-- dump date 20140618_211643 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1155777000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1155777000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1155777000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777000004 Walker A motif; other site 1155777000005 ATP binding site [chemical binding]; other site 1155777000006 Walker B motif; other site 1155777000007 arginine finger; other site 1155777000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1155777000009 DnaA box-binding interface [nucleotide binding]; other site 1155777000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1155777000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1155777000012 putative DNA binding surface [nucleotide binding]; other site 1155777000013 dimer interface [polypeptide binding]; other site 1155777000014 beta-clamp/clamp loader binding surface; other site 1155777000015 beta-clamp/translesion DNA polymerase binding surface; other site 1155777000016 S4 domain; Region: S4_2; pfam13275 1155777000017 recombination protein F; Reviewed; Region: recF; PRK00064 1155777000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1155777000019 Walker A/P-loop; other site 1155777000020 ATP binding site [chemical binding]; other site 1155777000021 Q-loop/lid; other site 1155777000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777000023 ABC transporter signature motif; other site 1155777000024 Walker B; other site 1155777000025 D-loop; other site 1155777000026 H-loop/switch region; other site 1155777000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1155777000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777000029 ATP binding site [chemical binding]; other site 1155777000030 Mg2+ binding site [ion binding]; other site 1155777000031 G-X-G motif; other site 1155777000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1155777000033 anchoring element; other site 1155777000034 dimer interface [polypeptide binding]; other site 1155777000035 ATP binding site [chemical binding]; other site 1155777000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1155777000037 active site 1155777000038 putative metal-binding site [ion binding]; other site 1155777000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1155777000040 DNA gyrase subunit A; Validated; Region: PRK05560 1155777000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1155777000042 CAP-like domain; other site 1155777000043 active site 1155777000044 primary dimer interface [polypeptide binding]; other site 1155777000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777000051 YaaC-like Protein; Region: YaaC; pfam14175 1155777000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1155777000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1155777000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1155777000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1155777000056 active site 1155777000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1155777000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1155777000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1155777000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1155777000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1155777000062 active site 1155777000063 multimer interface [polypeptide binding]; other site 1155777000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1155777000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1155777000066 predicted active site [active] 1155777000067 catalytic triad [active] 1155777000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 1155777000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1155777000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1155777000071 dimer interface [polypeptide binding]; other site 1155777000072 active site 1155777000073 motif 1; other site 1155777000074 motif 2; other site 1155777000075 motif 3; other site 1155777000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1155777000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1155777000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1155777000079 Substrate-binding site [chemical binding]; other site 1155777000080 Substrate specificity [chemical binding]; other site 1155777000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1155777000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1155777000083 Substrate-binding site [chemical binding]; other site 1155777000084 Substrate specificity [chemical binding]; other site 1155777000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1155777000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1155777000089 active site 1155777000090 Isochorismatase family; Region: Isochorismatase; pfam00857 1155777000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155777000092 catalytic triad [active] 1155777000093 conserved cis-peptide bond; other site 1155777000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1155777000095 nucleoside/Zn binding site; other site 1155777000096 dimer interface [polypeptide binding]; other site 1155777000097 catalytic motif [active] 1155777000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1155777000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777000100 Walker A motif; other site 1155777000101 ATP binding site [chemical binding]; other site 1155777000102 Walker B motif; other site 1155777000103 arginine finger; other site 1155777000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1155777000105 hypothetical protein; Validated; Region: PRK00153 1155777000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 1155777000107 RecR protein; Region: RecR; pfam02132 1155777000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1155777000109 putative active site [active] 1155777000110 putative metal-binding site [ion binding]; other site 1155777000111 tetramer interface [polypeptide binding]; other site 1155777000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1155777000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 1155777000114 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1155777000115 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1155777000116 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1155777000117 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1155777000118 homodimer interface [polypeptide binding]; other site 1155777000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777000120 catalytic residue [active] 1155777000121 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1155777000122 thymidylate kinase; Validated; Region: tmk; PRK00698 1155777000123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1155777000124 TMP-binding site; other site 1155777000125 ATP-binding site [chemical binding]; other site 1155777000126 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1155777000127 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1155777000128 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1155777000129 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1155777000130 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1155777000131 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1155777000132 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1155777000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777000134 S-adenosylmethionine binding site [chemical binding]; other site 1155777000135 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1155777000136 GIY-YIG motif/motif A; other site 1155777000137 putative active site [active] 1155777000138 putative metal binding site [ion binding]; other site 1155777000139 Predicted methyltransferases [General function prediction only]; Region: COG0313 1155777000140 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1155777000141 putative SAM binding site [chemical binding]; other site 1155777000142 putative homodimer interface [polypeptide binding]; other site 1155777000143 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1155777000144 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1155777000145 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1155777000146 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1155777000147 active site 1155777000148 HIGH motif; other site 1155777000149 KMSKS motif; other site 1155777000150 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1155777000151 tRNA binding surface [nucleotide binding]; other site 1155777000152 anticodon binding site; other site 1155777000153 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1155777000154 dimer interface [polypeptide binding]; other site 1155777000155 putative tRNA-binding site [nucleotide binding]; other site 1155777000156 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1155777000157 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1155777000158 active site 1155777000159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1155777000160 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1155777000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1155777000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1155777000163 G5 domain; Region: G5; pfam07501 1155777000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1155777000165 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1155777000166 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1155777000167 putative active site [active] 1155777000168 putative metal binding site [ion binding]; other site 1155777000169 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1155777000170 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1155777000171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777000172 S-adenosylmethionine binding site [chemical binding]; other site 1155777000173 YabG peptidase U57; Region: Peptidase_U57; pfam05582 1155777000174 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1155777000175 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1155777000176 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1155777000177 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155777000178 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155777000179 pur operon repressor; Provisional; Region: PRK09213 1155777000180 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1155777000181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777000182 active site 1155777000183 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1155777000184 homotrimer interaction site [polypeptide binding]; other site 1155777000185 putative active site [active] 1155777000186 regulatory protein SpoVG; Reviewed; Region: PRK13259 1155777000187 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1155777000188 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1155777000189 Substrate binding site; other site 1155777000190 Mg++ binding site; other site 1155777000191 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1155777000192 active site 1155777000193 substrate binding site [chemical binding]; other site 1155777000194 CoA binding site [chemical binding]; other site 1155777000195 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1155777000196 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1155777000197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777000198 active site 1155777000199 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1155777000200 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1155777000201 5S rRNA interface [nucleotide binding]; other site 1155777000202 CTC domain interface [polypeptide binding]; other site 1155777000203 L16 interface [polypeptide binding]; other site 1155777000204 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1155777000205 putative active site [active] 1155777000206 catalytic residue [active] 1155777000207 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1155777000208 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1155777000209 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1155777000210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777000211 ATP binding site [chemical binding]; other site 1155777000212 putative Mg++ binding site [ion binding]; other site 1155777000213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777000214 nucleotide binding region [chemical binding]; other site 1155777000215 ATP-binding site [chemical binding]; other site 1155777000216 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1155777000217 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1155777000218 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1155777000219 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155777000220 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155777000221 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1155777000222 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1155777000223 putative SAM binding site [chemical binding]; other site 1155777000224 putative homodimer interface [polypeptide binding]; other site 1155777000225 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1155777000226 homodimer interface [polypeptide binding]; other site 1155777000227 metal binding site [ion binding]; metal-binding site 1155777000228 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1155777000229 homodimer interface [polypeptide binding]; other site 1155777000230 active site 1155777000231 putative chemical substrate binding site [chemical binding]; other site 1155777000232 metal binding site [ion binding]; metal-binding site 1155777000233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777000234 RNA binding surface [nucleotide binding]; other site 1155777000235 sporulation protein YabP; Region: spore_yabP; TIGR02892 1155777000236 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1155777000237 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1155777000238 Septum formation initiator; Region: DivIC; pfam04977 1155777000239 hypothetical protein; Provisional; Region: PRK08582 1155777000240 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155777000241 RNA binding site [nucleotide binding]; other site 1155777000242 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1155777000243 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1155777000244 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1155777000245 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1155777000246 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1155777000247 metal ion-dependent adhesion site (MIDAS); other site 1155777000248 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1155777000249 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1155777000250 active site 1155777000251 ATP binding site [chemical binding]; other site 1155777000252 substrate binding site [chemical binding]; other site 1155777000253 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1155777000254 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1155777000255 Ligand Binding Site [chemical binding]; other site 1155777000256 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1155777000257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777000258 active site 1155777000259 FtsH Extracellular; Region: FtsH_ext; pfam06480 1155777000260 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1155777000261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777000262 Walker A motif; other site 1155777000263 ATP binding site [chemical binding]; other site 1155777000264 Walker B motif; other site 1155777000265 arginine finger; other site 1155777000266 Peptidase family M41; Region: Peptidase_M41; pfam01434 1155777000267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155777000268 nucleotide binding site [chemical binding]; other site 1155777000269 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1155777000270 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1155777000271 dimerization interface [polypeptide binding]; other site 1155777000272 domain crossover interface; other site 1155777000273 redox-dependent activation switch; other site 1155777000274 SurA N-terminal domain; Region: SurA_N_3; cl07813 1155777000275 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1155777000276 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1155777000277 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1155777000278 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155777000279 dimer interface [polypeptide binding]; other site 1155777000280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777000281 catalytic residue [active] 1155777000282 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1155777000283 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1155777000284 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1155777000285 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1155777000286 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1155777000287 glutamine binding [chemical binding]; other site 1155777000288 catalytic triad [active] 1155777000289 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1155777000290 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1155777000291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777000292 catalytic residue [active] 1155777000293 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1155777000294 dihydropteroate synthase; Region: DHPS; TIGR01496 1155777000295 substrate binding pocket [chemical binding]; other site 1155777000296 dimer interface [polypeptide binding]; other site 1155777000297 inhibitor binding site; inhibition site 1155777000298 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1155777000299 homooctamer interface [polypeptide binding]; other site 1155777000300 active site 1155777000301 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1155777000302 catalytic center binding site [active] 1155777000303 ATP binding site [chemical binding]; other site 1155777000304 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1155777000305 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1155777000306 FMN binding site [chemical binding]; other site 1155777000307 active site 1155777000308 catalytic residues [active] 1155777000309 substrate binding site [chemical binding]; other site 1155777000310 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1155777000311 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1155777000312 dimer interface [polypeptide binding]; other site 1155777000313 putative anticodon binding site; other site 1155777000314 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1155777000315 motif 1; other site 1155777000316 active site 1155777000317 motif 2; other site 1155777000318 motif 3; other site 1155777000319 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1155777000320 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1155777000321 UvrB/uvrC motif; Region: UVR; pfam02151 1155777000322 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1155777000323 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1155777000324 ADP binding site [chemical binding]; other site 1155777000325 phosphagen binding site; other site 1155777000326 substrate specificity loop; other site 1155777000327 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1155777000328 Clp amino terminal domain; Region: Clp_N; pfam02861 1155777000329 Clp amino terminal domain; Region: Clp_N; pfam02861 1155777000330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777000331 Walker A motif; other site 1155777000332 ATP binding site [chemical binding]; other site 1155777000333 Walker B motif; other site 1155777000334 arginine finger; other site 1155777000335 UvrB/uvrC motif; Region: UVR; pfam02151 1155777000336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777000337 Walker A motif; other site 1155777000338 ATP binding site [chemical binding]; other site 1155777000339 Walker B motif; other site 1155777000340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155777000341 DNA repair protein RadA; Provisional; Region: PRK11823 1155777000342 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1155777000343 Walker A motif/ATP binding site; other site 1155777000344 ATP binding site [chemical binding]; other site 1155777000345 Walker B motif; other site 1155777000346 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1155777000347 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1155777000348 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1155777000349 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1155777000350 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1155777000351 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1155777000352 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1155777000353 putative active site [active] 1155777000354 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1155777000355 substrate binding site; other site 1155777000356 dimer interface; other site 1155777000357 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1155777000358 homotrimer interaction site [polypeptide binding]; other site 1155777000359 zinc binding site [ion binding]; other site 1155777000360 CDP-binding sites; other site 1155777000361 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1155777000362 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1155777000363 HIGH motif; other site 1155777000364 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1155777000365 active site 1155777000366 KMSKS motif; other site 1155777000367 serine O-acetyltransferase; Region: cysE; TIGR01172 1155777000368 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1155777000369 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1155777000370 trimer interface [polypeptide binding]; other site 1155777000371 active site 1155777000372 substrate binding site [chemical binding]; other site 1155777000373 CoA binding site [chemical binding]; other site 1155777000374 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1155777000375 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1155777000376 active site 1155777000377 HIGH motif; other site 1155777000378 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1155777000379 KMSKS motif; other site 1155777000380 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1155777000381 tRNA binding surface [nucleotide binding]; other site 1155777000382 anticodon binding site; other site 1155777000383 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1155777000384 active site 1155777000385 metal binding site [ion binding]; metal-binding site 1155777000386 dimerization interface [polypeptide binding]; other site 1155777000387 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1155777000388 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1155777000389 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1155777000390 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1155777000391 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1155777000392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777000393 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1155777000394 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1155777000395 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1155777000396 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1155777000397 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1155777000398 putative homodimer interface [polypeptide binding]; other site 1155777000399 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1155777000400 heterodimer interface [polypeptide binding]; other site 1155777000401 homodimer interface [polypeptide binding]; other site 1155777000402 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1155777000403 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1155777000404 23S rRNA interface [nucleotide binding]; other site 1155777000405 L7/L12 interface [polypeptide binding]; other site 1155777000406 putative thiostrepton binding site; other site 1155777000407 L25 interface [polypeptide binding]; other site 1155777000408 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1155777000409 mRNA/rRNA interface [nucleotide binding]; other site 1155777000410 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1155777000411 23S rRNA interface [nucleotide binding]; other site 1155777000412 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1155777000413 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1155777000414 core dimer interface [polypeptide binding]; other site 1155777000415 peripheral dimer interface [polypeptide binding]; other site 1155777000416 L10 interface [polypeptide binding]; other site 1155777000417 L11 interface [polypeptide binding]; other site 1155777000418 putative EF-Tu interaction site [polypeptide binding]; other site 1155777000419 putative EF-G interaction site [polypeptide binding]; other site 1155777000420 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1155777000421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777000422 S-adenosylmethionine binding site [chemical binding]; other site 1155777000423 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1155777000424 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1155777000425 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1155777000426 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1155777000427 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1155777000428 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1155777000429 RPB1 interaction site [polypeptide binding]; other site 1155777000430 RPB10 interaction site [polypeptide binding]; other site 1155777000431 RPB11 interaction site [polypeptide binding]; other site 1155777000432 RPB3 interaction site [polypeptide binding]; other site 1155777000433 RPB12 interaction site [polypeptide binding]; other site 1155777000434 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1155777000435 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1155777000436 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1155777000437 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1155777000438 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1155777000439 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1155777000440 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1155777000441 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1155777000442 G-loop; other site 1155777000443 DNA binding site [nucleotide binding] 1155777000444 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1155777000445 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1155777000446 S17 interaction site [polypeptide binding]; other site 1155777000447 S8 interaction site; other site 1155777000448 16S rRNA interaction site [nucleotide binding]; other site 1155777000449 streptomycin interaction site [chemical binding]; other site 1155777000450 23S rRNA interaction site [nucleotide binding]; other site 1155777000451 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1155777000452 30S ribosomal protein S7; Validated; Region: PRK05302 1155777000453 elongation factor G; Reviewed; Region: PRK00007 1155777000454 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1155777000455 G1 box; other site 1155777000456 putative GEF interaction site [polypeptide binding]; other site 1155777000457 GTP/Mg2+ binding site [chemical binding]; other site 1155777000458 Switch I region; other site 1155777000459 G2 box; other site 1155777000460 G3 box; other site 1155777000461 Switch II region; other site 1155777000462 G4 box; other site 1155777000463 G5 box; other site 1155777000464 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1155777000465 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1155777000466 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1155777000467 elongation factor Tu; Reviewed; Region: PRK00049 1155777000468 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1155777000469 G1 box; other site 1155777000470 GEF interaction site [polypeptide binding]; other site 1155777000471 GTP/Mg2+ binding site [chemical binding]; other site 1155777000472 Switch I region; other site 1155777000473 G2 box; other site 1155777000474 G3 box; other site 1155777000475 Switch II region; other site 1155777000476 G4 box; other site 1155777000477 G5 box; other site 1155777000478 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1155777000479 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1155777000480 Antibiotic Binding Site [chemical binding]; other site 1155777000481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1155777000482 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1155777000483 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1155777000484 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1155777000485 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1155777000486 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1155777000487 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1155777000488 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1155777000489 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1155777000490 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1155777000491 putative translocon binding site; other site 1155777000492 protein-rRNA interface [nucleotide binding]; other site 1155777000493 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1155777000494 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1155777000495 G-X-X-G motif; other site 1155777000496 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1155777000497 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1155777000498 23S rRNA interface [nucleotide binding]; other site 1155777000499 5S rRNA interface [nucleotide binding]; other site 1155777000500 putative antibiotic binding site [chemical binding]; other site 1155777000501 L25 interface [polypeptide binding]; other site 1155777000502 L27 interface [polypeptide binding]; other site 1155777000503 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1155777000504 23S rRNA interface [nucleotide binding]; other site 1155777000505 putative translocon interaction site; other site 1155777000506 signal recognition particle (SRP54) interaction site; other site 1155777000507 L23 interface [polypeptide binding]; other site 1155777000508 trigger factor interaction site; other site 1155777000509 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1155777000510 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1155777000511 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1155777000512 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1155777000513 RNA binding site [nucleotide binding]; other site 1155777000514 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1155777000515 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1155777000516 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1155777000517 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1155777000518 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1155777000519 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1155777000520 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1155777000521 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1155777000522 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1155777000523 5S rRNA interface [nucleotide binding]; other site 1155777000524 L27 interface [polypeptide binding]; other site 1155777000525 23S rRNA interface [nucleotide binding]; other site 1155777000526 L5 interface [polypeptide binding]; other site 1155777000527 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1155777000528 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1155777000529 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1155777000530 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1155777000531 23S rRNA binding site [nucleotide binding]; other site 1155777000532 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1155777000533 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1155777000534 SecY translocase; Region: SecY; pfam00344 1155777000535 adenylate kinase; Reviewed; Region: adk; PRK00279 1155777000536 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1155777000537 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1155777000538 AMP-binding site [chemical binding]; other site 1155777000539 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1155777000540 active site 1155777000541 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1155777000542 rRNA binding site [nucleotide binding]; other site 1155777000543 predicted 30S ribosome binding site; other site 1155777000544 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1155777000545 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1155777000546 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1155777000547 30S ribosomal protein S11; Validated; Region: PRK05309 1155777000548 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1155777000549 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1155777000550 alphaNTD homodimer interface [polypeptide binding]; other site 1155777000551 alphaNTD - beta interaction site [polypeptide binding]; other site 1155777000552 alphaNTD - beta' interaction site [polypeptide binding]; other site 1155777000553 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1155777000554 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1155777000555 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1155777000556 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155777000557 Walker A/P-loop; other site 1155777000558 ATP binding site [chemical binding]; other site 1155777000559 Q-loop/lid; other site 1155777000560 ABC transporter signature motif; other site 1155777000561 Walker B; other site 1155777000562 D-loop; other site 1155777000563 H-loop/switch region; other site 1155777000564 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1155777000565 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155777000566 Walker A/P-loop; other site 1155777000567 ATP binding site [chemical binding]; other site 1155777000568 Q-loop/lid; other site 1155777000569 ABC transporter signature motif; other site 1155777000570 Walker B; other site 1155777000571 D-loop; other site 1155777000572 H-loop/switch region; other site 1155777000573 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1155777000574 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1155777000575 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1155777000576 dimerization interface 3.5A [polypeptide binding]; other site 1155777000577 active site 1155777000578 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1155777000579 23S rRNA interface [nucleotide binding]; other site 1155777000580 L3 interface [polypeptide binding]; other site 1155777000581 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1155777000582 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155777000583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777000584 S-adenosylmethionine binding site [chemical binding]; other site 1155777000585 DinB family; Region: DinB; cl17821 1155777000586 DinB superfamily; Region: DinB_2; pfam12867 1155777000587 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1155777000588 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1155777000589 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1155777000590 active site 1155777000591 metal binding site [ion binding]; metal-binding site 1155777000592 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1155777000593 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1155777000594 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1155777000595 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1155777000596 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1155777000597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777000598 putative substrate translocation pore; other site 1155777000599 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1155777000600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777000601 inhibitor-cofactor binding pocket; inhibition site 1155777000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777000603 catalytic residue [active] 1155777000604 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1155777000605 active site 1155777000606 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155777000607 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1155777000608 NAD(P) binding site [chemical binding]; other site 1155777000609 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1155777000610 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1155777000611 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1155777000612 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1155777000613 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1155777000614 Sodium Bile acid symporter family; Region: SBF; cl17470 1155777000615 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1155777000616 Putative esterase; Region: Esterase; pfam00756 1155777000617 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155777000618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777000619 ABC-ATPase subunit interface; other site 1155777000620 dimer interface [polypeptide binding]; other site 1155777000621 putative PBP binding regions; other site 1155777000622 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155777000623 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777000624 ABC-ATPase subunit interface; other site 1155777000625 dimer interface [polypeptide binding]; other site 1155777000626 putative PBP binding regions; other site 1155777000627 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155777000628 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1155777000629 intersubunit interface [polypeptide binding]; other site 1155777000630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777000631 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155777000632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777000633 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1155777000634 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155777000635 intersubunit interface [polypeptide binding]; other site 1155777000636 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1155777000637 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1155777000638 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1155777000639 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1155777000640 putative periplasmic esterase; Provisional; Region: PRK03642 1155777000641 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155777000642 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1155777000643 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155777000644 active site turn [active] 1155777000645 phosphorylation site [posttranslational modification] 1155777000646 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155777000647 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1155777000648 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1155777000649 putative active site [active] 1155777000650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155777000651 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1155777000652 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1155777000653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777000654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777000655 DNA binding residues [nucleotide binding] 1155777000656 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1155777000657 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1155777000658 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1155777000659 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1155777000660 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1155777000661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1155777000662 YbbR-like protein; Region: YbbR; pfam07949 1155777000663 YbbR-like protein; Region: YbbR; pfam07949 1155777000664 YbbR-like protein; Region: YbbR; pfam07949 1155777000665 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1155777000666 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1155777000667 active site 1155777000668 substrate binding site [chemical binding]; other site 1155777000669 metal binding site [ion binding]; metal-binding site 1155777000670 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1155777000671 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1155777000672 glutaminase active site [active] 1155777000673 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1155777000674 dimer interface [polypeptide binding]; other site 1155777000675 active site 1155777000676 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1155777000677 dimer interface [polypeptide binding]; other site 1155777000678 active site 1155777000679 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1155777000680 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155777000681 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155777000682 Walker A/P-loop; other site 1155777000683 ATP binding site [chemical binding]; other site 1155777000684 Q-loop/lid; other site 1155777000685 ABC transporter signature motif; other site 1155777000686 Walker B; other site 1155777000687 D-loop; other site 1155777000688 H-loop/switch region; other site 1155777000689 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1155777000690 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1155777000691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155777000692 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155777000693 active site 1155777000694 catalytic tetrad [active] 1155777000695 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1155777000696 holin-like protein; Validated; Region: PRK01658 1155777000697 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777000698 MarR family; Region: MarR; pfam01047 1155777000699 putative transport protein YifK; Provisional; Region: PRK10746 1155777000700 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1155777000701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777000702 active site 1155777000703 motif I; other site 1155777000704 motif II; other site 1155777000705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155777000706 Histidine kinase; Region: HisKA_3; pfam07730 1155777000707 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155777000708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777000709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777000710 active site 1155777000711 phosphorylation site [posttranslational modification] 1155777000712 intermolecular recognition site; other site 1155777000713 dimerization interface [polypeptide binding]; other site 1155777000714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777000715 DNA binding residues [nucleotide binding] 1155777000716 dimerization interface [polypeptide binding]; other site 1155777000717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777000718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777000719 Walker A/P-loop; other site 1155777000720 ATP binding site [chemical binding]; other site 1155777000721 Q-loop/lid; other site 1155777000722 ABC transporter signature motif; other site 1155777000723 Walker B; other site 1155777000724 D-loop; other site 1155777000725 H-loop/switch region; other site 1155777000726 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1155777000727 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155777000728 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1155777000729 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155777000730 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1155777000731 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1155777000732 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155777000733 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1155777000734 active site 1155777000735 catalytic site [active] 1155777000736 metal binding site [ion binding]; metal-binding site 1155777000737 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1155777000738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777000739 putative substrate translocation pore; other site 1155777000740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777000741 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1155777000742 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1155777000743 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1155777000744 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1155777000745 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155777000746 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1155777000747 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155777000748 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1155777000749 active site 1155777000750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777000751 non-specific DNA binding site [nucleotide binding]; other site 1155777000752 salt bridge; other site 1155777000753 sequence-specific DNA binding site [nucleotide binding]; other site 1155777000754 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1155777000755 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1155777000756 active site 1155777000757 NAD binding site [chemical binding]; other site 1155777000758 metal binding site [ion binding]; metal-binding site 1155777000759 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1155777000760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155777000761 ATP-grasp domain; Region: ATP-grasp; pfam02222 1155777000762 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1155777000763 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1155777000764 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1155777000765 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155777000766 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1155777000767 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1155777000768 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1155777000769 active site residue [active] 1155777000770 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1155777000771 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1155777000772 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1155777000773 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1155777000774 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1155777000775 homodimer interface [polypeptide binding]; other site 1155777000776 substrate-cofactor binding pocket; other site 1155777000777 catalytic residue [active] 1155777000778 S-methylmethionine transporter; Provisional; Region: PRK11387 1155777000779 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1155777000780 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1155777000781 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1155777000782 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1155777000783 glutaminase; Reviewed; Region: PRK12357 1155777000784 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1155777000785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777000786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777000787 ATP binding site [chemical binding]; other site 1155777000788 Mg2+ binding site [ion binding]; other site 1155777000789 G-X-G motif; other site 1155777000790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777000791 Response regulator receiver domain; Region: Response_reg; pfam00072 1155777000792 active site 1155777000793 phosphorylation site [posttranslational modification] 1155777000794 intermolecular recognition site; other site 1155777000795 dimerization interface [polypeptide binding]; other site 1155777000796 YcbB domain; Region: YcbB; pfam08664 1155777000797 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1155777000798 putative active site [active] 1155777000799 putative substrate binding site [chemical binding]; other site 1155777000800 Phosphotransferase enzyme family; Region: APH; pfam01636 1155777000801 ATP binding site [chemical binding]; other site 1155777000802 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1155777000803 dodecamer interface 1 [polypeptide binding]; other site 1155777000804 dodecamer interface 2 [polypeptide binding]; other site 1155777000805 trimer interface [polypeptide binding]; other site 1155777000806 TRAP binding interface [polypeptide binding]; other site 1155777000807 Zn binding site [ion binding]; other site 1155777000808 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1155777000809 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1155777000810 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1155777000811 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1155777000812 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1155777000813 putative active site [active] 1155777000814 putative metal binding site [ion binding]; other site 1155777000815 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1155777000816 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1155777000817 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1155777000818 putative substrate binding pocket [chemical binding]; other site 1155777000819 AC domain interface; other site 1155777000820 catalytic triad [active] 1155777000821 AB domain interface; other site 1155777000822 interchain disulfide; other site 1155777000823 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1155777000824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1155777000825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155777000826 catalytic residue [active] 1155777000827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777000828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777000829 putative substrate translocation pore; other site 1155777000830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777000831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777000832 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1155777000833 active site 1155777000834 homotetramer interface [polypeptide binding]; other site 1155777000835 homodimer interface [polypeptide binding]; other site 1155777000836 Lipase (class 2); Region: Lipase_2; pfam01674 1155777000837 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1155777000838 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1155777000839 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1155777000840 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155777000841 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155777000842 active site 1155777000843 catalytic tetrad [active] 1155777000844 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1155777000845 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1155777000846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777000847 binding surface 1155777000848 TPR motif; other site 1155777000849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1155777000850 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777000851 TPR motif; other site 1155777000852 binding surface 1155777000853 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1155777000854 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1155777000855 NAD binding site [chemical binding]; other site 1155777000856 homodimer interface [polypeptide binding]; other site 1155777000857 active site 1155777000858 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155777000859 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155777000860 Ca binding site [ion binding]; other site 1155777000861 active site 1155777000862 catalytic site [active] 1155777000863 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155777000864 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1155777000865 metal binding site [ion binding]; metal-binding site 1155777000866 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1155777000867 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155777000868 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155777000869 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777000870 ABC-ATPase subunit interface; other site 1155777000871 dimer interface [polypeptide binding]; other site 1155777000872 putative PBP binding regions; other site 1155777000873 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1155777000874 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1155777000875 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1155777000876 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1155777000877 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1155777000878 putative metal binding site [ion binding]; other site 1155777000879 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1155777000880 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1155777000881 putative metal binding site [ion binding]; other site 1155777000882 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1155777000883 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1155777000884 putative metal binding site [ion binding]; other site 1155777000885 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1155777000886 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1155777000887 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1155777000888 benzoate transport; Region: 2A0115; TIGR00895 1155777000889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777000890 putative substrate translocation pore; other site 1155777000891 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1155777000892 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1155777000893 Walker A/P-loop; other site 1155777000894 ATP binding site [chemical binding]; other site 1155777000895 Q-loop/lid; other site 1155777000896 ABC transporter signature motif; other site 1155777000897 Walker B; other site 1155777000898 D-loop; other site 1155777000899 H-loop/switch region; other site 1155777000900 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1155777000901 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1155777000902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777000903 dimer interface [polypeptide binding]; other site 1155777000904 conserved gate region; other site 1155777000905 putative PBP binding loops; other site 1155777000906 ABC-ATPase subunit interface; other site 1155777000907 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1155777000908 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1155777000909 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1155777000910 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1155777000911 amidohydrolase; Region: amidohydrolases; TIGR01891 1155777000912 metal binding site [ion binding]; metal-binding site 1155777000913 putative dimer interface [polypeptide binding]; other site 1155777000914 Predicted membrane protein [Function unknown]; Region: COG1288 1155777000915 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1155777000916 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1155777000917 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1155777000918 active site 1155777000919 Ca binding site [ion binding]; other site 1155777000920 catalytic site [active] 1155777000921 Aamy_C domain; Region: Aamy_C; smart00632 1155777000922 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1155777000923 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1155777000924 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155777000925 NAD binding site [chemical binding]; other site 1155777000926 dimer interface [polypeptide binding]; other site 1155777000927 substrate binding site [chemical binding]; other site 1155777000928 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1155777000929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777000930 putative substrate translocation pore; other site 1155777000931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777000932 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777000933 MarR family; Region: MarR; pfam01047 1155777000934 LysE type translocator; Region: LysE; pfam01810 1155777000935 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1155777000936 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155777000937 Spore germination protein; Region: Spore_permease; cl17796 1155777000938 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1155777000939 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1155777000940 NAD+ synthetase; Region: nadE; TIGR00552 1155777000941 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1155777000942 homodimer interface [polypeptide binding]; other site 1155777000943 NAD binding pocket [chemical binding]; other site 1155777000944 ATP binding pocket [chemical binding]; other site 1155777000945 Mg binding site [ion binding]; other site 1155777000946 active-site loop [active] 1155777000947 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1155777000948 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1155777000949 AAA domain; Region: AAA_18; pfam13238 1155777000950 active site 1155777000951 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1155777000952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777000953 D-galactonate transporter; Region: 2A0114; TIGR00893 1155777000954 putative substrate translocation pore; other site 1155777000955 shikimate kinase; Reviewed; Region: aroK; PRK00131 1155777000956 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1155777000957 ADP binding site [chemical binding]; other site 1155777000958 magnesium binding site [ion binding]; other site 1155777000959 putative shikimate binding site; other site 1155777000960 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1155777000961 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1155777000962 Proline dehydrogenase; Region: Pro_dh; pfam01619 1155777000963 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1155777000964 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1155777000965 Glutamate binding site [chemical binding]; other site 1155777000966 homodimer interface [polypeptide binding]; other site 1155777000967 NAD binding site [chemical binding]; other site 1155777000968 catalytic residues [active] 1155777000969 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1155777000970 Na binding site [ion binding]; other site 1155777000971 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1155777000972 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1155777000973 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1155777000974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155777000975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777000976 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1155777000977 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1155777000978 active site 1155777000979 SAM binding site [chemical binding]; other site 1155777000980 homodimer interface [polypeptide binding]; other site 1155777000981 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1155777000982 [2Fe-2S] cluster binding site [ion binding]; other site 1155777000983 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1155777000984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777000985 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1155777000986 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1155777000987 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1155777000988 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1155777000989 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1155777000990 [4Fe-4S] binding site [ion binding]; other site 1155777000991 molybdopterin cofactor binding site; other site 1155777000992 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1155777000993 molybdopterin cofactor binding site; other site 1155777000994 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1155777000995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777000996 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1155777000997 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1155777000998 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1155777000999 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1155777001000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001001 putative substrate translocation pore; other site 1155777001002 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1155777001003 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1155777001004 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1155777001005 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1155777001006 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155777001007 NAD binding site [chemical binding]; other site 1155777001008 catalytic Zn binding site [ion binding]; other site 1155777001009 structural Zn binding site [ion binding]; other site 1155777001010 RDD family; Region: RDD; pfam06271 1155777001011 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1155777001012 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155777001013 beta-galactosidase; Region: BGL; TIGR03356 1155777001014 Competence protein J (ComJ); Region: ComJ; pfam11033 1155777001015 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1155777001016 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155777001017 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1155777001018 tetramer interface [polypeptide binding]; other site 1155777001019 active site 1155777001020 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1155777001021 active site 1155777001022 dimer interface [polypeptide binding]; other site 1155777001023 magnesium binding site [ion binding]; other site 1155777001024 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155777001025 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155777001026 Condensation domain; Region: Condensation; pfam00668 1155777001027 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777001028 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777001029 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777001030 acyl-activating enzyme (AAE) consensus motif; other site 1155777001031 AMP binding site [chemical binding]; other site 1155777001032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777001033 Condensation domain; Region: Condensation; pfam00668 1155777001034 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777001035 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777001036 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1155777001037 acyl-activating enzyme (AAE) consensus motif; other site 1155777001038 AMP binding site [chemical binding]; other site 1155777001039 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777001040 Condensation domain; Region: Condensation; pfam00668 1155777001041 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777001042 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777001043 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777001044 acyl-activating enzyme (AAE) consensus motif; other site 1155777001045 AMP binding site [chemical binding]; other site 1155777001046 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777001047 Condensation domain; Region: Condensation; pfam00668 1155777001048 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777001049 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777001050 Condensation domain; Region: Condensation; pfam00668 1155777001051 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777001052 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1155777001053 acyl-activating enzyme (AAE) consensus motif; other site 1155777001054 AMP binding site [chemical binding]; other site 1155777001055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777001056 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1155777001057 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1155777001058 PGAP1-like protein; Region: PGAP1; pfam07819 1155777001059 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1155777001060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777001061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777001062 homodimer interface [polypeptide binding]; other site 1155777001063 catalytic residue [active] 1155777001064 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1155777001065 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1155777001066 Predicted membrane protein [Function unknown]; Region: COG2364 1155777001067 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777001068 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155777001069 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155777001070 Walker A/P-loop; other site 1155777001071 ATP binding site [chemical binding]; other site 1155777001072 Q-loop/lid; other site 1155777001073 ABC transporter signature motif; other site 1155777001074 Walker B; other site 1155777001075 D-loop; other site 1155777001076 H-loop/switch region; other site 1155777001077 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155777001078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777001079 dimer interface [polypeptide binding]; other site 1155777001080 conserved gate region; other site 1155777001081 putative PBP binding loops; other site 1155777001082 ABC-ATPase subunit interface; other site 1155777001083 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1155777001084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155777001085 substrate binding pocket [chemical binding]; other site 1155777001086 membrane-bound complex binding site; other site 1155777001087 hinge residues; other site 1155777001088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777001089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777001090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777001091 dimerization interface [polypeptide binding]; other site 1155777001092 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1155777001093 Flavoprotein; Region: Flavoprotein; pfam02441 1155777001094 UbiD family decarboxylase; Region: TIGR00148 1155777001095 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1155777001096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001097 putative substrate translocation pore; other site 1155777001098 POT family; Region: PTR2; pfam00854 1155777001099 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1155777001100 Right handed beta helix region; Region: Beta_helix; pfam13229 1155777001101 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1155777001102 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1155777001103 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1155777001104 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1155777001105 Spore germination protein; Region: Spore_permease; pfam03845 1155777001106 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1155777001107 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1155777001108 active site 1155777001109 non-prolyl cis peptide bond; other site 1155777001110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777001111 Coenzyme A binding pocket [chemical binding]; other site 1155777001112 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155777001113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155777001114 substrate binding pocket [chemical binding]; other site 1155777001115 membrane-bound complex binding site; other site 1155777001116 hinge residues; other site 1155777001117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777001118 dimer interface [polypeptide binding]; other site 1155777001119 conserved gate region; other site 1155777001120 putative PBP binding loops; other site 1155777001121 ABC-ATPase subunit interface; other site 1155777001122 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155777001123 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155777001124 Walker A/P-loop; other site 1155777001125 ATP binding site [chemical binding]; other site 1155777001126 Q-loop/lid; other site 1155777001127 ABC transporter signature motif; other site 1155777001128 Walker B; other site 1155777001129 D-loop; other site 1155777001130 H-loop/switch region; other site 1155777001131 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155777001132 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1155777001133 metal binding site [ion binding]; metal-binding site 1155777001134 dimer interface [polypeptide binding]; other site 1155777001135 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1155777001136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155777001137 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155777001138 Walker A/P-loop; other site 1155777001139 ATP binding site [chemical binding]; other site 1155777001140 Q-loop/lid; other site 1155777001141 ABC transporter signature motif; other site 1155777001142 Walker B; other site 1155777001143 D-loop; other site 1155777001144 H-loop/switch region; other site 1155777001145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155777001146 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155777001147 FtsX-like permease family; Region: FtsX; pfam02687 1155777001148 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777001149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777001150 active site 1155777001151 phosphorylation site [posttranslational modification] 1155777001152 intermolecular recognition site; other site 1155777001153 dimerization interface [polypeptide binding]; other site 1155777001154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777001155 DNA binding site [nucleotide binding] 1155777001156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777001157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777001158 dimerization interface [polypeptide binding]; other site 1155777001159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777001160 dimer interface [polypeptide binding]; other site 1155777001161 phosphorylation site [posttranslational modification] 1155777001162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777001163 ATP binding site [chemical binding]; other site 1155777001164 Mg2+ binding site [ion binding]; other site 1155777001165 G-X-G motif; other site 1155777001166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1155777001167 binding surface 1155777001168 TPR motif; other site 1155777001169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777001170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777001171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777001172 TPR motif; other site 1155777001173 binding surface 1155777001174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777001175 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1155777001176 aspartate kinase; Reviewed; Region: PRK09034 1155777001177 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1155777001178 putative catalytic residues [active] 1155777001179 putative nucleotide binding site [chemical binding]; other site 1155777001180 putative aspartate binding site [chemical binding]; other site 1155777001181 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1155777001182 allosteric regulatory residue; other site 1155777001183 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1155777001184 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155777001185 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777001186 ABC-ATPase subunit interface; other site 1155777001187 dimer interface [polypeptide binding]; other site 1155777001188 putative PBP binding regions; other site 1155777001189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777001190 ABC-ATPase subunit interface; other site 1155777001191 dimer interface [polypeptide binding]; other site 1155777001192 putative PBP binding regions; other site 1155777001193 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1155777001194 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155777001195 Walker A/P-loop; other site 1155777001196 ATP binding site [chemical binding]; other site 1155777001197 Q-loop/lid; other site 1155777001198 ABC transporter signature motif; other site 1155777001199 Walker B; other site 1155777001200 D-loop; other site 1155777001201 H-loop/switch region; other site 1155777001202 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1155777001203 