide binding region [chemical binding]; other site 1150475000216 ATP-binding site [chemical binding]; other site 1150475000217 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1150475000218 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1150475000219 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1150475000220 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1150475000221 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1150475000222 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1150475000223 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1150475000224 putative SAM binding site [chemical binding]; other site 1150475000225 putative homodimer interface [polypeptide binding]; other site 1150475000226 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1150475000227 homodimer interface [polypeptide binding]; other site 1150475000228 metal binding site [ion binding]; metal-binding site 1150475000229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1150475000230 homodimer interface [polypeptide binding]; other site 1150475000231 active site 1150475000232 putative chemical substrate binding site [chemical binding]; other site 1150475000233 metal binding site [ion binding]; metal-binding site 1150475000234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1150475000235 RNA binding surface [nucleotide binding]; other site 1150475000236 sporulation protein YabP; Region: spore_yabP; TIGR02892 1150475000237 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1150475000238 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1150475000239 Septum formation initiator; Region: DivIC; pfam04977 1150475000240 hypothetical protein; Provisional; Region: PRK08582 1150475000241 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1150475000242 RNA binding site [nucleotide binding]; other site 1150475000243 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1150475000244 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1150475000245 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1150475000246 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1150475000247 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1150475000248 metal ion-dependent adhesion site (MIDAS); other site 1150475000249 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1150475000250 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1150475000251 active site 1150475000252 ATP binding site [chemical binding]; other site 1150475000253 substrate binding site [chemical binding]; other site 1150475000254 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1150475000255 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1150475000256 Ligand Binding Site [chemical binding]; other site 1150475000257 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1150475000258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475000259 active site 1150475000260 FtsH Extracellular; Region: FtsH_ext; pfam06480 1150475000261 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1150475000262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475000263 Walker A motif; other site 1150475000264 ATP binding site [chemical binding]; other site 1150475000265 Walker B motif; other site 1150475000266 arginine finger; other site 1150475000267 Peptidase family M41; Region: Peptidase_M41; pfam01434 1150475000268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1150475000269 nucleotide binding site [chemical binding]; other site 1150475000270 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1150475000271 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1150475000272 dimerization interface [polypeptide binding]; other site 1150475000273 domain crossover interface; other site 1150475000274 redox-dependent activation switch; other site 1150475000275 SurA N-terminal domain; Region: SurA_N_3; cl07813 1150475000276 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1150475000277 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1150475000278 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1150475000279 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1150475000280 dimer interface [polypeptide binding]; other site 1150475000281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475000282 catalytic residue [active] 1150475000283 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1150475000284 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1150475000285 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1150475000286 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1150475000287 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1150475000288 glutamine binding [chemical binding]; other site 1150475000289 catalytic triad [active] 1150475000290 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1150475000291 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1150475000292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475000293 catalytic residue [active] 1150475000294 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1150475000295 dihydropteroate synthase; Region: DHPS; TIGR01496 1150475000296 substrate binding pocket [chemical binding]; other site 1150475000297 dimer interface [polypeptide binding]; other site 1150475000298 inhibitor binding site; inhibition site 1150475000299 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1150475000300 homooctamer interface [polypeptide binding]; other site 1150475000301 active site 1150475000302 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1150475000303 catalytic center binding site [active] 1150475000304 ATP binding site [chemical binding]; other site 1150475000305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1150475000306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475000307 non-specific DNA binding site [nucleotide binding]; other site 1150475000308 salt bridge; other site 1150475000309 sequence-specific DNA binding site [nucleotide binding]; other site 1150475000310 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1150475000311 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1150475000312 FMN binding site [chemical binding]; other site 1150475000313 active site 1150475000314 catalytic residues [active] 1150475000315 substrate binding site [chemical binding]; other site 1150475000316 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1150475000317 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1150475000318 dimer interface [polypeptide binding]; other site 1150475000319 putative anticodon binding site; other site 1150475000320 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1150475000321 motif 1; other site 1150475000322 active site 1150475000323 motif 2; other site 1150475000324 motif 3; other site 1150475000325 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1150475000326 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1150475000327 UvrB/uvrC motif; Region: UVR; pfam02151 1150475000328 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1150475000329 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1150475000330 ADP binding site [chemical binding]; other site 1150475000331 phosphagen binding site; other site 1150475000332 substrate specificity loop; other site 1150475000333 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1150475000334 Clp amino terminal domain; Region: Clp_N; pfam02861 1150475000335 Clp amino terminal domain; Region: Clp_N; pfam02861 1150475000336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475000337 Walker A motif; other site 1150475000338 ATP binding site [chemical binding]; other site 1150475000339 Walker B motif; other site 1150475000340 arginine finger; other site 1150475000341 UvrB/uvrC motif; Region: UVR; pfam02151 1150475000342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475000343 Walker A motif; other site 1150475000344 ATP binding site [chemical binding]; other site 1150475000345 Walker B motif; other site 1150475000346 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1150475000347 DNA repair protein RadA; Provisional; Region: PRK11823 1150475000348 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1150475000349 Walker A motif/ATP binding site; other site 1150475000350 ATP binding site [chemical binding]; other site 1150475000351 Walker B motif; other site 1150475000352 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1150475000353 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1150475000354 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1150475000355 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1150475000356 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1150475000357 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1150475000358 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1150475000359 putative active site [active] 1150475000360 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1150475000361 substrate binding site; other site 1150475000362 dimer interface; other site 1150475000363 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1150475000364 homotrimer interaction site [polypeptide binding]; other site 1150475000365 zinc binding site [ion binding]; other site 1150475000366 CDP-binding sites; other site 1150475000367 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1150475000368 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1150475000369 HIGH motif; other site 1150475000370 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1150475000371 active site 1150475000372 KMSKS motif; other site 1150475000373 serine O-acetyltransferase; Region: cysE; TIGR01172 1150475000374 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1150475000375 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1150475000376 trimer interface [polypeptide binding]; other site 1150475000377 active site 1150475000378 substrate binding site [chemical binding]; other site 1150475000379 CoA binding site [chemical binding]; other site 1150475000380 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1150475000381 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1150475000382 active site 1150475000383 HIGH motif; other site 1150475000384 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1150475000385 KMSKS motif; other site 1150475000386 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1150475000387 tRNA binding surface [nucleotide binding]; other site 1150475000388 anticodon binding site; other site 1150475000389 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1150475000390 active site 1150475000391 metal binding site [ion binding]; metal-binding site 1150475000392 dimerization interface [polypeptide binding]; other site 1150475000393 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1150475000394 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1150475000395 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1150475000396 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1150475000397 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1150475000398 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475000399 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1150475000400 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1150475000401 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1150475000402 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1150475000403 putative homodimer interface [polypeptide binding]; other site 1150475000404 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1150475000405 heterodimer interface [polypeptide binding]; other site 1150475000406 homodimer interface [polypeptide binding]; other site 1150475000407 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1150475000408 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1150475000409 23S rRNA interface [nucleotide binding]; other site 1150475000410 L7/L12 interface [polypeptide binding]; other site 1150475000411 putative thiostrepton binding site; other site 1150475000412 L25 interface [polypeptide binding]; other site 1150475000413 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1150475000414 mRNA/rRNA interface [nucleotide binding]; other site 1150475000415 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1150475000416 23S rRNA interface [nucleotide binding]; other site 1150475000417 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1150475000418 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1150475000419 core dimer interface [polypeptide binding]; other site 1150475000420 peripheral dimer interface [polypeptide binding]; other site 1150475000421 L10 interface [polypeptide binding]; other site 1150475000422 L11 interface [polypeptide binding]; other site 1150475000423 putative EF-Tu interaction site [polypeptide binding]; other site 1150475000424 putative EF-G interaction site [polypeptide binding]; other site 1150475000425 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1150475000426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475000427 S-adenosylmethionine binding site [chemical binding]; other site 1150475000428 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1150475000429 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1150475000430 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1150475000431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1150475000432 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1150475000433 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1150475000434 RPB1 interaction site [polypeptide binding]; other site 1150475000435 RPB10 interaction site [polypeptide binding]; other site 1150475000436 RPB11 interaction site [polypeptide binding]; other site 1150475000437 RPB3 interaction site [polypeptide binding]; other site 1150475000438 RPB12 interaction site [polypeptide binding]; other site 1150475000439 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1150475000440 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1150475000441 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1150475000442 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1150475000443 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1150475000444 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1150475000445 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1150475000446 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1150475000447 G-loop; other site 1150475000448 DNA binding site [nucleotide binding] 1150475000449 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1150475000450 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1150475000451 S17 interaction site [polypeptide binding]; other site 1150475000452 S8 interaction site; other site 1150475000453 16S rRNA interaction site [nucleotide binding]; other site 1150475000454 streptomycin interaction site [chemical binding]; other site 1150475000455 23S rRNA interaction site [nucleotide binding]; other site 1150475000456 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1150475000457 30S ribosomal protein S7; Validated; Region: PRK05302 1150475000458 elongation factor G; Reviewed; Region: PRK00007 1150475000459 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1150475000460 G1 box; other site 1150475000461 putative GEF interaction site [polypeptide binding]; other site 1150475000462 GTP/Mg2+ binding site [chemical binding]; other site 1150475000463 Switch I region; other site 1150475000464 G2 box; other site 1150475000465 G3 box; other site 1150475000466 Switch II region; other site 1150475000467 G4 box; other site 1150475000468 G5 box; other site 1150475000469 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1150475000470 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1150475000471 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1150475000472 elongation factor Tu; Reviewed; Region: PRK00049 1150475000473 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1150475000474 G1 box; other site 1150475000475 GEF interaction site [polypeptide binding]; other site 1150475000476 GTP/Mg2+ binding site [chemical binding]; other site 1150475000477 Switch I region; other site 1150475000478 G2 box; other site 1150475000479 G3 box; other site 1150475000480 Switch II region; other site 1150475000481 G4 box; other site 1150475000482 G5 box; other site 1150475000483 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1150475000484 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1150475000485 Antibiotic Binding Site [chemical binding]; other site 1150475000486 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1150475000487 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1150475000488 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1150475000489 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1150475000490 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1150475000491 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1150475000492 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1150475000493 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1150475000494 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1150475000495 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1150475000496 putative translocon binding site; other site 1150475000497 protein-rRNA interface [nucleotide binding]; other site 1150475000498 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1150475000499 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1150475000500 G-X-X-G motif; other site 1150475000501 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1150475000502 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1150475000503 23S rRNA interface [nucleotide binding]; other site 1150475000504 5S rRNA interface [nucleotide binding]; other site 1150475000505 putative antibiotic binding site [chemical binding]; other site 1150475000506 L25 interface [polypeptide binding]; other site 1150475000507 L27 interface [polypeptide binding]; other site 1150475000508 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1150475000509 23S rRNA interface [nucleotide binding]; other site 1150475000510 putative translocon interaction site; other site 1150475000511 signal recognition particle (SRP54) interaction site; other site 1150475000512 L23 interface [polypeptide binding]; other site 1150475000513 trigger factor interaction site; other site 1150475000514 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1150475000515 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1150475000516 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1150475000517 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1150475000518 RNA binding site [nucleotide binding]; other site 1150475000519 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1150475000520 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1150475000521 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1150475000522 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1150475000523 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1150475000524 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1150475000525 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1150475000526 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1150475000527 5S rRNA interface [nucleotide binding]; other site 1150475000528 L27 interface [polypeptide binding]; other site 1150475000529 23S rRNA interface [nucleotide binding]; other site 1150475000530 L5 interface [polypeptide binding]; other site 1150475000531 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1150475000532 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1150475000533 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1150475000534 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1150475000535 23S rRNA binding site [nucleotide binding]; other site 1150475000536 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1150475000537 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1150475000538 SecY translocase; Region: SecY; pfam00344 1150475000539 adenylate kinase; Reviewed; Region: adk; PRK00279 1150475000540 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1150475000541 AMP-binding site [chemical binding]; other site 1150475000542 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1150475000543 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1150475000544 active site 1150475000545 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1150475000546 rRNA binding site [nucleotide binding]; other site 1150475000547 predicted 30S ribosome binding site; other site 1150475000548 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1150475000549 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1150475000550 30S ribosomal protein S11; Validated; Region: PRK05309 1150475000551 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1150475000552 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1150475000553 alphaNTD homodimer interface [polypeptide binding]; other site 1150475000554 alphaNTD - beta interaction site [polypeptide binding]; other site 1150475000555 alphaNTD - beta' interaction site [polypeptide binding]; other site 1150475000556 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1150475000557 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1150475000558 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1150475000559 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1150475000560 Walker A/P-loop; other site 1150475000561 ATP binding site [chemical binding]; other site 1150475000562 Q-loop/lid; other site 1150475000563 ABC transporter signature motif; other site 1150475000564 Walker B; other site 1150475000565 D-loop; other site 1150475000566 H-loop/switch region; other site 1150475000567 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1150475000568 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1150475000569 Walker A/P-loop; other site 1150475000570 ATP binding site [chemical binding]; other site 1150475000571 Q-loop/lid; other site 1150475000572 ABC transporter signature motif; other site 1150475000573 Walker B; other site 1150475000574 D-loop; other site 1150475000575 H-loop/switch region; other site 1150475000576 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1150475000577 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1150475000578 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1150475000579 dimerization interface 3.5A [polypeptide binding]; other site 1150475000580 active site 1150475000581 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1150475000582 23S rRNA interface [nucleotide binding]; other site 1150475000583 L3 interface [polypeptide binding]; other site 1150475000584 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1150475000585 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1150475000586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475000587 S-adenosylmethionine binding site [chemical binding]; other site 1150475000588 DinB family; Region: DinB; cl17821 1150475000589 DinB superfamily; Region: DinB_2; pfam12867 1150475000590 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1150475000591 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1150475000592 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1150475000593 active site 1150475000594 metal binding site [ion binding]; metal-binding site 1150475000595 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1150475000596 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1150475000597 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1150475000598 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1150475000599 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1150475000600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000601 putative substrate translocation pore; other site 1150475000602 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1150475000603 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475000604 inhibitor-cofactor binding pocket; inhibition site 1150475000605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475000606 catalytic residue [active] 1150475000607 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1150475000608 active site 1150475000609 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1150475000610 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1150475000611 NAD(P) binding site [chemical binding]; other site 1150475000612 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1150475000613 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1150475000614 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1150475000615 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1150475000616 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1150475000617 Sodium Bile acid symporter family; Region: SBF; cl17470 1150475000618 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1150475000619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475000620 ABC-ATPase subunit interface; other site 1150475000621 dimer interface [polypeptide binding]; other site 1150475000622 putative PBP binding regions; other site 1150475000623 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1150475000624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475000625 ABC-ATPase subunit interface; other site 1150475000626 dimer interface [polypeptide binding]; other site 1150475000627 putative PBP binding regions; other site 1150475000628 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1150475000629 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1150475000630 intersubunit interface [polypeptide binding]; other site 1150475000631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1150475000632 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1150475000633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1150475000634 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1150475000635 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1150475000636 intersubunit interface [polypeptide binding]; other site 1150475000637 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1150475000638 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1150475000639 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1150475000640 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1150475000641 putative periplasmic esterase; Provisional; Region: PRK03642 1150475000642 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1150475000643 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1150475000644 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1150475000645 active site turn [active] 1150475000646 phosphorylation site [posttranslational modification] 1150475000647 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1150475000648 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1150475000649 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1150475000650 putative active site [active] 1150475000651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1150475000652 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1150475000653 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1150475000654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475000655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475000656 DNA binding residues [nucleotide binding] 1150475000657 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1150475000658 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1150475000659 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1150475000660 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1150475000661 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1150475000662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1150475000663 YbbR-like protein; Region: YbbR; pfam07949 1150475000664 YbbR-like protein; Region: YbbR; pfam07949 1150475000665 YbbR-like protein; Region: YbbR; pfam07949 1150475000666 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1150475000667 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1150475000668 active site 1150475000669 substrate binding site [chemical binding]; other site 1150475000670 metal binding site [ion binding]; metal-binding site 1150475000671 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1150475000672 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1150475000673 glutaminase active site [active] 1150475000674 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1150475000675 dimer interface [polypeptide binding]; other site 1150475000676 active site 1150475000677 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1150475000678 dimer interface [polypeptide binding]; other site 1150475000679 active site 1150475000680 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 1150475000681 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1150475000682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1150475000683 Walker A/P-loop; other site 1150475000684 ATP binding site [chemical binding]; other site 1150475000685 Q-loop/lid; other site 1150475000686 ABC transporter signature motif; other site 1150475000687 Walker B; other site 1150475000688 D-loop; other site 1150475000689 H-loop/switch region; other site 1150475000690 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1150475000691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475000692 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475000693 active site 1150475000694 catalytic tetrad [active] 1150475000695 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1150475000696 holin-like protein; Validated; Region: PRK01658 1150475000697 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475000698 MarR family; Region: MarR; pfam01047 1150475000699 putative transport protein YifK; Provisional; Region: PRK10746 1150475000700 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1150475000701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475000702 active site 1150475000703 motif I; other site 1150475000704 motif II; other site 1150475000705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1150475000706 Histidine kinase; Region: HisKA_3; pfam07730 1150475000707 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1150475000708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475000709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475000710 active site 1150475000711 phosphorylation site [posttranslational modification] 1150475000712 intermolecular recognition site; other site 1150475000713 dimerization interface [polypeptide binding]; other site 1150475000714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475000715 DNA binding residues [nucleotide binding] 1150475000716 dimerization interface [polypeptide binding]; other site 1150475000717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475000718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475000719 Walker A/P-loop; other site 1150475000720 ATP binding site [chemical binding]; other site 1150475000721 Q-loop/lid; other site 1150475000722 ABC transporter signature motif; other site 1150475000723 Walker B; other site 1150475000724 D-loop; other site 1150475000725 H-loop/switch region; other site 1150475000726 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1150475000727 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1150475000728 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1150475000729 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1150475000730 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1150475000731 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1150475000732 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1150475000733 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1150475000734 active site 1150475000735 catalytic site [active] 1150475000736 metal binding site [ion binding]; metal-binding site 1150475000737 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1150475000738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000739 putative substrate translocation pore; other site 1150475000740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000741 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1150475000742 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1150475000743 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1150475000744 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1150475000745 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1150475000746 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1150475000747 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1150475000748 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1150475000749 active site 1150475000750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475000751 non-specific DNA binding site [nucleotide binding]; other site 1150475000752 salt bridge; other site 1150475000753 sequence-specific DNA binding site [nucleotide binding]; other site 1150475000754 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1150475000755 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1150475000756 active site 1150475000757 NAD binding site [chemical binding]; other site 1150475000758 metal binding site [ion binding]; metal-binding site 1150475000759 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1150475000760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1150475000761 ATP-grasp domain; Region: ATP-grasp; pfam02222 1150475000762 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1150475000763 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1150475000764 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1150475000765 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1150475000766 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1150475000767 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1150475000768 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1150475000769 active site residue [active] 1150475000770 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1150475000771 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1150475000772 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1150475000773 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1150475000774 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1150475000775 homodimer interface [polypeptide binding]; other site 1150475000776 substrate-cofactor binding pocket; other site 1150475000777 catalytic residue [active] 1150475000778 S-methylmethionine transporter; Provisional; Region: PRK11387 1150475000779 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1150475000780 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1150475000781 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1150475000782 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1150475000783 glutaminase; Reviewed; Region: PRK12357 1150475000784 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1150475000785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475000786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475000787 ATP binding site [chemical binding]; other site 1150475000788 Mg2+ binding site [ion binding]; other site 1150475000789 G-X-G motif; other site 1150475000790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475000791 Response regulator receiver domain; Region: Response_reg; pfam00072 1150475000792 active site 1150475000793 phosphorylation site [posttranslational modification] 1150475000794 intermolecular recognition site; other site 1150475000795 dimerization interface [polypeptide binding]; other site 1150475000796 YcbB domain; Region: YcbB; pfam08664 1150475000797 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1150475000798 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1150475000799 dodecamer interface 1 [polypeptide binding]; other site 1150475000800 dodecamer interface 2 [polypeptide binding]; other site 1150475000801 trimer interface [polypeptide binding]; other site 1150475000802 TRAP binding interface [polypeptide binding]; other site 1150475000803 Zn binding site [ion binding]; other site 1150475000804 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1150475000805 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1150475000806 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1150475000807 dimer interface [polypeptide binding]; other site 1150475000808 FMN binding site [chemical binding]; other site 1150475000809 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1150475000810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475000811 Zn binding site [ion binding]; other site 1150475000812 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1150475000813 Zn binding site [ion binding]; other site 1150475000814 Predicted membrane protein [Function unknown]; Region: COG2259 1150475000815 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1150475000816 catalytic residues [active] 1150475000817 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1150475000818 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1150475000819 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1150475000820 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1150475000821 putative active site [active] 1150475000822 putative metal binding site [ion binding]; other site 1150475000823 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1150475000824 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1150475000825 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1150475000826 putative substrate binding pocket [chemical binding]; other site 1150475000827 AC domain interface; other site 1150475000828 catalytic triad [active] 1150475000829 AB domain interface; other site 1150475000830 interchain disulfide; other site 1150475000831 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1150475000832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1150475000833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1150475000834 catalytic residue [active] 1150475000835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000836 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1150475000837 putative substrate translocation pore; other site 1150475000838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475000839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475000840 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1150475000841 active site 1150475000842 homotetramer interface [polypeptide binding]; other site 1150475000843 homodimer interface [polypeptide binding]; other site 1150475000844 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1150475000845 Lipase (class 2); Region: Lipase_2; pfam01674 1150475000846 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1150475000847 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1150475000848 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475000849 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475000850 active site 1150475000851 catalytic tetrad [active] 1150475000852 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1150475000853 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1150475000854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475000855 binding surface 1150475000856 TPR motif; other site 1150475000857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1150475000858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475000859 TPR motif; other site 1150475000860 binding surface 1150475000861 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1150475000862 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1150475000863 NAD binding site [chemical binding]; other site 1150475000864 homodimer interface [polypeptide binding]; other site 1150475000865 active site 1150475000866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000867 H+ Antiporter protein; Region: 2A0121; TIGR00900 1150475000868 putative substrate translocation pore; other site 1150475000869 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1150475000870 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1150475000871 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1150475000872 Ca binding site [ion binding]; other site 1150475000873 active site 1150475000874 catalytic site [active] 1150475000875 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1150475000876 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1150475000877 metal binding site [ion binding]; metal-binding site 1150475000878 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1150475000879 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1150475000880 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1150475000881 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475000882 ABC-ATPase subunit interface; other site 1150475000883 dimer interface [polypeptide binding]; other site 1150475000884 putative PBP binding regions; other site 1150475000885 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1150475000886 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1150475000887 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1150475000888 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1150475000889 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1150475000890 putative metal binding site [ion binding]; other site 1150475000891 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1150475000892 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1150475000893 putative metal binding site [ion binding]; other site 1150475000894 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1150475000895 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1150475000896 putative metal binding site [ion binding]; other site 1150475000897 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1150475000898 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1150475000899 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1150475000900 benzoate transport; Region: 2A0115; TIGR00895 1150475000901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000902 putative substrate translocation pore; other site 1150475000903 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1150475000904 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1150475000905 Walker A/P-loop; other site 1150475000906 ATP binding site [chemical binding]; other site 1150475000907 Q-loop/lid; other site 1150475000908 ABC transporter signature motif; other site 1150475000909 Walker B; other site 1150475000910 D-loop; other site 1150475000911 H-loop/switch region; other site 1150475000912 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1150475000913 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1150475000914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475000915 dimer interface [polypeptide binding]; other site 1150475000916 conserved gate region; other site 1150475000917 putative PBP binding loops; other site 1150475000918 ABC-ATPase subunit interface; other site 1150475000919 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1150475000920 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1150475000921 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1150475000922 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1150475000923 amidohydrolase; Region: amidohydrolases; TIGR01891 1150475000924 metal binding site [ion binding]; metal-binding site 1150475000925 putative dimer interface [polypeptide binding]; other site 1150475000926 Predicted membrane protein [Function unknown]; Region: COG1288 1150475000927 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1150475000928 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 1150475000929 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1150475000930 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1150475000931 active site 1150475000932 Ca binding site [ion binding]; other site 1150475000933 catalytic site [active] 1150475000934 Aamy_C domain; Region: Aamy_C; smart00632 1150475000935 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1150475000936 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1150475000937 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1150475000938 NAD binding site [chemical binding]; other site 1150475000939 dimer interface [polypeptide binding]; other site 1150475000940 substrate binding site [chemical binding]; other site 1150475000941 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1150475000942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000943 putative substrate translocation pore; other site 1150475000944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475000946 MarR family; Region: MarR; pfam01047 1150475000947 LysE type translocator; Region: LysE; pfam01810 1150475000948 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1150475000949 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1150475000950 Spore germination protein; Region: Spore_permease; cl17796 1150475000951 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1150475000952 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1150475000953 NAD+ synthetase; Region: nadE; TIGR00552 1150475000954 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1150475000955 homodimer interface [polypeptide binding]; other site 1150475000956 NAD binding pocket [chemical binding]; other site 1150475000957 ATP binding pocket [chemical binding]; other site 1150475000958 Mg binding site [ion binding]; other site 1150475000959 active-site loop [active] 1150475000960 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1150475000961 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1150475000962 AAA domain; Region: AAA_18; pfam13238 1150475000963 active site 1150475000964 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1150475000965 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1150475000966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475000967 D-galactonate transporter; Region: 2A0114; TIGR00893 1150475000968 putative substrate translocation pore; other site 1150475000969 shikimate kinase; Reviewed; Region: aroK; PRK00131 1150475000970 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1150475000971 ADP binding site [chemical binding]; other site 1150475000972 magnesium binding site [ion binding]; other site 1150475000973 putative shikimate binding site; other site 1150475000974 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1150475000975 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1150475000976 Proline dehydrogenase; Region: Pro_dh; pfam01619 1150475000977 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1150475000978 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1150475000979 Glutamate binding site [chemical binding]; other site 1150475000980 homodimer interface [polypeptide binding]; other site 1150475000981 NAD binding site [chemical binding]; other site 1150475000982 catalytic residues [active] 1150475000983 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1150475000984 Na binding site [ion binding]; other site 1150475000985 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1150475000986 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1150475000987 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1150475000988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1150475000989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475000990 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1150475000991 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1150475000992 active site 1150475000993 SAM binding site [chemical binding]; other site 1150475000994 homodimer interface [polypeptide binding]; other site 1150475000995 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1150475000996 [2Fe-2S] cluster binding site [ion binding]; other site 1150475000997 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1150475000998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475000999 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1150475001000 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1150475001001 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1150475001002 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1150475001003 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1150475001004 [4Fe-4S] binding site [ion binding]; other site 1150475001005 molybdopterin cofactor binding site; other site 1150475001006 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1150475001007 molybdopterin cofactor binding site; other site 1150475001008 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1150475001009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1150475001010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475001011 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1150475001012 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1150475001013 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1150475001014 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1150475001015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001016 putative substrate translocation pore; other site 1150475001017 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1150475001018 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1150475001019 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1150475001020 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1150475001021 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1150475001022 NAD binding site [chemical binding]; other site 1150475001023 catalytic Zn binding site [ion binding]; other site 1150475001024 structural Zn binding site [ion binding]; other site 1150475001025 RDD family; Region: RDD; pfam06271 1150475001026 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1150475001027 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1150475001028 beta-galactosidase; Region: BGL; TIGR03356 1150475001029 Competence protein J (ComJ); Region: ComJ; pfam11033 1150475001030 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1150475001031 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1150475001032 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1150475001033 tetramer interface [polypeptide binding]; other site 1150475001034 active site 1150475001035 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1150475001036 active site 1150475001037 dimer interface [polypeptide binding]; other site 1150475001038 magnesium binding site [ion binding]; other site 1150475001039 Predicted transcriptional regulators [Transcription]; Region: COG1733 1150475001040 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1150475001041 Condensation domain; Region: Condensation; pfam00668 1150475001042 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475001043 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475001044 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475001045 acyl-activating enzyme (AAE) consensus motif; other site 1150475001046 AMP binding site [chemical binding]; other site 1150475001047 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475001048 Condensation domain; Region: Condensation; pfam00668 1150475001049 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475001050 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475001051 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1150475001052 acyl-activating enzyme (AAE) consensus motif; other site 1150475001053 AMP binding site [chemical binding]; other site 1150475001054 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475001055 Condensation domain; Region: Condensation; pfam00668 1150475001056 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475001057 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475001058 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475001059 acyl-activating enzyme (AAE) consensus motif; other site 1150475001060 AMP binding site [chemical binding]; other site 1150475001061 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475001062 Condensation domain; Region: Condensation; pfam00668 1150475001063 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475001064 Condensation domain; Region: Condensation; pfam00668 1150475001065 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475001066 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1150475001067 acyl-activating enzyme (AAE) consensus motif; other site 1150475001068 AMP binding site [chemical binding]; other site 1150475001069 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475001070 Condensation domain; Region: Condensation; pfam00668 1150475001071 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475001072 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475001073 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475001074 acyl-activating enzyme (AAE) consensus motif; other site 1150475001075 AMP binding site [chemical binding]; other site 1150475001076 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475001077 Condensation domain; Region: Condensation; pfam00668 1150475001078 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475001079 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475001080 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475001081 acyl-activating enzyme (AAE) consensus motif; other site 1150475001082 AMP binding site [chemical binding]; other site 1150475001083 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475001084 Condensation domain; Region: Condensation; pfam00668 1150475001085 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475001086 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475001087 Condensation domain; Region: Condensation; pfam00668 1150475001088 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475001089 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1150475001090 acyl-activating enzyme (AAE) consensus motif; other site 1150475001091 AMP binding site [chemical binding]; other site 1150475001092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475001093 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1150475001094 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1150475001095 PGAP1-like protein; Region: PGAP1; pfam07819 1150475001096 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1150475001097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475001098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475001099 homodimer interface [polypeptide binding]; other site 1150475001100 catalytic residue [active] 1150475001101 YcxB-like protein; Region: YcxB; pfam14317 1150475001102 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1150475001103 EamA-like transporter family; Region: EamA; pfam00892 1150475001104 EamA-like transporter family; Region: EamA; pfam00892 1150475001105 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1150475001106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475001107 DNA-binding site [nucleotide binding]; DNA binding site 1150475001108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475001109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475001110 homodimer interface [polypeptide binding]; other site 1150475001111 catalytic residue [active] 1150475001112 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1150475001113 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1150475001114 Predicted membrane protein [Function unknown]; Region: COG2364 1150475001115 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475001116 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1150475001117 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1150475001118 Walker A/P-loop; other site 1150475001119 ATP binding site [chemical binding]; other site 1150475001120 Q-loop/lid; other site 1150475001121 ABC transporter signature motif; other site 1150475001122 Walker B; other site 1150475001123 D-loop; other site 1150475001124 H-loop/switch region; other site 1150475001125 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1150475001126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475001127 dimer interface [polypeptide binding]; other site 1150475001128 conserved gate region; other site 1150475001129 putative PBP binding loops; other site 1150475001130 ABC-ATPase subunit interface; other site 1150475001131 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1150475001132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1150475001133 substrate binding pocket [chemical binding]; other site 1150475001134 membrane-bound complex binding site; other site 1150475001135 hinge residues; other site 1150475001136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475001137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475001138 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475001139 dimerization interface [polypeptide binding]; other site 1150475001140 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1150475001141 Flavoprotein; Region: Flavoprotein; pfam02441 1150475001142 UbiD family decarboxylase; Region: TIGR00148 1150475001143 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1150475001144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001145 putative substrate translocation pore; other site 1150475001146 POT family; Region: PTR2; pfam00854 1150475001147 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1150475001148 Right handed beta helix region; Region: Beta_helix; pfam13229 1150475001149 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1150475001150 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1150475001151 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1150475001152 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1150475001153 Spore germination protein; Region: Spore_permease; pfam03845 1150475001154 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1150475001155 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1150475001156 active site 1150475001157 non-prolyl cis peptide bond; other site 1150475001158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475001159 Coenzyme A binding pocket [chemical binding]; other site 1150475001160 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1150475001161 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1150475001162 substrate binding pocket [chemical binding]; other site 1150475001163 membrane-bound complex binding site; other site 1150475001164 hinge residues; other site 1150475001165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475001166 dimer interface [polypeptide binding]; other site 1150475001167 conserved gate region; other site 1150475001168 putative PBP binding loops; other site 1150475001169 ABC-ATPase subunit interface; other site 1150475001170 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1150475001171 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1150475001172 Walker A/P-loop; other site 1150475001173 ATP binding site [chemical binding]; other site 1150475001174 Q-loop/lid; other site 1150475001175 ABC transporter signature motif; other site 1150475001176 Walker B; other site 1150475001177 D-loop; other site 1150475001178 H-loop/switch region; other site 1150475001179 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1150475001180 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1150475001181 metal binding site [ion binding]; metal-binding site 1150475001182 dimer interface [polypeptide binding]; other site 1150475001183 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1150475001184 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1150475001185 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1150475001186 Walker A/P-loop; other site 1150475001187 ATP binding site [chemical binding]; other site 1150475001188 Q-loop/lid; other site 1150475001189 ABC transporter signature motif; other site 1150475001190 Walker B; other site 1150475001191 D-loop; other site 1150475001192 H-loop/switch region; other site 1150475001193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1150475001194 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1150475001195 FtsX-like permease family; Region: FtsX; pfam02687 1150475001196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475001197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475001198 active site 1150475001199 phosphorylation site [posttranslational modification] 1150475001200 intermolecular recognition site; other site 1150475001201 dimerization interface [polypeptide binding]; other site 1150475001202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475001203 DNA binding site [nucleotide binding] 1150475001204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475001205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475001206 dimerization interface [polypeptide binding]; other site 1150475001207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475001208 dimer interface [polypeptide binding]; other site 1150475001209 phosphorylation site [posttranslational modification] 1150475001210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475001211 ATP binding site [chemical binding]; other site 1150475001212 Mg2+ binding site [ion binding]; other site 1150475001213 G-X-G motif; other site 1150475001214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1150475001215 binding surface 1150475001216 TPR motif; other site 1150475001217 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475001218 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475001219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475001220 TPR motif; other site 1150475001221 binding surface 1150475001222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475001223 aspartate kinase; Reviewed; Region: PRK09034 1150475001224 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1150475001225 putative catalytic residues [active] 1150475001226 putative nucleotide binding site [chemical binding]; other site 1150475001227 putative aspartate binding site [chemical binding]; other site 1150475001228 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1150475001229 allosteric regulatory residue; other site 1150475001230 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1150475001231 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1150475001232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475001233 ABC-ATPase subunit interface; other site 1150475001234 dimer interface [polypeptide binding]; other site 1150475001235 putative PBP binding regions; other site 1150475001236 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475001237 ABC-ATPase subunit interface; other site 1150475001238 dimer interface [polypeptide binding]; other site 1150475001239 putative PBP binding regions; other site 1150475001240 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1150475001241 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1150475001242 Walker A/P-loop; other site 1150475001243 ATP binding site [chemical binding]; other site 1150475001244 Q-loop/lid; other site 1150475001245 ABC transporter signature motif; other site 1150475001246 Walker B; other site 1150475001247 D-loop; other site 1150475001248 H-loop/switch region; other site 1150475001249 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1150475001250 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1150475001251 putative ligand binding residues [chemical binding]; other site 1150475001252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475001254 putative substrate translocation pore; other site 1150475001255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475001257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475001258 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1150475001259 dimer interface [polypeptide binding]; other site 1150475001260 FMN binding site [chemical binding]; other site 1150475001261 NADPH bind site [chemical binding]; other site 1150475001262 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1150475001263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475001264 dimerization interface [polypeptide binding]; other site 1150475001265 putative DNA binding site [nucleotide binding]; other site 1150475001266 putative Zn2+ binding site [ion binding]; other site 1150475001267 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1150475001268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475001269 DNA-binding site [nucleotide binding]; DNA binding site 1150475001270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475001271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475001272 homodimer interface [polypeptide binding]; other site 1150475001273 catalytic residue [active] 1150475001274 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1150475001275 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475001276 inhibitor-cofactor binding pocket; inhibition site 1150475001277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475001278 catalytic residue [active] 1150475001279 succinic semialdehyde dehydrogenase; Region: PLN02278 1150475001280 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1150475001281 tetramerization interface [polypeptide binding]; other site 1150475001282 NAD(P) binding site [chemical binding]; other site 1150475001283 catalytic residues [active] 1150475001284 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1150475001285 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1150475001286 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1150475001287 NAD binding site [chemical binding]; other site 1150475001288 homodimer interface [polypeptide binding]; other site 1150475001289 active site 1150475001290 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1150475001291 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1150475001292 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1150475001293 YtkA-like; Region: YtkA; pfam13115 1150475001294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1150475001295 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1150475001296 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1150475001297 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1150475001298 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1150475001299 active site 1150475001300 P-loop; other site 1150475001301 phosphorylation site [posttranslational modification] 1150475001302 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1150475001303 active site 1150475001304 phosphorylation site [posttranslational modification] 1150475001305 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1150475001306 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1150475001307 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1150475001308 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1150475001309 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1150475001310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475001311 active site 1150475001312 motif I; other site 1150475001313 motif II; other site 1150475001314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475001315 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1150475001316 putative active site [active] 1150475001317 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1150475001318 hypothetical protein; Provisional; Region: PRK05463 1150475001319 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1150475001320 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1150475001321 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1150475001322 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1150475001323 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1150475001324 Bacterial transcriptional regulator; Region: IclR; pfam01614 1150475001325 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1150475001326 active site 1150475001327 catalytic triad [active] 1150475001328 oxyanion hole [active] 1150475001329 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1150475001330 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1150475001331 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1150475001332 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1150475001333 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1150475001334 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1150475001335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475001336 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475001337 active site 1150475001338 catalytic tetrad [active] 1150475001339 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1150475001340 HTH domain; Region: HTH_11; pfam08279 1150475001341 Mga helix-turn-helix domain; Region: Mga; pfam05043 1150475001342 PRD domain; Region: PRD; pfam00874 1150475001343 PRD domain; Region: PRD; pfam00874 1150475001344 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1150475001345 active site 1150475001346 P-loop; other site 1150475001347 phosphorylation site [posttranslational modification] 1150475001348 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1150475001349 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1150475001350 acyl-activating enzyme (AAE) consensus motif; other site 1150475001351 putative AMP binding site [chemical binding]; other site 1150475001352 putative active site [active] 1150475001353 putative CoA binding site [chemical binding]; other site 1150475001354 short chain dehydrogenase; Provisional; Region: PRK06701 1150475001355 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1150475001356 NAD binding site [chemical binding]; other site 1150475001357 metal binding site [ion binding]; metal-binding site 1150475001358 active site 1150475001359 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1150475001360 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1150475001361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1150475001362 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1150475001363 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1150475001364 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1150475001365 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1150475001366 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1150475001367 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1150475001368 putative DNA binding site [nucleotide binding]; other site 1150475001369 putative Zn2+ binding site [ion binding]; other site 1150475001370 AsnC family; Region: AsnC_trans_reg; pfam01037 1150475001371 DNA topoisomerase III; Provisional; Region: PRK07726 1150475001372 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1150475001373 active site 1150475001374 putative interdomain interaction site [polypeptide binding]; other site 1150475001375 putative metal-binding site [ion binding]; other site 1150475001376 putative nucleotide binding site [chemical binding]; other site 1150475001377 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1150475001378 domain I; other site 1150475001379 DNA binding groove [nucleotide binding] 1150475001380 phosphate binding site [ion binding]; other site 1150475001381 domain II; other site 1150475001382 domain III; other site 1150475001383 nucleotide binding site [chemical binding]; other site 1150475001384 catalytic site [active] 1150475001385 domain IV; other site 1150475001386 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1150475001387 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1150475001388 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1150475001389 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1150475001390 metal binding site [ion binding]; metal-binding site 1150475001391 active site 1150475001392 I-site; other site 1150475001393 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1150475001394 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1150475001395 NodB motif; other site 1150475001396 putative active site [active] 1150475001397 putative catalytic site [active] 1150475001398 putative Zn binding site [ion binding]; other site 1150475001399 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1150475001400 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1150475001401 DXD motif; other site 1150475001402 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1150475001403 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1150475001404 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1150475001405 nudix motif; other site 1150475001406 pyruvate oxidase; Provisional; Region: PRK08611 1150475001407 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1150475001408 PYR/PP interface [polypeptide binding]; other site 1150475001409 dimer interface [polypeptide binding]; other site 1150475001410 tetramer interface [polypeptide binding]; other site 1150475001411 TPP binding site [chemical binding]; other site 1150475001412 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1150475001413 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1150475001414 TPP-binding site [chemical binding]; other site 1150475001415 manganese transport protein MntH; Reviewed; Region: PRK00701 1150475001416 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1150475001417 Bacterial SH3 domain; Region: SH3_3; cl17532 1150475001418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1150475001419 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1150475001420 EcsC protein family; Region: EcsC; pfam12787 1150475001421 General stress protein [General function prediction only]; Region: GsiB; COG3729 1150475001422 General stress protein [General function prediction only]; Region: GsiB; COG3729 1150475001423 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1150475001424 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1150475001425 dimanganese center [ion binding]; other site 1150475001426 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1150475001427 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1150475001428 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1150475001429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475001430 putative active site [active] 1150475001431 heme pocket [chemical binding]; other site 1150475001432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475001433 ATP binding site [chemical binding]; other site 1150475001434 Mg2+ binding site [ion binding]; other site 1150475001435 G-X-G motif; other site 1150475001436 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1150475001437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475001438 active site 1150475001439 phosphorylation site [posttranslational modification] 1150475001440 intermolecular recognition site; other site 1150475001441 dimerization interface [polypeptide binding]; other site 1150475001442 HTH domain; Region: HTH_11; pfam08279 1150475001443 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1150475001444 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1150475001445 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1150475001446 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1150475001447 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475001448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475001449 Walker A/P-loop; other site 1150475001450 ATP binding site [chemical binding]; other site 1150475001451 Q-loop/lid; other site 1150475001452 ABC transporter signature motif; other site 1150475001453 Walker B; other site 1150475001454 D-loop; other site 1150475001455 H-loop/switch region; other site 1150475001456 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1150475001457 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1150475001458 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1150475001459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1150475001460 active site 1150475001461 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1150475001462 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1150475001463 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1150475001464 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1150475001465 catalytic residues [active] 1150475001466 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1150475001467 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1150475001468 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1150475001469 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1150475001470 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1150475001471 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1150475001472 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1150475001473 helicase 45; Provisional; Region: PTZ00424 1150475001474 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1150475001475 ATP binding site [chemical binding]; other site 1150475001476 Mg++ binding site [ion binding]; other site 1150475001477 motif III; other site 1150475001478 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475001479 nucleotide binding region [chemical binding]; other site 1150475001480 ATP-binding site [chemical binding]; other site 1150475001481 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1150475001482 Predicted membrane protein [Function unknown]; Region: COG3428 1150475001483 Bacterial PH domain; Region: DUF304; pfam03703 1150475001484 Bacterial PH domain; Region: DUF304; pfam03703 1150475001485 Bacterial PH domain; Region: DUF304; pfam03703 1150475001486 Rhomboid family; Region: Rhomboid; pfam01694 1150475001487 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1150475001488 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1150475001489 alanine racemase; Region: alr; TIGR00492 1150475001490 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1150475001491 active site 1150475001492 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1150475001493 dimer interface [polypeptide binding]; other site 1150475001494 substrate binding site [chemical binding]; other site 1150475001495 catalytic residues [active] 1150475001496 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1150475001497 ribbon-helix-helix domain containing protein; Region: PHA00617 1150475001498 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1150475001499 Rsbr N terminal; Region: Rsbr_N; pfam08678 1150475001500 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1150475001501 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1150475001502 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1150475001503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475001504 ATP binding site [chemical binding]; other site 1150475001505 Mg2+ binding site [ion binding]; other site 1150475001506 G-X-G motif; other site 1150475001507 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1150475001508 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1150475001509 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1150475001510 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1150475001511 anti sigma factor interaction site; other site 1150475001512 regulatory phosphorylation site [posttranslational modification]; other site 1150475001513 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1150475001514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475001515 ATP binding site [chemical binding]; other site 1150475001516 Mg2+ binding site [ion binding]; other site 1150475001517 G-X-G motif; other site 1150475001518 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1150475001519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475001520 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1150475001521 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475001522 DNA binding residues [nucleotide binding] 1150475001523 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1150475001524 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1150475001525 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1150475001526 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1150475001527 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1150475001528 RNA binding site [nucleotide binding]; other site 1150475001529 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1150475001530 hypothetical protein; Provisional; Region: PRK04351 1150475001531 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1150475001532 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1150475001533 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1150475001534 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1150475001535 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1150475001536 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1150475001537 AsnC family; Region: AsnC_trans_reg; pfam01037 1150475001538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1150475001539 proline/glycine betaine transporter; Provisional; Region: PRK10642 1150475001540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001541 putative substrate translocation pore; other site 1150475001542 MarR family; Region: MarR_2; cl17246 1150475001543 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1150475001544 putative active site [active] 1150475001545 putative catalytic site [active] 1150475001546 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1150475001547 Predicted transcriptional regulator [Transcription]; Region: COG1959 1150475001548 Transcriptional regulator; Region: Rrf2; pfam02082 1150475001549 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1150475001550 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1150475001551 NAD binding site [chemical binding]; other site 1150475001552 substrate binding site [chemical binding]; other site 1150475001553 putative active site [active] 1150475001554 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1150475001555 DNA-binding site [nucleotide binding]; DNA binding site 1150475001556 RNA-binding motif; other site 1150475001557 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1150475001558 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1150475001559 aspartate racemase; Region: asp_race; TIGR00035 1150475001560 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1150475001561 Predicted transcriptional regulators [Transcription]; Region: COG1695 1150475001562 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1150475001563 Patatin [General function prediction only]; Region: COG3621 1150475001564 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1150475001565 active site 1150475001566 nucleophile elbow; other site 1150475001567 DinB family; Region: DinB; cl17821 1150475001568 DinB superfamily; Region: DinB_2; pfam12867 1150475001569 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1150475001570 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1150475001571 FAD binding domain; Region: FAD_binding_4; pfam01565 1150475001572 Berberine and berberine like; Region: BBE; pfam08031 1150475001573 Evidence 4 : Homologs of previously reported genes of unknown function 1150475001574 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1150475001575 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1150475001576 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1150475001577 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1150475001578 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1150475001579 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1150475001580 inhibitor site; inhibition site 1150475001581 active site 1150475001582 dimer interface [polypeptide binding]; other site 1150475001583 catalytic residue [active] 1150475001584 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 1150475001585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475001586 FeS/SAM binding site; other site 1150475001587 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1150475001588 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1150475001589 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1150475001590 dimerization interface [polypeptide binding]; other site 1150475001591 active site 1150475001592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475001593 S-adenosylmethionine binding site [chemical binding]; other site 1150475001594 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1150475001595 dimer interface [polypeptide binding]; other site 1150475001596 substrate binding site [chemical binding]; other site 1150475001597 ATP binding site [chemical binding]; other site 1150475001598 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1150475001599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475001600 active site 1150475001601 motif I; other site 1150475001602 motif II; other site 1150475001603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475001604 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1150475001605 nudix motif; other site 1150475001606 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1150475001607 Sodium Bile acid symporter family; Region: SBF; cl17470 1150475001608 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1150475001609 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1150475001610 putative NAD(P) binding site [chemical binding]; other site 1150475001611 putative substrate binding site [chemical binding]; other site 1150475001612 catalytic Zn binding site [ion binding]; other site 1150475001613 structural Zn binding site [ion binding]; other site 1150475001614 dimer interface [polypeptide binding]; other site 1150475001615 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1150475001616 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1150475001617 DNA binding residues [nucleotide binding] 1150475001618 putative dimer interface [polypeptide binding]; other site 1150475001619 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1150475001620 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1150475001621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475001622 DNA-binding site [nucleotide binding]; DNA binding site 1150475001623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475001624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475001625 homodimer interface [polypeptide binding]; other site 1150475001626 catalytic residue [active] 1150475001627 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1150475001628 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475001629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475001631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475001632 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1150475001633 EamA-like transporter family; Region: EamA; cl17759 1150475001634 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1150475001635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475001636 DNA-binding site [nucleotide binding]; DNA binding site 1150475001637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475001638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475001639 homodimer interface [polypeptide binding]; other site 1150475001640 catalytic residue [active] 1150475001641 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1150475001642 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1150475001643 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1150475001644 NAD binding site [chemical binding]; other site 1150475001645 catalytic Zn binding site [ion binding]; other site 1150475001646 structural Zn binding site [ion binding]; other site 1150475001647 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1150475001648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1150475001649 Histidine kinase; Region: HisKA_3; pfam07730 1150475001650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475001651 ATP binding site [chemical binding]; other site 1150475001652 Mg2+ binding site [ion binding]; other site 1150475001653 G-X-G motif; other site 1150475001654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475001655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475001656 active site 1150475001657 phosphorylation site [posttranslational modification] 1150475001658 intermolecular recognition site; other site 1150475001659 dimerization interface [polypeptide binding]; other site 1150475001660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475001661 DNA binding residues [nucleotide binding] 1150475001662 dimerization interface [polypeptide binding]; other site 1150475001663 MMPL family; Region: MMPL; pfam03176 1150475001664 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1150475001665 