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1155777001204 putative ligand binding residues [chemical binding]; other site 1155777001205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777001207 putative substrate translocation pore; other site 1155777001208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777001210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777001211 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1155777001212 dimer interface [polypeptide binding]; other site 1155777001213 FMN binding site [chemical binding]; other site 1155777001214 NADPH bind site [chemical binding]; other site 1155777001215 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1155777001216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777001217 dimerization interface [polypeptide binding]; other site 1155777001218 putative DNA binding site [nucleotide binding]; other site 1155777001219 putative Zn2+ binding site [ion binding]; other site 1155777001220 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155777001221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777001222 DNA-binding site [nucleotide binding]; DNA binding site 1155777001223 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777001224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777001225 homodimer interface [polypeptide binding]; other site 1155777001226 catalytic residue [active] 1155777001227 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1155777001228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777001229 inhibitor-cofactor binding pocket; inhibition site 1155777001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777001231 catalytic residue [active] 1155777001232 succinic semialdehyde dehydrogenase; Region: PLN02278 1155777001233 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1155777001234 tetramerization interface [polypeptide binding]; other site 1155777001235 NAD(P) binding site [chemical binding]; other site 1155777001236 catalytic residues [active] 1155777001237 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1155777001238 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1155777001239 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1155777001240 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1155777001241 NAD binding site [chemical binding]; other site 1155777001242 homodimer interface [polypeptide binding]; other site 1155777001243 active site 1155777001244 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1155777001245 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1155777001246 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1155777001247 YtkA-like; Region: YtkA; pfam13115 1155777001248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155777001249 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1155777001250 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1155777001251 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1155777001252 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1155777001253 active site 1155777001254 P-loop; other site 1155777001255 phosphorylation site [posttranslational modification] 1155777001256 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155777001257 active site 1155777001258 phosphorylation site [posttranslational modification] 1155777001259 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1155777001260 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1155777001261 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1155777001262 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1155777001263 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1155777001264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777001265 active site 1155777001266 motif I; other site 1155777001267 motif II; other site 1155777001268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777001269 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1155777001270 putative active site [active] 1155777001271 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1155777001272 hypothetical protein; Provisional; Region: PRK05463 1155777001273 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1155777001274 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1155777001275 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1155777001276 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1155777001277 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1155777001278 Bacterial transcriptional regulator; Region: IclR; pfam01614 1155777001279 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1155777001280 active site 1155777001281 catalytic triad [active] 1155777001282 oxyanion hole [active] 1155777001283 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1155777001284 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1155777001285 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1155777001286 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155777001287 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155777001288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155777001289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155777001290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155777001291 active site 1155777001292 catalytic tetrad [active] 1155777001293 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155777001294 HTH domain; Region: HTH_11; pfam08279 1155777001295 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155777001296 PRD domain; Region: PRD; pfam00874 1155777001297 PRD domain; Region: PRD; pfam00874 1155777001298 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155777001299 active site 1155777001300 P-loop; other site 1155777001301 phosphorylation site [posttranslational modification] 1155777001302 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1155777001303 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1155777001304 acyl-activating enzyme (AAE) consensus motif; other site 1155777001305 putative AMP binding site [chemical binding]; other site 1155777001306 putative active site [active] 1155777001307 putative CoA binding site [chemical binding]; other site 1155777001308 short chain dehydrogenase; Provisional; Region: PRK06701 1155777001309 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1155777001310 NAD binding site [chemical binding]; other site 1155777001311 metal binding site [ion binding]; metal-binding site 1155777001312 active site 1155777001313 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1155777001314 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155777001315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155777001316 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1155777001317 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1155777001318 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1155777001319 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1155777001320 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1155777001321 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1155777001322 putative DNA binding site [nucleotide binding]; other site 1155777001323 putative Zn2+ binding site [ion binding]; other site 1155777001324 AsnC family; Region: AsnC_trans_reg; pfam01037 1155777001325 DNA topoisomerase III; Provisional; Region: PRK07726 1155777001326 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1155777001327 active site 1155777001328 putative interdomain interaction site [polypeptide binding]; other site 1155777001329 putative metal-binding site [ion binding]; other site 1155777001330 putative nucleotide binding site [chemical binding]; other site 1155777001331 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155777001332 domain I; other site 1155777001333 DNA binding groove [nucleotide binding] 1155777001334 phosphate binding site [ion binding]; other site 1155777001335 domain II; other site 1155777001336 domain III; other site 1155777001337 nucleotide binding site [chemical binding]; other site 1155777001338 catalytic site [active] 1155777001339 domain IV; other site 1155777001340 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1155777001341 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1155777001342 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1155777001343 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1155777001344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1155777001345 metal binding site [ion binding]; metal-binding site 1155777001346 active site 1155777001347 I-site; other site 1155777001348 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1155777001349 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1155777001350 NodB motif; other site 1155777001351 putative active site [active] 1155777001352 putative catalytic site [active] 1155777001353 putative Zn binding site [ion binding]; other site 1155777001354 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1155777001355 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1155777001356 DXD motif; other site 1155777001357 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1155777001358 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1155777001359 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1155777001360 nudix motif; other site 1155777001361 pyruvate oxidase; Provisional; Region: PRK08611 1155777001362 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1155777001363 PYR/PP interface [polypeptide binding]; other site 1155777001364 dimer interface [polypeptide binding]; other site 1155777001365 tetramer interface [polypeptide binding]; other site 1155777001366 TPP binding site [chemical binding]; other site 1155777001367 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155777001368 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1155777001369 TPP-binding site [chemical binding]; other site 1155777001370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155777001371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777001372 Coenzyme A binding pocket [chemical binding]; other site 1155777001373 manganese transport protein MntH; Reviewed; Region: PRK00701 1155777001374 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1155777001375 Bacterial SH3 domain; Region: SH3_3; cl17532 1155777001376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1155777001377 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1155777001378 EcsC protein family; Region: EcsC; pfam12787 1155777001379 General stress protein [General function prediction only]; Region: GsiB; COG3729 1155777001380 General stress protein [General function prediction only]; Region: GsiB; COG3729 1155777001381 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1155777001382 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1155777001383 dimanganese center [ion binding]; other site 1155777001384 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1155777001385 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1155777001386 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1155777001387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777001388 putative active site [active] 1155777001389 heme pocket [chemical binding]; other site 1155777001390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777001391 ATP binding site [chemical binding]; other site 1155777001392 Mg2+ binding site [ion binding]; other site 1155777001393 G-X-G motif; other site 1155777001394 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1155777001395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777001396 active site 1155777001397 phosphorylation site [posttranslational modification] 1155777001398 intermolecular recognition site; other site 1155777001399 dimerization interface [polypeptide binding]; other site 1155777001400 HTH domain; Region: HTH_11; pfam08279 1155777001401 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1155777001402 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1155777001403 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155777001404 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155777001405 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777001406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777001407 Walker A/P-loop; other site 1155777001408 ATP binding site [chemical binding]; other site 1155777001409 Q-loop/lid; other site 1155777001410 ABC transporter signature motif; other site 1155777001411 Walker B; other site 1155777001412 D-loop; other site 1155777001413 H-loop/switch region; other site 1155777001414 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1155777001415 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155777001416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1155777001417 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1155777001418 active site 1155777001419 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1155777001420 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155777001421 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1155777001422 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155777001423 catalytic residues [active] 1155777001424 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1155777001425 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1155777001426 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1155777001427 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1155777001428 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155777001429 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155777001430 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155777001431 helicase 45; Provisional; Region: PTZ00424 1155777001432 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155777001433 ATP binding site [chemical binding]; other site 1155777001434 Mg++ binding site [ion binding]; other site 1155777001435 motif III; other site 1155777001436 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777001437 nucleotide binding region [chemical binding]; other site 1155777001438 ATP-binding site [chemical binding]; other site 1155777001439 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1155777001440 Predicted membrane protein [Function unknown]; Region: COG3428 1155777001441 Bacterial PH domain; Region: DUF304; pfam03703 1155777001442 Bacterial PH domain; Region: DUF304; pfam03703 1155777001443 Bacterial PH domain; Region: DUF304; pfam03703 1155777001444 Rhomboid family; Region: Rhomboid; pfam01694 1155777001445 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1155777001446 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1155777001447 alanine racemase; Region: alr; TIGR00492 1155777001448 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1155777001449 active site 1155777001450 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155777001451 dimer interface [polypeptide binding]; other site 1155777001452 substrate binding site [chemical binding]; other site 1155777001453 catalytic residues [active] 1155777001454 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1155777001455 ribbon-helix-helix domain containing protein; Region: PHA00617 1155777001456 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1155777001457 Rsbr N terminal; Region: Rsbr_N; pfam08678 1155777001458 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1155777001459 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1155777001460 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1155777001461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777001462 ATP binding site [chemical binding]; other site 1155777001463 Mg2+ binding site [ion binding]; other site 1155777001464 G-X-G motif; other site 1155777001465 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1155777001466 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1155777001467 CoA binding domain; Region: CoA_binding; cl17356 1155777001468 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1155777001469 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1155777001470 anti sigma factor interaction site; other site 1155777001471 regulatory phosphorylation site [posttranslational modification]; other site 1155777001472 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1155777001473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777001474 ATP binding site [chemical binding]; other site 1155777001475 Mg2+ binding site [ion binding]; other site 1155777001476 G-X-G motif; other site 1155777001477 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1155777001478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777001479 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155777001480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777001481 DNA binding residues [nucleotide binding] 1155777001482 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1155777001483 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1155777001484 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1155777001485 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1155777001486 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1155777001487 RNA binding site [nucleotide binding]; other site 1155777001488 SprT homologues; Region: SprT; cl01182 1155777001489 hypothetical protein; Provisional; Region: PRK04351 1155777001490 BCCT family transporter; Region: BCCT; cl00569 1155777001491 proline/glycine betaine transporter; Provisional; Region: PRK10642 1155777001492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001493 putative substrate translocation pore; other site 1155777001494 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1155777001495 putative active site [active] 1155777001496 putative catalytic site [active] 1155777001497 Predicted transcriptional regulator [Transcription]; Region: COG1959 1155777001498 Transcriptional regulator; Region: Rrf2; pfam02082 1155777001499 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1155777001500 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1155777001501 NAD binding site [chemical binding]; other site 1155777001502 substrate binding site [chemical binding]; other site 1155777001503 putative active site [active] 1155777001504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777001506 putative substrate translocation pore; other site 1155777001507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777001508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777001509 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1155777001510 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1155777001511 putative di-iron ligands [ion binding]; other site 1155777001512 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155777001513 DNA-binding site [nucleotide binding]; DNA binding site 1155777001514 RNA-binding motif; other site 1155777001515 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1155777001516 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1155777001517 putative homodimer interface [polypeptide binding]; other site 1155777001518 putative homotetramer interface [polypeptide binding]; other site 1155777001519 putative metal binding site [ion binding]; other site 1155777001520 putative homodimer-homodimer interface [polypeptide binding]; other site 1155777001521 putative allosteric switch controlling residues; other site 1155777001522 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1155777001523 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155777001524 active site residue [active] 1155777001525 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1155777001526 CPxP motif; other site 1155777001527 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155777001528 active site residue [active] 1155777001529 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1155777001530 active site residue [active] 1155777001531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155777001532 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1155777001533 CPxP motif; other site 1155777001534 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1155777001535 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1155777001536 aspartate racemase; Region: asp_race; TIGR00035 1155777001537 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1155777001538 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155777001539 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1155777001540 Patatin [General function prediction only]; Region: COG3621 1155777001541 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1155777001542 active site 1155777001543 nucleophile elbow; other site 1155777001544 DinB family; Region: DinB; cl17821 1155777001545 DinB superfamily; Region: DinB_2; pfam12867 1155777001546 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1155777001547 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1155777001548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155777001549 catalytic residue [active] 1155777001550 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1155777001551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777001552 DNA-binding site [nucleotide binding]; DNA binding site 1155777001553 FCD domain; Region: FCD; pfam07729 1155777001554 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1155777001555 homotrimer interaction site [polypeptide binding]; other site 1155777001556 putative active site [active] 1155777001557 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1155777001558 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1155777001559 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155777001560 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1155777001561 metal binding site [ion binding]; metal-binding site 1155777001562 putative dimer interface [polypeptide binding]; other site 1155777001563 Cupin domain; Region: Cupin_2; pfam07883 1155777001564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155777001565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777001566 allantoate amidohydrolase; Reviewed; Region: PRK12890 1155777001567 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1155777001568 active site 1155777001569 metal binding site [ion binding]; metal-binding site 1155777001570 dimer interface [polypeptide binding]; other site 1155777001571 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155777001572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777001573 DNA-binding site [nucleotide binding]; DNA binding site 1155777001574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777001575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777001576 homodimer interface [polypeptide binding]; other site 1155777001577 catalytic residue [active] 1155777001578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001579 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777001580 putative substrate translocation pore; other site 1155777001581 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1155777001582 nudix motif; other site 1155777001583 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1155777001584 FAD binding domain; Region: FAD_binding_4; pfam01565 1155777001585 Berberine and berberine like; Region: BBE; pfam08031 1155777001586 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155777001587 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1155777001588 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155777001589 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1155777001590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1155777001591 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1155777001592 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1155777001593 DinB superfamily; Region: DinB_2; pfam12867 1155777001594 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1155777001595 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1155777001596 inhibitor site; inhibition site 1155777001597 active site 1155777001598 dimer interface [polypeptide binding]; other site 1155777001599 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1155777001600 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1155777001601 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1155777001602 dimerization interface [polypeptide binding]; other site 1155777001603 active site 1155777001604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777001605 S-adenosylmethionine binding site [chemical binding]; other site 1155777001606 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1155777001607 dimer interface [polypeptide binding]; other site 1155777001608 substrate binding site [chemical binding]; other site 1155777001609 ATP binding site [chemical binding]; other site 1155777001610 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1155777001611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777001612 active site 1155777001613 motif I; other site 1155777001614 motif II; other site 1155777001615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777001616 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1155777001617 nudix motif; other site 1155777001618 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1155777001619 Sodium Bile acid symporter family; Region: SBF; cl17470 1155777001620 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1155777001621 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1155777001622 putative NAD(P) binding site [chemical binding]; other site 1155777001623 putative substrate binding site [chemical binding]; other site 1155777001624 catalytic Zn binding site [ion binding]; other site 1155777001625 structural Zn binding site [ion binding]; other site 1155777001626 dimer interface [polypeptide binding]; other site 1155777001627 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155777001628 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1155777001629 DNA binding residues [nucleotide binding] 1155777001630 putative dimer interface [polypeptide binding]; other site 1155777001631 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1155777001632 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155777001633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777001634 DNA-binding site [nucleotide binding]; DNA binding site 1155777001635 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777001636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777001637 homodimer interface [polypeptide binding]; other site 1155777001638 catalytic residue [active] 1155777001639 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1155777001640 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777001643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777001644 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1155777001645 EamA-like transporter family; Region: EamA; cl17759 1155777001646 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155777001647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777001648 DNA-binding site [nucleotide binding]; DNA binding site 1155777001649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777001650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777001651 homodimer interface [polypeptide binding]; other site 1155777001652 catalytic residue [active] 1155777001653 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1155777001654 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1155777001655 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155777001656 NAD binding site [chemical binding]; other site 1155777001657 catalytic Zn binding site [ion binding]; other site 1155777001658 structural Zn binding site [ion binding]; other site 1155777001659 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1155777001660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777001662 putative substrate translocation pore; other site 1155777001663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1155777001664 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1155777001665 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1155777001666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155777001667 K+ potassium transporter; Region: K_trans; cl15781 1155777001668 Histidine kinase; Region: HisKA_3; pfam07730 1155777001669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777001670 ATP binding site [chemical binding]; other site 1155777001671 Mg2+ binding site [ion binding]; other site 1155777001672 G-X-G motif; other site 1155777001673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777001674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777001675 active site 1155777001676 phosphorylation site [posttranslational modification] 1155777001677 intermolecular recognition site; other site 1155777001678 dimerization interface [polypeptide binding]; other site 1155777001679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777001680 DNA binding residues [nucleotide binding] 1155777001681 dimerization interface [polypeptide binding]; other site 1155777001682 MMPL family; Region: MMPL; pfam03176 1155777001683 MMPL family; Region: MMPL; pfam03176 1155777001684 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1155777001685 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1155777001686 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1155777001687 catalytic triad [active] 1155777001688 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155777001689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777001690 ABC transporter; Region: ABC_tran_2; pfam12848 1155777001691 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777001692 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155777001693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777001694 Coenzyme A binding pocket [chemical binding]; other site 1155777001695 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155777001696 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777001697 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777001698 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155777001699 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1155777001700 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1155777001701 dimer interface [polypeptide binding]; other site 1155777001702 active site 1155777001703 metal binding site [ion binding]; metal-binding site 1155777001704 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1155777001705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001706 putative substrate translocation pore; other site 1155777001707 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1155777001708 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1155777001709 dimer interface [polypeptide binding]; other site 1155777001710 active site 1155777001711 Helix-turn-helix domain; Region: HTH_31; pfam13560 1155777001712 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1155777001713 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1155777001714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777001715 Coenzyme A binding pocket [chemical binding]; other site 1155777001716 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1155777001717 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155777001718 DNA binding residues [nucleotide binding] 1155777001719 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1155777001720 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1155777001721 EamA-like transporter family; Region: EamA; pfam00892 1155777001722 EamA-like transporter family; Region: EamA; pfam00892 1155777001723 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1155777001724 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1155777001725 nudix motif; other site 1155777001726 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155777001727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777001728 S-adenosylmethionine binding site [chemical binding]; other site 1155777001729 tartrate dehydrogenase; Provisional; Region: PRK08194 1155777001730 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1155777001731 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1155777001732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777001733 DNA-binding site [nucleotide binding]; DNA binding site 1155777001734 FCD domain; Region: FCD; pfam07729 1155777001735 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1155777001736 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1155777001737 active site 1155777001738 TDP-binding site; other site 1155777001739 acceptor substrate-binding pocket; other site 1155777001740 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155777001741 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155777001742 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1155777001743 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1155777001744 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1155777001745 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777001746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001747 putative substrate translocation pore; other site 1155777001748 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155777001749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777001750 DNA-binding site [nucleotide binding]; DNA binding site 1155777001751 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1155777001752 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1155777001753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777001754 DNA-binding site [nucleotide binding]; DNA binding site 1155777001755 FCD domain; Region: FCD; pfam07729 1155777001756 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1155777001757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001758 putative substrate translocation pore; other site 1155777001759 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1155777001760 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1155777001761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777001762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777001763 amino acid transporter; Region: 2A0306; TIGR00909 1155777001764 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1155777001765 dimanganese center [ion binding]; other site 1155777001766 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1155777001767 putative hydrophobic ligand binding site [chemical binding]; other site 1155777001768 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1155777001769 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1155777001770 putative NADP binding site [chemical binding]; other site 1155777001771 putative dimer interface [polypeptide binding]; other site 1155777001772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001773 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1155777001774 putative substrate translocation pore; other site 1155777001775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001776 thiamine monophosphate kinase; Provisional; Region: PRK05731 1155777001777 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1155777001778 ATP binding site [chemical binding]; other site 1155777001779 dimerization interface [polypeptide binding]; other site 1155777001780 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1155777001781 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1155777001782 Glycoprotease family; Region: Peptidase_M22; pfam00814 1155777001783 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1155777001784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777001785 Coenzyme A binding pocket [chemical binding]; other site 1155777001786 UGMP family protein; Validated; Region: PRK09604 1155777001787 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1155777001788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1155777001789 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155777001790 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777001791 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777001792 ABC transporter; Region: ABC_tran_2; pfam12848 1155777001793 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777001794 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1155777001795 trimer interface [polypeptide binding]; other site 1155777001796 dimer interface [polypeptide binding]; other site 1155777001797 putative active site [active] 1155777001798 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1155777001799 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1155777001800 CoA binding domain; Region: CoA_binding; pfam02629 1155777001801 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1155777001802 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1155777001803 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1155777001804 CAAX protease self-immunity; Region: Abi; pfam02517 1155777001805 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1155777001806 oligomerisation interface [polypeptide binding]; other site 1155777001807 mobile loop; other site 1155777001808 roof hairpin; other site 1155777001809 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1155777001810 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1155777001811 ring oligomerisation interface [polypeptide binding]; other site 1155777001812 ATP/Mg binding site [chemical binding]; other site 1155777001813 stacking interactions; other site 1155777001814 hinge regions; other site 1155777001815 AAA ATPase domain; Region: AAA_16; pfam13191 1155777001816 Walker A motif; other site 1155777001817 ATP binding site [chemical binding]; other site 1155777001818 Walker B motif; other site 1155777001819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777001820 binding surface 1155777001821 TPR motif; other site 1155777001822 TPR repeat; Region: TPR_11; pfam13414 1155777001823 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155777001824 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1155777001825 inhibitor binding site; inhibition site 1155777001826 catalytic Zn binding site [ion binding]; other site 1155777001827 structural Zn binding site [ion binding]; other site 1155777001828 NADP binding site [chemical binding]; other site 1155777001829 tetramer interface [polypeptide binding]; other site 1155777001830 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1155777001831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001832 putative substrate translocation pore; other site 1155777001833 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155777001834 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1155777001835 putative substrate binding site [chemical binding]; other site 1155777001836 putative ATP binding site [chemical binding]; other site 1155777001837 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1155777001838 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1155777001839 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1155777001840 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1155777001841 Repair protein; Region: Repair_PSII; pfam04536 1155777001842 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1155777001843 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1155777001844 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1155777001845 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1155777001846 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1155777001847 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1155777001848 catalytic triad [active] 1155777001849 catalytic triad [active] 1155777001850 oxyanion hole [active] 1155777001851 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1155777001852 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1155777001853 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1155777001854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777001855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777001856 DNA binding residues [nucleotide binding] 1155777001857 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155777001858 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1155777001859 putative NAD(P) binding site [chemical binding]; other site 1155777001860 catalytic Zn binding site [ion binding]; other site 1155777001861 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1155777001862 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1155777001863 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1155777001864 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1155777001865 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1155777001866 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1155777001867 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1155777001868 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1155777001869 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155777001870 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1155777001871 MoxR-like ATPases [General function prediction only]; Region: COG0714 1155777001872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777001873 Walker A motif; other site 1155777001874 ATP binding site [chemical binding]; other site 1155777001875 Walker B motif; other site 1155777001876 arginine finger; other site 1155777001877 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1155777001878 Protein of unknown function DUF58; Region: DUF58; pfam01882 1155777001879 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1155777001880 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1155777001881 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1155777001882 GMP synthase; Reviewed; Region: guaA; PRK00074 1155777001883 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1155777001884 AMP/PPi binding site [chemical binding]; other site 1155777001885 candidate oxyanion hole; other site 1155777001886 catalytic triad [active] 1155777001887 potential glutamine specificity residues [chemical binding]; other site 1155777001888 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1155777001889 ATP Binding subdomain [chemical binding]; other site 1155777001890 Ligand Binding sites [chemical binding]; other site 1155777001891 Dimerization subdomain; other site 1155777001892 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1155777001893 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1155777001894 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1155777001895 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1155777001896 tetramer interface [polypeptide binding]; other site 1155777001897 active site 1155777001898 Mg2+/Mn2+ binding site [ion binding]; other site 1155777001899 aspartate aminotransferase; Provisional; Region: PRK05764 1155777001900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777001901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777001902 homodimer interface [polypeptide binding]; other site 1155777001903 catalytic residue [active] 1155777001904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777001905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777001906 putative substrate translocation pore; other site 1155777001907 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1155777001908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777001909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777001910 DNA binding residues [nucleotide binding] 1155777001911 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1155777001912 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1155777001913 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1155777001914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1155777001915 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155777001916 NETI protein; Region: NETI; pfam14044 1155777001917 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1155777001918 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1155777001919 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1155777001920 NAD binding site [chemical binding]; other site 1155777001921 ATP-grasp domain; Region: ATP-grasp; pfam02222 1155777001922 adenylosuccinate lyase; Provisional; Region: PRK07492 1155777001923 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1155777001924 tetramer interface [polypeptide binding]; other site 1155777001925 active site 1155777001926 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1155777001927 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1155777001928 ATP binding site [chemical binding]; other site 1155777001929 active site 1155777001930 substrate binding site [chemical binding]; other site 1155777001931 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1155777001932 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1155777001933 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1155777001934 putative active site [active] 1155777001935 catalytic triad [active] 1155777001936 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1155777001937 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1155777001938 dimerization interface [polypeptide binding]; other site 1155777001939 ATP binding site [chemical binding]; other site 1155777001940 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1155777001941 dimerization interface [polypeptide binding]; other site 1155777001942 ATP binding site [chemical binding]; other site 1155777001943 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1155777001944 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1155777001945 active site 1155777001946 tetramer interface [polypeptide binding]; other site 1155777001947 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777001948 active site 1155777001949 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1155777001950 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1155777001951 dimerization interface [polypeptide binding]; other site 1155777001952 putative ATP binding site [chemical binding]; other site 1155777001953 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1155777001954 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1155777001955 active site 1155777001956 substrate binding site [chemical binding]; other site 1155777001957 cosubstrate binding site; other site 1155777001958 catalytic site [active] 1155777001959 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1155777001960 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1155777001961 purine monophosphate binding site [chemical binding]; other site 1155777001962 dimer interface [polypeptide binding]; other site 1155777001963 putative catalytic residues [active] 1155777001964 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1155777001965 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1155777001966 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1155777001967 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1155777001968 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1155777001969 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1155777001970 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1155777001971 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155777001972 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1155777001973 active site 1155777001974 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155777001975 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1155777001976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1155777001977 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1155777001978 active site 1155777001979 FMN binding site [chemical binding]; other site 1155777001980 substrate binding site [chemical binding]; other site 1155777001981 3Fe-4S cluster binding site [ion binding]; other site 1155777001982 PcrB family; Region: PcrB; pfam01884 1155777001983 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1155777001984 substrate binding site [chemical binding]; other site 1155777001985 putative active site [active] 1155777001986 dimer interface [polypeptide binding]; other site 1155777001987 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1155777001988 Part of AAA domain; Region: AAA_19; pfam13245 1155777001989 Family description; Region: UvrD_C_2; pfam13538 1155777001990 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1155777001991 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1155777001992 nucleotide binding pocket [chemical binding]; other site 1155777001993 K-X-D-G motif; other site 1155777001994 catalytic site [active] 1155777001995 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1155777001996 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1155777001997 Helix-hairpin-helix motif; Region: HHH; pfam00633 1155777001998 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1155777001999 Dimer interface [polypeptide binding]; other site 1155777002000 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1155777002001 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1155777002002 putative dimer interface [polypeptide binding]; other site 1155777002003 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1155777002004 putative dimer interface [polypeptide binding]; other site 1155777002005 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1155777002006 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1155777002007 active site 1155777002008 ATP binding site [chemical binding]; other site 1155777002009 substrate binding site [chemical binding]; other site 1155777002010 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1155777002011 MgtC family; Region: MgtC; pfam02308 1155777002012 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1155777002013 Na binding site [ion binding]; other site 1155777002014 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1155777002015 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1155777002016 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1155777002017 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1155777002018 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1155777002019 GatB domain; Region: GatB_Yqey; pfam02637 1155777002020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777002021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777002022 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1155777002023 Protein export membrane protein; Region: SecD_SecF; cl14618 1155777002024 putative lipid kinase; Reviewed; Region: PRK13337 1155777002025 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155777002026 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1155777002027 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1155777002028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777002029 S-adenosylmethionine binding site [chemical binding]; other site 1155777002030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155777002031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155777002032 Walker A/P-loop; other site 1155777002033 ATP binding site [chemical binding]; other site 1155777002034 Q-loop/lid; other site 1155777002035 ABC transporter signature motif; other site 1155777002036 Walker B; other site 1155777002037 D-loop; other site 1155777002038 H-loop/switch region; other site 1155777002039 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155777002040 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1155777002041 FtsX-like permease family; Region: FtsX; pfam02687 1155777002042 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1155777002043 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777002044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777002045 Walker A/P-loop; other site 1155777002046 ATP binding site [chemical binding]; other site 1155777002047 Q-loop/lid; other site 1155777002048 ABC transporter signature motif; other site 1155777002049 Walker B; other site 1155777002050 D-loop; other site 1155777002051 H-loop/switch region; other site 1155777002052 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1155777002053 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155777002054 Protein of unknown function, DUF600; Region: DUF600; pfam04634 1155777002055 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155777002056 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155777002057 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155777002058 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155777002059 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1155777002060 LXG domain of WXG superfamily; Region: LXG; pfam04740 1155777002061 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1155777002062 hypothetical protein; Provisional; Region: PRK12378 1155777002063 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1155777002064 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1155777002065 CotJB protein; Region: CotJB; pfam12652 1155777002066 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1155777002067 dimanganese center [ion binding]; other site 1155777002068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777002069 Coenzyme A binding pocket [chemical binding]; other site 1155777002070 YesK-like protein; Region: YesK; pfam14150 1155777002071 Predicted membrane protein [Function unknown]; Region: COG2323 1155777002072 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1155777002073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777002074 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155777002075 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155777002076 active site 1155777002077 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1155777002078 Uncharacterized small protein [Function unknown]; Region: COG5583 1155777002079 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1155777002080 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1155777002081 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777002082 MarR family; Region: MarR; pfam01047 1155777002083 hypothetical protein; Provisional; Region: PRK06847 1155777002084 hypothetical protein; Provisional; Region: PRK07236 1155777002085 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1155777002086 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1155777002087 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1155777002088 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1155777002089 Cytochrome P450; Region: p450; pfam00067 1155777002090 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1155777002091 Flavodoxin; Region: Flavodoxin_1; pfam00258 1155777002092 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1155777002093 FAD binding pocket [chemical binding]; other site 1155777002094 FAD binding motif [chemical binding]; other site 1155777002095 catalytic residues [active] 1155777002096 NAD binding pocket [chemical binding]; other site 1155777002097 phosphate binding motif [ion binding]; other site 1155777002098 beta-alpha-beta structure motif; other site 1155777002099 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1155777002100 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777002101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155777002102 Walker A/P-loop; other site 1155777002103 ATP binding site [chemical binding]; other site 1155777002104 Q-loop/lid; other site 1155777002105 ABC transporter signature motif; other site 1155777002106 Walker B; other site 1155777002107 D-loop; other site 1155777002108 H-loop/switch region; other site 1155777002109 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1155777002110 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155777002111 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1155777002112 Sulfatase; Region: Sulfatase; pfam00884 1155777002113 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1155777002114 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1155777002115 substrate binding site; other site 1155777002116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155777002117 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1155777002118 NAD(P) binding site [chemical binding]; other site 1155777002119 active site 1155777002120 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1155777002121 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155777002122 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155777002123 active site 1155777002124 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1155777002125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002126 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777002127 putative substrate translocation pore; other site 1155777002128 amino acid transporter; Region: 2A0306; TIGR00909 1155777002129 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1155777002130 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1155777002131 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1155777002132 NAD(P) binding site [chemical binding]; other site 1155777002133 catalytic residues [active] 1155777002134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777002135 dimer interface [polypeptide binding]; other site 1155777002136 putative CheW interface [polypeptide binding]; other site 1155777002137 oxidoreductase; Provisional; Region: PRK07985 1155777002138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155777002139 NAD(P) binding site [chemical binding]; other site 1155777002140 active site 1155777002141 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1155777002142 putative metal binding site; other site 1155777002143 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155777002144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777002145 Walker A/P-loop; other site 1155777002146 ATP binding site [chemical binding]; other site 1155777002147 Q-loop/lid; other site 1155777002148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777002149 ABC transporter signature motif; other site 1155777002150 Walker B; other site 1155777002151 D-loop; other site 1155777002152 ABC transporter; Region: ABC_tran_2; pfam12848 1155777002153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777002154 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155777002155 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1155777002156 DNA binding residues [nucleotide binding] 1155777002157 putative dimer interface [polypeptide binding]; other site 1155777002158 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777002159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002160 putative substrate translocation pore; other site 1155777002161 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155777002162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777002163 Walker A/P-loop; other site 1155777002164 ATP binding site [chemical binding]; other site 1155777002165 Q-loop/lid; other site 1155777002166 ABC transporter signature motif; other site 1155777002167 Walker B; other site 1155777002168 D-loop; other site 1155777002169 H-loop/switch region; other site 1155777002170 ABC transporter; Region: ABC_tran_2; pfam12848 1155777002171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777002172 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155777002173 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155777002174 ATP binding site [chemical binding]; other site 1155777002175 Mg++ binding site [ion binding]; other site 1155777002176 motif III; other site 1155777002177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777002178 nucleotide binding region [chemical binding]; other site 1155777002179 ATP-binding site [chemical binding]; other site 1155777002180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777002181 Coenzyme A binding pocket [chemical binding]; other site 1155777002182 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1155777002183 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1155777002184 NAD(P) binding site [chemical binding]; other site 1155777002185 substrate binding site [chemical binding]; other site 1155777002186 dimer interface [polypeptide binding]; other site 1155777002187 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1155777002188 Heat induced stress protein YflT; Region: YflT; pfam11181 1155777002189 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1155777002190 Amb_all domain; Region: Amb_all; smart00656 1155777002191 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1155777002192 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1155777002193 transmembrane helices; other site 1155777002194 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1155777002195 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1155777002196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777002197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777002198 dimer interface [polypeptide binding]; other site 1155777002199 phosphorylation site [posttranslational modification] 1155777002200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777002201 ATP binding site [chemical binding]; other site 1155777002202 Mg2+ binding site [ion binding]; other site 1155777002203 G-X-G motif; other site 1155777002204 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1155777002205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777002206 active site 1155777002207 phosphorylation site [posttranslational modification] 1155777002208 intermolecular recognition site; other site 1155777002209 dimerization interface [polypeptide binding]; other site 1155777002210 Histidine kinase; Region: His_kinase; pfam06580 1155777002211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777002212 ATP binding site [chemical binding]; other site 1155777002213 Mg2+ binding site [ion binding]; other site 1155777002214 G-X-G motif; other site 1155777002215 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1155777002216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777002217 active site 1155777002218 phosphorylation site [posttranslational modification] 1155777002219 intermolecular recognition site; other site 1155777002220 dimerization interface [polypeptide binding]; other site 1155777002221 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1155777002222 DNA binding site [nucleotide binding] 1155777002223 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1155777002224 Collagen binding domain; Region: Collagen_bind; pfam05737 1155777002225 Collagen binding domain; Region: Collagen_bind; pfam05737 1155777002226 Collagen binding domain; Region: Collagen_bind; pfam05737 1155777002227 Cna protein B-type domain; Region: Cna_B; pfam05738 1155777002228 Cna protein B-type domain; Region: Cna_B; pfam05738 1155777002229 Cna protein B-type domain; Region: Cna_B; pfam05738 1155777002230 Cna protein B-type domain; Region: Cna_B; pfam05738 1155777002231 Cna protein B-type domain; Region: Cna_B; pfam05738 1155777002232 Cna protein B-type domain; Region: Cna_B; pfam05738 1155777002233 Cna protein B-type domain; Region: Cna_B; pfam05738 1155777002234 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1155777002235 active site 1155777002236 catalytic site [active] 1155777002237 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1155777002238 PAS domain; Region: PAS; smart00091 1155777002239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777002240 ATP binding site [chemical binding]; other site 1155777002241 Mg2+ binding site [ion binding]; other site 1155777002242 G-X-G motif; other site 1155777002243 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1155777002244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777002245 active site 1155777002246 phosphorylation site [posttranslational modification] 1155777002247 intermolecular recognition site; other site 1155777002248 dimerization interface [polypeptide binding]; other site 1155777002249 Transcriptional regulator; Region: CitT; pfam12431 1155777002250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1155777002251 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1155777002252 Citrate transporter; Region: CitMHS; pfam03600 1155777002253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155777002254 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1155777002255 active site 1155777002256 dimer interface [polypeptide binding]; other site 1155777002257 Acylphosphatase; Region: Acylphosphatase; cl00551 1155777002258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1155777002259 MOSC domain; Region: MOSC; pfam03473 1155777002260 3-alpha domain; Region: 3-alpha; pfam03475 1155777002261 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1155777002262 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1155777002263 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1155777002264 active site 1155777002265 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1155777002266 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155777002267 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155777002268 active site turn [active] 1155777002269 phosphorylation site [posttranslational modification] 1155777002270 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1155777002271 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1155777002272 Sulfatase; Region: Sulfatase; pfam00884 1155777002273 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1155777002274 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1155777002275 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1155777002276 putative dimer interface [polypeptide binding]; other site 1155777002277 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1155777002278 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1155777002279 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1155777002280 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155777002281 active site turn [active] 1155777002282 phosphorylation site [posttranslational modification] 1155777002283 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155777002284 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155777002285 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155777002286 Ca binding site [ion binding]; other site 1155777002287 active site 1155777002288 catalytic site [active] 1155777002289 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1155777002290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777002291 DNA-binding site [nucleotide binding]; DNA binding site 1155777002292 UTRA domain; Region: UTRA; pfam07702 1155777002293 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1155777002294 dimer interface [polypeptide binding]; other site 1155777002295 FMN binding site [chemical binding]; other site 1155777002296 YibE/F-like protein; Region: YibE_F; pfam07907 1155777002297 YibE/F-like protein; Region: YibE_F; pfam07907 1155777002298 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1155777002299 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1155777002300 active site 1155777002301 metal binding site [ion binding]; metal-binding site 1155777002302 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155777002303 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1155777002304 active site 1155777002305 metal binding site [ion binding]; metal-binding site 1155777002306 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155777002307 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1155777002308 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1155777002309 proposed catalytic triad [active] 1155777002310 conserved cys residue [active] 1155777002311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777002312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777002313 DNA binding site [nucleotide binding] 1155777002314 domain linker motif; other site 1155777002315 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1155777002316 putative dimerization interface [polypeptide binding]; other site 1155777002317 putative ligand binding site [chemical binding]; other site 1155777002318 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1155777002319 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1155777002320 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1155777002321 shikimate binding site; other site 1155777002322 NAD(P) binding site [chemical binding]; other site 1155777002323 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1155777002324 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1155777002325 active site 1155777002326 catalytic residue [active] 1155777002327 dimer interface [polypeptide binding]; other site 1155777002328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002329 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777002330 putative substrate translocation pore; other site 1155777002331 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1155777002332 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1155777002333 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1155777002334 active site 1155777002335 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1155777002336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777002338 putative substrate translocation pore; other site 1155777002339 calcium/proton exchanger (cax); Region: cax; TIGR00378 1155777002340 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1155777002341 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1155777002342 YfkD-like protein; Region: YfkD; pfam14167 1155777002343 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1155777002344 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1155777002345 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1155777002346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777002347 FeS/SAM binding site; other site 1155777002348 YfkB-like domain; Region: YfkB; pfam08756 1155777002349 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1155777002350 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1155777002351 NodB motif; other site 1155777002352 active site 1155777002353 catalytic site [active] 1155777002354 Cd binding site [ion binding]; other site 1155777002355 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777002356 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1155777002357 Walker A/P-loop; other site 1155777002358 ATP binding site [chemical binding]; other site 1155777002359 Q-loop/lid; other site 1155777002360 ABC transporter signature motif; other site 1155777002361 Walker B; other site 1155777002362 D-loop; other site 1155777002363 H-loop/switch region; other site 1155777002364 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1155777002365 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1155777002366 active site 1155777002367 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777002368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777002369 active site 1155777002370 phosphorylation site [posttranslational modification] 1155777002371 intermolecular recognition site; other site 1155777002372 dimerization interface [polypeptide binding]; other site 1155777002373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777002374 DNA binding site [nucleotide binding] 1155777002375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777002376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777002377 dimer interface [polypeptide binding]; other site 1155777002378 phosphorylation site [posttranslational modification] 1155777002379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777002380 ATP binding site [chemical binding]; other site 1155777002381 Mg2+ binding site [ion binding]; other site 1155777002382 G-X-G motif; other site 1155777002383 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1155777002384 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1155777002385 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1155777002386 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1155777002387 oligomer interface [polypeptide binding]; other site 1155777002388 metal binding site [ion binding]; metal-binding site 1155777002389 metal binding site [ion binding]; metal-binding site 1155777002390 putative Cl binding site [ion binding]; other site 1155777002391 aspartate ring; other site 1155777002392 basic sphincter; other site 1155777002393 hydrophobic gate; other site 1155777002394 periplasmic entrance; other site 1155777002395 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1155777002396 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155777002397 minor groove reading motif; other site 1155777002398 helix-hairpin-helix signature motif; other site 1155777002399 substrate binding pocket [chemical binding]; other site 1155777002400 active site 1155777002401 TRAM domain; Region: TRAM; pfam01938 1155777002402 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1155777002403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777002404 S-adenosylmethionine binding site [chemical binding]; other site 1155777002405 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1155777002406 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1155777002407 FMN binding site [chemical binding]; other site 1155777002408 active site 1155777002409 catalytic residues [active] 1155777002410 substrate binding site [chemical binding]; other site 1155777002411 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1155777002412 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1155777002413 tetramer interface [polypeptide binding]; other site 1155777002414 TPP-binding site [chemical binding]; other site 1155777002415 heterodimer interface [polypeptide binding]; other site 1155777002416 phosphorylation loop region [posttranslational modification] 1155777002417 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1155777002418 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1155777002419 alpha subunit interface [polypeptide binding]; other site 1155777002420 TPP binding site [chemical binding]; other site 1155777002421 heterodimer interface [polypeptide binding]; other site 1155777002422 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155777002423 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1155777002424 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155777002425 E3 interaction surface; other site 1155777002426 lipoyl attachment site [posttranslational modification]; other site 1155777002427 e3 binding domain; Region: E3_binding; pfam02817 1155777002428 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155777002429 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1155777002430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777002431 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155777002432 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1155777002433 GAF domain; Region: GAF; pfam01590 1155777002434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777002435 Walker A motif; other site 1155777002436 ATP binding site [chemical binding]; other site 1155777002437 Walker B motif; other site 1155777002438 arginine finger; other site 1155777002439 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1155777002440 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1155777002441 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1155777002442 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1155777002443 NAD binding site [chemical binding]; other site 1155777002444 sugar binding site [chemical binding]; other site 1155777002445 divalent metal binding site [ion binding]; other site 1155777002446 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155777002447 dimer interface [polypeptide binding]; other site 1155777002448 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155777002449 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155777002450 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155777002451 putative active site [active] 1155777002452 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1155777002453 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155777002454 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155777002455 active site turn [active] 1155777002456 phosphorylation site [posttranslational modification] 1155777002457 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155777002458 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777002459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777002460 Walker A/P-loop; other site 1155777002461 ATP binding site [chemical binding]; other site 1155777002462 Q-loop/lid; other site 1155777002463 ABC transporter signature motif; other site 1155777002464 Walker B; other site 1155777002465 D-loop; other site 1155777002466 H-loop/switch region; other site 1155777002467 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155777002468 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777002469 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155777002470 Walker A/P-loop; other site 1155777002471 ATP binding site [chemical binding]; other site 1155777002472 Q-loop/lid; other site 1155777002473 ABC transporter signature motif; other site 1155777002474 Walker B; other site 1155777002475 D-loop; other site 1155777002476 H-loop/switch region; other site 1155777002477 Predicted membrane protein [Function unknown]; Region: COG2259 1155777002478 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1155777002479 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1155777002480 putative metal binding site [ion binding]; other site 1155777002481 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155777002482 active site 1155777002483 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1155777002484 UbiA prenyltransferase family; Region: UbiA; pfam01040 1155777002485 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155777002486 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1155777002487 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1155777002488 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1155777002489 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155777002490 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1155777002491 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1155777002492 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1155777002493 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 1155777002494 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1155777002495 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1155777002496 RNAase interaction site [polypeptide binding]; other site 1155777002497 metal-dependent hydrolase; Provisional; Region: PRK13291 1155777002498 DinB superfamily; Region: DinB_2; pfam12867 1155777002499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777002501 putative substrate translocation pore; other site 1155777002502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002503 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777002504 MarR family; Region: MarR; pfam01047 1155777002505 Predicted integral membrane protein [Function unknown]; Region: COG0392 1155777002506 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1155777002507 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1155777002508 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1155777002509 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1155777002510 putative FMN binding site [chemical binding]; other site 1155777002511 YfhD-like protein; Region: YfhD; pfam14151 1155777002512 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1155777002513 TIGR01777 family protein; Region: yfcH 1155777002514 putative NAD(P) binding site [chemical binding]; other site 1155777002515 putative active site [active] 1155777002516 recombination regulator RecX; Provisional; Region: recX; PRK14135 1155777002517 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1155777002518 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777002519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002520 putative substrate translocation pore; other site 1155777002521 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1155777002522 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1155777002523 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 1155777002524 WVELL protein; Region: WVELL; pfam14043 1155777002525 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1155777002526 Bacterial SH3 domain; Region: SH3_3; cl17532 1155777002527 SdpI/YhfL protein family; Region: SdpI; pfam13630 1155777002528 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1155777002529 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155777002530 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1155777002531 Ligand binding site; other site 1155777002532 Putative Catalytic site; other site 1155777002533 DXD motif; other site 1155777002534 Predicted membrane protein [Function unknown]; Region: COG4485 1155777002535 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1155777002536 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1155777002537 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155777002538 minor groove reading motif; other site 1155777002539 helix-hairpin-helix signature motif; other site 1155777002540 substrate binding pocket [chemical binding]; other site 1155777002541 active site 1155777002542 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1155777002543 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1155777002544 DNA binding and oxoG recognition site [nucleotide binding] 1155777002545 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1155777002546 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1155777002547 putative NAD(P) binding site [chemical binding]; other site 1155777002548 active site 1155777002549 YgaB-like protein; Region: YgaB; pfam14182 1155777002550 hypothetical protein; Provisional; Region: PRK13662 1155777002551 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155777002552 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777002553 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1155777002554 Walker A/P-loop; other site 1155777002555 ATP binding site [chemical binding]; other site 1155777002556 Q-loop/lid; other site 1155777002557 ABC transporter signature motif; other site 1155777002558 Walker B; other site 1155777002559 D-loop; other site 1155777002560 H-loop/switch region; other site 1155777002561 Predicted membrane protein [Function unknown]; Region: COG4129 1155777002562 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1155777002563 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1155777002564 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777002565 inhibitor-cofactor binding pocket; inhibition site 1155777002566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777002567 catalytic residue [active] 1155777002568 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1155777002569 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1155777002570 catalytic triad [active] 1155777002571 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155777002572 metal binding site 2 [ion binding]; metal-binding site 1155777002573 putative DNA binding helix; other site 1155777002574 metal binding site 1 [ion binding]; metal-binding site 1155777002575 dimer interface [polypeptide binding]; other site 1155777002576 structural Zn2+ binding site [ion binding]; other site 1155777002577 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1155777002578 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1155777002579 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1155777002580 active site pocket [active] 1155777002581 oxyanion hole [active] 1155777002582 catalytic triad [active] 1155777002583 active site nucleophile [active] 1155777002584 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1155777002585 ThiC-associated domain; Region: ThiC-associated; pfam13667 1155777002586 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1155777002587 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1155777002588 FAD binding domain; Region: FAD_binding_4; pfam01565 1155777002589 Berberine and berberine like; Region: BBE; pfam08031 1155777002590 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1155777002591 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1155777002592 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1155777002593 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155777002594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777002595 dimer interface [polypeptide binding]; other site 1155777002596 conserved gate region; other site 1155777002597 putative PBP binding loops; other site 1155777002598 ABC-ATPase subunit interface; other site 1155777002599 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155777002600 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1155777002601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777002602 dimer interface [polypeptide binding]; other site 1155777002603 conserved gate region; other site 1155777002604 putative PBP binding loops; other site 1155777002605 ABC-ATPase subunit interface; other site 1155777002606 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155777002607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155777002608 Walker A/P-loop; other site 1155777002609 ATP binding site [chemical binding]; other site 1155777002610 Q-loop/lid; other site 1155777002611 ABC transporter signature motif; other site 1155777002612 Walker B; other site 1155777002613 D-loop; other site 1155777002614 H-loop/switch region; other site 1155777002615 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1155777002616 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1155777002617 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155777002618 Walker A/P-loop; other site 1155777002619 ATP binding site [chemical binding]; other site 1155777002620 Q-loop/lid; other site 1155777002621 ABC transporter signature motif; other site 1155777002622 Walker B; other site 1155777002623 D-loop; other site 1155777002624 H-loop/switch region; other site 1155777002625 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155777002626 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1155777002627 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1155777002628 tetramer interface [polypeptide binding]; other site 1155777002629 heme binding pocket [chemical binding]; other site 1155777002630 NADPH binding site [chemical binding]; other site 1155777002631 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1155777002632 active site 1155777002633 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1155777002634 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1155777002635 Walker A/P-loop; other site 1155777002636 ATP binding site [chemical binding]; other site 1155777002637 Q-loop/lid; other site 1155777002638 ABC transporter signature motif; other site 1155777002639 Walker B; other site 1155777002640 D-loop; other site 1155777002641 H-loop/switch region; other site 1155777002642 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1155777002643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155777002644 substrate binding pocket [chemical binding]; other site 1155777002645 membrane-bound complex binding site; other site 1155777002646 hinge residues; other site 1155777002647 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1155777002648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777002649 dimer interface [polypeptide binding]; other site 1155777002650 conserved gate region; other site 1155777002651 putative PBP binding loops; other site 1155777002652 ABC-ATPase subunit interface; other site 1155777002653 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1155777002654 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1155777002655 active site 1155777002656 dimer interface [polypeptide binding]; other site 1155777002657 non-prolyl cis peptide bond; other site 1155777002658 insertion regions; other site 1155777002659 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1155777002660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777002661 non-specific DNA binding site [nucleotide binding]; other site 1155777002662 salt bridge; other site 1155777002663 sequence-specific DNA binding site [nucleotide binding]; other site 1155777002664 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1155777002665 epoxyqueuosine reductase; Region: TIGR00276 1155777002666 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1155777002667 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1155777002668 Putative amidase domain; Region: Amidase_6; pfam12671 1155777002669 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1155777002670 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1155777002671 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1155777002672 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1155777002673 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1155777002674 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1155777002675 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1155777002676 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777002677 MarR family; Region: MarR; pfam01047 1155777002678 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1155777002679 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155777002680 carboxyltransferase (CT) interaction site; other site 1155777002681 biotinylation site [posttranslational modification]; other site 1155777002682 HlyD family secretion protein; Region: HlyD_3; pfam13437 1155777002683 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1155777002684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002685 putative substrate translocation pore; other site 1155777002686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777002687 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1155777002688 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155777002689 Predicted transcriptional regulators [Transcription]; Region: COG1725 1155777002690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777002691 DNA-binding site [nucleotide binding]; DNA binding site 1155777002692 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155777002693 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1155777002694 Walker A/P-loop; other site 1155777002695 ATP binding site [chemical binding]; other site 1155777002696 Q-loop/lid; other site 1155777002697 ABC transporter signature motif; other site 1155777002698 Walker B; other site 1155777002699 D-loop; other site 1155777002700 H-loop/switch region; other site 1155777002701 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777002702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777002703 Walker A/P-loop; other site 1155777002704 ATP binding site [chemical binding]; other site 1155777002705 Q-loop/lid; other site 1155777002706 ABC transporter signature motif; other site 1155777002707 Walker B; other site 1155777002708 D-loop; other site 1155777002709 H-loop/switch region; other site 1155777002710 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1155777002711 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155777002712 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155777002713 DNA-binding site [nucleotide binding]; DNA binding site 1155777002714 RNA-binding motif; other site 1155777002715 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1155777002716 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1155777002717 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1155777002718 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1155777002719 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1155777002720 metal binding site [ion binding]; metal-binding site 1155777002721 active site 1155777002722 I-site; other site 1155777002723 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1155777002724 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1155777002725 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1155777002726 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1155777002727 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1155777002728 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1155777002729 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1155777002730 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1155777002731 putative active site [active] 1155777002732 putative metal binding site [ion binding]; other site 1155777002733 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155777002734 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1155777002735 active site 1155777002736 catalytic site [active] 1155777002737 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1155777002738 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155777002739 active site 1155777002740 FOG: CBS domain [General function prediction only]; Region: COG0517 1155777002741 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1155777002742 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1155777002743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777002744 motif II; other site 1155777002745 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155777002746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777002747 Coenzyme A binding pocket [chemical binding]; other site 1155777002748 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1155777002749 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1155777002750 putative active site [active] 1155777002751 catalytic triad [active] 1155777002752 putative dimer interface [polypeptide binding]; other site 1155777002753 aminotransferase; Validated; Region: PRK07678 1155777002754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777002755 inhibitor-cofactor binding pocket; inhibition site 1155777002756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777002757 catalytic residue [active] 1155777002758 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1155777002759 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1155777002760 amphipathic channel; other site 1155777002761 Asn-Pro-Ala signature motifs; other site 1155777002762 glycerol kinase; Provisional; Region: glpK; PRK00047 1155777002763 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1155777002764 N- and C-terminal domain interface [polypeptide binding]; other site 1155777002765 active site 1155777002766 MgATP binding site [chemical binding]; other site 1155777002767 catalytic site [active] 1155777002768 metal binding site [ion binding]; metal-binding site 1155777002769 glycerol binding site [chemical binding]; other site 1155777002770 homotetramer interface [polypeptide binding]; other site 1155777002771 homodimer interface [polypeptide binding]; other site 1155777002772 FBP binding site [chemical binding]; other site 1155777002773 protein IIAGlc interface [polypeptide binding]; other site 1155777002774 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1155777002775 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1155777002776 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1155777002777 active site 1155777002778 substrate binding site [chemical binding]; other site 1155777002779 metal binding site [ion binding]; metal-binding site 1155777002780 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1155777002781 GAF domain; Region: GAF; pfam01590 1155777002782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1155777002783 Histidine kinase; Region: HisKA_3; pfam07730 1155777002784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777002785 ATP binding site [chemical binding]; other site 1155777002786 Mg2+ binding site [ion binding]; other site 1155777002787 G-X-G motif; other site 1155777002788 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777002789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777002790 active site 1155777002791 phosphorylation site [posttranslational modification] 1155777002792 intermolecular recognition site; other site 1155777002793 dimerization interface [polypeptide binding]; other site 1155777002794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777002795 DNA binding residues [nucleotide binding] 1155777002796 dimerization interface [polypeptide binding]; other site 1155777002797 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155777002798 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155777002799 YhdB-like protein; Region: YhdB; pfam14148 1155777002800 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1155777002801 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777002802 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777002803 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155777002804 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777002805 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777002806 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777002807 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155777002808 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155777002809 Transcriptional regulator; Region: Rrf2; cl17282 1155777002810 Rrf2 family protein; Region: rrf2_super; TIGR00738 1155777002811 Conserved TM helix; Region: TM_helix; pfam05552 1155777002812 Conserved TM helix; Region: TM_helix; pfam05552 1155777002813 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1155777002814 SpoVR like protein; Region: SpoVR; pfam04293 1155777002815 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1155777002816 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1155777002817 dimer interface [polypeptide binding]; other site 1155777002818 active site 1155777002819 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777002820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777002821 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155777002822 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155777002823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777002824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777002825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777002826 dimerization interface [polypeptide binding]; other site 1155777002827 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1155777002828 dimer interface [polypeptide binding]; other site 1155777002829 Citrate synthase; Region: Citrate_synt; pfam00285 1155777002830 active site 1155777002831 citrylCoA binding site [chemical binding]; other site 1155777002832 oxalacetate/citrate binding site [chemical binding]; other site 1155777002833 coenzyme A binding site [chemical binding]; other site 1155777002834 catalytic triad [active] 1155777002835 short chain dehydrogenase; Provisional; Region: PRK06701 1155777002836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155777002837 NAD(P) binding site [chemical binding]; other site 1155777002838 active site 1155777002839 amino acid transporter; Region: 2A0306; TIGR00909 1155777002840 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1155777002841 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1155777002842 Na2 binding site [ion binding]; other site 1155777002843 putative substrate binding site 1 [chemical binding]; other site 1155777002844 Na binding site 1 [ion binding]; other site 1155777002845 putative substrate binding site 2 [chemical binding]; other site 1155777002846 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1155777002847 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1155777002848 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1155777002849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777002850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777002851 DNA binding residues [nucleotide binding] 1155777002852 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1155777002853 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1155777002854 putative acyl-acceptor binding pocket; other site 1155777002855 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1155777002856 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155777002857 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155777002858 Transporter associated domain; Region: CorC_HlyC; smart01091 1155777002859 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1155777002860 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155777002861 DNA binding residues [nucleotide binding] 1155777002862 putative dimer interface [polypeptide binding]; other site 1155777002863 aspartate aminotransferase; Provisional; Region: PRK06836 1155777002864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777002865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777002866 homodimer interface [polypeptide binding]; other site 1155777002867 catalytic residue [active] 1155777002868 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1155777002869 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1155777002870 dimer interface [polypeptide binding]; other site 1155777002871 active site 1155777002872 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1155777002873 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155777002874 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155777002875 Transporter associated domain; Region: CorC_HlyC; smart01091 1155777002876 camphor resistance protein CrcB; Provisional; Region: PRK14213 1155777002877 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1155777002878 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155777002879 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1155777002880 active site 1155777002881 catalytic site [active] 1155777002882 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1155777002883 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1155777002884 NAD-dependent deacetylase; Provisional; Region: PRK00481 1155777002885 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1155777002886 NAD+ binding site [chemical binding]; other site 1155777002887 substrate binding site [chemical binding]; other site 1155777002888 Zn binding site [ion binding]; other site 1155777002889 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1155777002890 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1155777002891 NodB motif; other site 1155777002892 active site 1155777002893 catalytic site [active] 1155777002894 Zn binding site [ion binding]; other site 1155777002895 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1155777002896 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1155777002897 homodimer interface [polypeptide binding]; other site 1155777002898 substrate-cofactor binding pocket; other site 1155777002899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777002900 catalytic residue [active] 1155777002901 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1155777002902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777002903 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1155777002904 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155777002905 Ligand Binding Site [chemical binding]; other site 1155777002906 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155777002907 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777002908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777002909 Walker A/P-loop; other site 1155777002910 ATP binding site [chemical binding]; other site 1155777002911 Q-loop/lid; other site 1155777002912 ABC transporter signature motif; other site 1155777002913 Walker B; other site 1155777002914 D-loop; other site 1155777002915 H-loop/switch region; other site 1155777002916 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155777002917 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777002918 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1155777002919 Walker A/P-loop; other site 1155777002920 ATP binding site [chemical binding]; other site 1155777002921 Q-loop/lid; other site 1155777002922 ABC transporter signature motif; other site 1155777002923 Walker B; other site 1155777002924 D-loop; other site 1155777002925 H-loop/switch region; other site 1155777002926 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1155777002927 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1155777002928 NAD binding site [chemical binding]; other site 1155777002929 substrate binding site [chemical binding]; other site 1155777002930 putative active site [active] 1155777002931 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1155777002932 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1155777002933 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1155777002934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1155777002935 hypothetical protein; Provisional; Region: PRK13676 1155777002936 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1155777002937 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1155777002938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777002939 active site 1155777002940 motif I; other site 1155777002941 motif II; other site 1155777002942 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155777002943 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1155777002944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777002945 FeS/SAM binding site; other site 1155777002946 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1155777002947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155777002948 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1155777002949 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1155777002950 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1155777002951 TrkA-C domain; Region: TrkA_C; pfam02080 1155777002952 enoyl-CoA hydratase; Provisional; Region: PRK07659 1155777002953 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155777002954 substrate binding site [chemical binding]; other site 1155777002955 oxyanion hole (OAH) forming residues; other site 1155777002956 trimer interface [polypeptide binding]; other site 1155777002957 YhzD-like protein; Region: YhzD; pfam14120 1155777002958 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1155777002959 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1155777002960 Walker A/P-loop; other site 1155777002961 ATP binding site [chemical binding]; other site 1155777002962 Q-loop/lid; other site 1155777002963 ABC transporter signature motif; other site 1155777002964 Walker B; other site 1155777002965 D-loop; other site 1155777002966 H-loop/switch region; other site 1155777002967 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1155777002968 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1155777002969 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1155777002970 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1155777002971 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155777002972 active site 1155777002973 metal binding site [ion binding]; metal-binding site 1155777002974 DNA binding site [nucleotide binding] 1155777002975 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1155777002976 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1155777002977 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1155777002978 generic binding surface II; other site 1155777002979 generic binding surface I; other site 1155777002980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155777002981 Zn2+ binding site [ion binding]; other site 1155777002982 Mg2+ binding site [ion binding]; other site 1155777002983 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1155777002984 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1155777002985 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1155777002986 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1155777002987 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1155777002988 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1155777002989 transcriptional regulator Hpr; Provisional; Region: PRK13777 1155777002990 MarR family; Region: MarR; pfam01047 1155777002991 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1155777002992 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1155777002993 homodimer interface [polypeptide binding]; other site 1155777002994 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1155777002995 substrate-cofactor binding pocket; other site 1155777002996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777002997 catalytic residue [active] 1155777002998 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1155777002999 HIT family signature motif; other site 1155777003000 catalytic residue [active] 1155777003001 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155777003002 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155777003003 Walker A/P-loop; other site 1155777003004 ATP binding site [chemical binding]; other site 1155777003005 Q-loop/lid; other site 1155777003006 ABC transporter signature motif; other site 1155777003007 Walker B; other site 1155777003008 D-loop; other site 1155777003009 H-loop/switch region; other site 1155777003010 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1155777003011 EcsC protein family; Region: EcsC; pfam12787 1155777003012 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155777003013 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1155777003014 metal binding site [ion binding]; metal-binding site 1155777003015 dimer interface [polypeptide binding]; other site 1155777003016 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1155777003017 Transglycosylase; Region: Transgly; pfam00912 1155777003018 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1155777003019 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155777003020 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1155777003021 substrate binding site [chemical binding]; other site 1155777003022 active site 1155777003023 ferrochelatase; Provisional; Region: PRK12435 1155777003024 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1155777003025 C-terminal domain interface [polypeptide binding]; other site 1155777003026 active site 1155777003027 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1155777003028 active site 1155777003029 N-terminal domain interface [polypeptide binding]; other site 1155777003030 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1155777003031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155777003032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777003033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777003034 Predicted membrane protein [Function unknown]; Region: COG1511 1155777003035 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1155777003036 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1155777003037 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1155777003038 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1155777003039 dimer interface [polypeptide binding]; other site 1155777003040 active site 1155777003041 CoA binding pocket [chemical binding]; other site 1155777003042 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155777003043 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1155777003044 putative oligomer interface [polypeptide binding]; other site 1155777003045 putative active site [active] 1155777003046 metal binding site [ion binding]; metal-binding site 1155777003047 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1155777003048 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1155777003049 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1155777003050 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155777003051 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1155777003052 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1155777003053 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1155777003054 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1155777003055 NAD(P) binding site [chemical binding]; other site 1155777003056 putative active site [active] 1155777003057 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1155777003058 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1155777003059 acyl-activating enzyme (AAE) consensus motif; other site 1155777003060 putative AMP binding site [chemical binding]; other site 1155777003061 putative active site [active] 1155777003062 putative CoA binding site [chemical binding]; other site 1155777003063 Peptidase family M48; Region: Peptidase_M48; pfam01435 1155777003064 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1155777003065 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1155777003066 active site 1155777003067 catalytic residues [active] 1155777003068 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1155777003069 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1155777003070 siderophore binding site; other site 1155777003071 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155777003072 catalytic core [active] 1155777003073 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1155777003074 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1155777003075 dimer interface [polypeptide binding]; other site 1155777003076 active site 1155777003077 acyl-CoA synthetase; Validated; Region: PRK07638 1155777003078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1155777003079 acyl-activating enzyme (AAE) consensus motif; other site 1155777003080 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1155777003081 acyl-activating enzyme (AAE) consensus motif; other site 1155777003082 AMP binding site [chemical binding]; other site 1155777003083 active site 1155777003084 CoA binding site [chemical binding]; other site 1155777003085 BioY family; Region: BioY; pfam02632 1155777003086 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1155777003087 heme-binding site [chemical binding]; other site 1155777003088 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1155777003089 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777003090 dimer interface [polypeptide binding]; other site 1155777003091 putative CheW interface [polypeptide binding]; other site 1155777003092 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1155777003093 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1155777003094 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1155777003095 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1155777003096 [2Fe-2S] cluster binding site [ion binding]; other site 1155777003097 short chain dehydrogenase; Provisional; Region: PRK06701 1155777003098 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1155777003099 NAD binding site [chemical binding]; other site 1155777003100 metal binding site [ion binding]; metal-binding site 1155777003101 active site 1155777003102 A short protein domain of unknown function; Region: IDEAL; smart00914 1155777003103 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1155777003104 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1155777003105 MepB protein; Region: MepB; pfam08877 1155777003106 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1155777003107 putative binding site; other site 1155777003108 putative dimer interface [polypeptide binding]; other site 1155777003109 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1155777003110 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1155777003111 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1155777003112 Na binding site [ion binding]; other site 1155777003113 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1155777003114 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1155777003115 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155777003116 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155777003117 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155777003118 Catalytic site [active] 1155777003119 hypothetical protein; Provisional; Region: PRK08244 1155777003120 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1155777003121 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777003122 MarR family; Region: MarR; pfam01047 1155777003123 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1155777003124 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1155777003125 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1155777003126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777003127 putative substrate translocation pore; other site 1155777003128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777003129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777003130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777003131 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1155777003132 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1155777003133 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1155777003134 dinuclear metal binding motif [ion binding]; other site 1155777003135 Predicted membrane protein [Function unknown]; Region: COG2323 1155777003136 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1155777003137 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1155777003138 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1155777003139 Part of AAA domain; Region: AAA_19; pfam13245 1155777003140 Family description; Region: UvrD_C_2; pfam13538 1155777003141 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1155777003142 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1155777003143 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1155777003144 active site 1155777003145 metal binding site [ion binding]; metal-binding site 1155777003146 DNA binding site [nucleotide binding] 1155777003147 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1155777003148 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1155777003149 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1155777003150 Walker A/P-loop; other site 1155777003151 ATP binding site [chemical binding]; other site 1155777003152 Q-loop/lid; other site 1155777003153 ABC transporter signature motif; other site 1155777003154 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1155777003155 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1155777003156 ABC transporter signature motif; other site 1155777003157 Walker B; other site 1155777003158 D-loop; other site 1155777003159 H-loop/switch region; other site 1155777003160 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1155777003161 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1155777003162 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1155777003163 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1155777003164 Spore germination protein GerPC; Region: GerPC; pfam10737 1155777003165 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1155777003166 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1155777003167 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1155777003168 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1155777003169 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1155777003170 hypothetical protein; Provisional; Region: PRK13673 1155777003171 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1155777003172 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1155777003173 active site 1155777003174 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1155777003175 dimer interface [polypeptide binding]; other site 1155777003176 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1155777003177 Ligand Binding Site [chemical binding]; other site 1155777003178 Molecular Tunnel; other site 1155777003179 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1155777003180 substrate binding pocket [chemical binding]; other site 1155777003181 substrate-Mg2+ binding site; other site 1155777003182 aspartate-rich region 1; other site 1155777003183 aspartate-rich region 2; other site 1155777003184 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1155777003185 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1155777003186 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1155777003187 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1155777003188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777003189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777003190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777003191 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777003192 DNA binding site [nucleotide binding] 1155777003193 domain linker motif; other site 1155777003194 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155777003195 dimerization interface [polypeptide binding]; other site 1155777003196 ligand binding site [chemical binding]; other site 1155777003197 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155777003198 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155777003199 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155777003200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1155777003201 DinB superfamily; Region: DinB_2; pfam12867 1155777003202 Lysine efflux permease [General function prediction only]; Region: COG1279 1155777003203 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155777003204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777003205 DNA-binding site [nucleotide binding]; DNA binding site 1155777003206 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777003207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777003208 homodimer interface [polypeptide binding]; other site 1155777003209 catalytic residue [active] 1155777003210 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1155777003211 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1155777003212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1155777003213 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1155777003214 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1155777003215 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1155777003216 FAD binding site [chemical binding]; other site 1155777003217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1155777003218 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1155777003219 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1155777003220 S1 domain; Region: S1_2; pfam13509 1155777003221 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1155777003222 RNA binding site [nucleotide binding]; other site 1155777003223 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1155777003224 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1155777003225 ligand binding site [chemical binding]; other site 1155777003226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777003227 dimerization interface [polypeptide binding]; other site 1155777003228 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1155777003229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777003230 dimer interface [polypeptide binding]; other site 1155777003231 putative CheW interface [polypeptide binding]; other site 1155777003232 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1155777003233 Cytochrome P450; Region: p450; cl12078 1155777003234 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155777003235 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155777003236 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155777003237 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777003238 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777003239 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155777003240 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1155777003241 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1155777003242 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155777003243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777003244 motif II; other site 1155777003245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777003246 esterase; Provisional; Region: PRK10566 1155777003247 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1155777003248 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1155777003249 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155777003250 active site 1155777003251 metal binding site [ion binding]; metal-binding site 1155777003252 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1155777003253 FAD binding domain; Region: FAD_binding_4; pfam01565 1155777003254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777003255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777003256 putative substrate translocation pore; other site 1155777003257 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1155777003258 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1155777003259 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1155777003260 heterotetramer interface [polypeptide binding]; other site 1155777003261 active site pocket [active] 1155777003262 cleavage site 1155777003263 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1155777003264 nucleotide binding site [chemical binding]; other site 1155777003265 N-acetyl-L-glutamate binding site [chemical binding]; other site 1155777003266 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1155777003267 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777003268 inhibitor-cofactor binding pocket; inhibition site 1155777003269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777003270 catalytic residue [active] 1155777003271 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1155777003272 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1155777003273 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1155777003274 catalytic site [active] 1155777003275 subunit interface [polypeptide binding]; other site 1155777003276 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1155777003277 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155777003278 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155777003279 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1155777003280 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155777003281 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155777003282 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1155777003283 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155777003284 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155777003285 YjzC-like protein; Region: YjzC; pfam14168 1155777003286 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1155777003287 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1155777003288 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1155777003289 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1155777003290 putative ligand binding site [chemical binding]; other site 1155777003291 ComZ; Region: ComZ; pfam10815 1155777003292 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1155777003293 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1155777003294 dimer interface [polypeptide binding]; other site 1155777003295 active site 1155777003296 CoA binding pocket [chemical binding]; other site 1155777003297 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1155777003298 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1155777003299 dimer interface [polypeptide binding]; other site 1155777003300 active site 1155777003301 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1155777003302 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155777003303 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155777003304 Walker A/P-loop; other site 1155777003305 ATP binding site [chemical binding]; other site 1155777003306 Q-loop/lid; other site 1155777003307 ABC transporter signature motif; other site 1155777003308 Walker B; other site 1155777003309 D-loop; other site 1155777003310 H-loop/switch region; other site 1155777003311 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1155777003312 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1155777003313 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155777003314 Walker A/P-loop; other site 1155777003315 ATP binding site [chemical binding]; other site 1155777003316 Q-loop/lid; other site 1155777003317 ABC transporter signature motif; other site 1155777003318 Walker B; other site 1155777003319 D-loop; other site 1155777003320 H-loop/switch region; other site 1155777003321 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1155777003322 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1155777003323 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1155777003324 peptide binding site [polypeptide binding]; other site 1155777003325 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155777003326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777003327 dimer interface [polypeptide binding]; other site 1155777003328 conserved gate region; other site 1155777003329 putative PBP binding loops; other site 1155777003330 ABC-ATPase subunit interface; other site 1155777003331 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155777003332 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1155777003333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777003334 dimer interface [polypeptide binding]; other site 1155777003335 conserved gate region; other site 1155777003336 putative PBP binding loops; other site 1155777003337 ABC-ATPase subunit interface; other site 1155777003338 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1155777003339 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1155777003340 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1155777003341 active site 1155777003342 HIGH motif; other site 1155777003343 dimer interface [polypeptide binding]; other site 1155777003344 KMSKS motif; other site 1155777003345 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1155777003346 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1155777003347 peptide binding site [polypeptide binding]; other site 1155777003348 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1155777003349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777003350 dimer interface [polypeptide binding]; other site 1155777003351 conserved gate region; other site 1155777003352 putative PBP binding loops; other site 1155777003353 ABC-ATPase subunit interface; other site 1155777003354 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155777003355 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1155777003356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777003357 dimer interface [polypeptide binding]; other site 1155777003358 conserved gate region; other site 1155777003359 putative PBP binding loops; other site 1155777003360 ABC-ATPase subunit interface; other site 1155777003361 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155777003362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155777003363 Walker A/P-loop; other site 1155777003364 ATP binding site [chemical binding]; other site 1155777003365 Q-loop/lid; other site 1155777003366 ABC transporter signature motif; other site 1155777003367 Walker B; other site 1155777003368 D-loop; other site 1155777003369 H-loop/switch region; other site 1155777003370 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155777003371 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1155777003372 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155777003373 Walker A/P-loop; other site 1155777003374 ATP binding site [chemical binding]; other site 1155777003375 Q-loop/lid; other site 1155777003376 ABC transporter signature motif; other site 1155777003377 Walker B; other site 1155777003378 D-loop; other site 1155777003379 H-loop/switch region; other site 1155777003380 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1155777003381 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1155777003382 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1155777003383 Coenzyme A binding pocket [chemical binding]; other site 1155777003384 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155777003385 ArsC family; Region: ArsC; pfam03960 1155777003386 putative catalytic residues [active] 1155777003387 thiol/disulfide switch; other site 1155777003388 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1155777003389 adaptor protein; Provisional; Region: PRK02315 1155777003390 Competence protein CoiA-like family; Region: CoiA; cl11541 1155777003391 oligoendopeptidase F; Region: pepF; TIGR00181 1155777003392 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1155777003393 active site 1155777003394 Zn binding site [ion binding]; other site 1155777003395 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1155777003396 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1155777003397 catalytic residues [active] 1155777003398 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1155777003399 apolar tunnel; other site 1155777003400 heme binding site [chemical binding]; other site 1155777003401 dimerization interface [polypeptide binding]; other site 1155777003402 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1155777003403 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155777003404 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155777003405 catalytic residue [active] 1155777003406 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1155777003407 putative active site [active] 1155777003408 putative metal binding residues [ion binding]; other site 1155777003409 signature motif; other site 1155777003410 putative triphosphate binding site [ion binding]; other site 1155777003411 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155777003412 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1155777003413 synthetase active site [active] 1155777003414 NTP binding site [chemical binding]; other site 1155777003415 metal binding site [ion binding]; metal-binding site 1155777003416 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1155777003417 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1155777003418 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155777003419 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155777003420 active site 1155777003421 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1155777003422 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1155777003423 active site 1155777003424 metal binding site [ion binding]; metal-binding site 1155777003425 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1155777003426 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1155777003427 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1155777003428 TrkA-N domain; Region: TrkA_N; pfam02254 1155777003429 TrkA-C domain; Region: TrkA_C; pfam02080 1155777003430 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1155777003431 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1155777003432 thiamine phosphate binding site [chemical binding]; other site 1155777003433 active site 1155777003434 pyrophosphate binding site [ion binding]; other site 1155777003435 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1155777003436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155777003437 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1155777003438 thiS-thiF/thiG interaction site; other site 1155777003439 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1155777003440 ThiS interaction site; other site 1155777003441 putative active site [active] 1155777003442 tetramer interface [polypeptide binding]; other site 1155777003443 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1155777003444 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1155777003445 ATP binding site [chemical binding]; other site 1155777003446 substrate interface [chemical binding]; other site 1155777003447 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1155777003448 dimer interface [polypeptide binding]; other site 1155777003449 substrate binding site [chemical binding]; other site 1155777003450 ATP binding site [chemical binding]; other site 1155777003451 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1155777003452 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1155777003453 NAD binding site [chemical binding]; other site 1155777003454 homotetramer interface [polypeptide binding]; other site 1155777003455 homodimer interface [polypeptide binding]; other site 1155777003456 substrate binding site [chemical binding]; other site 1155777003457 active site 1155777003458 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1155777003459 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1155777003460 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1155777003461 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1155777003462 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1155777003463 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1155777003464 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1155777003465 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1155777003466 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1155777003467 Part of AAA domain; Region: AAA_19; pfam13245 1155777003468 Family description; Region: UvrD_C_2; pfam13538 1155777003469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155777003470 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155777003471 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1155777003472 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155777003473 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1155777003474 Walker A/P-loop; other site 1155777003475 ATP binding site [chemical binding]; other site 1155777003476 Q-loop/lid; other site 1155777003477 ABC transporter signature motif; other site 1155777003478 Walker B; other site 1155777003479 D-loop; other site 1155777003480 H-loop/switch region; other site 1155777003481 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1155777003482 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1155777003483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155777003484 Coenzyme A binding pocket [chemical binding]; other site 1155777003485 hypothetical protein; Provisional; Region: PRK13679 1155777003486 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1155777003487 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1155777003488 Putative esterase; Region: Esterase; pfam00756 1155777003489 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1155777003490 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1155777003491 homodimer interface [polypeptide binding]; other site 1155777003492 substrate-cofactor binding pocket; other site 1155777003493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777003494 catalytic residue [active] 1155777003495 cystathionine beta-lyase; Provisional; Region: PRK08064 1155777003496 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1155777003497 homodimer interface [polypeptide binding]; other site 1155777003498 substrate-cofactor binding pocket; other site 1155777003499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777003500 catalytic residue [active] 1155777003501 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155777003502 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1155777003503 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155777003504 Int/Topo IB signature motif; other site 1155777003505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155777003506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777003507 non-specific DNA binding site [nucleotide binding]; other site 1155777003508 salt bridge; other site 1155777003509 sequence-specific DNA binding site [nucleotide binding]; other site 1155777003510 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1155777003511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777003512 non-specific DNA binding site [nucleotide binding]; other site 1155777003513 sequence-specific DNA binding site [nucleotide binding]; other site 1155777003514 salt bridge; other site 1155777003515 Homeodomain-like domain; Region: HTH_23; pfam13384 1155777003516 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1155777003517 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1155777003518 catalytic residues [active] 1155777003519 catalytic nucleophile [active] 1155777003520 Presynaptic Site I dimer interface [polypeptide binding]; other site 1155777003521 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1155777003522 Synaptic Flat tetramer interface [polypeptide binding]; other site 1155777003523 Synaptic Site I dimer interface [polypeptide binding]; other site 1155777003524 DNA binding site [nucleotide binding] 1155777003525 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1155777003526 DNA-binding interface [nucleotide binding]; DNA binding site 1155777003527 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1155777003528 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1155777003529 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1155777003530 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 1155777003531 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1155777003532 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1155777003533 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155777003534 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155777003535 catalytic residue [active] 1155777003536 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155777003537 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155777003538 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155777003539 sodium/calcium exchanger 1; Region: caca; TIGR00845 1155777003540 LXG domain of WXG superfamily; Region: LXG; pfam04740 1155777003541 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155777003542 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1155777003543 nucleotide binding site/active site [active] 1155777003544 HIT family signature motif; other site 1155777003545 catalytic residue [active] 1155777003546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777003547 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1155777003548 active site 1155777003549 metal binding site [ion binding]; metal-binding site 1155777003550 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1155777003551 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1155777003552 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1155777003553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777003554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777003555 putative substrate translocation pore; other site 1155777003556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777003557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777003558 putative Zn2+ binding site [ion binding]; other site 1155777003559 putative DNA binding site [nucleotide binding]; other site 1155777003560 dimerization interface [polypeptide binding]; other site 1155777003561 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1155777003562 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1155777003563 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1155777003564 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1155777003565 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1155777003566 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1155777003567 NAD binding site [chemical binding]; other site 1155777003568 homodimer interface [polypeptide binding]; other site 1155777003569 active site 1155777003570 substrate binding site [chemical binding]; other site 1155777003571 galactokinase; Provisional; Region: PRK05322 1155777003572 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1155777003573 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155777003574 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155777003575 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1155777003576 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1155777003577 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1155777003578 active site 1155777003579 P-loop; other site 1155777003580 phosphorylation site [posttranslational modification] 1155777003581 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155777003582 methionine cluster; other site 1155777003583 active site 1155777003584 phosphorylation site [posttranslational modification] 1155777003585 metal binding site [ion binding]; metal-binding site 1155777003586 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1155777003587 beta-galactosidase; Region: BGL; TIGR03356 1155777003588 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155777003589 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1155777003590 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155777003591 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1155777003592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777003593 motif II; other site 1155777003594 hypothetical protein; Provisional; Region: PRK09272 1155777003595 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777003596 MarR family; Region: MarR; pfam01047 1155777003597 