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1150475001666 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1150475001667 catalytic triad [active] 1150475001668 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1150475001669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475001670 ABC transporter; Region: ABC_tran_2; pfam12848 1150475001671 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475001672 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1150475001673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475001674 Coenzyme A binding pocket [chemical binding]; other site 1150475001675 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1150475001676 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475001677 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475001678 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1150475001679 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1150475001680 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1150475001681 dimer interface [polypeptide binding]; other site 1150475001682 active site 1150475001683 metal binding site [ion binding]; metal-binding site 1150475001684 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1150475001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001686 putative substrate translocation pore; other site 1150475001687 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1150475001688 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1150475001689 dimer interface [polypeptide binding]; other site 1150475001690 active site 1150475001691 Helix-turn-helix domain; Region: HTH_31; pfam13560 1150475001692 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1150475001693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1150475001694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475001695 Coenzyme A binding pocket [chemical binding]; other site 1150475001696 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator 1150475001697 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1150475001698 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1150475001699 nudix motif; other site 1150475001700 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1150475001701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475001702 S-adenosylmethionine binding site [chemical binding]; other site 1150475001703 tartrate dehydrogenase; Provisional; Region: PRK08194 1150475001704 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1150475001705 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1150475001706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475001707 DNA-binding site [nucleotide binding]; DNA binding site 1150475001708 FCD domain; Region: FCD; pfam07729 1150475001709 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1150475001710 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1150475001711 active site 1150475001712 TDP-binding site; other site 1150475001713 acceptor substrate-binding pocket; other site 1150475001714 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1150475001715 Beta-lactamase; Region: Beta-lactamase; pfam00144 1150475001716 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1150475001717 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1150475001718 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1150475001719 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475001720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001721 putative substrate translocation pore; other site 1150475001722 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1150475001723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475001724 DNA-binding site [nucleotide binding]; DNA binding site 1150475001725 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1150475001726 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1150475001727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475001728 DNA-binding site [nucleotide binding]; DNA binding site 1150475001729 FCD domain; Region: FCD; pfam07729 1150475001730 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1150475001731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001732 putative substrate translocation pore; other site 1150475001733 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1150475001734 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1150475001735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475001736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475001737 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1150475001738 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1150475001739 dimanganese center [ion binding]; other site 1150475001740 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1150475001741 putative hydrophobic ligand binding site [chemical binding]; other site 1150475001742 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1150475001743 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1150475001744 putative NADP binding site [chemical binding]; other site 1150475001745 putative dimer interface [polypeptide binding]; other site 1150475001746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001747 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1150475001748 putative substrate translocation pore; other site 1150475001749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001750 thiamine monophosphate kinase; Provisional; Region: PRK05731 1150475001751 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1150475001752 ATP binding site [chemical binding]; other site 1150475001753 dimerization interface [polypeptide binding]; other site 1150475001754 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1150475001755 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1150475001756 Glycoprotease family; Region: Peptidase_M22; pfam00814 1150475001757 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1150475001758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475001759 Coenzyme A binding pocket [chemical binding]; other site 1150475001760 UGMP family protein; Validated; Region: PRK09604 1150475001761 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1150475001762 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1150475001763 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1150475001764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475001765 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475001766 ABC transporter; Region: ABC_tran_2; pfam12848 1150475001767 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475001768 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1150475001769 trimer interface [polypeptide binding]; other site 1150475001770 dimer interface [polypeptide binding]; other site 1150475001771 putative active site [active] 1150475001772 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1150475001773 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1150475001774 CoA binding domain; Region: CoA_binding; pfam02629 1150475001775 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1150475001776 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1150475001777 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1150475001778 CAAX protease self-immunity; Region: Abi; pfam02517 1150475001779 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1150475001780 oligomerisation interface [polypeptide binding]; other site 1150475001781 mobile loop; other site 1150475001782 roof hairpin; other site 1150475001783 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1150475001784 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1150475001785 ring oligomerisation interface [polypeptide binding]; other site 1150475001786 ATP/Mg binding site [chemical binding]; other site 1150475001787 stacking interactions; other site 1150475001788 hinge regions; other site 1150475001789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475001790 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1150475001791 Walker A motif; other site 1150475001792 ATP binding site [chemical binding]; other site 1150475001793 Walker B motif; other site 1150475001794 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475001795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475001796 binding surface 1150475001797 TPR motif; other site 1150475001798 TPR repeat; Region: TPR_11; pfam13414 1150475001799 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1150475001800 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1150475001801 inhibitor binding site; inhibition site 1150475001802 catalytic Zn binding site [ion binding]; other site 1150475001803 structural Zn binding site [ion binding]; other site 1150475001804 NADP binding site [chemical binding]; other site 1150475001805 tetramer interface [polypeptide binding]; other site 1150475001806 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1150475001807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475001808 putative substrate translocation pore; other site 1150475001809 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1150475001810 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1150475001811 putative substrate binding site [chemical binding]; other site 1150475001812 putative ATP binding site [chemical binding]; other site 1150475001813 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1150475001814 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1150475001815 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1150475001816 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1150475001817 Repair protein; Region: Repair_PSII; pfam04536 1150475001818 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1150475001819 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1150475001820 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1150475001821 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1150475001822 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1150475001823 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1150475001824 catalytic triad [active] 1150475001825 catalytic triad [active] 1150475001826 oxyanion hole [active] 1150475001827 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1150475001828 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1150475001829 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1150475001830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475001831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475001832 DNA binding residues [nucleotide binding] 1150475001833 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1150475001834 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1150475001835 putative NAD(P) binding site [chemical binding]; other site 1150475001836 catalytic Zn binding site [ion binding]; other site 1150475001837 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1150475001838 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1150475001839 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1150475001840 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1150475001841 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1150475001842 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1150475001843 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1150475001844 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1150475001845 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1150475001846 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1150475001847 MoxR-like ATPases [General function prediction only]; Region: COG0714 1150475001848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475001849 Walker A motif; other site 1150475001850 ATP binding site [chemical binding]; other site 1150475001851 Walker B motif; other site 1150475001852 arginine finger; other site 1150475001853 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1150475001854 Protein of unknown function DUF58; Region: DUF58; pfam01882 1150475001855 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1150475001856 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1150475001857 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1150475001858 GMP synthase; Reviewed; Region: guaA; PRK00074 1150475001859 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1150475001860 AMP/PPi binding site [chemical binding]; other site 1150475001861 candidate oxyanion hole; other site 1150475001862 catalytic triad [active] 1150475001863 potential glutamine specificity residues [chemical binding]; other site 1150475001864 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1150475001865 ATP Binding subdomain [chemical binding]; other site 1150475001866 Ligand Binding sites [chemical binding]; other site 1150475001867 Dimerization subdomain; other site 1150475001868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475001869 Coenzyme A binding pocket [chemical binding]; other site 1150475001870 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1150475001871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475001872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475001873 DNA binding residues [nucleotide binding] 1150475001874 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1150475001875 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1150475001876 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1150475001877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1150475001878 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1150475001879 NETI protein; Region: NETI; pfam14044 1150475001880 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1150475001881 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1150475001882 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1150475001883 NAD binding site [chemical binding]; other site 1150475001884 ATP-grasp domain; Region: ATP-grasp; pfam02222 1150475001885 adenylosuccinate lyase; Provisional; Region: PRK07492 1150475001886 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1150475001887 tetramer interface [polypeptide binding]; other site 1150475001888 active site 1150475001889 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1150475001890 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1150475001891 ATP binding site [chemical binding]; other site 1150475001892 active site 1150475001893 substrate binding site [chemical binding]; other site 1150475001894 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1150475001895 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1150475001896 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1150475001897 putative active site [active] 1150475001898 catalytic triad [active] 1150475001899 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1150475001900 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1150475001901 dimerization interface [polypeptide binding]; other site 1150475001902 ATP binding site [chemical binding]; other site 1150475001903 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1150475001904 dimerization interface [polypeptide binding]; other site 1150475001905 ATP binding site [chemical binding]; other site 1150475001906 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1150475001907 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1150475001908 active site 1150475001909 tetramer interface [polypeptide binding]; other site 1150475001910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475001911 active site 1150475001912 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1150475001913 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1150475001914 dimerization interface [polypeptide binding]; other site 1150475001915 putative ATP binding site [chemical binding]; other site 1150475001916 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1150475001917 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1150475001918 active site 1150475001919 substrate binding site [chemical binding]; other site 1150475001920 cosubstrate binding site; other site 1150475001921 catalytic site [active] 1150475001922 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1150475001923 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1150475001924 purine monophosphate binding site [chemical binding]; other site 1150475001925 dimer interface [polypeptide binding]; other site 1150475001926 putative catalytic residues [active] 1150475001927 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1150475001928 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1150475001929 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1150475001930 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1150475001931 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1150475001932 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1150475001933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1150475001934 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1150475001935 active site 1150475001936 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1150475001937 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1150475001938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1150475001939 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1150475001940 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1150475001941 active site 1150475001942 FMN binding site [chemical binding]; other site 1150475001943 substrate binding site [chemical binding]; other site 1150475001944 3Fe-4S cluster binding site [ion binding]; other site 1150475001945 PcrB family; Region: PcrB; pfam01884 1150475001946 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1150475001947 substrate binding site [chemical binding]; other site 1150475001948 putative active site [active] 1150475001949 dimer interface [polypeptide binding]; other site 1150475001950 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1150475001951 Part of AAA domain; Region: AAA_19; pfam13245 1150475001952 Family description; Region: UvrD_C_2; pfam13538 1150475001953 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1150475001954 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1150475001955 nucleotide binding pocket [chemical binding]; other site 1150475001956 K-X-D-G motif; other site 1150475001957 catalytic site [active] 1150475001958 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1150475001959 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1150475001960 Helix-hairpin-helix motif; Region: HHH; pfam00633 1150475001961 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1150475001962 Dimer interface [polypeptide binding]; other site 1150475001963 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1150475001964 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1150475001965 putative dimer interface [polypeptide binding]; other site 1150475001966 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1150475001967 putative dimer interface [polypeptide binding]; other site 1150475001968 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1150475001969 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1150475001970 active site 1150475001971 ATP binding site [chemical binding]; other site 1150475001972 substrate binding site [chemical binding]; other site 1150475001973 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1150475001974 MgtC family; Region: MgtC; pfam02308 1150475001975 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1150475001976 Na binding site [ion binding]; other site 1150475001977 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1150475001978 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1150475001979 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1150475001980 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1150475001981 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1150475001982 GatB domain; Region: GatB_Yqey; pfam02637 1150475001983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475001984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475001985 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1150475001986 Protein export membrane protein; Region: SecD_SecF; cl14618 1150475001987 putative lipid kinase; Reviewed; Region: PRK13337 1150475001988 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1150475001989 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1150475001990 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1150475001991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475001992 S-adenosylmethionine binding site [chemical binding]; other site 1150475001993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475001994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475001995 Walker A/P-loop; other site 1150475001996 ATP binding site [chemical binding]; other site 1150475001997 Q-loop/lid; other site 1150475001998 ABC transporter signature motif; other site 1150475001999 Walker B; other site 1150475002000 D-loop; other site 1150475002001 H-loop/switch region; other site 1150475002002 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1150475002003 Protein of unknown function, DUF600; Region: DUF600; cl04640 1150475002004 LXG domain of WXG superfamily; Region: LXG; pfam04740 1150475002005 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1150475002006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 1150475002007 hypothetical protein; Provisional; Region: PRK12378 1150475002008 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1150475002009 CotJB protein; Region: CotJB; pfam12652 1150475002010 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1150475002011 dimanganese center [ion binding]; other site 1150475002012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475002013 Coenzyme A binding pocket [chemical binding]; other site 1150475002014 YesK-like protein; Region: YesK; pfam14150 1150475002015 Predicted membrane protein [Function unknown]; Region: COG2323 1150475002016 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1150475002017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475002018 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1150475002019 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1150475002020 Uncharacterized small protein [Function unknown]; Region: COG5583 1150475002021 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1150475002022 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1150475002023 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475002024 MarR family; Region: MarR; pfam01047 1150475002025 hypothetical protein; Provisional; Region: PRK06847 1150475002026 hypothetical protein; Provisional; Region: PRK07236 1150475002027 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1150475002028 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1150475002029 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1150475002030 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1150475002031 Cytochrome P450; Region: p450; pfam00067 1150475002032 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1150475002033 Flavodoxin; Region: Flavodoxin_1; pfam00258 1150475002034 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1150475002035 FAD binding pocket [chemical binding]; other site 1150475002036 FAD binding motif [chemical binding]; other site 1150475002037 catalytic residues [active] 1150475002038 NAD binding pocket [chemical binding]; other site 1150475002039 phosphate binding motif [ion binding]; other site 1150475002040 beta-alpha-beta structure motif; other site 1150475002041 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1150475002042 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475002043 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1150475002044 Walker A/P-loop; other site 1150475002045 ATP binding site [chemical binding]; other site 1150475002046 Q-loop/lid; other site 1150475002047 ABC transporter signature motif; other site 1150475002048 Walker B; other site 1150475002049 D-loop; other site 1150475002050 H-loop/switch region; other site 1150475002051 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1150475002052 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1150475002053 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1150475002054 Sulfatase; Region: Sulfatase; pfam00884 1150475002055 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1150475002056 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1150475002057 substrate binding site; other site 1150475002058 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1150475002059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475002060 NAD(P) binding site [chemical binding]; other site 1150475002061 active site 1150475002062 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1150475002063 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1150475002064 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1150475002065 active site 1150475002066 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1150475002067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475002069 putative substrate translocation pore; other site 1150475002070 amino acid transporter; Region: 2A0306; TIGR00909 1150475002071 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1150475002072 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1150475002073 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1150475002074 NAD(P) binding site [chemical binding]; other site 1150475002075 catalytic residues [active] 1150475002076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475002077 dimer interface [polypeptide binding]; other site 1150475002078 putative CheW interface [polypeptide binding]; other site 1150475002079 oxidoreductase; Provisional; Region: PRK07985 1150475002080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475002081 NAD(P) binding site [chemical binding]; other site 1150475002082 active site 1150475002083 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1150475002084 putative metal binding site; other site 1150475002085 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1150475002086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475002087 Walker A/P-loop; other site 1150475002088 ATP binding site [chemical binding]; other site 1150475002089 Q-loop/lid; other site 1150475002090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475002091 ABC transporter signature motif; other site 1150475002092 Walker B; other site 1150475002093 D-loop; other site 1150475002094 ABC transporter; Region: ABC_tran_2; pfam12848 1150475002095 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475002096 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1150475002097 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1150475002098 DNA binding residues [nucleotide binding] 1150475002099 putative dimer interface [polypeptide binding]; other site 1150475002100 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475002101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002102 putative substrate translocation pore; other site 1150475002103 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1150475002104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475002105 Walker A/P-loop; other site 1150475002106 ATP binding site [chemical binding]; other site 1150475002107 Q-loop/lid; other site 1150475002108 ABC transporter signature motif; other site 1150475002109 Walker B; other site 1150475002110 D-loop; other site 1150475002111 H-loop/switch region; other site 1150475002112 ABC transporter; Region: ABC_tran_2; pfam12848 1150475002113 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475002114 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1150475002115 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1150475002116 ATP binding site [chemical binding]; other site 1150475002117 Mg++ binding site [ion binding]; other site 1150475002118 motif III; other site 1150475002119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475002120 nucleotide binding region [chemical binding]; other site 1150475002121 ATP-binding site [chemical binding]; other site 1150475002122 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1150475002123 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1150475002124 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1150475002125 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1150475002126 NAD(P) binding site [chemical binding]; other site 1150475002127 substrate binding site [chemical binding]; other site 1150475002128 dimer interface [polypeptide binding]; other site 1150475002129 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1150475002130 Heat induced stress protein YflT; Region: YflT; pfam11181 1150475002131 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1150475002132 Amb_all domain; Region: Amb_all; smart00656 1150475002133 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1150475002134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1150475002135 transmembrane helices; other site 1150475002136 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1150475002137 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1150475002138 PAS domain; Region: PAS; smart00091 1150475002139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475002140 ATP binding site [chemical binding]; other site 1150475002141 Mg2+ binding site [ion binding]; other site 1150475002142 G-X-G motif; other site 1150475002143 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1150475002144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475002145 active site 1150475002146 phosphorylation site [posttranslational modification] 1150475002147 intermolecular recognition site; other site 1150475002148 dimerization interface [polypeptide binding]; other site 1150475002149 Transcriptional regulator; Region: CitT; pfam12431 1150475002150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1150475002151 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1150475002152 Citrate transporter; Region: CitMHS; pfam03600 1150475002153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1150475002154 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1150475002155 active site 1150475002156 dimer interface [polypeptide binding]; other site 1150475002157 acylphosphatase; Provisional; Region: PRK14420 1150475002158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1150475002159 MOSC domain; Region: MOSC; pfam03473 1150475002160 3-alpha domain; Region: 3-alpha; pfam03475 1150475002161 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1150475002162 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1150475002163 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1150475002164 active site 1150475002165 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1150475002166 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1150475002167 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1150475002168 active site turn [active] 1150475002169 phosphorylation site [posttranslational modification] 1150475002170 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1150475002171 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1150475002172 Sulfatase; Region: Sulfatase; pfam00884 1150475002173 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1150475002174 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1150475002175 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1150475002176 putative dimer interface [polypeptide binding]; other site 1150475002177 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1150475002178 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1150475002179 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1150475002180 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1150475002181 active site turn [active] 1150475002182 phosphorylation site [posttranslational modification] 1150475002183 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1150475002184 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1150475002185 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1150475002186 Ca binding site [ion binding]; other site 1150475002187 active site 1150475002188 catalytic site [active] 1150475002189 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1150475002190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475002191 DNA-binding site [nucleotide binding]; DNA binding site 1150475002192 UTRA domain; Region: UTRA; pfam07702 1150475002193 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1150475002194 dimer interface [polypeptide binding]; other site 1150475002195 FMN binding site [chemical binding]; other site 1150475002196 YibE/F-like protein; Region: YibE_F; pfam07907 1150475002197 YibE/F-like protein; Region: YibE_F; pfam07907 1150475002198 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1150475002199 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1150475002200 active site 1150475002201 metal binding site [ion binding]; metal-binding site 1150475002202 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1150475002203 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1150475002204 active site 1150475002205 metal binding site [ion binding]; metal-binding site 1150475002206 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1150475002207 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1150475002208 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1150475002209 proposed catalytic triad [active] 1150475002210 conserved cys residue [active] 1150475002211 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475002212 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475002213 DNA binding site [nucleotide binding] 1150475002214 domain linker motif; other site 1150475002215 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1150475002216 putative dimerization interface [polypeptide binding]; other site 1150475002217 putative ligand binding site [chemical binding]; other site 1150475002218 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1150475002219 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1150475002220 shikimate binding site; other site 1150475002221 NAD(P) binding site [chemical binding]; other site 1150475002222 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1150475002223 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1150475002224 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1150475002225 shikimate binding site; other site 1150475002226 NAD(P) binding site [chemical binding]; other site 1150475002227 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1150475002228 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1150475002229 active site 1150475002230 catalytic residue [active] 1150475002231 dimer interface [polypeptide binding]; other site 1150475002232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475002234 putative substrate translocation pore; other site 1150475002235 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1150475002236 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1150475002237 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1150475002238 active site 1150475002239 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 1150475002240 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1150475002241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475002243 putative substrate translocation pore; other site 1150475002244 calcium/proton exchanger (cax); Region: cax; TIGR00378 1150475002245 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1150475002246 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1150475002247 YfkD-like protein; Region: YfkD; pfam14167 1150475002248 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1150475002249 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1150475002250 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1150475002251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475002252 FeS/SAM binding site; other site 1150475002253 YfkB-like domain; Region: YfkB; pfam08756 1150475002254 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1150475002255 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1150475002256 NodB motif; other site 1150475002257 active site 1150475002258 catalytic site [active] 1150475002259 Cd binding site [ion binding]; other site 1150475002260 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1150475002261 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1150475002262 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1150475002263 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1150475002264 oligomer interface [polypeptide binding]; other site 1150475002265 metal binding site [ion binding]; metal-binding site 1150475002266 metal binding site [ion binding]; metal-binding site 1150475002267 putative Cl binding site [ion binding]; other site 1150475002268 aspartate ring; other site 1150475002269 basic sphincter; other site 1150475002270 hydrophobic gate; other site 1150475002271 periplasmic entrance; other site 1150475002272 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1150475002273 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1150475002274 minor groove reading motif; other site 1150475002275 helix-hairpin-helix signature motif; other site 1150475002276 substrate binding pocket [chemical binding]; other site 1150475002277 active site 1150475002278 TRAM domain; Region: TRAM; pfam01938 1150475002279 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1150475002280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475002281 S-adenosylmethionine binding site [chemical binding]; other site 1150475002282 YfzA-like protein; Region: YfzA; pfam14118 1150475002283 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1150475002284 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1150475002285 FMN binding site [chemical binding]; other site 1150475002286 active site 1150475002287 catalytic residues [active] 1150475002288 substrate binding site [chemical binding]; other site 1150475002289 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1150475002290 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1150475002291 tetramer interface [polypeptide binding]; other site 1150475002292 TPP-binding site [chemical binding]; other site 1150475002293 heterodimer interface [polypeptide binding]; other site 1150475002294 phosphorylation loop region [posttranslational modification] 1150475002295 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1150475002296 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1150475002297 alpha subunit interface [polypeptide binding]; other site 1150475002298 TPP binding site [chemical binding]; other site 1150475002299 heterodimer interface [polypeptide binding]; other site 1150475002300 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1150475002301 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1150475002302 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1150475002303 E3 interaction surface; other site 1150475002304 lipoyl attachment site [posttranslational modification]; other site 1150475002305 e3 binding domain; Region: E3_binding; pfam02817 1150475002306 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1150475002307 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1150475002308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475002309 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1150475002310 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1150475002311 GAF domain; Region: GAF; pfam01590 1150475002312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475002313 Walker A motif; other site 1150475002314 ATP binding site [chemical binding]; other site 1150475002315 Walker B motif; other site 1150475002316 arginine finger; other site 1150475002317 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1150475002318 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1150475002319 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1150475002320 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1150475002321 NAD binding site [chemical binding]; other site 1150475002322 sugar binding site [chemical binding]; other site 1150475002323 divalent metal binding site [ion binding]; other site 1150475002324 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1150475002325 dimer interface [polypeptide binding]; other site 1150475002326 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1150475002327 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1150475002328 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1150475002329 putative active site [active] 1150475002330 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1150475002331 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1150475002332 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1150475002333 active site turn [active] 1150475002334 phosphorylation site [posttranslational modification] 1150475002335 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1150475002336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475002337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475002338 Walker A/P-loop; other site 1150475002339 ATP binding site [chemical binding]; other site 1150475002340 Q-loop/lid; other site 1150475002341 ABC transporter signature motif; other site 1150475002342 Walker B; other site 1150475002343 D-loop; other site 1150475002344 H-loop/switch region; other site 1150475002345 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1150475002346 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475002347 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1150475002348 Walker A/P-loop; other site 1150475002349 ATP binding site [chemical binding]; other site 1150475002350 Q-loop/lid; other site 1150475002351 ABC transporter signature motif; other site 1150475002352 Walker B; other site 1150475002353 D-loop; other site 1150475002354 H-loop/switch region; other site 1150475002355 Predicted membrane protein [Function unknown]; Region: COG2259 1150475002356 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1150475002357 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1150475002358 putative metal binding site [ion binding]; other site 1150475002359 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1150475002360 active site 1150475002361 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1150475002362 UbiA prenyltransferase family; Region: UbiA; pfam01040 1150475002363 Predicted transcriptional regulators [Transcription]; Region: COG1695 1150475002364 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1150475002365 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1150475002366 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1150475002367 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1150475002368 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1150475002369 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1150475002370 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1150475002371 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1150475002372 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1150475002373 RNAase interaction site [polypeptide binding]; other site 1150475002374 metal-dependent hydrolase; Provisional; Region: PRK13291 1150475002375 DinB superfamily; Region: DinB_2; pfam12867 1150475002376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002377 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475002378 putative substrate translocation pore; other site 1150475002379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002380 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475002381 MarR family; Region: MarR; pfam01047 1150475002382 Predicted integral membrane protein [Function unknown]; Region: COG0392 1150475002383 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1150475002384 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1150475002385 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1150475002386 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1150475002387 putative FMN binding site [chemical binding]; other site 1150475002388 YfhD-like protein; Region: YfhD; pfam14151 1150475002389 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1150475002390 TIGR01777 family protein; Region: yfcH 1150475002391 putative NAD(P) binding site [chemical binding]; other site 1150475002392 putative active site [active] 1150475002393 recombination regulator RecX; Provisional; Region: recX; PRK14135 1150475002394 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1150475002395 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475002396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002397 putative substrate translocation pore; other site 1150475002398 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1150475002399 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1150475002400 WVELL protein; Region: WVELL; pfam14043 1150475002401 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1150475002402 Bacterial SH3 domain; Region: SH3_3; cl17532 1150475002403 SdpI/YhfL protein family; Region: SdpI; pfam13630 1150475002404 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1150475002405 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1150475002406 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1150475002407 Ligand binding site; other site 1150475002408 Putative Catalytic site; other site 1150475002409 DXD motif; other site 1150475002410 Predicted membrane protein [Function unknown]; Region: COG4485 1150475002411 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1150475002412 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1150475002413 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1150475002414 minor groove reading motif; other site 1150475002415 helix-hairpin-helix signature motif; other site 1150475002416 substrate binding pocket [chemical binding]; other site 1150475002417 active site 1150475002418 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1150475002419 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1150475002420 DNA binding and oxoG recognition site [nucleotide binding] 1150475002421 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1150475002422 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1150475002423 putative NAD(P) binding site [chemical binding]; other site 1150475002424 active site 1150475002425 YgaB-like protein; Region: YgaB; pfam14182 1150475002426 hypothetical protein; Provisional; Region: PRK13662 1150475002427 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1150475002428 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475002429 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1150475002430 Walker A/P-loop; other site 1150475002431 ATP binding site [chemical binding]; other site 1150475002432 Q-loop/lid; other site 1150475002433 ABC transporter signature motif; other site 1150475002434 Walker B; other site 1150475002435 D-loop; other site 1150475002436 H-loop/switch region; other site 1150475002437 Predicted membrane protein [Function unknown]; Region: COG4129 1150475002438 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1150475002439 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1150475002440 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475002441 inhibitor-cofactor binding pocket; inhibition site 1150475002442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475002443 catalytic residue [active] 1150475002444 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1150475002445 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1150475002446 catalytic triad [active] 1150475002447 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1150475002448 metal binding site 2 [ion binding]; metal-binding site 1150475002449 putative DNA binding helix; other site 1150475002450 metal binding site 1 [ion binding]; metal-binding site 1150475002451 dimer interface [polypeptide binding]; other site 1150475002452 structural Zn2+ binding site [ion binding]; other site 1150475002453 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1150475002454 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1150475002455 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1150475002456 cofactor binding site; other site 1150475002457 DNA binding site [nucleotide binding] 1150475002458 substrate interaction site [chemical binding]; other site 1150475002459 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 1150475002460 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1150475002461 metal binding site [ion binding]; metal-binding site 1150475002462 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1150475002463 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1150475002464 active site pocket [active] 1150475002465 oxyanion hole [active] 1150475002466 catalytic triad [active] 1150475002467 active site nucleophile [active] 1150475002468 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1150475002469 ThiC-associated domain; Region: ThiC-associated; pfam13667 1150475002470 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1150475002471 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1150475002472 FAD binding domain; Region: FAD_binding_4; pfam01565 1150475002473 Berberine and berberine like; Region: BBE; pfam08031 1150475002474 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1150475002475 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1150475002476 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1150475002477 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1150475002478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475002479 dimer interface [polypeptide binding]; other site 1150475002480 conserved gate region; other site 1150475002481 putative PBP binding loops; other site 1150475002482 ABC-ATPase subunit interface; other site 1150475002483 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1150475002484 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1150475002485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475002486 dimer interface [polypeptide binding]; other site 1150475002487 conserved gate region; other site 1150475002488 putative PBP binding loops; other site 1150475002489 ABC-ATPase subunit interface; other site 1150475002490 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1150475002491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1150475002492 Walker A/P-loop; other site 1150475002493 ATP binding site [chemical binding]; other site 1150475002494 Q-loop/lid; other site 1150475002495 ABC transporter signature motif; other site 1150475002496 Walker B; other site 1150475002497 D-loop; other site 1150475002498 H-loop/switch region; other site 1150475002499 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1150475002500 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1150475002501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1150475002502 Walker A/P-loop; other site 1150475002503 ATP binding site [chemical binding]; other site 1150475002504 Q-loop/lid; other site 1150475002505 ABC transporter signature motif; other site 1150475002506 Walker B; other site 1150475002507 D-loop; other site 1150475002508 H-loop/switch region; other site 1150475002509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1150475002510 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1150475002511 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1150475002512 tetramer interface [polypeptide binding]; other site 1150475002513 heme binding pocket [chemical binding]; other site 1150475002514 NADPH binding site [chemical binding]; other site 1150475002515 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1150475002516 active site 1150475002517 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1150475002518 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1150475002519 Walker A/P-loop; other site 1150475002520 ATP binding site [chemical binding]; other site 1150475002521 Q-loop/lid; other site 1150475002522 ABC transporter signature motif; other site 1150475002523 Walker B; other site 1150475002524 D-loop; other site 1150475002525 H-loop/switch region; other site 1150475002526 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1150475002527 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1150475002528 substrate binding pocket [chemical binding]; other site 1150475002529 membrane-bound complex binding site; other site 1150475002530 hinge residues; other site 1150475002531 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1150475002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475002533 dimer interface [polypeptide binding]; other site 1150475002534 conserved gate region; other site 1150475002535 putative PBP binding loops; other site 1150475002536 ABC-ATPase subunit interface; other site 1150475002537 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1150475002538 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1150475002539 active site 1150475002540 dimer interface [polypeptide binding]; other site 1150475002541 non-prolyl cis peptide bond; other site 1150475002542 insertion regions; other site 1150475002543 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1150475002544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475002545 non-specific DNA binding site [nucleotide binding]; other site 1150475002546 salt bridge; other site 1150475002547 sequence-specific DNA binding site [nucleotide binding]; other site 1150475002548 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1150475002549 epoxyqueuosine reductase; Region: TIGR00276 1150475002550 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1150475002551 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1150475002552 Putative amidase domain; Region: Amidase_6; pfam12671 1150475002553 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1150475002554 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1150475002555 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1150475002556 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1150475002557 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1150475002558 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1150475002559 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1150475002560 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1150475002561 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475002562 MarR family; Region: MarR; pfam01047 1150475002563 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1150475002564 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1150475002565 carboxyltransferase (CT) interaction site; other site 1150475002566 biotinylation site [posttranslational modification]; other site 1150475002567 HlyD family secretion protein; Region: HlyD_3; pfam13437 1150475002568 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1150475002569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002570 putative substrate translocation pore; other site 1150475002571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475002572 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1150475002573 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1150475002574 Predicted transcriptional regulators [Transcription]; Region: COG1725 1150475002575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475002576 DNA-binding site [nucleotide binding]; DNA binding site 1150475002577 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1150475002578 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1150475002579 Walker A/P-loop; other site 1150475002580 ATP binding site [chemical binding]; other site 1150475002581 Q-loop/lid; other site 1150475002582 ABC transporter signature motif; other site 1150475002583 Walker B; other site 1150475002584 D-loop; other site 1150475002585 H-loop/switch region; other site 1150475002586 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475002587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475002588 Walker A/P-loop; other site 1150475002589 ATP binding site [chemical binding]; other site 1150475002590 Q-loop/lid; other site 1150475002591 ABC transporter signature motif; other site 1150475002592 Walker B; other site 1150475002593 D-loop; other site 1150475002594 H-loop/switch region; other site 1150475002595 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1150475002596 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1150475002597 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1150475002598 DNA-binding site [nucleotide binding]; DNA binding site 1150475002599 RNA-binding motif; other site 1150475002600 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1150475002601 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1150475002602 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1150475002603 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1150475002604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1150475002605 metal binding site [ion binding]; metal-binding site 1150475002606 active site 1150475002607 I-site; other site 1150475002608 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1150475002609 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1150475002610 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1150475002611 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1150475002612 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1150475002613 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1150475002614 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1150475002615 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1150475002616 putative active site [active] 1150475002617 putative metal binding site [ion binding]; other site 1150475002618 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1150475002619 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 1150475002620 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1150475002621 active site 1150475002622 catalytic site [active] 1150475002623 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1150475002624 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1150475002625 active site 1150475002626 FOG: CBS domain [General function prediction only]; Region: COG0517 1150475002627 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1150475002628 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1150475002629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475002630 motif II; other site 1150475002631 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1150475002632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475002633 Coenzyme A binding pocket [chemical binding]; other site 1150475002634 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1150475002635 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1150475002636 putative active site [active] 1150475002637 catalytic triad [active] 1150475002638 putative dimer interface [polypeptide binding]; other site 1150475002639 aminotransferase; Validated; Region: PRK07678 1150475002640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475002641 inhibitor-cofactor binding pocket; inhibition site 1150475002642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475002643 catalytic residue [active] 1150475002644 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1150475002645 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1150475002646 amphipathic channel; other site 1150475002647 Asn-Pro-Ala signature motifs; other site 1150475002648 glycerol kinase; Provisional; Region: glpK; PRK00047 1150475002649 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1150475002650 N- and C-terminal domain interface [polypeptide binding]; other site 1150475002651 active site 1150475002652 MgATP binding site [chemical binding]; other site 1150475002653 catalytic site [active] 1150475002654 metal binding site [ion binding]; metal-binding site 1150475002655 glycerol binding site [chemical binding]; other site 1150475002656 homotetramer interface [polypeptide binding]; other site 1150475002657 homodimer interface [polypeptide binding]; other site 1150475002658 FBP binding site [chemical binding]; other site 1150475002659 protein IIAGlc interface [polypeptide binding]; other site 1150475002660 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1150475002661 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1150475002662 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1150475002663 active site 1150475002664 substrate binding site [chemical binding]; other site 1150475002665 metal binding site [ion binding]; metal-binding site 1150475002666 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1150475002667 GAF domain; Region: GAF; pfam01590 1150475002668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1150475002669 Histidine kinase; Region: HisKA_3; pfam07730 1150475002670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475002671 ATP binding site [chemical binding]; other site 1150475002672 Mg2+ binding site [ion binding]; other site 1150475002673 G-X-G motif; other site 1150475002674 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475002675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475002676 active site 1150475002677 phosphorylation site [posttranslational modification] 1150475002678 intermolecular recognition site; other site 1150475002679 dimerization interface [polypeptide binding]; other site 1150475002680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475002681 DNA binding residues [nucleotide binding] 1150475002682 dimerization interface [polypeptide binding]; other site 1150475002683 Predicted flavoprotein [General function prediction only]; Region: COG0431 1150475002684 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1150475002685 YhdB-like protein; Region: YhdB; pfam14148 1150475002686 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1150475002687 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475002688 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475002689 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475002690 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475002691 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475002692 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475002693 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1150475002694 NlpC/P60 family; Region: NLPC_P60; pfam00877 1150475002695 Transcriptional regulator; Region: Rrf2; cl17282 1150475002696 Rrf2 family protein; Region: rrf2_super; TIGR00738 1150475002697 Conserved TM helix; Region: TM_helix; pfam05552 1150475002698 Conserved TM helix; Region: TM_helix; pfam05552 1150475002699 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1150475002700 SpoVR like protein; Region: SpoVR; pfam04293 1150475002701 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1150475002702 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1150475002703 dimer interface [polypeptide binding]; other site 1150475002704 active site 1150475002705 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475002706 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475002707 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1150475002708 NlpC/P60 family; Region: NLPC_P60; pfam00877 1150475002709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475002710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475002711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475002712 dimerization interface [polypeptide binding]; other site 1150475002713 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1150475002714 dimer interface [polypeptide binding]; other site 1150475002715 Citrate synthase; Region: Citrate_synt; pfam00285 1150475002716 active site 1150475002717 citrylCoA binding site [chemical binding]; other site 1150475002718 oxalacetate/citrate binding site [chemical binding]; other site 1150475002719 coenzyme A binding site [chemical binding]; other site 1150475002720 catalytic triad [active] 1150475002721 short chain dehydrogenase; Provisional; Region: PRK06701 1150475002722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475002723 NAD(P) binding site [chemical binding]; other site 1150475002724 active site 1150475002725 amino acid transporter; Region: 2A0306; TIGR00909 1150475002726 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1150475002727 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1150475002728 Na2 binding site [ion binding]; other site 1150475002729 putative substrate binding site 1 [chemical binding]; other site 1150475002730 Na binding site 1 [ion binding]; other site 1150475002731 putative substrate binding site 2 [chemical binding]; other site 1150475002732 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1150475002733 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1150475002734 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1150475002735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475002736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475002737 DNA binding residues [nucleotide binding] 1150475002738 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1150475002739 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1150475002740 putative acyl-acceptor binding pocket; other site 1150475002741 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1150475002742 Domain of unknown function DUF21; Region: DUF21; pfam01595 1150475002743 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1150475002744 Transporter associated domain; Region: CorC_HlyC; smart01091 1150475002745 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1150475002746 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1150475002747 DNA binding residues [nucleotide binding] 1150475002748 putative dimer interface [polypeptide binding]; other site 1150475002749 aspartate aminotransferase; Provisional; Region: PRK06836 1150475002750 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475002751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475002752 homodimer interface [polypeptide binding]; other site 1150475002753 catalytic residue [active] 1150475002754 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1150475002755 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1150475002756 dimer interface [polypeptide binding]; other site 1150475002757 active site 1150475002758 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1150475002759 Domain of unknown function DUF21; Region: DUF21; pfam01595 1150475002760 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1150475002761 Transporter associated domain; Region: CorC_HlyC; smart01091 1150475002762 camphor resistance protein CrcB; Provisional; Region: PRK14213 1150475002763 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1150475002764 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1150475002765 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1150475002766 active site 1150475002767 catalytic site [active] 1150475002768 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1150475002769 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1150475002770 NAD-dependent deacetylase; Provisional; Region: PRK00481 1150475002771 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1150475002772 NAD+ binding site [chemical binding]; other site 1150475002773 substrate binding site [chemical binding]; other site 1150475002774 Zn binding site [ion binding]; other site 1150475002775 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1150475002776 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1150475002777 NodB motif; other site 1150475002778 active site 1150475002779 catalytic site [active] 1150475002780 Zn binding site [ion binding]; other site 1150475002781 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1150475002782 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1150475002783 homodimer interface [polypeptide binding]; other site 1150475002784 substrate-cofactor binding pocket; other site 1150475002785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475002786 catalytic residue [active] 1150475002787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475002788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475002789 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1150475002790 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1150475002791 Ligand Binding Site [chemical binding]; other site 1150475002792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1150475002793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475002794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475002795 Walker A/P-loop; other site 1150475002796 ATP binding site [chemical binding]; other site 1150475002797 Q-loop/lid; other site 1150475002798 ABC transporter signature motif; other site 1150475002799 Walker B; other site 1150475002800 D-loop; other site 1150475002801 H-loop/switch region; other site 1150475002802 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1150475002803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475002804 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1150475002805 Walker A/P-loop; other site 1150475002806 ATP binding site [chemical binding]; other site 1150475002807 Q-loop/lid; other site 1150475002808 ABC transporter signature motif; other site 1150475002809 Walker B; other site 1150475002810 D-loop; other site 1150475002811 H-loop/switch region; other site 1150475002812 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1150475002813 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1150475002814 NAD binding site [chemical binding]; other site 1150475002815 substrate binding site [chemical binding]; other site 1150475002816 putative active site [active] 1150475002817 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1150475002818 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1150475002819 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1150475002820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1150475002821 hypothetical protein; Provisional; Region: PRK13676 1150475002822 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1150475002823 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1150475002824 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1150475002825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475002826 active site 1150475002827 motif I; other site 1150475002828 motif II; other site 1150475002829 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1150475002830 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1150475002831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475002832 FeS/SAM binding site; other site 1150475002833 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1150475002834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1150475002835 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1150475002836 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1150475002837 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1150475002838 TrkA-C domain; Region: TrkA_C; pfam02080 1150475002839 enoyl-CoA hydratase; Provisional; Region: PRK07659 1150475002840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1150475002841 substrate binding site [chemical binding]; other site 1150475002842 oxyanion hole (OAH) forming residues; other site 1150475002843 trimer interface [polypeptide binding]; other site 1150475002844 YhzD-like protein; Region: YhzD; pfam14120 1150475002845 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1150475002846 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1150475002847 Walker A/P-loop; other site 1150475002848 ATP binding site [chemical binding]; other site 1150475002849 Q-loop/lid; other site 1150475002850 ABC transporter signature motif; other site 1150475002851 Walker B; other site 1150475002852 D-loop; other site 1150475002853 H-loop/switch region; other site 1150475002854 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1150475002855 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1150475002856 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1150475002857 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1150475002858 active site 1150475002859 metal binding site [ion binding]; metal-binding site 1150475002860 DNA binding site [nucleotide binding] 1150475002861 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1150475002862 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1150475002863 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1150475002864 generic binding surface II; other site 1150475002865 generic binding surface I; other site 1150475002866 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1150475002867 Zn2+ binding site [ion binding]; other site 1150475002868 Mg2+ binding site [ion binding]; other site 1150475002869 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1150475002870 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1150475002871 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1150475002872 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1150475002873 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1150475002874 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1150475002875 transcriptional regulator Hpr; Provisional; Region: PRK13777 1150475002876 MarR family; Region: MarR; pfam01047 1150475002877 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1150475002878 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1150475002879 homodimer interface [polypeptide binding]; other site 1150475002880 substrate-cofactor binding pocket; other site 1150475002881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475002882 catalytic residue [active] 1150475002883 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1150475002884 HIT family signature motif; other site 1150475002885 catalytic residue [active] 1150475002886 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1150475002887 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1150475002888 Walker A/P-loop; other site 1150475002889 ATP binding site [chemical binding]; other site 1150475002890 Q-loop/lid; other site 1150475002891 ABC transporter signature motif; other site 1150475002892 Walker B; other site 1150475002893 D-loop; other site 1150475002894 H-loop/switch region; other site 1150475002895 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1150475002896 EcsC protein family; Region: EcsC; pfam12787 1150475002897 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1150475002898 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1150475002899 metal binding site [ion binding]; metal-binding site 1150475002900 dimer interface [polypeptide binding]; other site 1150475002901 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1150475002902 Transglycosylase; Region: Transgly; pfam00912 1150475002903 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1150475002904 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1150475002905 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1150475002906 substrate binding site [chemical binding]; other site 1150475002907 active site 1150475002908 ferrochelatase; Provisional; Region: PRK12435 1150475002909 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1150475002910 C-terminal domain interface [polypeptide binding]; other site 1150475002911 active site 1150475002912 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1150475002913 active site 1150475002914 N-terminal domain interface [polypeptide binding]; other site 1150475002915 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1150475002916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1150475002917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475002918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475002919 Predicted membrane protein [Function unknown]; Region: COG1511 1150475002920 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1150475002921 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1150475002922 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1150475002923 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1150475002924 dimer interface [polypeptide binding]; other site 1150475002925 active site 1150475002926 CoA binding pocket [chemical binding]; other site 1150475002927 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1150475002928 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1150475002929 putative oligomer interface [polypeptide binding]; other site 1150475002930 putative active site [active] 1150475002931 metal binding site [ion binding]; metal-binding site 1150475002932 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1150475002933 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1150475002934 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1150475002935 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1150475002936 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1150475002937 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1150475002938 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1150475002939 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1150475002940 NAD(P) binding site [chemical binding]; other site 1150475002941 putative active site [active] 1150475002942 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1150475002943 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1150475002944 acyl-activating enzyme (AAE) consensus motif; other site 1150475002945 putative AMP binding site [chemical binding]; other site 1150475002946 putative active site [active] 1150475002947 putative CoA binding site [chemical binding]; other site 1150475002948 Peptidase family M48; Region: Peptidase_M48; pfam01435 1150475002949 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1150475002950 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1150475002951 active site 1150475002952 catalytic residues [active] 1150475002953 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1150475002954 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1150475002955 siderophore binding site; other site 1150475002956 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1150475002957 catalytic core [active] 1150475002958 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1150475002959 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1150475002960 dimer interface [polypeptide binding]; other site 1150475002961 active site 1150475002962 acyl-CoA synthetase; Validated; Region: PRK07638 1150475002963 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1150475002964 acyl-activating enzyme (AAE) consensus motif; other site 1150475002965 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1150475002966 acyl-activating enzyme (AAE) consensus motif; other site 1150475002967 AMP binding site [chemical binding]; other site 1150475002968 active site 1150475002969 CoA binding site [chemical binding]; other site 1150475002970 BioY family; Region: BioY; pfam02632 1150475002971 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1150475002972 heme-binding site [chemical binding]; other site 1150475002973 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1150475002974 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475002975 dimer interface [polypeptide binding]; other site 1150475002976 putative CheW interface [polypeptide binding]; other site 1150475002977 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1150475002978 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1150475002979 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1150475002980 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1150475002981 [2Fe-2S] cluster binding site [ion binding]; other site 1150475002982 short chain dehydrogenase; Provisional; Region: PRK06701 1150475002983 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1150475002984 NAD binding site [chemical binding]; other site 1150475002985 metal binding site [ion binding]; metal-binding site 1150475002986 active site 1150475002987 A short protein domain of unknown function; Region: IDEAL; smart00914 1150475002988 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1150475002989 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1150475002990 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1150475002991 MepB protein; Region: MepB; pfam08877 1150475002992 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1150475002993 putative binding site; other site 1150475002994 putative dimer interface [polypeptide binding]; other site 1150475002995 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1150475002996 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1150475002997 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1150475002998 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1150475002999 Na binding site [ion binding]; other site 1150475003000 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1150475003001 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1150475003002 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1150475003003 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1150475003004 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1150475003005 Catalytic site [active] 1150475003006 hypothetical protein; Provisional; Region: PRK08244 1150475003007 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1150475003008 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475003009 MarR family; Region: MarR; pfam01047 1150475003010 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1150475003011 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1150475003012 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1150475003013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475003014 putative substrate translocation pore; other site 1150475003015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475003016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475003017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475003018 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1150475003019 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1150475003020 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1150475003021 dinuclear metal binding motif [ion binding]; other site 1150475003022 Predicted membrane protein [Function unknown]; Region: COG2323 1150475003023 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1150475003024 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1150475003025 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1150475003026 Part of AAA domain; Region: AAA_19; pfam13245 1150475003027 Family description; Region: UvrD_C_2; pfam13538 1150475003028 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1150475003029 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1150475003030 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1150475003031 active site 1150475003032 metal binding site [ion binding]; metal-binding site 1150475003033 DNA binding site [nucleotide binding] 1150475003034 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1150475003035 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1150475003036 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1150475003037 Walker A/P-loop; other site 1150475003038 ATP binding site [chemical binding]; other site 1150475003039 Q-loop/lid; other site 1150475003040 ABC transporter signature motif; other site 1150475003041 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1150475003042 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1150475003043 ABC transporter signature motif; other site 1150475003044 Walker B; other site 1150475003045 D-loop; other site 1150475003046 H-loop/switch region; other site 1150475003047 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1150475003048 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1150475003049 Spore germination protein GerPC; Region: GerPC; pfam10737 1150475003050 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1150475003051 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1150475003052 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1150475003053 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1150475003054 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1150475003055 hypothetical protein; Provisional; Region: PRK13673 1150475003056 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1150475003057 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1150475003058 active site 1150475003059 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1150475003060 dimer interface [polypeptide binding]; other site 1150475003061 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1150475003062 Ligand Binding Site [chemical binding]; other site 1150475003063 Molecular Tunnel; other site 1150475003064 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1150475003065 substrate binding pocket [chemical binding]; other site 1150475003066 substrate-Mg2+ binding site; other site 1150475003067 aspartate-rich region 1; other site 1150475003068 aspartate-rich region 2; other site 1150475003069 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1150475003070 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1150475003071 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1150475003072 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1150475003073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1150475003074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1150475003075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1150475003076 DinB superfamily; Region: DinB_2; pfam12867 1150475003077 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1150475003078 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1150475003079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1150475003080 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1150475003081 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1150475003082 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1150475003083 FAD binding site [chemical binding]; other site 1150475003084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1150475003085 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1150475003086 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1150475003087 S1 domain; Region: S1_2; pfam13509 1150475003088 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1150475003089 RNA binding site [nucleotide binding]; other site 1150475003090 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1150475003091 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1150475003092 ligand binding site [chemical binding]; other site 1150475003093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475003094 dimerization interface [polypeptide binding]; other site 1150475003095 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1150475003096 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475003097 dimer interface [polypeptide binding]; other site 1150475003098 putative CheW interface [polypeptide binding]; other site 1150475003099 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1150475003100 Cytochrome P450; Region: p450; cl12078 1150475003101 EDD domain protein, DegV family; Region: DegV; TIGR00762 1150475003102 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1150475003103 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1150475003104 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475003105 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475003106 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1150475003107 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1150475003108 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1150475003109 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1150475003110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475003111 motif II; other site 1150475003112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475003113 esterase; Provisional; Region: PRK10566 1150475003114 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1150475003115 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1150475003116 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1150475003117 active site 1150475003118 metal binding site [ion binding]; metal-binding site 1150475003119 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1150475003120 FAD binding domain; Region: FAD_binding_4; pfam01565 1150475003121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475003122 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475003123 putative substrate translocation pore; other site 1150475003124 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1150475003125 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1150475003126 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1150475003127 heterotetramer interface [polypeptide binding]; other site 1150475003128 active site pocket [active] 1150475003129 cleavage site 1150475003130 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1150475003131 nucleotide binding site [chemical binding]; other site 1150475003132 N-acetyl-L-glutamate binding site [chemical binding]; other site 1150475003133 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1150475003134 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475003135 inhibitor-cofactor binding pocket; inhibition site 1150475003136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475003137 catalytic residue [active] 1150475003138 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1150475003139 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1150475003140 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1150475003141 catalytic site [active] 1150475003142 subunit interface [polypeptide binding]; other site 1150475003143 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1150475003144 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1150475003145 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1150475003146 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1150475003147 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1150475003148 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1150475003149 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1150475003150 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1150475003151 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1150475003152 YjzC-like protein; Region: YjzC; pfam14168 1150475003153 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1150475003154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475003155 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1150475003156 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1150475003157 putative ligand binding site [chemical binding]; other site 1150475003158 ComZ; Region: ComZ; pfam10815 1150475003159 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1150475003160 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1150475003161 dimer interface [polypeptide binding]; other site 1150475003162 active site 1150475003163 CoA binding pocket [chemical binding]; other site 1150475003164 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1150475003165 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1150475003166 dimer interface [polypeptide binding]; other site 1150475003167 active site 1150475003168 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1150475003169 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1150475003170 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1150475003171 Walker A/P-loop; other site 1150475003172 ATP binding site [chemical binding]; other site 1150475003173 Q-loop/lid; other site 1150475003174 ABC transporter signature motif; other site 1150475003175 Walker B; other site 1150475003176 D-loop; other site 1150475003177 H-loop/switch region; other site 1150475003178 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1150475003179 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1150475003180 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1150475003181 Walker A/P-loop; other site 1150475003182 ATP binding site [chemical binding]; other site 1150475003183 Q-loop/lid; other site 1150475003184 ABC transporter signature motif; other site 1150475003185 Walker B; other site 1150475003186 D-loop; other site 1150475003187 H-loop/switch region; other site 1150475003188 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1150475003189 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1150475003190 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1150475003191 peptide binding site [polypeptide binding]; other site 1150475003192 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1150475003193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475003194 dimer interface [polypeptide binding]; other site 1150475003195 conserved gate region; other site 1150475003196 putative PBP binding loops; other site 1150475003197 ABC-ATPase subunit interface; other site 1150475003198 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1150475003199 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1150475003200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475003201 dimer interface [polypeptide binding]; other site 1150475003202 conserved gate region; other site 1150475003203 putative PBP binding loops; other site 1150475003204 ABC-ATPase subunit interface; other site 1150475003205 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1150475003206 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1150475003207 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1150475003208 active site 1150475003209 HIGH motif; other site 1150475003210 dimer interface [polypeptide binding]; other site 1150475003211 KMSKS motif; other site 1150475003212 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1150475003213 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1150475003214 peptide binding site [polypeptide binding]; other site 1150475003215 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1150475003216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475003217 dimer interface [polypeptide binding]; other site 1150475003218 conserved gate region; other site 1150475003219 putative PBP binding loops; other site 1150475003220 ABC-ATPase subunit interface; other site 1150475003221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1150475003222 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1150475003223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475003224 dimer interface [polypeptide binding]; other site 1150475003225 conserved gate region; other site 1150475003226 putative PBP binding loops; other site 1150475003227 ABC-ATPase subunit interface; other site 1150475003228 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1150475003229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1150475003230 Walker A/P-loop; other site 1150475003231 ATP binding site [chemical binding]; other site 1150475003232 Q-loop/lid; other site 1150475003233 ABC transporter signature motif; other site 1150475003234 Walker B; other site 1150475003235 D-loop; other site 1150475003236 H-loop/switch region; other site 1150475003237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1150475003238 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1150475003239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1150475003240 Walker A/P-loop; other site 1150475003241 ATP binding site [chemical binding]; other site 1150475003242 Q-loop/lid; other site 1150475003243 ABC transporter signature motif; other site 1150475003244 Walker B; other site 1150475003245 D-loop; other site 1150475003246 H-loop/switch region; other site 1150475003247 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1150475003248 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1150475003249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1150475003250 Coenzyme A binding pocket [chemical binding]; other site 1150475003251 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1150475003252 ArsC family; Region: ArsC; pfam03960 1150475003253 putative catalytic residues [active] 1150475003254 thiol/disulfide switch; other site 1150475003255 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1150475003256 adaptor protein; Provisional; Region: PRK02315 1150475003257 Competence protein CoiA-like family; Region: CoiA; cl11541 1150475003258 oligoendopeptidase F; Region: pepF; TIGR00181 1150475003259 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1150475003260 active site 1150475003261 Zn binding site [ion binding]; other site 1150475003262 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1150475003263 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1150475003264 catalytic residues [active] 1150475003265 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1150475003266 apolar tunnel; other site 1150475003267 heme binding site [chemical binding]; other site 1150475003268 dimerization interface [polypeptide binding]; other site 1150475003269 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1150475003270 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1150475003271 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1150475003272 catalytic residue [active] 1150475003273 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1150475003274 putative active site [active] 1150475003275 putative metal binding residues [ion binding]; other site 1150475003276 signature motif; other site 1150475003277 putative triphosphate binding site [ion binding]; other site 1150475003278 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1150475003279 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1150475003280 synthetase active site [active] 1150475003281 NTP binding site [chemical binding]; other site 1150475003282 metal binding site [ion binding]; metal-binding site 1150475003283 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1150475003284 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1150475003285 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1150475003286 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1150475003287 active site 1150475003288 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1150475003289 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1150475003290 active site 1150475003291 metal binding site [ion binding]; metal-binding site 1150475003292 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1150475003293 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1150475003294 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1150475003295 TrkA-N domain; Region: TrkA_N; pfam02254 1150475003296 TrkA-C domain; Region: TrkA_C; pfam02080 1150475003297 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1150475003298 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1150475003299 thiamine phosphate binding site [chemical binding]; other site 1150475003300 active site 1150475003301 pyrophosphate binding site [ion binding]; other site 1150475003302 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1150475003303 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1150475003304 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1150475003305 thiS-thiF/thiG interaction site; other site 1150475003306 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1150475003307 ThiS interaction site; other site 1150475003308 putative active site [active] 1150475003309 tetramer interface [polypeptide binding]; other site 1150475003310 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1150475003311 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1150475003312 ATP binding site [chemical binding]; other site 1150475003313 substrate interface [chemical binding]; other site 1150475003314 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1150475003315 dimer interface [polypeptide binding]; other site 1150475003316 substrate binding site [chemical binding]; other site 1150475003317 ATP binding site [chemical binding]; other site 1150475003318 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1150475003319 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1150475003320 NAD binding site [chemical binding]; other site 1150475003321 homotetramer interface [polypeptide binding]; other site 1150475003322 homodimer interface [polypeptide binding]; other site 1150475003323 substrate binding site [chemical binding]; other site 1150475003324 active site 1150475003325 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1150475003326 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1150475003327 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1150475003328 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1150475003329 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1150475003330 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1150475003331 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1150475003332 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1150475003333 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1150475003334 Part of AAA domain; Region: AAA_19; pfam13245 1150475003335 Family description; Region: UvrD_C_2; pfam13538 1150475003336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1150475003337 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1150475003338 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1150475003339 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1150475003340 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1150475003341 Walker A/P-loop; other site 1150475003342 ATP binding site [chemical binding]; other site 1150475003343 Q-loop/lid; other site 1150475003344 ABC transporter signature motif; other site 1150475003345 Walker B; other site 1150475003346 D-loop; other site 1150475003347 H-loop/switch region; other site 1150475003348 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1150475003349 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1150475003350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1150475003351 Coenzyme A binding pocket [chemical binding]; other site 1150475003352 hypothetical protein; Provisional; Region: PRK13679 1150475003353 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1150475003354 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1150475003355 Putative esterase; Region: Esterase; pfam00756 1150475003356 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1150475003357 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1150475003358 homodimer interface [polypeptide binding]; other site 1150475003359 substrate-cofactor binding pocket; other site 1150475003360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475003361 catalytic residue [active] 1150475003362 cystathionine beta-lyase; Provisional; Region: PRK08064 1150475003363 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1150475003364 homodimer interface [polypeptide binding]; other site 1150475003365 substrate-cofactor binding pocket; other site 1150475003366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475003367 catalytic residue [active] 1150475003368 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1150475003369 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1150475003370 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin 1150475003371 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin 1150475003372 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10376821; Product type h : extrachromosomal origin 1150475003373 chlorophyllide a oxygenase; Region: PLN02281 1150475003374 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1150475003375 LXG domain of WXG superfamily; Region: LXG; pfam04740 1150475003376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475003377 Coenzyme A binding pocket [chemical binding]; other site 1150475003378 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1150475003379 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1150475003380 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1150475003381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475003382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475003383 putative substrate translocation pore; other site 1150475003384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475003385 MarR family; Region: MarR; pfam01047 1150475003386 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1150475003387 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1150475003388 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1150475003389 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1150475003390 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1150475003391 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1150475003392 NAD binding site [chemical binding]; other site 1150475003393 homodimer interface [polypeptide binding]; other site 1150475003394 active site 1150475003395 substrate binding site [chemical binding]; other site 1150475003396 galactokinase; Provisional; Region: PRK05322 1150475003397 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1150475003398 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1150475003399 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1150475003400 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1150475003401 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1150475003402 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1150475003403 active site 1150475003404 P-loop; other site 1150475003405 phosphorylation site [posttranslational modification] 1150475003406 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1150475003407 methionine cluster; other site 1150475003408 active site 1150475003409 phosphorylation site [posttranslational modification] 1150475003410 metal binding site [ion binding]; metal-binding site 1150475003411 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1150475003412 beta-galactosidase; Region: BGL; TIGR03356 1150475003413 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1150475003414 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1150475003415 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1150475003416 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1150475003417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475003418 motif II; other site 1150475003419 Kelch motif; Region: Kelch_6; pfam13964 1150475003420 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1150475003421 Kelch motif; Region: Kelch_1; pfam01344 1150475003422 Kelch motif; Region: Kelch_1; pfam01344 1150475003423 MgtC family; Region: MgtC; pfam02308 1150475003424 Putative motility protein; Region: YjfB_motility; pfam14070 1150475003425 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1150475003426 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1150475003427 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1150475003428 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1150475003429 catalytic loop [active] 1150475003430 iron binding site [ion binding]; other site 1150475003431 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 1150475003432 4Fe-4S binding domain; Region: Fer4; pfam00037 1150475003433 4Fe-4S binding domain; Region: Fer4; pfam00037 1150475003434 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1150475003435 [4Fe-4S] binding site [ion binding]; other site 1150475003436 molybdopterin cofactor binding site; other site 1150475003437 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1150475003438 molybdopterin cofactor binding site; other site 1150475003439 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1150475003440 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1150475003441 Cytochrome P450; Region: p450; cl12078 1150475003442 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1150475003443 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1150475003444 active site 1150475003445 TDP-binding site; other site 1150475003446 acceptor substrate-binding pocket; other site 1150475003447 homodimer interface [polypeptide binding]; other site 1150475003448 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1150475003449 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1150475003450 active site 1150475003451 TIGR00245 family protein; Region: TIGR00245 1150475003452 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1150475003453 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1150475003454 Walker A/P-loop; other site 1150475003455 ATP binding site [chemical binding]; other site 1150475003456 Q-loop/lid; other site 1150475003457 ABC transporter signature motif; other site 1150475003458 Walker B; other site 1150475003459 D-loop; other site 1150475003460 H-loop/switch region; other site 1150475003461 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1150475003462 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1150475003463 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1150475003464 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1150475003465 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475003466 Glucuronate isomerase; Region: UxaC; pfam02614 1150475003467 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1150475003468 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1150475003469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475003470 putative substrate translocation pore; other site 1150475003471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475003472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475003473 DNA binding site [nucleotide binding] 1150475003474 domain linker motif; other site 1150475003475 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1150475003476 dimerization interface [polypeptide binding]; other site 1150475003477 ligand binding site [chemical binding]; other site 1150475003478 altronate oxidoreductase; Provisional; Region: PRK03643 1150475003479 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1150475003480 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1150475003481 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1150475003482 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1150475003483 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1150475003484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475003485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475003486 active site 1150475003487 phosphorylation site [posttranslational modification] 1150475003488 intermolecular recognition site; other site 1150475003489 dimerization interface [polypeptide binding]; other site 1150475003490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475003491 DNA binding site [nucleotide binding] 1150475003492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475003493 HAMP domain; Region: HAMP; pfam00672 1150475003494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475003495 dimer interface [polypeptide binding]; other site 1150475003496 phosphorylation site [posttranslational modification] 1150475003497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475003498 ATP binding site [chemical binding]; other site 1150475003499 Mg2+ binding site [ion binding]; other site 1150475003500 G-X-G motif; other site 1150475003501 Integrase core domain; Region: rve; pfam00665 1150475003502 Integrase core domain; Region: rve_2; pfam13333 1150475003503 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1150475003504 DinB family; Region: DinB; cl17821 1150475003505 DinB superfamily; Region: DinB_2; pfam12867 1150475003506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475003507 binding surface 1150475003508 TPR motif; other site 1150475003509 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475003510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1150475003511 binding surface 1150475003512 TPR motif; other site 1150475003513 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1150475003514 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1150475003515 amidase catalytic site [active] 1150475003516 Zn binding residues [ion binding]; other site 1150475003517 substrate binding site [chemical binding]; other site 1150475003518 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475003519 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475003520 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1150475003521 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1150475003522 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1150475003523 pentamer interface [polypeptide binding]; other site 1150475003524 dodecaamer interface [polypeptide binding]; other site 1150475003525 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1150475003526 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1150475003527 dimanganese center [ion binding]; other site 1150475003528 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1150475003529 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1150475003530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475003531 non-specific DNA binding site [nucleotide binding]; other site 1150475003532 salt bridge; other site 1150475003533 sequence-specific DNA binding site [nucleotide binding]; other site 1150475003534 hypothetical protein; Provisional; Region: PRK06921 1150475003535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475003536 Walker A motif; other site 1150475003537 ATP binding site [chemical binding]; other site 1150475003538 Walker B motif; other site 1150475003539 positive control sigma-like factor; Validated; Region: PRK06930 1150475003540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475003541 DNA binding residues [nucleotide binding] 1150475003542 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1150475003543 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1150475003544 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1150475003545 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1150475003546 Phage capsid family; Region: Phage_capsid; pfam05065 1150475003547 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1150475003548 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1150475003549 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1150475003550 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1150475003551 Phage XkdN-like protein; Region: XkdN; pfam08890 1150475003552 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1150475003553 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1150475003554 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1150475003555 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1150475003556 catalytic residue [active] 1150475003557 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1150475003558 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475003559 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1150475003560 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1150475003561 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1150475003562 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1150475003563 XkdW protein; Region: XkdW; pfam09636 1150475003564 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1150475003565 Haemolysin XhlA; Region: XhlA; pfam10779 1150475003566 Phage lysis protein, holin; Region: Phage_holin; pfam04688 1150475003567 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1150475003568 amidase catalytic site [active] 1150475003569 Zn binding residues [ion binding]; other site 1150475003570 substrate binding site [chemical binding]; other site 1150475003571 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475003572 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1150475003573 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1150475003574 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1150475003575 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1150475003576 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1150475003577 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1150475003578 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1150475003579 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1150475003580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475003581 Zn binding site [ion binding]; other site 1150475003582 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1150475003583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475003584 Zn binding site [ion binding]; other site 1150475003585 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1150475003586 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1150475003587 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1150475003588 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1150475003589 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1150475003590 Ligand binding site; other site 1150475003591 Putative Catalytic site; other site 1150475003592 DXD motif; other site 1150475003593 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1150475003594 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1150475003595 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1150475003596 protein binding site [polypeptide binding]; other site 1150475003597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475003598 putative substrate translocation pore; other site 1150475003599 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1150475003600 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1150475003601 SxDxEG motif; other site 1150475003602 active site 1150475003603 metal binding site [ion binding]; metal-binding site 1150475003604 homopentamer interface [polypeptide binding]; other site 1150475003605 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1150475003606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475003607 dimer interface [polypeptide binding]; other site 1150475003608 conserved gate region; other site 1150475003609 putative PBP binding loops; other site 1150475003610 ABC-ATPase subunit interface; other site 1150475003611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1150475003612 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1150475003613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475003614 dimer interface [polypeptide binding]; other site 1150475003615 conserved gate region; other site 1150475003616 putative PBP binding loops; other site 1150475003617 ABC-ATPase subunit interface; other site 1150475003618 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1150475003619 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1150475003620 Walker A/P-loop; other site 1150475003621 ATP binding site [chemical binding]; other site 1150475003622 Q-loop/lid; other site 1150475003623 ABC transporter signature motif; other site 1150475003624 Walker B; other site 1150475003625 D-loop; other site 1150475003626 H-loop/switch region; other site 1150475003627 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1150475003628 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1150475003629 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1150475003630 peptide binding site [polypeptide binding]; other site 1150475003631 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1150475003632 dimer interface [polypeptide binding]; other site 1150475003633 catalytic triad [active] 1150475003634 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1150475003635 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1150475003636 active site 1150475003637 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1150475003638 NlpC/P60 family; Region: NLPC_P60; pfam00877 1150475003639 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1150475003640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1150475003641 Walker A/P-loop; other site 1150475003642 ATP binding site [chemical binding]; other site 1150475003643 Q-loop/lid; other site 1150475003644 ABC transporter signature motif; other site 1150475003645 Walker B; other site 1150475003646 D-loop; other site 1150475003647 H-loop/switch region; other site 1150475003648 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1150475003649 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1150475003650 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1150475003651 Amidinotransferase; Region: Amidinotransf; pfam02274 1150475003652 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1150475003653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1150475003654 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1150475003655 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1150475003656 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1150475003657 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1150475003658 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1150475003659 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1150475003660 putative active site [active] 1150475003661 putative substrate binding site [chemical binding]; other site 1150475003662 putative cosubstrate binding site; other site 1150475003663 catalytic site [active] 1150475003664 gamma-glutamyl kinase; Provisional; Region: PRK05429 1150475003665 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1150475003666 nucleotide binding site [chemical binding]; other site 1150475003667 homotetrameric interface [polypeptide binding]; other site 1150475003668 putative phosphate binding site [ion binding]; other site 1150475003669 putative allosteric binding site; other site 1150475003670 PUA domain; Region: PUA; pfam01472 1150475003671 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1150475003672 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1150475003673 putative catalytic cysteine [active] 1150475003674 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1150475003675 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1150475003676 MarR family; Region: MarR; pfam01047 1150475003677 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1150475003678 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1150475003679 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1150475003680 putative metal binding site; other site 1150475003681 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1150475003682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475003683 binding surface 1150475003684 TPR motif; other site 1150475003685 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1150475003686 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1150475003687 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1150475003688 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1150475003689 ligand binding site [chemical binding]; other site 1150475003690 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1150475003691 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1150475003692 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1150475003693 THF binding site; other site 1150475003694 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1150475003695 substrate binding site [chemical binding]; other site 1150475003696 THF binding site; other site 1150475003697 zinc-binding site [ion binding]; other site 1150475003698 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1150475003699 active site 1150475003700 catalytic residues [active] 1150475003701 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1150475003702 Cobalt transport protein; Region: CbiQ; pfam02361 1150475003703 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1150475003704 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1150475003705 Walker A/P-loop; other site 1150475003706 ATP binding site [chemical binding]; other site 1150475003707 Q-loop/lid; other site 1150475003708 ABC transporter signature motif; other site 1150475003709 Walker B; other site 1150475003710 D-loop; other site 1150475003711 H-loop/switch region; other site 1150475003712 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1150475003713 Walker A/P-loop; other site 1150475003714 ATP binding site [chemical binding]; other site 1150475003715 Q-loop/lid; other site 1150475003716 ABC transporter signature motif; other site 1150475003717 Walker B; other site 1150475003718 D-loop; other site 1150475003719 H-loop/switch region; other site 1150475003720 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1150475003721 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1150475003722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475003723 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475003724 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1150475003725 active site 1150475003726 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1150475003727 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1150475003728 MgtE intracellular N domain; Region: MgtE_N; smart00924 1150475003729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1150475003730 Divalent cation transporter; Region: MgtE; pfam01769 1150475003731 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1150475003732 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1150475003733 DNA binding residues [nucleotide binding] 1150475003734 putative dimer interface [polypeptide binding]; other site 1150475003735 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475003736 MarR family; Region: MarR; pfam01047 1150475003737 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1150475003738 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1150475003739 active site 1150475003740 DNA binding site [nucleotide binding] 1150475003741 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1150475003742 nucleotide binding site [chemical binding]; other site 1150475003743 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1150475003744 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1150475003745 putative DNA binding site [nucleotide binding]; other site 1150475003746 putative homodimer interface [polypeptide binding]; other site 1150475003747 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1150475003748 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1150475003749 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1150475003750 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1150475003751 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475003752 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1150475003753 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1150475003754 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1150475003755 heat shock protein HtpX; Provisional; Region: PRK05457 1150475003756 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1150475003757 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1150475003758 Predicted membrane protein [Function unknown]; Region: COG2323 1150475003759 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1150475003760 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1150475003761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475003762 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1150475003763 putative active site [active] 1150475003764 heme pocket [chemical binding]; other site 1150475003765 PAS domain; Region: PAS; smart00091 1150475003766 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1150475003767 PAS domain; Region: PAS; smart00091 1150475003768 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1150475003769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475003770 dimer interface [polypeptide binding]; other site 1150475003771 phosphorylation site [posttranslational modification] 1150475003772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475003773 ATP binding site [chemical binding]; other site 1150475003774 Mg2+ binding site [ion binding]; other site 1150475003775 G-X-G motif; other site 1150475003776 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1150475003777 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1150475003778 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1150475003779 DNA binding site [nucleotide binding] 1150475003780 active site 1150475003781 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1150475003782 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1150475003783 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1150475003784 Phosphotransferase enzyme family; Region: APH; pfam01636 1150475003785 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1150475003786 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1150475003787 putative active site [active] 1150475003788 catalytic triad [active] 1150475003789 putative dimer interface [polypeptide binding]; other site 1150475003790 transaminase; Reviewed; Region: PRK08068 1150475003791 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475003792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475003793 homodimer interface [polypeptide binding]; other site 1150475003794 catalytic residue [active] 1150475003795 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1150475003796 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1150475003797 dimer interface [polypeptide binding]; other site 1150475003798 active site 1150475003799 catalytic residue [active] 1150475003800 metal binding site [ion binding]; metal-binding site 1150475003801 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1150475003802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475003803 motif II; other site 1150475003804 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1150475003805 intersubunit interface [polypeptide binding]; other site 1150475003806 active site 1150475003807 Zn2+ binding site [ion binding]; other site 1150475003808 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1150475003809 Cupin domain; Region: Cupin_2; pfam07883 1150475003810 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1150475003811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475003812 dimer interface [polypeptide binding]; other site 1150475003813 phosphorylation site [posttranslational modification] 1150475003814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475003815 ATP binding site [chemical binding]; other site 1150475003816 Mg2+ binding site [ion binding]; other site 1150475003817 G-X-G motif; other site 1150475003818 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475003819 MarR family; Region: MarR; pfam01047 1150475003820 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1150475003821 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1150475003822 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1150475003823 ligand binding site [chemical binding]; other site 1150475003824 flagellar motor protein MotA; Validated; Region: PRK08124 1150475003825 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1150475003826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475003827 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1150475003828 Walker A motif; other site 1150475003829 ATP binding site [chemical binding]; other site 1150475003830 Walker B motif; other site 1150475003831 arginine finger; other site 1150475003832 UvrB/uvrC motif; Region: UVR; pfam02151 1150475003833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475003834 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1150475003835 Walker A motif; other site 1150475003836 ATP binding site [chemical binding]; other site 1150475003837 Walker B motif; other site 1150475003838 arginine finger; other site 1150475003839 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1150475003840 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1150475003841 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1150475003842 Ligand Binding Site [chemical binding]; other site 1150475003843 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1150475003844 active site 1150475003845 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1150475003846 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1150475003847 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1150475003848 Predicted transcriptional regulators [Transcription]; Region: COG1733 1150475003849 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1150475003850 short chain dehydrogenase; Provisional; Region: PRK06500 1150475003851 classical (c) SDRs; Region: SDR_c; cd05233 1150475003852 NAD(P) binding site [chemical binding]; other site 1150475003853 active site 1150475003854 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1150475003855 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1150475003856 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1150475003857 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475003858 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475003859 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475003860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475003861 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1150475003862 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1150475003863 active site 1150475003864 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1150475003865 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1150475003866 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1150475003867 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1150475003868 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1150475003869 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1150475003870 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1150475003871 catalytic residues [active] 1150475003872 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1150475003873 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1150475003874 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1150475003875 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1150475003876 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1150475003877 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1150475003878 active site 1150475003879 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475003880 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475003881 DNA binding site [nucleotide binding] 1150475003882 domain linker motif; other site 1150475003883 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1150475003884 putative dimerization interface [polypeptide binding]; other site 1150475003885 putative ligand binding site [chemical binding]; other site 1150475003886 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1150475003887 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1150475003888 PRD domain; Region: PRD; pfam00874 1150475003889 PRD domain; Region: PRD; pfam00874 1150475003890 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1150475003891 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1150475003892 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1150475003893 active site turn [active] 1150475003894 phosphorylation site [posttranslational modification] 1150475003895 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1150475003896 HPr interaction site; other site 1150475003897 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1150475003898 active site 1150475003899 phosphorylation site [posttranslational modification] 1150475003900 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1150475003901 dimerization domain swap beta strand [polypeptide binding]; other site 1150475003902 regulatory protein interface [polypeptide binding]; other site 1150475003903 active site 1150475003904 regulatory phosphorylation site [posttranslational modification]; other site 1150475003905 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1150475003906 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1150475003907 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1150475003908 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1150475003909 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1150475003910 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1150475003911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475003912 FeS/SAM binding site; other site 1150475003913 Cache domain; Region: Cache_1; pfam02743 1150475003914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475003915 dimerization interface [polypeptide binding]; other site 1150475003916 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475003917 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1150475003918 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475003919 dimer interface [polypeptide binding]; other site 1150475003920 putative CheW interface [polypeptide binding]; other site 1150475003921 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1150475003922 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1150475003923 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1150475003924 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1150475003925 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1150475003926 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1150475003927 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1150475003928 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1150475003929 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1150475003930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475003931 putative active site [active] 1150475003932 heme pocket [chemical binding]; other site 1150475003933 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1150475003934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475003935 putative active site [active] 1150475003936 heme pocket [chemical binding]; other site 1150475003937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475003938 putative active site [active] 1150475003939 heme pocket [chemical binding]; other site 1150475003940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475003941 dimer interface [polypeptide binding]; other site 1150475003942 phosphorylation site [posttranslational modification] 1150475003943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475003944 ATP binding site [chemical binding]; other site 1150475003945 Mg2+ binding site [ion binding]; other site 1150475003946 G-X-G motif; other site 1150475003947 aminotransferase A; Validated; Region: PRK07683 1150475003948 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475003949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475003950 homodimer interface [polypeptide binding]; other site 1150475003951 catalytic residue [active] 1150475003952 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1150475003953 putative CheA interaction surface; other site 1150475003954 Response regulator receiver domain; Region: Response_reg; pfam00072 1150475003955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475003956 active site 1150475003957 phosphorylation site [posttranslational modification] 1150475003958 intermolecular recognition site; other site 1150475003959 dimerization interface [polypeptide binding]; other site 1150475003960 YkyB-like protein; Region: YkyB; pfam14177 1150475003961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475003962 H+ Antiporter protein; Region: 2A0121; TIGR00900 1150475003963 putative substrate translocation pore; other site 1150475003964 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475003965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1150475003966 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1150475003967 phosphodiesterase YaeI; Provisional; Region: PRK11340 1150475003968 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1150475003969 putative active site [active] 1150475003970 putative metal binding site [ion binding]; other site 1150475003971 short chain dehydrogenase; Provisional; Region: PRK07677 1150475003972 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1150475003973 NAD(P) binding site [chemical binding]; other site 1150475003974 substrate binding site [chemical binding]; other site 1150475003975 homotetramer interface [polypeptide binding]; other site 1150475003976 active site 1150475003977 homodimer interface [polypeptide binding]; other site 1150475003978 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1150475003979 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1150475003980 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1150475003981 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1150475003982 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1150475003983 FOG: CBS domain [General function prediction only]; Region: COG0517 1150475003984 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1150475003985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475003986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475003987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475003988 dimerization interface [polypeptide binding]; other site 1150475003989 flavodoxin; Provisional; Region: PRK06703 1150475003990 BNR repeat-like domain; Region: BNR_2; pfam13088 1150475003991 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1150475003992 flavodoxin, short chain; Region: flav_short; TIGR01753 1150475003993 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1150475003994 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1150475003995 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1150475003996 active site 1150475003997 trimer interface [polypeptide binding]; other site 1150475003998 substrate binding site [chemical binding]; other site 1150475003999 CoA binding site [chemical binding]; other site 1150475004000 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1150475004001 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1150475004002 metal binding site [ion binding]; metal-binding site 1150475004003 hypothetical protein; Provisional; Region: PRK03094 1150475004004 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1150475004005 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1150475004006 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1150475004007 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1150475004008 catalytic residues [active] 1150475004009 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1150475004010 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1150475004011 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1150475004012 GTP binding site; other site 1150475004013 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1150475004014 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1150475004015 ATP binding site [chemical binding]; other site 1150475004016 substrate interface [chemical binding]; other site 1150475004017 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1150475004018 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1150475004019 dimer interface [polypeptide binding]; other site 1150475004020 putative functional site; other site 1150475004021 putative MPT binding site; other site 1150475004022 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1150475004023 Walker A motif; other site 1150475004024 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1150475004025 MoaE homodimer interface [polypeptide binding]; other site 1150475004026 MoaD interaction [polypeptide binding]; other site 1150475004027 active site residues [active] 1150475004028 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1150475004029 MoaE interaction surface [polypeptide binding]; other site 1150475004030 MoeB interaction surface [polypeptide binding]; other site 1150475004031 thiocarboxylated glycine; other site 1150475004032 Yip1 domain; Region: Yip1; pfam04893 1150475004033 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1150475004034 HlyD family secretion protein; Region: HlyD_3; pfam13437 1150475004035 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1150475004036 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1150475004037 Walker A/P-loop; other site 1150475004038 ATP binding site [chemical binding]; other site 1150475004039 Q-loop/lid; other site 1150475004040 ABC transporter signature motif; other site 1150475004041 Walker B; other site 1150475004042 D-loop; other site 1150475004043 H-loop/switch region; other site 1150475004044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1150475004045 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1150475004046 FtsX-like permease family; Region: FtsX; pfam02687 1150475004047 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1150475004048 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1150475004049 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1150475004050 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1150475004051 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1150475004052 putative substrate binding site [chemical binding]; other site 1150475004053 putative ATP binding site [chemical binding]; other site 1150475004054 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1150475004055 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1150475004056 active site 1150475004057 phosphorylation site [posttranslational modification] 1150475004058 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1150475004059 active site 1150475004060 P-loop; other site 1150475004061 phosphorylation site [posttranslational modification] 1150475004062 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1150475004063 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1150475004064 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1150475004065 Catalytic site [active] 1150475004066 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1150475004067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475004068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475004069 ABC transporter; Region: ABC_tran_2; pfam12848 1150475004070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475004071 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1150475004072 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1150475004073 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1150475004074 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1150475004075 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1150475004076 rod-share determining protein MreBH; Provisional; Region: PRK13929 1150475004077 MreB and similar proteins; Region: MreB_like; cd10225 1150475004078 nucleotide binding site [chemical binding]; other site 1150475004079 Mg binding site [ion binding]; other site 1150475004080 putative protofilament interaction site [polypeptide binding]; other site 1150475004081 RodZ interaction site [polypeptide binding]; other site 1150475004082 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1150475004083 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1150475004084 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1150475004085 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1150475004086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475004087 putative active site [active] 1150475004088 heme pocket [chemical binding]; other site 1150475004089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475004090 dimer interface [polypeptide binding]; other site 1150475004091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475004092 ATP binding site [chemical binding]; other site 1150475004093 Mg2+ binding site [ion binding]; other site 1150475004094 G-X-G motif; other site 1150475004095 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1150475004096 putative active site pocket [active] 1150475004097 dimerization interface [polypeptide binding]; other site 1150475004098 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1150475004099 putative active site pocket [active] 1150475004100 dimerization interface [polypeptide binding]; other site 1150475004101 putative catalytic residue [active] 1150475004102 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1150475004103 TrkA-N domain; Region: TrkA_N; pfam02254 1150475004104 TrkA-C domain; Region: TrkA_C; pfam02080 1150475004105 adenine deaminase; Region: ade; TIGR01178 1150475004106 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1150475004107 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1150475004108 active site 1150475004109 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1150475004110 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1150475004111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1150475004112 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1150475004113 hypothetical protein; Provisional; Region: PRK13667 1150475004114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475004115 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1150475004116 active site 1150475004117 motif I; other site 1150475004118 motif II; other site 1150475004119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475004120 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1150475004121 active site 1150475004122 catalytic residues [active] 1150475004123 metal binding site [ion binding]; metal-binding site 1150475004124 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1150475004125 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1150475004126 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1150475004127 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1150475004128 FMN binding site [chemical binding]; other site 1150475004129 substrate binding site [chemical binding]; other site 1150475004130 putative catalytic residue [active] 1150475004131 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004132 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004133 active site 1150475004134 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004135 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004136 putative NADP binding site [chemical binding]; other site 1150475004137 active site 1150475004138 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475004139 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004140 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004141 active site 1150475004142 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475004143 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004144 putative NADP binding site [chemical binding]; other site 1150475004145 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004146 active site 1150475004147 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004148 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004149 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1150475004150 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004151 active site 1150475004152 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475004153 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004154 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004155 putative NADP binding site [chemical binding]; other site 1150475004156 active site 1150475004157 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004158 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004159 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004160 active site 1150475004161 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475004162 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004163 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004164 putative NADP binding site [chemical binding]; other site 1150475004165 active site 1150475004166 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475004167 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004168 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004169 active site 1150475004170 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475004171 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004172 putative NADP binding site [chemical binding]; other site 1150475004173 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004174 active site 1150475004175 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004176 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004177 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1150475004178 active site 1150475004179 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004180 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004181 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004182 putative NADP binding site [chemical binding]; other site 1150475004183 active site 1150475004184 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475004185 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004186 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004187 active site 1150475004188 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004189 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004190 putative NADP binding site [chemical binding]; other site 1150475004191 active site 1150475004192 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004193 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004194 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004195 active site 1150475004196 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004197 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475004198 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004199 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004200 putative NADP binding site [chemical binding]; other site 1150475004201 active site 1150475004202 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004203 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004204 active site 1150475004205 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004206 putative NADP binding site [chemical binding]; other site 1150475004207 KR domain; Region: KR; pfam08659 1150475004208 active site 1150475004209 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475004210 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004211 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004212 active site 1150475004213 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004214 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004215 putative NADP binding site [chemical binding]; other site 1150475004216 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475004217 active site 1150475004218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475004219 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475004220 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475004221 active site 1150475004222 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475004223 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475004224 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475004225 putative NADP binding site [chemical binding]; other site 1150475004226 KR domain; Region: KR; pfam08659 1150475004227 active site 1150475004228 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1150475004229 Beta-lactamase; Region: Beta-lactamase; pfam00144 1150475004230 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1150475004231 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1150475004232 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1150475004233 TPP-binding site [chemical binding]; other site 1150475004234 tetramer interface [polypeptide binding]; other site 1150475004235 heterodimer interface [polypeptide binding]; other site 1150475004236 phosphorylation loop region [posttranslational modification] 1150475004237 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1150475004238 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1150475004239 alpha subunit interface [polypeptide binding]; other site 1150475004240 TPP binding site [chemical binding]; other site 1150475004241 heterodimer interface [polypeptide binding]; other site 1150475004242 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1150475004243 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1150475004244 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1150475004245 E3 interaction surface; other site 1150475004246 lipoyl attachment site [posttranslational modification]; other site 1150475004247 e3 binding domain; Region: E3_binding; pfam02817 1150475004248 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1150475004249 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1150475004250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1150475004251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475004252 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1150475004253 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1150475004254 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1150475004255 NodB motif; other site 1150475004256 active site 1150475004257 catalytic site [active] 1150475004258 metal binding site [ion binding]; metal-binding site 1150475004259 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1150475004260 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1150475004261 homodimer interface [polypeptide binding]; other site 1150475004262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475004263 catalytic residue [active] 1150475004264 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1150475004265 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1150475004266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1150475004267 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1150475004268 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1150475004269 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1150475004270 active site 1150475004271 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1150475004272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475004273 Coenzyme A binding pocket [chemical binding]; other site 1150475004274 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1150475004275 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1150475004276 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1150475004277 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1150475004278 active site 1150475004279 Zn binding site [ion binding]; other site 1150475004280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475004281 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1150475004282 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475004283 DNA binding residues [nucleotide binding] 1150475004284 Putative zinc-finger; Region: zf-HC2; pfam13490 1150475004285 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1150475004286 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1150475004287 G1 box; other site 1150475004288 putative GEF interaction site [polypeptide binding]; other site 1150475004289 GTP/Mg2+ binding site [chemical binding]; other site 1150475004290 Switch I region; other site 1150475004291 G2 box; other site 1150475004292 G3 box; other site 1150475004293 Switch II region; other site 1150475004294 G4 box; other site 1150475004295 G5 box; other site 1150475004296 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1150475004297 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1150475004298 YlaH-like protein; Region: YlaH; pfam14036 1150475004299 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1150475004300 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1150475004301 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1150475004302 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1150475004303 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1150475004304 putative active site [active] 1150475004305 PhoH-like protein; Region: PhoH; pfam02562 1150475004306 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1150475004307 glutaminase A; Region: Gln_ase; TIGR03814 1150475004308 hypothetical protein; Provisional; Region: PRK13666 1150475004309 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1150475004310 pyruvate carboxylase; Reviewed; Region: PRK12999 1150475004311 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1150475004312 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1150475004313 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1150475004314 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1150475004315 active site 1150475004316 catalytic residues [active] 1150475004317 metal binding site [ion binding]; metal-binding site 1150475004318 homodimer binding site [polypeptide binding]; other site 1150475004319 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1150475004320 carboxyltransferase (CT) interaction site; other site 1150475004321 biotinylation site [posttranslational modification]; other site 1150475004322 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1150475004323 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1150475004324 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1150475004325 UbiA prenyltransferase family; Region: UbiA; pfam01040 1150475004326 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1150475004327 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1150475004328 Cytochrome c; Region: Cytochrom_C; pfam00034 1150475004329 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1150475004330 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1150475004331 D-pathway; other site 1150475004332 Putative ubiquinol binding site [chemical binding]; other site 1150475004333 Low-spin heme (heme b) binding site [chemical binding]; other site 1150475004334 Putative water exit pathway; other site 1150475004335 Binuclear center (heme o3/CuB) [ion binding]; other site 1150475004336 K-pathway; other site 1150475004337 Putative proton exit pathway; other site 1150475004338 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1150475004339 Subunit I/III interface [polypeptide binding]; other site 1150475004340 Subunit III/IV interface [polypeptide binding]; other site 1150475004341 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1150475004342 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1150475004343 YugN-like family; Region: YugN; pfam08868 1150475004344 FOG: CBS domain [General function prediction only]; Region: COG0517 1150475004345 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1150475004346 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1150475004347 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1150475004348 Putative coat protein; Region: YlbD_coat; pfam14071 1150475004349 YlbE-like protein; Region: YlbE; pfam14003 1150475004350 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1150475004351 hypothetical protein; Provisional; Region: PRK02886 1150475004352 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1150475004353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475004354 S-adenosylmethionine binding site [chemical binding]; other site 1150475004355 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1150475004356 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1150475004357 active site 1150475004358 (T/H)XGH motif; other site 1150475004359 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1150475004360 Nucleoside recognition; Region: Gate; pfam07670 1150475004361 Nucleoside recognition; Region: Gate; pfam07670 1150475004362 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1150475004363 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1150475004364 active site 1150475004365 nucleophile elbow; other site 1150475004366 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1150475004367 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1150475004368 protein binding site [polypeptide binding]; other site 1150475004369 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1150475004370 hypothetical protein; Provisional; Region: PRK13670 1150475004371 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1150475004372 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1150475004373 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1150475004374 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1150475004375 hypothetical protein; Provisional; Region: PRK13688 1150475004376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475004377 Coenzyme A binding pocket [chemical binding]; other site 1150475004378 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1150475004379 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1150475004380 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1150475004381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1150475004382 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1150475004383 mraZ protein; Region: TIGR00242 1150475004384 MraZ protein; Region: MraZ; pfam02381 1150475004385 MraZ protein; Region: MraZ; pfam02381 1150475004386 MraW methylase family; Region: Methyltransf_5; pfam01795 1150475004387 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1150475004388 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1150475004389 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1150475004390 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1150475004391 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1150475004392 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1150475004393 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1150475004394 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1150475004395 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1150475004396 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1150475004397 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1150475004398 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1150475004399 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1150475004400 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1150475004401 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1150475004402 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1150475004403 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1150475004404 Mg++ binding site [ion binding]; other site 1150475004405 putative catalytic motif [active] 1150475004406 putative substrate binding site [chemical binding]; other site 1150475004407 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1150475004408 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1150475004409 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1150475004410 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1150475004411 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1150475004412 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1150475004413 active site 1150475004414 homodimer interface [polypeptide binding]; other site 1150475004415 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1150475004416 FAD binding domain; Region: FAD_binding_4; pfam01565 1150475004417 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1150475004418 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1150475004419 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1150475004420 Cell division protein FtsQ; Region: FtsQ; pfam03799 1150475004421 cell division protein FtsA; Region: ftsA; TIGR01174 1150475004422 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1150475004423 nucleotide binding site [chemical binding]; other site 1150475004424 Cell division protein FtsA; Region: FtsA; pfam14450 1150475004425 cell division protein FtsZ; Validated; Region: PRK09330 1150475004426 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1150475004427 nucleotide binding site [chemical binding]; other site 1150475004428 SulA interaction site; other site 1150475004429 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1150475004430 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1150475004431 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1150475004432 active site 1150475004433 catalytic triad [active] 1150475004434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1150475004435 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1150475004436 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1150475004437 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1150475004438 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1150475004439 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1150475004440 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1150475004441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475004442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475004443 DNA binding residues [nucleotide binding] 1150475004444 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1150475004445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475004446 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1150475004447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475004448 DNA binding residues [nucleotide binding] 1150475004449 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1150475004450 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1150475004451 Walker A/P-loop; other site 1150475004452 ATP binding site [chemical binding]; other site 1150475004453 Q-loop/lid; other site 1150475004454 ABC transporter signature motif; other site 1150475004455 Walker B; other site 1150475004456 D-loop; other site 1150475004457 H-loop/switch region; other site 1150475004458 acetylornithine deacetylase; Validated; Region: PRK08596 1150475004459 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1150475004460 metal binding site [ion binding]; metal-binding site 1150475004461 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1150475004462 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1150475004463 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1150475004464 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1150475004465 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1150475004466 catalytic residue [active] 1150475004467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1150475004468 YGGT family; Region: YGGT; pfam02325 1150475004469 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1150475004470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1150475004471 RNA binding surface [nucleotide binding]; other site 1150475004472 DivIVA protein; Region: DivIVA; pfam05103 1150475004473 DivIVA domain; Region: DivI1A_domain; TIGR03544 1150475004474 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1150475004475 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1150475004476 HIGH motif; other site 1150475004477 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1150475004478 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1150475004479 active site 1150475004480 KMSKS motif; other site 1150475004481 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1150475004482 tRNA binding surface [nucleotide binding]; other site 1150475004483 anticodon binding site; other site 1150475004484 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1150475004485 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1150475004486 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1150475004487 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1150475004488 RNA binding surface [nucleotide binding]; other site 1150475004489 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1150475004490 active site 1150475004491 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1150475004492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475004493 active site 1150475004494 uracil-xanthine permease; Region: ncs2; TIGR00801 1150475004495 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1150475004496 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1150475004497 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1150475004498 dihydroorotase; Validated; Region: pyrC; PRK09357 1150475004499 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1150475004500 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1150475004501 active site 1150475004502 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1150475004503 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1150475004504 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1150475004505 catalytic site [active] 1150475004506 subunit interface [polypeptide binding]; other site 1150475004507 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1150475004508 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1150475004509 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1150475004510 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1150475004511 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1150475004512 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1150475004513 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1150475004514 IMP binding site; other site 1150475004515 dimer interface [polypeptide binding]; other site 1150475004516 interdomain contacts; other site 1150475004517 partial ornithine binding site; other site 1150475004518 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1150475004519 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1150475004520 FAD binding pocket [chemical binding]; other site 1150475004521 FAD binding motif [chemical binding]; other site 1150475004522 phosphate binding motif [ion binding]; other site 1150475004523 beta-alpha-beta structure motif; other site 1150475004524 NAD binding pocket [chemical binding]; other site 1150475004525 Iron coordination center [ion binding]; other site 1150475004526 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1150475004527 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1150475004528 heterodimer interface [polypeptide binding]; other site 1150475004529 active site 1150475004530 FMN binding site [chemical binding]; other site 1150475004531 homodimer interface [polypeptide binding]; other site 1150475004532 substrate binding site [chemical binding]; other site 1150475004533 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1150475004534 active site 1150475004535 dimer interface [polypeptide binding]; other site 1150475004536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475004537 active site 1150475004538 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1150475004539 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1150475004540 Active Sites [active] 1150475004541 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1150475004542 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1150475004543 ATP-sulfurylase; Region: ATPS; cd00517 1150475004544 active site 1150475004545 HXXH motif; other site 1150475004546 flexible loop; other site 1150475004547 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1150475004548 AAA domain; Region: AAA_18; pfam13238 1150475004549 ligand-binding site [chemical binding]; other site 1150475004550 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1150475004551 diphthine synthase; Region: dph5; TIGR00522 1150475004552 active site 1150475004553 SAM binding site [chemical binding]; other site 1150475004554 homodimer interface [polypeptide binding]; other site 1150475004555 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1150475004556 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1150475004557 putative active site [active] 1150475004558 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1150475004559 putative active site [active] 1150475004560 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1150475004561 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1150475004562 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1150475004563 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1150475004564 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1150475004565 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1150475004566 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1150475004567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475004568 motif II; other site 1150475004569 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1150475004570 hypothetical protein; Provisional; Region: PRK11820 1150475004571 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1150475004572 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1150475004573 hypothetical protein; Provisional; Region: PRK04323 1150475004574 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1150475004575 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1150475004576 catalytic site [active] 1150475004577 G-X2-G-X-G-K; other site 1150475004578 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1150475004579 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1150475004580 Flavoprotein; Region: Flavoprotein; pfam02441 1150475004581 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1150475004582 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1150475004583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475004584 ATP binding site [chemical binding]; other site 1150475004585 putative Mg++ binding site [ion binding]; other site 1150475004586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475004587 nucleotide binding region [chemical binding]; other site 1150475004588 ATP-binding site [chemical binding]; other site 1150475004589 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1150475004590 active site 1150475004591 catalytic residues [active] 1150475004592 metal binding site [ion binding]; metal-binding site 1150475004593 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1150475004594 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1150475004595 putative active site [active] 1150475004596 substrate binding site [chemical binding]; other site 1150475004597 putative cosubstrate binding site; other site 1150475004598 catalytic site [active] 1150475004599 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1150475004600 substrate binding site [chemical binding]; other site 1150475004601 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1150475004602 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1150475004603 putative RNA binding site [nucleotide binding]; other site 1150475004604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475004605 S-adenosylmethionine binding site [chemical binding]; other site 1150475004606 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1150475004607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475004608 FeS/SAM binding site; other site 1150475004609 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1150475004610 Protein phosphatase 2C; Region: PP2C; pfam00481 1150475004611 active site 1150475004612 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1150475004613 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1150475004614 active site 1150475004615 ATP binding site [chemical binding]; other site 1150475004616 substrate binding site [chemical binding]; other site 1150475004617 activation loop (A-loop); other site 1150475004618 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1150475004619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1150475004620 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1150475004621 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1150475004622 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1150475004623 GTPase RsgA; Reviewed; Region: PRK00098 1150475004624 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1150475004625 RNA binding site [nucleotide binding]; other site 1150475004626 homodimer interface [polypeptide binding]; other site 1150475004627 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1150475004628 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1150475004629 GTP/Mg2+ binding site [chemical binding]; other site 1150475004630 G4 box; other site 1150475004631 G5 box; other site 1150475004632 G1 box; other site 1150475004633 Switch I region; other site 1150475004634 G2 box; other site 1150475004635 G3 box; other site 1150475004636 Switch II region; other site 1150475004637 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1150475004638 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1150475004639 substrate binding site [chemical binding]; other site 1150475004640 hexamer interface [polypeptide binding]; other site 1150475004641 metal binding site [ion binding]; metal-binding site 1150475004642 Thiamine pyrophosphokinase; Region: TPK; cd07995 1150475004643 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1150475004644 active site 1150475004645 dimerization interface [polypeptide binding]; other site 1150475004646 thiamine binding site [chemical binding]; other site 1150475004647 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1150475004648 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1150475004649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1150475004650 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1150475004651 DAK2 domain; Region: Dak2; pfam02734 1150475004652 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1150475004653 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1150475004654 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1150475004655 putative L-serine binding site [chemical binding]; other site 1150475004656 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1150475004657 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1150475004658 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1150475004659 Y-family of DNA polymerases; Region: PolY; cl12025 1150475004660 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1150475004661 generic binding surface II; other site 1150475004662 ssDNA binding site; other site 1150475004663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475004664 ATP binding site [chemical binding]; other site 1150475004665 putative Mg++ binding site [ion binding]; other site 1150475004666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475004667 nucleotide binding region [chemical binding]; other site 1150475004668 ATP-binding site [chemical binding]; other site 1150475004669 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1150475004670 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1150475004671 putative phosphate acyltransferase; Provisional; Region: PRK05331 1150475004672 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1150475004673 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1150475004674 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1150475004675 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1150475004676 NAD(P) binding site [chemical binding]; other site 1150475004677 homotetramer interface [polypeptide binding]; other site 1150475004678 homodimer interface [polypeptide binding]; other site 1150475004679 active site 1150475004680 acyl carrier protein; Provisional; Region: acpP; PRK00982 1150475004681 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1150475004682 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1150475004683 dimerization interface [polypeptide binding]; other site 1150475004684 active site 1150475004685 metal binding site [ion binding]; metal-binding site 1150475004686 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1150475004687 dsRNA binding site [nucleotide binding]; other site 1150475004688 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1150475004689 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1150475004690 Walker A/P-loop; other site 1150475004691 ATP binding site [chemical binding]; other site 1150475004692 Q-loop/lid; other site 1150475004693 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1150475004694 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1150475004695 ABC transporter signature motif; other site 1150475004696 Walker B; other site 1150475004697 D-loop; other site 1150475004698 H-loop/switch region; other site 1150475004699 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1150475004700 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1150475004701 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1150475004702 GTP binding site [chemical binding]; other site 1150475004703 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1150475004704 putative DNA-binding protein; Validated; Region: PRK00118 1150475004705 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1150475004706 signal recognition particle protein; Provisional; Region: PRK10867 1150475004707 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1150475004708 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1150475004709 P loop; other site 1150475004710 GTP binding site [chemical binding]; other site 1150475004711 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1150475004712 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1150475004713 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1150475004714 KH domain; Region: KH_4; pfam13083 1150475004715 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1150475004716 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1150475004717 RimM N-terminal domain; Region: RimM; pfam01782 1150475004718 PRC-barrel domain; Region: PRC; pfam05239 1150475004719 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1150475004720 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1150475004721 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1150475004722 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1150475004723 GTP/Mg2+ binding site [chemical binding]; other site 1150475004724 G4 box; other site 1150475004725 G5 box; other site 1150475004726 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1150475004727 G1 box; other site 1150475004728 G1 box; other site 1150475004729 GTP/Mg2+ binding site [chemical binding]; other site 1150475004730 Switch I region; other site 1150475004731 G2 box; other site 1150475004732 G2 box; other site 1150475004733 G3 box; other site 1150475004734 G3 box; other site 1150475004735 Switch II region; other site 1150475004736 Switch II region; other site 1150475004737 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1150475004738 RNA/DNA hybrid binding site [nucleotide binding]; other site 1150475004739 active site 1150475004740 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1150475004741 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1150475004742 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1150475004743 CoA-ligase; Region: Ligase_CoA; pfam00549 1150475004744 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1150475004745 CoA binding domain; Region: CoA_binding; smart00881 1150475004746 CoA-ligase; Region: Ligase_CoA; pfam00549 1150475004747 DNA protecting protein DprA; Region: dprA; TIGR00732 1150475004748 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1150475004749 DNA topoisomerase I; Validated; Region: PRK05582 1150475004750 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1150475004751 active site 1150475004752 interdomain interaction site; other site 1150475004753 putative metal-binding site [ion binding]; other site 1150475004754 nucleotide binding site [chemical binding]; other site 1150475004755 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1150475004756 domain I; other site 1150475004757 DNA binding groove [nucleotide binding] 1150475004758 phosphate binding site [ion binding]; other site 1150475004759 domain II; other site 1150475004760 domain III; other site 1150475004761 nucleotide binding site [chemical binding]; other site 1150475004762 catalytic site [active] 1150475004763 domain IV; other site 1150475004764 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1150475004765 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1150475004766 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1150475004767 Glucose inhibited division protein A; Region: GIDA; pfam01134 1150475004768 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1150475004769 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1150475004770 active site 1150475004771 Int/Topo IB signature motif; other site 1150475004772 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1150475004773 active site 1150475004774 HslU subunit interaction site [polypeptide binding]; other site 1150475004775 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1150475004776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475004777 Walker A motif; other site 1150475004778 ATP binding site [chemical binding]; other site 1150475004779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1150475004780 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1150475004781 transcriptional repressor CodY; Validated; Region: PRK04158 1150475004782 CodY GAF-like domain; Region: CodY; pfam06018 1150475004783 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1150475004784 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1150475004785 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1150475004786 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1150475004787 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1150475004788 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1150475004789 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1150475004790 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1150475004791 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1150475004792 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1150475004793 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1150475004794 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1150475004795 MgtE intracellular N domain; Region: MgtE_N; smart00924 1150475004796 FliG C-terminal domain; Region: FliG_C; pfam01706 1150475004797 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1150475004798 Flagellar assembly protein FliH; Region: FliH; pfam02108 1150475004799 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1150475004800 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1150475004801 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1150475004802 Walker A motif/ATP binding site; other site 1150475004803 Walker B motif; other site 1150475004804 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1150475004805 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1150475004806 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1150475004807 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1150475004808 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1150475004809 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1150475004810 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1150475004811 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1150475004812 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1150475004813 Flagellar protein (FlbD); Region: FlbD; pfam06289 1150475004814 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1150475004815 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1150475004816 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1150475004817 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1150475004818 flagellar motor switch protein; Validated; Region: PRK08119 1150475004819 CheC-like family; Region: CheC; pfam04509 1150475004820 CheC-like family; Region: CheC; pfam04509 1150475004821 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1150475004822 Response regulator receiver domain; Region: Response_reg; pfam00072 1150475004823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475004824 active site 1150475004825 phosphorylation site [posttranslational modification] 1150475004826 intermolecular recognition site; other site 1150475004827 dimerization interface [polypeptide binding]; other site 1150475004828 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1150475004829 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1150475004830 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1150475004831 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1150475004832 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1150475004833 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1150475004834 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1150475004835 FHIPEP family; Region: FHIPEP; pfam00771 1150475004836 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1150475004837 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1150475004838 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1150475004839 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1150475004840 P-loop; other site 1150475004841 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1150475004842 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1150475004843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475004844 active site 1150475004845 phosphorylation site [posttranslational modification] 1150475004846 intermolecular recognition site; other site 1150475004847 dimerization interface [polypeptide binding]; other site 1150475004848 CheB methylesterase; Region: CheB_methylest; pfam01339 1150475004849 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1150475004850 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1150475004851 putative binding surface; other site 1150475004852 active site 1150475004853 P2 response regulator binding domain; Region: P2; pfam07194 1150475004854 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1150475004855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475004856 ATP binding site [chemical binding]; other site 1150475004857 Mg2+ binding site [ion binding]; other site 1150475004858 G-X-G motif; other site 1150475004859 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1150475004860 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1150475004861 putative CheA interaction surface; other site 1150475004862 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1150475004863 CheC-like family; Region: CheC; pfam04509 1150475004864 CheC-like family; Region: CheC; pfam04509 1150475004865 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1150475004866 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1150475004867 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475004868 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1150475004869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475004870 DNA binding residues [nucleotide binding] 1150475004871 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1150475004872 rRNA interaction site [nucleotide binding]; other site 1150475004873 S8 interaction site; other site 1150475004874 putative laminin-1 binding site; other site 1150475004875 elongation factor Ts; Provisional; Region: tsf; PRK09377 1150475004876 UBA/TS-N domain; Region: UBA; pfam00627 1150475004877 Elongation factor TS; Region: EF_TS; pfam00889 1150475004878 Elongation factor TS; Region: EF_TS; pfam00889 1150475004879 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1150475004880 putative nucleotide binding site [chemical binding]; other site 1150475004881 uridine monophosphate binding site [chemical binding]; other site 1150475004882 homohexameric interface [polypeptide binding]; other site 1150475004883 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1150475004884 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1150475004885 hinge region; other site 1150475004886 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1150475004887 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1150475004888 catalytic residue [active] 1150475004889 putative FPP diphosphate binding site; other site 1150475004890 putative FPP binding hydrophobic cleft; other site 1150475004891 dimer interface [polypeptide binding]; other site 1150475004892 putative IPP diphosphate binding site; other site 1150475004893 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1150475004894 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1150475004895 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1150475004896 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1150475004897 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1150475004898 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1150475004899 RIP metalloprotease RseP; Region: TIGR00054 1150475004900 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1150475004901 active site 1150475004902 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1150475004903 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1150475004904 protein binding site [polypeptide binding]; other site 1150475004905 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1150475004906 putative substrate binding region [chemical binding]; other site 1150475004907 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1150475004908 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1150475004909 dimer interface [polypeptide binding]; other site 1150475004910 motif 1; other site 1150475004911 active site 1150475004912 motif 2; other site 1150475004913 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1150475004914 putative deacylase active site [active] 1150475004915 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1150475004916 active site 1150475004917 motif 3; other site 1150475004918 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1150475004919 anticodon binding site; other site 1150475004920 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1150475004921 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1150475004922 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1150475004923 generic binding surface II; other site 1150475004924 generic binding surface I; other site 1150475004925 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1150475004926 active site 1150475004927 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1150475004928 active site 1150475004929 catalytic site [active] 1150475004930 substrate binding site [chemical binding]; other site 1150475004931 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1150475004932 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1150475004933 Sm and related proteins; Region: Sm_like; cl00259 1150475004934 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1150475004935 putative oligomer interface [polypeptide binding]; other site 1150475004936 putative RNA binding site [nucleotide binding]; other site 1150475004937 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1150475004938 NusA N-terminal domain; Region: NusA_N; pfam08529 1150475004939 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1150475004940 RNA binding site [nucleotide binding]; other site 1150475004941 homodimer interface [polypeptide binding]; other site 1150475004942 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1150475004943 G-X-X-G motif; other site 1150475004944 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1150475004945 G-X-X-G motif; other site 1150475004946 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1150475004947 putative RNA binding cleft [nucleotide binding]; other site 1150475004948 hypothetical protein; Provisional; Region: PRK07714 1150475004949 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1150475004950 translation initiation factor IF-2; Region: IF-2; TIGR00487 1150475004951 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1150475004952 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1150475004953 G1 box; other site 1150475004954 putative GEF interaction site [polypeptide binding]; other site 1150475004955 GTP/Mg2+ binding site [chemical binding]; other site 1150475004956 Switch I region; other site 1150475004957 G2 box; other site 1150475004958 G3 box; other site 1150475004959 Switch II region; other site 1150475004960 G4 box; other site 1150475004961 G5 box; other site 1150475004962 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1150475004963 Translation-initiation factor 2; Region: IF-2; pfam11987 1150475004964 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1150475004965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1150475004966 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1150475004967 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1150475004968 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1150475004969 RNA binding site [nucleotide binding]; other site 1150475004970 active site 1150475004971 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1150475004972 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1150475004973 active site 1150475004974 Riboflavin kinase; Region: Flavokinase; smart00904 1150475004975 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1150475004976 16S/18S rRNA binding site [nucleotide binding]; other site 1150475004977 S13e-L30e interaction site [polypeptide binding]; other site 1150475004978 25S rRNA binding site [nucleotide binding]; other site 1150475004979 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1150475004980 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1150475004981 RNase E interface [polypeptide binding]; other site 1150475004982 trimer interface [polypeptide binding]; other site 1150475004983 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1150475004984 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1150475004985 RNase E interface [polypeptide binding]; other site 1150475004986 trimer interface [polypeptide binding]; other site 1150475004987 active site 1150475004988 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1150475004989 putative nucleic acid binding region [nucleotide binding]; other site 1150475004990 G-X-X-G motif; other site 1150475004991 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1150475004992 RNA binding site [nucleotide binding]; other site 1150475004993 domain interface; other site 1150475004994 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1150475004995 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1150475004996 NodB motif; other site 1150475004997 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1150475004998 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1150475004999 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1150475005000 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1150475005001 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1150475005002 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1150475005003 NAD binding site [chemical binding]; other site 1150475005004 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1150475005005 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1150475005006 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1150475005007 aspartate kinase I; Reviewed; Region: PRK08210 1150475005008 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1150475005009 putative catalytic residues [active] 1150475005010 putative nucleotide binding site [chemical binding]; other site 1150475005011 putative aspartate binding site [chemical binding]; other site 1150475005012 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1150475005013 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1150475005014 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1150475005015 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1150475005016 dimer interface [polypeptide binding]; other site 1150475005017 active site 1150475005018 catalytic residue [active] 1150475005019 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1150475005020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1150475005021 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1150475005022 Clp protease; Region: CLP_protease; pfam00574 1150475005023 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1150475005024 active site 1150475005025 YlzJ-like protein; Region: YlzJ; pfam14035 1150475005026 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1150475005027 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1150475005028 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1150475005029 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1150475005030 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1150475005031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475005032 DNA-binding site [nucleotide binding]; DNA binding site 1150475005033 UTRA domain; Region: UTRA; pfam07702 1150475005034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475005035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475005036 putative substrate translocation pore; other site 1150475005037 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475005038 MarR family; Region: MarR_2; pfam12802 1150475005039 MMPL family; Region: MMPL; pfam03176 1150475005040 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1150475005041 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1150475005042 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1150475005043 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1150475005044 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1150475005045 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1150475005046 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1150475005047 classical (c) SDRs; Region: SDR_c; cd05233 1150475005048 NAD(P) binding site [chemical binding]; other site 1150475005049 active site 1150475005050 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1150475005051 ACT domain; Region: ACT; pfam01842 1150475005052 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1150475005053 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1150475005054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475005055 non-specific DNA binding site [nucleotide binding]; other site 1150475005056 salt bridge; other site 1150475005057 sequence-specific DNA binding site [nucleotide binding]; other site 1150475005058 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1150475005059 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1150475005060 competence damage-inducible protein A; Provisional; Region: PRK00549 1150475005061 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1150475005062 putative MPT binding site; other site 1150475005063 Competence-damaged protein; Region: CinA; pfam02464 1150475005064 recombinase A; Provisional; Region: recA; PRK09354 1150475005065 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1150475005066 hexamer interface [polypeptide binding]; other site 1150475005067 Walker A motif; other site 1150475005068 ATP binding site [chemical binding]; other site 1150475005069 Walker B motif; other site 1150475005070 Beta-lactamase; Region: Beta-lactamase; pfam00144 1150475005071 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1150475005072 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1150475005073 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1150475005074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1150475005075 Zn2+ binding site [ion binding]; other site 1150475005076 Mg2+ binding site [ion binding]; other site 1150475005077 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1150475005078 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1150475005079 putative active site [active] 1150475005080 metal binding site [ion binding]; metal-binding site 1150475005081 homodimer binding site [polypeptide binding]; other site 1150475005082 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1150475005083 Threonine dehydrogenase; Region: TDH; cd05281 1150475005084 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1150475005085 structural Zn binding site [ion binding]; other site 1150475005086 catalytic Zn binding site [ion binding]; other site 1150475005087 tetramer interface [polypeptide binding]; other site 1150475005088 NADP binding site [chemical binding]; other site 1150475005089 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1150475005090 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1150475005091 substrate-cofactor binding pocket; other site 1150475005092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475005093 catalytic residue [active] 1150475005094 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1150475005095 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1150475005096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475005097 FeS/SAM binding site; other site 1150475005098 TRAM domain; Region: TRAM; pfam01938 1150475005099 Predicted membrane protein [Function unknown]; Region: COG4550 1150475005100 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1150475005101 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1150475005102 MutS domain I; Region: MutS_I; pfam01624 1150475005103 MutS domain II; Region: MutS_II; pfam05188 1150475005104 MutS domain III; Region: MutS_III; pfam05192 1150475005105 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1150475005106 Walker A/P-loop; other site 1150475005107 ATP binding site [chemical binding]; other site 1150475005108 Q-loop/lid; other site 1150475005109 ABC transporter signature motif; other site 1150475005110 Walker B; other site 1150475005111 D-loop; other site 1150475005112 H-loop/switch region; other site 1150475005113 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1150475005114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475005115 ATP binding site [chemical binding]; other site 1150475005116 Mg2+ binding site [ion binding]; other site 1150475005117 G-X-G motif; other site 1150475005118 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1150475005119 ATP binding site [chemical binding]; other site 1150475005120 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1150475005121 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 1150475005122 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1150475005123 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1150475005124 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1150475005125 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1150475005126 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1150475005127 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1150475005128 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1150475005129 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1150475005130 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1150475005131 FMN binding site [chemical binding]; other site 1150475005132 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1150475005133 substrate binding site [chemical binding]; other site 1150475005134 putative catalytic residue [active] 1150475005135 acyl carrier protein; Validated; Region: PRK07117 1150475005136 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1150475005137 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1150475005138 dimer interface [polypeptide binding]; other site 1150475005139 active site 1150475005140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1150475005141 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1150475005142 substrate binding site [chemical binding]; other site 1150475005143 oxyanion hole (OAH) forming residues; other site 1150475005144 trimer interface [polypeptide binding]; other site 1150475005145 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1150475005146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1150475005147 substrate binding site [chemical binding]; other site 1150475005148 oxyanion hole (OAH) forming residues; other site 1150475005149 trimer interface [polypeptide binding]; other site 1150475005150 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1150475005151 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1150475005152 acyl-activating enzyme (AAE) consensus motif; other site 1150475005153 putative AMP binding site [chemical binding]; other site 1150475005154 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005155 Condensation domain; Region: Condensation; pfam00668 1150475005156 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005157 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005158 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1150475005159 acyl-activating enzyme (AAE) consensus motif; other site 1150475005160 AMP binding site [chemical binding]; other site 1150475005161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005162 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475005163 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005164 active site 1150475005165 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475005166 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005167 KR domain; Region: KR; pfam08659 1150475005168 putative NADP binding site [chemical binding]; other site 1150475005169 active site 1150475005170 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475005171 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005172 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475005173 active site 1150475005174 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005175 putative NADP binding site [chemical binding]; other site 1150475005176 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475005177 active site 1150475005178 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005179 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005180 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475005181 active site 1150475005182 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475005183 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475005184 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005185 active site 1150475005186 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475005187 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005188 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475005189 putative NADP binding site [chemical binding]; other site 1150475005190 active site 1150475005191 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475005192 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005193 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475005194 active site 1150475005195 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475005196 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475005197 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005198 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475005199 active site 1150475005200 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005201 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475005202 putative NADP binding site [chemical binding]; other site 1150475005203 active site 1150475005204 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005205 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005206 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475005207 active site 1150475005208 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475005209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005210 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005211 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475005212 active site 1150475005213 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475005214 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005215 putative NADP binding site [chemical binding]; other site 1150475005216 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475005217 active site 1150475005218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475005219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005220 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005221 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475005222 active site 1150475005223 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005224 putative NADP binding site [chemical binding]; other site 1150475005225 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475005226 active site 1150475005227 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005228 Condensation domain; Region: Condensation; pfam00668 1150475005229 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005230 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005231 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005232 acyl-activating enzyme (AAE) consensus motif; other site 1150475005233 AMP binding site [chemical binding]; other site 1150475005234 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005235 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475005236 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005237 active site 1150475005238 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475005239 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005240 putative NADP binding site [chemical binding]; other site 1150475005241 KR domain; Region: KR; pfam08659 1150475005242 active site 1150475005243 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475005244 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475005245 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005246 active site 1150475005247 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475005248 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005249 putative NADP binding site [chemical binding]; other site 1150475005250 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475005251 active site 1150475005252 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475005253 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475005254 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005255 active site 1150475005256 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475005257 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475005258 putative NADP binding site [chemical binding]; other site 1150475005259 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475005260 active site 1150475005261 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1150475005262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475005263 S-adenosylmethionine binding site [chemical binding]; other site 1150475005264 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475005265 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005266 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475005267 active site 1150475005268 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475005269 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1150475005270 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005271 active site 1150475005272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005273 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1150475005274 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1150475005275 Cytochrome P450; Region: p450; cl12078 1150475005276 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1150475005277 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1150475005278 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1150475005279 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1150475005280 active site 1150475005281 catalytic triad [active] 1150475005282 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1150475005283 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1150475005284 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1150475005285 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1150475005286 YmaF family; Region: YmaF; pfam12788 1150475005287 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1150475005288 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1150475005289 bacterial Hfq-like; Region: Hfq; cd01716 1150475005290 hexamer interface [polypeptide binding]; other site 1150475005291 Sm1 motif; other site 1150475005292 RNA binding site [nucleotide binding]; other site 1150475005293 Sm2 motif; other site 1150475005294 YmzC-like protein; Region: YmzC; pfam14157 1150475005295 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1150475005296 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1150475005297 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1150475005298 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1150475005299 active site 1150475005300 dimer interface [polypeptide binding]; other site 1150475005301 catalytic residues [active] 1150475005302 effector binding site; other site 1150475005303 R2 peptide binding site; other site 1150475005304 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1150475005305 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1150475005306 dimer interface [polypeptide binding]; other site 1150475005307 putative radical transfer pathway; other site 1150475005308 diiron center [ion binding]; other site 1150475005309 tyrosyl radical; other site 1150475005310 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1150475005311 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1150475005312 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1150475005313 active site 1150475005314 metal binding site [ion binding]; metal-binding site 1150475005315 Sporulation related domain; Region: SPOR; cl10051 1150475005316 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1150475005317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475005318 Walker A motif; other site 1150475005319 ATP binding site [chemical binding]; other site 1150475005320 Walker B motif; other site 1150475005321 arginine finger; other site 1150475005322 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1150475005323 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1150475005324 HflX GTPase family; Region: HflX; cd01878 1150475005325 G1 box; other site 1150475005326 GTP/Mg2+ binding site [chemical binding]; other site 1150475005327 Switch I region; other site 1150475005328 G2 box; other site 1150475005329 G3 box; other site 1150475005330 Switch II region; other site 1150475005331 G4 box; other site 1150475005332 G5 box; other site 1150475005333 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1150475005334 Aluminium resistance protein; Region: Alum_res; pfam06838 1150475005335 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1150475005336 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1150475005337 DNA binding residues [nucleotide binding] 1150475005338 glutamine synthetase, type I; Region: GlnA; TIGR00653 1150475005339 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1150475005340 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1150475005341 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1150475005342 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme 1150475005343 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1150475005344 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1150475005345 Major royal jelly protein; Region: MRJP; pfam03022 1150475005346 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1150475005347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475005348 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1150475005349 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1150475005350 inhibitor binding site; inhibition site 1150475005351 active site 1150475005352 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1150475005353 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1150475005354 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1150475005355 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1150475005356 nucleotide binding site [chemical binding]; other site 1150475005357 xylose isomerase; Provisional; Region: PRK05474 1150475005358 xylose isomerase; Region: xylose_isom_A; TIGR02630 1150475005359 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1150475005360 N- and C-terminal domain interface [polypeptide binding]; other site 1150475005361 D-xylulose kinase; Region: XylB; TIGR01312 1150475005362 active site 1150475005363 MgATP binding site [chemical binding]; other site 1150475005364 catalytic site [active] 1150475005365 metal binding site [ion binding]; metal-binding site 1150475005366 xylulose binding site [chemical binding]; other site 1150475005367 homodimer interface [polypeptide binding]; other site 1150475005368 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1150475005369 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1150475005370 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1150475005371 DinB family; Region: DinB; cl17821 1150475005372 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1150475005373 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1150475005374 NAD binding site [chemical binding]; other site 1150475005375 substrate binding site [chemical binding]; other site 1150475005376 catalytic Zn binding site [ion binding]; other site 1150475005377 tetramer interface [polypeptide binding]; other site 1150475005378 structural Zn binding site [ion binding]; other site 1150475005379 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1150475005380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475005381 Coenzyme A binding pocket [chemical binding]; other site 1150475005382 YoaP-like; Region: YoaP; pfam14268 1150475005383 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1150475005384 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1150475005385 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1150475005386 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1150475005387 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1150475005388 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1150475005389 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1150475005390 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1150475005391 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1150475005392 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1150475005393 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1150475005394 trimer interface [polypeptide binding]; other site 1150475005395 active site 1150475005396 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1150475005397 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1150475005398 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1150475005399 LexA repressor; Validated; Region: PRK00215 1150475005400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475005401 putative DNA binding site [nucleotide binding]; other site 1150475005402 putative Zn2+ binding site [ion binding]; other site 1150475005403 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1150475005404 Catalytic site [active] 1150475005405 cell division suppressor protein YneA; Provisional; Region: PRK14125 1150475005406 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475005407 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1150475005408 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1150475005409 catalytic residues [active] 1150475005410 catalytic nucleophile [active] 1150475005411 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1150475005412 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1150475005413 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1150475005414 TPP-binding site [chemical binding]; other site 1150475005415 dimer interface [polypeptide binding]; other site 1150475005416 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1150475005417 PYR/PP interface [polypeptide binding]; other site 1150475005418 dimer interface [polypeptide binding]; other site 1150475005419 TPP binding site [chemical binding]; other site 1150475005420 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1150475005421 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1150475005422 hypothetical protein; Provisional; Region: PRK01844 1150475005423 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1150475005424 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1150475005425 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1150475005426 Response regulator receiver domain; Region: Response_reg; pfam00072 1150475005427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475005428 active site 1150475005429 phosphorylation site [posttranslational modification] 1150475005430 intermolecular recognition site; other site 1150475005431 dimerization interface [polypeptide binding]; other site 1150475005432 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1150475005433 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1150475005434 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1150475005435 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1150475005436 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1150475005437 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1150475005438 aconitate hydratase; Validated; Region: PRK09277 1150475005439 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1150475005440 substrate binding site [chemical binding]; other site 1150475005441 ligand binding site [chemical binding]; other site 1150475005442 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1150475005443 substrate binding site [chemical binding]; other site 1150475005444 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1150475005445 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1150475005446 catalytic residues [active] 1150475005447 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1150475005448 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1150475005449 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1150475005450 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1150475005451 active site 1150475005452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1150475005453 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1150475005454 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1150475005455 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1150475005456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475005457 ATP binding site [chemical binding]; other site 1150475005458 Mg2+ binding site [ion binding]; other site 1150475005459 G-X-G motif; other site 1150475005460 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1150475005461 anchoring element; other site 1150475005462 dimer interface [polypeptide binding]; other site 1150475005463 ATP binding site [chemical binding]; other site 1150475005464 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1150475005465 active site 1150475005466 putative metal-binding site [ion binding]; other site 1150475005467 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1150475005468 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1150475005469 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1150475005470 CAP-like domain; other site 1150475005471 active site 1150475005472 primary dimer interface [polypeptide binding]; other site 1150475005473 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475005474 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475005475 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475005476 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1150475005477 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1150475005478 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1150475005479 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1150475005480 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1150475005481 substrate binding site [chemical binding]; other site 1150475005482 ATP binding site [chemical binding]; other site 1150475005483 putative oxidoreductase; Provisional; Region: PRK10083 1150475005484 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1150475005485 putative NAD(P) binding site [chemical binding]; other site 1150475005486 catalytic Zn binding site [ion binding]; other site 1150475005487 structural Zn binding site [ion binding]; other site 1150475005488 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1150475005489 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1150475005490 active site 1150475005491 intersubunit interface [polypeptide binding]; other site 1150475005492 catalytic residue [active] 1150475005493 mannonate dehydratase; Provisional; Region: PRK03906 1150475005494 mannonate dehydratase; Region: uxuA; TIGR00695 1150475005495 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1150475005496 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1150475005497 putative NAD(P) binding site [chemical binding]; other site 1150475005498 active site 1150475005499 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475005500 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475005501 DNA binding site [nucleotide binding] 1150475005502 domain linker motif; other site 1150475005503 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1150475005504 putative dimerization interface [polypeptide binding]; other site 1150475005505 putative ligand binding site [chemical binding]; other site 1150475005506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475005507 D-galactonate transporter; Region: 2A0114; TIGR00893 1150475005508 putative substrate translocation pore; other site 1150475005509 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1150475005510 YndJ-like protein; Region: YndJ; pfam14158 1150475005511 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 1150475005512 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1150475005513 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1150475005514 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1150475005515 Cellulose binding domain; Region: CBM_3; pfam00942 1150475005516 Tic20-like protein; Region: Tic20; pfam09685 1150475005517 HAMP domain; Region: HAMP; pfam00672 1150475005518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475005519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475005520 dimer interface [polypeptide binding]; other site 1150475005521 phosphorylation site [posttranslational modification] 1150475005522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475005523 ATP binding site [chemical binding]; other site 1150475005524 Mg2+ binding site [ion binding]; other site 1150475005525 G-X-G motif; other site 1150475005526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475005527 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475005528 active site 1150475005529 phosphorylation site [posttranslational modification] 1150475005530 intermolecular recognition site; other site 1150475005531 dimerization interface [polypeptide binding]; other site 1150475005532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475005533 DNA binding site [nucleotide binding] 1150475005534 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1150475005535 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1150475005536 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1150475005537 substrate binding site [chemical binding]; other site 1150475005538 active site 1150475005539 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1150475005540 metal binding site [ion binding]; metal-binding site 1150475005541 ligand binding site [chemical binding]; other site 1150475005542 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005543 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1150475005544 acyl-activating enzyme (AAE) consensus motif; other site 1150475005545 AMP binding site [chemical binding]; other site 1150475005546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005547 Condensation domain; Region: Condensation; pfam00668 1150475005548 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1150475005549 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005550 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475005551 Condensation domain; Region: Condensation; pfam00668 1150475005552 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005553 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005554 acyl-activating enzyme (AAE) consensus motif; other site 1150475005555 AMP binding site [chemical binding]; other site 1150475005556 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005557 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1150475005558 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005559 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005560 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1150475005561 acyl-activating enzyme (AAE) consensus motif; other site 1150475005562 AMP binding site [chemical binding]; other site 1150475005563 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005564 Condensation domain; Region: Condensation; pfam00668 1150475005565 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005566 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475005567 Condensation domain; Region: Condensation; pfam00668 1150475005568 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005569 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005570 acyl-activating enzyme (AAE) consensus motif; other site 1150475005571 AMP binding site [chemical binding]; other site 1150475005572 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005573 Condensation domain; Region: Condensation; pfam00668 1150475005574 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005575 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475005576 Condensation domain; Region: Condensation; pfam00668 1150475005577 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005578 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005579 acyl-activating enzyme (AAE) consensus motif; other site 1150475005580 AMP binding site [chemical binding]; other site 1150475005581 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005582 Condensation domain; Region: Condensation; pfam00668 1150475005583 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005584 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005585 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005586 acyl-activating enzyme (AAE) consensus motif; other site 1150475005587 AMP binding site [chemical binding]; other site 1150475005588 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005589 Condensation domain; Region: Condensation; pfam00668 1150475005590 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005591 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005592 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1150475005593 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1150475005594 acyl-activating enzyme (AAE) consensus motif; other site 1150475005595 putative AMP binding site [chemical binding]; other site 1150475005596 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005597 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475005598 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475005599 active site 1150475005600 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005601 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1150475005602 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475005603 inhibitor-cofactor binding pocket; inhibition site 1150475005604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475005605 catalytic residue [active] 1150475005606 Condensation domain; Region: Condensation; pfam00668 1150475005607 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005608 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005609 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005610 Condensation domain; Region: Condensation; pfam00668 1150475005611 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005612 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005614 acyl-activating enzyme (AAE) consensus motif; other site 1150475005615 AMP binding site [chemical binding]; other site 1150475005616 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005617 Condensation domain; Region: Condensation; pfam00668 1150475005618 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005619 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005620 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1150475005621 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1150475005622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475005623 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1150475005624 NAD(P) binding site [chemical binding]; other site 1150475005625 active site 1150475005626 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1150475005627 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1150475005628 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1150475005629 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1150475005630 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1150475005631 Cytochrome P450; Region: p450; cl12078 1150475005632 biotin synthase; Validated; Region: PRK06256 1150475005633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475005634 FeS/SAM binding site; other site 1150475005635 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1150475005636 AAA domain; Region: AAA_26; pfam13500 1150475005637 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1150475005638 active site 1150475005639 ADP binding site [chemical binding]; other site 1150475005640 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1150475005641 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1150475005642 substrate-cofactor binding pocket; other site 1150475005643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475005644 catalytic residue [active] 1150475005645 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1150475005646 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475005647 inhibitor-cofactor binding pocket; inhibition site 1150475005648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475005649 catalytic residue [active] 1150475005650 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1150475005651 Predicted membrane protein [Function unknown]; Region: COG2246 1150475005652 GtrA-like protein; Region: GtrA; pfam04138 1150475005653 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1150475005654 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1150475005655 active site 1150475005656 tetramer interface; other site 1150475005657 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1150475005658 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1150475005659 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1150475005660 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1150475005661 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1150475005662 enoyl-CoA hydratase; Provisional; Region: PRK07657 1150475005663 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1150475005664 substrate binding site [chemical binding]; other site 1150475005665 oxyanion hole (OAH) forming residues; other site 1150475005666 trimer interface [polypeptide binding]; other site 1150475005667 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1150475005668 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1150475005669 active site 1150475005670 catalytic residues [active] 1150475005671 metal binding site [ion binding]; metal-binding site 1150475005672 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1150475005673 carboxyltransferase (CT) interaction site; other site 1150475005674 biotinylation site [posttranslational modification]; other site 1150475005675 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1150475005676 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1150475005677 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1150475005678 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1150475005679 AMP-binding domain protein; Validated; Region: PRK08315 1150475005680 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1150475005681 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1150475005682 acyl-activating enzyme (AAE) consensus motif; other site 1150475005683 putative AMP binding site [chemical binding]; other site 1150475005684 putative active site [active] 1150475005685 putative CoA binding site [chemical binding]; other site 1150475005686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1150475005687 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1150475005688 FAD binding site [chemical binding]; other site 1150475005689 homotetramer interface [polypeptide binding]; other site 1150475005690 substrate binding pocket [chemical binding]; other site 1150475005691 catalytic base [active] 1150475005692 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1150475005693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1150475005694 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1150475005695 Condensation domain; Region: Condensation; pfam00668 1150475005696 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005697 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1150475005698 acyl-activating enzyme (AAE) consensus motif; other site 1150475005699 AMP binding site [chemical binding]; other site 1150475005700 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005701 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1150475005702 Condensation domain; Region: Condensation; pfam00668 1150475005703 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005704 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005705 acyl-activating enzyme (AAE) consensus motif; other site 1150475005706 AMP binding site [chemical binding]; other site 1150475005707 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005708 Condensation domain; Region: Condensation; pfam00668 1150475005709 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005710 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005711 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005712 acyl-activating enzyme (AAE) consensus motif; other site 1150475005713 AMP binding site [chemical binding]; other site 1150475005714 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005715 Condensation domain; Region: Condensation; pfam00668 1150475005716 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005717 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005718 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005719 acyl-activating enzyme (AAE) consensus motif; other site 1150475005720 AMP binding site [chemical binding]; other site 1150475005721 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005722 Condensation domain; Region: Condensation; pfam00668 1150475005723 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475005724 Condensation domain; Region: Condensation; pfam00668 1150475005725 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005726 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005727 acyl-activating enzyme (AAE) consensus motif; other site 1150475005728 AMP binding site [chemical binding]; other site 1150475005729 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005730 Condensation domain; Region: Condensation; pfam00668 1150475005731 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005732 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005733 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1150475005734 acyl-activating enzyme (AAE) consensus motif; other site 1150475005735 AMP binding site [chemical binding]; other site 1150475005736 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005737 Condensation domain; Region: Condensation; pfam00668 1150475005738 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475005739 Condensation domain; Region: Condensation; pfam00668 1150475005740 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005741 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005742 acyl-activating enzyme (AAE) consensus motif; other site 1150475005743 AMP binding site [chemical binding]; other site 1150475005744 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005745 Condensation domain; Region: Condensation; pfam00668 1150475005746 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005747 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005748 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475005749 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005750 acyl-activating enzyme (AAE) consensus motif; other site 1150475005751 AMP binding site [chemical binding]; other site 1150475005752 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005753 Condensation domain; Region: Condensation; pfam00668 1150475005754 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475005755 Condensation domain; Region: Condensation; pfam00668 1150475005756 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005757 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005758 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005759 acyl-activating enzyme (AAE) consensus motif; other site 1150475005760 AMP binding site [chemical binding]; other site 1150475005761 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005762 Condensation domain; Region: Condensation; pfam00668 1150475005763 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005764 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475005765 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475005766 acyl-activating enzyme (AAE) consensus motif; other site 1150475005767 AMP binding site [chemical binding]; other site 1150475005768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475005769 Condensation domain; Region: Condensation; pfam00668 1150475005770 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475005771 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1150475005772 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1150475005773 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1150475005774 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1150475005775 active site 1150475005776 catalytic residues [active] 1150475005777 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1150475005778 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1150475005779 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1150475005780 Int/Topo IB signature motif; other site 1150475005781 Helix-turn-helix domain; Region: HTH_17; cl17695 1150475005782 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1150475005783 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1150475005784 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475005785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475005786 putative substrate translocation pore; other site 1150475005787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475005788 dimerization interface [polypeptide binding]; other site 1150475005789 putative DNA binding site [nucleotide binding]; other site 1150475005790 putative Zn2+ binding site [ion binding]; other site 1150475005791 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1150475005792 anticodon binding site; other site 1150475005793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475005794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475005795 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1150475005796 putative dimerization interface [polypeptide binding]; other site 1150475005797 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1150475005798 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1150475005799 NAD(P) binding site [chemical binding]; other site 1150475005800 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1150475005801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1150475005802 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1150475005803 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1150475005804 active site 1150475005805 dimer interface [polypeptide binding]; other site 1150475005806 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1150475005807 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1150475005808 active site 1150475005809 FMN binding site [chemical binding]; other site 1150475005810 substrate binding site [chemical binding]; other site 1150475005811 3Fe-4S cluster binding site [ion binding]; other site 1150475005812 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1150475005813 domain interface; other site 1150475005814 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475005815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475005816 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1150475005817 putative dimerization interface [polypeptide binding]; other site 1150475005818 gamma-glutamyl kinase; Provisional; Region: PRK13402 1150475005819 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1150475005820 nucleotide binding site [chemical binding]; other site 1150475005821 homotetrameric interface [polypeptide binding]; other site 1150475005822 putative phosphate binding site [ion binding]; other site 1150475005823 putative allosteric binding site; other site 1150475005824 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1150475005825 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1150475005826 Replication terminator protein; Region: RTP; pfam02334 1150475005827 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1150475005828 classical (c) SDRs; Region: SDR_c; cd05233 1150475005829 NAD(P) binding site [chemical binding]; other site 1150475005830 active site 1150475005831 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1150475005832 polyol permease family; Region: 2A0118; TIGR00897 1150475005833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475005834 putative substrate translocation pore; other site 1150475005835 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1150475005836 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1150475005837 putative N- and C-terminal domain interface [polypeptide binding]; other site 1150475005838 putative active site [active] 1150475005839 putative MgATP binding site [chemical binding]; other site 1150475005840 catalytic site [active] 1150475005841 metal binding site [ion binding]; metal-binding site 1150475005842 carbohydrate binding site [chemical binding]; other site 1150475005843 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1150475005844 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1150475005845 putative ligand binding site [chemical binding]; other site 1150475005846 putative NAD binding site [chemical binding]; other site 1150475005847 catalytic site [active] 1150475005848 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1150475005849 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1150475005850 putative [4Fe-4S] binding site [ion binding]; other site 1150475005851 putative molybdopterin cofactor binding site [chemical binding]; other site 1150475005852 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1150475005853 putative molybdopterin cofactor binding site; other site 1150475005854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475005855 MarR family; Region: MarR_2; pfam12802 1150475005856 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1150475005857 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1150475005858 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1150475005859 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1150475005860 dimer interface [polypeptide binding]; other site 1150475005861 putative tRNA-binding site [nucleotide binding]; other site 1150475005862 Cupin domain; Region: Cupin_2; pfam07883 1150475005863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1150475005864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1150475005865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1150475005866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475005867 WHG domain; Region: WHG; pfam13305 1150475005868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1150475005869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475005870 dimerization interface [polypeptide binding]; other site 1150475005871 putative DNA binding site [nucleotide binding]; other site 1150475005872 putative Zn2+ binding site [ion binding]; other site 1150475005873 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1150475005874 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1150475005875 catalytic residue [active] 1150475005876 Predicted membrane protein [Function unknown]; Region: COG2322 1150475005877 Protein required for attachment to host cells; Region: Host_attach; cl02398 1150475005878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1150475005879 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1150475005880 putative dimer interface [polypeptide binding]; other site 1150475005881 catalytic triad [active] 1150475005882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475005883 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475005884 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475005885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1150475005886 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1150475005887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475005888 ATP binding site [chemical binding]; other site 1150475005889 putative Mg++ binding site [ion binding]; other site 1150475005890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475005891 nucleotide binding region [chemical binding]; other site 1150475005892 ATP-binding site [chemical binding]; other site 1150475005893 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1150475005894 HRDC domain; Region: HRDC; pfam00570 1150475005895 azoreductase; Provisional; Region: PRK13556 1150475005896 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1150475005897 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1150475005898 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1150475005899 putative dimer interface [polypeptide binding]; other site 1150475005900 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1150475005901 pentamer interface [polypeptide binding]; other site 1150475005902 dodecaamer interface [polypeptide binding]; other site 1150475005903 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1150475005904 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1150475005905 NAD(P) binding site [chemical binding]; other site 1150475005906 catalytic residues [active] 1150475005907 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1150475005908 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1150475005909 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1150475005910 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1150475005911 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1150475005912 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1150475005913 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1150475005914 Na2 binding site [ion binding]; other site 1150475005915 putative substrate binding site 1 [chemical binding]; other site 1150475005916 Na binding site 1 [ion binding]; other site 1150475005917 putative substrate binding site 2 [chemical binding]; other site 1150475005918 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1150475005919 Sodium Bile acid symporter family; Region: SBF; pfam01758 1150475005920 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1150475005921 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1150475005922 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1150475005923 E3 interaction surface; other site 1150475005924 lipoyl attachment site [posttranslational modification]; other site 1150475005925 e3 binding domain; Region: E3_binding; pfam02817 1150475005926 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1150475005927 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1150475005928 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1150475005929 TPP-binding site [chemical binding]; other site 1150475005930 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1150475005931 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1150475005932 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1150475005933 metal ion-dependent adhesion site (MIDAS); other site 1150475005934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475005935 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1150475005936 Walker A motif; other site 1150475005937 ATP binding site [chemical binding]; other site 1150475005938 Walker B motif; other site 1150475005939 arginine finger; other site 1150475005940 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1150475005941 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1150475005942 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1150475005943 E-class dimer interface [polypeptide binding]; other site 1150475005944 P-class dimer interface [polypeptide binding]; other site 1150475005945 active site 1150475005946 Cu2+ binding site [ion binding]; other site 1150475005947 Zn2+ binding site [ion binding]; other site 1150475005948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475005949 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475005950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475005951 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475005952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475005953 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475005954 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475005955 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1150475005956 NlpC/P60 family; Region: NLPC_P60; pfam00877 1150475005957 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1150475005958 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1150475005959 active site 1150475005960 TDP-binding site; other site 1150475005961 acceptor substrate-binding pocket; other site 1150475005962 homodimer interface [polypeptide binding]; other site 1150475005963 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1150475005964 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1150475005965 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1150475005966 multidrug efflux protein; Reviewed; Region: PRK01766 1150475005967 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1150475005968 cation binding site [ion binding]; other site 1150475005969 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1150475005970 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1150475005971 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1150475005972 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1150475005973 EamA-like transporter family; Region: EamA; pfam00892 1150475005974 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1150475005975 Predicted transcriptional regulators [Transcription]; Region: COG1733 1150475005976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475005977 dimerization interface [polypeptide binding]; other site 1150475005978 putative DNA binding site [nucleotide binding]; other site 1150475005979 putative Zn2+ binding site [ion binding]; other site 1150475005980 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1150475005981 dimer interface [polypeptide binding]; other site 1150475005982 FMN binding site [chemical binding]; other site 1150475005983 Predicted esterase [General function prediction only]; Region: COG0400 1150475005984 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1150475005985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475005986 Zn binding site [ion binding]; other site 1150475005987 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1150475005988 Zn binding site [ion binding]; other site 1150475005989 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1150475005990 Na binding site [ion binding]; other site 1150475005991 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1150475005992 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1150475005993 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1150475005994 beta-galactosidase; Region: BGL; TIGR03356 1150475005995 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1150475005996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475005997 DNA-binding site [nucleotide binding]; DNA binding site 1150475005998 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1150475005999 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1150475006000 C-terminal peptidase (prc); Region: prc; TIGR00225 1150475006001 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1150475006002 protein binding site [polypeptide binding]; other site 1150475006003 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1150475006004 Catalytic dyad [active] 1150475006005 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1150475006006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475006007 S-adenosylmethionine binding site [chemical binding]; other site 1150475006008 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1150475006009 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1150475006010 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1150475006011 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1150475006012 YodL-like; Region: YodL; pfam14191 1150475006013 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1150475006014 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1150475006015 active site 1150475006016 YozD-like protein; Region: YozD; pfam14162 1150475006017 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1150475006018 hypothetical protein; Provisional; Region: PRK13672 1150475006019 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1150475006020 Zn binding site [ion binding]; other site 1150475006021 toxin interface [polypeptide binding]; other site 1150475006022 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1150475006023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475006024 FeS/SAM binding site; other site 1150475006025 