MgtC family; Region: MgtC; pfam02308 1155777003598 Putative motility protein; Region: YjfB_motility; pfam14070 1155777003599 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1155777003600 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1155777003601 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1155777003602 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1155777003603 catalytic loop [active] 1155777003604 iron binding site [ion binding]; other site 1155777003605 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 1155777003606 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1155777003607 4Fe-4S binding domain; Region: Fer4; pfam00037 1155777003608 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1155777003609 [4Fe-4S] binding site [ion binding]; other site 1155777003610 molybdopterin cofactor binding site; other site 1155777003611 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1155777003612 molybdopterin cofactor binding site; other site 1155777003613 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1155777003614 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1155777003615 Cytochrome P450; Region: p450; cl12078 1155777003616 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1155777003617 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1155777003618 active site 1155777003619 TDP-binding site; other site 1155777003620 acceptor substrate-binding pocket; other site 1155777003621 homodimer interface [polypeptide binding]; other site 1155777003622 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1155777003623 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1155777003624 active site 1155777003625 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1155777003626 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1155777003627 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1155777003628 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1155777003629 Walker A/P-loop; other site 1155777003630 ATP binding site [chemical binding]; other site 1155777003631 Q-loop/lid; other site 1155777003632 ABC transporter signature motif; other site 1155777003633 Walker B; other site 1155777003634 D-loop; other site 1155777003635 H-loop/switch region; other site 1155777003636 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1155777003637 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1155777003638 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1155777003639 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1155777003640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777003641 Glucuronate isomerase; Region: UxaC; pfam02614 1155777003642 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1155777003643 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1155777003644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777003645 putative substrate translocation pore; other site 1155777003646 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777003647 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777003648 DNA binding site [nucleotide binding] 1155777003649 domain linker motif; other site 1155777003650 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155777003651 dimerization interface [polypeptide binding]; other site 1155777003652 ligand binding site [chemical binding]; other site 1155777003653 altronate oxidoreductase; Provisional; Region: PRK03643 1155777003654 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1155777003655 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1155777003656 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1155777003657 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1155777003658 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1155777003659 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1155777003660 DinB family; Region: DinB; cl17821 1155777003661 DinB superfamily; Region: DinB_2; pfam12867 1155777003662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777003663 binding surface 1155777003664 TPR motif; other site 1155777003665 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777003666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1155777003667 binding surface 1155777003668 TPR motif; other site 1155777003669 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1155777003670 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155777003671 amidase catalytic site [active] 1155777003672 Zn binding residues [ion binding]; other site 1155777003673 substrate binding site [chemical binding]; other site 1155777003674 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155777003675 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777003676 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1155777003677 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155777003678 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1155777003679 pentamer interface [polypeptide binding]; other site 1155777003680 dodecaamer interface [polypeptide binding]; other site 1155777003681 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1155777003682 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1155777003683 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155777003684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777003685 non-specific DNA binding site [nucleotide binding]; other site 1155777003686 salt bridge; other site 1155777003687 sequence-specific DNA binding site [nucleotide binding]; other site 1155777003688 hypothetical protein; Provisional; Region: PRK06921 1155777003689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777003690 Walker A motif; other site 1155777003691 ATP binding site [chemical binding]; other site 1155777003692 Walker B motif; other site 1155777003693 positive control sigma-like factor; Validated; Region: PRK06930 1155777003694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777003695 DNA binding residues [nucleotide binding] 1155777003696 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1155777003697 Terminase small subunit; Region: Terminase_2; cl01513 1155777003698 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 1155777003699 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1155777003700 Haemolysin XhlA; Region: XhlA; pfam10779 1155777003701 Phage lysis protein, holin; Region: Phage_holin; pfam04688 1155777003702 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155777003703 amidase catalytic site [active] 1155777003704 Zn binding residues [ion binding]; other site 1155777003705 substrate binding site [chemical binding]; other site 1155777003706 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777003707 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1155777003708 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155777003709 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1155777003710 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1155777003711 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1155777003712 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1155777003713 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1155777003714 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1155777003715 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777003716 Zn binding site [ion binding]; other site 1155777003717 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1155777003718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777003719 Zn binding site [ion binding]; other site 1155777003720 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1155777003721 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1155777003722 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1155777003723 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1155777003724 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1155777003725 Ligand binding site; other site 1155777003726 Putative Catalytic site; other site 1155777003727 DXD motif; other site 1155777003728 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1155777003729 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1155777003730 protein binding site [polypeptide binding]; other site 1155777003731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777003732 putative substrate translocation pore; other site 1155777003733 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1155777003734 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1155777003735 SxDxEG motif; other site 1155777003736 active site 1155777003737 metal binding site [ion binding]; metal-binding site 1155777003738 homopentamer interface [polypeptide binding]; other site 1155777003739 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155777003740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777003741 dimer interface [polypeptide binding]; other site 1155777003742 conserved gate region; other site 1155777003743 putative PBP binding loops; other site 1155777003744 ABC-ATPase subunit interface; other site 1155777003745 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155777003746 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1155777003747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777003748 dimer interface [polypeptide binding]; other site 1155777003749 conserved gate region; other site 1155777003750 putative PBP binding loops; other site 1155777003751 ABC-ATPase subunit interface; other site 1155777003752 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155777003753 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155777003754 Walker A/P-loop; other site 1155777003755 ATP binding site [chemical binding]; other site 1155777003756 Q-loop/lid; other site 1155777003757 ABC transporter signature motif; other site 1155777003758 Walker B; other site 1155777003759 D-loop; other site 1155777003760 H-loop/switch region; other site 1155777003761 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155777003762 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1155777003763 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1155777003764 peptide binding site [polypeptide binding]; other site 1155777003765 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1155777003766 dimer interface [polypeptide binding]; other site 1155777003767 catalytic triad [active] 1155777003768 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1155777003769 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1155777003770 active site 1155777003771 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155777003772 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155777003773 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1155777003774 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155777003775 Walker A/P-loop; other site 1155777003776 ATP binding site [chemical binding]; other site 1155777003777 Q-loop/lid; other site 1155777003778 ABC transporter signature motif; other site 1155777003779 Walker B; other site 1155777003780 D-loop; other site 1155777003781 H-loop/switch region; other site 1155777003782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155777003783 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1155777003784 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1155777003785 Amidinotransferase; Region: Amidinotransf; pfam02274 1155777003786 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1155777003787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155777003788 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155777003789 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1155777003790 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1155777003791 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1155777003792 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1155777003793 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1155777003794 putative active site [active] 1155777003795 putative substrate binding site [chemical binding]; other site 1155777003796 putative cosubstrate binding site; other site 1155777003797 catalytic site [active] 1155777003798 gamma-glutamyl kinase; Provisional; Region: PRK05429 1155777003799 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1155777003800 nucleotide binding site [chemical binding]; other site 1155777003801 homotetrameric interface [polypeptide binding]; other site 1155777003802 putative phosphate binding site [ion binding]; other site 1155777003803 putative allosteric binding site; other site 1155777003804 PUA domain; Region: PUA; pfam01472 1155777003805 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1155777003806 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1155777003807 putative catalytic cysteine [active] 1155777003808 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1155777003809 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155777003810 MarR family; Region: MarR; pfam01047 1155777003811 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1155777003812 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155777003813 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1155777003814 putative metal binding site; other site 1155777003815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777003816 binding surface 1155777003817 TPR motif; other site 1155777003818 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1155777003819 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1155777003820 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1155777003821 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1155777003822 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1155777003823 ligand binding site [chemical binding]; other site 1155777003824 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1155777003825 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1155777003826 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1155777003827 THF binding site; other site 1155777003828 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1155777003829 substrate binding site [chemical binding]; other site 1155777003830 THF binding site; other site 1155777003831 zinc-binding site [ion binding]; other site 1155777003832 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1155777003833 active site 1155777003834 catalytic residues [active] 1155777003835 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1155777003836 Cobalt transport protein; Region: CbiQ; pfam02361 1155777003837 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1155777003838 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155777003839 Walker A/P-loop; other site 1155777003840 ATP binding site [chemical binding]; other site 1155777003841 Q-loop/lid; other site 1155777003842 ABC transporter signature motif; other site 1155777003843 Walker B; other site 1155777003844 D-loop; other site 1155777003845 H-loop/switch region; other site 1155777003846 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155777003847 Walker A/P-loop; other site 1155777003848 ATP binding site [chemical binding]; other site 1155777003849 Q-loop/lid; other site 1155777003850 ABC transporter signature motif; other site 1155777003851 Walker B; other site 1155777003852 D-loop; other site 1155777003853 H-loop/switch region; other site 1155777003854 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1155777003855 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1155777003856 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777003857 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777003858 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1155777003859 active site 1155777003860 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1155777003861 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1155777003862 MgtE intracellular N domain; Region: MgtE_N; smart00924 1155777003863 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1155777003864 Divalent cation transporter; Region: MgtE; pfam01769 1155777003865 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1155777003866 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155777003867 DNA binding residues [nucleotide binding] 1155777003868 putative dimer interface [polypeptide binding]; other site 1155777003869 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777003870 MarR family; Region: MarR; pfam01047 1155777003871 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1155777003872 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1155777003873 active site 1155777003874 DNA binding site [nucleotide binding] 1155777003875 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1155777003876 nucleotide binding site [chemical binding]; other site 1155777003877 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1155777003878 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1155777003879 putative DNA binding site [nucleotide binding]; other site 1155777003880 putative homodimer interface [polypeptide binding]; other site 1155777003881 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1155777003882 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155777003883 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1155777003884 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1155777003885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777003886 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1155777003887 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1155777003888 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1155777003889 heat shock protein HtpX; Provisional; Region: PRK05457 1155777003890 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1155777003891 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1155777003892 Predicted membrane protein [Function unknown]; Region: COG2323 1155777003893 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1155777003894 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1155777003895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777003896 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1155777003897 putative active site [active] 1155777003898 heme pocket [chemical binding]; other site 1155777003899 PAS domain; Region: PAS; smart00091 1155777003900 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1155777003901 PAS domain; Region: PAS; smart00091 1155777003902 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1155777003903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777003904 dimer interface [polypeptide binding]; other site 1155777003905 phosphorylation site [posttranslational modification] 1155777003906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777003907 ATP binding site [chemical binding]; other site 1155777003908 Mg2+ binding site [ion binding]; other site 1155777003909 G-X-G motif; other site 1155777003910 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1155777003911 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1155777003912 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1155777003913 DNA binding site [nucleotide binding] 1155777003914 active site 1155777003915 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1155777003916 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1155777003917 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1155777003918 Phosphotransferase enzyme family; Region: APH; pfam01636 1155777003919 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1155777003920 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1155777003921 putative active site [active] 1155777003922 catalytic triad [active] 1155777003923 putative dimer interface [polypeptide binding]; other site 1155777003924 transaminase; Reviewed; Region: PRK08068 1155777003925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777003926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777003927 homodimer interface [polypeptide binding]; other site 1155777003928 catalytic residue [active] 1155777003929 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1155777003930 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1155777003931 dimer interface [polypeptide binding]; other site 1155777003932 active site 1155777003933 catalytic residue [active] 1155777003934 metal binding site [ion binding]; metal-binding site 1155777003935 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1155777003936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777003937 motif II; other site 1155777003938 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1155777003939 intersubunit interface [polypeptide binding]; other site 1155777003940 active site 1155777003941 Zn2+ binding site [ion binding]; other site 1155777003942 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1155777003943 Cupin domain; Region: Cupin_2; pfam07883 1155777003944 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1155777003945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777003946 dimer interface [polypeptide binding]; other site 1155777003947 phosphorylation site [posttranslational modification] 1155777003948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777003949 ATP binding site [chemical binding]; other site 1155777003950 Mg2+ binding site [ion binding]; other site 1155777003951 G-X-G motif; other site 1155777003952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777003953 MarR family; Region: MarR; pfam01047 1155777003954 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1155777003955 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1155777003956 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1155777003957 ligand binding site [chemical binding]; other site 1155777003958 flagellar motor protein MotA; Validated; Region: PRK08124 1155777003959 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1155777003960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777003961 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155777003962 Walker A motif; other site 1155777003963 ATP binding site [chemical binding]; other site 1155777003964 Walker B motif; other site 1155777003965 arginine finger; other site 1155777003966 UvrB/uvrC motif; Region: UVR; pfam02151 1155777003967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777003968 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155777003969 Walker A motif; other site 1155777003970 ATP binding site [chemical binding]; other site 1155777003971 Walker B motif; other site 1155777003972 arginine finger; other site 1155777003973 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155777003974 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1155777003975 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1155777003976 Ligand Binding Site [chemical binding]; other site 1155777003977 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1155777003978 active site 1155777003979 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1155777003980 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1155777003981 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1155777003982 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155777003983 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155777003984 short chain dehydrogenase; Provisional; Region: PRK06500 1155777003985 classical (c) SDRs; Region: SDR_c; cd05233 1155777003986 NAD(P) binding site [chemical binding]; other site 1155777003987 active site 1155777003988 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1155777003989 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1155777003990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1155777003991 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1155777003992 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1155777003993 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155777003994 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1155777003995 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155777003996 catalytic residues [active] 1155777003997 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1155777003998 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155777003999 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155777004000 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1155777004001 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1155777004002 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1155777004003 active site 1155777004004 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777004005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777004006 DNA binding site [nucleotide binding] 1155777004007 domain linker motif; other site 1155777004008 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1155777004009 putative dimerization interface [polypeptide binding]; other site 1155777004010 putative ligand binding site [chemical binding]; other site 1155777004011 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1155777004012 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155777004013 PRD domain; Region: PRD; pfam00874 1155777004014 PRD domain; Region: PRD; pfam00874 1155777004015 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1155777004016 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155777004017 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155777004018 active site turn [active] 1155777004019 phosphorylation site [posttranslational modification] 1155777004020 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1155777004021 HPr interaction site; other site 1155777004022 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155777004023 active site 1155777004024 phosphorylation site [posttranslational modification] 1155777004025 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1155777004026 dimerization domain swap beta strand [polypeptide binding]; other site 1155777004027 regulatory protein interface [polypeptide binding]; other site 1155777004028 active site 1155777004029 regulatory phosphorylation site [posttranslational modification]; other site 1155777004030 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1155777004031 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1155777004032 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1155777004033 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1155777004034 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1155777004035 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1155777004036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777004037 FeS/SAM binding site; other site 1155777004038 Cache domain; Region: Cache_1; pfam02743 1155777004039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777004040 dimerization interface [polypeptide binding]; other site 1155777004041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777004042 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1155777004043 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777004044 dimer interface [polypeptide binding]; other site 1155777004045 putative CheW interface [polypeptide binding]; other site 1155777004046 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1155777004047 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1155777004048 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1155777004049 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1155777004050 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155777004051 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155777004052 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155777004053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155777004054 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1155777004055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777004056 putative active site [active] 1155777004057 heme pocket [chemical binding]; other site 1155777004058 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1155777004059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777004060 putative active site [active] 1155777004061 heme pocket [chemical binding]; other site 1155777004062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777004063 putative active site [active] 1155777004064 heme pocket [chemical binding]; other site 1155777004065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1155777004066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777004067 dimer interface [polypeptide binding]; other site 1155777004068 phosphorylation site [posttranslational modification] 1155777004069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777004070 ATP binding site [chemical binding]; other site 1155777004071 Mg2+ binding site [ion binding]; other site 1155777004072 G-X-G motif; other site 1155777004073 aminotransferase A; Validated; Region: PRK07683 1155777004074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777004075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777004076 homodimer interface [polypeptide binding]; other site 1155777004077 catalytic residue [active] 1155777004078 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1155777004079 putative CheA interaction surface; other site 1155777004080 Response regulator receiver domain; Region: Response_reg; pfam00072 1155777004081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777004082 active site 1155777004083 phosphorylation site [posttranslational modification] 1155777004084 intermolecular recognition site; other site 1155777004085 dimerization interface [polypeptide binding]; other site 1155777004086 YkyB-like protein; Region: YkyB; pfam14177 1155777004087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777004088 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155777004089 putative substrate translocation pore; other site 1155777004090 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777004091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1155777004092 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1155777004093 phosphodiesterase YaeI; Provisional; Region: PRK11340 1155777004094 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1155777004095 putative active site [active] 1155777004096 putative metal binding site [ion binding]; other site 1155777004097 short chain dehydrogenase; Provisional; Region: PRK07677 1155777004098 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1155777004099 NAD(P) binding site [chemical binding]; other site 1155777004100 substrate binding site [chemical binding]; other site 1155777004101 homotetramer interface [polypeptide binding]; other site 1155777004102 active site 1155777004103 homodimer interface [polypeptide binding]; other site 1155777004104 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1155777004105 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1155777004106 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1155777004107 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1155777004108 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1155777004109 FOG: CBS domain [General function prediction only]; Region: COG0517 1155777004110 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1155777004111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777004112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777004113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777004114 dimerization interface [polypeptide binding]; other site 1155777004115 flavodoxin; Provisional; Region: PRK06703 1155777004116 BNR repeat-like domain; Region: BNR_2; pfam13088 1155777004117 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1155777004118 flavodoxin, short chain; Region: flav_short; TIGR01753 1155777004119 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1155777004120 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1155777004121 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1155777004122 active site 1155777004123 trimer interface [polypeptide binding]; other site 1155777004124 substrate binding site [chemical binding]; other site 1155777004125 CoA binding site [chemical binding]; other site 1155777004126 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155777004127 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1155777004128 metal binding site [ion binding]; metal-binding site 1155777004129 hypothetical protein; Provisional; Region: PRK03094 1155777004130 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1155777004131 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1155777004132 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1155777004133 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155777004134 catalytic residues [active] 1155777004135 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1155777004136 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1155777004137 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1155777004138 GTP binding site; other site 1155777004139 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1155777004140 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1155777004141 ATP binding site [chemical binding]; other site 1155777004142 substrate interface [chemical binding]; other site 1155777004143 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1155777004144 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1155777004145 dimer interface [polypeptide binding]; other site 1155777004146 putative functional site; other site 1155777004147 putative MPT binding site; other site 1155777004148 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1155777004149 Walker A motif; other site 1155777004150 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1155777004151 MoaE homodimer interface [polypeptide binding]; other site 1155777004152 MoaD interaction [polypeptide binding]; other site 1155777004153 active site residues [active] 1155777004154 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1155777004155 MoaE interaction surface [polypeptide binding]; other site 1155777004156 MoeB interaction surface [polypeptide binding]; other site 1155777004157 thiocarboxylated glycine; other site 1155777004158 Yip1 domain; Region: Yip1; pfam04893 1155777004159 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1155777004160 HlyD family secretion protein; Region: HlyD_3; pfam13437 1155777004161 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155777004162 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155777004163 Walker A/P-loop; other site 1155777004164 ATP binding site [chemical binding]; other site 1155777004165 Q-loop/lid; other site 1155777004166 ABC transporter signature motif; other site 1155777004167 Walker B; other site 1155777004168 D-loop; other site 1155777004169 H-loop/switch region; other site 1155777004170 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155777004171 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155777004172 FtsX-like permease family; Region: FtsX; pfam02687 1155777004173 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155777004174 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1155777004175 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155777004176 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1155777004177 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155777004178 putative substrate binding site [chemical binding]; other site 1155777004179 putative ATP binding site [chemical binding]; other site 1155777004180 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1155777004181 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155777004182 active site 1155777004183 phosphorylation site [posttranslational modification] 1155777004184 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155777004185 active site 1155777004186 P-loop; other site 1155777004187 phosphorylation site [posttranslational modification] 1155777004188 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155777004189 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155777004190 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155777004191 Catalytic site [active] 1155777004192 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1155777004193 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777004194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777004195 ABC transporter; Region: ABC_tran_2; pfam12848 1155777004196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777004197 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1155777004198 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1155777004199 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1155777004200 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1155777004201 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1155777004202 rod-share determining protein MreBH; Provisional; Region: PRK13929 1155777004203 MreB and similar proteins; Region: MreB_like; cd10225 1155777004204 nucleotide binding site [chemical binding]; other site 1155777004205 Mg binding site [ion binding]; other site 1155777004206 putative protofilament interaction site [polypeptide binding]; other site 1155777004207 RodZ interaction site [polypeptide binding]; other site 1155777004208 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1155777004209 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1155777004210 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1155777004211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777004212 putative active site [active] 1155777004213 heme pocket [chemical binding]; other site 1155777004214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777004215 dimer interface [polypeptide binding]; other site 1155777004216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777004217 ATP binding site [chemical binding]; other site 1155777004218 Mg2+ binding site [ion binding]; other site 1155777004219 G-X-G motif; other site 1155777004220 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1155777004221 putative active site pocket [active] 1155777004222 dimerization interface [polypeptide binding]; other site 1155777004223 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1155777004224 putative active site pocket [active] 1155777004225 dimerization interface [polypeptide binding]; other site 1155777004226 putative catalytic residue [active] 1155777004227 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1155777004228 TrkA-N domain; Region: TrkA_N; pfam02254 1155777004229 TrkA-C domain; Region: TrkA_C; pfam02080 1155777004230 adenine deaminase; Region: ade; TIGR01178 1155777004231 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155777004232 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1155777004233 active site 1155777004234 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1155777004235 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1155777004236 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1155777004237 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1155777004238 hypothetical protein; Provisional; Region: PRK13667 1155777004239 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1155777004240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777004241 active site 1155777004242 motif I; other site 1155777004243 motif II; other site 1155777004244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777004245 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1155777004246 active site 1155777004247 catalytic residues [active] 1155777004248 metal binding site [ion binding]; metal-binding site 1155777004249 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1155777004250 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155777004251 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155777004252 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1155777004253 FMN binding site [chemical binding]; other site 1155777004254 substrate binding site [chemical binding]; other site 1155777004255 putative catalytic residue [active] 1155777004256 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004257 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004258 active site 1155777004259 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004260 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004261 putative NADP binding site [chemical binding]; other site 1155777004262 active site 1155777004263 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777004264 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004265 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004266 active site 1155777004267 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777004268 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004269 putative NADP binding site [chemical binding]; other site 1155777004270 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004271 active site 1155777004272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004273 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004274 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1155777004275 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004276 active site 1155777004277 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777004278 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004279 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004280 putative NADP binding site [chemical binding]; other site 1155777004281 active site 1155777004282 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004283 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004284 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004285 active site 1155777004286 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777004287 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004288 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004289 putative NADP binding site [chemical binding]; other site 1155777004290 active site 1155777004291 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777004292 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004293 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004294 active site 1155777004295 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777004296 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004297 putative NADP binding site [chemical binding]; other site 1155777004298 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004299 active site 1155777004300 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004301 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004302 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1155777004303 active site 1155777004304 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004305 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004306 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004307 putative NADP binding site [chemical binding]; other site 1155777004308 active site 1155777004309 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777004310 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004311 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004312 active site 1155777004313 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004314 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004315 putative NADP binding site [chemical binding]; other site 1155777004316 active site 1155777004317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004318 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004319 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004320 active site 1155777004321 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004322 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777004323 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004324 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004325 putative NADP binding site [chemical binding]; other site 1155777004326 active site 1155777004327 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004328 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004329 active site 1155777004330 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777004331 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004332 putative NADP binding site [chemical binding]; other site 1155777004333 KR domain; Region: KR; pfam08659 1155777004334 active site 1155777004335 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777004336 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004337 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004338 active site 1155777004339 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004340 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004341 putative NADP binding site [chemical binding]; other site 1155777004342 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777004343 active site 1155777004344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777004345 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777004346 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777004347 active site 1155777004348 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777004349 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777004350 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777004351 putative NADP binding site [chemical binding]; other site 1155777004352 KR domain; Region: KR; pfam08659 1155777004353 active site 1155777004354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155777004355 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155777004356 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155777004357 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1155777004358 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1155777004359 TPP-binding site [chemical binding]; other site 1155777004360 tetramer interface [polypeptide binding]; other site 1155777004361 heterodimer interface [polypeptide binding]; other site 1155777004362 phosphorylation loop region [posttranslational modification] 1155777004363 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1155777004364 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1155777004365 alpha subunit interface [polypeptide binding]; other site 1155777004366 TPP binding site [chemical binding]; other site 1155777004367 heterodimer interface [polypeptide binding]; other site 1155777004368 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155777004369 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1155777004370 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155777004371 E3 interaction surface; other site 1155777004372 lipoyl attachment site [posttranslational modification]; other site 1155777004373 e3 binding domain; Region: E3_binding; pfam02817 1155777004374 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155777004375 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1155777004376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155777004377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777004378 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155777004379 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1155777004380 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1155777004381 NodB motif; other site 1155777004382 active site 1155777004383 catalytic site [active] 1155777004384 metal binding site [ion binding]; metal-binding site 1155777004385 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1155777004386 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1155777004387 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1155777004388 homodimer interface [polypeptide binding]; other site 1155777004389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777004390 catalytic residue [active] 1155777004391 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1155777004392 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1155777004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1155777004394 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1155777004395 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1155777004396 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1155777004397 active site 1155777004398 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1155777004399 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155777004400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777004401 Coenzyme A binding pocket [chemical binding]; other site 1155777004402 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1155777004403 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1155777004404 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155777004405 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1155777004406 active site 1155777004407 Zn binding site [ion binding]; other site 1155777004408 Putative zinc-finger; Region: zf-HC2; pfam13490 1155777004409 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1155777004410 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1155777004411 G1 box; other site 1155777004412 putative GEF interaction site [polypeptide binding]; other site 1155777004413 GTP/Mg2+ binding site [chemical binding]; other site 1155777004414 Switch I region; other site 1155777004415 G2 box; other site 1155777004416 G3 box; other site 1155777004417 Switch II region; other site 1155777004418 G4 box; other site 1155777004419 G5 box; other site 1155777004420 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1155777004421 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1155777004422 YlaH-like protein; Region: YlaH; pfam14036 1155777004423 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1155777004424 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1155777004425 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1155777004426 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1155777004427 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1155777004428 putative active site [active] 1155777004429 PhoH-like protein; Region: PhoH; pfam02562 1155777004430 Glutaminase; Region: Glutaminase; cl00907 1155777004431 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1155777004432 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1155777004433 Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484 1155777004434 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1155777004435 nucleophilic elbow; other site 1155777004436 catalytic triad; other site 1155777004437 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155777004438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777004439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777004440 binding surface 1155777004441 TPR motif; other site 1155777004442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777004443 Short C-terminal domain; Region: SHOCT; pfam09851 1155777004444 Bacterial SH3 domain; Region: SH3_3; pfam08239 1155777004445 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1155777004446 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1155777004447 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1155777004448 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1155777004449 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155777004450 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155777004451 catalytic residue [active] 1155777004452 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155777004453 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155777004454 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 1155777004455 GIY-YIG motif/motif A; other site 1155777004456 putative active site [active] 1155777004457 catalytic site [active] 1155777004458 putative metal binding site [ion binding]; other site 1155777004459 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1155777004460 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1155777004461 Phage integrase family; Region: Phage_integrase; pfam00589 1155777004462 active site 1155777004463 DNA binding site [nucleotide binding] 1155777004464 Int/Topo IB signature motif; other site 1155777004465 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1155777004466 NUMOD4 motif; Region: NUMOD4; pfam07463 1155777004467 HNH endonuclease; Region: HNH_3; pfam13392 1155777004468 RNA dependent RNA polymerase; Region: RdRP; pfam05183 1155777004469 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1155777004470 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1155777004471 catalytic residues [active] 1155777004472 catalytic nucleophile [active] 1155777004473 Recombinase; Region: Recombinase; pfam07508 1155777004474 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1155777004475 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1155777004476 Glutaminase; Region: Glutaminase; cl00907 1155777004477 hypothetical protein; Provisional; Region: PRK13666 1155777004478 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1155777004479 pyruvate carboxylase; Reviewed; Region: PRK12999 1155777004480 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155777004481 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155777004482 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1155777004483 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1155777004484 active site 1155777004485 catalytic residues [active] 1155777004486 metal binding site [ion binding]; metal-binding site 1155777004487 homodimer binding site [polypeptide binding]; other site 1155777004488 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155777004489 carboxyltransferase (CT) interaction site; other site 1155777004490 biotinylation site [posttranslational modification]; other site 1155777004491 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1155777004492 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1155777004493 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1155777004494 UbiA prenyltransferase family; Region: UbiA; pfam01040 1155777004495 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1155777004496 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1155777004497 Cytochrome c; Region: Cytochrom_C; pfam00034 1155777004498 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1155777004499 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1155777004500 D-pathway; other site 1155777004501 Putative ubiquinol binding site [chemical binding]; other site 1155777004502 Low-spin heme (heme b) binding site [chemical binding]; other site 1155777004503 Putative water exit pathway; other site 1155777004504 Binuclear center (heme o3/CuB) [ion binding]; other site 1155777004505 K-pathway; other site 1155777004506 Putative proton exit pathway; other site 1155777004507 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1155777004508 Subunit I/III interface [polypeptide binding]; other site 1155777004509 Subunit III/IV interface [polypeptide binding]; other site 1155777004510 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1155777004511 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1155777004512 YugN-like family; Region: YugN; pfam08868 1155777004513 FOG: CBS domain [General function prediction only]; Region: COG0517 1155777004514 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1155777004515 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1155777004516 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1155777004517 Putative coat protein; Region: YlbD_coat; pfam14071 1155777004518 YlbE-like protein; Region: YlbE; pfam14003 1155777004519 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1155777004520 hypothetical protein; Provisional; Region: PRK02886 1155777004521 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1155777004522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777004523 S-adenosylmethionine binding site [chemical binding]; other site 1155777004524 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1155777004525 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1155777004526 active site 1155777004527 (T/H)XGH motif; other site 1155777004528 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1155777004529 Nucleoside recognition; Region: Gate; pfam07670 1155777004530 Nucleoside recognition; Region: Gate; pfam07670 1155777004531 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1155777004532 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1155777004533 active site 1155777004534 nucleophile elbow; other site 1155777004535 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1155777004536 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1155777004537 protein binding site [polypeptide binding]; other site 1155777004538 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1155777004539 hypothetical protein; Provisional; Region: PRK13670 1155777004540 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1155777004541 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1155777004542 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1155777004543 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1155777004544 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1155777004545 hypothetical protein; Provisional; Region: PRK13688 1155777004546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777004547 Coenzyme A binding pocket [chemical binding]; other site 1155777004548 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1155777004549 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1155777004550 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1155777004551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1155777004552 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1155777004553 mraZ protein; Region: TIGR00242 1155777004554 MraZ protein; Region: MraZ; pfam02381 1155777004555 MraZ protein; Region: MraZ; pfam02381 1155777004556 MraW methylase family; Region: Methyltransf_5; pfam01795 1155777004557 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1155777004558 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1155777004559 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155777004560 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155777004561 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155777004562 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1155777004563 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1155777004564 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1155777004565 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155777004566 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155777004567 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1155777004568 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1155777004569 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155777004570 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155777004571 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155777004572 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1155777004573 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1155777004574 Mg++ binding site [ion binding]; other site 1155777004575 putative catalytic motif [active] 1155777004576 putative substrate binding site [chemical binding]; other site 1155777004577 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1155777004578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155777004579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155777004580 stage V sporulation protein E; Region: spoVE; TIGR02615 1155777004581 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1155777004582 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1155777004583 active site 1155777004584 homodimer interface [polypeptide binding]; other site 1155777004585 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1155777004586 FAD binding domain; Region: FAD_binding_4; pfam01565 1155777004587 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1155777004588 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1155777004589 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1155777004590 Cell division protein FtsQ; Region: FtsQ; pfam03799 1155777004591 cell division protein FtsA; Region: ftsA; TIGR01174 1155777004592 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155777004593 nucleotide binding site [chemical binding]; other site 1155777004594 Cell division protein FtsA; Region: FtsA; pfam14450 1155777004595 cell division protein FtsZ; Validated; Region: PRK09330 1155777004596 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1155777004597 nucleotide binding site [chemical binding]; other site 1155777004598 SulA interaction site; other site 1155777004599 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1155777004600 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1155777004601 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1155777004602 active site 1155777004603 catalytic triad [active] 1155777004604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1155777004605 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1155777004606 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1155777004607 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1155777004608 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1155777004609 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1155777004610 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1155777004611 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777004612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777004613 DNA binding residues [nucleotide binding] 1155777004614 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1155777004615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777004616 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155777004617 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777004618 DNA binding residues [nucleotide binding] 1155777004619 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155777004620 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155777004621 Walker A/P-loop; other site 1155777004622 ATP binding site [chemical binding]; other site 1155777004623 Q-loop/lid; other site 1155777004624 ABC transporter signature motif; other site 1155777004625 Walker B; other site 1155777004626 D-loop; other site 1155777004627 H-loop/switch region; other site 1155777004628 acetylornithine deacetylase; Validated; Region: PRK08596 1155777004629 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1155777004630 metal binding site [ion binding]; metal-binding site 1155777004631 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1155777004632 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1155777004633 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1155777004634 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1155777004635 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155777004636 catalytic residue [active] 1155777004637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1155777004638 YGGT family; Region: YGGT; pfam02325 1155777004639 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1155777004640 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777004641 RNA binding surface [nucleotide binding]; other site 1155777004642 DivIVA protein; Region: DivIVA; pfam05103 1155777004643 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155777004644 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1155777004645 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1155777004646 HIGH motif; other site 1155777004647 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155777004648 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1155777004649 active site 1155777004650 KMSKS motif; other site 1155777004651 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1155777004652 tRNA binding surface [nucleotide binding]; other site 1155777004653 anticodon binding site; other site 1155777004654 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1155777004655 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1155777004656 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1155777004657 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777004658 RNA binding surface [nucleotide binding]; other site 1155777004659 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155777004660 active site 1155777004661 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1155777004662 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777004663 active site 1155777004664 uracil-xanthine permease; Region: ncs2; TIGR00801 1155777004665 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1155777004666 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155777004667 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155777004668 dihydroorotase; Validated; Region: pyrC; PRK09357 1155777004669 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155777004670 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1155777004671 active site 1155777004672 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1155777004673 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1155777004674 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1155777004675 catalytic site [active] 1155777004676 subunit interface [polypeptide binding]; other site 1155777004677 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1155777004678 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155777004679 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155777004680 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1155777004681 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155777004682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155777004683 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1155777004684 IMP binding site; other site 1155777004685 dimer interface [polypeptide binding]; other site 1155777004686 interdomain contacts; other site 1155777004687 partial ornithine binding site; other site 1155777004688 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1155777004689 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1155777004690 FAD binding pocket [chemical binding]; other site 1155777004691 FAD binding motif [chemical binding]; other site 1155777004692 phosphate binding motif [ion binding]; other site 1155777004693 beta-alpha-beta structure motif; other site 1155777004694 NAD binding pocket [chemical binding]; other site 1155777004695 Iron coordination center [ion binding]; other site 1155777004696 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1155777004697 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1155777004698 heterodimer interface [polypeptide binding]; other site 1155777004699 active site 1155777004700 FMN binding site [chemical binding]; other site 1155777004701 homodimer interface [polypeptide binding]; other site 1155777004702 substrate binding site [chemical binding]; other site 1155777004703 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1155777004704 active site 1155777004705 dimer interface [polypeptide binding]; other site 1155777004706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777004707 active site 1155777004708 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1155777004709 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1155777004710 Active Sites [active] 1155777004711 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1155777004712 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1155777004713 ATP-sulfurylase; Region: ATPS; cd00517 1155777004714 active site 1155777004715 HXXH motif; other site 1155777004716 flexible loop; other site 1155777004717 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1155777004718 AAA domain; Region: AAA_18; pfam13238 1155777004719 ligand-binding site [chemical binding]; other site 1155777004720 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1155777004721 diphthine synthase; Region: dph5; TIGR00522 1155777004722 active site 1155777004723 SAM binding site [chemical binding]; other site 1155777004724 homodimer interface [polypeptide binding]; other site 1155777004725 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1155777004726 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1155777004727 putative active site [active] 1155777004728 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1155777004729 putative active site [active] 1155777004730 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1155777004731 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1155777004732 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1155777004733 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1155777004734 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1155777004735 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1155777004736 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1155777004737 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155777004738 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1155777004739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777004740 motif II; other site 1155777004741 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1155777004742 TIGR00255 family protein; Region: TIGR00255 1155777004743 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1155777004744 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1155777004745 hypothetical protein; Provisional; Region: PRK04323 1155777004746 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1155777004747 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1155777004748 catalytic site [active] 1155777004749 G-X2-G-X-G-K; other site 1155777004750 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1155777004751 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1155777004752 Flavoprotein; Region: Flavoprotein; pfam02441 1155777004753 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1155777004754 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1155777004755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777004756 ATP binding site [chemical binding]; other site 1155777004757 putative Mg++ binding site [ion binding]; other site 1155777004758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777004759 nucleotide binding region [chemical binding]; other site 1155777004760 ATP-binding site [chemical binding]; other site 1155777004761 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1155777004762 active site 1155777004763 catalytic residues [active] 1155777004764 metal binding site [ion binding]; metal-binding site 1155777004765 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1155777004766 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1155777004767 putative active site [active] 1155777004768 substrate binding site [chemical binding]; other site 1155777004769 putative cosubstrate binding site; other site 1155777004770 catalytic site [active] 1155777004771 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1155777004772 substrate binding site [chemical binding]; other site 1155777004773 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1155777004774 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1155777004775 putative RNA binding site [nucleotide binding]; other site 1155777004776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777004777 S-adenosylmethionine binding site [chemical binding]; other site 1155777004778 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1155777004779 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777004780 FeS/SAM binding site; other site 1155777004781 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1155777004782 Protein phosphatase 2C; Region: PP2C; pfam00481 1155777004783 active site 1155777004784 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1155777004785 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1155777004786 active site 1155777004787 ATP binding site [chemical binding]; other site 1155777004788 substrate binding site [chemical binding]; other site 1155777004789 activation loop (A-loop); other site 1155777004790 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1155777004791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1155777004792 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155777004793 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155777004794 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155777004795 GTPase RsgA; Reviewed; Region: PRK00098 1155777004796 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1155777004797 RNA binding site [nucleotide binding]; other site 1155777004798 homodimer interface [polypeptide binding]; other site 1155777004799 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1155777004800 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1155777004801 GTP/Mg2+ binding site [chemical binding]; other site 1155777004802 G4 box; other site 1155777004803 G5 box; other site 1155777004804 G1 box; other site 1155777004805 Switch I region; other site 1155777004806 G2 box; other site 1155777004807 G3 box; other site 1155777004808 Switch II region; other site 1155777004809 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1155777004810 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1155777004811 substrate binding site [chemical binding]; other site 1155777004812 hexamer interface [polypeptide binding]; other site 1155777004813 metal binding site [ion binding]; metal-binding site 1155777004814 Thiamine pyrophosphokinase; Region: TPK; cd07995 1155777004815 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1155777004816 active site 1155777004817 dimerization interface [polypeptide binding]; other site 1155777004818 thiamine binding site [chemical binding]; other site 1155777004819 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1155777004820 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1155777004821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1155777004822 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1155777004823 DAK2 domain; Region: Dak2; pfam02734 1155777004824 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1155777004825 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1155777004826 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1155777004827 putative L-serine binding site [chemical binding]; other site 1155777004828 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1155777004829 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1155777004830 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1155777004831 Y-family of DNA polymerases; Region: PolY; cl12025 1155777004832 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1155777004833 generic binding surface II; other site 1155777004834 ssDNA binding site; other site 1155777004835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777004836 ATP binding site [chemical binding]; other site 1155777004837 putative Mg++ binding site [ion binding]; other site 1155777004838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777004839 nucleotide binding region [chemical binding]; other site 1155777004840 ATP-binding site [chemical binding]; other site 1155777004841 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1155777004842 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1155777004843 putative phosphate acyltransferase; Provisional; Region: PRK05331 1155777004844 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155777004845 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155777004846 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1155777004847 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1155777004848 NAD(P) binding site [chemical binding]; other site 1155777004849 homotetramer interface [polypeptide binding]; other site 1155777004850 homodimer interface [polypeptide binding]; other site 1155777004851 active site 1155777004852 acyl carrier protein; Provisional; Region: acpP; PRK00982 1155777004853 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1155777004854 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1155777004855 dimerization interface [polypeptide binding]; other site 1155777004856 active site 1155777004857 metal binding site [ion binding]; metal-binding site 1155777004858 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1155777004859 dsRNA binding site [nucleotide binding]; other site 1155777004860 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1155777004861 AAA domain; Region: AAA_23; pfam13476 1155777004862 Walker A/P-loop; other site 1155777004863 ATP binding site [chemical binding]; other site 1155777004864 Q-loop/lid; other site 1155777004865 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1155777004866 AAA domain; Region: AAA_21; pfam13304 1155777004867 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1155777004868 ABC transporter signature motif; other site 1155777004869 Walker B; other site 1155777004870 D-loop; other site 1155777004871 H-loop/switch region; other site 1155777004872 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1155777004873 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1155777004874 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1155777004875 GTP binding site [chemical binding]; other site 1155777004876 Phosphotransferase enzyme family; Region: APH; pfam01636 1155777004877 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1155777004878 active site 1155777004879 ATP binding site [chemical binding]; other site 1155777004880 putative DNA-binding protein; Validated; Region: PRK00118 1155777004881 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1155777004882 signal recognition particle protein; Provisional; Region: PRK10867 1155777004883 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1155777004884 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1155777004885 P loop; other site 1155777004886 GTP binding site [chemical binding]; other site 1155777004887 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1155777004888 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1155777004889 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1155777004890 KH domain; Region: KH_4; pfam13083 1155777004891 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1155777004892 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1155777004893 RimM N-terminal domain; Region: RimM; pfam01782 1155777004894 PRC-barrel domain; Region: PRC; pfam05239 1155777004895 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1155777004896 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1155777004897 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1155777004898 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1155777004899 GTP/Mg2+ binding site [chemical binding]; other site 1155777004900 G4 box; other site 1155777004901 G5 box; other site 1155777004902 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1155777004903 G1 box; other site 1155777004904 G1 box; other site 1155777004905 GTP/Mg2+ binding site [chemical binding]; other site 1155777004906 Switch I region; other site 1155777004907 G2 box; other site 1155777004908 G2 box; other site 1155777004909 G3 box; other site 1155777004910 G3 box; other site 1155777004911 Switch II region; other site 1155777004912 Switch II region; other site 1155777004913 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1155777004914 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155777004915 active site 1155777004916 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1155777004917 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1155777004918 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1155777004919 CoA-ligase; Region: Ligase_CoA; pfam00549 1155777004920 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1155777004921 CoA binding domain; Region: CoA_binding; smart00881 1155777004922 CoA-ligase; Region: Ligase_CoA; pfam00549 1155777004923 DNA protecting protein DprA; Region: dprA; TIGR00732 1155777004924 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1155777004925 DNA topoisomerase I; Validated; Region: PRK05582 1155777004926 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1155777004927 active site 1155777004928 interdomain interaction site; other site 1155777004929 putative metal-binding site [ion binding]; other site 1155777004930 nucleotide binding site [chemical binding]; other site 1155777004931 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155777004932 domain I; other site 1155777004933 DNA binding groove [nucleotide binding] 1155777004934 phosphate binding site [ion binding]; other site 1155777004935 domain II; other site 1155777004936 domain III; other site 1155777004937 nucleotide binding site [chemical binding]; other site 1155777004938 catalytic site [active] 1155777004939 domain IV; other site 1155777004940 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155777004941 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155777004942 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1155777004943 Glucose inhibited division protein A; Region: GIDA; pfam01134 1155777004944 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1155777004945 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1155777004946 active site 1155777004947 Int/Topo IB signature motif; other site 1155777004948 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1155777004949 active site 1155777004950 HslU subunit interaction site [polypeptide binding]; other site 1155777004951 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1155777004952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777004953 Walker A motif; other site 1155777004954 ATP binding site [chemical binding]; other site 1155777004955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1155777004956 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155777004957 transcriptional repressor CodY; Validated; Region: PRK04158 1155777004958 CodY GAF-like domain; Region: CodY; pfam06018 1155777004959 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1155777004960 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1155777004961 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1155777004962 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1155777004963 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1155777004964 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1155777004965 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1155777004966 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1155777004967 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1155777004968 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1155777004969 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1155777004970 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1155777004971 MgtE intracellular N domain; Region: MgtE_N; smart00924 1155777004972 FliG C-terminal domain; Region: FliG_C; pfam01706 1155777004973 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1155777004974 Flagellar assembly protein FliH; Region: FliH; pfam02108 1155777004975 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1155777004976 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155777004977 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1155777004978 Walker A motif/ATP binding site; other site 1155777004979 Walker B motif; other site 1155777004980 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1155777004981 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1155777004982 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1155777004983 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1155777004984 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1155777004985 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1155777004986 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1155777004987 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1155777004988 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1155777004989 Flagellar protein (FlbD); Region: FlbD; pfam06289 1155777004990 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1155777004991 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1155777004992 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1155777004993 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1155777004994 flagellar motor switch protein; Validated; Region: PRK08119 1155777004995 CheC-like family; Region: CheC; pfam04509 1155777004996 CheC-like family; Region: CheC; pfam04509 1155777004997 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1155777004998 Response regulator receiver domain; Region: Response_reg; pfam00072 1155777004999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777005000 active site 1155777005001 phosphorylation site [posttranslational modification] 1155777005002 intermolecular recognition site; other site 1155777005003 dimerization interface [polypeptide binding]; other site 1155777005004 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1155777005005 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1155777005006 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1155777005007 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1155777005008 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1155777005009 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1155777005010 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1155777005011 FHIPEP family; Region: FHIPEP; pfam00771 1155777005012 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1155777005013 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155777005014 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1155777005015 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1155777005016 P-loop; other site 1155777005017 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1155777005018 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1155777005019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777005020 active site 1155777005021 phosphorylation site [posttranslational modification] 1155777005022 intermolecular recognition site; other site 1155777005023 dimerization interface [polypeptide binding]; other site 1155777005024 CheB methylesterase; Region: CheB_methylest; pfam01339 1155777005025 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1155777005026 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1155777005027 putative binding surface; other site 1155777005028 active site 1155777005029 P2 response regulator binding domain; Region: P2; pfam07194 1155777005030 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1155777005031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777005032 ATP binding site [chemical binding]; other site 1155777005033 Mg2+ binding site [ion binding]; other site 1155777005034 G-X-G motif; other site 1155777005035 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1155777005036 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1155777005037 putative CheA interaction surface; other site 1155777005038 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1155777005039 CheC-like family; Region: CheC; pfam04509 1155777005040 CheC-like family; Region: CheC; pfam04509 1155777005041 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1155777005042 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1155777005043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777005044 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155777005045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777005046 DNA binding residues [nucleotide binding] 1155777005047 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1155777005048 rRNA interaction site [nucleotide binding]; other site 1155777005049 S8 interaction site; other site 1155777005050 putative laminin-1 binding site; other site 1155777005051 elongation factor Ts; Provisional; Region: tsf; PRK09377 1155777005052 UBA/TS-N domain; Region: UBA; pfam00627 1155777005053 Elongation factor TS; Region: EF_TS; pfam00889 1155777005054 Elongation factor TS; Region: EF_TS; pfam00889 1155777005055 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1155777005056 putative nucleotide binding site [chemical binding]; other site 1155777005057 uridine monophosphate binding site [chemical binding]; other site 1155777005058 homohexameric interface [polypeptide binding]; other site 1155777005059 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1155777005060 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1155777005061 hinge region; other site 1155777005062 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1155777005063 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1155777005064 catalytic residue [active] 1155777005065 putative FPP diphosphate binding site; other site 1155777005066 putative FPP binding hydrophobic cleft; other site 1155777005067 dimer interface [polypeptide binding]; other site 1155777005068 putative IPP diphosphate binding site; other site 1155777005069 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1155777005070 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1155777005071 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1155777005072 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1155777005073 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1155777005074 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1155777005075 RIP metalloprotease RseP; Region: TIGR00054 1155777005076 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1155777005077 active site 1155777005078 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1155777005079 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1155777005080 protein binding site [polypeptide binding]; other site 1155777005081 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1155777005082 putative substrate binding region [chemical binding]; other site 1155777005083 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1155777005084 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1155777005085 dimer interface [polypeptide binding]; other site 1155777005086 motif 1; other site 1155777005087 active site 1155777005088 motif 2; other site 1155777005089 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1155777005090 putative deacylase active site [active] 1155777005091 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1155777005092 active site 1155777005093 motif 3; other site 1155777005094 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1155777005095 anticodon binding site; other site 1155777005096 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1155777005097 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1155777005098 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1155777005099 generic binding surface II; other site 1155777005100 generic binding surface I; other site 1155777005101 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155777005102 active site 1155777005103 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1155777005104 active site 1155777005105 catalytic site [active] 1155777005106 substrate binding site [chemical binding]; other site 1155777005107 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1155777005108 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1155777005109 Sm and related proteins; Region: Sm_like; cl00259 1155777005110 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1155777005111 putative oligomer interface [polypeptide binding]; other site 1155777005112 putative RNA binding site [nucleotide binding]; other site 1155777005113 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1155777005114 NusA N-terminal domain; Region: NusA_N; pfam08529 1155777005115 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1155777005116 RNA binding site [nucleotide binding]; other site 1155777005117 homodimer interface [polypeptide binding]; other site 1155777005118 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1155777005119 G-X-X-G motif; other site 1155777005120 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1155777005121 G-X-X-G motif; other site 1155777005122 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1155777005123 putative RNA binding cleft [nucleotide binding]; other site 1155777005124 hypothetical protein; Provisional; Region: PRK07714 1155777005125 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1155777005126 translation initiation factor IF-2; Region: IF-2; TIGR00487 1155777005127 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1155777005128 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1155777005129 G1 box; other site 1155777005130 putative GEF interaction site [polypeptide binding]; other site 1155777005131 GTP/Mg2+ binding site [chemical binding]; other site 1155777005132 Switch I region; other site 1155777005133 G2 box; other site 1155777005134 G3 box; other site 1155777005135 Switch II region; other site 1155777005136 G4 box; other site 1155777005137 G5 box; other site 1155777005138 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1155777005139 Translation-initiation factor 2; Region: IF-2; pfam11987 1155777005140 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1155777005141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1155777005142 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1155777005143 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1155777005144 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1155777005145 RNA binding site [nucleotide binding]; other site 1155777005146 active site 1155777005147 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1155777005148 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1155777005149 active site 1155777005150 Riboflavin kinase; Region: Flavokinase; smart00904 1155777005151 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1155777005152 16S/18S rRNA binding site [nucleotide binding]; other site 1155777005153 S13e-L30e interaction site [polypeptide binding]; other site 1155777005154 25S rRNA binding site [nucleotide binding]; other site 1155777005155 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1155777005156 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1155777005157 RNase E interface [polypeptide binding]; other site 1155777005158 trimer interface [polypeptide binding]; other site 1155777005159 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1155777005160 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1155777005161 RNase E interface [polypeptide binding]; other site 1155777005162 trimer interface [polypeptide binding]; other site 1155777005163 active site 1155777005164 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1155777005165 putative nucleic acid binding region [nucleotide binding]; other site 1155777005166 G-X-X-G motif; other site 1155777005167 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1155777005168 RNA binding site [nucleotide binding]; other site 1155777005169 domain interface; other site 1155777005170 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1155777005171 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1155777005172 NodB motif; other site 1155777005173 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155777005174 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1155777005175 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155777005176 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1155777005177 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1155777005178 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1155777005179 NAD binding site [chemical binding]; other site 1155777005180 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1155777005181 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1155777005182 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1155777005183 aspartate kinase I; Reviewed; Region: PRK08210 1155777005184 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1155777005185 putative catalytic residues [active] 1155777005186 putative nucleotide binding site [chemical binding]; other site 1155777005187 putative aspartate binding site [chemical binding]; other site 1155777005188 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1155777005189 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1155777005190 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1155777005191 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1155777005192 dimer interface [polypeptide binding]; other site 1155777005193 active site 1155777005194 catalytic residue [active] 1155777005195 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1155777005196 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155777005197 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1155777005198 Clp protease; Region: CLP_protease; pfam00574 1155777005199 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1155777005200 active site 1155777005201 YlzJ-like protein; Region: YlzJ; pfam14035 1155777005202 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1155777005203 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1155777005204 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155777005205 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1155777005206 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155777005207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777005208 DNA-binding site [nucleotide binding]; DNA binding site 1155777005209 UTRA domain; Region: UTRA; pfam07702 1155777005210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777005211 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777005212 putative substrate translocation pore; other site 1155777005213 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777005214 MarR family; Region: MarR_2; pfam12802 1155777005215 MMPL family; Region: MMPL; pfam03176 1155777005216 Predicted membrane protein [Function unknown]; Region: COG1511 1155777005217 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1155777005218 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155777005219 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155777005220 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155777005221 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1155777005222 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155777005223 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1155777005224 classical (c) SDRs; Region: SDR_c; cd05233 1155777005225 NAD(P) binding site [chemical binding]; other site 1155777005226 active site 1155777005227 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1155777005228 ACT domain; Region: ACT; pfam01842 1155777005229 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1155777005230 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1155777005231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777005232 non-specific DNA binding site [nucleotide binding]; other site 1155777005233 salt bridge; other site 1155777005234 sequence-specific DNA binding site [nucleotide binding]; other site 1155777005235 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1155777005236 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1155777005237 competence damage-inducible protein A; Provisional; Region: PRK00549 1155777005238 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1155777005239 putative MPT binding site; other site 1155777005240 Competence-damaged protein; Region: CinA; pfam02464 1155777005241 recombinase A; Provisional; Region: recA; PRK09354 1155777005242 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1155777005243 hexamer interface [polypeptide binding]; other site 1155777005244 Walker A motif; other site 1155777005245 ATP binding site [chemical binding]; other site 1155777005246 Walker B motif; other site 1155777005247 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155777005248 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155777005249 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1155777005250 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1155777005251 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155777005252 Zn2+ binding site [ion binding]; other site 1155777005253 Mg2+ binding site [ion binding]; other site 1155777005254 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1155777005255 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155777005256 putative active site [active] 1155777005257 metal binding site [ion binding]; metal-binding site 1155777005258 homodimer binding site [polypeptide binding]; other site 1155777005259 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1155777005260 Threonine dehydrogenase; Region: TDH; cd05281 1155777005261 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1155777005262 structural Zn binding site [ion binding]; other site 1155777005263 catalytic Zn binding site [ion binding]; other site 1155777005264 tetramer interface [polypeptide binding]; other site 1155777005265 NADP binding site [chemical binding]; other site 1155777005266 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1155777005267 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1155777005268 substrate-cofactor binding pocket; other site 1155777005269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777005270 catalytic residue [active] 1155777005271 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1155777005272 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1155777005273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777005274 FeS/SAM binding site; other site 1155777005275 TRAM domain; Region: TRAM; pfam01938 1155777005276 Predicted membrane protein [Function unknown]; Region: COG4550 1155777005277 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1155777005278 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1155777005279 MutS domain I; Region: MutS_I; pfam01624 1155777005280 MutS domain II; Region: MutS_II; pfam05188 1155777005281 MutS domain III; Region: MutS_III; pfam05192 1155777005282 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1155777005283 Walker A/P-loop; other site 1155777005284 ATP binding site [chemical binding]; other site 1155777005285 Q-loop/lid; other site 1155777005286 ABC transporter signature motif; other site 1155777005287 Walker B; other site 1155777005288 D-loop; other site 1155777005289 H-loop/switch region; other site 1155777005290 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1155777005291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777005292 ATP binding site [chemical binding]; other site 1155777005293 Mg2+ binding site [ion binding]; other site 1155777005294 G-X-G motif; other site 1155777005295 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1155777005296 ATP binding site [chemical binding]; other site 1155777005297 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1155777005298 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155777005299 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155777005300 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1155777005301 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155777005302 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155777005303 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155777005304 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1155777005305 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155777005306 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155777005307 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1155777005308 FMN binding site [chemical binding]; other site 1155777005309 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1155777005310 substrate binding site [chemical binding]; other site 1155777005311 putative catalytic residue [active] 1155777005312 acyl carrier protein; Validated; Region: PRK07117 1155777005313 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1155777005314 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1155777005315 dimer interface [polypeptide binding]; other site 1155777005316 active site 1155777005317 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155777005318 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1155777005319 substrate binding site [chemical binding]; other site 1155777005320 oxyanion hole (OAH) forming residues; other site 1155777005321 trimer interface [polypeptide binding]; other site 1155777005322 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1155777005323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155777005324 substrate binding site [chemical binding]; other site 1155777005325 oxyanion hole (OAH) forming residues; other site 1155777005326 trimer interface [polypeptide binding]; other site 1155777005327 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1155777005328 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1155777005329 acyl-activating enzyme (AAE) consensus motif; other site 1155777005330 putative AMP binding site [chemical binding]; other site 1155777005331 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005332 Condensation domain; Region: Condensation; pfam00668 1155777005333 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005334 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005335 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1155777005336 acyl-activating enzyme (AAE) consensus motif; other site 1155777005337 AMP binding site [chemical binding]; other site 1155777005338 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005339 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777005340 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005341 active site 1155777005342 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777005343 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005344 KR domain; Region: KR; pfam08659 1155777005345 putative NADP binding site [chemical binding]; other site 1155777005346 active site 1155777005347 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005348 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777005349 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005350 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777005351 active site 1155777005352 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005353 putative NADP binding site [chemical binding]; other site 1155777005354 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777005355 active site 1155777005356 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005357 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005358 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777005359 active site 1155777005360 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777005361 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777005362 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005363 active site 1155777005364 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777005365 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005366 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777005367 putative NADP binding site [chemical binding]; other site 1155777005368 active site 1155777005369 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777005370 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005371 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777005372 active site 1155777005373 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777005374 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777005375 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005376 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777005377 active site 1155777005378 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005379 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777005380 putative NADP binding site [chemical binding]; other site 1155777005381 active site 1155777005382 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005383 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005384 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777005385 active site 1155777005386 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777005387 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005388 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005389 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777005390 active site 1155777005391 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777005392 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005393 putative NADP binding site [chemical binding]; other site 1155777005394 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777005395 active site 1155777005396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777005397 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005398 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005399 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777005400 active site 1155777005401 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005402 putative NADP binding site [chemical binding]; other site 1155777005403 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777005404 active site 1155777005405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005406 Condensation domain; Region: Condensation; pfam00668 1155777005407 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005408 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005409 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777005410 acyl-activating enzyme (AAE) consensus motif; other site 1155777005411 AMP binding site [chemical binding]; other site 1155777005412 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005413 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777005414 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005415 active site 1155777005416 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777005417 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005418 putative NADP binding site [chemical binding]; other site 1155777005419 KR domain; Region: KR; pfam08659 1155777005420 active site 1155777005421 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777005422 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777005423 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005424 active site 1155777005425 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777005426 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005427 putative NADP binding site [chemical binding]; other site 1155777005428 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777005429 active site 1155777005430 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777005431 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777005432 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005433 active site 1155777005434 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777005435 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777005436 putative NADP binding site [chemical binding]; other site 1155777005437 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777005438 active site 1155777005439 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1155777005440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777005441 S-adenosylmethionine binding site [chemical binding]; other site 1155777005442 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777005443 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005444 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777005445 active site 1155777005446 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777005447 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1155777005448 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005449 active site 1155777005450 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005451 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1155777005452 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1155777005453 Cytochrome P450; Region: p450; cl12078 1155777005454 similar to nuclease NucB, partial 1155777005455 similar to Sporulation-specific extracellular nuclease NucB, partial 1155777005456 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1155777005457 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1155777005458 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1155777005459 active site 1155777005460 catalytic triad [active] 1155777005461 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1155777005462 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1155777005463 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1155777005464 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1155777005465 YmaF family; Region: YmaF; pfam12788 1155777005466 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1155777005467 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1155777005468 bacterial Hfq-like; Region: Hfq; cd01716 1155777005469 hexamer interface [polypeptide binding]; other site 1155777005470 Sm1 motif; other site 1155777005471 RNA binding site [nucleotide binding]; other site 1155777005472 Sm2 motif; other site 1155777005473 YmzC-like protein; Region: YmzC; pfam14157 1155777005474 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1155777005475 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1155777005476 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1155777005477 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1155777005478 active site 1155777005479 dimer interface [polypeptide binding]; other site 1155777005480 catalytic residues [active] 1155777005481 effector binding site; other site 1155777005482 R2 peptide binding site; other site 1155777005483 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1155777005484 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1155777005485 dimer interface [polypeptide binding]; other site 1155777005486 putative radical transfer pathway; other site 1155777005487 diiron center [ion binding]; other site 1155777005488 tyrosyl radical; other site 1155777005489 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1155777005490 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1155777005491 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1155777005492 active site 1155777005493 metal binding site [ion binding]; metal-binding site 1155777005494 Sporulation related domain; Region: SPOR; cl10051 1155777005495 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1155777005496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777005497 Walker A motif; other site 1155777005498 ATP binding site [chemical binding]; other site 1155777005499 Walker B motif; other site 1155777005500 arginine finger; other site 1155777005501 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1155777005502 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1155777005503 HflX GTPase family; Region: HflX; cd01878 1155777005504 G1 box; other site 1155777005505 GTP/Mg2+ binding site [chemical binding]; other site 1155777005506 Switch I region; other site 1155777005507 G2 box; other site 1155777005508 G3 box; other site 1155777005509 Switch II region; other site 1155777005510 G4 box; other site 1155777005511 G5 box; other site 1155777005512 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1155777005513 Aluminium resistance protein; Region: Alum_res; pfam06838 1155777005514 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1155777005515 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155777005516 DNA binding residues [nucleotide binding] 1155777005517 glutamine synthetase, type I; Region: GlnA; TIGR00653 1155777005518 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1155777005519 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1155777005520 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155777005521 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155777005522 Int/Topo IB signature motif; other site 1155777005523 Staphylococcal nuclease homologues; Region: SNc; smart00318 1155777005524 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1155777005525 Catalytic site; other site 1155777005526 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1155777005527 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1155777005528 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1155777005529 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155777005530 sporulation protein YunB; Region: spo_yunB; TIGR02832 1155777005531 YolD-like protein; Region: YolD; pfam08863 1155777005532 DNA polymerase IV; Reviewed; Region: PRK03103 1155777005533 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1155777005534 active site 1155777005535 DNA binding site [nucleotide binding] 1155777005536 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1155777005537 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777005538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777005539 TPR motif; other site 1155777005540 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777005541 binding surface 1155777005542 Bacteriophage holin; Region: Phage_holin_1; pfam04531 1155777005543 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1155777005544 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155777005545 amidase catalytic site [active] 1155777005546 Zn binding residues [ion binding]; other site 1155777005547 substrate binding site [chemical binding]; other site 1155777005548 Bacterial SH3 domain; Region: SH3_3; pfam08239 1155777005549 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1155777005550 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1155777005551 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1155777005552 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1155777005553 Phage-related protein [Function unknown]; Region: COG4722 1155777005554 Phage tail protein; Region: Sipho_tail; cl17486 1155777005555 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1155777005556 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1155777005557 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1155777005558 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155777005559 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155777005560 catalytic residue [active] 1155777005561 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155777005562 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155777005563 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1155777005564 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1155777005565 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1155777005566 active site 1155777005567 catalytic residues [active] 1155777005568 DNA binding site [nucleotide binding] 1155777005569 Int/Topo IB signature motif; other site 1155777005570 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1155777005571 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1155777005572 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1155777005573 YonK protein; Region: YonK; pfam09642 1155777005574 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1155777005575 IHF dimer interface [polypeptide binding]; other site 1155777005576 IHF - DNA interface [nucleotide binding]; other site 1155777005577 RNA dependent RNA polymerase; Region: RdRP; pfam05183 1155777005578 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1155777005579 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 1155777005580 nucleotide binding site [chemical binding]; other site 1155777005581 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 1155777005582 GIY-YIG motif/motif A; other site 1155777005583 putative active site [active] 1155777005584 catalytic site [active] 1155777005585 putative metal binding site [ion binding]; other site 1155777005586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777005587 S-adenosylmethionine binding site [chemical binding]; other site 1155777005588 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1155777005589 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1155777005590 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1155777005591 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1155777005592 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1155777005593 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155777005594 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1155777005595 active site 1155777005596 catalytic residues [active] 1155777005597 DNA binding site [nucleotide binding] 1155777005598 Int/Topo IB signature motif; other site 1155777005599 DNA-sulfur modification-associated; Region: DndB; cl17621 1155777005600 DGQHR domain; Region: DGQHR; TIGR03187 1155777005601 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1155777005602 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1155777005603 active site 1155777005604 DNA binding site [nucleotide binding] 1155777005605 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1155777005606 YopX protein; Region: YopX; pfam09643 1155777005607 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1155777005608 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1155777005609 Right handed beta helix region; Region: Beta_helix; pfam13229 1155777005610 Right handed beta helix region; Region: Beta_helix; pfam13229 1155777005611 AAA domain; Region: AAA_24; pfam13479 1155777005612 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 1155777005613 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1155777005614 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1155777005615 ATP binding site [chemical binding]; other site 1155777005616 Walker B motif; other site 1155777005617 hypothetical protein; Provisional; Region: PRK08624 1155777005618 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1155777005619 active site 1155777005620 metal binding site [ion binding]; metal-binding site 1155777005621 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1155777005622 DHH family; Region: DHH; pfam01368 1155777005623 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1155777005624 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155777005625 active site 1155777005626 3D domain; Region: 3D; cl01439 1155777005627 YorP protein; Region: YorP; pfam09629 1155777005628 ribulose-bisphosphate carboxylase small chain; Region: PLN02289 1155777005629 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1155777005630 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1155777005631 active site 1155777005632 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1155777005633 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1155777005634 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1155777005635 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1155777005636 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1155777005637 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1155777005638 active site 1155777005639 dimer interface [polypeptide binding]; other site 1155777005640 catalytic residues [active] 1155777005641 effector binding site; other site 1155777005642 R2 peptide binding site; other site 1155777005643 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1155777005644 dimer interface [polypeptide binding]; other site 1155777005645 putative radical transfer pathway; other site 1155777005646 diiron center [ion binding]; other site 1155777005647 tyrosyl radical; other site 1155777005648 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1155777005649 catalytic residues [active] 1155777005650 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; pfam01981 1155777005651 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1155777005652 dimer interface [polypeptide binding]; other site 1155777005653 putative active site [active] 1155777005654 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1155777005655 trimer interface [polypeptide binding]; other site 1155777005656 active site 1155777005657 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1155777005658 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1155777005659 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1155777005660 dimerization interface [polypeptide binding]; other site 1155777005661 active site 1155777005662 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155777005663 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1155777005664 folate binding site [chemical binding]; other site 1155777005665 NADP+ binding site [chemical binding]; other site 1155777005666 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1155777005667 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1155777005668 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155777005669 active site 1155777005670 metal binding site [ion binding]; metal-binding site 1155777005671 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1155777005672 Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331 1155777005673 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1155777005674 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1155777005675 Major royal jelly protein; Region: MRJP; pfam03022 1155777005676 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1155777005677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777005678 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1155777005679 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1155777005680 inhibitor binding site; inhibition site 1155777005681 active site 1155777005682 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155777005683 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1155777005684 non-specific DNA interactions [nucleotide binding]; other site 1155777005685 DNA binding site [nucleotide binding] 1155777005686 sequence specific DNA binding site [nucleotide binding]; other site 1155777005687 putative cAMP binding site [chemical binding]; other site 1155777005688 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1155777005689 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155777005690 nucleotide binding site [chemical binding]; other site 1155777005691 xylose isomerase; Provisional; Region: PRK05474 1155777005692 xylose isomerase; Region: xylose_isom_A; TIGR02630 1155777005693 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1155777005694 N- and C-terminal domain interface [polypeptide binding]; other site 1155777005695 D-xylulose kinase; Region: XylB; TIGR01312 1155777005696 active site 1155777005697 MgATP binding site [chemical binding]; other site 1155777005698 catalytic site [active] 1155777005699 metal binding site [ion binding]; metal-binding site 1155777005700 xylulose binding site [chemical binding]; other site 1155777005701 homodimer interface [polypeptide binding]; other site 1155777005702 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1155777005703 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1155777005704 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1155777005705 Predicted transcriptional regulator [Transcription]; Region: COG2378 1155777005706 HTH domain; Region: HTH_11; pfam08279 1155777005707 WYL domain; Region: WYL; pfam13280 1155777005708 DinB family; Region: DinB; cl17821 1155777005709 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1155777005710 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1155777005711 NAD binding site [chemical binding]; other site 1155777005712 substrate binding site [chemical binding]; other site 1155777005713 catalytic Zn binding site [ion binding]; other site 1155777005714 tetramer interface [polypeptide binding]; other site 1155777005715 structural Zn binding site [ion binding]; other site 1155777005716 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155777005717 Coenzyme A binding pocket [chemical binding]; other site 1155777005718 YoaP-like; Region: YoaP; pfam14268 1155777005719 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1155777005720 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1155777005721 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1155777005722 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1155777005723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777005724 Coenzyme A binding pocket [chemical binding]; other site 1155777005725 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 1155777005726 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1155777005727 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1155777005728 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1155777005729 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1155777005730 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1155777005731 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155777005732 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155777005733 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1155777005734 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1155777005735 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1155777005736 trimer interface [polypeptide binding]; other site 1155777005737 active site 1155777005738 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1155777005739 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1155777005740 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1155777005741 LexA repressor; Validated; Region: PRK00215 1155777005742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777005743 putative DNA binding site [nucleotide binding]; other site 1155777005744 putative Zn2+ binding site [ion binding]; other site 1155777005745 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1155777005746 Catalytic site [active] 1155777005747 cell division suppressor protein YneA; Provisional; Region: PRK14125 1155777005748 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777005749 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1155777005750 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1155777005751 catalytic residues [active] 1155777005752 catalytic nucleophile [active] 1155777005753 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1155777005754 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1155777005755 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1155777005756 TPP-binding site [chemical binding]; other site 1155777005757 dimer interface [polypeptide binding]; other site 1155777005758 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1155777005759 PYR/PP interface [polypeptide binding]; other site 1155777005760 dimer interface [polypeptide binding]; other site 1155777005761 TPP binding site [chemical binding]; other site 1155777005762 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155777005763 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1155777005764 hypothetical protein; Provisional; Region: PRK01844 1155777005765 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1155777005766 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1155777005767 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1155777005768 Response regulator receiver domain; Region: Response_reg; pfam00072 1155777005769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777005770 active site 1155777005771 phosphorylation site [posttranslational modification] 1155777005772 intermolecular recognition site; other site 1155777005773 dimerization interface [polypeptide binding]; other site 1155777005774 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1155777005775 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1155777005776 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1155777005777 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1155777005778 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1155777005779 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1155777005780 aconitate hydratase; Validated; Region: PRK09277 1155777005781 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1155777005782 substrate binding site [chemical binding]; other site 1155777005783 ligand binding site [chemical binding]; other site 1155777005784 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1155777005785 substrate binding site [chemical binding]; other site 1155777005786 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1155777005787 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155777005788 catalytic residues [active] 1155777005789 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1155777005790 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1155777005791 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1155777005792 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155777005793 active site 1155777005794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1155777005795 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1155777005796 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1155777005797 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1155777005798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777005799 ATP binding site [chemical binding]; other site 1155777005800 Mg2+ binding site [ion binding]; other site 1155777005801 G-X-G motif; other site 1155777005802 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1155777005803 anchoring element; other site 1155777005804 dimer interface [polypeptide binding]; other site 1155777005805 ATP binding site [chemical binding]; other site 1155777005806 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1155777005807 active site 1155777005808 metal binding site [ion binding]; metal-binding site 1155777005809 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1155777005810 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1155777005811 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1155777005812 CAP-like domain; other site 1155777005813 active site 1155777005814 primary dimer interface [polypeptide binding]; other site 1155777005815 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777005816 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777005817 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777005818 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155777005819 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1155777005820 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1155777005821 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155777005822 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1155777005823 substrate binding site [chemical binding]; other site 1155777005824 ATP binding site [chemical binding]; other site 1155777005825 putative oxidoreductase; Provisional; Region: PRK10083 1155777005826 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1155777005827 putative NAD(P) binding site [chemical binding]; other site 1155777005828 catalytic Zn binding site [ion binding]; other site 1155777005829 structural Zn binding site [ion binding]; other site 1155777005830 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1155777005831 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1155777005832 active site 1155777005833 intersubunit interface [polypeptide binding]; other site 1155777005834 catalytic residue [active] 1155777005835 mannonate dehydratase; Provisional; Region: PRK03906 1155777005836 mannonate dehydratase; Region: uxuA; TIGR00695 1155777005837 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1155777005838 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1155777005839 putative NAD(P) binding site [chemical binding]; other site 1155777005840 active site 1155777005841 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777005842 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777005843 DNA binding site [nucleotide binding] 1155777005844 domain linker motif; other site 1155777005845 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1155777005846 putative dimerization interface [polypeptide binding]; other site 1155777005847 putative ligand binding site [chemical binding]; other site 1155777005848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777005849 D-galactonate transporter; Region: 2A0114; TIGR00893 1155777005850 putative substrate translocation pore; other site 1155777005851 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1155777005852 YndJ-like protein; Region: YndJ; pfam14158 1155777005853 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 1155777005854 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1155777005855 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1155777005856 Cellulose binding domain; Region: CBM_3; pfam00942 1155777005857 Tic20-like protein; Region: Tic20; pfam09685 1155777005858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777005859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1155777005860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777005861 dimer interface [polypeptide binding]; other site 1155777005862 phosphorylation site [posttranslational modification] 1155777005863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777005864 ATP binding site [chemical binding]; other site 1155777005865 Mg2+ binding site [ion binding]; other site 1155777005866 G-X-G motif; other site 1155777005867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777005868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777005869 active site 1155777005870 phosphorylation site [posttranslational modification] 1155777005871 intermolecular recognition site; other site 1155777005872 dimerization interface [polypeptide binding]; other site 1155777005873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777005874 DNA binding site [nucleotide binding] 1155777005875 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1155777005876 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1155777005877 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1155777005878 substrate binding site [chemical binding]; other site 1155777005879 active site 1155777005880 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1155777005881 metal binding site [ion binding]; metal-binding site 1155777005882 ligand binding site [chemical binding]; other site 1155777005883 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777005884 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1155777005885 acyl-activating enzyme (AAE) consensus motif; other site 1155777005886 AMP binding site [chemical binding]; other site 1155777005887 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005888 Condensation domain; Region: Condensation; pfam00668 1155777005889 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005890 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777005891 Condensation domain; Region: Condensation; pfam00668 1155777005892 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005893 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005894 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777005895 acyl-activating enzyme (AAE) consensus motif; other site 1155777005896 AMP binding site [chemical binding]; other site 1155777005897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005898 Thioesterase domain; Region: Thioesterase; pfam00975 1155777005899 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005900 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005901 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777005902 acyl-activating enzyme (AAE) consensus motif; other site 1155777005903 AMP binding site [chemical binding]; other site 1155777005904 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005905 Condensation domain; Region: Condensation; pfam00668 1155777005906 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005907 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777005908 Condensation domain; Region: Condensation; pfam00668 1155777005909 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005910 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777005911 acyl-activating enzyme (AAE) consensus motif; other site 1155777005912 AMP binding site [chemical binding]; other site 1155777005913 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005914 Condensation domain; Region: Condensation; pfam00668 1155777005915 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005916 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777005917 Condensation domain; Region: Condensation; pfam00668 1155777005918 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005919 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777005920 acyl-activating enzyme (AAE) consensus motif; other site 1155777005921 AMP binding site [chemical binding]; other site 1155777005922 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005923 Condensation domain; Region: Condensation; pfam00668 1155777005924 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005925 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005926 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777005927 acyl-activating enzyme (AAE) consensus motif; other site 1155777005928 AMP binding site [chemical binding]; other site 1155777005929 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005930 Condensation domain; Region: Condensation; pfam00668 1155777005931 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005932 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005933 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1155777005934 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1155777005935 acyl-activating enzyme (AAE) consensus motif; other site 1155777005936 putative AMP binding site [chemical binding]; other site 1155777005937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005938 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777005939 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777005940 active site 1155777005941 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005942 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1155777005943 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777005944 inhibitor-cofactor binding pocket; inhibition site 1155777005945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777005946 catalytic residue [active] 1155777005947 Condensation domain; Region: Condensation; pfam00668 1155777005948 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005949 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005950 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005951 Condensation domain; Region: Condensation; pfam00668 1155777005952 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005953 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005954 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777005955 acyl-activating enzyme (AAE) consensus motif; other site 1155777005956 AMP binding site [chemical binding]; other site 1155777005957 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777005958 Condensation domain; Region: Condensation; pfam00668 1155777005959 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777005960 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777005961 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155777005962 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155777005963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155777005964 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1155777005965 NAD(P) binding site [chemical binding]; other site 1155777005966 active site 1155777005967 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1155777005968 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1155777005969 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1155777005970 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1155777005971 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1155777005972 Cytochrome P450; Region: p450; cl12078 1155777005973 biotin synthase; Validated; Region: PRK06256 1155777005974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777005975 FeS/SAM binding site; other site 1155777005976 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1155777005977 AAA domain; Region: AAA_26; pfam13500 1155777005978 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155777005979 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1155777005980 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1155777005981 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1155777005982 substrate-cofactor binding pocket; other site 1155777005983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777005984 catalytic residue [active] 1155777005985 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1155777005986 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777005987 inhibitor-cofactor binding pocket; inhibition site 1155777005988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777005989 catalytic residue [active] 1155777005990 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1155777005991 Predicted membrane protein [Function unknown]; Region: COG2246 1155777005992 GtrA-like protein; Region: GtrA; pfam04138 1155777005993 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1155777005994 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1155777005995 active site 1155777005996 tetramer interface; other site 1155777005997 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1155777005998 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155777005999 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1155777006000 