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1150475006026 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1150475006027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475006028 Coenzyme A binding pocket [chemical binding]; other site 1150475006029 acetylornithine deacetylase; Validated; Region: PRK06915 1150475006030 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1150475006031 metal binding site [ion binding]; metal-binding site 1150475006032 dimer interface [polypeptide binding]; other site 1150475006033 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1150475006034 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1150475006035 hypothetical protein; Provisional; Region: PRK06917 1150475006036 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475006037 inhibitor-cofactor binding pocket; inhibition site 1150475006038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475006039 catalytic residue [active] 1150475006040 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1150475006041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475006042 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1150475006043 Coenzyme A binding pocket [chemical binding]; other site 1150475006044 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1150475006045 active site 1150475006046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1150475006047 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1150475006048 Phytase; Region: Phytase; cl17685 1150475006049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475006050 NAD(P) binding site [chemical binding]; other site 1150475006051 active site 1150475006052 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1150475006053 YoqO-like protein; Region: YoqO; pfam14037 1150475006054 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475006055 Evidence 5 : No homology to any previously reported sequences 1150475006056 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1150475006057 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1150475006058 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1150475006059 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1150475006060 Staphylococcal nuclease homologues; Region: SNc; smart00318 1150475006061 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1150475006062 Catalytic site; other site 1150475006063 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1150475006064 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1150475006065 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1150475006066 catalytic residues [active] 1150475006067 catalytic nucleophile [active] 1150475006068 Recombinase; Region: Recombinase; pfam07508 1150475006069 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1150475006070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475006071 active site 1150475006072 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1150475006073 SelR domain; Region: SelR; pfam01641 1150475006074 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1150475006075 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475006076 MarR family; Region: MarR; pfam01047 1150475006077 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1150475006078 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1150475006079 active site 1150475006080 catalytic triad [active] 1150475006081 oxyanion hole [active] 1150475006082 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1150475006083 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1150475006084 Cu(I) binding site [ion binding]; other site 1150475006085 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1150475006086 threonine dehydratase; Validated; Region: PRK08639 1150475006087 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1150475006088 tetramer interface [polypeptide binding]; other site 1150475006089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475006090 catalytic residue [active] 1150475006091 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1150475006092 putative Ile/Val binding site [chemical binding]; other site 1150475006093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475006094 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1150475006095 Walker A motif; other site 1150475006096 ATP binding site [chemical binding]; other site 1150475006097 Walker B motif; other site 1150475006098 arginine finger; other site 1150475006099 Haemolysin-III related; Region: HlyIII; cl03831 1150475006100 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1150475006101 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1150475006102 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1150475006103 putative acyl-acceptor binding pocket; other site 1150475006104 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1150475006105 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1150475006106 folate binding site [chemical binding]; other site 1150475006107 NADP+ binding site [chemical binding]; other site 1150475006108 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1150475006109 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1150475006110 dimerization interface [polypeptide binding]; other site 1150475006111 active site 1150475006112 YpjP-like protein; Region: YpjP; pfam14005 1150475006113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475006114 S-adenosylmethionine binding site [chemical binding]; other site 1150475006115 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1150475006116 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1150475006117 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1150475006118 Virulence factor; Region: Virulence_fact; pfam13769 1150475006119 HEAT repeats; Region: HEAT_2; pfam13646 1150475006120 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1150475006121 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1150475006122 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1150475006123 Zn2+ binding site [ion binding]; other site 1150475006124 Mg2+ binding site [ion binding]; other site 1150475006125 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1150475006126 catalytic residues [active] 1150475006127 dimer interface [polypeptide binding]; other site 1150475006128 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1150475006129 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1150475006130 proposed active site lysine [active] 1150475006131 conserved cys residue [active] 1150475006132 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1150475006133 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1150475006134 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1150475006135 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1150475006136 DNA-binding site [nucleotide binding]; DNA binding site 1150475006137 RNA-binding motif; other site 1150475006138 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1150475006139 hypothetical protein; Validated; Region: PRK07708 1150475006140 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1150475006141 RNA/DNA hybrid binding site [nucleotide binding]; other site 1150475006142 active site 1150475006143 conserved hypothetical integral membrane protein; Region: TIGR00697 1150475006144 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1150475006145 RNA/DNA hybrid binding site [nucleotide binding]; other site 1150475006146 active site 1150475006147 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1150475006148 5'-3' exonuclease; Region: 53EXOc; smart00475 1150475006149 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1150475006150 active site 1150475006151 metal binding site 1 [ion binding]; metal-binding site 1150475006152 putative 5' ssDNA interaction site; other site 1150475006153 metal binding site 3; metal-binding site 1150475006154 metal binding site 2 [ion binding]; metal-binding site 1150475006155 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1150475006156 putative DNA binding site [nucleotide binding]; other site 1150475006157 putative metal binding site [ion binding]; other site 1150475006158 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1150475006159 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1150475006160 Dynamin family; Region: Dynamin_N; pfam00350 1150475006161 G1 box; other site 1150475006162 GTP/Mg2+ binding site [chemical binding]; other site 1150475006163 G2 box; other site 1150475006164 Switch I region; other site 1150475006165 G3 box; other site 1150475006166 Switch II region; other site 1150475006167 G4 box; other site 1150475006168 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1150475006169 G1 box; other site 1150475006170 GTP/Mg2+ binding site [chemical binding]; other site 1150475006171 Dynamin family; Region: Dynamin_N; pfam00350 1150475006172 G2 box; other site 1150475006173 Switch I region; other site 1150475006174 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1150475006175 G3 box; other site 1150475006176 Switch II region; other site 1150475006177 GTP/Mg2+ binding site [chemical binding]; other site 1150475006178 G4 box; other site 1150475006179 G5 box; other site 1150475006180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1150475006181 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1150475006182 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1150475006183 malonyl-CoA binding site [chemical binding]; other site 1150475006184 dimer interface [polypeptide binding]; other site 1150475006185 active site 1150475006186 product binding site; other site 1150475006187 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1150475006188 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1150475006189 DNA binding site [nucleotide binding] 1150475006190 active site 1150475006191 Predicted membrane protein [Function unknown]; Region: COG2323 1150475006192 Isochorismatase family; Region: Isochorismatase; pfam00857 1150475006193 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1150475006194 catalytic triad [active] 1150475006195 conserved cis-peptide bond; other site 1150475006196 xanthine permease; Region: pbuX; TIGR03173 1150475006197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475006198 active site 1150475006199 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1150475006200 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1150475006201 active site 1150475006202 Zn binding site [ion binding]; other site 1150475006203 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1150475006204 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1150475006205 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1150475006206 YpzG-like protein; Region: YpzG; pfam14139 1150475006207 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1150475006208 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1150475006209 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1150475006210 cell division protein GpsB; Provisional; Region: PRK14127 1150475006211 DivIVA domain; Region: DivI1A_domain; TIGR03544 1150475006212 hypothetical protein; Provisional; Region: PRK13660 1150475006213 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1150475006214 RNase_H superfamily; Region: RNase_H_2; pfam13482 1150475006215 active site 1150475006216 substrate binding site [chemical binding]; other site 1150475006217 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1150475006218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475006219 ATP binding site [chemical binding]; other site 1150475006220 putative Mg++ binding site [ion binding]; other site 1150475006221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475006222 nucleotide binding region [chemical binding]; other site 1150475006223 ATP-binding site [chemical binding]; other site 1150475006224 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1150475006225 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1150475006226 HPr interaction site; other site 1150475006227 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1150475006228 active site 1150475006229 phosphorylation site [posttranslational modification] 1150475006230 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1150475006231 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1150475006232 putative dimer interface [polypeptide binding]; other site 1150475006233 YppG-like protein; Region: YppG; pfam14179 1150475006234 YppF-like protein; Region: YppF; pfam14178 1150475006235 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1150475006236 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1150475006237 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1150475006238 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1150475006239 Transglycosylase; Region: Transgly; pfam00912 1150475006240 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1150475006241 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1150475006242 Interdomain contacts; other site 1150475006243 Cytokine receptor motif; other site 1150475006244 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1150475006245 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1150475006246 minor groove reading motif; other site 1150475006247 helix-hairpin-helix signature motif; other site 1150475006248 substrate binding pocket [chemical binding]; other site 1150475006249 active site 1150475006250 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1150475006251 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1150475006252 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1150475006253 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1150475006254 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1150475006255 putative dimer interface [polypeptide binding]; other site 1150475006256 putative anticodon binding site; other site 1150475006257 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1150475006258 homodimer interface [polypeptide binding]; other site 1150475006259 motif 1; other site 1150475006260 motif 2; other site 1150475006261 active site 1150475006262 motif 3; other site 1150475006263 aspartate aminotransferase; Provisional; Region: PRK05764 1150475006264 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475006265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475006266 homodimer interface [polypeptide binding]; other site 1150475006267 catalytic residue [active] 1150475006268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1150475006269 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1150475006270 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1150475006271 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1150475006272 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1150475006273 active site 1150475006274 catalytic site [active] 1150475006275 substrate binding site [chemical binding]; other site 1150475006276 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1150475006277 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1150475006278 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1150475006279 tetramerization interface [polypeptide binding]; other site 1150475006280 active site 1150475006281 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1150475006282 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1150475006283 active site 1150475006284 ATP-binding site [chemical binding]; other site 1150475006285 pantoate-binding site; other site 1150475006286 HXXH motif; other site 1150475006287 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1150475006288 oligomerization interface [polypeptide binding]; other site 1150475006289 active site 1150475006290 metal binding site [ion binding]; metal-binding site 1150475006291 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1150475006292 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1150475006293 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1150475006294 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1150475006295 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1150475006296 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1150475006297 active site 1150475006298 NTP binding site [chemical binding]; other site 1150475006299 metal binding triad [ion binding]; metal-binding site 1150475006300 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1150475006301 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1150475006302 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1150475006303 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1150475006304 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1150475006305 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1150475006306 active site 1150475006307 dimer interfaces [polypeptide binding]; other site 1150475006308 catalytic residues [active] 1150475006309 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1150475006310 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1150475006311 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1150475006312 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1150475006313 homodimer interface [polypeptide binding]; other site 1150475006314 metal binding site [ion binding]; metal-binding site 1150475006315 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1150475006316 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475006317 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475006318 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1150475006319 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1150475006320 Cupin; Region: Cupin_1; smart00835 1150475006321 Cupin; Region: Cupin_1; smart00835 1150475006322 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1150475006323 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1150475006324 Qo binding site; other site 1150475006325 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1150475006326 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1150475006327 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1150475006328 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1150475006329 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1150475006330 interchain domain interface [polypeptide binding]; other site 1150475006331 intrachain domain interface; other site 1150475006332 heme bH binding site [chemical binding]; other site 1150475006333 Qi binding site; other site 1150475006334 heme bL binding site [chemical binding]; other site 1150475006335 Qo binding site; other site 1150475006336 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1150475006337 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1150475006338 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1150475006339 iron-sulfur cluster [ion binding]; other site 1150475006340 [2Fe-2S] cluster binding site [ion binding]; other site 1150475006341 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1150475006342 hypothetical protein; Provisional; Region: PRK03636 1150475006343 UPF0302 domain; Region: UPF0302; pfam08864 1150475006344 A short protein domain of unknown function; Region: IDEAL; smart00914 1150475006345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1150475006346 TPR motif; other site 1150475006347 binding surface 1150475006348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1150475006349 binding surface 1150475006350 TPR motif; other site 1150475006351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475006352 TPR motif; other site 1150475006353 binding surface 1150475006354 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1150475006355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475006356 binding surface 1150475006357 TPR motif; other site 1150475006358 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1150475006359 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1150475006360 hinge; other site 1150475006361 active site 1150475006362 prephenate dehydrogenase; Validated; Region: PRK06545 1150475006363 prephenate dehydrogenase; Validated; Region: PRK08507 1150475006364 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1150475006365 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1150475006366 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475006367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475006368 homodimer interface [polypeptide binding]; other site 1150475006369 catalytic residue [active] 1150475006370 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1150475006371 substrate binding site [chemical binding]; other site 1150475006372 active site 1150475006373 catalytic residues [active] 1150475006374 heterodimer interface [polypeptide binding]; other site 1150475006375 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1150475006376 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1150475006377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475006378 catalytic residue [active] 1150475006379 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1150475006380 active site 1150475006381 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1150475006382 active site 1150475006383 ribulose/triose binding site [chemical binding]; other site 1150475006384 phosphate binding site [ion binding]; other site 1150475006385 substrate (anthranilate) binding pocket [chemical binding]; other site 1150475006386 product (indole) binding pocket [chemical binding]; other site 1150475006387 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1150475006388 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1150475006389 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1150475006390 anthranilate synthase component I; Provisional; Region: PRK13569 1150475006391 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1150475006392 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1150475006393 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1150475006394 homotrimer interaction site [polypeptide binding]; other site 1150475006395 active site 1150475006396 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1150475006397 active site 1150475006398 dimer interface [polypeptide binding]; other site 1150475006399 metal binding site [ion binding]; metal-binding site 1150475006400 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1150475006401 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1150475006402 Tetramer interface [polypeptide binding]; other site 1150475006403 active site 1150475006404 FMN-binding site [chemical binding]; other site 1150475006405 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1150475006406 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1150475006407 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1150475006408 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1150475006409 active site 1150475006410 multimer interface [polypeptide binding]; other site 1150475006411 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1150475006412 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1150475006413 substrate binding pocket [chemical binding]; other site 1150475006414 chain length determination region; other site 1150475006415 substrate-Mg2+ binding site; other site 1150475006416 catalytic residues [active] 1150475006417 aspartate-rich region 1; other site 1150475006418 active site lid residues [active] 1150475006419 aspartate-rich region 2; other site 1150475006420 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1150475006421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475006422 S-adenosylmethionine binding site [chemical binding]; other site 1150475006423 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1150475006424 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1150475006425 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1150475006426 homodecamer interface [polypeptide binding]; other site 1150475006427 GTP cyclohydrolase I; Provisional; Region: PLN03044 1150475006428 active site 1150475006429 putative catalytic site residues [active] 1150475006430 zinc binding site [ion binding]; other site 1150475006431 GTP-CH-I/GFRP interaction surface; other site 1150475006432 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1150475006433 IHF dimer interface [polypeptide binding]; other site 1150475006434 IHF - DNA interface [nucleotide binding]; other site 1150475006435 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1150475006436 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1150475006437 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1150475006438 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1150475006439 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1150475006440 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1150475006441 GTP-binding protein Der; Reviewed; Region: PRK00093 1150475006442 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1150475006443 G1 box; other site 1150475006444 GTP/Mg2+ binding site [chemical binding]; other site 1150475006445 Switch I region; other site 1150475006446 G2 box; other site 1150475006447 Switch II region; other site 1150475006448 G3 box; other site 1150475006449 G4 box; other site 1150475006450 G5 box; other site 1150475006451 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1150475006452 G1 box; other site 1150475006453 GTP/Mg2+ binding site [chemical binding]; other site 1150475006454 Switch I region; other site 1150475006455 G2 box; other site 1150475006456 G3 box; other site 1150475006457 Switch II region; other site 1150475006458 G4 box; other site 1150475006459 G5 box; other site 1150475006460 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1150475006461 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1150475006462 homotetramer interface [polypeptide binding]; other site 1150475006463 FMN binding site [chemical binding]; other site 1150475006464 homodimer contacts [polypeptide binding]; other site 1150475006465 putative active site [active] 1150475006466 putative substrate binding site [chemical binding]; other site 1150475006467 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1150475006468 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1150475006469 RNA binding site [nucleotide binding]; other site 1150475006470 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1150475006471 RNA binding site [nucleotide binding]; other site 1150475006472 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1150475006473 RNA binding site [nucleotide binding]; other site 1150475006474 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1150475006475 RNA binding site [nucleotide binding]; other site 1150475006476 cytidylate kinase; Provisional; Region: cmk; PRK00023 1150475006477 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1150475006478 CMP-binding site; other site 1150475006479 The sites determining sugar specificity; other site 1150475006480 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1150475006481 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1150475006482 PilZ domain; Region: PilZ; pfam07238 1150475006483 germination protein YpeB; Region: spore_YpeB; TIGR02889 1150475006484 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1150475006485 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1150475006486 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1150475006487 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1150475006488 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1150475006489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1150475006490 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1150475006491 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1150475006492 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1150475006493 NAD(P) binding site [chemical binding]; other site 1150475006494 adaptor protein; Provisional; Region: PRK02899 1150475006495 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1150475006496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1150475006497 putative active site [active] 1150475006498 putative metal binding site [ion binding]; other site 1150475006499 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1150475006500 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475006501 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475006502 CAAX protease self-immunity; Region: Abi; pfam02517 1150475006503 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1150475006504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475006505 ATP binding site [chemical binding]; other site 1150475006506 putative Mg++ binding site [ion binding]; other site 1150475006507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475006508 nucleotide binding region [chemical binding]; other site 1150475006509 ATP-binding site [chemical binding]; other site 1150475006510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1150475006511 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1150475006512 Predicted membrane protein [Function unknown]; Region: COG3601 1150475006513 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1150475006514 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1150475006515 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1150475006516 ligand binding site [chemical binding]; other site 1150475006517 NAD binding site [chemical binding]; other site 1150475006518 dimerization interface [polypeptide binding]; other site 1150475006519 catalytic site [active] 1150475006520 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1150475006521 putative L-serine binding site [chemical binding]; other site 1150475006522 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1150475006523 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475006524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475006525 DNA binding residues [nucleotide binding] 1150475006526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1150475006527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475006528 dimerization interface [polypeptide binding]; other site 1150475006529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475006530 putative active site [active] 1150475006531 heme pocket [chemical binding]; other site 1150475006532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475006533 dimer interface [polypeptide binding]; other site 1150475006534 phosphorylation site [posttranslational modification] 1150475006535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475006536 ATP binding site [chemical binding]; other site 1150475006537 Mg2+ binding site [ion binding]; other site 1150475006538 G-X-G motif; other site 1150475006539 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475006540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475006541 active site 1150475006542 phosphorylation site [posttranslational modification] 1150475006543 intermolecular recognition site; other site 1150475006544 dimerization interface [polypeptide binding]; other site 1150475006545 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475006546 DNA binding site [nucleotide binding] 1150475006547 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1150475006548 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1150475006549 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1150475006550 ResB-like family; Region: ResB; pfam05140 1150475006551 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1150475006552 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1150475006553 catalytic residues [active] 1150475006554 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1150475006555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1150475006556 RNA binding surface [nucleotide binding]; other site 1150475006557 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1150475006558 active site 1150475006559 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1150475006560 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1150475006561 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1150475006562 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1150475006563 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1150475006564 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1150475006565 segregation and condensation protein B; Region: TIGR00281 1150475006566 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1150475006567 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1150475006568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475006569 Coenzyme A binding pocket [chemical binding]; other site 1150475006570 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1150475006571 homopentamer interface [polypeptide binding]; other site 1150475006572 active site 1150475006573 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1150475006574 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1150475006575 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1150475006576 dimerization interface [polypeptide binding]; other site 1150475006577 active site 1150475006578 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1150475006579 Lumazine binding domain; Region: Lum_binding; pfam00677 1150475006580 Lumazine binding domain; Region: Lum_binding; pfam00677 1150475006581 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1150475006582 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1150475006583 catalytic motif [active] 1150475006584 Zn binding site [ion binding]; other site 1150475006585 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1150475006586 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1150475006587 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1150475006588 Catalytic site [active] 1150475006589 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1150475006590 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1150475006591 active site 1150475006592 Predicted secreted protein [Function unknown]; Region: COG4086 1150475006593 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1150475006594 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1150475006595 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1150475006596 active site 1150475006597 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1150475006598 substrate binding site [chemical binding]; other site 1150475006599 catalytic residues [active] 1150475006600 dimer interface [polypeptide binding]; other site 1150475006601 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1150475006602 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1150475006603 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1150475006604 stage V sporulation protein AD; Validated; Region: PRK08304 1150475006605 stage V sporulation protein AD; Provisional; Region: PRK12404 1150475006606 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1150475006607 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1150475006608 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1150475006609 sporulation sigma factor SigF; Validated; Region: PRK05572 1150475006610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475006611 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1150475006612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475006613 DNA binding residues [nucleotide binding] 1150475006614 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1150475006615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475006616 ATP binding site [chemical binding]; other site 1150475006617 Mg2+ binding site [ion binding]; other site 1150475006618 G-X-G motif; other site 1150475006619 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1150475006620 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1150475006621 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1150475006622 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1150475006623 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1150475006624 phosphopentomutase; Provisional; Region: PRK05362 1150475006625 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1150475006626 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1150475006627 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1150475006628 active site 1150475006629 Int/Topo IB signature motif; other site 1150475006630 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1150475006631 ferric uptake regulator; Provisional; Region: fur; PRK09462 1150475006632 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1150475006633 metal binding site 2 [ion binding]; metal-binding site 1150475006634 putative DNA binding helix; other site 1150475006635 metal binding site 1 [ion binding]; metal-binding site 1150475006636 dimer interface [polypeptide binding]; other site 1150475006637 structural Zn2+ binding site [ion binding]; other site 1150475006638 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1150475006639 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1150475006640 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1150475006641 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1150475006642 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1150475006643 NAD(P) binding pocket [chemical binding]; other site 1150475006644 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1150475006645 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1150475006646 Aspartase; Region: Aspartase; cd01357 1150475006647 active sites [active] 1150475006648 tetramer interface [polypeptide binding]; other site 1150475006649 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1150475006650 active site 1150475006651 homodimer interface [polypeptide binding]; other site 1150475006652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1150475006653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475006654 non-specific DNA binding site [nucleotide binding]; other site 1150475006655 salt bridge; other site 1150475006656 sequence-specific DNA binding site [nucleotide binding]; other site 1150475006657 TIGR00375 family protein; Region: TIGR00375 1150475006658 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1150475006659 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1150475006660 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1150475006661 dimer interface [polypeptide binding]; other site 1150475006662 ADP-ribose binding site [chemical binding]; other site 1150475006663 active site 1150475006664 nudix motif; other site 1150475006665 metal binding site [ion binding]; metal-binding site 1150475006666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475006667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475006668 active site 1150475006669 catalytic tetrad [active] 1150475006670 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1150475006671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1150475006672 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1150475006673 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1150475006674 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1150475006675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1150475006676 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1150475006677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475006678 Coenzyme A binding pocket [chemical binding]; other site 1150475006679 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1150475006680 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1150475006681 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1150475006682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475006683 Coenzyme A binding pocket [chemical binding]; other site 1150475006684 DNA polymerase IV; Reviewed; Region: PRK03103 1150475006685 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1150475006686 active site 1150475006687 DNA binding site [nucleotide binding] 1150475006688 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1150475006689 YolD-like protein; Region: YolD; pfam08863 1150475006690 YqzH-like protein; Region: YqzH; pfam14164 1150475006691 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1150475006692 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1150475006693 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1150475006694 putative dimer interface [polypeptide binding]; other site 1150475006695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475006696 ligand binding site [chemical binding]; other site 1150475006697 Zn binding site [ion binding]; other site 1150475006698 pantothenate kinase; Provisional; Region: PRK05439 1150475006699 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1150475006700 ATP-binding site [chemical binding]; other site 1150475006701 CoA-binding site [chemical binding]; other site 1150475006702 Mg2+-binding site [ion binding]; other site 1150475006703 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1150475006704 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1150475006705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1150475006706 catalytic residue [active] 1150475006707 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1150475006708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475006709 NAD(P) binding site [chemical binding]; other site 1150475006710 active site 1150475006711 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1150475006712 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1150475006713 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1150475006714 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1150475006715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1150475006716 substrate binding site [chemical binding]; other site 1150475006717 oxyanion hole (OAH) forming residues; other site 1150475006718 trimer interface [polypeptide binding]; other site 1150475006719 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1150475006720 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1150475006721 dimer interface [polypeptide binding]; other site 1150475006722 active site 1150475006723 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1150475006724 Cytochrome P450; Region: p450; cl12078 1150475006725 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1150475006726 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1150475006727 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006728 polyketide synthase; Region: polyketide_synthase; cd08251 1150475006729 Enoylreductase; Region: PKS_ER; smart00829 1150475006730 putative NAD(P) binding site [chemical binding]; other site 1150475006731 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006732 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006733 active site 1150475006734 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006735 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006736 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1150475006737 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006738 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006739 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475006740 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006741 active site 1150475006742 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006743 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006744 putative NADP binding site [chemical binding]; other site 1150475006745 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475006746 active site 1150475006747 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006748 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006749 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006750 KR domain; Region: KR; pfam08659 1150475006751 putative NADP binding site [chemical binding]; other site 1150475006752 active site 1150475006753 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006754 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006755 active site 1150475006756 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006757 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475006758 putative NADP binding site [chemical binding]; other site 1150475006759 active site 1150475006760 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006761 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006762 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006763 active site 1150475006764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475006765 S-adenosylmethionine binding site [chemical binding]; other site 1150475006766 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006767 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006768 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006769 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006770 active site 1150475006771 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006772 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006773 KR domain; Region: KR; pfam08659 1150475006774 putative NADP binding site [chemical binding]; other site 1150475006775 active site 1150475006776 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006777 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006778 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006779 active site 1150475006780 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006781 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006782 putative NADP binding site [chemical binding]; other site 1150475006783 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475006784 active site 1150475006785 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006786 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475006787 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006788 active site 1150475006789 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006790 putative NADP binding site [chemical binding]; other site 1150475006791 active site 1150475006792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006793 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006794 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006795 active site 1150475006796 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006797 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006798 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006799 active site 1150475006800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006801 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1150475006802 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006803 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006804 putative NADP binding site [chemical binding]; other site 1150475006805 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475006806 active site 1150475006807 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006808 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006809 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006810 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006811 active site 1150475006812 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006813 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475006814 putative NADP binding site [chemical binding]; other site 1150475006815 active site 1150475006816 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006817 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006818 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006819 active site 1150475006820 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006821 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006822 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006823 active site 1150475006824 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006825 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006826 putative NADP binding site [chemical binding]; other site 1150475006827 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475006828 active site 1150475006829 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1150475006830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475006831 S-adenosylmethionine binding site [chemical binding]; other site 1150475006832 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1150475006833 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006834 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006835 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1150475006836 active site 1150475006837 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1150475006838 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1150475006839 putative NADP binding site [chemical binding]; other site 1150475006840 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1150475006841 active site 1150475006842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475006843 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1150475006844 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1150475006845 active site 1150475006846 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1150475006847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475006848 NAD(P) binding site [chemical binding]; other site 1150475006849 active site 1150475006850 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1150475006851 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1150475006852 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1150475006853 acyl-activating enzyme (AAE) consensus motif; other site 1150475006854 acyl-activating enzyme (AAE) consensus motif; other site 1150475006855 active site 1150475006856 AMP binding site [chemical binding]; other site 1150475006857 CoA binding site [chemical binding]; other site 1150475006858 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1150475006859 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 1150475006860 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1150475006861 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1150475006862 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1150475006863 FMN binding site [chemical binding]; other site 1150475006864 substrate binding site [chemical binding]; other site 1150475006865 putative catalytic residue [active] 1150475006866 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1150475006867 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1150475006868 Evidence 4 : Homologs of previously reported genes of unknown function 1150475006869 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1150475006870 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1150475006871 active site 1150475006872 FMN binding site [chemical binding]; other site 1150475006873 substrate binding site [chemical binding]; other site 1150475006874 homotetramer interface [polypeptide binding]; other site 1150475006875 catalytic residue [active] 1150475006876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1150475006877 ribonuclease Z; Region: RNase_Z; TIGR02651 1150475006878 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1150475006879 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1150475006880 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1150475006881 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1150475006882 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1150475006883 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1150475006884 DNA polymerase IV; Validated; Region: PRK01810 1150475006885 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1150475006886 active site 1150475006887 DNA binding site [nucleotide binding] 1150475006888 OxaA-like protein precursor; Validated; Region: PRK01622 1150475006889 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1150475006890 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1150475006891 peptidase T-like protein; Region: PepT-like; TIGR01883 1150475006892 metal binding site [ion binding]; metal-binding site 1150475006893 putative dimer interface [polypeptide binding]; other site 1150475006894 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1150475006895 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1150475006896 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1150475006897 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475006898 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1150475006899 dimer interface [polypeptide binding]; other site 1150475006900 substrate binding site [chemical binding]; other site 1150475006901 metal binding site [ion binding]; metal-binding site 1150475006902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1150475006903 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1150475006904 Predicted membrane protein [Function unknown]; Region: COG4129 1150475006905 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1150475006906 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1150475006907 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1150475006908 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1150475006909 Walker A/P-loop; other site 1150475006910 ATP binding site [chemical binding]; other site 1150475006911 Q-loop/lid; other site 1150475006912 ABC transporter signature motif; other site 1150475006913 Walker B; other site 1150475006914 D-loop; other site 1150475006915 H-loop/switch region; other site 1150475006916 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1150475006917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475006918 dimer interface [polypeptide binding]; other site 1150475006919 conserved gate region; other site 1150475006920 putative PBP binding loops; other site 1150475006921 ABC-ATPase subunit interface; other site 1150475006922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1150475006923 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1150475006924 substrate binding pocket [chemical binding]; other site 1150475006925 membrane-bound complex binding site; other site 1150475006926 hinge residues; other site 1150475006927 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1150475006928 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1150475006929 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1150475006930 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1150475006931 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1150475006932 E3 interaction surface; other site 1150475006933 lipoyl attachment site [posttranslational modification]; other site 1150475006934 e3 binding domain; Region: E3_binding; pfam02817 1150475006935 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1150475006936 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1150475006937 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1150475006938 alpha subunit interface [polypeptide binding]; other site 1150475006939 TPP binding site [chemical binding]; other site 1150475006940 heterodimer interface [polypeptide binding]; other site 1150475006941 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1150475006942 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1150475006943 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1150475006944 tetramer interface [polypeptide binding]; other site 1150475006945 TPP-binding site [chemical binding]; other site 1150475006946 heterodimer interface [polypeptide binding]; other site 1150475006947 phosphorylation loop region [posttranslational modification] 1150475006948 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1150475006949 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1150475006950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475006951 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1150475006952 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1150475006953 nucleotide binding site [chemical binding]; other site 1150475006954 Acetokinase family; Region: Acetate_kinase; cl17229 1150475006955 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1150475006956 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1150475006957 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1150475006958 NAD binding site [chemical binding]; other site 1150475006959 Phe binding site; other site 1150475006960 phosphate butyryltransferase; Validated; Region: PRK07742 1150475006961 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1150475006962 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1150475006963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475006964 putative active site [active] 1150475006965 heme pocket [chemical binding]; other site 1150475006966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475006967 putative active site [active] 1150475006968 heme pocket [chemical binding]; other site 1150475006969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475006970 Walker A motif; other site 1150475006971 ATP binding site [chemical binding]; other site 1150475006972 Walker B motif; other site 1150475006973 arginine finger; other site 1150475006974 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1150475006975 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1150475006976 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1150475006977 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1150475006978 tetramer interface [polypeptide binding]; other site 1150475006979 active site 1150475006980 Mg2+/Mn2+ binding site [ion binding]; other site 1150475006981 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1150475006982 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1150475006983 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1150475006984 dimer interface [polypeptide binding]; other site 1150475006985 Citrate synthase; Region: Citrate_synt; pfam00285 1150475006986 active site 1150475006987 coenzyme A binding site [chemical binding]; other site 1150475006988 citrylCoA binding site [chemical binding]; other site 1150475006989 oxalacetate/citrate binding site [chemical binding]; other site 1150475006990 catalytic triad [active] 1150475006991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1150475006992 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1150475006993 FAD binding site [chemical binding]; other site 1150475006994 homotetramer interface [polypeptide binding]; other site 1150475006995 substrate binding pocket [chemical binding]; other site 1150475006996 catalytic base [active] 1150475006997 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1150475006998 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1150475006999 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1150475007000 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1150475007001 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1150475007002 dimer interface [polypeptide binding]; other site 1150475007003 active site 1150475007004 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1150475007005 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1150475007006 active site 1150475007007 catalytic site [active] 1150475007008 metal binding site [ion binding]; metal-binding site 1150475007009 dimer interface [polypeptide binding]; other site 1150475007010 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1150475007011 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1150475007012 active site 1150475007013 metal binding site [ion binding]; metal-binding site 1150475007014 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1150475007015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475007016 sequence-specific DNA binding site [nucleotide binding]; other site 1150475007017 salt bridge; other site 1150475007018 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1150475007019 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1150475007020 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1150475007021 putative active site [active] 1150475007022 putative FMN binding site [chemical binding]; other site 1150475007023 putative substrate binding site [chemical binding]; other site 1150475007024 putative catalytic residue [active] 1150475007025 alanine racemase; Region: alr; TIGR00492 1150475007026 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1150475007027 active site 1150475007028 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1150475007029 dimer interface [polypeptide binding]; other site 1150475007030 substrate binding site [chemical binding]; other site 1150475007031 catalytic residues [active] 1150475007032 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1150475007033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475007034 active site 1150475007035 phosphorylation site [posttranslational modification] 1150475007036 intermolecular recognition site; other site 1150475007037 dimerization interface [polypeptide binding]; other site 1150475007038 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1150475007039 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1150475007040 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1150475007041 protein binding site [polypeptide binding]; other site 1150475007042 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1150475007043 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1150475007044 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1150475007045 Walker A/P-loop; other site 1150475007046 ATP binding site [chemical binding]; other site 1150475007047 Q-loop/lid; other site 1150475007048 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1150475007049 ABC transporter signature motif; other site 1150475007050 Walker B; other site 1150475007051 D-loop; other site 1150475007052 H-loop/switch region; other site 1150475007053 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1150475007054 arginine repressor; Provisional; Region: PRK04280 1150475007055 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1150475007056 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1150475007057 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1150475007058 RNA binding surface [nucleotide binding]; other site 1150475007059 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1150475007060 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1150475007061 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1150475007062 TPP-binding site; other site 1150475007063 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1150475007064 PYR/PP interface [polypeptide binding]; other site 1150475007065 dimer interface [polypeptide binding]; other site 1150475007066 TPP binding site [chemical binding]; other site 1150475007067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1150475007068 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1150475007069 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1150475007070 substrate binding pocket [chemical binding]; other site 1150475007071 chain length determination region; other site 1150475007072 substrate-Mg2+ binding site; other site 1150475007073 catalytic residues [active] 1150475007074 aspartate-rich region 1; other site 1150475007075 active site lid residues [active] 1150475007076 aspartate-rich region 2; other site 1150475007077 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1150475007078 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1150475007079 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1150475007080 generic binding surface II; other site 1150475007081 generic binding surface I; other site 1150475007082 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1150475007083 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1150475007084 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1150475007085 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1150475007086 homodimer interface [polypeptide binding]; other site 1150475007087 NADP binding site [chemical binding]; other site 1150475007088 substrate binding site [chemical binding]; other site 1150475007089 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1150475007090 putative RNA binding site [nucleotide binding]; other site 1150475007091 Asp23 family; Region: Asp23; pfam03780 1150475007092 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1150475007093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1150475007094 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1150475007095 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1150475007096 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1150475007097 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1150475007098 carboxyltransferase (CT) interaction site; other site 1150475007099 biotinylation site [posttranslational modification]; other site 1150475007100 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1150475007101 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1150475007102 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1150475007103 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1150475007104 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1150475007105 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1150475007106 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1150475007107 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1150475007108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475007109 Walker A motif; other site 1150475007110 ATP binding site [chemical binding]; other site 1150475007111 Walker B motif; other site 1150475007112 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1150475007113 elongation factor P; Validated; Region: PRK00529 1150475007114 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1150475007115 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1150475007116 RNA binding site [nucleotide binding]; other site 1150475007117 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1150475007118 RNA binding site [nucleotide binding]; other site 1150475007119 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1150475007120 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1150475007121 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1150475007122 active site 1150475007123 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1150475007124 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1150475007125 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1150475007126 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1150475007127 active site 1150475007128 nucleophile elbow; other site 1150475007129 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1150475007130 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1150475007131 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1150475007132 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1150475007133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1150475007134 active site residue [active] 1150475007135 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1150475007136 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1150475007137 tetramer interface [polypeptide binding]; other site 1150475007138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475007139 catalytic residue [active] 1150475007140 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1150475007141 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1150475007142 tetramer interface [polypeptide binding]; other site 1150475007143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475007144 catalytic residue [active] 1150475007145 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1150475007146 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1150475007147 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1150475007148 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1150475007149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475007150 ATP binding site [chemical binding]; other site 1150475007151 putative Mg++ binding site [ion binding]; other site 1150475007152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475007153 nucleotide binding region [chemical binding]; other site 1150475007154 ATP-binding site [chemical binding]; other site 1150475007155 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1150475007156 Anti-repressor SinI; Region: SinI; pfam08671 1150475007157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1150475007158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475007159 non-specific DNA binding site [nucleotide binding]; other site 1150475007160 salt bridge; other site 1150475007161 sequence-specific DNA binding site [nucleotide binding]; other site 1150475007162 Anti-repressor SinI; Region: SinI; pfam08671 1150475007163 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1150475007164 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1150475007165 Catalytic site [active] 1150475007166 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1150475007167 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1150475007168 YqzE-like protein; Region: YqzE; pfam14038 1150475007169 ComG operon protein 7; Region: ComGG; pfam14173 1150475007170 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1150475007171 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1150475007172 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1150475007173 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1150475007174 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1150475007175 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1150475007176 Type II/IV secretion system protein; Region: T2SE; pfam00437 1150475007177 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1150475007178 Walker A motif; other site 1150475007179 ATP binding site [chemical binding]; other site 1150475007180 Walker B motif; other site 1150475007181 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1150475007182 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1150475007183 Cl binding site [ion binding]; other site 1150475007184 oligomer interface [polypeptide binding]; other site 1150475007185 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1150475007186 Domain of unknown function DUF21; Region: DUF21; pfam01595 1150475007187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1150475007188 Transporter associated domain; Region: CorC_HlyC; smart01091 1150475007189 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1150475007190 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1150475007191 ArsC family; Region: ArsC; pfam03960 1150475007192 putative catalytic residues [active] 1150475007193 thiol/disulfide switch; other site 1150475007194 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1150475007195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1150475007196 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1150475007197 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1150475007198 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1150475007199 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1150475007200 putative active site [active] 1150475007201 Zn binding site [ion binding]; other site 1150475007202 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1150475007203 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1150475007204 nucleotide binding site [chemical binding]; other site 1150475007205 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1150475007206 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1150475007207 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1150475007208 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1150475007209 YceG-like family; Region: YceG; pfam02618 1150475007210 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1150475007211 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1150475007212 Walker A/P-loop; other site 1150475007213 ATP binding site [chemical binding]; other site 1150475007214 Q-loop/lid; other site 1150475007215 ABC transporter signature motif; other site 1150475007216 Walker B; other site 1150475007217 D-loop; other site 1150475007218 H-loop/switch region; other site 1150475007219 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1150475007220 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1150475007221 Walker A/P-loop; other site 1150475007222 ATP binding site [chemical binding]; other site 1150475007223 Q-loop/lid; other site 1150475007224 ABC transporter signature motif; other site 1150475007225 Walker B; other site 1150475007226 D-loop; other site 1150475007227 H-loop/switch region; other site 1150475007228 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1150475007229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475007230 dimer interface [polypeptide binding]; other site 1150475007231 conserved gate region; other site 1150475007232 ABC-ATPase subunit interface; other site 1150475007233 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1150475007234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475007235 dimer interface [polypeptide binding]; other site 1150475007236 conserved gate region; other site 1150475007237 putative PBP binding loops; other site 1150475007238 ABC-ATPase subunit interface; other site 1150475007239 PBP superfamily domain; Region: PBP_like_2; cl17296 1150475007240 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1150475007241 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1150475007242 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1150475007243 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1150475007244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475007245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475007246 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1150475007247 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1150475007248 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1150475007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1150475007250 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1150475007251 Lysin motif; Region: LysM; smart00257 1150475007252 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1150475007253 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1150475007254 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1150475007255 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1150475007256 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1150475007257 metal binding site 2 [ion binding]; metal-binding site 1150475007258 putative DNA binding helix; other site 1150475007259 metal binding site 1 [ion binding]; metal-binding site 1150475007260 dimer interface [polypeptide binding]; other site 1150475007261 structural Zn2+ binding site [ion binding]; other site 1150475007262 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1150475007263 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475007264 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1150475007265 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1150475007266 endonuclease IV; Provisional; Region: PRK01060 1150475007267 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1150475007268 AP (apurinic/apyrimidinic) site pocket; other site 1150475007269 DNA interaction; other site 1150475007270 Metal-binding active site; metal-binding site 1150475007271 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1150475007272 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1150475007273 ATP binding site [chemical binding]; other site 1150475007274 Mg++ binding site [ion binding]; other site 1150475007275 motif III; other site 1150475007276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475007277 nucleotide binding region [chemical binding]; other site 1150475007278 ATP-binding site [chemical binding]; other site 1150475007279 YqfQ-like protein; Region: YqfQ; pfam14181 1150475007280 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1150475007281 LytB protein; Region: LYTB; pfam02401 1150475007282 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1150475007283 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1150475007284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1150475007285 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1150475007286 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1150475007287 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1150475007288 Family of unknown function (DUF633); Region: DUF633; pfam04816 1150475007289 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1150475007290 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1150475007291 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1150475007292 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1150475007293 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1150475007294 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475007295 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1150475007296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475007297 DNA binding residues [nucleotide binding] 1150475007298 DNA primase; Validated; Region: dnaG; PRK05667 1150475007299 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1150475007300 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1150475007301 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1150475007302 active site 1150475007303 metal binding site [ion binding]; metal-binding site 1150475007304 interdomain interaction site; other site 1150475007305 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1150475007306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1150475007307 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1150475007308 HTH domain; Region: HTH_11; pfam08279 1150475007309 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1150475007310 FOG: CBS domain [General function prediction only]; Region: COG0517 1150475007311 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1150475007312 DALR anticodon binding domain; Region: DALR_1; pfam05746 1150475007313 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1150475007314 dimer interface [polypeptide binding]; other site 1150475007315 motif 1; other site 1150475007316 active site 1150475007317 motif 2; other site 1150475007318 motif 3; other site 1150475007319 Recombination protein O N terminal; Region: RecO_N; pfam11967 1150475007320 DNA repair protein RecO; Region: reco; TIGR00613 1150475007321 Recombination protein O C terminal; Region: RecO_C; pfam02565 1150475007322 YqzL-like protein; Region: YqzL; pfam14006 1150475007323 GTPase Era; Reviewed; Region: era; PRK00089 1150475007324 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1150475007325 G1 box; other site 1150475007326 GTP/Mg2+ binding site [chemical binding]; other site 1150475007327 Switch I region; other site 1150475007328 G2 box; other site 1150475007329 Switch II region; other site 1150475007330 G3 box; other site 1150475007331 G4 box; other site 1150475007332 G5 box; other site 1150475007333 KH domain; Region: KH_2; pfam07650 1150475007334 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1150475007335 active site 1150475007336 catalytic motif [active] 1150475007337 Zn binding site [ion binding]; other site 1150475007338 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1150475007339 metal-binding heat shock protein; Provisional; Region: PRK00016 1150475007340 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1150475007341 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1150475007342 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1150475007343 Zn2+ binding site [ion binding]; other site 1150475007344 Mg2+ binding site [ion binding]; other site 1150475007345 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1150475007346 PhoH-like protein; Region: PhoH; pfam02562 1150475007347 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1150475007348 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1150475007349 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1150475007350 hypothetical protein; Provisional; Region: PRK13665 1150475007351 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1150475007352 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1150475007353 dimer interface [polypeptide binding]; other site 1150475007354 active site residues [active] 1150475007355 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1150475007356 Yqey-like protein; Region: YqeY; pfam09424 1150475007357 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1150475007358 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1150475007359 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1150475007360 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1150475007361 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1150475007362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475007363 FeS/SAM binding site; other site 1150475007364 TRAM domain; Region: TRAM; cl01282 1150475007365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1150475007366 RNA methyltransferase, RsmE family; Region: TIGR00046 1150475007367 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1150475007368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475007369 S-adenosylmethionine binding site [chemical binding]; other site 1150475007370 chaperone protein DnaJ; Provisional; Region: PRK14280 1150475007371 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1150475007372 HSP70 interaction site [polypeptide binding]; other site 1150475007373 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1150475007374 substrate binding site [polypeptide binding]; other site 1150475007375 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1150475007376 Zn binding sites [ion binding]; other site 1150475007377 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1150475007378 dimer interface [polypeptide binding]; other site 1150475007379 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1150475007380 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1150475007381 nucleotide binding site [chemical binding]; other site 1150475007382 NEF interaction site [polypeptide binding]; other site 1150475007383 SBD interface [polypeptide binding]; other site 1150475007384 GrpE; Region: GrpE; pfam01025 1150475007385 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1150475007386 dimer interface [polypeptide binding]; other site 1150475007387 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1150475007388 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1150475007389 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1150475007390 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1150475007391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475007392 FeS/SAM binding site; other site 1150475007393 HemN C-terminal domain; Region: HemN_C; pfam06969 1150475007394 GTP-binding protein LepA; Provisional; Region: PRK05433 1150475007395 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1150475007396 G1 box; other site 1150475007397 putative GEF interaction site [polypeptide binding]; other site 1150475007398 GTP/Mg2+ binding site [chemical binding]; other site 1150475007399 Switch I region; other site 1150475007400 G2 box; other site 1150475007401 G3 box; other site 1150475007402 Switch II region; other site 1150475007403 G4 box; other site 1150475007404 G5 box; other site 1150475007405 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1150475007406 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1150475007407 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1150475007408 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1150475007409 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1150475007410 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1150475007411 germination protease; Provisional; Region: PRK02858 1150475007412 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1150475007413 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1150475007414 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1150475007415 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1150475007416 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1150475007417 Competence protein; Region: Competence; pfam03772 1150475007418 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1150475007419 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1150475007420 catalytic motif [active] 1150475007421 Zn binding site [ion binding]; other site 1150475007422 SLBB domain; Region: SLBB; pfam10531 1150475007423 comEA protein; Region: comE; TIGR01259 1150475007424 Helix-hairpin-helix motif; Region: HHH; pfam00633 1150475007425 late competence protein ComER; Validated; Region: PRK07680 1150475007426 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1150475007427 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1150475007428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475007429 S-adenosylmethionine binding site [chemical binding]; other site 1150475007430 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1150475007431 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1150475007432 Zn2+ binding site [ion binding]; other site 1150475007433 Mg2+ binding site [ion binding]; other site 1150475007434 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1150475007435 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1150475007436 active site 1150475007437 (T/H)XGH motif; other site 1150475007438 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1150475007439 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1150475007440 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1150475007441 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1150475007442 shikimate binding site; other site 1150475007443 NAD(P) binding site [chemical binding]; other site 1150475007444 GTPase YqeH; Provisional; Region: PRK13796 1150475007445 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1150475007446 GTP/Mg2+ binding site [chemical binding]; other site 1150475007447 G4 box; other site 1150475007448 G5 box; other site 1150475007449 G1 box; other site 1150475007450 Switch I region; other site 1150475007451 G2 box; other site 1150475007452 G3 box; other site 1150475007453 Switch II region; other site 1150475007454 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1150475007455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475007456 active site 1150475007457 motif I; other site 1150475007458 motif II; other site 1150475007459 Sporulation inhibitor A; Region: Sda; pfam08970 1150475007460 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1150475007461 active site 1150475007462 catalytic triad [active] 1150475007463 oxyanion hole [active] 1150475007464 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1150475007465 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1150475007466 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1150475007467 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1150475007468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475007469 Coenzyme A binding pocket [chemical binding]; other site 1150475007470 H+ Antiporter protein; Region: 2A0121; TIGR00900 1150475007471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475007472 putative substrate translocation pore; other site 1150475007473 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1150475007474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1150475007475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475007476 DNA binding residues [nucleotide binding] 1150475007477 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1150475007478 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1150475007479 aspartate racemase; Region: asp_race; TIGR00035 1150475007480 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1150475007481 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475007482 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475007483 active site 1150475007484 catalytic tetrad [active] 1150475007485 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1150475007486 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1150475007487 DNA binding residues [nucleotide binding] 1150475007488 putative dimer interface [polypeptide binding]; other site 1150475007489 Evidence 4 : Homologs of previously reported genes of unknown function 1150475007490 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1150475007491 Predicted transcriptional regulators [Transcription]; Region: COG1695 1150475007492 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1150475007493 LXG domain of WXG superfamily; Region: LXG; pfam04740 1150475007494 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1150475007495 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1150475007496 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1150475007497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475007498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475007499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475007500 dimerization interface [polypeptide binding]; other site 1150475007501 putative transporter; Provisional; Region: PRK11021 1150475007502 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1150475007503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475007504 HAMP domain; Region: HAMP; pfam00672 1150475007505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475007506 dimer interface [polypeptide binding]; other site 1150475007507 phosphorylation site [posttranslational modification] 1150475007508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475007509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475007510 active site 1150475007511 phosphorylation site [posttranslational modification] 1150475007512 intermolecular recognition site; other site 1150475007513 dimerization interface [polypeptide binding]; other site 1150475007514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475007515 DNA binding site [nucleotide binding] 1150475007516 Predicted membrane protein [Function unknown]; Region: COG2311 1150475007517 Protein of unknown function (DUF418); Region: DUF418; cl12135 1150475007518 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1150475007519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475007520 Coenzyme A binding pocket [chemical binding]; other site 1150475007521 hypothetical protein; Validated; Region: PRK06217 1150475007522 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1150475007523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475007524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475007525 putative substrate translocation pore; other site 1150475007526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475007527 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1150475007528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475007529 Coenzyme A binding pocket [chemical binding]; other site 1150475007530 DinB family; Region: DinB; pfam05163 1150475007531 DinB superfamily; Region: DinB_2; pfam12867 1150475007532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1150475007533 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1150475007534 active site 1150475007535 motif I; other site 1150475007536 motif II; other site 1150475007537 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1150475007538 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1150475007539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475007540 active site 1150475007541 motif I; other site 1150475007542 motif II; other site 1150475007543 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1150475007544 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1150475007545 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1150475007546 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1150475007547 putative active site [active] 1150475007548 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1150475007549 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1150475007550 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1150475007551 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1150475007552 active site 1150475007553 P-loop; other site 1150475007554 phosphorylation site [posttranslational modification] 1150475007555 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1150475007556 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1150475007557 active site 1150475007558 phosphorylation site [posttranslational modification] 1150475007559 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1150475007560 HTH domain; Region: HTH_11; cl17392 1150475007561 Mga helix-turn-helix domain; Region: Mga; pfam05043 1150475007562 PRD domain; Region: PRD; pfam00874 1150475007563 PRD domain; Region: PRD; pfam00874 1150475007564 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1150475007565 active site 1150475007566 P-loop; other site 1150475007567 phosphorylation site [posttranslational modification] 1150475007568 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1150475007569 active site 1150475007570 phosphorylation site [posttranslational modification] 1150475007571 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1150475007572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1150475007573 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1150475007574 putative deacylase active site [active] 1150475007575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475007576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475007577 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1150475007578 putative dimerization interface [polypeptide binding]; other site 1150475007579 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475007580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475007581 putative substrate translocation pore; other site 1150475007582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1150475007583 Cytochrome P450; Region: p450; pfam00067 1150475007584 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1150475007585 Flavodoxin; Region: Flavodoxin_1; pfam00258 1150475007586 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1150475007587 FAD binding pocket [chemical binding]; other site 1150475007588 FAD binding motif [chemical binding]; other site 1150475007589 catalytic residues [active] 1150475007590 NAD binding pocket [chemical binding]; other site 1150475007591 phosphate binding motif [ion binding]; other site 1150475007592 beta-alpha-beta structure motif; other site 1150475007593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475007594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475007595 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1150475007596 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1150475007597 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1150475007598 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1150475007599 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1150475007600 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1150475007601 catalytic loop [active] 1150475007602 iron binding site [ion binding]; other site 1150475007603 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1150475007604 4Fe-4S binding domain; Region: Fer4; pfam00037 1150475007605 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1150475007606 [4Fe-4S] binding site [ion binding]; other site 1150475007607 molybdopterin cofactor binding site; other site 1150475007608 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1150475007609 molybdopterin cofactor binding site; other site 1150475007610 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1150475007611 YrhC-like protein; Region: YrhC; pfam14143 1150475007612 cystathionine beta-lyase; Provisional; Region: PRK07671 1150475007613 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1150475007614 homodimer interface [polypeptide binding]; other site 1150475007615 substrate-cofactor binding pocket; other site 1150475007616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475007617 catalytic residue [active] 1150475007618 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1150475007619 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1150475007620 dimer interface [polypeptide binding]; other site 1150475007621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475007622 catalytic residue [active] 1150475007623 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1150475007624 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1150475007625 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1150475007626 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1150475007627 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1150475007628 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1150475007629 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1150475007630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1150475007631 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1150475007632 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1150475007633 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1150475007634 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1150475007635 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1150475007636 ATP-binding site [chemical binding]; other site 1150475007637 Sugar specificity; other site 1150475007638 Pyrimidine base specificity; other site 1150475007639 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1150475007640 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1150475007641 Peptidase family U32; Region: Peptidase_U32; pfam01136 1150475007642 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1150475007643 Peptidase family U32; Region: Peptidase_U32; pfam01136 1150475007644 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1150475007645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475007646 S-adenosylmethionine binding site [chemical binding]; other site 1150475007647 conserved hypothetical protein, YceG family; Region: TIGR00247 1150475007648 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1150475007649 dimerization interface [polypeptide binding]; other site 1150475007650 hypothetical protein; Provisional; Region: PRK13678 1150475007651 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1150475007652 hypothetical protein; Provisional; Region: PRK05473 1150475007653 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1150475007654 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1150475007655 motif 1; other site 1150475007656 active site 1150475007657 motif 2; other site 1150475007658 motif 3; other site 1150475007659 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1150475007660 DHHA1 domain; Region: DHHA1; pfam02272 1150475007661 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1150475007662 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1150475007663 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1150475007664 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1150475007665 Walker A/P-loop; other site 1150475007666 ATP binding site [chemical binding]; other site 1150475007667 Q-loop/lid; other site 1150475007668 ABC transporter signature motif; other site 1150475007669 Walker B; other site 1150475007670 D-loop; other site 1150475007671 H-loop/switch region; other site 1150475007672 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1150475007673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1150475007674 substrate binding pocket [chemical binding]; other site 1150475007675 membrane-bound complex binding site; other site 1150475007676 hinge residues; other site 1150475007677 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1150475007678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475007679 dimer interface [polypeptide binding]; other site 1150475007680 conserved gate region; other site 1150475007681 putative PBP binding loops; other site 1150475007682 ABC-ATPase subunit interface; other site 1150475007683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475007684 dimer interface [polypeptide binding]; other site 1150475007685 conserved gate region; other site 1150475007686 putative PBP binding loops; other site 1150475007687 ABC-ATPase subunit interface; other site 1150475007688 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1150475007689 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1150475007690 AAA domain; Region: AAA_30; pfam13604 1150475007691 Family description; Region: UvrD_C_2; pfam13538 1150475007692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475007693 binding surface 1150475007694 TPR repeat; Region: TPR_11; pfam13414 1150475007695 TPR motif; other site 1150475007696 TPR repeat; Region: TPR_11; pfam13414 1150475007697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475007698 binding surface 1150475007699 TPR motif; other site 1150475007700 TPR repeat; Region: TPR_11; pfam13414 1150475007701 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1150475007702 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1150475007703 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1150475007704 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1150475007705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1150475007706 catalytic residue [active] 1150475007707 Predicted transcriptional regulator [Transcription]; Region: COG1959 1150475007708 Transcriptional regulator; Region: Rrf2; pfam02082 1150475007709 recombination factor protein RarA; Reviewed; Region: PRK13342 1150475007710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475007711 Walker A motif; other site 1150475007712 ATP binding site [chemical binding]; other site 1150475007713 Walker B motif; other site 1150475007714 arginine finger; other site 1150475007715 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1150475007716 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1150475007717 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1150475007718 putative ATP binding site [chemical binding]; other site 1150475007719 putative substrate interface [chemical binding]; other site 1150475007720 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1150475007721 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1150475007722 dimer interface [polypeptide binding]; other site 1150475007723 anticodon binding site; other site 1150475007724 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1150475007725 homodimer interface [polypeptide binding]; other site 1150475007726 motif 1; other site 1150475007727 active site 1150475007728 motif 2; other site 1150475007729 GAD domain; Region: GAD; pfam02938 1150475007730 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1150475007731 active site 1150475007732 motif 3; other site 1150475007733 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1150475007734 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1150475007735 dimer interface [polypeptide binding]; other site 1150475007736 motif 1; other site 1150475007737 active site 1150475007738 motif 2; other site 1150475007739 motif 3; other site 1150475007740 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1150475007741 anticodon binding site; other site 1150475007742 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1150475007743 Bacterial SH3 domain; Region: SH3_3; pfam08239 1150475007744 Bacterial SH3 domain; Region: SH3_3; pfam08239 1150475007745 Bacterial SH3 domain; Region: SH3_3; pfam08239 1150475007746 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1150475007747 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1150475007748 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1150475007749 active site 1150475007750 metal binding site [ion binding]; metal-binding site 1150475007751 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1150475007752 putative active site [active] 1150475007753 dimerization interface [polypeptide binding]; other site 1150475007754 putative tRNAtyr binding site [nucleotide binding]; other site 1150475007755 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1150475007756 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1150475007757 Zn2+ binding site [ion binding]; other site 1150475007758 Mg2+ binding site [ion binding]; other site 1150475007759 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1150475007760 synthetase active site [active] 1150475007761 NTP binding site [chemical binding]; other site 1150475007762 metal binding site [ion binding]; metal-binding site 1150475007763 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1150475007764 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1150475007765 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475007766 active site 1150475007767 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1150475007768 DHH family; Region: DHH; pfam01368 1150475007769 DHHA1 domain; Region: DHHA1; pfam02272 1150475007770 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1150475007771 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1150475007772 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1150475007773 TrkA-C domain; Region: TrkA_C; pfam02080 1150475007774 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1150475007775 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1150475007776 Protein export membrane protein; Region: SecD_SecF; pfam02355 1150475007777 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1150475007778 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1150475007779 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1150475007780 Predicted membrane protein [Function unknown]; Region: COG2323 1150475007781 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1150475007782 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1150475007783 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1150475007784 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1150475007785 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1150475007786 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1150475007787 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1150475007788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475007789 Walker A motif; other site 1150475007790 ATP binding site [chemical binding]; other site 1150475007791 Walker B motif; other site 1150475007792 arginine finger; other site 1150475007793 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1150475007794 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1150475007795 RuvA N terminal domain; Region: RuvA_N; pfam01330 1150475007796 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1150475007797 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1150475007798 BofC C-terminal domain; Region: BofC_C; pfam08955 1150475007799 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1150475007800 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1150475007801 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475007802 quinolinate synthetase; Provisional; Region: PRK09375 1150475007803 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1150475007804 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1150475007805 dimerization interface [polypeptide binding]; other site 1150475007806 active site 1150475007807 L-aspartate oxidase; Provisional; Region: PRK08071 1150475007808 L-aspartate oxidase; Provisional; Region: PRK06175 1150475007809 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1150475007810 cysteine desulfurase; Provisional; Region: PRK02948 1150475007811 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1150475007812 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1150475007813 catalytic residue [active] 1150475007814 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1150475007815 HTH domain; Region: HTH_11; pfam08279 1150475007816 3H domain; Region: 3H; pfam02829 1150475007817 prephenate dehydratase; Provisional; Region: PRK11898 1150475007818 Prephenate dehydratase; Region: PDT; pfam00800 1150475007819 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1150475007820 putative L-Phe binding site [chemical binding]; other site 1150475007821 hypothetical protein; Provisional; Region: PRK04435 1150475007822 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1150475007823 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1150475007824 GTP1/OBG; Region: GTP1_OBG; pfam01018 1150475007825 Obg GTPase; Region: Obg; cd01898 1150475007826 G1 box; other site 1150475007827 GTP/Mg2+ binding site [chemical binding]; other site 1150475007828 Switch I region; other site 1150475007829 G2 box; other site 1150475007830 G3 box; other site 1150475007831 Switch II region; other site 1150475007832 G4 box; other site 1150475007833 G5 box; other site 1150475007834 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1150475007835 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1150475007836 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1150475007837 hypothetical protein; Provisional; Region: PRK14553 1150475007838 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1150475007839 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1150475007840 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1150475007841 Peptidase family M50; Region: Peptidase_M50; pfam02163 1150475007842 active site 1150475007843 putative substrate binding region [chemical binding]; other site 1150475007844 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1150475007845 Peptidase family M23; Region: Peptidase_M23; pfam01551 1150475007846 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1150475007847 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1150475007848 Switch I; other site 1150475007849 Switch II; other site 1150475007850 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1150475007851 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1150475007852 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1150475007853 rod shape-determining protein MreC; Region: mreC; TIGR00219 1150475007854 rod shape-determining protein MreC; Region: MreC; pfam04085 1150475007855 rod shape-determining protein MreB; Provisional; Region: PRK13927 1150475007856 MreB and similar proteins; Region: MreB_like; cd10225 1150475007857 nucleotide binding site [chemical binding]; other site 1150475007858 Mg binding site [ion binding]; other site 1150475007859 putative protofilament interaction site [polypeptide binding]; other site 1150475007860 RodZ interaction site [polypeptide binding]; other site 1150475007861 hypothetical protein; Reviewed; Region: PRK00024 1150475007862 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1150475007863 MPN+ (JAMM) motif; other site 1150475007864 Zinc-binding site [ion binding]; other site 1150475007865 Maf-like protein; Region: Maf; pfam02545 1150475007866 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1150475007867 active site 1150475007868 dimer interface [polypeptide binding]; other site 1150475007869 Sporulation related domain; Region: SPOR; pfam05036 1150475007870 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1150475007871 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1150475007872 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1150475007873 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1150475007874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1150475007875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1150475007876 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1150475007877 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1150475007878 active site 1150475007879 HIGH motif; other site 1150475007880 nucleotide binding site [chemical binding]; other site 1150475007881 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1150475007882 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1150475007883 active site 1150475007884 KMSKS motif; other site 1150475007885 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1150475007886 tRNA binding surface [nucleotide binding]; other site 1150475007887 anticodon binding site; other site 1150475007888 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1150475007889 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1150475007890 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1150475007891 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1150475007892 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1150475007893 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1150475007894 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1150475007895 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475007896 inhibitor-cofactor binding pocket; inhibition site 1150475007897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475007898 catalytic residue [active] 1150475007899 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1150475007900 dimer interface [polypeptide binding]; other site 1150475007901 active site 1150475007902 Schiff base residues; other site 1150475007903 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1150475007904 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1150475007905 active site 1150475007906 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1150475007907 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1150475007908 domain interfaces; other site 1150475007909 active site 1150475007910 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1150475007911 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1150475007912 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1150475007913 tRNA; other site 1150475007914 putative tRNA binding site [nucleotide binding]; other site 1150475007915 putative NADP binding site [chemical binding]; other site 1150475007916 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1150475007917 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1150475007918 G1 box; other site 1150475007919 GTP/Mg2+ binding site [chemical binding]; other site 1150475007920 Switch I region; other site 1150475007921 G2 box; other site 1150475007922 G3 box; other site 1150475007923 Switch II region; other site 1150475007924 G4 box; other site 1150475007925 G5 box; other site 1150475007926 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1150475007927 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1150475007928 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1150475007929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475007930 Walker A motif; other site 1150475007931 ATP binding site [chemical binding]; other site 1150475007932 Walker B motif; other site 1150475007933 arginine finger; other site 1150475007934 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1150475007935 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1150475007936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475007937 Walker A motif; other site 1150475007938 ATP binding site [chemical binding]; other site 1150475007939 Walker B motif; other site 1150475007940 arginine finger; other site 1150475007941 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1150475007942 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1150475007943 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1150475007944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475007945 Walker A motif; other site 1150475007946 ATP binding site [chemical binding]; other site 1150475007947 Walker B motif; other site 1150475007948 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1150475007949 trigger factor; Provisional; Region: tig; PRK01490 1150475007950 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1150475007951 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1150475007952 TPR repeat; Region: TPR_11; pfam13414 1150475007953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475007954 binding surface 1150475007955 TPR motif; other site 1150475007956 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1150475007957 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1150475007958 substrate binding site [chemical binding]; other site 1150475007959 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1150475007960 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1150475007961 substrate binding site [chemical binding]; other site 1150475007962 ligand binding site [chemical binding]; other site 1150475007963 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1150475007964 tartrate dehydrogenase; Region: TTC; TIGR02089 1150475007965 2-isopropylmalate synthase; Validated; Region: PRK00915 1150475007966 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1150475007967 active site 1150475007968 catalytic residues [active] 1150475007969 metal binding site [ion binding]; metal-binding site 1150475007970 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1150475007971 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1150475007972 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1150475007973 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1150475007974 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1150475007975 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1150475007976 putative valine binding site [chemical binding]; other site 1150475007977 dimer interface [polypeptide binding]; other site 1150475007978 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1150475007979 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1150475007980 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1150475007981 PYR/PP interface [polypeptide binding]; other site 1150475007982 dimer interface [polypeptide binding]; other site 1150475007983 TPP binding site [chemical binding]; other site 1150475007984 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1150475007985 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1150475007986 TPP-binding site [chemical binding]; other site 1150475007987 dimer interface [polypeptide binding]; other site 1150475007988 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1150475007989 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1150475007990 active site 1150475007991 metal binding site [ion binding]; metal-binding site 1150475007992 homotetramer interface [polypeptide binding]; other site 1150475007993 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1150475007994 active site 1150475007995 dimerization interface [polypeptide binding]; other site 1150475007996 ribonuclease PH; Reviewed; Region: rph; PRK00173 1150475007997 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1150475007998 hexamer interface [polypeptide binding]; other site 1150475007999 active site 1150475008000 Sporulation and spore germination; Region: Germane; pfam10646 1150475008001 Spore germination protein [General function prediction only]; Region: COG5401 1150475008002 Sporulation and spore germination; Region: Germane; pfam10646 1150475008003 glutamate racemase; Provisional; Region: PRK00865 1150475008004 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475008005 MarR family; Region: MarR; pfam01047 1150475008006 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475008007 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475008008 DNA binding residues [nucleotide binding] 1150475008009 dimerization interface [polypeptide binding]; other site 1150475008010 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1150475008011 active site 1150475008012 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1150475008013 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1150475008014 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1150475008015 L-aspartate oxidase; Provisional; Region: PRK06175 1150475008016 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1150475008017 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1150475008018 putative Iron-sulfur protein interface [polypeptide binding]; other site 1150475008019 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1150475008020 proximal heme binding site [chemical binding]; other site 1150475008021 distal heme binding site [chemical binding]; other site 1150475008022 putative dimer interface [polypeptide binding]; other site 1150475008023 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1150475008024 aspartate kinase; Reviewed; Region: PRK06635 1150475008025 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1150475008026 putative nucleotide binding site [chemical binding]; other site 1150475008027 putative catalytic residues [active] 1150475008028 putative Mg ion binding site [ion binding]; other site 1150475008029 putative aspartate binding site [chemical binding]; other site 1150475008030 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1150475008031 putative allosteric regulatory site; other site 1150475008032 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1150475008033 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1150475008034 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1150475008035 GIY-YIG motif/motif A; other site 1150475008036 active site 1150475008037 catalytic site [active] 1150475008038 putative DNA binding site [nucleotide binding]; other site 1150475008039 metal binding site [ion binding]; metal-binding site 1150475008040 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1150475008041 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1150475008042 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1150475008043 catalytic residues [active] 1150475008044 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1150475008045 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1150475008046 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1150475008047 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1150475008048 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1150475008049 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1150475008050 Ligand binding site [chemical binding]; other site 1150475008051 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1150475008052 enoyl-CoA hydratase; Provisional; Region: PRK07658 1150475008053 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1150475008054 substrate binding site [chemical binding]; other site 1150475008055 oxyanion hole (OAH) forming residues; other site 1150475008056 trimer interface [polypeptide binding]; other site 1150475008057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475008058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475008059 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1150475008060 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1150475008061 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1150475008062 acyl-activating enzyme (AAE) consensus motif; other site 1150475008063 putative AMP binding site [chemical binding]; other site 1150475008064 putative active site [active] 1150475008065 putative CoA binding site [chemical binding]; other site 1150475008066 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1150475008067 Predicted membrane protein [Function unknown]; Region: COG3766 1150475008068 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1150475008069 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1150475008070 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1150475008071 MutS domain III; Region: MutS_III; pfam05192 1150475008072 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1150475008073 Walker A/P-loop; other site 1150475008074 ATP binding site [chemical binding]; other site 1150475008075 Q-loop/lid; other site 1150475008076 ABC transporter signature motif; other site 1150475008077 Walker B; other site 1150475008078 D-loop; other site 1150475008079 H-loop/switch region; other site 1150475008080 Smr domain; Region: Smr; pfam01713 1150475008081 hypothetical protein; Provisional; Region: PRK08609 1150475008082 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1150475008083 active site 1150475008084 primer binding site [nucleotide binding]; other site 1150475008085 NTP binding site [chemical binding]; other site 1150475008086 metal binding triad [ion binding]; metal-binding site 1150475008087 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1150475008088 active site 1150475008089 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1150475008090 Colicin V production protein; Region: Colicin_V; pfam02674 1150475008091 cell division protein ZapA; Provisional; Region: PRK14126 1150475008092 ribonuclease HIII; Provisional; Region: PRK00996 1150475008093 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1150475008094 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1150475008095 RNA/DNA hybrid binding site [nucleotide binding]; other site 1150475008096 active site 1150475008097 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1150475008098 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1150475008099 putative tRNA-binding site [nucleotide binding]; other site 1150475008100 B3/4 domain; Region: B3_4; pfam03483 1150475008101 tRNA synthetase B5 domain; Region: B5; smart00874 1150475008102 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1150475008103 dimer interface [polypeptide binding]; other site 1150475008104 motif 1; other site 1150475008105 motif 3; other site 1150475008106 motif 2; other site 1150475008107 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1150475008108 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1150475008109 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1150475008110 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1150475008111 dimer interface [polypeptide binding]; other site 1150475008112 motif 1; other site 1150475008113 active site 1150475008114 motif 2; other site 1150475008115 motif 3; other site 1150475008116 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1150475008117 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1150475008118 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1150475008119 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1150475008120 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1150475008121 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1150475008122 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1150475008123 FAD binding domain; Region: FAD_binding_4; pfam01565 1150475008124 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1150475008125 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1150475008126 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1150475008127 Cysteine-rich domain; Region: CCG; pfam02754 1150475008128 Cysteine-rich domain; Region: CCG; pfam02754 1150475008129 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1150475008130 Carbon starvation protein CstA; Region: CstA; pfam02554 1150475008131 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1150475008132 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1150475008133 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1150475008134 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1150475008135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475008136 putative PBP binding loops; other site 1150475008137 dimer interface [polypeptide binding]; other site 1150475008138 ABC-ATPase subunit interface; other site 1150475008139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475008140 dimer interface [polypeptide binding]; other site 1150475008141 conserved gate region; other site 1150475008142 putative PBP binding loops; other site 1150475008143 ABC-ATPase subunit interface; other site 1150475008144 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1150475008145 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1150475008146 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1150475008147 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1150475008148 active site 1150475008149 metal binding site [ion binding]; metal-binding site 1150475008150 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1150475008151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475008152 active site 1150475008153 motif I; other site 1150475008154 motif II; other site 1150475008155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475008156 motif II; other site 1150475008157 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1150475008158 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1150475008159 intersubunit interface [polypeptide binding]; other site 1150475008160 active site 1150475008161 Zn2+ binding site [ion binding]; other site 1150475008162 ribulokinase; Provisional; Region: PRK04123 1150475008163 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1150475008164 N- and C-terminal domain interface [polypeptide binding]; other site 1150475008165 active site 1150475008166 MgATP binding site [chemical binding]; other site 1150475008167 catalytic site [active] 1150475008168 metal binding site [ion binding]; metal-binding site 1150475008169 carbohydrate binding site [chemical binding]; other site 1150475008170 homodimer interface [polypeptide binding]; other site 1150475008171 L-arabinose isomerase; Provisional; Region: PRK02929 1150475008172 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1150475008173 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1150475008174 trimer interface [polypeptide binding]; other site 1150475008175 putative substrate binding site [chemical binding]; other site 1150475008176 putative metal binding site [ion binding]; other site 1150475008177 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1150475008178 substrate binding site [chemical binding]; other site 1150475008179 active site 1150475008180 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1150475008181 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1150475008182 oligomer interface [polypeptide binding]; other site 1150475008183 active site 1150475008184 metal binding site [ion binding]; metal-binding site 1150475008185 Predicted membrane protein [Function unknown]; Region: COG3326 1150475008186 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1150475008187 23S rRNA binding site [nucleotide binding]; other site 1150475008188 L21 binding site [polypeptide binding]; other site 1150475008189 L13 binding site [polypeptide binding]; other site 1150475008190 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1150475008191 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1150475008192 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1150475008193 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1150475008194 antiholin-like protein LrgB; Provisional; Region: PRK04288 1150475008195 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1150475008196 two-component response regulator; Provisional; Region: PRK14084 1150475008197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475008198 active site 1150475008199 phosphorylation site [posttranslational modification] 1150475008200 intermolecular recognition site; other site 1150475008201 dimerization interface [polypeptide binding]; other site 1150475008202 LytTr DNA-binding domain; Region: LytTR; smart00850 1150475008203 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1150475008204 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1150475008205 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1150475008206 Histidine kinase; Region: His_kinase; pfam06580 1150475008207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475008208 ATP binding site [chemical binding]; other site 1150475008209 Mg2+ binding site [ion binding]; other site 1150475008210 G-X-G motif; other site 1150475008211 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1150475008212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475008213 motif II; other site 1150475008214 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1150475008215 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1150475008216 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1150475008217 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1150475008218 active site 1150475008219 dimer interface [polypeptide binding]; other site 1150475008220 motif 1; other site 1150475008221 motif 2; other site 1150475008222 motif 3; other site 1150475008223 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1150475008224 anticodon binding site; other site 1150475008225 YtxC-like family; Region: YtxC; pfam08812 1150475008226 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1150475008227 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1150475008228 primosomal protein DnaI; Reviewed; Region: PRK08939 1150475008229 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1150475008230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475008231 Walker A motif; other site 1150475008232 ATP binding site [chemical binding]; other site 1150475008233 Walker B motif; other site 1150475008234 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1150475008235 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1150475008236 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1150475008237 ATP cone domain; Region: ATP-cone; pfam03477 1150475008238 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1150475008239 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1150475008240 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1150475008241 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1150475008242 Predicted transcriptional regulators [Transcription]; Region: COG1733 1150475008243 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1150475008244 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475008245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475008246 putative substrate translocation pore; other site 1150475008247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475008248 active site 1150475008249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475008250 catalytic tetrad [active] 1150475008251 dephospho-CoA kinase; Region: TIGR00152 1150475008252 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1150475008253 CoA-binding site [chemical binding]; other site 1150475008254 ATP-binding [chemical binding]; other site 1150475008255 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1150475008256 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1150475008257 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1150475008258 DNA binding site [nucleotide binding] 1150475008259 catalytic residue [active] 1150475008260 H2TH interface [polypeptide binding]; other site 1150475008261 putative catalytic residues [active] 1150475008262 turnover-facilitating residue; other site 1150475008263 intercalation triad [nucleotide binding]; other site 1150475008264 8OG recognition residue [nucleotide binding]; other site 1150475008265 putative reading head residues; other site 1150475008266 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1150475008267 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1150475008268 DNA polymerase I; Provisional; Region: PRK05755 1150475008269 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1150475008270 active site 1150475008271 metal binding site 1 [ion binding]; metal-binding site 1150475008272 putative 5' ssDNA interaction site; other site 1150475008273 metal binding site 3; metal-binding site 1150475008274 metal binding site 2 [ion binding]; metal-binding site 1150475008275 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1150475008276 putative DNA binding site [nucleotide binding]; other site 1150475008277 putative metal binding site [ion binding]; other site 1150475008278 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1150475008279 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1150475008280 active site 1150475008281 DNA binding site [nucleotide binding] 1150475008282 catalytic site [active] 1150475008283 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1150475008284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475008285 putative active site [active] 1150475008286 heme pocket [chemical binding]; other site 1150475008287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475008288 dimer interface [polypeptide binding]; other site 1150475008289 phosphorylation site [posttranslational modification] 1150475008290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475008291 ATP binding site [chemical binding]; other site 1150475008292 Mg2+ binding site [ion binding]; other site 1150475008293 G-X-G motif; other site 1150475008294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475008295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475008296 active site 1150475008297 phosphorylation site [posttranslational modification] 1150475008298 intermolecular recognition site; other site 1150475008299 dimerization interface [polypeptide binding]; other site 1150475008300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475008301 DNA binding site [nucleotide binding] 1150475008302 malate dehydrogenase; Reviewed; Region: PRK06223 1150475008303 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1150475008304 NAD(P) binding site [chemical binding]; other site 1150475008305 dimer interface [polypeptide binding]; other site 1150475008306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1150475008307 substrate binding site [chemical binding]; other site 1150475008308 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1150475008309 isocitrate dehydrogenase; Validated; Region: PRK07362 1150475008310 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1150475008311 dimer interface [polypeptide binding]; other site 1150475008312 Citrate synthase; Region: Citrate_synt; pfam00285 1150475008313 active site 1150475008314 citrylCoA binding site [chemical binding]; other site 1150475008315 oxalacetate/citrate binding site [chemical binding]; other site 1150475008316 coenzyme A binding site [chemical binding]; other site 1150475008317 catalytic triad [active] 1150475008318 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1150475008319 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1150475008320 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1150475008321 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1150475008322 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1150475008323 pyruvate kinase; Provisional; Region: PRK06354 1150475008324 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1150475008325 domain interfaces; other site 1150475008326 active site 1150475008327 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1150475008328 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1150475008329 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1150475008330 active site 1150475008331 ADP/pyrophosphate binding site [chemical binding]; other site 1150475008332 dimerization interface [polypeptide binding]; other site 1150475008333 allosteric effector site; other site 1150475008334 fructose-1,6-bisphosphate binding site; other site 1150475008335 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1150475008336 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1150475008337 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1150475008338 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1150475008339 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1150475008340 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1150475008341 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1150475008342 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1150475008343 putative NAD(P) binding site [chemical binding]; other site 1150475008344 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1150475008345 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1150475008346 active site 1150475008347 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1150475008348 generic binding surface I; other site 1150475008349 generic binding surface II; other site 1150475008350 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1150475008351 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1150475008352 DHH family; Region: DHH; pfam01368 1150475008353 DHHA1 domain; Region: DHHA1; pfam02272 1150475008354 YtpI-like protein; Region: YtpI; pfam14007 1150475008355 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1150475008356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475008357 DNA-binding site [nucleotide binding]; DNA binding site 1150475008358 DRTGG domain; Region: DRTGG; pfam07085 1150475008359 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1150475008360 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1150475008361 active site 2 [active] 1150475008362 active site 1 [active] 1150475008363 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1150475008364 metal-dependent hydrolase; Provisional; Region: PRK00685 1150475008365 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1150475008366 classical (c) SDRs; Region: SDR_c; cd05233 1150475008367 NAD(P) binding site [chemical binding]; other site 1150475008368 active site 1150475008369 argininosuccinate lyase; Provisional; Region: PRK00855 1150475008370 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1150475008371 active sites [active] 1150475008372 tetramer interface [polypeptide binding]; other site 1150475008373 argininosuccinate synthase; Provisional; Region: PRK13820 1150475008374 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1150475008375 ANP binding site [chemical binding]; other site 1150475008376 Substrate Binding Site II [chemical binding]; other site 1150475008377 Substrate Binding Site I [chemical binding]; other site 1150475008378 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1150475008379 MPT binding site; other site 1150475008380 trimer interface [polypeptide binding]; other site 1150475008381 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1150475008382 propionate/acetate kinase; Provisional; Region: PRK12379 1150475008383 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1150475008384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475008385 S-adenosylmethionine binding site [chemical binding]; other site 1150475008386 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1150475008387 dimer interface [polypeptide binding]; other site 1150475008388 catalytic triad [active] 1150475008389 peroxidatic and resolving cysteines [active] 1150475008390 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1150475008391 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1150475008392 RDD family; Region: RDD; pfam06271 1150475008393 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1150475008394 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1150475008395 tandem repeat interface [polypeptide binding]; other site 1150475008396 oligomer interface [polypeptide binding]; other site 1150475008397 active site residues [active] 1150475008398 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1150475008399 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1150475008400 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1150475008401 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1150475008402 active site 1150475008403 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1150475008404 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1150475008405 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1150475008406 active site 1150475008407 acyl-activating enzyme (AAE) consensus motif; other site 1150475008408 putative CoA binding site [chemical binding]; other site 1150475008409 AMP binding site [chemical binding]; other site 1150475008410 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1150475008411 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1150475008412 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1150475008413 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1150475008414 Ligand Binding Site [chemical binding]; other site 1150475008415 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1150475008416 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1150475008417 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1150475008418 catalytic residue [active] 1150475008419 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1150475008420 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1150475008421 TMPIT-like protein; Region: TMPIT; pfam07851 1150475008422 histidinol-phosphatase; Reviewed; Region: PRK08123 1150475008423 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1150475008424 active site 1150475008425 dimer interface [polypeptide binding]; other site 1150475008426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475008427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475008428 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1150475008429 GAF domain; Region: GAF_2; pfam13185 1150475008430 GAF domain; Region: GAF_3; pfam13492 1150475008431 GAF domain; Region: GAF_2; pfam13185 1150475008432 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1150475008433 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1150475008434 metal binding site [ion binding]; metal-binding site 1150475008435 active site 1150475008436 I-site; other site 1150475008437 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1150475008438 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1150475008439 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1150475008440 RNA binding surface [nucleotide binding]; other site 1150475008441 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1150475008442 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1150475008443 NAD(P) binding site [chemical binding]; other site 1150475008444 catalytic residues [active] 1150475008445 Evidence 4 : Homologs of previously reported genes of unknown function 1150475008446 Evidence 4 : Homologs of previously reported genes of unknown function 1150475008447 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1150475008448 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1150475008449 heme-binding site [chemical binding]; other site 1150475008450 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1150475008451 FAD binding pocket [chemical binding]; other site 1150475008452 FAD binding motif [chemical binding]; other site 1150475008453 phosphate binding motif [ion binding]; other site 1150475008454 beta-alpha-beta structure motif; other site 1150475008455 NAD binding pocket [chemical binding]; other site 1150475008456 Heme binding pocket [chemical binding]; other site 1150475008457 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1150475008458 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1150475008459 proposed catalytic triad [active] 1150475008460 conserved cys residue [active] 1150475008461 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1150475008462 active site 1150475008463 catalytic triad [active] 1150475008464 oxyanion hole [active] 1150475008465 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1150475008466 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1150475008467 Predicted transcriptional regulators [Transcription]; Region: COG1378 1150475008468 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1150475008469 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1150475008470 C-terminal domain interface [polypeptide binding]; other site 1150475008471 sugar binding site [chemical binding]; other site 1150475008472 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1150475008473 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1150475008474 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1150475008475 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1150475008476 active site 1150475008477 HIGH motif; other site 1150475008478 dimer interface [polypeptide binding]; other site 1150475008479 KMSKS motif; other site 1150475008480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1150475008481 RNA binding surface [nucleotide binding]; other site 1150475008482 acetyl-CoA synthetase; Provisional; Region: PRK04319 1150475008483 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1150475008484 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1150475008485 active site 1150475008486 acyl-activating enzyme (AAE) consensus motif; other site 1150475008487 putative CoA binding site [chemical binding]; other site 1150475008488 AMP binding site [chemical binding]; other site 1150475008489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475008490 Coenzyme A binding pocket [chemical binding]; other site 1150475008491 FOG: CBS domain [General function prediction only]; Region: COG0517 1150475008492 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1150475008493 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1150475008494 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1150475008495 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1150475008496 active site 1150475008497 Zn binding site [ion binding]; other site 1150475008498 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1150475008499 flagellar motor protein MotS; Reviewed; Region: PRK06925 1150475008500 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1150475008501 ligand binding site [chemical binding]; other site 1150475008502 flagellar motor protein MotP; Reviewed; Region: PRK06926 1150475008503 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1150475008504 catabolite control protein A; Region: ccpA; TIGR01481 1150475008505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475008506 DNA binding site [nucleotide binding] 1150475008507 domain linker motif; other site 1150475008508 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1150475008509 dimerization interface [polypeptide binding]; other site 1150475008510 effector binding site; other site 1150475008511 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1150475008512 Chorismate mutase type II; Region: CM_2; cl00693 1150475008513 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1150475008514 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1150475008515 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1150475008516 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1150475008517 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1150475008518 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1150475008519 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1150475008520 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1150475008521 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1150475008522 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1150475008523 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1150475008524 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1150475008525 putative tRNA-binding site [nucleotide binding]; other site 1150475008526 hypothetical protein; Provisional; Region: PRK13668 1150475008527 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1150475008528 catalytic residues [active] 1150475008529 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1150475008530 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1150475008531 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1150475008532 oligomer interface [polypeptide binding]; other site 1150475008533 active site 1150475008534 metal binding site [ion binding]; metal-binding site 1150475008535 Predicted small secreted protein [Function unknown]; Region: COG5584 1150475008536 malate dehydrogenase; Provisional; Region: PRK13529 1150475008537 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1150475008538 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1150475008539 NAD(P) binding site [chemical binding]; other site 1150475008540 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1150475008541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475008542 S-adenosylmethionine binding site [chemical binding]; other site 1150475008543 YtzH-like protein; Region: YtzH; pfam14165 1150475008544 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1150475008545 active site 1150475008546 ATP binding site [chemical binding]; other site 1150475008547 Phosphotransferase enzyme family; Region: APH; pfam01636 1150475008548 substrate binding site [chemical binding]; other site 1150475008549 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1150475008550 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1150475008551 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1150475008552 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1150475008553 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1150475008554 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1150475008555 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1150475008556 dimer interface [polypeptide binding]; other site 1150475008557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475008558 catalytic residue [active] 1150475008559 dipeptidase PepV; Reviewed; Region: PRK07318 1150475008560 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1150475008561 active site 1150475008562 metal binding site [ion binding]; metal-binding site 1150475008563 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1150475008564 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1150475008565 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1150475008566 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1150475008567 Walker A/P-loop; other site 1150475008568 ATP binding site [chemical binding]; other site 1150475008569 Q-loop/lid; other site 1150475008570 ABC transporter signature motif; other site 1150475008571 Walker B; other site 1150475008572 D-loop; other site 1150475008573 H-loop/switch region; other site 1150475008574 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1150475008575 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1150475008576 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1150475008577 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1150475008578 RNA binding surface [nucleotide binding]; other site 1150475008579 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1150475008580 active site 1150475008581 uracil binding [chemical binding]; other site 1150475008582 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1150475008583 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1150475008584 HI0933-like protein; Region: HI0933_like; pfam03486 1150475008585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1150475008586 BCCT family transporter; Region: BCCT; pfam02028 1150475008587 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1150475008588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475008589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475008590 DNA binding site [nucleotide binding] 1150475008591 domain linker motif; other site 1150475008592 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1150475008593 putative ligand binding site [chemical binding]; other site 1150475008594 putative dimerization interface [polypeptide binding]; other site 1150475008595 PBP superfamily domain; Region: PBP_like_2; cl17296 1150475008596 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1150475008597 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1150475008598 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1150475008599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475008600 dimer interface [polypeptide binding]; other site 1150475008601 conserved gate region; other site 1150475008602 putative PBP binding loops; other site 1150475008603 ABC-ATPase subunit interface; other site 1150475008604 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1150475008605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475008606 dimer interface [polypeptide binding]; other site 1150475008607 conserved gate region; other site 1150475008608 putative PBP binding loops; other site 1150475008609 ABC-ATPase subunit interface; other site 1150475008610 alpha-galactosidase; Provisional; Region: PRK15076 1150475008611 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1150475008612 NAD binding site [chemical binding]; other site 1150475008613 sugar binding site [chemical binding]; other site 1150475008614 divalent metal binding site [ion binding]; other site 1150475008615 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1150475008616 dimer interface [polypeptide binding]; other site 1150475008617 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1150475008618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475008619 Coenzyme A binding pocket [chemical binding]; other site 1150475008620 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1150475008621 active site residue [active] 1150475008622 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1150475008623 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1150475008624 HIGH motif; other site 1150475008625 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1150475008626 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1150475008627 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1150475008628 active site 1150475008629 KMSKS motif; other site 1150475008630 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1150475008631 tRNA binding surface [nucleotide binding]; other site 1150475008632 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1150475008633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475008634 PAS domain; Region: PAS_9; pfam13426 1150475008635 putative active site [active] 1150475008636 heme pocket [chemical binding]; other site 1150475008637 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1150475008638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475008639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475008640 putative substrate translocation pore; other site 1150475008641 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1150475008642 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1150475008643 FtsX-like permease family; Region: FtsX; pfam02687 1150475008644 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1150475008645 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1150475008646 Walker A/P-loop; other site 1150475008647 ATP binding site [chemical binding]; other site 1150475008648 Q-loop/lid; other site 1150475008649 ABC transporter signature motif; other site 1150475008650 Walker B; other site 1150475008651 D-loop; other site 1150475008652 H-loop/switch region; other site 1150475008653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475008654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1150475008655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475008656 ATP binding site [chemical binding]; other site 1150475008657 Mg2+ binding site [ion binding]; other site 1150475008658 G-X-G motif; other site 1150475008659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475008660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475008661 active site 1150475008662 phosphorylation site [posttranslational modification] 1150475008663 intermolecular recognition site; other site 1150475008664 dimerization interface [polypeptide binding]; other site 1150475008665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475008666 DNA binding site [nucleotide binding] 1150475008667 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1150475008668 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1150475008669 FtsX-like permease family; Region: FtsX; pfam02687 1150475008670 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1150475008671 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1150475008672 Walker A/P-loop; other site 1150475008673 ATP binding site [chemical binding]; other site 1150475008674 Q-loop/lid; other site 1150475008675 ABC transporter signature motif; other site 1150475008676 Walker B; other site 1150475008677 D-loop; other site 1150475008678 H-loop/switch region; other site 1150475008679 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1150475008680 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1150475008681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475008682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1150475008683 Walker A/P-loop; other site 1150475008684 ATP binding site [chemical binding]; other site 1150475008685 Q-loop/lid; other site 1150475008686 ABC transporter signature motif; other site 1150475008687 Walker B; other site 1150475008688 D-loop; other site 1150475008689 H-loop/switch region; other site 1150475008690 Predicted transcriptional regulators [Transcription]; Region: COG1725 1150475008691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475008692 DNA-binding site [nucleotide binding]; DNA binding site 1150475008693 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1150475008694 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1150475008695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475008696 S-adenosylmethionine binding site [chemical binding]; other site 1150475008697 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1150475008698 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1150475008699 active site 1150475008700 catalytic site [active] 1150475008701 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1150475008702 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1150475008703 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1150475008704 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1150475008705 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1150475008706 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1150475008707 trimer interface [polypeptide binding]; other site 1150475008708 putative metal binding site [ion binding]; other site 1150475008709 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1150475008710 Spore germination protein; Region: Spore_permease; cl17796 1150475008711 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1150475008712 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1150475008713 active site 1150475008714 dimer interface [polypeptide binding]; other site 1150475008715 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1150475008716 Ligand Binding Site [chemical binding]; other site 1150475008717 Molecular Tunnel; other site 1150475008718 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1150475008719 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1150475008720 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1150475008721 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1150475008722 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1150475008723 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1150475008724 active site 1150475008725 substrate-binding site [chemical binding]; other site 1150475008726 metal-binding site [ion binding] 1150475008727 ATP binding site [chemical binding]; other site 1150475008728 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1150475008729 Dienelactone hydrolase family; Region: DLH; pfam01738 1150475008730 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1150475008731 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1150475008732 NMT1-like family; Region: NMT1_2; pfam13379 1150475008733 substrate binding pocket [chemical binding]; other site 1150475008734 membrane-bound complex binding site; other site 1150475008735 hinge residues; other site 1150475008736 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1150475008737 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1150475008738 Walker A/P-loop; other site 1150475008739 ATP binding site [chemical binding]; other site 1150475008740 Q-loop/lid; other site 1150475008741 ABC transporter signature motif; other site 1150475008742 Walker B; other site 1150475008743 D-loop; other site 1150475008744 H-loop/switch region; other site 1150475008745 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1150475008746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475008747 dimer interface [polypeptide binding]; other site 1150475008748 conserved gate region; other site 1150475008749 putative PBP binding loops; other site 1150475008750 ABC-ATPase subunit interface; other site 1150475008751 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1150475008752 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1150475008753 nudix motif; other site 1150475008754 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1150475008755 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1150475008756 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1150475008757 dimerization interface [polypeptide binding]; other site 1150475008758 DPS ferroxidase diiron center [ion binding]; other site 1150475008759 ion pore; other site 1150475008760 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 1150475008761 YtkA-like; Region: YtkA; pfam13115 1150475008762 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1150475008763 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1150475008764 active site clefts [active] 1150475008765 zinc binding site [ion binding]; other site 1150475008766 dimer interface [polypeptide binding]; other site 1150475008767 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1150475008768 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1150475008769 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1150475008770 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1150475008771 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1150475008772 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1150475008773 active site 1150475008774 octamer interface [polypeptide binding]; other site 1150475008775 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1150475008776 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1150475008777 acyl-activating enzyme (AAE) consensus motif; other site 1150475008778 putative AMP binding site [chemical binding]; other site 1150475008779 putative active site [active] 1150475008780 putative CoA binding site [chemical binding]; other site 1150475008781 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1150475008782 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1150475008783 substrate binding site [chemical binding]; other site 1150475008784 oxyanion hole (OAH) forming residues; other site 1150475008785 trimer interface [polypeptide binding]; other site 1150475008786 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1150475008787 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1150475008788 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1150475008789 dimer interface [polypeptide binding]; other site 1150475008790 tetramer interface [polypeptide binding]; other site 1150475008791 PYR/PP interface [polypeptide binding]; other site 1150475008792 TPP binding site [chemical binding]; other site 1150475008793 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1150475008794 TPP-binding site; other site 1150475008795 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1150475008796 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1150475008797 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1150475008798 TspO/MBR family; Region: TspO_MBR; cl01379 1150475008799 Predicted membrane protein [Function unknown]; Region: COG3859 1150475008800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1150475008801 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1150475008802 DinB superfamily; Region: DinB_2; pfam12867 1150475008803 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1150475008804 MOSC domain; Region: MOSC; pfam03473 1150475008805 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1150475008806 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1150475008807 active site 1150475008808 NAD binding site [chemical binding]; other site 1150475008809 metal binding site [ion binding]; metal-binding site 1150475008810 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1150475008811 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1150475008812 tetramerization interface [polypeptide binding]; other site 1150475008813 NAD(P) binding site [chemical binding]; other site 1150475008814 catalytic residues [active] 1150475008815 Predicted transcriptional regulators [Transcription]; Region: COG1510 1150475008816 MarR family; Region: MarR_2; pfam12802 1150475008817 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1150475008818 TrkA-N domain; Region: TrkA_N; pfam02254 1150475008819 TrkA-C domain; Region: TrkA_C; pfam02080 1150475008820 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1150475008821 SH3-like domain; Region: SH3_8; pfam13457 1150475008822 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1150475008823 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1150475008824 heme-binding site [chemical binding]; other site 1150475008825 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1150475008826 FAD binding pocket [chemical binding]; other site 1150475008827 FAD binding motif [chemical binding]; other site 1150475008828 phosphate binding motif [ion binding]; other site 1150475008829 beta-alpha-beta structure motif; other site 1150475008830 NAD binding pocket [chemical binding]; other site 1150475008831 Heme binding pocket [chemical binding]; other site 1150475008832 Cupin; Region: Cupin_1; smart00835 1150475008833 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1150475008834 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1150475008835 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1150475008836 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1150475008837 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1150475008838 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1150475008839 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1150475008840 proposed catalytic triad [active] 1150475008841 conserved cys residue [active] 1150475008842 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1150475008843 Cache domain; Region: Cache_1; pfam02743 1150475008844 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1150475008845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475008846 dimerization interface [polypeptide binding]; other site 1150475008847 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475008848 dimer interface [polypeptide binding]; other site 1150475008849 putative CheW interface [polypeptide binding]; other site 1150475008850 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1150475008851 Cache domain; Region: Cache_1; pfam02743 1150475008852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475008853 dimerization interface [polypeptide binding]; other site 1150475008854 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475008855 dimer interface [polypeptide binding]; other site 1150475008856 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1150475008857 putative CheW interface [polypeptide binding]; other site 1150475008858 Tar ligand binding domain homologue; Region: TarH; pfam02203 1150475008859 Cache domain; Region: Cache_1; pfam02743 1150475008860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475008861 dimerization interface [polypeptide binding]; other site 1150475008862 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1150475008863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475008864 dimer interface [polypeptide binding]; other site 1150475008865 putative CheW interface [polypeptide binding]; other site 1150475008866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475008867 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1150475008868 Cache domain; Region: Cache_1; pfam02743 1150475008869 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475008870 dimerization interface [polypeptide binding]; other site 1150475008871 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1150475008872 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1150475008873 dimer interface [polypeptide binding]; other site 1150475008874 putative CheW interface [polypeptide binding]; other site 1150475008875 transglutaminase; Provisional; Region: tgl; PRK03187 1150475008876 Nitronate monooxygenase; Region: NMO; pfam03060 1150475008877 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1150475008878 FMN binding site [chemical binding]; other site 1150475008879 substrate binding site [chemical binding]; other site 1150475008880 putative catalytic residue [active] 1150475008881 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1150475008882 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1150475008883 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1150475008884 Ca binding site [ion binding]; other site 1150475008885 active site 1150475008886 catalytic site [active] 1150475008887 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1150475008888 Domain of unknown function DUF21; Region: DUF21; pfam01595 1150475008889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1150475008890 Transporter associated domain; Region: CorC_HlyC; smart01091 1150475008891 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1150475008892 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1150475008893 Ion channel; Region: Ion_trans_2; pfam07885 1150475008894 TrkA-N domain; Region: TrkA_N; pfam02254 1150475008895 YugN-like family; Region: YugN; pfam08868 1150475008896 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1150475008897 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1150475008898 active site 1150475008899 dimer interface [polypeptide binding]; other site 1150475008900 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1150475008901 dimer interface [polypeptide binding]; other site 1150475008902 active site 1150475008903 Predicted flavoprotein [General function prediction only]; Region: COG0431 1150475008904 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1150475008905 Isochorismatase family; Region: Isochorismatase; pfam00857 1150475008906 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1150475008907 catalytic triad [active] 1150475008908 dimer interface [polypeptide binding]; other site 1150475008909 conserved cis-peptide bond; other site 1150475008910 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1150475008911 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1150475008912 dimer interface [polypeptide binding]; other site 1150475008913 active site 1150475008914 metal binding site [ion binding]; metal-binding site 1150475008915 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1150475008916 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1150475008917 dimer interface [polypeptide binding]; other site 1150475008918 active site 1150475008919 metal binding site [ion binding]; metal-binding site 1150475008920 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1150475008921 general stress protein 13; Validated; Region: PRK08059 1150475008922 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1150475008923 RNA binding site [nucleotide binding]; other site 1150475008924 hypothetical protein; Validated; Region: PRK07682 1150475008925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475008926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475008927 homodimer interface [polypeptide binding]; other site 1150475008928 catalytic residue [active] 1150475008929 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1150475008930 AsnC family; Region: AsnC_trans_reg; pfam01037 1150475008931 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1150475008932 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1150475008933 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1150475008934 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1150475008935 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475008936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475008937 homodimer interface [polypeptide binding]; other site 1150475008938 catalytic residue [active] 1150475008939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475008940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475008941 dimer interface [polypeptide binding]; other site 1150475008942 phosphorylation site [posttranslational modification] 1150475008943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475008944 ATP binding site [chemical binding]; other site 1150475008945 Mg2+ binding site [ion binding]; other site 1150475008946 G-X-G motif; other site 1150475008947 Kinase associated protein B; Region: KapB; pfam08810 1150475008948 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1150475008949 active site 1150475008950 catalytic site [active] 1150475008951 substrate binding site [chemical binding]; other site 1150475008952 drug efflux system protein MdtG; Provisional; Region: PRK09874 1150475008953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475008954 putative substrate translocation pore; other site 1150475008955 Transglycosylase; Region: Transgly; pfam00912 1150475008956 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1150475008957 