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1155777006001 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1155777006002 enoyl-CoA hydratase; Provisional; Region: PRK07657 1155777006003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155777006004 substrate binding site [chemical binding]; other site 1155777006005 oxyanion hole (OAH) forming residues; other site 1155777006006 trimer interface [polypeptide binding]; other site 1155777006007 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1155777006008 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1155777006009 active site 1155777006010 catalytic residues [active] 1155777006011 metal binding site [ion binding]; metal-binding site 1155777006012 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155777006013 carboxyltransferase (CT) interaction site; other site 1155777006014 biotinylation site [posttranslational modification]; other site 1155777006015 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1155777006016 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155777006017 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155777006018 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1155777006019 AMP-binding domain protein; Validated; Region: PRK08315 1155777006020 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1155777006021 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1155777006022 acyl-activating enzyme (AAE) consensus motif; other site 1155777006023 putative AMP binding site [chemical binding]; other site 1155777006024 putative active site [active] 1155777006025 putative CoA binding site [chemical binding]; other site 1155777006026 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1155777006027 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1155777006028 FAD binding site [chemical binding]; other site 1155777006029 homotetramer interface [polypeptide binding]; other site 1155777006030 substrate binding pocket [chemical binding]; other site 1155777006031 catalytic base [active] 1155777006032 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1155777006033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1155777006034 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1155777006035 Condensation domain; Region: Condensation; pfam00668 1155777006036 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777006037 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1155777006038 acyl-activating enzyme (AAE) consensus motif; other site 1155777006039 AMP binding site [chemical binding]; other site 1155777006040 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777006041 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1155777006042 Condensation domain; Region: Condensation; pfam00668 1155777006043 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777006044 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777006045 acyl-activating enzyme (AAE) consensus motif; other site 1155777006046 AMP binding site [chemical binding]; other site 1155777006047 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777006048 Condensation domain; Region: Condensation; pfam00668 1155777006049 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777006050 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777006051 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777006052 acyl-activating enzyme (AAE) consensus motif; other site 1155777006053 AMP binding site [chemical binding]; other site 1155777006054 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777006055 Condensation domain; Region: Condensation; pfam00668 1155777006056 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777006057 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777006058 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777006059 acyl-activating enzyme (AAE) consensus motif; other site 1155777006060 AMP binding site [chemical binding]; other site 1155777006061 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777006062 Condensation domain; Region: Condensation; pfam00668 1155777006063 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777006064 Condensation domain; Region: Condensation; pfam00668 1155777006065 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777006066 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777006067 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1155777006068 acyl-activating enzyme (AAE) consensus motif; other site 1155777006069 AMP binding site [chemical binding]; other site 1155777006070 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777006071 Condensation domain; Region: Condensation; pfam00668 1155777006072 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777006073 similar to fengycin synthetase B, partial 1155777006074 similar to fengycin synthetase B, partial 1155777006075 Condensation domain; Region: Condensation; pfam00668 1155777006076 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777006077 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777006078 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777006079 acyl-activating enzyme (AAE) consensus motif; other site 1155777006080 AMP binding site [chemical binding]; other site 1155777006081 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777006082 Condensation domain; Region: Condensation; pfam00668 1155777006083 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777006084 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777006085 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777006086 acyl-activating enzyme (AAE) consensus motif; other site 1155777006087 AMP binding site [chemical binding]; other site 1155777006088 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777006089 Condensation domain; Region: Condensation; pfam00668 1155777006090 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777006091 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777006092 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1155777006093 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1155777006094 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1155777006095 active site 1155777006096 catalytic residues [active] 1155777006097 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1155777006098 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1155777006099 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1155777006100 Int/Topo IB signature motif; other site 1155777006101 Helix-turn-helix domain; Region: HTH_17; cl17695 1155777006102 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1155777006103 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1155777006104 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777006105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777006106 putative substrate translocation pore; other site 1155777006107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777006108 dimerization interface [polypeptide binding]; other site 1155777006109 putative DNA binding site [nucleotide binding]; other site 1155777006110 putative Zn2+ binding site [ion binding]; other site 1155777006111 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1155777006112 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1155777006113 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1155777006114 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1155777006115 active site 1155777006116 dimer interface [polypeptide binding]; other site 1155777006117 motif 1; other site 1155777006118 motif 2; other site 1155777006119 motif 3; other site 1155777006120 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1155777006121 anticodon binding site; other site 1155777006122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777006123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777006124 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1155777006125 putative dimerization interface [polypeptide binding]; other site 1155777006126 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1155777006127 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1155777006128 NAD(P) binding site [chemical binding]; other site 1155777006129 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1155777006130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155777006131 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1155777006132 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1155777006133 active site 1155777006134 dimer interface [polypeptide binding]; other site 1155777006135 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1155777006136 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1155777006137 active site 1155777006138 FMN binding site [chemical binding]; other site 1155777006139 substrate binding site [chemical binding]; other site 1155777006140 3Fe-4S cluster binding site [ion binding]; other site 1155777006141 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1155777006142 domain interface; other site 1155777006143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777006144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777006145 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1155777006146 putative dimerization interface [polypeptide binding]; other site 1155777006147 gamma-glutamyl kinase; Provisional; Region: PRK13402 1155777006148 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1155777006149 nucleotide binding site [chemical binding]; other site 1155777006150 homotetrameric interface [polypeptide binding]; other site 1155777006151 putative phosphate binding site [ion binding]; other site 1155777006152 putative allosteric binding site; other site 1155777006153 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1155777006154 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1155777006155 Replication terminator protein; Region: RTP; pfam02334 1155777006156 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1155777006157 classical (c) SDRs; Region: SDR_c; cd05233 1155777006158 NAD(P) binding site [chemical binding]; other site 1155777006159 active site 1155777006160 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1155777006161 polyol permease family; Region: 2A0118; TIGR00897 1155777006162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777006163 putative substrate translocation pore; other site 1155777006164 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1155777006165 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1155777006166 nucleotide binding site [chemical binding]; other site 1155777006167 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1155777006168 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1155777006169 putative ligand binding site [chemical binding]; other site 1155777006170 putative NAD binding site [chemical binding]; other site 1155777006171 catalytic site [active] 1155777006172 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1155777006173 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1155777006174 putative [4Fe-4S] binding site [ion binding]; other site 1155777006175 putative molybdopterin cofactor binding site [chemical binding]; other site 1155777006176 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1155777006177 putative molybdopterin cofactor binding site; other site 1155777006178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777006179 MarR family; Region: MarR_2; pfam12802 1155777006180 MarR family; Region: MarR_2; cl17246 1155777006181 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1155777006182 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1155777006183 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1155777006184 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1155777006185 dimer interface [polypeptide binding]; other site 1155777006186 putative tRNA-binding site [nucleotide binding]; other site 1155777006187 Cupin domain; Region: Cupin_2; pfam07883 1155777006188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777006189 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155777006190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777006191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777006192 WHG domain; Region: WHG; pfam13305 1155777006193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155777006194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777006195 dimerization interface [polypeptide binding]; other site 1155777006196 putative DNA binding site [nucleotide binding]; other site 1155777006197 putative Zn2+ binding site [ion binding]; other site 1155777006198 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155777006199 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155777006200 catalytic residue [active] 1155777006201 Predicted membrane protein [Function unknown]; Region: COG2322 1155777006202 Protein required for attachment to host cells; Region: Host_attach; cl02398 1155777006203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155777006204 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1155777006205 putative dimer interface [polypeptide binding]; other site 1155777006206 catalytic triad [active] 1155777006207 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777006208 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777006209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1155777006210 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1155777006211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777006212 ATP binding site [chemical binding]; other site 1155777006213 putative Mg++ binding site [ion binding]; other site 1155777006214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777006215 nucleotide binding region [chemical binding]; other site 1155777006216 ATP-binding site [chemical binding]; other site 1155777006217 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1155777006218 HRDC domain; Region: HRDC; pfam00570 1155777006219 azoreductase; Provisional; Region: PRK13556 1155777006220 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1155777006221 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1155777006222 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1155777006223 putative dimer interface [polypeptide binding]; other site 1155777006224 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1155777006225 pentamer interface [polypeptide binding]; other site 1155777006226 dodecaamer interface [polypeptide binding]; other site 1155777006227 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1155777006228 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1155777006229 NAD(P) binding site [chemical binding]; other site 1155777006230 catalytic residues [active] 1155777006231 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1155777006232 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1155777006233 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1155777006234 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1155777006235 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1155777006236 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1155777006237 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1155777006238 Na2 binding site [ion binding]; other site 1155777006239 putative substrate binding site 1 [chemical binding]; other site 1155777006240 Na binding site 1 [ion binding]; other site 1155777006241 putative substrate binding site 2 [chemical binding]; other site 1155777006242 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1155777006243 Sodium Bile acid symporter family; Region: SBF; pfam01758 1155777006244 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155777006245 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1155777006246 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155777006247 E3 interaction surface; other site 1155777006248 lipoyl attachment site [posttranslational modification]; other site 1155777006249 e3 binding domain; Region: E3_binding; pfam02817 1155777006250 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155777006251 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1155777006252 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1155777006253 TPP-binding site [chemical binding]; other site 1155777006254 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1155777006255 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1155777006256 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1155777006257 metal ion-dependent adhesion site (MIDAS); other site 1155777006258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777006259 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155777006260 Walker A motif; other site 1155777006261 ATP binding site [chemical binding]; other site 1155777006262 Walker B motif; other site 1155777006263 arginine finger; other site 1155777006264 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1155777006265 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1155777006266 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1155777006267 E-class dimer interface [polypeptide binding]; other site 1155777006268 P-class dimer interface [polypeptide binding]; other site 1155777006269 active site 1155777006270 Cu2+ binding site [ion binding]; other site 1155777006271 Zn2+ binding site [ion binding]; other site 1155777006272 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777006273 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155777006274 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777006275 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155777006276 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777006277 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155777006278 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777006279 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155777006280 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155777006281 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1155777006282 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1155777006283 active site 1155777006284 TDP-binding site; other site 1155777006285 acceptor substrate-binding pocket; other site 1155777006286 homodimer interface [polypeptide binding]; other site 1155777006287 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1155777006288 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1155777006289 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1155777006290 multidrug efflux protein; Reviewed; Region: PRK01766 1155777006291 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1155777006292 cation binding site [ion binding]; other site 1155777006293 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1155777006294 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1155777006295 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1155777006296 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1155777006297 EamA-like transporter family; Region: EamA; pfam00892 1155777006298 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1155777006299 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155777006300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777006301 dimerization interface [polypeptide binding]; other site 1155777006302 putative DNA binding site [nucleotide binding]; other site 1155777006303 putative Zn2+ binding site [ion binding]; other site 1155777006304 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1155777006305 dimer interface [polypeptide binding]; other site 1155777006306 FMN binding site [chemical binding]; other site 1155777006307 Predicted esterase [General function prediction only]; Region: COG0400 1155777006308 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1155777006309 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777006310 Zn binding site [ion binding]; other site 1155777006311 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1155777006312 Zn binding site [ion binding]; other site 1155777006313 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1155777006314 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1155777006315 Na binding site [ion binding]; other site 1155777006316 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1155777006317 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1155777006318 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1155777006319 beta-galactosidase; Region: BGL; TIGR03356 1155777006320 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155777006321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777006322 DNA-binding site [nucleotide binding]; DNA binding site 1155777006323 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1155777006324 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1155777006325 C-terminal peptidase (prc); Region: prc; TIGR00225 1155777006326 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1155777006327 protein binding site [polypeptide binding]; other site 1155777006328 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1155777006329 Catalytic dyad [active] 1155777006330 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155777006331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777006332 S-adenosylmethionine binding site [chemical binding]; other site 1155777006333 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1155777006334 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1155777006335 similar to purine nucleoside phosphorylase, partial 1155777006336 similar to purine nucleoside phosphorylase, partial 1155777006337 YodL-like; Region: YodL; pfam14191 1155777006338 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1155777006339 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1155777006340 active site 1155777006341 YozD-like protein; Region: YozD; pfam14162 1155777006342 hypothetical protein; Provisional; Region: PRK13672 1155777006343 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1155777006344 Zn binding site [ion binding]; other site 1155777006345 toxin interface [polypeptide binding]; other site 1155777006346 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1155777006347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777006348 FeS/SAM binding site; other site 1155777006349 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1155777006350 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1155777006351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777006352 Coenzyme A binding pocket [chemical binding]; other site 1155777006353 acetylornithine deacetylase; Validated; Region: PRK06915 1155777006354 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1155777006355 metal binding site [ion binding]; metal-binding site 1155777006356 dimer interface [polypeptide binding]; other site 1155777006357 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1155777006358 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1155777006359 hypothetical protein; Provisional; Region: PRK06917 1155777006360 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777006361 inhibitor-cofactor binding pocket; inhibition site 1155777006362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777006363 catalytic residue [active] 1155777006364 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1155777006365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777006366 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155777006367 Coenzyme A binding pocket [chemical binding]; other site 1155777006368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155777006369 active site 1155777006370 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1155777006371 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1155777006372 Phytase; Region: Phytase; cl17685 1155777006373 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1155777006374 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1155777006375 NAD(P) binding site [chemical binding]; other site 1155777006376 homodimer interface [polypeptide binding]; other site 1155777006377 substrate binding site [chemical binding]; other site 1155777006378 active site 1155777006379 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1155777006380 SelR domain; Region: SelR; pfam01641 1155777006381 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1155777006382 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777006383 MarR family; Region: MarR; pfam01047 1155777006384 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1155777006385 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1155777006386 active site 1155777006387 catalytic triad [active] 1155777006388 oxyanion hole [active] 1155777006389 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1155777006390 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1155777006391 Cu(I) binding site [ion binding]; other site 1155777006392 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1155777006393 threonine dehydratase; Validated; Region: PRK08639 1155777006394 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1155777006395 tetramer interface [polypeptide binding]; other site 1155777006396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777006397 catalytic residue [active] 1155777006398 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1155777006399 putative Ile/Val binding site [chemical binding]; other site 1155777006400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777006401 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155777006402 Walker A motif; other site 1155777006403 ATP binding site [chemical binding]; other site 1155777006404 Walker B motif; other site 1155777006405 arginine finger; other site 1155777006406 Haemolysin-III related; Region: HlyIII; cl03831 1155777006407 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1155777006408 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1155777006409 putative acyl-acceptor binding pocket; other site 1155777006410 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155777006411 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1155777006412 folate binding site [chemical binding]; other site 1155777006413 NADP+ binding site [chemical binding]; other site 1155777006414 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1155777006415 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1155777006416 dimerization interface [polypeptide binding]; other site 1155777006417 active site 1155777006418 YpjP-like protein; Region: YpjP; pfam14005 1155777006419 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1155777006420 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1155777006421 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1155777006422 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1155777006423 Virulence factor; Region: Virulence_fact; pfam13769 1155777006424 HEAT repeats; Region: HEAT_2; pfam13646 1155777006425 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1155777006426 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1155777006427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155777006428 Zn2+ binding site [ion binding]; other site 1155777006429 Mg2+ binding site [ion binding]; other site 1155777006430 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1155777006431 catalytic residues [active] 1155777006432 dimer interface [polypeptide binding]; other site 1155777006433 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1155777006434 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1155777006435 proposed active site lysine [active] 1155777006436 conserved cys residue [active] 1155777006437 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1155777006438 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1155777006439 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155777006440 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155777006441 DNA-binding site [nucleotide binding]; DNA binding site 1155777006442 RNA-binding motif; other site 1155777006443 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1155777006444 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1155777006445 hypothetical protein; Validated; Region: PRK07708 1155777006446 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1155777006447 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155777006448 active site 1155777006449 conserved hypothetical integral membrane protein; Region: TIGR00697 1155777006450 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1155777006451 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155777006452 active site 1155777006453 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1155777006454 5'-3' exonuclease; Region: 53EXOc; smart00475 1155777006455 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1155777006456 active site 1155777006457 metal binding site 1 [ion binding]; metal-binding site 1155777006458 putative 5' ssDNA interaction site; other site 1155777006459 metal binding site 3; metal-binding site 1155777006460 metal binding site 2 [ion binding]; metal-binding site 1155777006461 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1155777006462 putative DNA binding site [nucleotide binding]; other site 1155777006463 putative metal binding site [ion binding]; other site 1155777006464 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1155777006465 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1155777006466 Dynamin family; Region: Dynamin_N; pfam00350 1155777006467 G1 box; other site 1155777006468 GTP/Mg2+ binding site [chemical binding]; other site 1155777006469 G2 box; other site 1155777006470 Switch I region; other site 1155777006471 G3 box; other site 1155777006472 Switch II region; other site 1155777006473 G4 box; other site 1155777006474 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1155777006475 G1 box; other site 1155777006476 GTP/Mg2+ binding site [chemical binding]; other site 1155777006477 Dynamin family; Region: Dynamin_N; pfam00350 1155777006478 G2 box; other site 1155777006479 Switch I region; other site 1155777006480 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1155777006481 G3 box; other site 1155777006482 Switch II region; other site 1155777006483 GTP/Mg2+ binding site [chemical binding]; other site 1155777006484 G4 box; other site 1155777006485 G5 box; other site 1155777006486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1155777006487 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1155777006488 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1155777006489 malonyl-CoA binding site [chemical binding]; other site 1155777006490 dimer interface [polypeptide binding]; other site 1155777006491 active site 1155777006492 product binding site; other site 1155777006493 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155777006494 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1155777006495 DNA binding site [nucleotide binding] 1155777006496 active site 1155777006497 Protein of unknown function (DUF421); Region: DUF421; cl00990 1155777006498 Isochorismatase family; Region: Isochorismatase; pfam00857 1155777006499 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1155777006500 catalytic triad [active] 1155777006501 conserved cis-peptide bond; other site 1155777006502 Helix-turn-helix domain; Region: HTH_17; pfam12728 1155777006503 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1155777006504 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155777006505 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155777006506 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155777006507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777006508 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155777006509 amidase catalytic site [active] 1155777006510 Zn binding residues [ion binding]; other site 1155777006511 substrate binding site [chemical binding]; other site 1155777006512 Bacterial SH3 domain; Region: SH3_3; cl17532 1155777006513 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1155777006514 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155777006515 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1155777006516 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1155777006517 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1155777006518 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1155777006519 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1155777006520 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1155777006521 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155777006522 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1155777006523 Phage tail protein; Region: Sipho_tail; pfam05709 1155777006524 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1155777006525 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155777006526 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155777006527 catalytic residue [active] 1155777006528 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1155777006529 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1155777006530 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1155777006531 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1155777006532 oligomerization interface [polypeptide binding]; other site 1155777006533 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1155777006534 Phage capsid family; Region: Phage_capsid; pfam05065 1155777006535 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1155777006536 Phage-related protein [Function unknown]; Region: COG4695 1155777006537 Phage portal protein; Region: Phage_portal; pfam04860 1155777006538 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1155777006539 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1155777006540 HNH endonuclease; Region: HNH; pfam01844 1155777006541 active site 1155777006542 Helix-turn-helix domain; Region: HTH_17; pfam12728 1155777006543 positive control sigma-like factor; Validated; Region: PRK06930 1155777006544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777006545 DNA binding residues [nucleotide binding] 1155777006546 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1155777006547 hypothetical protein; Provisional; Region: PRK06921 1155777006548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777006549 Walker A motif; other site 1155777006550 ATP binding site [chemical binding]; other site 1155777006551 Walker B motif; other site 1155777006552 arginine finger; other site 1155777006553 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1155777006554 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1155777006555 Hypothetical protein Yqai; Region: Yqai; pfam09466 1155777006556 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1155777006557 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1155777006558 transcriptional repressor DicA; Reviewed; Region: PRK09706 1155777006559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777006560 non-specific DNA binding site [nucleotide binding]; other site 1155777006561 salt bridge; other site 1155777006562 sequence-specific DNA binding site [nucleotide binding]; other site 1155777006563 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1155777006564 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155777006565 Int/Topo IB signature motif; other site 1155777006566 xanthine permease; Region: pbuX; TIGR03173 1155777006567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777006568 active site 1155777006569 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1155777006570 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1155777006571 active site 1155777006572 Zn binding site [ion binding]; other site 1155777006573 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1155777006574 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1155777006575 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1155777006576 YpzG-like protein; Region: YpzG; pfam14139 1155777006577 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1155777006578 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1155777006579 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1155777006580 cell division protein GpsB; Provisional; Region: PRK14127 1155777006581 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155777006582 hypothetical protein; Provisional; Region: PRK13660 1155777006583 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1155777006584 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1155777006585 RNase_H superfamily; Region: RNase_H_2; pfam13482 1155777006586 active site 1155777006587 substrate binding site [chemical binding]; other site 1155777006588 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1155777006589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777006590 ATP binding site [chemical binding]; other site 1155777006591 putative Mg++ binding site [ion binding]; other site 1155777006592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777006593 nucleotide binding region [chemical binding]; other site 1155777006594 ATP-binding site [chemical binding]; other site 1155777006595 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1155777006596 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155777006597 HPr interaction site; other site 1155777006598 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155777006599 active site 1155777006600 phosphorylation site [posttranslational modification] 1155777006601 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1155777006602 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1155777006603 YppG-like protein; Region: YppG; pfam14179 1155777006604 YppF-like protein; Region: YppF; pfam14178 1155777006605 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1155777006606 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1155777006607 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1155777006608 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1155777006609 Transglycosylase; Region: Transgly; pfam00912 1155777006610 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155777006611 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1155777006612 Interdomain contacts; other site 1155777006613 Cytokine receptor motif; other site 1155777006614 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1155777006615 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155777006616 minor groove reading motif; other site 1155777006617 helix-hairpin-helix signature motif; other site 1155777006618 substrate binding pocket [chemical binding]; other site 1155777006619 active site 1155777006620 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1155777006621 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1155777006622 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1155777006623 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1155777006624 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1155777006625 putative dimer interface [polypeptide binding]; other site 1155777006626 putative anticodon binding site; other site 1155777006627 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1155777006628 homodimer interface [polypeptide binding]; other site 1155777006629 motif 1; other site 1155777006630 motif 2; other site 1155777006631 active site 1155777006632 motif 3; other site 1155777006633 aspartate aminotransferase; Provisional; Region: PRK05764 1155777006634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777006635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777006636 homodimer interface [polypeptide binding]; other site 1155777006637 catalytic residue [active] 1155777006638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1155777006639 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155777006640 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1155777006641 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1155777006642 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1155777006643 active site 1155777006644 catalytic site [active] 1155777006645 substrate binding site [chemical binding]; other site 1155777006646 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1155777006647 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1155777006648 tetramerization interface [polypeptide binding]; other site 1155777006649 active site 1155777006650 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1155777006651 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1155777006652 active site 1155777006653 ATP-binding site [chemical binding]; other site 1155777006654 pantoate-binding site; other site 1155777006655 HXXH motif; other site 1155777006656 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1155777006657 oligomerization interface [polypeptide binding]; other site 1155777006658 active site 1155777006659 metal binding site [ion binding]; metal-binding site 1155777006660 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1155777006661 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1155777006662 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1155777006663 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1155777006664 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1155777006665 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1155777006666 active site 1155777006667 NTP binding site [chemical binding]; other site 1155777006668 metal binding triad [ion binding]; metal-binding site 1155777006669 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1155777006670 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1155777006671 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1155777006672 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1155777006673 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1155777006674 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1155777006675 active site 1155777006676 dimer interfaces [polypeptide binding]; other site 1155777006677 catalytic residues [active] 1155777006678 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1155777006679 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1155777006680 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1155777006681 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1155777006682 homodimer interface [polypeptide binding]; other site 1155777006683 metal binding site [ion binding]; metal-binding site 1155777006684 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155777006685 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777006686 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777006687 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155777006688 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1155777006689 Cupin; Region: Cupin_1; smart00835 1155777006690 Cupin; Region: Cupin_1; smart00835 1155777006691 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 1155777006692 Predicted membrane protein [Function unknown]; Region: COG4347 1155777006693 Qo binding site; other site 1155777006694 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1155777006695 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1155777006696 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1155777006697 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1155777006698 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1155777006699 interchain domain interface [polypeptide binding]; other site 1155777006700 intrachain domain interface; other site 1155777006701 heme bH binding site [chemical binding]; other site 1155777006702 Qi binding site; other site 1155777006703 heme bL binding site [chemical binding]; other site 1155777006704 Qo binding site; other site 1155777006705 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1155777006706 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1155777006707 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1155777006708 iron-sulfur cluster [ion binding]; other site 1155777006709 [2Fe-2S] cluster binding site [ion binding]; other site 1155777006710 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1155777006711 hypothetical protein; Provisional; Region: PRK03636 1155777006712 UPF0302 domain; Region: UPF0302; pfam08864 1155777006713 A short protein domain of unknown function; Region: IDEAL; smart00914 1155777006714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1155777006715 TPR motif; other site 1155777006716 binding surface 1155777006717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1155777006718 binding surface 1155777006719 TPR motif; other site 1155777006720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777006721 TPR motif; other site 1155777006722 binding surface 1155777006723 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1155777006724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777006725 binding surface 1155777006726 TPR motif; other site 1155777006727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1155777006728 binding surface 1155777006729 TPR motif; other site 1155777006730 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1155777006731 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1155777006732 hinge; other site 1155777006733 active site 1155777006734 prephenate dehydrogenase; Validated; Region: PRK06545 1155777006735 prephenate dehydrogenase; Validated; Region: PRK08507 1155777006736 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1155777006737 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1155777006738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777006739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777006740 homodimer interface [polypeptide binding]; other site 1155777006741 catalytic residue [active] 1155777006742 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1155777006743 substrate binding site [chemical binding]; other site 1155777006744 active site 1155777006745 catalytic residues [active] 1155777006746 heterodimer interface [polypeptide binding]; other site 1155777006747 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1155777006748 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1155777006749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777006750 catalytic residue [active] 1155777006751 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1155777006752 active site 1155777006753 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1155777006754 active site 1155777006755 ribulose/triose binding site [chemical binding]; other site 1155777006756 phosphate binding site [ion binding]; other site 1155777006757 substrate (anthranilate) binding pocket [chemical binding]; other site 1155777006758 product (indole) binding pocket [chemical binding]; other site 1155777006759 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1155777006760 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1155777006761 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1155777006762 anthranilate synthase component I; Provisional; Region: PRK13569 1155777006763 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1155777006764 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1155777006765 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1155777006766 homotrimer interaction site [polypeptide binding]; other site 1155777006767 active site 1155777006768 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1155777006769 active site 1155777006770 dimer interface [polypeptide binding]; other site 1155777006771 metal binding site [ion binding]; metal-binding site 1155777006772 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1155777006773 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1155777006774 Tetramer interface [polypeptide binding]; other site 1155777006775 active site 1155777006776 FMN-binding site [chemical binding]; other site 1155777006777 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1155777006778 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1155777006779 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1155777006780 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1155777006781 active site 1155777006782 multimer interface [polypeptide binding]; other site 1155777006783 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1155777006784 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1155777006785 substrate binding pocket [chemical binding]; other site 1155777006786 chain length determination region; other site 1155777006787 substrate-Mg2+ binding site; other site 1155777006788 catalytic residues [active] 1155777006789 aspartate-rich region 1; other site 1155777006790 active site lid residues [active] 1155777006791 aspartate-rich region 2; other site 1155777006792 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1155777006793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777006794 S-adenosylmethionine binding site [chemical binding]; other site 1155777006795 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1155777006796 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1155777006797 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1155777006798 homodecamer interface [polypeptide binding]; other site 1155777006799 GTP cyclohydrolase I; Provisional; Region: PLN03044 1155777006800 active site 1155777006801 putative catalytic site residues [active] 1155777006802 zinc binding site [ion binding]; other site 1155777006803 GTP-CH-I/GFRP interaction surface; other site 1155777006804 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1155777006805 IHF dimer interface [polypeptide binding]; other site 1155777006806 IHF - DNA interface [nucleotide binding]; other site 1155777006807 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1155777006808 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1155777006809 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1155777006810 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1155777006811 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1155777006812 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1155777006813 GTP-binding protein Der; Reviewed; Region: PRK00093 1155777006814 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1155777006815 G1 box; other site 1155777006816 GTP/Mg2+ binding site [chemical binding]; other site 1155777006817 Switch I region; other site 1155777006818 G2 box; other site 1155777006819 Switch II region; other site 1155777006820 G3 box; other site 1155777006821 G4 box; other site 1155777006822 G5 box; other site 1155777006823 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1155777006824 G1 box; other site 1155777006825 GTP/Mg2+ binding site [chemical binding]; other site 1155777006826 Switch I region; other site 1155777006827 G2 box; other site 1155777006828 G3 box; other site 1155777006829 Switch II region; other site 1155777006830 G4 box; other site 1155777006831 G5 box; other site 1155777006832 YpzI-like protein; Region: YpzI; pfam14140 1155777006833 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1155777006834 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1155777006835 homotetramer interface [polypeptide binding]; other site 1155777006836 FMN binding site [chemical binding]; other site 1155777006837 homodimer contacts [polypeptide binding]; other site 1155777006838 putative active site [active] 1155777006839 putative substrate binding site [chemical binding]; other site 1155777006840 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1155777006841 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1155777006842 RNA binding site [nucleotide binding]; other site 1155777006843 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1155777006844 RNA binding site [nucleotide binding]; other site 1155777006845 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1155777006846 RNA binding site [nucleotide binding]; other site 1155777006847 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155777006848 RNA binding site [nucleotide binding]; other site 1155777006849 cytidylate kinase; Provisional; Region: cmk; PRK00023 1155777006850 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1155777006851 CMP-binding site; other site 1155777006852 The sites determining sugar specificity; other site 1155777006853 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1155777006854 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1155777006855 PilZ domain; Region: PilZ; pfam07238 1155777006856 germination protein YpeB; Region: spore_YpeB; TIGR02889 1155777006857 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1155777006858 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155777006859 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1155777006860 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1155777006861 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1155777006862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1155777006863 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1155777006864 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1155777006865 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1155777006866 NAD(P) binding site [chemical binding]; other site 1155777006867 adaptor protein; Provisional; Region: PRK02899 1155777006868 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1155777006869 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155777006870 putative active site [active] 1155777006871 putative metal binding site [ion binding]; other site 1155777006872 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1155777006873 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155777006874 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777006875 CAAX protease self-immunity; Region: Abi; pfam02517 1155777006876 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1155777006877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777006878 ATP binding site [chemical binding]; other site 1155777006879 putative Mg++ binding site [ion binding]; other site 1155777006880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777006881 nucleotide binding region [chemical binding]; other site 1155777006882 ATP-binding site [chemical binding]; other site 1155777006883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1155777006884 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1155777006885 Predicted membrane protein [Function unknown]; Region: COG3601 1155777006886 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155777006887 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1155777006888 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1155777006889 ligand binding site [chemical binding]; other site 1155777006890 NAD binding site [chemical binding]; other site 1155777006891 dimerization interface [polypeptide binding]; other site 1155777006892 catalytic site [active] 1155777006893 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1155777006894 putative L-serine binding site [chemical binding]; other site 1155777006895 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1155777006896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777006897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777006898 DNA binding residues [nucleotide binding] 1155777006899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1155777006900 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777006901 dimerization interface [polypeptide binding]; other site 1155777006902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777006903 putative active site [active] 1155777006904 heme pocket [chemical binding]; other site 1155777006905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777006906 dimer interface [polypeptide binding]; other site 1155777006907 phosphorylation site [posttranslational modification] 1155777006908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777006909 ATP binding site [chemical binding]; other site 1155777006910 Mg2+ binding site [ion binding]; other site 1155777006911 G-X-G motif; other site 1155777006912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777006913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777006914 active site 1155777006915 phosphorylation site [posttranslational modification] 1155777006916 intermolecular recognition site; other site 1155777006917 dimerization interface [polypeptide binding]; other site 1155777006918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777006919 DNA binding site [nucleotide binding] 1155777006920 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1155777006921 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1155777006922 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1155777006923 ResB-like family; Region: ResB; pfam05140 1155777006924 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1155777006925 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155777006926 catalytic residues [active] 1155777006927 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155777006928 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777006929 RNA binding surface [nucleotide binding]; other site 1155777006930 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1155777006931 active site 1155777006932 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1155777006933 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1155777006934 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1155777006935 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1155777006936 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1155777006937 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1155777006938 segregation and condensation protein B; Region: TIGR00281 1155777006939 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1155777006940 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1155777006941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777006942 Coenzyme A binding pocket [chemical binding]; other site 1155777006943 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1155777006944 homopentamer interface [polypeptide binding]; other site 1155777006945 active site 1155777006946 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1155777006947 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1155777006948 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1155777006949 dimerization interface [polypeptide binding]; other site 1155777006950 active site 1155777006951 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1155777006952 Lumazine binding domain; Region: Lum_binding; pfam00677 1155777006953 Lumazine binding domain; Region: Lum_binding; pfam00677 1155777006954 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1155777006955 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1155777006956 catalytic motif [active] 1155777006957 Zn binding site [ion binding]; other site 1155777006958 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1155777006959 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155777006960 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155777006961 Catalytic site [active] 1155777006962 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1155777006963 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1155777006964 active site 1155777006965 Predicted secreted protein [Function unknown]; Region: COG4086 1155777006966 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1155777006967 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1155777006968 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1155777006969 active site 1155777006970 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155777006971 substrate binding site [chemical binding]; other site 1155777006972 catalytic residues [active] 1155777006973 dimer interface [polypeptide binding]; other site 1155777006974 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1155777006975 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1155777006976 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1155777006977 stage V sporulation protein AD; Validated; Region: PRK08304 1155777006978 stage V sporulation protein AD; Provisional; Region: PRK12404 1155777006979 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1155777006980 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1155777006981 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1155777006982 sporulation sigma factor SigF; Validated; Region: PRK05572 1155777006983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777006984 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155777006985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777006986 DNA binding residues [nucleotide binding] 1155777006987 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1155777006988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777006989 ATP binding site [chemical binding]; other site 1155777006990 Mg2+ binding site [ion binding]; other site 1155777006991 G-X-G motif; other site 1155777006992 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1155777006993 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1155777006994 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1155777006995 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1155777006996 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1155777006997 phosphopentomutase; Provisional; Region: PRK05362 1155777006998 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1155777006999 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1155777007000 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1155777007001 active site 1155777007002 Int/Topo IB signature motif; other site 1155777007003 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1155777007004 ferric uptake regulator; Provisional; Region: fur; PRK09462 1155777007005 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155777007006 metal binding site 2 [ion binding]; metal-binding site 1155777007007 putative DNA binding helix; other site 1155777007008 metal binding site 1 [ion binding]; metal-binding site 1155777007009 dimer interface [polypeptide binding]; other site 1155777007010 structural Zn2+ binding site [ion binding]; other site 1155777007011 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1155777007012 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1155777007013 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1155777007014 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1155777007015 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1155777007016 NAD(P) binding pocket [chemical binding]; other site 1155777007017 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1155777007018 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1155777007019 Aspartase; Region: Aspartase; cd01357 1155777007020 active sites [active] 1155777007021 tetramer interface [polypeptide binding]; other site 1155777007022 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1155777007023 active site 1155777007024 homodimer interface [polypeptide binding]; other site 1155777007025 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155777007026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777007027 non-specific DNA binding site [nucleotide binding]; other site 1155777007028 salt bridge; other site 1155777007029 sequence-specific DNA binding site [nucleotide binding]; other site 1155777007030 TIGR00375 family protein; Region: TIGR00375 1155777007031 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1155777007032 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1155777007033 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1155777007034 dimer interface [polypeptide binding]; other site 1155777007035 ADP-ribose binding site [chemical binding]; other site 1155777007036 active site 1155777007037 nudix motif; other site 1155777007038 metal binding site [ion binding]; metal-binding site 1155777007039 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1155777007040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155777007041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155777007042 active site 1155777007043 catalytic tetrad [active] 1155777007044 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155777007045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155777007046 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1155777007047 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1155777007048 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1155777007049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1155777007050 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155777007051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777007052 Coenzyme A binding pocket [chemical binding]; other site 1155777007053 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1155777007054 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1155777007055 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155777007056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777007057 Coenzyme A binding pocket [chemical binding]; other site 1155777007058 DNA polymerase IV; Reviewed; Region: PRK03103 1155777007059 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1155777007060 active site 1155777007061 DNA binding site [nucleotide binding] 1155777007062 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1155777007063 YolD-like protein; Region: YolD; pfam08863 1155777007064 YqzH-like protein; Region: YqzH; pfam14164 1155777007065 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155777007066 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155777007067 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1155777007068 putative dimer interface [polypeptide binding]; other site 1155777007069 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777007070 ligand binding site [chemical binding]; other site 1155777007071 Zn binding site [ion binding]; other site 1155777007072 pantothenate kinase; Provisional; Region: PRK05439 1155777007073 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1155777007074 ATP-binding site [chemical binding]; other site 1155777007075 CoA-binding site [chemical binding]; other site 1155777007076 Mg2+-binding site [ion binding]; other site 1155777007077 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1155777007078 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1155777007079 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155777007080 catalytic residue [active] 1155777007081 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1155777007082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155777007083 NAD(P) binding site [chemical binding]; other site 1155777007084 active site 1155777007085 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1155777007086 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1155777007087 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1155777007088 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1155777007089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155777007090 substrate binding site [chemical binding]; other site 1155777007091 oxyanion hole (OAH) forming residues; other site 1155777007092 trimer interface [polypeptide binding]; other site 1155777007093 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1155777007094 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1155777007095 dimer interface [polypeptide binding]; other site 1155777007096 active site 1155777007097 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1155777007098 Cytochrome P450; Region: p450; cl12078 1155777007099 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1155777007100 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1155777007101 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007102 polyketide synthase; Region: polyketide_synthase; cd08251 1155777007103 Enoylreductase; Region: PKS_ER; smart00829 1155777007104 putative NAD(P) binding site [chemical binding]; other site 1155777007105 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007106 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007107 active site 1155777007108 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007109 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007110 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1155777007111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007112 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007113 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777007114 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007115 active site 1155777007116 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007117 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007118 putative NADP binding site [chemical binding]; other site 1155777007119 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777007120 active site 1155777007121 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007122 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007123 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007124 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777007125 putative NADP binding site [chemical binding]; other site 1155777007126 active site 1155777007127 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007128 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007129 active site 1155777007130 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007131 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777007132 putative NADP binding site [chemical binding]; other site 1155777007133 active site 1155777007134 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007135 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007136 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007137 active site 1155777007138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777007139 S-adenosylmethionine binding site [chemical binding]; other site 1155777007140 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007141 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007142 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007143 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007144 active site 1155777007145 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007146 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007147 KR domain; Region: KR; pfam08659 1155777007148 putative NADP binding site [chemical binding]; other site 1155777007149 active site 1155777007150 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007151 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007152 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007153 active site 1155777007154 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007155 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007156 putative NADP binding site [chemical binding]; other site 1155777007157 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777007158 active site 1155777007159 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007160 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777007161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007162 active site 1155777007163 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007164 putative NADP binding site [chemical binding]; other site 1155777007165 active site 1155777007166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007167 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007168 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007169 active site 1155777007170 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007171 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007172 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007173 active site 1155777007174 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007175 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1155777007176 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007177 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007178 putative NADP binding site [chemical binding]; other site 1155777007179 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777007180 active site 1155777007181 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007182 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007183 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007184 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007185 active site 1155777007186 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007187 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777007188 putative NADP binding site [chemical binding]; other site 1155777007189 active site 1155777007190 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007191 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007192 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007193 active site 1155777007194 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007195 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007196 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007197 active site 1155777007198 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007199 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007200 putative NADP binding site [chemical binding]; other site 1155777007201 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777007202 active site 1155777007203 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1155777007204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777007205 S-adenosylmethionine binding site [chemical binding]; other site 1155777007206 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1155777007207 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007208 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007209 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1155777007210 active site 1155777007211 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1155777007212 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1155777007213 putative NADP binding site [chemical binding]; other site 1155777007214 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1155777007215 active site 1155777007216 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777007217 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1155777007218 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1155777007219 active site 1155777007220 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1155777007221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155777007222 NAD(P) binding site [chemical binding]; other site 1155777007223 active site 1155777007224 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1155777007225 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1155777007226 acyl-activating enzyme (AAE) consensus motif; other site 1155777007227 active site 1155777007228 AMP binding site [chemical binding]; other site 1155777007229 CoA binding site [chemical binding]; other site 1155777007230 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1155777007231 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 1155777007232 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155777007233 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155777007234 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1155777007235 FMN binding site [chemical binding]; other site 1155777007236 substrate binding site [chemical binding]; other site 1155777007237 putative catalytic residue [active] 1155777007238 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1155777007239 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1155777007240 Cupin domain; Region: Cupin_2; pfam07883 1155777007241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777007242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777007243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777007244 dimerization interface [polypeptide binding]; other site 1155777007245 GlpM protein; Region: GlpM; cl01212 1155777007246 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1155777007247 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1155777007248 active site 1155777007249 FMN binding site [chemical binding]; other site 1155777007250 substrate binding site [chemical binding]; other site 1155777007251 homotetramer interface [polypeptide binding]; other site 1155777007252 catalytic residue [active] 1155777007253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155777007254 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1155777007255 ribonuclease Z; Region: RNase_Z; TIGR02651 1155777007256 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1155777007257 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1155777007258 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1155777007259 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1155777007260 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1155777007261 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1155777007262 DNA polymerase IV; Validated; Region: PRK01810 1155777007263 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1155777007264 active site 1155777007265 DNA binding site [nucleotide binding] 1155777007266 OxaA-like protein precursor; Validated; Region: PRK01622 1155777007267 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1155777007268 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1155777007269 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1155777007270 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1155777007271 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1155777007272 peptidase T-like protein; Region: PepT-like; TIGR01883 1155777007273 metal binding site [ion binding]; metal-binding site 1155777007274 putative dimer interface [polypeptide binding]; other site 1155777007275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777007276 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1155777007277 dimer interface [polypeptide binding]; other site 1155777007278 substrate binding site [chemical binding]; other site 1155777007279 metal binding site [ion binding]; metal-binding site 1155777007280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1155777007281 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1155777007282 Predicted membrane protein [Function unknown]; Region: COG4129 1155777007283 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1155777007284 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1155777007285 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155777007286 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155777007287 Walker A/P-loop; other site 1155777007288 ATP binding site [chemical binding]; other site 1155777007289 Q-loop/lid; other site 1155777007290 ABC transporter signature motif; other site 1155777007291 Walker B; other site 1155777007292 D-loop; other site 1155777007293 H-loop/switch region; other site 1155777007294 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155777007295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777007296 dimer interface [polypeptide binding]; other site 1155777007297 conserved gate region; other site 1155777007298 putative PBP binding loops; other site 1155777007299 ABC-ATPase subunit interface; other site 1155777007300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155777007301 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155777007302 substrate binding pocket [chemical binding]; other site 1155777007303 membrane-bound complex binding site; other site 1155777007304 hinge residues; other site 1155777007305 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1155777007306 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1155777007307 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155777007308 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1155777007309 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155777007310 E3 interaction surface; other site 1155777007311 lipoyl attachment site [posttranslational modification]; other site 1155777007312 e3 binding domain; Region: E3_binding; pfam02817 1155777007313 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155777007314 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1155777007315 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1155777007316 alpha subunit interface [polypeptide binding]; other site 1155777007317 TPP binding site [chemical binding]; other site 1155777007318 heterodimer interface [polypeptide binding]; other site 1155777007319 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155777007320 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1155777007321 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1155777007322 tetramer interface [polypeptide binding]; other site 1155777007323 TPP-binding site [chemical binding]; other site 1155777007324 heterodimer interface [polypeptide binding]; other site 1155777007325 phosphorylation loop region [posttranslational modification] 1155777007326 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1155777007327 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1155777007328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777007329 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155777007330 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155777007331 nucleotide binding site [chemical binding]; other site 1155777007332 Acetokinase family; Region: Acetate_kinase; cl17229 1155777007333 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1155777007334 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1155777007335 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1155777007336 NAD binding site [chemical binding]; other site 1155777007337 Phe binding site; other site 1155777007338 phosphate butyryltransferase; Validated; Region: PRK07742 1155777007339 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155777007340 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1155777007341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777007342 putative active site [active] 1155777007343 heme pocket [chemical binding]; other site 1155777007344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777007345 putative active site [active] 1155777007346 heme pocket [chemical binding]; other site 1155777007347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777007348 Walker A motif; other site 1155777007349 ATP binding site [chemical binding]; other site 1155777007350 Walker B motif; other site 1155777007351 arginine finger; other site 1155777007352 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1155777007353 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1155777007354 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1155777007355 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1155777007356 tetramer interface [polypeptide binding]; other site 1155777007357 active site 1155777007358 Mg2+/Mn2+ binding site [ion binding]; other site 1155777007359 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1155777007360 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1155777007361 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1155777007362 dimer interface [polypeptide binding]; other site 1155777007363 Citrate synthase; Region: Citrate_synt; pfam00285 1155777007364 active site 1155777007365 coenzyme A binding site [chemical binding]; other site 1155777007366 citrylCoA binding site [chemical binding]; other site 1155777007367 oxalacetate/citrate binding site [chemical binding]; other site 1155777007368 catalytic triad [active] 1155777007369 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1155777007370 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1155777007371 FAD binding site [chemical binding]; other site 1155777007372 homotetramer interface [polypeptide binding]; other site 1155777007373 substrate binding pocket [chemical binding]; other site 1155777007374 catalytic base [active] 1155777007375 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1155777007376 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1155777007377 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1155777007378 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1155777007379 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1155777007380 dimer interface [polypeptide binding]; other site 1155777007381 active site 1155777007382 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155777007383 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1155777007384 active site 1155777007385 catalytic site [active] 1155777007386 metal binding site [ion binding]; metal-binding site 1155777007387 dimer interface [polypeptide binding]; other site 1155777007388 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1155777007389 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1155777007390 active site 1155777007391 metal binding site [ion binding]; metal-binding site 1155777007392 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1155777007393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777007394 sequence-specific DNA binding site [nucleotide binding]; other site 1155777007395 salt bridge; other site 1155777007396 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1155777007397 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1155777007398 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1155777007399 putative active site [active] 1155777007400 putative FMN binding site [chemical binding]; other site 1155777007401 putative substrate binding site [chemical binding]; other site 1155777007402 putative catalytic residue [active] 1155777007403 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1155777007404 alanine racemase; Region: alr; TIGR00492 1155777007405 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1155777007406 active site 1155777007407 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155777007408 dimer interface [polypeptide binding]; other site 1155777007409 substrate binding site [chemical binding]; other site 1155777007410 catalytic residues [active] 1155777007411 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1155777007412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777007413 active site 1155777007414 phosphorylation site [posttranslational modification] 1155777007415 intermolecular recognition site; other site 1155777007416 dimerization interface [polypeptide binding]; other site 1155777007417 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1155777007418 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1155777007419 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1155777007420 protein binding site [polypeptide binding]; other site 1155777007421 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1155777007422 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1155777007423 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1155777007424 Walker A/P-loop; other site 1155777007425 ATP binding site [chemical binding]; other site 1155777007426 Q-loop/lid; other site 1155777007427 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1155777007428 ABC transporter signature motif; other site 1155777007429 Walker B; other site 1155777007430 D-loop; other site 1155777007431 H-loop/switch region; other site 1155777007432 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1155777007433 arginine repressor; Provisional; Region: PRK04280 1155777007434 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155777007435 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1155777007436 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777007437 RNA binding surface [nucleotide binding]; other site 1155777007438 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1155777007439 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1155777007440 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1155777007441 TPP-binding site; other site 1155777007442 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1155777007443 PYR/PP interface [polypeptide binding]; other site 1155777007444 dimer interface [polypeptide binding]; other site 1155777007445 TPP binding site [chemical binding]; other site 1155777007446 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155777007447 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1155777007448 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1155777007449 substrate binding pocket [chemical binding]; other site 1155777007450 chain length determination region; other site 1155777007451 substrate-Mg2+ binding site; other site 1155777007452 catalytic residues [active] 1155777007453 aspartate-rich region 1; other site 1155777007454 active site lid residues [active] 1155777007455 aspartate-rich region 2; other site 1155777007456 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1155777007457 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1155777007458 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1155777007459 generic binding surface II; other site 1155777007460 generic binding surface I; other site 1155777007461 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1155777007462 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1155777007463 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1155777007464 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1155777007465 homodimer interface [polypeptide binding]; other site 1155777007466 NADP binding site [chemical binding]; other site 1155777007467 substrate binding site [chemical binding]; other site 1155777007468 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1155777007469 putative RNA binding site [nucleotide binding]; other site 1155777007470 Asp23 family; Region: Asp23; pfam03780 1155777007471 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1155777007472 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155777007473 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155777007474 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1155777007475 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1155777007476 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155777007477 carboxyltransferase (CT) interaction site; other site 1155777007478 biotinylation site [posttranslational modification]; other site 1155777007479 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1155777007480 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1155777007481 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1155777007482 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1155777007483 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1155777007484 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1155777007485 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1155777007486 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1155777007487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777007488 Walker A motif; other site 1155777007489 ATP binding site [chemical binding]; other site 1155777007490 Walker B motif; other site 1155777007491 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1155777007492 elongation factor P; Validated; Region: PRK00529 1155777007493 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1155777007494 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1155777007495 RNA binding site [nucleotide binding]; other site 1155777007496 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1155777007497 RNA binding site [nucleotide binding]; other site 1155777007498 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1155777007499 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1155777007500 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1155777007501 active site 1155777007502 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1155777007503 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1155777007504 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1155777007505 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1155777007506 active site 1155777007507 nucleophile elbow; other site 1155777007508 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1155777007509 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1155777007510 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1155777007511 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155777007512 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155777007513 active site residue [active] 1155777007514 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1155777007515 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1155777007516 tetramer interface [polypeptide binding]; other site 1155777007517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777007518 catalytic residue [active] 1155777007519 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1155777007520 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1155777007521 tetramer interface [polypeptide binding]; other site 1155777007522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777007523 catalytic residue [active] 1155777007524 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1155777007525 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1155777007526 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1155777007527 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1155777007528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777007529 ATP binding site [chemical binding]; other site 1155777007530 putative Mg++ binding site [ion binding]; other site 1155777007531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777007532 nucleotide binding region [chemical binding]; other site 1155777007533 ATP-binding site [chemical binding]; other site 1155777007534 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1155777007535 Anti-repressor SinI; Region: SinI; pfam08671 1155777007536 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155777007537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777007538 non-specific DNA binding site [nucleotide binding]; other site 1155777007539 salt bridge; other site 1155777007540 sequence-specific DNA binding site [nucleotide binding]; other site 1155777007541 Anti-repressor SinI; Region: SinI; pfam08671 1155777007542 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1155777007543 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1155777007544 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155777007545 Catalytic site [active] 1155777007546 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1155777007547 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1155777007548 YqzE-like protein; Region: YqzE; pfam14038 1155777007549 ComG operon protein 7; Region: ComGG; pfam14173 1155777007550 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1155777007551 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1155777007552 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1155777007553 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1155777007554 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1155777007555 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1155777007556 Type II/IV secretion system protein; Region: T2SE; pfam00437 1155777007557 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1155777007558 Walker A motif; other site 1155777007559 ATP binding site [chemical binding]; other site 1155777007560 Walker B motif; other site 1155777007561 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1155777007562 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1155777007563 Cl binding site [ion binding]; other site 1155777007564 oligomer interface [polypeptide binding]; other site 1155777007565 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1155777007566 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155777007567 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155777007568 Transporter associated domain; Region: CorC_HlyC; smart01091 1155777007569 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1155777007570 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155777007571 ArsC family; Region: ArsC; pfam03960 1155777007572 putative catalytic residues [active] 1155777007573 thiol/disulfide switch; other site 1155777007574 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1155777007575 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155777007576 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1155777007577 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1155777007578 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1155777007579 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1155777007580 putative active site [active] 1155777007581 Zn binding site [ion binding]; other site 1155777007582 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1155777007583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155777007584 nucleotide binding site [chemical binding]; other site 1155777007585 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1155777007586 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1155777007587 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1155777007588 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1155777007589 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1155777007590 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1155777007591 YceG-like family; Region: YceG; pfam02618 1155777007592 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1155777007593 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1155777007594 Walker A/P-loop; other site 1155777007595 ATP binding site [chemical binding]; other site 1155777007596 Q-loop/lid; other site 1155777007597 ABC transporter signature motif; other site 1155777007598 Walker B; other site 1155777007599 D-loop; other site 1155777007600 H-loop/switch region; other site 1155777007601 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1155777007602 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1155777007603 Walker A/P-loop; other site 1155777007604 ATP binding site [chemical binding]; other site 1155777007605 Q-loop/lid; other site 1155777007606 ABC transporter signature motif; other site 1155777007607 Walker B; other site 1155777007608 D-loop; other site 1155777007609 H-loop/switch region; other site 1155777007610 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1155777007611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777007612 dimer interface [polypeptide binding]; other site 1155777007613 conserved gate region; other site 1155777007614 ABC-ATPase subunit interface; other site 1155777007615 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1155777007616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777007617 dimer interface [polypeptide binding]; other site 1155777007618 conserved gate region; other site 1155777007619 putative PBP binding loops; other site 1155777007620 ABC-ATPase subunit interface; other site 1155777007621 PBP superfamily domain; Region: PBP_like_2; cl17296 1155777007622 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1155777007623 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155777007624 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155777007625 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155777007626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777007627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777007628 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1155777007629 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1155777007630 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1155777007631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1155777007632 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1155777007633 Lysin motif; Region: LysM; smart00257 1155777007634 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1155777007635 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1155777007636 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1155777007637 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1155777007638 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155777007639 metal binding site 2 [ion binding]; metal-binding site 1155777007640 putative DNA binding helix; other site 1155777007641 metal binding site 1 [ion binding]; metal-binding site 1155777007642 dimer interface [polypeptide binding]; other site 1155777007643 structural Zn2+ binding site [ion binding]; other site 1155777007644 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155777007645 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777007646 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155777007647 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1155777007648 endonuclease IV; Provisional; Region: PRK01060 1155777007649 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1155777007650 AP (apurinic/apyrimidinic) site pocket; other site 1155777007651 DNA interaction; other site 1155777007652 Metal-binding active site; metal-binding site 1155777007653 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155777007654 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155777007655 ATP binding site [chemical binding]; other site 1155777007656 Mg++ binding site [ion binding]; other site 1155777007657 motif III; other site 1155777007658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777007659 nucleotide binding region [chemical binding]; other site 1155777007660 ATP-binding site [chemical binding]; other site 1155777007661 YqfQ-like protein; Region: YqfQ; pfam14181 1155777007662 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1155777007663 LytB protein; Region: LYTB; pfam02401 1155777007664 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1155777007665 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1155777007666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1155777007667 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1155777007668 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1155777007669 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1155777007670 Family of unknown function (DUF633); Region: DUF633; pfam04816 1155777007671 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1155777007672 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1155777007673 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1155777007674 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1155777007675 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1155777007676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777007677 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155777007678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777007679 DNA binding residues [nucleotide binding] 1155777007680 DNA primase; Validated; Region: dnaG; PRK05667 1155777007681 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1155777007682 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1155777007683 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1155777007684 active site 1155777007685 metal binding site [ion binding]; metal-binding site 1155777007686 interdomain interaction site; other site 1155777007687 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1155777007688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1155777007689 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1155777007690 HTH domain; Region: HTH_11; pfam08279 1155777007691 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1155777007692 FOG: CBS domain [General function prediction only]; Region: COG0517 1155777007693 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1155777007694 DALR anticodon binding domain; Region: DALR_1; pfam05746 1155777007695 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1155777007696 dimer interface [polypeptide binding]; other site 1155777007697 motif 1; other site 1155777007698 active site 1155777007699 motif 2; other site 1155777007700 motif 3; other site 1155777007701 Recombination protein O N terminal; Region: RecO_N; pfam11967 1155777007702 DNA repair protein RecO; Region: reco; TIGR00613 1155777007703 Recombination protein O C terminal; Region: RecO_C; pfam02565 1155777007704 GTPase Era; Reviewed; Region: era; PRK00089 1155777007705 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1155777007706 G1 box; other site 1155777007707 GTP/Mg2+ binding site [chemical binding]; other site 1155777007708 Switch I region; other site 1155777007709 G2 box; other site 1155777007710 Switch II region; other site 1155777007711 G3 box; other site 1155777007712 G4 box; other site 1155777007713 G5 box; other site 1155777007714 KH domain; Region: KH_2; pfam07650 1155777007715 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1155777007716 active site 1155777007717 catalytic motif [active] 1155777007718 Zn binding site [ion binding]; other site 1155777007719 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1155777007720 metal-binding heat shock protein; Provisional; Region: PRK00016 1155777007721 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1155777007722 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1155777007723 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155777007724 Zn2+ binding site [ion binding]; other site 1155777007725 Mg2+ binding site [ion binding]; other site 1155777007726 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1155777007727 PhoH-like protein; Region: PhoH; pfam02562 1155777007728 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1155777007729 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1155777007730 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1155777007731 hypothetical protein; Provisional; Region: PRK13665 1155777007732 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1155777007733 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1155777007734 dimer interface [polypeptide binding]; other site 1155777007735 active site residues [active] 1155777007736 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1155777007737 Yqey-like protein; Region: YqeY; pfam09424 1155777007738 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1155777007739 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1155777007740 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1155777007741 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1155777007742 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1155777007743 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1155777007744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777007745 FeS/SAM binding site; other site 1155777007746 TRAM domain; Region: TRAM; cl01282 1155777007747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1155777007748 RNA methyltransferase, RsmE family; Region: TIGR00046 1155777007749 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1155777007750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777007751 S-adenosylmethionine binding site [chemical binding]; other site 1155777007752 chaperone protein DnaJ; Provisional; Region: PRK14280 1155777007753 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1155777007754 HSP70 interaction site [polypeptide binding]; other site 1155777007755 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1155777007756 substrate binding site [polypeptide binding]; other site 1155777007757 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1155777007758 Zn binding sites [ion binding]; other site 1155777007759 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1155777007760 dimer interface [polypeptide binding]; other site 1155777007761 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1155777007762 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1155777007763 nucleotide binding site [chemical binding]; other site 1155777007764 NEF interaction site [polypeptide binding]; other site 1155777007765 SBD interface [polypeptide binding]; other site 1155777007766 GrpE; Region: GrpE; pfam01025 1155777007767 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1155777007768 dimer interface [polypeptide binding]; other site 1155777007769 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1155777007770 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1155777007771 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1155777007772 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1155777007773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777007774 FeS/SAM binding site; other site 1155777007775 HemN C-terminal domain; Region: HemN_C; pfam06969 1155777007776 GTP-binding protein LepA; Provisional; Region: PRK05433 1155777007777 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1155777007778 G1 box; other site 1155777007779 putative GEF interaction site [polypeptide binding]; other site 1155777007780 GTP/Mg2+ binding site [chemical binding]; other site 1155777007781 Switch I region; other site 1155777007782 G2 box; other site 1155777007783 G3 box; other site 1155777007784 Switch II region; other site 1155777007785 G4 box; other site 1155777007786 G5 box; other site 1155777007787 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1155777007788 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1155777007789 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1155777007790 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1155777007791 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1155777007792 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1155777007793 germination protease; Provisional; Region: PRK02858 1155777007794 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1155777007795 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1155777007796 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1155777007797 YqzM-like protein; Region: YqzM; pfam14141 1155777007798 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1155777007799 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1155777007800 Competence protein; Region: Competence; pfam03772 1155777007801 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155777007802 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1155777007803 catalytic motif [active] 1155777007804 Zn binding site [ion binding]; other site 1155777007805 SLBB domain; Region: SLBB; pfam10531 1155777007806 comEA protein; Region: comE; TIGR01259 1155777007807 Helix-hairpin-helix motif; Region: HHH; pfam00633 1155777007808 late competence protein ComER; Validated; Region: PRK07680 1155777007809 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1155777007810 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155777007811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777007812 S-adenosylmethionine binding site [chemical binding]; other site 1155777007813 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1155777007814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155777007815 Zn2+ binding site [ion binding]; other site 1155777007816 Mg2+ binding site [ion binding]; other site 1155777007817 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1155777007818 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1155777007819 active site 1155777007820 (T/H)XGH motif; other site 1155777007821 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1155777007822 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1155777007823 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1155777007824 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1155777007825 shikimate binding site; other site 1155777007826 NAD(P) binding site [chemical binding]; other site 1155777007827 GTPase YqeH; Provisional; Region: PRK13796 1155777007828 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1155777007829 GTP/Mg2+ binding site [chemical binding]; other site 1155777007830 G4 box; other site 1155777007831 G5 box; other site 1155777007832 G1 box; other site 1155777007833 Switch I region; other site 1155777007834 G2 box; other site 1155777007835 G3 box; other site 1155777007836 Switch II region; other site 1155777007837 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1155777007838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777007839 active site 1155777007840 motif I; other site 1155777007841 motif II; other site 1155777007842 Sporulation inhibitor A; Region: Sda; pfam08970 1155777007843 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1155777007844 active site 1155777007845 catalytic triad [active] 1155777007846 oxyanion hole [active] 1155777007847 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1155777007848 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1155777007849 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1155777007850 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155777007851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777007852 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155777007853 putative substrate translocation pore; other site 1155777007854 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1155777007855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155777007856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777007857 DNA binding residues [nucleotide binding] 1155777007858 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1155777007859 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155777007860 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1155777007861 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155777007862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777007863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1155777007864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777007865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777007866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777007867 dimerization interface [polypeptide binding]; other site 1155777007868 putative transporter; Provisional; Region: PRK11021 1155777007869 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1155777007870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777007871 HAMP domain; Region: HAMP; pfam00672 1155777007872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777007873 dimer interface [polypeptide binding]; other site 1155777007874 phosphorylation site [posttranslational modification] 1155777007875 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155777007876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777007877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777007878 active site 1155777007879 phosphorylation site [posttranslational modification] 1155777007880 intermolecular recognition site; other site 1155777007881 dimerization interface [polypeptide binding]; other site 1155777007882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777007883 DNA binding site [nucleotide binding] 1155777007884 Predicted membrane protein [Function unknown]; Region: COG2311 1155777007885 Protein of unknown function (DUF418); Region: DUF418; cl12135 1155777007886 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1155777007887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777007888 Coenzyme A binding pocket [chemical binding]; other site 1155777007889 hypothetical protein; Validated; Region: PRK06217 1155777007890 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1155777007891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777007892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777007893 putative substrate translocation pore; other site 1155777007894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777007895 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1155777007896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777007897 Coenzyme A binding pocket [chemical binding]; other site 1155777007898 DinB family; Region: DinB; pfam05163 1155777007899 DinB superfamily; Region: DinB_2; pfam12867 1155777007900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1155777007901 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155777007902 active site 1155777007903 motif I; other site 1155777007904 motif II; other site 1155777007905 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155777007906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777007907 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155777007908 active site 1155777007909 motif I; other site 1155777007910 motif II; other site 1155777007911 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155777007912 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155777007913 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155777007914 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155777007915 putative active site [active] 1155777007916 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1155777007917 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1155777007918 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1155777007919 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155777007920 active site 1155777007921 P-loop; other site 1155777007922 phosphorylation site [posttranslational modification] 1155777007923 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155777007924 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155777007925 active site 1155777007926 phosphorylation site [posttranslational modification] 1155777007927 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155777007928 HTH domain; Region: HTH_11; pfam08279 1155777007929 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155777007930 PRD domain; Region: PRD; pfam00874 1155777007931 PRD domain; Region: PRD; pfam00874 1155777007932 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155777007933 active site 1155777007934 P-loop; other site 1155777007935 phosphorylation site [posttranslational modification] 1155777007936 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155777007937 active site 1155777007938 phosphorylation site [posttranslational modification] 1155777007939 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155777007940 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1155777007941 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1155777007942 putative deacylase active site [active] 1155777007943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777007944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777007945 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1155777007946 putative dimerization interface [polypeptide binding]; other site 1155777007947 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777007948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777007949 putative substrate translocation pore; other site 1155777007950 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1155777007951 Cytochrome P450; Region: p450; pfam00067 1155777007952 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1155777007953 Flavodoxin; Region: Flavodoxin_1; pfam00258 1155777007954 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1155777007955 FAD binding pocket [chemical binding]; other site 1155777007956 FAD binding motif [chemical binding]; other site 1155777007957 catalytic residues [active] 1155777007958 NAD binding pocket [chemical binding]; other site 1155777007959 phosphate binding motif [ion binding]; other site 1155777007960 beta-alpha-beta structure motif; other site 1155777007961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777007962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777007963 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1155777007964 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1155777007965 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1155777007966 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1155777007967 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1155777007968 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1155777007969 catalytic loop [active] 1155777007970 iron binding site [ion binding]; other site 1155777007971 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1155777007972 4Fe-4S binding domain; Region: Fer4; pfam00037 1155777007973 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1155777007974 [4Fe-4S] binding site [ion binding]; other site 1155777007975 molybdopterin cofactor binding site; other site 1155777007976 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1155777007977 molybdopterin cofactor binding site; other site 1155777007978 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1155777007979 YrhC-like protein; Region: YrhC; pfam14143 1155777007980 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1155777007981 homodimer interface [polypeptide binding]; other site 1155777007982 substrate-cofactor binding pocket; other site 1155777007983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777007984 catalytic residue [active] 1155777007985 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1155777007986 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155777007987 dimer interface [polypeptide binding]; other site 1155777007988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777007989 catalytic residue [active] 1155777007990 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1155777007991 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1155777007992 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1155777007993 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1155777007994 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1155777007995 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155777007996 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155777007997 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155777007998 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1155777007999 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1155777008000 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1155777008001 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1155777008002 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155777008003 substrate binding site [chemical binding]; other site 1155777008004 amidase catalytic site [active] 1155777008005 Zn binding residues [ion binding]; other site 1155777008006 Bacterial SH3 domain; Region: SH3_3; pfam08239 1155777008007 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1155777008008 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1155777008009 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1155777008010 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1155777008011 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1155777008012 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155777008013 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1155777008014 Phage tail protein; Region: Sipho_tail; pfam05709 1155777008015 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1155777008016 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155777008017 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155777008018 catalytic residue [active] 1155777008019 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1155777008020 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1155777008021 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1155777008022 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1155777008023 oligomerization interface [polypeptide binding]; other site 1155777008024 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1155777008025 Phage capsid family; Region: Phage_capsid; pfam05065 1155777008026 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1155777008027 Phage-related protein [Function unknown]; Region: COG4695 1155777008028 Phage portal protein; Region: Phage_portal; pfam04860 1155777008029 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1155777008030 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1155777008031 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1155777008032 HNH endonuclease; Region: HNH; pfam01844 1155777008033 active site 1155777008034 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1155777008035 Int/Topo IB signature motif; other site 1155777008036 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1155777008037 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1155777008038 active site 1155777008039 homodimer interface [polypeptide binding]; other site 1155777008040 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1155777008041 dUTPase; Region: dUTPase_2; pfam08761 1155777008042 Helix-turn-helix domain; Region: HTH_17; cl17695 1155777008043 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1155777008044 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1155777008045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1155777008046 Walker A motif; other site 1155777008047 ATP binding site [chemical binding]; other site 1155777008048 Walker B motif; other site 1155777008049 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1155777008050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777008051 non-specific DNA binding site [nucleotide binding]; other site 1155777008052 salt bridge; other site 1155777008053 sequence-specific DNA binding site [nucleotide binding]; other site 1155777008054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777008055 non-specific DNA binding site [nucleotide binding]; other site 1155777008056 salt bridge; other site 1155777008057 sequence-specific DNA binding site [nucleotide binding]; other site 1155777008058 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155777008059 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155777008060 Int/Topo IB signature motif; other site 1155777008061 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1155777008062 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1155777008063 ATP-binding site [chemical binding]; other site 1155777008064 Sugar specificity; other site 1155777008065 Pyrimidine base specificity; other site 1155777008066 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1155777008067 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1155777008068 Peptidase family U32; Region: Peptidase_U32; pfam01136 1155777008069 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1155777008070 Peptidase family U32; Region: Peptidase_U32; pfam01136 1155777008071 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1155777008072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777008073 S-adenosylmethionine binding site [chemical binding]; other site 1155777008074 conserved hypothetical protein, YceG family; Region: TIGR00247 1155777008075 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1155777008076 dimerization interface [polypeptide binding]; other site 1155777008077 hypothetical protein; Provisional; Region: PRK13678 1155777008078 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1155777008079 hypothetical protein; Provisional; Region: PRK05473 1155777008080 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1155777008081 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1155777008082 motif 1; other site 1155777008083 active site 1155777008084 motif 2; other site 1155777008085 motif 3; other site 1155777008086 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1155777008087 DHHA1 domain; Region: DHHA1; pfam02272 1155777008088 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155777008089 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155777008090 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155777008091 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155777008092 Walker A/P-loop; other site 1155777008093 ATP binding site [chemical binding]; other site 1155777008094 Q-loop/lid; other site 1155777008095 ABC transporter signature motif; other site 1155777008096 Walker B; other site 1155777008097 D-loop; other site 1155777008098 H-loop/switch region; other site 1155777008099 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1155777008100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155777008101 substrate binding pocket [chemical binding]; other site 1155777008102 membrane-bound complex binding site; other site 1155777008103 hinge residues; other site 1155777008104 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155777008105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777008106 dimer interface [polypeptide binding]; other site 1155777008107 conserved gate region; other site 1155777008108 putative PBP binding loops; other site 1155777008109 ABC-ATPase subunit interface; other site 1155777008110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777008111 dimer interface [polypeptide binding]; other site 1155777008112 conserved gate region; other site 1155777008113 putative PBP binding loops; other site 1155777008114 ABC-ATPase subunit interface; other site 1155777008115 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1155777008116 PRC-barrel domain; Region: PRC; pfam05239 1155777008117 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1155777008118 AAA domain; Region: AAA_30; pfam13604 1155777008119 Family description; Region: UvrD_C_2; pfam13538 1155777008120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777008121 binding surface 1155777008122 TPR repeat; Region: TPR_11; pfam13414 1155777008123 TPR motif; other site 1155777008124 TPR repeat; Region: TPR_11; pfam13414 1155777008125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777008126 binding surface 1155777008127 TPR motif; other site 1155777008128 TPR repeat; Region: TPR_11; pfam13414 1155777008129 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1155777008130 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1155777008131 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1155777008132 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155777008133 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155777008134 catalytic residue [active] 1155777008135 Predicted transcriptional regulator [Transcription]; Region: COG1959 1155777008136 Transcriptional regulator; Region: Rrf2; pfam02082 1155777008137 recombination factor protein RarA; Reviewed; Region: PRK13342 1155777008138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777008139 Walker A motif; other site 1155777008140 ATP binding site [chemical binding]; other site 1155777008141 Walker B motif; other site 1155777008142 arginine finger; other site 1155777008143 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1155777008144 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1155777008145 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1155777008146 putative ATP binding site [chemical binding]; other site 1155777008147 putative substrate interface [chemical binding]; other site 1155777008148 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1155777008149 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1155777008150 dimer interface [polypeptide binding]; other site 1155777008151 anticodon binding site; other site 1155777008152 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1155777008153 homodimer interface [polypeptide binding]; other site 1155777008154 motif 1; other site 1155777008155 active site 1155777008156 motif 2; other site 1155777008157 GAD domain; Region: GAD; pfam02938 1155777008158 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1155777008159 active site 1155777008160 motif 3; other site 1155777008161 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1155777008162 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1155777008163 dimer interface [polypeptide binding]; other site 1155777008164 motif 1; other site 1155777008165 active site 1155777008166 motif 2; other site 1155777008167 motif 3; other site 1155777008168 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1155777008169 anticodon binding site; other site 1155777008170 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1155777008171 Bacterial SH3 domain; Region: SH3_3; pfam08239 1155777008172 Bacterial SH3 domain; Region: SH3_3; pfam08239 1155777008173 Bacterial SH3 domain; Region: SH3_3; pfam08239 1155777008174 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1155777008175 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1155777008176 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1155777008177 active site 1155777008178 metal binding site [ion binding]; metal-binding site 1155777008179 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1155777008180 putative active site [active] 1155777008181 dimerization interface [polypeptide binding]; other site 1155777008182 putative tRNAtyr binding site [nucleotide binding]; other site 1155777008183 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1155777008184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155777008185 Zn2+ binding site [ion binding]; other site 1155777008186 Mg2+ binding site [ion binding]; other site 1155777008187 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155777008188 synthetase active site [active] 1155777008189 NTP binding site [chemical binding]; other site 1155777008190 metal binding site [ion binding]; metal-binding site 1155777008191 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1155777008192 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1155777008193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777008194 active site 1155777008195 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1155777008196 DHH family; Region: DHH; pfam01368 1155777008197 DHHA1 domain; Region: DHHA1; pfam02272 1155777008198 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1155777008199 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1155777008200 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1155777008201 TrkA-C domain; Region: TrkA_C; pfam02080 1155777008202 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1155777008203 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1155777008204 Protein export membrane protein; Region: SecD_SecF; pfam02355 1155777008205 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1155777008206 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1155777008207 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155777008208 Predicted membrane protein [Function unknown]; Region: COG2323 1155777008209 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1155777008210 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1155777008211 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1155777008212 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1155777008213 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1155777008214 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1155777008215 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1155777008216 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1155777008217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777008218 Walker A motif; other site 1155777008219 ATP binding site [chemical binding]; other site 1155777008220 Walker B motif; other site 1155777008221 arginine finger; other site 1155777008222 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1155777008223 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1155777008224 RuvA N terminal domain; Region: RuvA_N; pfam01330 1155777008225 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1155777008226 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1155777008227 BofC C-terminal domain; Region: BofC_C; pfam08955 1155777008228 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1155777008229 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155777008230 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777008231 quinolinate synthetase; Provisional; Region: PRK09375 1155777008232 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1155777008233 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1155777008234 dimerization interface [polypeptide binding]; other site 1155777008235 active site 1155777008236 L-aspartate oxidase; Provisional; Region: PRK08071 1155777008237 L-aspartate oxidase; Provisional; Region: PRK06175 1155777008238 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1155777008239 cysteine desulfurase; Provisional; Region: PRK02948 1155777008240 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155777008241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155777008242 catalytic residue [active] 1155777008243 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1155777008244 HTH domain; Region: HTH_11; pfam08279 1155777008245 3H domain; Region: 3H; pfam02829 1155777008246 prephenate dehydratase; Provisional; Region: PRK11898 1155777008247 Prephenate dehydratase; Region: PDT; pfam00800 1155777008248 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1155777008249 putative L-Phe binding site [chemical binding]; other site 1155777008250 hypothetical protein; Provisional; Region: PRK04435 1155777008251 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1155777008252 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1155777008253 GTP1/OBG; Region: GTP1_OBG; pfam01018 1155777008254 Obg GTPase; Region: Obg; cd01898 1155777008255 G1 box; other site 1155777008256 GTP/Mg2+ binding site [chemical binding]; other site 1155777008257 Switch I region; other site 1155777008258 G2 box; other site 1155777008259 G3 box; other site 1155777008260 Switch II region; other site 1155777008261 G4 box; other site 1155777008262 G5 box; other site 1155777008263 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1155777008264 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1155777008265 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1155777008266 hypothetical protein; Provisional; Region: PRK14553 1155777008267 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1155777008268 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1155777008269 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1155777008270 Peptidase family M50; Region: Peptidase_M50; pfam02163 1155777008271 active site 1155777008272 putative substrate binding region [chemical binding]; other site 1155777008273 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155777008274 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155777008275 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1155777008276 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1155777008277 Switch I; other site 1155777008278 Switch II; other site 1155777008279 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1155777008280 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1155777008281 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1155777008282 rod shape-determining protein MreC; Region: mreC; TIGR00219 1155777008283 rod shape-determining protein MreC; Region: MreC; pfam04085 1155777008284 rod shape-determining protein MreB; Provisional; Region: PRK13927 1155777008285 MreB and similar proteins; Region: MreB_like; cd10225 1155777008286 nucleotide binding site [chemical binding]; other site 1155777008287 Mg binding site [ion binding]; other site 1155777008288 putative protofilament interaction site [polypeptide binding]; other site 1155777008289 RodZ interaction site [polypeptide binding]; other site 1155777008290 hypothetical protein; Reviewed; Region: PRK00024 1155777008291 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1155777008292 MPN+ (JAMM) motif; other site 1155777008293 Zinc-binding site [ion binding]; other site 1155777008294 Maf-like protein; Region: Maf; pfam02545 1155777008295 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1155777008296 active site 1155777008297 dimer interface [polypeptide binding]; other site 1155777008298 Sporulation related domain; Region: SPOR; pfam05036 1155777008299 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1155777008300 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1155777008301 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1155777008302 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1155777008303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155777008304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155777008305 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1155777008306 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155777008307 active site 1155777008308 HIGH motif; other site 1155777008309 nucleotide binding site [chemical binding]; other site 1155777008310 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155777008311 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1155777008312 active site 1155777008313 KMSKS motif; other site 1155777008314 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1155777008315 tRNA binding surface [nucleotide binding]; other site 1155777008316 anticodon binding site; other site 1155777008317 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1155777008318 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1155777008319 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1155777008320 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1155777008321 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155777008322 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1155777008323 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777008324 inhibitor-cofactor binding pocket; inhibition site 1155777008325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777008326 catalytic residue [active] 1155777008327 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1155777008328 dimer interface [polypeptide binding]; other site 1155777008329 active site 1155777008330 Schiff base residues; other site 1155777008331 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1155777008332 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1155777008333 active site 1155777008334 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1155777008335 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1155777008336 domain interfaces; other site 1155777008337 active site 1155777008338 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1155777008339 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1155777008340 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1155777008341 tRNA; other site 1155777008342 putative tRNA binding site [nucleotide binding]; other site 1155777008343 putative NADP binding site [chemical binding]; other site 1155777008344 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1155777008345 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1155777008346 G1 box; other site 1155777008347 GTP/Mg2+ binding site [chemical binding]; other site 1155777008348 Switch I region; other site 1155777008349 G2 box; other site 1155777008350 G3 box; other site 1155777008351 Switch II region; other site 1155777008352 G4 box; other site 1155777008353 G5 box; other site 1155777008354 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1155777008355 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1155777008356 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1155777008357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777008358 Walker A motif; other site 1155777008359 ATP binding site [chemical binding]; other site 1155777008360 Walker B motif; other site 1155777008361 arginine finger; other site 1155777008362 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1155777008363 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1155777008364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777008365 Walker A motif; other site 1155777008366 ATP binding site [chemical binding]; other site 1155777008367 Walker B motif; other site 1155777008368 arginine finger; other site 1155777008369 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1155777008370 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1155777008371 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1155777008372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777008373 Walker A motif; other site 1155777008374 ATP binding site [chemical binding]; other site 1155777008375 Walker B motif; other site 1155777008376 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155777008377 trigger factor; Provisional; Region: tig; PRK01490 1155777008378 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1155777008379 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1155777008380 TPR repeat; Region: TPR_11; pfam13414 1155777008381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777008382 binding surface 1155777008383 TPR motif; other site 1155777008384 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1155777008385 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1155777008386 substrate binding site [chemical binding]; other site 1155777008387 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1155777008388 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1155777008389 substrate binding site [chemical binding]; other site 1155777008390 ligand binding site [chemical binding]; other site 1155777008391 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1155777008392 tartrate dehydrogenase; Region: TTC; TIGR02089 1155777008393 2-isopropylmalate synthase; Validated; Region: PRK00915 1155777008394 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1155777008395 