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1150475008958 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1150475008959 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1150475008960 PAS domain; Region: PAS; smart00091 1150475008961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475008962 ATP binding site [chemical binding]; other site 1150475008963 Mg2+ binding site [ion binding]; other site 1150475008964 G-X-G motif; other site 1150475008965 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1150475008966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475008967 active site 1150475008968 phosphorylation site [posttranslational modification] 1150475008969 intermolecular recognition site; other site 1150475008970 dimerization interface [polypeptide binding]; other site 1150475008971 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1150475008972 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1150475008973 ligand binding site [chemical binding]; other site 1150475008974 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1150475008975 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1150475008976 Walker A/P-loop; other site 1150475008977 ATP binding site [chemical binding]; other site 1150475008978 Q-loop/lid; other site 1150475008979 ABC transporter signature motif; other site 1150475008980 Walker B; other site 1150475008981 D-loop; other site 1150475008982 H-loop/switch region; other site 1150475008983 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1150475008984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1150475008985 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1150475008986 TM-ABC transporter signature motif; other site 1150475008987 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1150475008988 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1150475008989 TM-ABC transporter signature motif; other site 1150475008990 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1150475008991 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1150475008992 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1150475008993 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1150475008994 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1150475008995 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1150475008996 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1150475008997 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1150475008998 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1150475008999 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1150475009000 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1150475009001 CoenzymeA binding site [chemical binding]; other site 1150475009002 subunit interaction site [polypeptide binding]; other site 1150475009003 PHB binding site; other site 1150475009004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475009005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475009006 active site 1150475009007 phosphorylation site [posttranslational modification] 1150475009008 intermolecular recognition site; other site 1150475009009 dimerization interface [polypeptide binding]; other site 1150475009010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475009011 DNA binding residues [nucleotide binding] 1150475009012 dimerization interface [polypeptide binding]; other site 1150475009013 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1150475009014 protein binding site [polypeptide binding]; other site 1150475009015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1150475009016 Histidine kinase; Region: HisKA_3; pfam07730 1150475009017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475009018 ATP binding site [chemical binding]; other site 1150475009019 Mg2+ binding site [ion binding]; other site 1150475009020 G-X-G motif; other site 1150475009021 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1150475009022 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1150475009023 substrate binding pocket [chemical binding]; other site 1150475009024 substrate-Mg2+ binding site; other site 1150475009025 aspartate-rich region 1; other site 1150475009026 aspartate-rich region 2; other site 1150475009027 DegQ (SacQ) family; Region: DegQ; pfam08181 1150475009028 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1150475009029 EAL domain; Region: EAL; pfam00563 1150475009030 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1150475009031 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1150475009032 active site 1150475009033 Isochorismatase family; Region: Isochorismatase; pfam00857 1150475009034 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1150475009035 catalytic triad [active] 1150475009036 conserved cis-peptide bond; other site 1150475009037 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1150475009038 YueH-like protein; Region: YueH; pfam14166 1150475009039 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1150475009040 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1150475009041 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1150475009042 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1150475009043 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1150475009044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1150475009045 Zn2+ binding site [ion binding]; other site 1150475009046 Mg2+ binding site [ion binding]; other site 1150475009047 short chain dehydrogenase; Provisional; Region: PRK06924 1150475009048 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1150475009049 NADP binding site [chemical binding]; other site 1150475009050 homodimer interface [polypeptide binding]; other site 1150475009051 active site 1150475009052 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1150475009053 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1150475009054 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1150475009055 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1150475009056 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1150475009057 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1150475009058 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1150475009059 Domain of unknown function DUF87; Region: DUF87; pfam01935 1150475009060 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1150475009061 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1150475009062 Uncharacterized small protein [Function unknown]; Region: COG5417 1150475009063 Ubiquitin homologues; Region: UBQ; smart00213 1150475009064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1150475009065 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1150475009066 CodY GAF-like domain; Region: CodY; pfam06018 1150475009067 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1150475009068 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1150475009069 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1150475009070 hexamer interface [polypeptide binding]; other site 1150475009071 ligand binding site [chemical binding]; other site 1150475009072 putative active site [active] 1150475009073 NAD(P) binding site [chemical binding]; other site 1150475009074 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1150475009075 MbtH-like protein; Region: MbtH; cl01279 1150475009076 Condensation domain; Region: Condensation; pfam00668 1150475009077 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1150475009078 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1150475009079 acyl-activating enzyme (AAE) consensus motif; other site 1150475009080 AMP binding site [chemical binding]; other site 1150475009081 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475009082 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1150475009083 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475009084 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1150475009085 acyl-activating enzyme (AAE) consensus motif; other site 1150475009086 AMP binding site [chemical binding]; other site 1150475009087 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475009088 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1150475009089 hydrophobic substrate binding pocket; other site 1150475009090 Isochorismatase family; Region: Isochorismatase; pfam00857 1150475009091 active site 1150475009092 conserved cis-peptide bond; other site 1150475009093 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1150475009094 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1150475009095 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1150475009096 acyl-activating enzyme (AAE) consensus motif; other site 1150475009097 active site 1150475009098 AMP binding site [chemical binding]; other site 1150475009099 substrate binding site [chemical binding]; other site 1150475009100 isochorismate synthase DhbC; Validated; Region: PRK06923 1150475009101 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1150475009102 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1150475009103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475009104 NAD(P) binding site [chemical binding]; other site 1150475009105 active site 1150475009106 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1150475009107 Putative esterase; Region: Esterase; pfam00756 1150475009108 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1150475009109 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1150475009110 Moco binding site; other site 1150475009111 metal coordination site [ion binding]; other site 1150475009112 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1150475009113 Predicted permease [General function prediction only]; Region: COG2056 1150475009114 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1150475009115 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1150475009116 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1150475009117 interface (dimer of trimers) [polypeptide binding]; other site 1150475009118 Substrate-binding/catalytic site; other site 1150475009119 Zn-binding sites [ion binding]; other site 1150475009120 Divergent PAP2 family; Region: DUF212; pfam02681 1150475009121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1150475009122 Putative membrane protein; Region: YuiB; pfam14068 1150475009123 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1150475009124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475009125 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1150475009126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1150475009127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475009128 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1150475009129 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1150475009130 active site 1150475009131 Integral membrane protein DUF95; Region: DUF95; pfam01944 1150475009132 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1150475009133 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1150475009134 Walker A/P-loop; other site 1150475009135 ATP binding site [chemical binding]; other site 1150475009136 Q-loop/lid; other site 1150475009137 ABC transporter signature motif; other site 1150475009138 Walker B; other site 1150475009139 D-loop; other site 1150475009140 H-loop/switch region; other site 1150475009141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1150475009142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1150475009143 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1150475009144 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1150475009145 putative NAD(P) binding site [chemical binding]; other site 1150475009146 active site 1150475009147 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1150475009148 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1150475009149 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1150475009150 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1150475009151 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1150475009152 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1150475009153 Nucleoside recognition; Region: Gate; pfam07670 1150475009154 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1150475009155 hypothetical protein; Provisional; Region: PRK13669 1150475009156 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1150475009157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475009158 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1150475009159 NifU-like domain; Region: NifU; pfam01106 1150475009160 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1150475009161 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1150475009162 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1150475009163 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1150475009164 homoserine kinase; Provisional; Region: PRK01212 1150475009165 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1150475009166 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1150475009167 threonine synthase; Reviewed; Region: PRK06721 1150475009168 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1150475009169 homodimer interface [polypeptide binding]; other site 1150475009170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475009171 catalytic residue [active] 1150475009172 homoserine dehydrogenase; Provisional; Region: PRK06349 1150475009173 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1150475009174 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1150475009175 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1150475009176 spore coat protein YutH; Region: spore_yutH; TIGR02905 1150475009177 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1150475009178 tetramer interfaces [polypeptide binding]; other site 1150475009179 binuclear metal-binding site [ion binding]; other site 1150475009180 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1150475009181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475009182 active site 1150475009183 motif I; other site 1150475009184 motif II; other site 1150475009185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475009186 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1150475009187 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1150475009188 lipoyl synthase; Provisional; Region: PRK05481 1150475009189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475009190 FeS/SAM binding site; other site 1150475009191 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1150475009192 Peptidase family M23; Region: Peptidase_M23; pfam01551 1150475009193 sporulation protein YunB; Region: spo_yunB; TIGR02832 1150475009194 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1150475009195 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1150475009196 active site 1150475009197 metal binding site [ion binding]; metal-binding site 1150475009198 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1150475009199 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1150475009200 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1150475009201 allantoinase; Provisional; Region: PRK06189 1150475009202 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1150475009203 active site 1150475009204 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1150475009205 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1150475009206 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1150475009207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1150475009208 binding surface 1150475009209 TPR motif; other site 1150475009210 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475009211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475009212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475009213 binding surface 1150475009214 TPR motif; other site 1150475009215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475009216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475009217 putative substrate translocation pore; other site 1150475009218 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1150475009219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1150475009220 catalytic residue [active] 1150475009221 allantoate amidohydrolase; Reviewed; Region: PRK09290 1150475009222 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1150475009223 active site 1150475009224 metal binding site [ion binding]; metal-binding site 1150475009225 dimer interface [polypeptide binding]; other site 1150475009226 Endonuclease I; Region: Endonuclease_1; cl01003 1150475009227 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1150475009228 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1150475009229 Walker A/P-loop; other site 1150475009230 ATP binding site [chemical binding]; other site 1150475009231 Q-loop/lid; other site 1150475009232 ABC transporter signature motif; other site 1150475009233 Walker B; other site 1150475009234 D-loop; other site 1150475009235 H-loop/switch region; other site 1150475009236 TOBE domain; Region: TOBE_2; pfam08402 1150475009237 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1150475009238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475009239 DNA-binding site [nucleotide binding]; DNA binding site 1150475009240 UTRA domain; Region: UTRA; pfam07702 1150475009241 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1150475009242 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1150475009243 substrate binding site [chemical binding]; other site 1150475009244 ATP binding site [chemical binding]; other site 1150475009245 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1150475009246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009247 dimer interface [polypeptide binding]; other site 1150475009248 conserved gate region; other site 1150475009249 putative PBP binding loops; other site 1150475009250 ABC-ATPase subunit interface; other site 1150475009251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009252 dimer interface [polypeptide binding]; other site 1150475009253 conserved gate region; other site 1150475009254 putative PBP binding loops; other site 1150475009255 ABC-ATPase subunit interface; other site 1150475009256 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1150475009257 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1150475009258 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1150475009259 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1150475009260 putative active site [active] 1150475009261 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1150475009262 dimer interface [polypeptide binding]; other site 1150475009263 active site 1150475009264 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1150475009265 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1150475009266 DNA binding residues [nucleotide binding] 1150475009267 dimer interface [polypeptide binding]; other site 1150475009268 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1150475009269 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1150475009270 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1150475009271 GIY-YIG motif/motif A; other site 1150475009272 active site 1150475009273 catalytic site [active] 1150475009274 putative DNA binding site [nucleotide binding]; other site 1150475009275 metal binding site [ion binding]; metal-binding site 1150475009276 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1150475009277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475009278 S-adenosylmethionine binding site [chemical binding]; other site 1150475009279 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1150475009280 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1150475009281 chitosan binding site [chemical binding]; other site 1150475009282 catalytic residues [active] 1150475009283 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1150475009284 FeS assembly protein SufB; Region: sufB; TIGR01980 1150475009285 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1150475009286 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1150475009287 trimerization site [polypeptide binding]; other site 1150475009288 active site 1150475009289 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1150475009290 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1150475009291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1150475009292 catalytic residue [active] 1150475009293 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1150475009294 FeS assembly protein SufD; Region: sufD; TIGR01981 1150475009295 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1150475009296 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1150475009297 Walker A/P-loop; other site 1150475009298 ATP binding site [chemical binding]; other site 1150475009299 Q-loop/lid; other site 1150475009300 ABC transporter signature motif; other site 1150475009301 Walker B; other site 1150475009302 D-loop; other site 1150475009303 H-loop/switch region; other site 1150475009304 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1150475009305 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1150475009306 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1150475009307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009308 ABC-ATPase subunit interface; other site 1150475009309 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1150475009310 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1150475009311 Walker A/P-loop; other site 1150475009312 ATP binding site [chemical binding]; other site 1150475009313 Q-loop/lid; other site 1150475009314 ABC transporter signature motif; other site 1150475009315 Walker B; other site 1150475009316 D-loop; other site 1150475009317 H-loop/switch region; other site 1150475009318 NIL domain; Region: NIL; pfam09383 1150475009319 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1150475009320 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1150475009321 catalytic residues [active] 1150475009322 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1150475009323 putative active site [active] 1150475009324 putative metal binding site [ion binding]; other site 1150475009325 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1150475009326 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1150475009327 lipoyl attachment site [posttranslational modification]; other site 1150475009328 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1150475009329 ArsC family; Region: ArsC; pfam03960 1150475009330 putative ArsC-like catalytic residues; other site 1150475009331 putative TRX-like catalytic residues [active] 1150475009332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1150475009333 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1150475009334 active site 1150475009335 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1150475009336 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1150475009337 dimer interface [polypeptide binding]; other site 1150475009338 active site 1150475009339 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1150475009340 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1150475009341 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1150475009342 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1150475009343 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1150475009344 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1150475009345 substrate binding site [chemical binding]; other site 1150475009346 oxyanion hole (OAH) forming residues; other site 1150475009347 trimer interface [polypeptide binding]; other site 1150475009348 YuzL-like protein; Region: YuzL; pfam14115 1150475009349 Proline dehydrogenase; Region: Pro_dh; cl03282 1150475009350 Coat F domain; Region: Coat_F; pfam07875 1150475009351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475009352 MarR family; Region: MarR; pfam01047 1150475009353 MarR family; Region: MarR_2; cl17246 1150475009354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475009355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475009356 putative substrate translocation pore; other site 1150475009357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475009358 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475009359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475009360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475009361 dimerization interface [polypeptide binding]; other site 1150475009362 acetoacetate decarboxylase; Provisional; Region: PRK02265 1150475009363 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1150475009364 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1150475009365 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1150475009366 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1150475009367 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1150475009368 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1150475009369 Walker A/P-loop; other site 1150475009370 ATP binding site [chemical binding]; other site 1150475009371 Q-loop/lid; other site 1150475009372 ABC transporter signature motif; other site 1150475009373 Walker B; other site 1150475009374 D-loop; other site 1150475009375 H-loop/switch region; other site 1150475009376 YusW-like protein; Region: YusW; pfam14039 1150475009377 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1150475009378 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1150475009379 active site 1150475009380 Zn binding site [ion binding]; other site 1150475009381 short chain dehydrogenase; Provisional; Region: PRK06914 1150475009382 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1150475009383 NADP binding site [chemical binding]; other site 1150475009384 active site 1150475009385 steroid binding site; other site 1150475009386 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1150475009387 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1150475009388 dimerization interface [polypeptide binding]; other site 1150475009389 DPS ferroxidase diiron center [ion binding]; other site 1150475009390 ion pore; other site 1150475009391 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1150475009392 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1150475009393 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1150475009394 protein binding site [polypeptide binding]; other site 1150475009395 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475009396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475009397 active site 1150475009398 phosphorylation site [posttranslational modification] 1150475009399 intermolecular recognition site; other site 1150475009400 dimerization interface [polypeptide binding]; other site 1150475009401 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475009402 DNA binding site [nucleotide binding] 1150475009403 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475009404 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475009405 dimerization interface [polypeptide binding]; other site 1150475009406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475009407 dimer interface [polypeptide binding]; other site 1150475009408 phosphorylation site [posttranslational modification] 1150475009409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475009410 ATP binding site [chemical binding]; other site 1150475009411 Mg2+ binding site [ion binding]; other site 1150475009412 G-X-G motif; other site 1150475009413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475009414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475009415 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1150475009416 Class II fumarases; Region: Fumarase_classII; cd01362 1150475009417 active site 1150475009418 tetramer interface [polypeptide binding]; other site 1150475009419 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1150475009420 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1150475009421 Spore germination protein; Region: Spore_permease; pfam03845 1150475009422 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1150475009423 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1150475009424 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475009425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475009426 active site 1150475009427 phosphorylation site [posttranslational modification] 1150475009428 intermolecular recognition site; other site 1150475009429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475009430 DNA binding residues [nucleotide binding] 1150475009431 dimerization interface [polypeptide binding]; other site 1150475009432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1150475009433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475009434 dimerization interface [polypeptide binding]; other site 1150475009435 Histidine kinase; Region: HisKA_3; pfam07730 1150475009436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475009437 ATP binding site [chemical binding]; other site 1150475009438 Mg2+ binding site [ion binding]; other site 1150475009439 G-X-G motif; other site 1150475009440 Predicted membrane protein [Function unknown]; Region: COG4758 1150475009441 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1150475009442 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1150475009443 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1150475009444 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1150475009445 PspA/IM30 family; Region: PspA_IM30; pfam04012 1150475009446 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1150475009447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475009448 H+ Antiporter protein; Region: 2A0121; TIGR00900 1150475009449 putative substrate translocation pore; other site 1150475009450 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1150475009451 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1150475009452 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1150475009453 Walker A/P-loop; other site 1150475009454 ATP binding site [chemical binding]; other site 1150475009455 Q-loop/lid; other site 1150475009456 ABC transporter signature motif; other site 1150475009457 Walker B; other site 1150475009458 D-loop; other site 1150475009459 H-loop/switch region; other site 1150475009460 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1150475009461 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1150475009462 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475009463 ABC-ATPase subunit interface; other site 1150475009464 dimer interface [polypeptide binding]; other site 1150475009465 putative PBP binding regions; other site 1150475009466 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1150475009467 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1150475009468 putative binding site residues; other site 1150475009469 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1150475009470 classical (c) SDRs; Region: SDR_c; cd05233 1150475009471 NAD(P) binding site [chemical binding]; other site 1150475009472 active site 1150475009473 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1150475009474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475009475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475009476 dimer interface [polypeptide binding]; other site 1150475009477 phosphorylation site [posttranslational modification] 1150475009478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475009479 ATP binding site [chemical binding]; other site 1150475009480 Mg2+ binding site [ion binding]; other site 1150475009481 G-X-G motif; other site 1150475009482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475009483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475009484 active site 1150475009485 phosphorylation site [posttranslational modification] 1150475009486 intermolecular recognition site; other site 1150475009487 dimerization interface [polypeptide binding]; other site 1150475009488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475009489 DNA binding site [nucleotide binding] 1150475009490 hypothetical protein; Provisional; Region: PRK14082 1150475009491 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1150475009492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1150475009493 DNA binding residues [nucleotide binding] 1150475009494 YvrJ protein family; Region: YvrJ; pfam12841 1150475009495 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1150475009496 Cupin; Region: Cupin_1; smart00835 1150475009497 Cupin; Region: Cupin_1; smart00835 1150475009498 Regulatory protein YrvL; Region: YrvL; pfam14184 1150475009499 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1150475009500 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1150475009501 Walker A/P-loop; other site 1150475009502 ATP binding site [chemical binding]; other site 1150475009503 Q-loop/lid; other site 1150475009504 ABC transporter signature motif; other site 1150475009505 Walker B; other site 1150475009506 D-loop; other site 1150475009507 H-loop/switch region; other site 1150475009508 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1150475009509 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475009510 ABC-ATPase subunit interface; other site 1150475009511 dimer interface [polypeptide binding]; other site 1150475009512 putative PBP binding regions; other site 1150475009513 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1150475009514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475009515 ABC-ATPase subunit interface; other site 1150475009516 dimer interface [polypeptide binding]; other site 1150475009517 putative PBP binding regions; other site 1150475009518 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1150475009519 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1150475009520 putative ligand binding residues [chemical binding]; other site 1150475009521 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1150475009522 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1150475009523 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1150475009524 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 1150475009525 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1150475009526 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1150475009527 Sulfatase; Region: Sulfatase; pfam00884 1150475009528 DNA binding domain, excisionase family; Region: excise; TIGR01764 1150475009529 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1150475009530 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1150475009531 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1150475009532 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1150475009533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009534 dimer interface [polypeptide binding]; other site 1150475009535 conserved gate region; other site 1150475009536 putative PBP binding loops; other site 1150475009537 ABC-ATPase subunit interface; other site 1150475009538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475009539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475009540 active site 1150475009541 phosphorylation site [posttranslational modification] 1150475009542 intermolecular recognition site; other site 1150475009543 dimerization interface [polypeptide binding]; other site 1150475009544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475009545 DNA binding residues [nucleotide binding] 1150475009546 dimerization interface [polypeptide binding]; other site 1150475009547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1150475009548 Histidine kinase; Region: HisKA_3; pfam07730 1150475009549 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1150475009550 Mg2+ binding site [ion binding]; other site 1150475009551 G-X-G motif; other site 1150475009552 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475009553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475009554 Walker A/P-loop; other site 1150475009555 ATP binding site [chemical binding]; other site 1150475009556 Q-loop/lid; other site 1150475009557 ABC transporter signature motif; other site 1150475009558 Walker B; other site 1150475009559 D-loop; other site 1150475009560 H-loop/switch region; other site 1150475009561 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1150475009562 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1150475009563 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1150475009564 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1150475009565 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1150475009566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475009567 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475009568 active site 1150475009569 catalytic tetrad [active] 1150475009570 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1150475009571 sulfite reductase subunit beta; Provisional; Region: PRK13504 1150475009572 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1150475009573 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1150475009574 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1150475009575 Flavodoxin; Region: Flavodoxin_1; pfam00258 1150475009576 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1150475009577 FAD binding pocket [chemical binding]; other site 1150475009578 FAD binding motif [chemical binding]; other site 1150475009579 catalytic residues [active] 1150475009580 NAD binding pocket [chemical binding]; other site 1150475009581 phosphate binding motif [ion binding]; other site 1150475009582 beta-alpha-beta structure motif; other site 1150475009583 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1150475009584 Family description; Region: UvrD_C_2; pfam13538 1150475009585 Predicted membrane protein [Function unknown]; Region: COG2860 1150475009586 UPF0126 domain; Region: UPF0126; pfam03458 1150475009587 UPF0126 domain; Region: UPF0126; pfam03458 1150475009588 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 1150475009589 active site 1150475009590 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1150475009591 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1150475009592 Thioredoxin; Region: Thioredoxin_4; pfam13462 1150475009593 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1150475009594 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1150475009595 metal-binding site [ion binding] 1150475009596 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1150475009597 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1150475009598 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1150475009599 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1150475009600 metal-binding site [ion binding] 1150475009601 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1150475009602 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1150475009603 metal-binding site [ion binding] 1150475009604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1150475009605 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1150475009606 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1150475009607 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1150475009608 metal-binding site [ion binding] 1150475009609 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1150475009610 putative homodimer interface [polypeptide binding]; other site 1150475009611 putative homotetramer interface [polypeptide binding]; other site 1150475009612 putative allosteric switch controlling residues; other site 1150475009613 putative metal binding site [ion binding]; other site 1150475009614 putative homodimer-homodimer interface [polypeptide binding]; other site 1150475009615 putative oxidoreductase; Provisional; Region: PRK11579 1150475009616 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1150475009617 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1150475009618 azoreductase; Reviewed; Region: PRK00170 1150475009619 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1150475009620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475009621 salt bridge; other site 1150475009622 non-specific DNA binding site [nucleotide binding]; other site 1150475009623 sequence-specific DNA binding site [nucleotide binding]; other site 1150475009624 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475009625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475009626 putative substrate translocation pore; other site 1150475009627 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1150475009628 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1150475009629 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1150475009630 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1150475009631 active site 1150475009632 non-prolyl cis peptide bond; other site 1150475009633 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1150475009634 catalytic residues [active] 1150475009635 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1150475009636 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1150475009637 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1150475009638 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1150475009639 Walker A/P-loop; other site 1150475009640 ATP binding site [chemical binding]; other site 1150475009641 Q-loop/lid; other site 1150475009642 ABC transporter signature motif; other site 1150475009643 Walker B; other site 1150475009644 D-loop; other site 1150475009645 H-loop/switch region; other site 1150475009646 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1150475009647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009648 dimer interface [polypeptide binding]; other site 1150475009649 conserved gate region; other site 1150475009650 putative PBP binding loops; other site 1150475009651 ABC-ATPase subunit interface; other site 1150475009652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009653 dimer interface [polypeptide binding]; other site 1150475009654 conserved gate region; other site 1150475009655 putative PBP binding loops; other site 1150475009656 ABC-ATPase subunit interface; other site 1150475009657 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1150475009658 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1150475009659 substrate binding pocket [chemical binding]; other site 1150475009660 membrane-bound complex binding site; other site 1150475009661 hinge residues; other site 1150475009662 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1150475009663 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1150475009664 substrate binding pocket [chemical binding]; other site 1150475009665 membrane-bound complex binding site; other site 1150475009666 hinge residues; other site 1150475009667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1150475009668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475009669 Coenzyme A binding pocket [chemical binding]; other site 1150475009670 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1150475009671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475009672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475009673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475009674 dimerization interface [polypeptide binding]; other site 1150475009675 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1150475009676 classical (c) SDRs; Region: SDR_c; cd05233 1150475009677 NAD(P) binding site [chemical binding]; other site 1150475009678 active site 1150475009679 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1150475009680 RNAase interaction site [polypeptide binding]; other site 1150475009681 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1150475009682 SmpB-tmRNA interface; other site 1150475009683 ribonuclease R; Region: RNase_R; TIGR02063 1150475009684 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1150475009685 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1150475009686 RNB domain; Region: RNB; pfam00773 1150475009687 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1150475009688 RNA binding site [nucleotide binding]; other site 1150475009689 Esterase/lipase [General function prediction only]; Region: COG1647 1150475009690 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1150475009691 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1150475009692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475009693 salt bridge; other site 1150475009694 non-specific DNA binding site [nucleotide binding]; other site 1150475009695 sequence-specific DNA binding site [nucleotide binding]; other site 1150475009696 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1150475009697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475009698 non-specific DNA binding site [nucleotide binding]; other site 1150475009699 salt bridge; other site 1150475009700 sequence-specific DNA binding site [nucleotide binding]; other site 1150475009701 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1150475009702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475009703 non-specific DNA binding site [nucleotide binding]; other site 1150475009704 salt bridge; other site 1150475009705 sequence-specific DNA binding site [nucleotide binding]; other site 1150475009706 Predicted transcriptional regulators [Transcription]; Region: COG1733 1150475009707 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1150475009708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475009709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475009710 dimer interface [polypeptide binding]; other site 1150475009711 phosphorylation site [posttranslational modification] 1150475009712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475009713 ATP binding site [chemical binding]; other site 1150475009714 Mg2+ binding site [ion binding]; other site 1150475009715 G-X-G motif; other site 1150475009716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475009717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475009718 active site 1150475009719 phosphorylation site [posttranslational modification] 1150475009720 intermolecular recognition site; other site 1150475009721 dimerization interface [polypeptide binding]; other site 1150475009722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475009723 DNA binding site [nucleotide binding] 1150475009724 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1150475009725 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1150475009726 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1150475009727 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1150475009728 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1150475009729 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1150475009730 Walker A/P-loop; other site 1150475009731 ATP binding site [chemical binding]; other site 1150475009732 Q-loop/lid; other site 1150475009733 ABC transporter signature motif; other site 1150475009734 Walker B; other site 1150475009735 D-loop; other site 1150475009736 H-loop/switch region; other site 1150475009737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009738 dimer interface [polypeptide binding]; other site 1150475009739 conserved gate region; other site 1150475009740 putative PBP binding loops; other site 1150475009741 ABC-ATPase subunit interface; other site 1150475009742 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1150475009743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009744 dimer interface [polypeptide binding]; other site 1150475009745 conserved gate region; other site 1150475009746 putative PBP binding loops; other site 1150475009747 ABC-ATPase subunit interface; other site 1150475009748 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1150475009749 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1150475009750 Walker A/P-loop; other site 1150475009751 ATP binding site [chemical binding]; other site 1150475009752 Q-loop/lid; other site 1150475009753 ABC transporter signature motif; other site 1150475009754 Walker B; other site 1150475009755 D-loop; other site 1150475009756 H-loop/switch region; other site 1150475009757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1150475009758 Predicted transcriptional regulators [Transcription]; Region: COG1510 1150475009759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475009760 putative DNA binding site [nucleotide binding]; other site 1150475009761 putative Zn2+ binding site [ion binding]; other site 1150475009762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009763 dimer interface [polypeptide binding]; other site 1150475009764 conserved gate region; other site 1150475009765 putative PBP binding loops; other site 1150475009766 ABC-ATPase subunit interface; other site 1150475009767 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1150475009768 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1150475009769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1150475009770 dimer interface [polypeptide binding]; other site 1150475009771 conserved gate region; other site 1150475009772 putative PBP binding loops; other site 1150475009773 ABC-ATPase subunit interface; other site 1150475009774 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1150475009775 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1150475009776 Walker A/P-loop; other site 1150475009777 ATP binding site [chemical binding]; other site 1150475009778 Q-loop/lid; other site 1150475009779 ABC transporter signature motif; other site 1150475009780 Walker B; other site 1150475009781 D-loop; other site 1150475009782 H-loop/switch region; other site 1150475009783 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1150475009784 Predicted transcriptional regulators [Transcription]; Region: COG1510 1150475009785 MarR family; Region: MarR_2; pfam12802 1150475009786 membrane protein, MarC family; Region: TIGR00427 1150475009787 Predicted membrane protein [Function unknown]; Region: COG4640 1150475009788 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1150475009789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475009790 Coenzyme A binding pocket [chemical binding]; other site 1150475009791 H+ Antiporter protein; Region: 2A0121; TIGR00900 1150475009792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475009793 putative substrate translocation pore; other site 1150475009794 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1150475009795 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1150475009796 WbqC-like protein family; Region: WbqC; pfam08889 1150475009797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1150475009798 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1150475009799 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1150475009800 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1150475009801 catalytic residue [active] 1150475009802 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1150475009803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475009804 NAD(P) binding site [chemical binding]; other site 1150475009805 active site 1150475009806 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1150475009807 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1150475009808 inhibitor-cofactor binding pocket; inhibition site 1150475009809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475009810 catalytic residue [active] 1150475009811 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1150475009812 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1150475009813 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1150475009814 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1150475009815 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1150475009816 putative integrin binding motif; other site 1150475009817 PA/protease domain interface [polypeptide binding]; other site 1150475009818 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1150475009819 Peptidase family M28; Region: Peptidase_M28; pfam04389 1150475009820 metal binding site [ion binding]; metal-binding site 1150475009821 enolase; Provisional; Region: eno; PRK00077 1150475009822 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1150475009823 dimer interface [polypeptide binding]; other site 1150475009824 metal binding site [ion binding]; metal-binding site 1150475009825 substrate binding pocket [chemical binding]; other site 1150475009826 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1150475009827 phosphoglyceromutase; Provisional; Region: PRK05434 1150475009828 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1150475009829 triosephosphate isomerase; Provisional; Region: PRK14565 1150475009830 substrate binding site [chemical binding]; other site 1150475009831 dimer interface [polypeptide binding]; other site 1150475009832 catalytic triad [active] 1150475009833 Phosphoglycerate kinase; Region: PGK; pfam00162 1150475009834 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1150475009835 substrate binding site [chemical binding]; other site 1150475009836 hinge regions; other site 1150475009837 ADP binding site [chemical binding]; other site 1150475009838 catalytic site [active] 1150475009839 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1150475009840 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1150475009841 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1150475009842 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1150475009843 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1150475009844 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1150475009845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475009846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475009847 DNA-binding site [nucleotide binding]; DNA binding site 1150475009848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475009849 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1150475009850 putative dimerization interface [polypeptide binding]; other site 1150475009851 putative ligand binding site [chemical binding]; other site 1150475009852 AAA domain; Region: AAA_22; pfam13401 1150475009853 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1150475009854 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1150475009855 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1150475009856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475009857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475009858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475009859 dimerization interface [polypeptide binding]; other site 1150475009860 EamA-like transporter family; Region: EamA; pfam00892 1150475009861 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1150475009862 EamA-like transporter family; Region: EamA; pfam00892 1150475009863 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1150475009864 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1150475009865 active site 1150475009866 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475009867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475009868 DNA binding site [nucleotide binding] 1150475009869 domain linker motif; other site 1150475009870 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1150475009871 putative ligand binding site [chemical binding]; other site 1150475009872 putative dimerization interface [polypeptide binding]; other site 1150475009873 Predicted membrane protein [Function unknown]; Region: COG2364 1150475009874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475009875 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1150475009876 active site 1150475009877 motif I; other site 1150475009878 motif II; other site 1150475009879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475009880 motif II; other site 1150475009881 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1150475009882 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1150475009883 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1150475009884 putative active site [active] 1150475009885 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1150475009886 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1150475009887 N- and C-terminal domain interface [polypeptide binding]; other site 1150475009888 active site 1150475009889 catalytic site [active] 1150475009890 metal binding site [ion binding]; metal-binding site 1150475009891 carbohydrate binding site [chemical binding]; other site 1150475009892 ATP binding site [chemical binding]; other site 1150475009893 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1150475009894 GntP family permease; Region: GntP_permease; pfam02447 1150475009895 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1150475009896 iron-sulfur cluster-binding protein; Region: TIGR00273 1150475009897 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1150475009898 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1150475009899 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1150475009900 Cysteine-rich domain; Region: CCG; pfam02754 1150475009901 Cysteine-rich domain; Region: CCG; pfam02754 1150475009902 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1150475009903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475009904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475009905 homodimer interface [polypeptide binding]; other site 1150475009906 catalytic residue [active] 1150475009907 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1150475009908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475009909 DNA-binding site [nucleotide binding]; DNA binding site 1150475009910 FCD domain; Region: FCD; pfam07729 1150475009911 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1150475009912 L-lactate permease; Region: Lactate_perm; pfam02652 1150475009913 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1150475009914 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1150475009915 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1150475009916 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1150475009917 YvfG protein; Region: YvfG; pfam09628 1150475009918 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1150475009919 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1150475009920 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1150475009921 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1150475009922 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1150475009923 inhibitor-cofactor binding pocket; inhibition site 1150475009924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475009925 catalytic residue [active] 1150475009926 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1150475009927 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1150475009928 putative trimer interface [polypeptide binding]; other site 1150475009929 putative CoA binding site [chemical binding]; other site 1150475009930 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1150475009931 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1150475009932 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1150475009933 putative glycosyl transferase; Provisional; Region: PRK10073 1150475009934 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1150475009935 active site 1150475009936 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1150475009937 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1150475009938 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1150475009939 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1150475009940 active site 1150475009941 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1150475009942 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1150475009943 putative ADP-binding pocket [chemical binding]; other site 1150475009944 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1150475009945 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1150475009946 active site 1150475009947 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1150475009948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1150475009949 putative ADP-binding pocket [chemical binding]; other site 1150475009950 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1150475009951 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1150475009952 NAD(P) binding site [chemical binding]; other site 1150475009953 homodimer interface [polypeptide binding]; other site 1150475009954 substrate binding site [chemical binding]; other site 1150475009955 active site 1150475009956 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1150475009957 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1150475009958 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1150475009959 Chain length determinant protein; Region: Wzz; cl15801 1150475009960 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1150475009961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475009962 non-specific DNA binding site [nucleotide binding]; other site 1150475009963 salt bridge; other site 1150475009964 sequence-specific DNA binding site [nucleotide binding]; other site 1150475009965 Anti-repressor SinI; Region: SinI; pfam08671 1150475009966 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1150475009967 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1150475009968 substrate binding pocket [chemical binding]; other site 1150475009969 catalytic triad [active] 1150475009970 RibD C-terminal domain; Region: RibD_C; cl17279 1150475009971 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1150475009972 Predicted membrane protein [Function unknown]; Region: COG2364 1150475009973 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1150475009974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475009975 Coenzyme A binding pocket [chemical binding]; other site 1150475009976 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1150475009977 hypothetical protein; Provisional; Region: PRK00872 1150475009978 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1150475009979 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1150475009980 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1150475009981 substrate binding [chemical binding]; other site 1150475009982 active site 1150475009983 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1150475009984 galactoside permease; Reviewed; Region: lacY; PRK09528 1150475009985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475009986 putative substrate translocation pore; other site 1150475009987 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475009988 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475009989 DNA binding site [nucleotide binding] 1150475009990 domain linker motif; other site 1150475009991 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1150475009992 dimerization interface [polypeptide binding]; other site 1150475009993 ligand binding site [chemical binding]; other site 1150475009994 sodium binding site [ion binding]; other site 1150475009995 Clp protease; Region: CLP_protease; pfam00574 1150475009996 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1150475009997 oligomer interface [polypeptide binding]; other site 1150475009998 active site residues [active] 1150475009999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475010000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475010001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475010002 dimerization interface [polypeptide binding]; other site 1150475010003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1150475010004 benzoate transport; Region: 2A0115; TIGR00895 1150475010005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010006 putative substrate translocation pore; other site 1150475010007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010008 TIGR00730 family protein; Region: TIGR00730 1150475010009 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1150475010010 metal binding site [ion binding]; metal-binding site 1150475010011 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1150475010012 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1150475010013 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1150475010014 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1150475010015 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1150475010016 active site clefts [active] 1150475010017 zinc binding site [ion binding]; other site 1150475010018 dimer interface [polypeptide binding]; other site 1150475010019 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1150475010020 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1150475010021 dimerization interface [polypeptide binding]; other site 1150475010022 ligand binding site [chemical binding]; other site 1150475010023 NADP binding site [chemical binding]; other site 1150475010024 catalytic site [active] 1150475010025 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1150475010026 active site 1150475010027 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1150475010028 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1150475010029 dimerization domain swap beta strand [polypeptide binding]; other site 1150475010030 regulatory protein interface [polypeptide binding]; other site 1150475010031 active site 1150475010032 regulatory phosphorylation site [posttranslational modification]; other site 1150475010033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1150475010034 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1150475010035 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1150475010036 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1150475010037 phosphate binding site [ion binding]; other site 1150475010038 putative substrate binding pocket [chemical binding]; other site 1150475010039 dimer interface [polypeptide binding]; other site 1150475010040 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1150475010041 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1150475010042 putative active site [active] 1150475010043 nucleotide binding site [chemical binding]; other site 1150475010044 nudix motif; other site 1150475010045 putative metal binding site [ion binding]; other site 1150475010046 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1150475010047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1150475010048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475010049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1150475010050 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 1150475010051 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1150475010052 NlpC/P60 family; Region: NLPC_P60; pfam00877 1150475010053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475010054 binding surface 1150475010055 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1150475010056 TPR motif; other site 1150475010057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475010058 TPR motif; other site 1150475010059 binding surface 1150475010060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475010061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475010062 dimer interface [polypeptide binding]; other site 1150475010063 phosphorylation site [posttranslational modification] 1150475010064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475010065 ATP binding site [chemical binding]; other site 1150475010066 Mg2+ binding site [ion binding]; other site 1150475010067 G-X-G motif; other site 1150475010068 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475010069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475010070 active site 1150475010071 phosphorylation site [posttranslational modification] 1150475010072 intermolecular recognition site; other site 1150475010073 dimerization interface [polypeptide binding]; other site 1150475010074 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475010075 DNA binding site [nucleotide binding] 1150475010076 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1150475010077 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475010078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475010079 Walker A/P-loop; other site 1150475010080 ATP binding site [chemical binding]; other site 1150475010081 Q-loop/lid; other site 1150475010082 ABC transporter signature motif; other site 1150475010083 Walker B; other site 1150475010084 D-loop; other site 1150475010085 H-loop/switch region; other site 1150475010086 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1150475010087 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1150475010088 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1150475010089 metal binding site [ion binding]; metal-binding site 1150475010090 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1150475010091 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1150475010092 substrate binding site [chemical binding]; other site 1150475010093 glutamase interaction surface [polypeptide binding]; other site 1150475010094 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1150475010095 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1150475010096 catalytic residues [active] 1150475010097 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1150475010098 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1150475010099 putative active site [active] 1150475010100 oxyanion strand; other site 1150475010101 catalytic triad [active] 1150475010102 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1150475010103 putative active site pocket [active] 1150475010104 4-fold oligomerization interface [polypeptide binding]; other site 1150475010105 metal binding residues [ion binding]; metal-binding site 1150475010106 3-fold/trimer interface [polypeptide binding]; other site 1150475010107 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1150475010108 histidinol dehydrogenase; Region: hisD; TIGR00069 1150475010109 NAD binding site [chemical binding]; other site 1150475010110 dimerization interface [polypeptide binding]; other site 1150475010111 product binding site; other site 1150475010112 substrate binding site [chemical binding]; other site 1150475010113 zinc binding site [ion binding]; other site 1150475010114 catalytic residues [active] 1150475010115 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1150475010116 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1150475010117 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1150475010118 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1150475010119 dimer interface [polypeptide binding]; other site 1150475010120 motif 1; other site 1150475010121 active site 1150475010122 motif 2; other site 1150475010123 motif 3; other site 1150475010124 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1150475010125 putative active site [active] 1150475010126 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1150475010127 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1150475010128 trimer interface [polypeptide binding]; other site 1150475010129 active site 1150475010130 substrate binding site [chemical binding]; other site 1150475010131 CoA binding site [chemical binding]; other site 1150475010132 pyrophosphatase PpaX; Provisional; Region: PRK13288 1150475010133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475010134 active site 1150475010135 motif I; other site 1150475010136 motif II; other site 1150475010137 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1150475010138 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1150475010139 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1150475010140 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1150475010141 Hpr binding site; other site 1150475010142 active site 1150475010143 homohexamer subunit interaction site [polypeptide binding]; other site 1150475010144 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1150475010145 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1150475010146 active site 1150475010147 dimer interface [polypeptide binding]; other site 1150475010148 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1150475010149 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1150475010150 active site 1150475010151 trimer interface [polypeptide binding]; other site 1150475010152 allosteric site; other site 1150475010153 active site lid [active] 1150475010154 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1150475010155 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1150475010156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475010157 DNA-binding site [nucleotide binding]; DNA binding site 1150475010158 UTRA domain; Region: UTRA; pfam07702 1150475010159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475010160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475010161 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1150475010162 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1150475010163 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1150475010164 putative active site [active] 1150475010165 putative metal binding site [ion binding]; other site 1150475010166 Predicted membrane protein [Function unknown]; Region: COG1950 1150475010167 PspC domain; Region: PspC; pfam04024 1150475010168 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1150475010169 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1150475010170 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1150475010171 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1150475010172 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1150475010173 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1150475010174 excinuclease ABC subunit B; Provisional; Region: PRK05298 1150475010175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475010176 ATP binding site [chemical binding]; other site 1150475010177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475010178 nucleotide binding region [chemical binding]; other site 1150475010179 ATP-binding site [chemical binding]; other site 1150475010180 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1150475010181 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1150475010182 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1150475010183 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1150475010184 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1150475010185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475010186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475010187 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1150475010188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010189 putative substrate translocation pore; other site 1150475010190 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1150475010191 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 1150475010192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475010193 NAD(P) binding site [chemical binding]; other site 1150475010194 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1150475010195 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475010196 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1150475010197 Walker A/P-loop; other site 1150475010198 ATP binding site [chemical binding]; other site 1150475010199 Q-loop/lid; other site 1150475010200 ABC transporter signature motif; other site 1150475010201 Walker B; other site 1150475010202 D-loop; other site 1150475010203 H-loop/switch region; other site 1150475010204 acyl-CoA synthetase; Validated; Region: PRK09192 1150475010205 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1150475010206 acyl-activating enzyme (AAE) consensus motif; other site 1150475010207 AMP binding site [chemical binding]; other site 1150475010208 active site 1150475010209 CoA binding site [chemical binding]; other site 1150475010210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1150475010211 Condensation domain; Region: Condensation; pfam00668 1150475010212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1150475010213 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1150475010214 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1150475010215 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1150475010216 acyl-activating enzyme (AAE) consensus motif; other site 1150475010217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475010218 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1150475010219 active site 1150475010220 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1150475010221 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1150475010222 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1150475010223 C-terminal peptidase (prc); Region: prc; TIGR00225 1150475010224 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1150475010225 protein binding site [polypeptide binding]; other site 1150475010226 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1150475010227 Catalytic dyad [active] 1150475010228 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1150475010229 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1150475010230 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1150475010231 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1150475010232 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1150475010233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475010234 Walker A/P-loop; other site 1150475010235 ATP binding site [chemical binding]; other site 1150475010236 Q-loop/lid; other site 1150475010237 ABC transporter signature motif; other site 1150475010238 Walker B; other site 1150475010239 D-loop; other site 1150475010240 H-loop/switch region; other site 1150475010241 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1150475010242 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1150475010243 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1150475010244 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475010245 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475010246 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1150475010247 peptide chain release factor 2; Provisional; Region: PRK06746 1150475010248 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1150475010249 RF-1 domain; Region: RF-1; pfam00472 1150475010250 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1150475010251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1150475010252 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1150475010253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1150475010254 nucleotide binding region [chemical binding]; other site 1150475010255 ATP-binding site [chemical binding]; other site 1150475010256 SEC-C motif; Region: SEC-C; pfam02810 1150475010257 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1150475010258 30S subunit binding site; other site 1150475010259 Flagellar protein FliT; Region: FliT; pfam05400 1150475010260 flagellar protein FliS; Validated; Region: fliS; PRK05685 1150475010261 flagellar capping protein; Validated; Region: fliD; PRK07737 1150475010262 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1150475010263 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1150475010264 flagellin; Provisional; Region: PRK12804 1150475010265 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1150475010266 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1150475010267 carbon storage regulator; Provisional; Region: PRK01712 1150475010268 flagellar assembly protein FliW; Provisional; Region: PRK13285 1150475010269 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1150475010270 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1150475010271 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1150475010272 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1150475010273 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1150475010274 FlgN protein; Region: FlgN; pfam05130 1150475010275 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1150475010276 flagellar operon protein TIGR03826; Region: YvyF 1150475010277 comF family protein; Region: comF; TIGR00201 1150475010278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475010279 active site 1150475010280 Late competence development protein ComFB; Region: ComFB; pfam10719 1150475010281 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1150475010282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475010283 ATP binding site [chemical binding]; other site 1150475010284 putative Mg++ binding site [ion binding]; other site 1150475010285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475010286 nucleotide binding region [chemical binding]; other site 1150475010287 ATP-binding site [chemical binding]; other site 1150475010288 EDD domain protein, DegV family; Region: DegV; TIGR00762 1150475010289 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1150475010290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475010291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475010292 active site 1150475010293 phosphorylation site [posttranslational modification] 1150475010294 intermolecular recognition site; other site 1150475010295 dimerization interface [polypeptide binding]; other site 1150475010296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475010297 DNA binding residues [nucleotide binding] 1150475010298 dimerization interface [polypeptide binding]; other site 1150475010299 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1150475010300 Histidine kinase; Region: HisKA_3; pfam07730 1150475010301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475010302 ATP binding site [chemical binding]; other site 1150475010303 Mg2+ binding site [ion binding]; other site 1150475010304 G-X-G motif; other site 1150475010305 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1150475010306 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1150475010307 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1150475010308 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1150475010309 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1150475010310 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1150475010311 Mg++ binding site [ion binding]; other site 1150475010312 putative catalytic motif [active] 1150475010313 substrate binding site [chemical binding]; other site 1150475010314 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1150475010315 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1150475010316 putative homodimer interface [polypeptide binding]; other site 1150475010317 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1150475010318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1150475010319 active site 1150475010320 O-Antigen ligase; Region: Wzy_C; pfam04932 1150475010321 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1150475010322 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1150475010323 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1150475010324 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1150475010325 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1150475010326 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1150475010327 colanic acid exporter; Provisional; Region: PRK10459 1150475010328 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1150475010329 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1150475010330 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1150475010331 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1150475010332 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1150475010333 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1150475010334 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1150475010335 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1150475010336 active site 1150475010337 metal binding site [ion binding]; metal-binding site 1150475010338 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1150475010339 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1150475010340 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1150475010341 Stage II sporulation protein; Region: SpoIID; pfam08486 1150475010342 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1150475010343 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1150475010344 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1150475010345 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1150475010346 active site 1150475010347 homodimer interface [polypeptide binding]; other site 1150475010348 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1150475010349 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1150475010350 active site 1150475010351 tetramer interface; other site 1150475010352 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1150475010353 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1150475010354 Walker A/P-loop; other site 1150475010355 ATP binding site [chemical binding]; other site 1150475010356 Q-loop/lid; other site 1150475010357 ABC transporter signature motif; other site 1150475010358 Walker B; other site 1150475010359 D-loop; other site 1150475010360 H-loop/switch region; other site 1150475010361 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1150475010362 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1150475010363 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1150475010364 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1150475010365 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1150475010366 active site 1150475010367 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1150475010368 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1150475010369 active site 1150475010370 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1150475010371 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1150475010372 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1150475010373 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1150475010374 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1150475010375 Bacterial SH3 domain; Region: SH3_3; pfam08239 1150475010376 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1150475010377 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1150475010378 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1150475010379 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1150475010380 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1150475010381 Spore germination protein; Region: Spore_permease; pfam03845 1150475010382 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1150475010383 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1150475010384 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1150475010385 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1150475010386 Probable Catalytic site; other site 1150475010387 metal-binding site 1150475010388 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1150475010389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475010390 S-adenosylmethionine binding site [chemical binding]; other site 1150475010391 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1150475010392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010393 putative substrate translocation pore; other site 1150475010394 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1150475010395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475010396 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1150475010397 active site 1150475010398 motif I; other site 1150475010399 motif II; other site 1150475010400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475010401 Septum formation initiator; Region: DivIC; cl17659 1150475010402 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1150475010403 NlpC/P60 family; Region: NLPC_P60; pfam00877 1150475010404 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1150475010405 NlpC/P60 family; Region: NLPC_P60; pfam00877 1150475010406 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1150475010407 NlpC/P60 family; Region: NLPC_P60; pfam00877 1150475010408 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1150475010409 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1150475010410 putative active site [active] 1150475010411 putative metal binding site [ion binding]; other site 1150475010412 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1150475010413 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1150475010414 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1150475010415 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1150475010416 Spore germination protein; Region: Spore_permease; cl17796 1150475010417 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1150475010418 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1150475010419 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475010420 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475010421 DNA binding site [nucleotide binding] 1150475010422 domain linker motif; other site 1150475010423 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1150475010424 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1150475010425 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1150475010426 substrate binding site [chemical binding]; other site 1150475010427 dimer interface [polypeptide binding]; other site 1150475010428 ATP binding site [chemical binding]; other site 1150475010429 D-ribose pyranase; Provisional; Region: PRK11797 1150475010430 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1150475010431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475010432 Walker A/P-loop; other site 1150475010433 ATP binding site [chemical binding]; other site 1150475010434 Q-loop/lid; other site 1150475010435 ABC transporter signature motif; other site 1150475010436 Walker B; other site 1150475010437 D-loop; other site 1150475010438 H-loop/switch region; other site 1150475010439 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1150475010440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1150475010441 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1150475010442 TM-ABC transporter signature motif; other site 1150475010443 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1150475010444 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1150475010445 ligand binding site [chemical binding]; other site 1150475010446 dimerization interface [polypeptide binding]; other site 1150475010447 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1150475010448 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1150475010449 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1150475010450 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1150475010451 acetolactate synthase; Reviewed; Region: PRK08617 1150475010452 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1150475010453 PYR/PP interface [polypeptide binding]; other site 1150475010454 dimer interface [polypeptide binding]; other site 1150475010455 TPP binding site [chemical binding]; other site 1150475010456 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1150475010457 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1150475010458 TPP-binding site [chemical binding]; other site 1150475010459 dimer interface [polypeptide binding]; other site 1150475010460 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1150475010461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475010462 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1150475010463 putative dimerization interface [polypeptide binding]; other site 1150475010464 putative substrate binding pocket [chemical binding]; other site 1150475010465 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1150475010466 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1150475010467 transmembrane helices; other site 1150475010468 CotH protein; Region: CotH; pfam08757 1150475010469 Evidence 4 : Homologs of previously reported genes of unknown function 1150475010470 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1150475010471 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1150475010472 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1150475010473 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1150475010474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475010475 putative DNA binding site [nucleotide binding]; other site 1150475010476 putative Zn2+ binding site [ion binding]; other site 1150475010477 AsnC family; Region: AsnC_trans_reg; pfam01037 1150475010478 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1150475010479 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1150475010480 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1150475010481 Active_site [active] 1150475010482 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1150475010483 Integrase core domain; Region: rve; pfam00665 1150475010484 Integrase core domain; Region: rve_2; pfam13333 1150475010485 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 1150475010486 Evidence 5 : No homology to any previously reported sequences 1150475010487 HTH-like domain; Region: HTH_21; pfam13276 1150475010488 Integrase core domain; Region: rve; pfam00665 1150475010489 Integrase core domain; Region: rve_2; pfam13333 1150475010490 LXG domain of WXG superfamily; Region: LXG; pfam04740 1150475010491 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1150475010492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1150475010493 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1150475010494 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1150475010495 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1150475010496 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1150475010497 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1150475010498 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1150475010499 active site 1150475010500 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1150475010501 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1150475010502 Nucleotide binding site [chemical binding]; other site 1150475010503 DTAP/Switch II; other site 1150475010504 Switch I; other site 1150475010505 Chain length determinant protein; Region: Wzz; cl15801 1150475010506 SWIM zinc finger; Region: SWIM; pfam04434 1150475010507 SNF2 Helicase protein; Region: DUF3670; pfam12419 1150475010508 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1150475010509 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1150475010510 ATP binding site [chemical binding]; other site 1150475010511 putative Mg++ binding site [ion binding]; other site 1150475010512 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1150475010513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475010514 nucleotide binding region [chemical binding]; other site 1150475010515 ATP-binding site [chemical binding]; other site 1150475010516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475010517 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1150475010518 active site 1150475010519 motif I; other site 1150475010520 motif II; other site 1150475010521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475010522 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1150475010523 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1150475010524 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1150475010525 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1150475010526 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1150475010527 dimer interface [polypeptide binding]; other site 1150475010528 ssDNA binding site [nucleotide binding]; other site 1150475010529 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1150475010530 YwpF-like protein; Region: YwpF; pfam14183 1150475010531 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1150475010532 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1150475010533 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1150475010534 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475010535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475010536 binding surface 1150475010537 TPR motif; other site 1150475010538 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475010539 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1150475010540 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1150475010541 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1150475010542 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1150475010543 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1150475010544 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1150475010545 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1150475010546 MreB and similar proteins; Region: MreB_like; cd10225 1150475010547 nucleotide binding site [chemical binding]; other site 1150475010548 Mg binding site [ion binding]; other site 1150475010549 putative protofilament interaction site [polypeptide binding]; other site 1150475010550 RodZ interaction site [polypeptide binding]; other site 1150475010551 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1150475010552 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475010553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475010554 putative Zn2+ binding site [ion binding]; other site 1150475010555 putative DNA binding site [nucleotide binding]; other site 1150475010556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010557 putative substrate translocation pore; other site 1150475010558 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475010559 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1150475010560 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1150475010561 Na binding site [ion binding]; other site 1150475010562 putative substrate binding site [chemical binding]; other site 1150475010563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475010565 putative substrate translocation pore; other site 1150475010566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010567 Isochorismatase family; Region: Isochorismatase; pfam00857 1150475010568 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1150475010569 catalytic triad [active] 1150475010570 conserved cis-peptide bond; other site 1150475010571 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1150475010572 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1150475010573 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1150475010574 cell division protein FtsW; Region: ftsW; TIGR02614 1150475010575 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1150475010576 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1150475010577 active site 1150475010578 VanZ like family; Region: VanZ; pfam04892 1150475010579 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1150475010580 Peptidase family M23; Region: Peptidase_M23; pfam01551 1150475010581 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1150475010582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475010583 Coenzyme A binding pocket [chemical binding]; other site 1150475010584 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1150475010585 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1150475010586 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1150475010587 putative active site [active] 1150475010588 catalytic site [active] 1150475010589 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1150475010590 putative active site [active] 1150475010591 catalytic site [active] 1150475010592 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1150475010593 Predicted transcriptional regulator [Transcription]; Region: COG1959 1150475010594 Transcriptional regulator; Region: Rrf2; pfam02082 1150475010595 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1150475010596 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1150475010597 subunit interactions [polypeptide binding]; other site 1150475010598 active site 1150475010599 flap region; other site 1150475010600 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1150475010601 gamma-beta subunit interface [polypeptide binding]; other site 1150475010602 alpha-beta subunit interface [polypeptide binding]; other site 1150475010603 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1150475010604 alpha-gamma subunit interface [polypeptide binding]; other site 1150475010605 beta-gamma subunit interface [polypeptide binding]; other site 1150475010606 CsbD-like; Region: CsbD; pfam05532 1150475010607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475010608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475010609 binding surface 1150475010610 TPR motif; other site 1150475010611 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1150475010612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1150475010613 FeS/SAM binding site; other site 1150475010614 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1150475010615 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1150475010616 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1150475010617 metal ion-dependent adhesion site (MIDAS); other site 1150475010618 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1150475010619 metal ion-dependent adhesion site (MIDAS); other site 1150475010620 Stage II sporulation protein; Region: SpoIID; pfam08486 1150475010621 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1150475010622 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1150475010623 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1150475010624 hinge; other site 1150475010625 active site 1150475010626 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1150475010627 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1150475010628 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1150475010629 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1150475010630 gamma subunit interface [polypeptide binding]; other site 1150475010631 epsilon subunit interface [polypeptide binding]; other site 1150475010632 LBP interface [polypeptide binding]; other site 1150475010633 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1150475010634 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1150475010635 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1150475010636 alpha subunit interaction interface [polypeptide binding]; other site 1150475010637 Walker A motif; other site 1150475010638 ATP binding site [chemical binding]; other site 1150475010639 Walker B motif; other site 1150475010640 inhibitor binding site; inhibition site 1150475010641 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1150475010642 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1150475010643 core domain interface [polypeptide binding]; other site 1150475010644 delta subunit interface [polypeptide binding]; other site 1150475010645 epsilon subunit interface [polypeptide binding]; other site 1150475010646 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1150475010647 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1150475010648 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1150475010649 beta subunit interaction interface [polypeptide binding]; other site 1150475010650 Walker A motif; other site 1150475010651 ATP binding site [chemical binding]; other site 1150475010652 Walker B motif; other site 1150475010653 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1150475010654 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1150475010655 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1150475010656 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1150475010657 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1150475010658 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1150475010659 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1150475010660 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1150475010661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1150475010662 active site 1150475010663 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1150475010664 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1150475010665 dimer interface [polypeptide binding]; other site 1150475010666 active site 1150475010667 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1150475010668 folate binding site [chemical binding]; other site 1150475010669 hypothetical protein; Provisional; Region: PRK13690 1150475010670 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1150475010671 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1150475010672 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1150475010673 active site 1150475010674 Predicted membrane protein [Function unknown]; Region: COG1971 1150475010675 Domain of unknown function DUF; Region: DUF204; pfam02659 1150475010676 Domain of unknown function DUF; Region: DUF204; pfam02659 1150475010677 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1150475010678 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1150475010679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1150475010680 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1150475010681 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1150475010682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475010683 S-adenosylmethionine binding site [chemical binding]; other site 1150475010684 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1150475010685 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1150475010686 RF-1 domain; Region: RF-1; pfam00472 1150475010687 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1150475010688 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475010689 putative metal binding site [ion binding]; other site 1150475010690 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1150475010691 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1150475010692 DNA binding residues [nucleotide binding] 1150475010693 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1150475010694 malate dehydrogenase; Provisional; Region: PRK13529 1150475010695 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1150475010696 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1150475010697 NAD(P) binding site [chemical binding]; other site 1150475010698 thymidine kinase; Provisional; Region: PRK04296 1150475010699 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1150475010700 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1150475010701 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1150475010702 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1150475010703 RNA binding site [nucleotide binding]; other site 1150475010704 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1150475010705 multimer interface [polypeptide binding]; other site 1150475010706 Walker A motif; other site 1150475010707 ATP binding site [chemical binding]; other site 1150475010708 Walker B motif; other site 1150475010709 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1150475010710 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1150475010711 putative active site [active] 1150475010712 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1150475010713 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1150475010714 hinge; other site 1150475010715 active site 1150475010716 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1150475010717 active site 1150475010718 intersubunit interactions; other site 1150475010719 catalytic residue [active] 1150475010720 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1150475010721 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1150475010722 intersubunit interface [polypeptide binding]; other site 1150475010723 active site 1150475010724 zinc binding site [ion binding]; other site 1150475010725 Na+ binding site [ion binding]; other site 1150475010726 Response regulator receiver domain; Region: Response_reg; pfam00072 1150475010727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475010728 active site 1150475010729 phosphorylation site [posttranslational modification] 1150475010730 intermolecular recognition site; other site 1150475010731 dimerization interface [polypeptide binding]; other site 1150475010732 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1150475010733 CTP synthetase; Validated; Region: pyrG; PRK05380 1150475010734 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1150475010735 Catalytic site [active] 1150475010736 active site 1150475010737 UTP binding site [chemical binding]; other site 1150475010738 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1150475010739 active site 1150475010740 putative oxyanion hole; other site 1150475010741 catalytic triad [active] 1150475010742 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1150475010743 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1150475010744 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1150475010745 Cysteine-rich domain; Region: CCG; pfam02754 1150475010746 Cysteine-rich domain; Region: CCG; pfam02754 1150475010747 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1150475010748 putative active site [active] 1150475010749 catalytic site [active] 1150475010750 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1150475010751 PLD-like domain; Region: PLDc_2; pfam13091 1150475010752 putative active site [active] 1150475010753 catalytic site [active] 1150475010754 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1150475010755 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1150475010756 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475010757 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1150475010758 Walker A/P-loop; other site 1150475010759 ATP binding site [chemical binding]; other site 1150475010760 Q-loop/lid; other site 1150475010761 ABC transporter signature motif; other site 1150475010762 Walker B; other site 1150475010763 D-loop; other site 1150475010764 H-loop/switch region; other site 1150475010765 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1150475010766 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1150475010767 putative active site [active] 1150475010768 catalytic site [active] 1150475010769 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1150475010770 putative active site [active] 1150475010771 catalytic site [active] 1150475010772 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1150475010773 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475010774 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1150475010775 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1150475010776 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1150475010777 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1150475010778 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1150475010779 [4Fe-4S] binding site [ion binding]; other site 1150475010780 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1150475010781 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1150475010782 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1150475010783 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1150475010784 molybdopterin cofactor binding site; other site 1150475010785 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1150475010786 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1150475010787 ligand binding site [chemical binding]; other site 1150475010788 flexible hinge region; other site 1150475010789 YwiC-like protein; Region: YwiC; pfam14256 1150475010790 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1150475010791 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1150475010792 ligand binding site [chemical binding]; other site 1150475010793 flexible hinge region; other site 1150475010794 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1150475010795 putative switch regulator; other site 1150475010796 non-specific DNA interactions [nucleotide binding]; other site 1150475010797 DNA binding site [nucleotide binding] 1150475010798 sequence specific DNA binding site [nucleotide binding]; other site 1150475010799 putative cAMP binding site [chemical binding]; other site 1150475010800 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1150475010801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010802 putative substrate translocation pore; other site 1150475010803 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1150475010804 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1150475010805 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1150475010806 active site 1150475010807 HIGH motif; other site 1150475010808 KMSK motif region; other site 1150475010809 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1150475010810 tRNA binding surface [nucleotide binding]; other site 1150475010811 anticodon binding site; other site 1150475010812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1150475010813 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1150475010814 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1150475010815 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1150475010816 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1150475010817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475010818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1150475010819 binding surface 1150475010820 TPR motif; other site 1150475010821 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475010822 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1150475010823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1150475010824 non-specific DNA binding site [nucleotide binding]; other site 1150475010825 salt bridge; other site 1150475010826 sequence-specific DNA binding site [nucleotide binding]; other site 1150475010827 Integral membrane protein DUF95; Region: DUF95; pfam01944 1150475010828 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 1150475010829 agmatinase; Region: agmatinase; TIGR01230 1150475010830 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1150475010831 putative active site [active] 1150475010832 Mn binding site [ion binding]; other site 1150475010833 spermidine synthase; Provisional; Region: PRK00811 1150475010834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1150475010835 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1150475010836 Transglycosylase; Region: Transgly; pfam00912 1150475010837 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1150475010838 YwhD family; Region: YwhD; pfam08741 1150475010839 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1150475010840 Peptidase family M50; Region: Peptidase_M50; pfam02163 1150475010841 active site 1150475010842 putative substrate binding region [chemical binding]; other site 1150475010843 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1150475010844 active site 1 [active] 1150475010845 dimer interface [polypeptide binding]; other site 1150475010846 hexamer interface [polypeptide binding]; other site 1150475010847 active site 2 [active] 1150475010848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475010849 dimerization interface [polypeptide binding]; other site 1150475010850 putative DNA binding site [nucleotide binding]; other site 1150475010851 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475010852 putative Zn2+ binding site [ion binding]; other site 1150475010853 amino acid transporter; Region: 2A0306; TIGR00909 1150475010854 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1150475010855 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1150475010856 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1150475010857 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1150475010858 Zn2+ binding site [ion binding]; other site 1150475010859 Mg2+ binding site [ion binding]; other site 1150475010860 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1150475010861 Predicted transcriptional regulators [Transcription]; Region: COG1695 1150475010862 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1150475010863 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1150475010864 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475010865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475010866 Walker A/P-loop; other site 1150475010867 ATP binding site [chemical binding]; other site 1150475010868 Q-loop/lid; other site 1150475010869 ABC transporter signature motif; other site 1150475010870 Walker B; other site 1150475010871 D-loop; other site 1150475010872 H-loop/switch region; other site 1150475010873 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1150475010874 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1150475010875 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1150475010876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475010877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475010878 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1150475010879 putative dimerization interface [polypeptide binding]; other site 1150475010880 Predicted membrane protein [Function unknown]; Region: COG2855 1150475010881 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1150475010882 putative heme peroxidase; Provisional; Region: PRK12276 1150475010883 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1150475010884 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1150475010885 putative NAD(P) binding site [chemical binding]; other site 1150475010886 putative active site [active] 1150475010887 transaminase; Reviewed; Region: PRK08068 1150475010888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475010889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475010890 homodimer interface [polypeptide binding]; other site 1150475010891 catalytic residue [active] 1150475010892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010893 H+ Antiporter protein; Region: 2A0121; TIGR00900 1150475010894 putative substrate translocation pore; other site 1150475010895 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1150475010896 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1150475010897 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1150475010898 classical (c) SDRs; Region: SDR_c; cd05233 1150475010899 NAD(P) binding site [chemical binding]; other site 1150475010900 active site 1150475010901 Cupin domain; Region: Cupin_2; pfam07883 1150475010902 Cupin domain; Region: Cupin_2; pfam07883 1150475010903 Prephenate dehydratase; Region: PDT; pfam00800 1150475010904 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475010905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010906 putative substrate translocation pore; other site 1150475010907 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1150475010908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475010909 putative substrate translocation pore; other site 1150475010910 S-methylmethionine transporter; Provisional; Region: PRK11387 1150475010911 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1150475010912 putative metal binding site [ion binding]; other site 1150475010913 putative dimer interface [polypeptide binding]; other site 1150475010914 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1150475010915 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1150475010916 Glutamate binding site [chemical binding]; other site 1150475010917 homodimer interface [polypeptide binding]; other site 1150475010918 NAD binding site [chemical binding]; other site 1150475010919 catalytic residues [active] 1150475010920 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1150475010921 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1150475010922 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1150475010923 NAD(P) binding site [chemical binding]; other site 1150475010924 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1150475010925 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1150475010926 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1150475010927 NADP binding site [chemical binding]; other site 1150475010928 active site 1150475010929 putative substrate binding site [chemical binding]; other site 1150475010930 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1150475010931 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1150475010932 NAD binding site [chemical binding]; other site 1150475010933 substrate binding site [chemical binding]; other site 1150475010934 homodimer interface [polypeptide binding]; other site 1150475010935 active site 1150475010936 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1150475010937 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1150475010938 substrate binding site; other site 1150475010939 tetramer interface; other site 1150475010940 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1150475010941 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1150475010942 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1150475010943 ligand binding site; other site 1150475010944 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1150475010945 NeuB family; Region: NeuB; pfam03102 1150475010946 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1150475010947 NeuB binding interface [polypeptide binding]; other site 1150475010948 putative substrate binding site [chemical binding]; other site 1150475010949 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1150475010950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475010951 Coenzyme A binding pocket [chemical binding]; other site 1150475010952 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1150475010953 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1150475010954 inhibitor-cofactor binding pocket; inhibition site 1150475010955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475010956 catalytic residue [active] 1150475010957 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1150475010958 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1150475010959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1150475010960 active site 1150475010961 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1150475010962 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1150475010963 Permease family; Region: Xan_ur_permease; pfam00860 1150475010964 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1150475010965 ligand binding site [chemical binding]; other site 1150475010966 active site 1150475010967 UGI interface [polypeptide binding]; other site 1150475010968 catalytic site [active] 1150475010969 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1150475010970 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1150475010971 active site 1150475010972 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1150475010973 dimer interface [polypeptide binding]; other site 1150475010974 substrate binding site [chemical binding]; other site 1150475010975 ATP binding site [chemical binding]; other site 1150475010976 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1150475010977 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1150475010978 substrate binding [chemical binding]; other site 1150475010979 active site 1150475010980 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1150475010981 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1150475010982 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1150475010983 active site turn [active] 1150475010984 phosphorylation site [posttranslational modification] 1150475010985 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1150475010986 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1150475010987 CAT RNA binding domain; Region: CAT_RBD; smart01061 1150475010988 PRD domain; Region: PRD; pfam00874 1150475010989 PRD domain; Region: PRD; pfam00874 1150475010990 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1150475010991 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1150475010992 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1150475010993 putative active site [active] 1150475010994 catalytic triad [active] 1150475010995 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1150475010996 PA/protease domain interface [polypeptide binding]; other site 1150475010997 putative integrin binding motif; other site 1150475010998 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1150475010999 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1150475011000 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1150475011001 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1150475011002 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1150475011003 dimer interface [polypeptide binding]; other site 1150475011004 FMN binding site [chemical binding]; other site 1150475011005 NADPH bind site [chemical binding]; other site 1150475011006 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1150475011007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475011008 Coenzyme A binding pocket [chemical binding]; other site 1150475011009 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1150475011010 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1150475011011 Subunit I/III interface [polypeptide binding]; other site 1150475011012 Subunit III/IV interface [polypeptide binding]; other site 1150475011013 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1150475011014 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1150475011015 D-pathway; other site 1150475011016 Putative ubiquinol binding site [chemical binding]; other site 1150475011017 Low-spin heme (heme b) binding site [chemical binding]; other site 1150475011018 Putative water exit pathway; other site 1150475011019 Binuclear center (heme o3/CuB) [ion binding]; other site 1150475011020 K-pathway; other site 1150475011021 Putative proton exit pathway; other site 1150475011022 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1150475011023 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1150475011024 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1150475011025 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1150475011026 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1150475011027 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1150475011028 galactokinase; Provisional; Region: PRK05322 1150475011029 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1150475011030 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1150475011031 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1150475011032 Predicted membrane protein [Function unknown]; Region: COG2246 1150475011033 GtrA-like protein; Region: GtrA; pfam04138 1150475011034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475011035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475011036 Anti-repressor SinI; Region: SinI; pfam08671 1150475011037 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1150475011038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475011039 S-adenosylmethionine binding site [chemical binding]; other site 1150475011040 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1150475011041 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1150475011042 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1150475011043 catalytic residues [active] 1150475011044 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1150475011045 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1150475011046 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1150475011047 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1150475011048 thiamine phosphate binding site [chemical binding]; other site 1150475011049 active site 1150475011050 pyrophosphate binding site [ion binding]; other site 1150475011051 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1150475011052 substrate binding site [chemical binding]; other site 1150475011053 multimerization interface [polypeptide binding]; other site 1150475011054 ATP binding site [chemical binding]; other site 1150475011055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475011056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475011057 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1150475011058 putative dimerization interface [polypeptide binding]; other site 1150475011059 holin-like protein; Validated; Region: PRK01658 1150475011060 TIGR00659 family protein; Region: TIGR00659 1150475011061 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1150475011062 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1150475011063 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1150475011064 DNA binding residues [nucleotide binding] 1150475011065 dimer interface [polypeptide binding]; other site 1150475011066 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1150475011067 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1150475011068 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1150475011069 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1150475011070 putative RNA binding site [nucleotide binding]; other site 1150475011071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475011072 S-adenosylmethionine binding site [chemical binding]; other site 1150475011073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475011074 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1150475011075 active site 1150475011076 metal binding site [ion binding]; metal-binding site 1150475011077 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1150475011078 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1150475011079 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1150475011080 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1150475011081 active site 1150475011082 catalytic residues [active] 1150475011083 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1150475011084 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1150475011085 Ligand binding site; other site 1150475011086 metal-binding site 1150475011087 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1150475011088 synthetase active site [active] 1150475011089 NTP binding site [chemical binding]; other site 1150475011090 metal binding site [ion binding]; metal-binding site 1150475011091 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1150475011092 UbiA prenyltransferase family; Region: UbiA; pfam01040 1150475011093 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1150475011094 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1150475011095 acyl-activating enzyme (AAE) consensus motif; other site 1150475011096 AMP binding site [chemical binding]; other site 1150475011097 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1150475011098 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1150475011099 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1150475011100 DltD N-terminal region; Region: DltD_N; pfam04915 1150475011101 DltD central region; Region: DltD_M; pfam04918 1150475011102 DltD C-terminal region; Region: DltD_C; pfam04914 1150475011103 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1150475011104 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1150475011105 homodimer interface [polypeptide binding]; other site 1150475011106 substrate-cofactor binding pocket; other site 1150475011107 catalytic residue [active] 1150475011108 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1150475011109 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1150475011110 NAD binding site [chemical binding]; other site 1150475011111 sugar binding site [chemical binding]; other site 1150475011112 divalent metal binding site [ion binding]; other site 1150475011113 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1150475011114 dimer interface [polypeptide binding]; other site 1150475011115 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1150475011116 methionine cluster; other site 1150475011117 active site 1150475011118 phosphorylation site [posttranslational modification] 1150475011119 metal binding site [ion binding]; metal-binding site 1150475011120 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1150475011121 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1150475011122 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1150475011123 active site 1150475011124 P-loop; other site 1150475011125 phosphorylation site [posttranslational modification] 1150475011126 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1150475011127 HTH domain; Region: HTH_11; pfam08279 1150475011128 Mga helix-turn-helix domain; Region: Mga; pfam05043 1150475011129 PRD domain; Region: PRD; pfam00874 1150475011130 PRD domain; Region: PRD; pfam00874 1150475011131 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1150475011132 active site 1150475011133 P-loop; other site 1150475011134 phosphorylation site [posttranslational modification] 1150475011135 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1150475011136 active site 1150475011137 phosphorylation site [posttranslational modification] 1150475011138 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1150475011139 active site 1150475011140 DNA binding site [nucleotide binding] 1150475011141 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1150475011142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475011143 ABC-ATPase subunit interface; other site 1150475011144 dimer interface [polypeptide binding]; other site 1150475011145 putative PBP binding regions; other site 1150475011146 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1150475011147 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1150475011148 ABC-ATPase subunit interface; other site 1150475011149 dimer interface [polypeptide binding]; other site 1150475011150 putative PBP binding regions; other site 1150475011151 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1150475011152 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1150475011153 intersubunit interface [polypeptide binding]; other site 1150475011154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475011155 dimerization interface [polypeptide binding]; other site 1150475011156 putative DNA binding site [nucleotide binding]; other site 1150475011157 putative Zn2+ binding site [ion binding]; other site 1150475011158 arsenical pump membrane protein; Provisional; Region: PRK15445 1150475011159 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1150475011160 transmembrane helices; other site 1150475011161 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1150475011162 active site 1150475011163 P-loop; other site 1150475011164 phosphorylation site [posttranslational modification] 1150475011165 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1150475011166 active site 1150475011167 methionine cluster; other site 1150475011168 phosphorylation site [posttranslational modification] 1150475011169 metal binding site [ion binding]; metal-binding site 1150475011170 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1150475011171 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1150475011172 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1150475011173 beta-galactosidase; Region: BGL; TIGR03356 1150475011174 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1150475011175 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1150475011176 nucleotide binding site [chemical binding]; other site 1150475011177 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1150475011178 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1150475011179 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1150475011180 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1150475011181 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1150475011182 tetramer interface [polypeptide binding]; other site 1150475011183 heme binding pocket [chemical binding]; other site 1150475011184 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1150475011185 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1150475011186 active site 1150475011187 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1150475011188 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1150475011189 Na binding site [ion binding]; other site 1150475011190 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1150475011191 putative substrate binding site [chemical binding]; other site 1150475011192 putative ATP binding site [chemical binding]; other site 1150475011193 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1150475011194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475011195 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1150475011196 Walker A/P-loop; other site 1150475011197 ATP binding site [chemical binding]; other site 1150475011198 Q-loop/lid; other site 1150475011199 ABC transporter signature motif; other site 1150475011200 Walker B; other site 1150475011201 D-loop; other site 1150475011202 H-loop/switch region; other site 1150475011203 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1150475011204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1150475011205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475011206 ATP binding site [chemical binding]; other site 1150475011207 Q-loop/lid; other site 1150475011208 ABC transporter signature motif; other site 1150475011209 Walker B; other site 1150475011210 D-loop; other site 1150475011211 H-loop/switch region; other site 1150475011212 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1150475011213 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1150475011214 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1150475011215 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1150475011216 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1150475011217 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1150475011218 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1150475011219 putative active site [active] 1150475011220 putative metal binding site [ion binding]; other site 1150475011221 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1150475011222 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1150475011223 Walker A/P-loop; other site 1150475011224 ATP binding site [chemical binding]; other site 1150475011225 Q-loop/lid; other site 1150475011226 ABC transporter signature motif; other site 1150475011227 Walker B; other site 1150475011228 D-loop; other site 1150475011229 H-loop/switch region; other site 1150475011230 TOBE domain; Region: TOBE; pfam03459 1150475011231 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1150475011232 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1150475011233 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1150475011234 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475011235 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1150475011236 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1150475011237 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1150475011238 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1150475011239 UDP-glucose 4-epimerase; Region: PLN02240 1150475011240 NAD binding site [chemical binding]; other site 1150475011241 homodimer interface [polypeptide binding]; other site 1150475011242 active site 1150475011243 substrate binding site [chemical binding]; other site 1150475011244 peptidase T; Region: peptidase-T; TIGR01882 1150475011245 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1150475011246 metal binding site [ion binding]; metal-binding site 1150475011247 dimer interface [polypeptide binding]; other site 1150475011248 Tubby C 2; Region: Tub_2; cl02043 1150475011249 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1150475011250 substrate binding site [chemical binding]; other site 1150475011251 THF binding site; other site 1150475011252 zinc-binding site [ion binding]; other site 1150475011253 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1150475011254 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1150475011255 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1150475011256 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1150475011257 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1150475011258 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1150475011259 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1150475011260 hydroperoxidase II; Provisional; Region: katE; PRK11249 1150475011261 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1150475011262 tetramer interface [polypeptide binding]; other site 1150475011263 heme binding pocket [chemical binding]; other site 1150475011264 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1150475011265 domain interactions; other site 1150475011266 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1150475011267 Citrate transporter; Region: CitMHS; pfam03600 1150475011268 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1150475011269 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1150475011270 active site 1150475011271 active site 1150475011272 catalytic residues [active] 1150475011273 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1150475011274 CAT RNA binding domain; Region: CAT_RBD; smart01061 1150475011275 PRD domain; Region: PRD; pfam00874 1150475011276 PRD domain; Region: PRD; pfam00874 1150475011277 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1150475011278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475011279 putative substrate translocation pore; other site 1150475011280 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1150475011281 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1150475011282 ATP binding site [chemical binding]; other site 1150475011283 Mg++ binding site [ion binding]; other site 1150475011284 motif III; other site 1150475011285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1150475011286 nucleotide binding region [chemical binding]; other site 1150475011287 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1150475011288 RNA binding site [nucleotide binding]; other site 1150475011289 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1150475011290 YxiJ-like protein; Region: YxiJ; pfam14176 1150475011291 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 1150475011292 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 1150475011293 RHS Repeat; Region: RHS_repeat; pfam05593 1150475011294 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1150475011295 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1150475011296 RHS Repeat; Region: RHS_repeat; pfam05593 1150475011297 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1150475011298 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1150475011299 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1150475011300 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1150475011301 Amb_all domain; Region: Amb_all; smart00656 1150475011302 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1150475011303 EamA-like transporter family; Region: EamA; pfam00892 1150475011304 EamA-like transporter family; Region: EamA; pfam00892 1150475011305 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1150475011306 Ligand Binding Site [chemical binding]; other site 1150475011307 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1150475011308 beta-galactosidase; Region: BGL; TIGR03356 1150475011309 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1150475011310 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1150475011311 active site turn [active] 1150475011312 phosphorylation site [posttranslational modification] 1150475011313 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1150475011314 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1150475011315 HPr interaction site; other site 1150475011316 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1150475011317 active site 1150475011318 phosphorylation site [posttranslational modification] 1150475011319 Protein of unknown function DUF262; Region: DUF262; pfam03235 1150475011320 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 1150475011321 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1150475011322 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1150475011323 substrate binding site [chemical binding]; other site 1150475011324 active site 1150475011325 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1150475011326 hexamer interface [polypeptide binding]; other site 1150475011327 RNA binding site [nucleotide binding]; other site 1150475011328 Histidine-zinc binding site [chemical binding]; other site 1150475011329 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1150475011330 active sites [active] 1150475011331 tetramer interface [polypeptide binding]; other site 1150475011332 urocanate hydratase; Provisional; Region: PRK05414 1150475011333 imidazolonepropionase; Validated; Region: PRK09356 1150475011334 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1150475011335 active site 1150475011336 Agmatinase-like family; Region: Agmatinase-like; cd09990 1150475011337 agmatinase; Region: agmatinase; TIGR01230 1150475011338 active site 1150475011339 oligomer interface [polypeptide binding]; other site 1150475011340 Mn binding site [ion binding]; other site 1150475011341 S-methylmethionine transporter; Provisional; Region: PRK11387 1150475011342 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1150475011343 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1150475011344 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1150475011345 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1150475011346 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1150475011347 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1150475011348 Nucleoside recognition; Region: Gate; pfam07670 1150475011349 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1150475011350 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1150475011351 intersubunit interface [polypeptide binding]; other site 1150475011352 active site 1150475011353 catalytic residue [active] 1150475011354 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1150475011355 MarR family; Region: MarR_2; pfam12802 1150475011356 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1150475011357 sugar phosphate phosphatase; Provisional; Region: PRK10513 1150475011358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475011359 active site 1150475011360 motif I; other site 1150475011361 motif II; other site 1150475011362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1150475011363 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1150475011364 SlyX; Region: SlyX; cl01090 1150475011365 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1150475011366 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1150475011367 putative ligand binding residues [chemical binding]; other site 1150475011368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1150475011369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1150475011370 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1150475011371 Walker A/P-loop; other site 1150475011372 ATP binding site [chemical binding]; other site 1150475011373 Q-loop/lid; other site 1150475011374 ABC transporter signature motif; other site 1150475011375 Walker B; other site 1150475011376 D-loop; other site 1150475011377 H-loop/switch region; other site 1150475011378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475011379 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1150475011380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475011381 ATP binding site [chemical binding]; other site 1150475011382 Mg2+ binding site [ion binding]; other site 1150475011383 G-X-G motif; other site 1150475011384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475011385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475011386 active site 1150475011387 phosphorylation site [posttranslational modification] 1150475011388 intermolecular recognition site; other site 1150475011389 dimerization interface [polypeptide binding]; other site 1150475011390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475011391 DNA binding site [nucleotide binding] 1150475011392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475011393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475011394 dimer interface [polypeptide binding]; other site 1150475011395 phosphorylation site [posttranslational modification] 1150475011396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475011397 ATP binding site [chemical binding]; other site 1150475011398 Mg2+ binding site [ion binding]; other site 1150475011399 G-X-G motif; other site 1150475011400 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475011401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475011402 active site 1150475011403 phosphorylation site [posttranslational modification] 1150475011404 intermolecular recognition site; other site 1150475011405 dimerization interface [polypeptide binding]; other site 1150475011406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475011407 DNA binding site [nucleotide binding] 1150475011408 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1150475011409 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1150475011410 Walker A/P-loop; other site 1150475011411 ATP binding site [chemical binding]; other site 1150475011412 Q-loop/lid; other site 1150475011413 ABC transporter signature motif; other site 1150475011414 Walker B; other site 1150475011415 D-loop; other site 1150475011416 H-loop/switch region; other site 1150475011417 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1150475011418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1150475011419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1150475011420 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1150475011421 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1150475011422 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1150475011423 intersubunit interface [polypeptide binding]; other site 1150475011424 active site 1150475011425 zinc binding site [ion binding]; other site 1150475011426 Na+ binding site [ion binding]; other site 1150475011427 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1150475011428 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1150475011429 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1150475011430 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1150475011431 DNA interaction; other site 1150475011432 Metal-binding active site; metal-binding site 1150475011433 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1150475011434 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1150475011435 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1150475011436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475011437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475011438 putative substrate translocation pore; other site 1150475011439 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1150475011440 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1150475011441 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1150475011442 PYR/PP interface [polypeptide binding]; other site 1150475011443 dimer interface [polypeptide binding]; other site 1150475011444 TPP binding site [chemical binding]; other site 1150475011445 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1150475011446 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1150475011447 TPP-binding site; other site 1150475011448 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1150475011449 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1150475011450 substrate binding site [chemical binding]; other site 1150475011451 ATP binding site [chemical binding]; other site 1150475011452 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1150475011453 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1150475011454 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1150475011455 tetrameric interface [polypeptide binding]; other site 1150475011456 NAD binding site [chemical binding]; other site 1150475011457 catalytic residues [active] 1150475011458 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1150475011459 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1150475011460 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1150475011461 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475011462 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475011463 active site 1150475011464 catalytic tetrad [active] 1150475011465 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1150475011466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475011467 putative substrate translocation pore; other site 1150475011468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475011469 heat shock protein 90; Provisional; Region: PRK05218 1150475011470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475011471 ATP binding site [chemical binding]; other site 1150475011472 Mg2+ binding site [ion binding]; other site 1150475011473 G-X-G motif; other site 1150475011474 short chain dehydrogenase; Validated; Region: PRK08589 1150475011475 classical (c) SDRs; Region: SDR_c; cd05233 1150475011476 NAD(P) binding site [chemical binding]; other site 1150475011477 active site 1150475011478 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1150475011479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475011480 active site 1150475011481 phosphorylation site [posttranslational modification] 1150475011482 intermolecular recognition site; other site 1150475011483 dimerization interface [polypeptide binding]; other site 1150475011484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1150475011485 DNA binding residues [nucleotide binding] 1150475011486 dimerization interface [polypeptide binding]; other site 1150475011487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1150475011488 Histidine kinase; Region: HisKA_3; pfam07730 1150475011489 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1150475011490 ATP binding site [chemical binding]; other site 1150475011491 Mg2+ binding site [ion binding]; other site 1150475011492 G-X-G motif; other site 1150475011493 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1150475011494 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1150475011495 putative di-iron ligands [ion binding]; other site 1150475011496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475011497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475011498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1150475011499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1150475011500 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1150475011501 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1150475011502 NAD(P) binding site [chemical binding]; other site 1150475011503 catalytic residues [active] 1150475011504 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1150475011505 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1150475011506 Trp docking motif [polypeptide binding]; other site 1150475011507 active site 1150475011508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475011509 putative DNA binding site [nucleotide binding]; other site 1150475011510 dimerization interface [polypeptide binding]; other site 1150475011511 putative Zn2+ binding site [ion binding]; other site 1150475011512 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1150475011513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475011514 putative substrate translocation pore; other site 1150475011515 RDD family; Region: RDD; pfam06271 1150475011516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475011517 active site 1150475011518 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1150475011519 peroxiredoxin; Region: AhpC; TIGR03137 1150475011520 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1150475011521 dimer interface [polypeptide binding]; other site 1150475011522 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1150475011523 catalytic triad [active] 1150475011524 peroxidatic and resolving cysteines [active] 1150475011525 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1150475011526 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1150475011527 catalytic residue [active] 1150475011528 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1150475011529 catalytic residues [active] 1150475011530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1150475011531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1150475011532 Fic family protein [Function unknown]; Region: COG3177 1150475011533 Fic/DOC family; Region: Fic; pfam02661 1150475011534 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1150475011535 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1150475011536 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1150475011537 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1150475011538 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1150475011539 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1150475011540 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1150475011541 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1150475011542 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1150475011543 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1150475011544 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1150475011545 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1150475011546 Ligand binding site; other site 1150475011547 metal-binding site 1150475011548 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1150475011549 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1150475011550 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1150475011551 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1150475011552 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1150475011553 active site 1150475011554 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1150475011555 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1150475011556 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1150475011557 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1150475011558 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1150475011559 active site 1150475011560 catalytic tetrad [active] 1150475011561 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1150475011562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475011563 Coenzyme A binding pocket [chemical binding]; other site 1150475011564 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475011565 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1150475011566 Arginase family; Region: Arginase; cd09989 1150475011567 agmatinase; Region: agmatinase; TIGR01230 1150475011568 active site 1150475011569 Mn binding site [ion binding]; other site 1150475011570 oligomer interface [polypeptide binding]; other site 1150475011571 S-methylmethionine transporter; Provisional; Region: PRK11387 1150475011572 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1150475011573 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1150475011574 inhibitor-cofactor binding pocket; inhibition site 1150475011575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475011576 catalytic residue [active] 1150475011577 Predicted integral membrane protein [Function unknown]; Region: COG5658 1150475011578 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1150475011579 SdpI/YhfL protein family; Region: SdpI; pfam13630 1150475011580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475011581 dimerization interface [polypeptide binding]; other site 1150475011582 putative DNA binding site [nucleotide binding]; other site 1150475011583 putative Zn2+ binding site [ion binding]; other site 1150475011584 PAS domain; Region: PAS_9; pfam13426 1150475011585 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1150475011586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1150475011587 Walker A motif; other site 1150475011588 ATP binding site [chemical binding]; other site 1150475011589 Walker B motif; other site 1150475011590 arginine finger; other site 1150475011591 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1150475011592 Cupin-like domain; Region: Cupin_8; pfam13621 1150475011593 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1150475011594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1150475011595 Walker A/P-loop; other site 1150475011596 ATP binding site [chemical binding]; other site 1150475011597 Q-loop/lid; other site 1150475011598 ABC transporter signature motif; other site 1150475011599 Walker B; other site 1150475011600 D-loop; other site 1150475011601 H-loop/switch region; other site 1150475011602 ABC transporter; Region: ABC_tran_2; pfam12848 1150475011603 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1150475011604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475011605 putative substrate translocation pore; other site 1150475011606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1150475011607 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1150475011608 hypothetical protein; Provisional; Region: PRK08328 1150475011609 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1150475011610 ATP binding site [chemical binding]; other site 1150475011611 substrate interface [chemical binding]; other site 1150475011612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1150475011613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475011614 dimerization interface [polypeptide binding]; other site 1150475011615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475011616 dimer interface [polypeptide binding]; other site 1150475011617 phosphorylation site [posttranslational modification] 1150475011618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475011619 ATP binding site [chemical binding]; other site 1150475011620 Mg2+ binding site [ion binding]; other site 1150475011621 G-X-G motif; other site 1150475011622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1150475011623 DNA binding site [nucleotide binding] 1150475011624 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1150475011625 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1150475011626 protein binding site [polypeptide binding]; other site 1150475011627 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1150475011628 YycH protein; Region: YycI; cl02015 1150475011629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1150475011630 YycH protein; Region: YycH; pfam07435 1150475011631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1150475011632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1150475011633 dimerization interface [polypeptide binding]; other site 1150475011634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1150475011635 putative active site [active] 1150475011636 heme pocket [chemical binding]; other site 1150475011637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1150475011638 dimer interface [polypeptide binding]; other site 1150475011639 phosphorylation site [posttranslational modification] 1150475011640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1150475011641 ATP binding site [chemical binding]; other site 1150475011642 Mg2+ binding site [ion binding]; other site 1150475011643 G-X-G motif; other site 1150475011644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1150475011645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1150475011646 active site 1150475011647 phosphorylation site [posttranslational modification] 1150475011648 intermolecular recognition site; other site 1150475011649 dimerization interface [polypeptide binding]; other site 1150475011650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1150475011651 DNA binding site [nucleotide binding] 1150475011652 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1150475011653 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1150475011654 GDP-binding site [chemical binding]; other site 1150475011655 ACT binding site; other site 1150475011656 IMP binding site; other site 1150475011657 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475011658 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1150475011659 active site 1150475011660 replicative DNA helicase; Provisional; Region: PRK05748 1150475011661 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1150475011662 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1150475011663 Walker A motif; other site 1150475011664 ATP binding site [chemical binding]; other site 1150475011665 Walker B motif; other site 1150475011666 DNA binding loops [nucleotide binding] 1150475011667 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1150475011668 YycC-like protein; Region: YycC; pfam14174 1150475011669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1150475011670 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1150475011671 Phosphotransferase enzyme family; Region: APH; pfam01636 1150475011672 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1150475011673 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1150475011674 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1150475011675 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1150475011676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1150475011677 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1150475011678 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1150475011679 active site 1150475011680 substrate binding site [chemical binding]; other site 1150475011681 ATP binding site [chemical binding]; other site 1150475011682 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1150475011683 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1150475011684 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1150475011685 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1150475011686 diguanylate cyclase; Region: GGDEF; smart00267 1150475011687 DHH family; Region: DHH; pfam01368 1150475011688 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1150475011689 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1150475011690 Predicted transcriptional regulators [Transcription]; Region: COG1733 1150475011691 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1150475011692 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1150475011693 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1150475011694 DHHA2 domain; Region: DHHA2; pfam02833 1150475011695 EamA-like transporter family; Region: EamA; pfam00892 1150475011696 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1150475011697 EamA-like transporter family; Region: EamA; pfam00892 1150475011698 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1150475011699 active site 1150475011700 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1150475011701 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1150475011702 substrate binding [chemical binding]; other site 1150475011703 active site 1150475011704 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1150475011705 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1150475011706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475011707 DNA-binding site [nucleotide binding]; DNA binding site 1150475011708 FCD domain; Region: FCD; pfam07729 1150475011709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1150475011710 DinB superfamily; Region: DinB_2; pfam12867 1150475011711 H+ Antiporter protein; Region: 2A0121; TIGR00900 1150475011712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475011713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475011714 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1150475011715 dimerization interface [polypeptide binding]; other site 1150475011716 LysE type translocator; Region: LysE; cl00565 1150475011717 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1150475011718 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1150475011719 dimer interface [polypeptide binding]; other site 1150475011720 FMN binding site [chemical binding]; other site 1150475011721 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475011722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1150475011723 putative DNA binding site [nucleotide binding]; other site 1150475011724 putative Zn2+ binding site [ion binding]; other site 1150475011725 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475011726 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1150475011727 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1150475011728 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1150475011729 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1150475011730 MarR family; Region: MarR; pfam01047 1150475011731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475011732 Coenzyme A binding pocket [chemical binding]; other site 1150475011733 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1150475011734 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1150475011735 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1150475011736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1150475011737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1150475011738 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1150475011739 putative dimerization interface [polypeptide binding]; other site 1150475011740 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1150475011741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1150475011742 NAD(P) binding site [chemical binding]; other site 1150475011743 active site 1150475011744 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1150475011745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1150475011746 DNA-binding site [nucleotide binding]; DNA binding site 1150475011747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1150475011748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1150475011749 homodimer interface [polypeptide binding]; other site 1150475011750 catalytic residue [active] 1150475011751 EamA-like transporter family; Region: EamA; pfam00892 1150475011752 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1150475011753 EamA-like transporter family; Region: EamA; pfam00892 1150475011754 MepB protein; Region: MepB; pfam08877 1150475011755 Evidence 5 : No homology to any previously reported sequences 1150475011756 AAA domain; Region: AAA_17; pfam13207 1150475011757 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1150475011758 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1150475011759 catalytic residues [active] 1150475011760 catalytic nucleophile [active] 1150475011761 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1150475011762 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1150475011763 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1150475011764 CAAX protease self-immunity; Region: Abi; pfam02517 1150475011765 benzoate transport; Region: 2A0115; TIGR00895 1150475011766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475011767 putative substrate translocation pore; other site 1150475011768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1150475011769 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1150475011770 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1150475011771 putative metal binding site [ion binding]; other site 1150475011772 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1150475011773 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1150475011774 DNA binding site [nucleotide binding] 1150475011775 domain linker motif; other site 1150475011776 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1150475011777 putative dimerization interface [polypeptide binding]; other site 1150475011778 putative ligand binding site [chemical binding]; other site 1150475011779 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1150475011780 active site 1150475011781 putative catalytic site [active] 1150475011782 DNA binding site [nucleotide binding] 1150475011783 putative phosphate binding site [ion binding]; other site 1150475011784 metal binding site A [ion binding]; metal-binding site 1150475011785 AP binding site [nucleotide binding]; other site 1150475011786 metal binding site B [ion binding]; metal-binding site 1150475011787 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1150475011788 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1150475011789 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1150475011790 DNA binding site [nucleotide binding] 1150475011791 active site 1150475011792 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1150475011793 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1150475011794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1150475011795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1150475011796 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1150475011797 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1150475011798 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1150475011799 dimer interface [polypeptide binding]; other site 1150475011800 ssDNA binding site [nucleotide binding]; other site 1150475011801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1150475011802 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1150475011803 GTP-binding protein YchF; Reviewed; Region: PRK09601 1150475011804 YchF GTPase; Region: YchF; cd01900 1150475011805 G1 box; other site 1150475011806 GTP/Mg2+ binding site [chemical binding]; other site 1150475011807 Switch I region; other site 1150475011808 G2 box; other site 1150475011809 Switch II region; other site 1150475011810 G3 box; other site 1150475011811 G4 box; other site 1150475011812 G5 box; other site 1150475011813 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1150475011814 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1150475011815 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1150475011816 putative [4Fe-4S] binding site [ion binding]; other site 1150475011817 putative molybdopterin cofactor binding site [chemical binding]; other site 1150475011818 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1150475011819 molybdopterin cofactor binding site; other site 1150475011820 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1150475011821 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1150475011822 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1150475011823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1150475011824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1150475011825 Coenzyme A binding pocket [chemical binding]; other site 1150475011826 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1150475011827 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1150475011828 ParB-like nuclease domain; Region: ParB; smart00470 1150475011829 KorB domain; Region: KorB; pfam08535 1150475011830 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1150475011831 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1150475011832 P-loop; other site 1150475011833 Magnesium ion binding site [ion binding]; other site 1150475011834 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1150475011835 Magnesium ion binding site [ion binding]; other site 1150475011836 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1150475011837 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1150475011838 ParB-like nuclease domain; Region: ParB; smart00470 1150475011839 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1150475011840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1150475011841 S-adenosylmethionine binding site [chemical binding]; other site 1150475011842 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1150475011843 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1150475011844 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1150475011845 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1150475011846 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1150475011847 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1150475011848 G1 box; other site 1150475011849 GTP/Mg2+ binding site [chemical binding]; other site 1150475011850 Switch I region; other site 1150475011851 G2 box; other site 1150475011852 Switch II region; other site 1150475011853 G3 box; other site 1150475011854 G4 box; other site 1150475011855 G5 box; other site 1150475011856 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1150475011857 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1150475011858 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1150475011859 G-X-X-G motif; other site 1150475011860 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1150475011861 RxxxH motif; other site 1150475011862 OxaA-like protein precursor; Validated; Region: PRK02944 1150475011863 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1150475011864 ribonuclease P; Reviewed; Region: rnpA; PRK00499