active site 1155777008396 catalytic residues [active] 1155777008397 metal binding site [ion binding]; metal-binding site 1155777008398 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1155777008399 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1155777008400 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1155777008401 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1155777008402 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1155777008403 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1155777008404 putative valine binding site [chemical binding]; other site 1155777008405 dimer interface [polypeptide binding]; other site 1155777008406 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1155777008407 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1155777008408 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1155777008409 PYR/PP interface [polypeptide binding]; other site 1155777008410 dimer interface [polypeptide binding]; other site 1155777008411 TPP binding site [chemical binding]; other site 1155777008412 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155777008413 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1155777008414 TPP-binding site [chemical binding]; other site 1155777008415 dimer interface [polypeptide binding]; other site 1155777008416 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1155777008417 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1155777008418 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1155777008419 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1155777008420 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1155777008421 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1155777008422 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1155777008423 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1155777008424 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1155777008425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777008426 ATP binding site [chemical binding]; other site 1155777008427 putative Mg++ binding site [ion binding]; other site 1155777008428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777008429 nucleotide binding region [chemical binding]; other site 1155777008430 ATP-binding site [chemical binding]; other site 1155777008431 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1155777008432 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155777008433 active site 1155777008434 metal binding site [ion binding]; metal-binding site 1155777008435 homotetramer interface [polypeptide binding]; other site 1155777008436 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1155777008437 active site 1155777008438 dimerization interface [polypeptide binding]; other site 1155777008439 ribonuclease PH; Reviewed; Region: rph; PRK00173 1155777008440 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1155777008441 hexamer interface [polypeptide binding]; other site 1155777008442 active site 1155777008443 Sporulation and spore germination; Region: Germane; pfam10646 1155777008444 Spore germination protein [General function prediction only]; Region: COG5401 1155777008445 Sporulation and spore germination; Region: Germane; pfam10646 1155777008446 glutamate racemase; Provisional; Region: PRK00865 1155777008447 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777008448 MarR family; Region: MarR; pfam01047 1155777008449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777008450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777008451 DNA binding residues [nucleotide binding] 1155777008452 dimerization interface [polypeptide binding]; other site 1155777008453 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155777008454 active site 1155777008455 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1155777008456 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1155777008457 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1155777008458 L-aspartate oxidase; Provisional; Region: PRK06175 1155777008459 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1155777008460 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1155777008461 putative Iron-sulfur protein interface [polypeptide binding]; other site 1155777008462 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1155777008463 proximal heme binding site [chemical binding]; other site 1155777008464 distal heme binding site [chemical binding]; other site 1155777008465 putative dimer interface [polypeptide binding]; other site 1155777008466 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1155777008467 aspartate kinase; Reviewed; Region: PRK06635 1155777008468 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1155777008469 putative nucleotide binding site [chemical binding]; other site 1155777008470 putative catalytic residues [active] 1155777008471 putative Mg ion binding site [ion binding]; other site 1155777008472 putative aspartate binding site [chemical binding]; other site 1155777008473 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1155777008474 putative allosteric regulatory site; other site 1155777008475 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1155777008476 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1155777008477 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1155777008478 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1155777008479 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1155777008480 GIY-YIG motif/motif A; other site 1155777008481 active site 1155777008482 catalytic site [active] 1155777008483 putative DNA binding site [nucleotide binding]; other site 1155777008484 metal binding site [ion binding]; metal-binding site 1155777008485 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1155777008486 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155777008487 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155777008488 catalytic residues [active] 1155777008489 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1155777008490 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1155777008491 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1155777008492 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1155777008493 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1155777008494 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1155777008495 Ligand binding site [chemical binding]; other site 1155777008496 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1155777008497 enoyl-CoA hydratase; Provisional; Region: PRK07658 1155777008498 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155777008499 substrate binding site [chemical binding]; other site 1155777008500 oxyanion hole (OAH) forming residues; other site 1155777008501 trimer interface [polypeptide binding]; other site 1155777008502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777008503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777008504 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1155777008505 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1155777008506 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1155777008507 acyl-activating enzyme (AAE) consensus motif; other site 1155777008508 putative AMP binding site [chemical binding]; other site 1155777008509 putative active site [active] 1155777008510 putative CoA binding site [chemical binding]; other site 1155777008511 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1155777008512 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1155777008513 Predicted membrane protein [Function unknown]; Region: COG3766 1155777008514 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1155777008515 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1155777008516 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1155777008517 MutS domain III; Region: MutS_III; pfam05192 1155777008518 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1155777008519 Walker A/P-loop; other site 1155777008520 ATP binding site [chemical binding]; other site 1155777008521 Q-loop/lid; other site 1155777008522 ABC transporter signature motif; other site 1155777008523 Walker B; other site 1155777008524 D-loop; other site 1155777008525 H-loop/switch region; other site 1155777008526 Smr domain; Region: Smr; pfam01713 1155777008527 hypothetical protein; Provisional; Region: PRK08609 1155777008528 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1155777008529 active site 1155777008530 primer binding site [nucleotide binding]; other site 1155777008531 NTP binding site [chemical binding]; other site 1155777008532 metal binding triad [ion binding]; metal-binding site 1155777008533 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1155777008534 active site 1155777008535 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1155777008536 Colicin V production protein; Region: Colicin_V; pfam02674 1155777008537 cell division protein ZapA; Provisional; Region: PRK14126 1155777008538 ribonuclease HIII; Provisional; Region: PRK00996 1155777008539 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1155777008540 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1155777008541 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155777008542 active site 1155777008543 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1155777008544 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1155777008545 putative tRNA-binding site [nucleotide binding]; other site 1155777008546 B3/4 domain; Region: B3_4; pfam03483 1155777008547 tRNA synthetase B5 domain; Region: B5; smart00874 1155777008548 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1155777008549 dimer interface [polypeptide binding]; other site 1155777008550 motif 1; other site 1155777008551 motif 3; other site 1155777008552 motif 2; other site 1155777008553 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1155777008554 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1155777008555 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1155777008556 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1155777008557 dimer interface [polypeptide binding]; other site 1155777008558 motif 1; other site 1155777008559 active site 1155777008560 motif 2; other site 1155777008561 motif 3; other site 1155777008562 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1155777008563 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1155777008564 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1155777008565 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1155777008566 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1155777008567 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1155777008568 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1155777008569 FAD binding domain; Region: FAD_binding_4; pfam01565 1155777008570 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1155777008571 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1155777008572 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1155777008573 Cysteine-rich domain; Region: CCG; pfam02754 1155777008574 Cysteine-rich domain; Region: CCG; pfam02754 1155777008575 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1155777008576 Carbon starvation protein CstA; Region: CstA; pfam02554 1155777008577 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1155777008578 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1155777008579 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1155777008580 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155777008581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777008582 putative PBP binding loops; other site 1155777008583 dimer interface [polypeptide binding]; other site 1155777008584 ABC-ATPase subunit interface; other site 1155777008585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777008586 dimer interface [polypeptide binding]; other site 1155777008587 conserved gate region; other site 1155777008588 putative PBP binding loops; other site 1155777008589 ABC-ATPase subunit interface; other site 1155777008590 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155777008591 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155777008592 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1155777008593 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1155777008594 active site 1155777008595 metal binding site [ion binding]; metal-binding site 1155777008596 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1155777008597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777008598 active site 1155777008599 motif I; other site 1155777008600 motif II; other site 1155777008601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777008602 motif II; other site 1155777008603 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1155777008604 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1155777008605 intersubunit interface [polypeptide binding]; other site 1155777008606 active site 1155777008607 Zn2+ binding site [ion binding]; other site 1155777008608 ribulokinase; Provisional; Region: PRK04123 1155777008609 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1155777008610 N- and C-terminal domain interface [polypeptide binding]; other site 1155777008611 active site 1155777008612 MgATP binding site [chemical binding]; other site 1155777008613 catalytic site [active] 1155777008614 metal binding site [ion binding]; metal-binding site 1155777008615 carbohydrate binding site [chemical binding]; other site 1155777008616 homodimer interface [polypeptide binding]; other site 1155777008617 L-arabinose isomerase; Provisional; Region: PRK02929 1155777008618 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1155777008619 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1155777008620 trimer interface [polypeptide binding]; other site 1155777008621 putative substrate binding site [chemical binding]; other site 1155777008622 putative metal binding site [ion binding]; other site 1155777008623 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1155777008624 substrate binding site [chemical binding]; other site 1155777008625 active site 1155777008626 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155777008627 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1155777008628 oligomer interface [polypeptide binding]; other site 1155777008629 active site 1155777008630 metal binding site [ion binding]; metal-binding site 1155777008631 Predicted integral membrane protein [Function unknown]; Region: COG5615 1155777008632 Predicted membrane protein [Function unknown]; Region: COG3326 1155777008633 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1155777008634 23S rRNA binding site [nucleotide binding]; other site 1155777008635 L21 binding site [polypeptide binding]; other site 1155777008636 L13 binding site [polypeptide binding]; other site 1155777008637 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1155777008638 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1155777008639 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1155777008640 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1155777008641 antiholin-like protein LrgB; Provisional; Region: PRK04288 1155777008642 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1155777008643 two-component response regulator; Provisional; Region: PRK14084 1155777008644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777008645 active site 1155777008646 phosphorylation site [posttranslational modification] 1155777008647 intermolecular recognition site; other site 1155777008648 dimerization interface [polypeptide binding]; other site 1155777008649 LytTr DNA-binding domain; Region: LytTR; smart00850 1155777008650 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1155777008651 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1155777008652 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1155777008653 Histidine kinase; Region: His_kinase; pfam06580 1155777008654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777008655 ATP binding site [chemical binding]; other site 1155777008656 Mg2+ binding site [ion binding]; other site 1155777008657 G-X-G motif; other site 1155777008658 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1155777008659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777008660 motif II; other site 1155777008661 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1155777008662 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1155777008663 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1155777008664 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1155777008665 active site 1155777008666 dimer interface [polypeptide binding]; other site 1155777008667 motif 1; other site 1155777008668 motif 2; other site 1155777008669 motif 3; other site 1155777008670 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1155777008671 anticodon binding site; other site 1155777008672 YtxC-like family; Region: YtxC; pfam08812 1155777008673 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1155777008674 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155777008675 primosomal protein DnaI; Reviewed; Region: PRK08939 1155777008676 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1155777008677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777008678 Walker A motif; other site 1155777008679 ATP binding site [chemical binding]; other site 1155777008680 Walker B motif; other site 1155777008681 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1155777008682 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1155777008683 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1155777008684 ATP cone domain; Region: ATP-cone; pfam03477 1155777008685 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1155777008686 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1155777008687 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1155777008688 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155777008689 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155777008690 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155777008691 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777008692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777008693 putative substrate translocation pore; other site 1155777008694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155777008695 active site 1155777008696 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155777008697 catalytic tetrad [active] 1155777008698 dephospho-CoA kinase; Region: TIGR00152 1155777008699 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1155777008700 CoA-binding site [chemical binding]; other site 1155777008701 ATP-binding [chemical binding]; other site 1155777008702 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1155777008703 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1155777008704 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1155777008705 DNA binding site [nucleotide binding] 1155777008706 catalytic residue [active] 1155777008707 H2TH interface [polypeptide binding]; other site 1155777008708 putative catalytic residues [active] 1155777008709 turnover-facilitating residue; other site 1155777008710 intercalation triad [nucleotide binding]; other site 1155777008711 8OG recognition residue [nucleotide binding]; other site 1155777008712 putative reading head residues; other site 1155777008713 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1155777008714 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1155777008715 DNA polymerase I; Provisional; Region: PRK05755 1155777008716 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1155777008717 active site 1155777008718 metal binding site 1 [ion binding]; metal-binding site 1155777008719 putative 5' ssDNA interaction site; other site 1155777008720 metal binding site 3; metal-binding site 1155777008721 metal binding site 2 [ion binding]; metal-binding site 1155777008722 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1155777008723 putative DNA binding site [nucleotide binding]; other site 1155777008724 putative metal binding site [ion binding]; other site 1155777008725 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1155777008726 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1155777008727 active site 1155777008728 DNA binding site [nucleotide binding] 1155777008729 catalytic site [active] 1155777008730 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1155777008731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777008732 putative active site [active] 1155777008733 heme pocket [chemical binding]; other site 1155777008734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777008735 dimer interface [polypeptide binding]; other site 1155777008736 phosphorylation site [posttranslational modification] 1155777008737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777008738 ATP binding site [chemical binding]; other site 1155777008739 Mg2+ binding site [ion binding]; other site 1155777008740 G-X-G motif; other site 1155777008741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777008742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777008743 active site 1155777008744 phosphorylation site [posttranslational modification] 1155777008745 intermolecular recognition site; other site 1155777008746 dimerization interface [polypeptide binding]; other site 1155777008747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777008748 DNA binding site [nucleotide binding] 1155777008749 malate dehydrogenase; Reviewed; Region: PRK06223 1155777008750 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1155777008751 NAD(P) binding site [chemical binding]; other site 1155777008752 dimer interface [polypeptide binding]; other site 1155777008753 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155777008754 substrate binding site [chemical binding]; other site 1155777008755 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1155777008756 isocitrate dehydrogenase; Validated; Region: PRK07362 1155777008757 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1155777008758 dimer interface [polypeptide binding]; other site 1155777008759 Citrate synthase; Region: Citrate_synt; pfam00285 1155777008760 active site 1155777008761 citrylCoA binding site [chemical binding]; other site 1155777008762 oxalacetate/citrate binding site [chemical binding]; other site 1155777008763 coenzyme A binding site [chemical binding]; other site 1155777008764 catalytic triad [active] 1155777008765 TPR repeat; Region: TPR_11; pfam13414 1155777008766 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777008767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777008768 binding surface 1155777008769 TPR motif; other site 1155777008770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777008771 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1155777008772 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1155777008773 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1155777008774 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155777008775 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1155777008776 pyruvate kinase; Provisional; Region: PRK06354 1155777008777 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1155777008778 domain interfaces; other site 1155777008779 active site 1155777008780 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1155777008781 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1155777008782 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1155777008783 active site 1155777008784 ADP/pyrophosphate binding site [chemical binding]; other site 1155777008785 dimerization interface [polypeptide binding]; other site 1155777008786 allosteric effector site; other site 1155777008787 fructose-1,6-bisphosphate binding site; other site 1155777008788 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1155777008789 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1155777008790 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1155777008791 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1155777008792 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1155777008793 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1155777008794 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1155777008795 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1155777008796 putative NAD(P) binding site [chemical binding]; other site 1155777008797 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1155777008798 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155777008799 active site 1155777008800 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1155777008801 generic binding surface I; other site 1155777008802 generic binding surface II; other site 1155777008803 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1155777008804 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1155777008805 DHH family; Region: DHH; pfam01368 1155777008806 DHHA1 domain; Region: DHHA1; pfam02272 1155777008807 YtpI-like protein; Region: YtpI; pfam14007 1155777008808 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1155777008809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1155777008810 DNA-binding site [nucleotide binding]; DNA binding site 1155777008811 DRTGG domain; Region: DRTGG; pfam07085 1155777008812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1155777008813 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1155777008814 active site 2 [active] 1155777008815 active site 1 [active] 1155777008816 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155777008817 metal-dependent hydrolase; Provisional; Region: PRK00685 1155777008818 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1155777008819 classical (c) SDRs; Region: SDR_c; cd05233 1155777008820 NAD(P) binding site [chemical binding]; other site 1155777008821 active site 1155777008822 argininosuccinate lyase; Provisional; Region: PRK00855 1155777008823 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1155777008824 active sites [active] 1155777008825 tetramer interface [polypeptide binding]; other site 1155777008826 argininosuccinate synthase; Provisional; Region: PRK13820 1155777008827 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1155777008828 ANP binding site [chemical binding]; other site 1155777008829 Substrate Binding Site II [chemical binding]; other site 1155777008830 Substrate Binding Site I [chemical binding]; other site 1155777008831 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1155777008832 MPT binding site; other site 1155777008833 trimer interface [polypeptide binding]; other site 1155777008834 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1155777008835 propionate/acetate kinase; Provisional; Region: PRK12379 1155777008836 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1155777008837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777008838 S-adenosylmethionine binding site [chemical binding]; other site 1155777008839 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1155777008840 dimer interface [polypeptide binding]; other site 1155777008841 catalytic triad [active] 1155777008842 peroxidatic and resolving cysteines [active] 1155777008843 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1155777008844 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1155777008845 RDD family; Region: RDD; pfam06271 1155777008846 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1155777008847 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1155777008848 tandem repeat interface [polypeptide binding]; other site 1155777008849 oligomer interface [polypeptide binding]; other site 1155777008850 active site residues [active] 1155777008851 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1155777008852 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1155777008853 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1155777008854 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1155777008855 active site 1155777008856 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155777008857 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1155777008858 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1155777008859 active site 1155777008860 acyl-activating enzyme (AAE) consensus motif; other site 1155777008861 putative CoA binding site [chemical binding]; other site 1155777008862 AMP binding site [chemical binding]; other site 1155777008863 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1155777008864 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1155777008865 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1155777008866 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1155777008867 Ligand Binding Site [chemical binding]; other site 1155777008868 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1155777008869 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155777008870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155777008871 catalytic residue [active] 1155777008872 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1155777008873 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1155777008874 TMPIT-like protein; Region: TMPIT; pfam07851 1155777008875 histidinol-phosphatase; Reviewed; Region: PRK08123 1155777008876 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1155777008877 active site 1155777008878 dimer interface [polypeptide binding]; other site 1155777008879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777008880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777008881 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1155777008882 GAF domain; Region: GAF_2; pfam13185 1155777008883 GAF domain; Region: GAF_3; pfam13492 1155777008884 GAF domain; Region: GAF_2; pfam13185 1155777008885 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1155777008886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1155777008887 metal binding site [ion binding]; metal-binding site 1155777008888 active site 1155777008889 I-site; other site 1155777008890 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1155777008891 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1155777008892 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777008893 RNA binding surface [nucleotide binding]; other site 1155777008894 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1155777008895 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1155777008896 NAD(P) binding site [chemical binding]; other site 1155777008897 catalytic residues [active] 1155777008898 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1155777008899 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1155777008900 positive control sigma-like factor; Validated; Region: PRK06930 1155777008901 DNA binding residues [nucleotide binding] 1155777008902 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1155777008903 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1155777008904 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1155777008905 heme-binding site [chemical binding]; other site 1155777008906 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1155777008907 FAD binding pocket [chemical binding]; other site 1155777008908 FAD binding motif [chemical binding]; other site 1155777008909 phosphate binding motif [ion binding]; other site 1155777008910 beta-alpha-beta structure motif; other site 1155777008911 NAD binding pocket [chemical binding]; other site 1155777008912 Heme binding pocket [chemical binding]; other site 1155777008913 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1155777008914 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1155777008915 proposed catalytic triad [active] 1155777008916 conserved cys residue [active] 1155777008917 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1155777008918 active site 1155777008919 catalytic triad [active] 1155777008920 oxyanion hole [active] 1155777008921 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155777008922 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1155777008923 Predicted transcriptional regulators [Transcription]; Region: COG1378 1155777008924 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1155777008925 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1155777008926 C-terminal domain interface [polypeptide binding]; other site 1155777008927 sugar binding site [chemical binding]; other site 1155777008928 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1155777008929 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1155777008930 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1155777008931 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1155777008932 active site 1155777008933 HIGH motif; other site 1155777008934 dimer interface [polypeptide binding]; other site 1155777008935 KMSKS motif; other site 1155777008936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777008937 RNA binding surface [nucleotide binding]; other site 1155777008938 acetyl-CoA synthetase; Provisional; Region: PRK04319 1155777008939 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1155777008940 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1155777008941 active site 1155777008942 acyl-activating enzyme (AAE) consensus motif; other site 1155777008943 putative CoA binding site [chemical binding]; other site 1155777008944 AMP binding site [chemical binding]; other site 1155777008945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777008946 Coenzyme A binding pocket [chemical binding]; other site 1155777008947 FOG: CBS domain [General function prediction only]; Region: COG0517 1155777008948 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1155777008949 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1155777008950 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1155777008951 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1155777008952 active site 1155777008953 Zn binding site [ion binding]; other site 1155777008954 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1155777008955 flagellar motor protein MotS; Reviewed; Region: PRK06925 1155777008956 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1155777008957 ligand binding site [chemical binding]; other site 1155777008958 flagellar motor protein MotP; Reviewed; Region: PRK06926 1155777008959 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1155777008960 catabolite control protein A; Region: ccpA; TIGR01481 1155777008961 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777008962 DNA binding site [nucleotide binding] 1155777008963 domain linker motif; other site 1155777008964 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1155777008965 dimerization interface [polypeptide binding]; other site 1155777008966 effector binding site; other site 1155777008967 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1155777008968 Chorismate mutase type II; Region: CM_2; cl00693 1155777008969 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1155777008970 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1155777008971 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1155777008972 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1155777008973 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1155777008974 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155777008975 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155777008976 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155777008977 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1155777008978 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155777008979 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1155777008980 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1155777008981 putative tRNA-binding site [nucleotide binding]; other site 1155777008982 hypothetical protein; Provisional; Region: PRK13668 1155777008983 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155777008984 catalytic residues [active] 1155777008985 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1155777008986 HPP family; Region: HPP; pfam04982 1155777008987 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1155777008988 CGNR zinc finger; Region: zf-CGNR; pfam11706 1155777008989 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155777008990 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1155777008991 oligomer interface [polypeptide binding]; other site 1155777008992 active site 1155777008993 metal binding site [ion binding]; metal-binding site 1155777008994 Predicted small secreted protein [Function unknown]; Region: COG5584 1155777008995 malate dehydrogenase; Provisional; Region: PRK13529 1155777008996 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1155777008997 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1155777008998 NAD(P) binding site [chemical binding]; other site 1155777008999 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1155777009000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777009001 S-adenosylmethionine binding site [chemical binding]; other site 1155777009002 YtzH-like protein; Region: YtzH; pfam14165 1155777009003 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1155777009004 active site 1155777009005 ATP binding site [chemical binding]; other site 1155777009006 Phosphotransferase enzyme family; Region: APH; pfam01636 1155777009007 substrate binding site [chemical binding]; other site 1155777009008 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1155777009009 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155777009010 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1155777009011 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1155777009012 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1155777009013 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1155777009014 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155777009015 dimer interface [polypeptide binding]; other site 1155777009016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777009017 catalytic residue [active] 1155777009018 dipeptidase PepV; Reviewed; Region: PRK07318 1155777009019 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1155777009020 active site 1155777009021 metal binding site [ion binding]; metal-binding site 1155777009022 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1155777009023 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1155777009024 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155777009025 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155777009026 Walker A/P-loop; other site 1155777009027 ATP binding site [chemical binding]; other site 1155777009028 Q-loop/lid; other site 1155777009029 ABC transporter signature motif; other site 1155777009030 Walker B; other site 1155777009031 D-loop; other site 1155777009032 H-loop/switch region; other site 1155777009033 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155777009034 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1155777009035 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155777009036 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777009037 RNA binding surface [nucleotide binding]; other site 1155777009038 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1155777009039 active site 1155777009040 uracil binding [chemical binding]; other site 1155777009041 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1155777009042 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155777009043 HI0933-like protein; Region: HI0933_like; pfam03486 1155777009044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155777009045 BCCT family transporter; Region: BCCT; pfam02028 1155777009046 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1155777009047 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777009048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777009049 DNA binding site [nucleotide binding] 1155777009050 domain linker motif; other site 1155777009051 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1155777009052 putative ligand binding site [chemical binding]; other site 1155777009053 putative dimerization interface [polypeptide binding]; other site 1155777009054 PBP superfamily domain; Region: PBP_like_2; cl17296 1155777009055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155777009056 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1155777009057 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1155777009058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777009059 dimer interface [polypeptide binding]; other site 1155777009060 conserved gate region; other site 1155777009061 putative PBP binding loops; other site 1155777009062 ABC-ATPase subunit interface; other site 1155777009063 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155777009064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777009065 dimer interface [polypeptide binding]; other site 1155777009066 conserved gate region; other site 1155777009067 putative PBP binding loops; other site 1155777009068 ABC-ATPase subunit interface; other site 1155777009069 alpha-galactosidase; Provisional; Region: PRK15076 1155777009070 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1155777009071 NAD binding site [chemical binding]; other site 1155777009072 sugar binding site [chemical binding]; other site 1155777009073 divalent metal binding site [ion binding]; other site 1155777009074 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155777009075 dimer interface [polypeptide binding]; other site 1155777009076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155777009077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777009078 Coenzyme A binding pocket [chemical binding]; other site 1155777009079 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155777009080 active site residue [active] 1155777009081 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1155777009082 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1155777009083 HIGH motif; other site 1155777009084 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155777009085 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155777009086 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1155777009087 active site 1155777009088 KMSKS motif; other site 1155777009089 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1155777009090 tRNA binding surface [nucleotide binding]; other site 1155777009091 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1155777009092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777009093 PAS domain; Region: PAS_9; pfam13426 1155777009094 putative active site [active] 1155777009095 heme pocket [chemical binding]; other site 1155777009096 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1155777009097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777009098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777009099 putative substrate translocation pore; other site 1155777009100 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1155777009101 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155777009102 FtsX-like permease family; Region: FtsX; pfam02687 1155777009103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155777009104 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155777009105 Walker A/P-loop; other site 1155777009106 ATP binding site [chemical binding]; other site 1155777009107 Q-loop/lid; other site 1155777009108 ABC transporter signature motif; other site 1155777009109 Walker B; other site 1155777009110 D-loop; other site 1155777009111 H-loop/switch region; other site 1155777009112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777009113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1155777009114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777009115 ATP binding site [chemical binding]; other site 1155777009116 Mg2+ binding site [ion binding]; other site 1155777009117 G-X-G motif; other site 1155777009118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777009119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777009120 active site 1155777009121 phosphorylation site [posttranslational modification] 1155777009122 intermolecular recognition site; other site 1155777009123 dimerization interface [polypeptide binding]; other site 1155777009124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777009125 DNA binding site [nucleotide binding] 1155777009126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155777009127 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155777009128 FtsX-like permease family; Region: FtsX; pfam02687 1155777009129 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155777009130 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155777009131 Walker A/P-loop; other site 1155777009132 ATP binding site [chemical binding]; other site 1155777009133 Q-loop/lid; other site 1155777009134 ABC transporter signature motif; other site 1155777009135 Walker B; other site 1155777009136 D-loop; other site 1155777009137 H-loop/switch region; other site 1155777009138 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1155777009139 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1155777009140 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777009141 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155777009142 Walker A/P-loop; other site 1155777009143 ATP binding site [chemical binding]; other site 1155777009144 Q-loop/lid; other site 1155777009145 ABC transporter signature motif; other site 1155777009146 Walker B; other site 1155777009147 D-loop; other site 1155777009148 H-loop/switch region; other site 1155777009149 Predicted transcriptional regulators [Transcription]; Region: COG1725 1155777009150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777009151 DNA-binding site [nucleotide binding]; DNA binding site 1155777009152 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1155777009153 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1155777009154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777009155 S-adenosylmethionine binding site [chemical binding]; other site 1155777009156 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155777009157 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1155777009158 active site 1155777009159 catalytic site [active] 1155777009160 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1155777009161 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1155777009162 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155777009163 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1155777009164 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1155777009165 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1155777009166 trimer interface [polypeptide binding]; other site 1155777009167 putative metal binding site [ion binding]; other site 1155777009168 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155777009169 Spore germination protein; Region: Spore_permease; cl17796 1155777009170 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1155777009171 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1155777009172 active site 1155777009173 dimer interface [polypeptide binding]; other site 1155777009174 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1155777009175 Ligand Binding Site [chemical binding]; other site 1155777009176 Molecular Tunnel; other site 1155777009177 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1155777009178 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1155777009179 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1155777009180 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1155777009181 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1155777009182 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1155777009183 active site 1155777009184 substrate-binding site [chemical binding]; other site 1155777009185 metal-binding site [ion binding] 1155777009186 ATP binding site [chemical binding]; other site 1155777009187 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1155777009188 Dienelactone hydrolase family; Region: DLH; pfam01738 1155777009189 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155777009190 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1155777009191 NMT1-like family; Region: NMT1_2; pfam13379 1155777009192 substrate binding pocket [chemical binding]; other site 1155777009193 membrane-bound complex binding site; other site 1155777009194 hinge residues; other site 1155777009195 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1155777009196 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1155777009197 Walker A/P-loop; other site 1155777009198 ATP binding site [chemical binding]; other site 1155777009199 Q-loop/lid; other site 1155777009200 ABC transporter signature motif; other site 1155777009201 Walker B; other site 1155777009202 D-loop; other site 1155777009203 H-loop/switch region; other site 1155777009204 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1155777009205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777009206 dimer interface [polypeptide binding]; other site 1155777009207 conserved gate region; other site 1155777009208 putative PBP binding loops; other site 1155777009209 ABC-ATPase subunit interface; other site 1155777009210 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1155777009211 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1155777009212 nudix motif; other site 1155777009213 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1155777009214 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1155777009215 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1155777009216 dimerization interface [polypeptide binding]; other site 1155777009217 DPS ferroxidase diiron center [ion binding]; other site 1155777009218 ion pore; other site 1155777009219 YtkA-like; Region: YtkA; pfam13115 1155777009220 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1155777009221 Haemolytic domain; Region: Haemolytic; pfam01809 1155777009222 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1155777009223 active site clefts [active] 1155777009224 zinc binding site [ion binding]; other site 1155777009225 dimer interface [polypeptide binding]; other site 1155777009226 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1155777009227 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1155777009228 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1155777009229 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1155777009230 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155777009231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777009232 ABC-ATPase subunit interface; other site 1155777009233 dimer interface [polypeptide binding]; other site 1155777009234 putative PBP binding regions; other site 1155777009235 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155777009236 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777009237 ABC-ATPase subunit interface; other site 1155777009238 dimer interface [polypeptide binding]; other site 1155777009239 putative PBP binding regions; other site 1155777009240 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1155777009241 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1155777009242 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155777009243 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155777009244 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1155777009245 metal binding site [ion binding]; metal-binding site 1155777009246 intersubunit interface [polypeptide binding]; other site 1155777009247 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1155777009248 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1155777009249 active site 1155777009250 octamer interface [polypeptide binding]; other site 1155777009251 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1155777009252 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1155777009253 acyl-activating enzyme (AAE) consensus motif; other site 1155777009254 putative AMP binding site [chemical binding]; other site 1155777009255 putative active site [active] 1155777009256 putative CoA binding site [chemical binding]; other site 1155777009257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155777009258 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1155777009259 substrate binding site [chemical binding]; other site 1155777009260 oxyanion hole (OAH) forming residues; other site 1155777009261 trimer interface [polypeptide binding]; other site 1155777009262 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1155777009263 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1155777009264 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1155777009265 dimer interface [polypeptide binding]; other site 1155777009266 tetramer interface [polypeptide binding]; other site 1155777009267 PYR/PP interface [polypeptide binding]; other site 1155777009268 TPP binding site [chemical binding]; other site 1155777009269 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1155777009270 TPP-binding site; other site 1155777009271 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1155777009272 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1155777009273 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1155777009274 TspO/MBR family; Region: TspO_MBR; cl01379 1155777009275 Predicted membrane protein [Function unknown]; Region: COG3859 1155777009276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1155777009277 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1155777009278 DinB superfamily; Region: DinB_2; pfam12867 1155777009279 DinB family; Region: DinB; cl17821 1155777009280 MOSC domain; Region: MOSC; pfam03473 1155777009281 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1155777009282 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1155777009283 active site 1155777009284 NAD binding site [chemical binding]; other site 1155777009285 metal binding site [ion binding]; metal-binding site 1155777009286 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1155777009287 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1155777009288 tetramerization interface [polypeptide binding]; other site 1155777009289 NAD(P) binding site [chemical binding]; other site 1155777009290 catalytic residues [active] 1155777009291 Predicted transcriptional regulators [Transcription]; Region: COG1510 1155777009292 MarR family; Region: MarR_2; pfam12802 1155777009293 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1155777009294 TrkA-N domain; Region: TrkA_N; pfam02254 1155777009295 TrkA-C domain; Region: TrkA_C; pfam02080 1155777009296 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155777009297 SH3-like domain; Region: SH3_8; pfam13457 1155777009298 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1155777009299 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1155777009300 heme-binding site [chemical binding]; other site 1155777009301 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1155777009302 FAD binding pocket [chemical binding]; other site 1155777009303 FAD binding motif [chemical binding]; other site 1155777009304 phosphate binding motif [ion binding]; other site 1155777009305 beta-alpha-beta structure motif; other site 1155777009306 NAD binding pocket [chemical binding]; other site 1155777009307 Heme binding pocket [chemical binding]; other site 1155777009308 Cupin; Region: Cupin_1; smart00835 1155777009309 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1155777009310 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155777009311 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155777009312 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155777009313 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155777009314 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1155777009315 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1155777009316 proposed catalytic triad [active] 1155777009317 conserved cys residue [active] 1155777009318 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1155777009319 Cache domain; Region: Cache_1; pfam02743 1155777009320 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1155777009321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777009322 dimerization interface [polypeptide binding]; other site 1155777009323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777009324 dimer interface [polypeptide binding]; other site 1155777009325 putative CheW interface [polypeptide binding]; other site 1155777009326 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1155777009327 Cache domain; Region: Cache_1; pfam02743 1155777009328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777009329 dimerization interface [polypeptide binding]; other site 1155777009330 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777009331 dimer interface [polypeptide binding]; other site 1155777009332 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1155777009333 putative CheW interface [polypeptide binding]; other site 1155777009334 Tar ligand binding domain homologue; Region: TarH; pfam02203 1155777009335 Cache domain; Region: Cache_1; pfam02743 1155777009336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777009337 dimerization interface [polypeptide binding]; other site 1155777009338 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1155777009339 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777009340 dimer interface [polypeptide binding]; other site 1155777009341 putative CheW interface [polypeptide binding]; other site 1155777009342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777009343 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1155777009344 Cache domain; Region: Cache_1; pfam02743 1155777009345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777009346 dimerization interface [polypeptide binding]; other site 1155777009347 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1155777009348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1155777009349 dimer interface [polypeptide binding]; other site 1155777009350 putative CheW interface [polypeptide binding]; other site 1155777009351 transglutaminase; Provisional; Region: tgl; PRK03187 1155777009352 Nitronate monooxygenase; Region: NMO; pfam03060 1155777009353 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1155777009354 FMN binding site [chemical binding]; other site 1155777009355 substrate binding site [chemical binding]; other site 1155777009356 putative catalytic residue [active] 1155777009357 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1155777009358 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155777009359 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155777009360 Ca binding site [ion binding]; other site 1155777009361 active site 1155777009362 catalytic site [active] 1155777009363 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1155777009364 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155777009365 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155777009366 Transporter associated domain; Region: CorC_HlyC; smart01091 1155777009367 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1155777009368 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1155777009369 Ion channel; Region: Ion_trans_2; pfam07885 1155777009370 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1155777009371 TrkA-N domain; Region: TrkA_N; pfam02254 1155777009372 YugN-like family; Region: YugN; pfam08868 1155777009373 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1155777009374 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1155777009375 active site 1155777009376 dimer interface [polypeptide binding]; other site 1155777009377 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1155777009378 dimer interface [polypeptide binding]; other site 1155777009379 active site 1155777009380 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155777009381 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155777009382 Isochorismatase family; Region: Isochorismatase; pfam00857 1155777009383 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1155777009384 catalytic triad [active] 1155777009385 dimer interface [polypeptide binding]; other site 1155777009386 conserved cis-peptide bond; other site 1155777009387 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1155777009388 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1155777009389 dimer interface [polypeptide binding]; other site 1155777009390 active site 1155777009391 metal binding site [ion binding]; metal-binding site 1155777009392 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1155777009393 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1155777009394 dimer interface [polypeptide binding]; other site 1155777009395 active site 1155777009396 metal binding site [ion binding]; metal-binding site 1155777009397 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1155777009398 general stress protein 13; Validated; Region: PRK08059 1155777009399 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155777009400 RNA binding site [nucleotide binding]; other site 1155777009401 hypothetical protein; Validated; Region: PRK07682 1155777009402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777009403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777009404 homodimer interface [polypeptide binding]; other site 1155777009405 catalytic residue [active] 1155777009406 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1155777009407 AsnC family; Region: AsnC_trans_reg; pfam01037 1155777009408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155777009409 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1155777009410 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1155777009411 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1155777009412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777009413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777009414 homodimer interface [polypeptide binding]; other site 1155777009415 catalytic residue [active] 1155777009416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777009417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777009418 dimer interface [polypeptide binding]; other site 1155777009419 phosphorylation site [posttranslational modification] 1155777009420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777009421 ATP binding site [chemical binding]; other site 1155777009422 Mg2+ binding site [ion binding]; other site 1155777009423 G-X-G motif; other site 1155777009424 Kinase associated protein B; Region: KapB; pfam08810 1155777009425 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1155777009426 active site 1155777009427 catalytic site [active] 1155777009428 substrate binding site [chemical binding]; other site 1155777009429 drug efflux system protein MdtG; Provisional; Region: PRK09874 1155777009430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777009431 putative substrate translocation pore; other site 1155777009432 Transglycosylase; Region: Transgly; pfam00912 1155777009433 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1155777009434 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1155777009435 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1155777009436 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1155777009437 PAS domain; Region: PAS; smart00091 1155777009438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777009439 ATP binding site [chemical binding]; other site 1155777009440 Mg2+ binding site [ion binding]; other site 1155777009441 G-X-G motif; other site 1155777009442 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1155777009443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777009444 active site 1155777009445 phosphorylation site [posttranslational modification] 1155777009446 intermolecular recognition site; other site 1155777009447 dimerization interface [polypeptide binding]; other site 1155777009448 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1155777009449 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1155777009450 ligand binding site [chemical binding]; other site 1155777009451 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1155777009452 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1155777009453 Walker A/P-loop; other site 1155777009454 ATP binding site [chemical binding]; other site 1155777009455 Q-loop/lid; other site 1155777009456 ABC transporter signature motif; other site 1155777009457 Walker B; other site 1155777009458 D-loop; other site 1155777009459 H-loop/switch region; other site 1155777009460 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1155777009461 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155777009462 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1155777009463 TM-ABC transporter signature motif; other site 1155777009464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155777009465 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1155777009466 TM-ABC transporter signature motif; other site 1155777009467 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1155777009468 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1155777009469 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1155777009470 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1155777009471 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1155777009472 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1155777009473 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1155777009474 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1155777009475 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1155777009476 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1155777009477 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1155777009478 CoenzymeA binding site [chemical binding]; other site 1155777009479 subunit interaction site [polypeptide binding]; other site 1155777009480 PHB binding site; other site 1155777009481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777009482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777009483 active site 1155777009484 phosphorylation site [posttranslational modification] 1155777009485 intermolecular recognition site; other site 1155777009486 dimerization interface [polypeptide binding]; other site 1155777009487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777009488 DNA binding residues [nucleotide binding] 1155777009489 dimerization interface [polypeptide binding]; other site 1155777009490 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1155777009491 protein binding site [polypeptide binding]; other site 1155777009492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155777009493 Histidine kinase; Region: HisKA_3; pfam07730 1155777009494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777009495 ATP binding site [chemical binding]; other site 1155777009496 Mg2+ binding site [ion binding]; other site 1155777009497 G-X-G motif; other site 1155777009498 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 1155777009499 substrate-Mg2+ binding site; other site 1155777009500 aspartate-rich region 2; other site 1155777009501 DegQ (SacQ) family; Region: DegQ; pfam08181 1155777009502 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1155777009503 EAL domain; Region: EAL; pfam00563 1155777009504 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1155777009505 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1155777009506 active site 1155777009507 Isochorismatase family; Region: Isochorismatase; pfam00857 1155777009508 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155777009509 catalytic triad [active] 1155777009510 conserved cis-peptide bond; other site 1155777009511 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1155777009512 YueH-like protein; Region: YueH; pfam14166 1155777009513 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1155777009514 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155777009515 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155777009516 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1155777009517 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1155777009518 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155777009519 Zn2+ binding site [ion binding]; other site 1155777009520 Mg2+ binding site [ion binding]; other site 1155777009521 short chain dehydrogenase; Provisional; Region: PRK06924 1155777009522 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1155777009523 NADP binding site [chemical binding]; other site 1155777009524 homodimer interface [polypeptide binding]; other site 1155777009525 active site 1155777009526 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1155777009527 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1155777009528 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1155777009529 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1155777009530 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1155777009531 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155777009532 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155777009533 Domain of unknown function DUF87; Region: DUF87; pfam01935 1155777009534 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1155777009535 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1155777009536 Uncharacterized small protein [Function unknown]; Region: COG5417 1155777009537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1155777009538 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1155777009539 CodY GAF-like domain; Region: CodY; pfam06018 1155777009540 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1155777009541 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1155777009542 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1155777009543 hexamer interface [polypeptide binding]; other site 1155777009544 ligand binding site [chemical binding]; other site 1155777009545 putative active site [active] 1155777009546 NAD(P) binding site [chemical binding]; other site 1155777009547 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1155777009548 MbtH-like protein; Region: MbtH; cl01279 1155777009549 Condensation domain; Region: Condensation; pfam00668 1155777009550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777009551 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1155777009552 acyl-activating enzyme (AAE) consensus motif; other site 1155777009553 AMP binding site [chemical binding]; other site 1155777009554 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777009555 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1155777009556 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777009557 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777009558 acyl-activating enzyme (AAE) consensus motif; other site 1155777009559 AMP binding site [chemical binding]; other site 1155777009560 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777009561 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1155777009562 hydrophobic substrate binding pocket; other site 1155777009563 Isochorismatase family; Region: Isochorismatase; pfam00857 1155777009564 active site 1155777009565 conserved cis-peptide bond; other site 1155777009566 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1155777009567 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1155777009568 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1155777009569 acyl-activating enzyme (AAE) consensus motif; other site 1155777009570 active site 1155777009571 AMP binding site [chemical binding]; other site 1155777009572 substrate binding site [chemical binding]; other site 1155777009573 isochorismate synthase DhbC; Validated; Region: PRK06923 1155777009574 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1155777009575 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1155777009576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155777009577 NAD(P) binding site [chemical binding]; other site 1155777009578 active site 1155777009579 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1155777009580 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1155777009581 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1155777009582 Moco binding site; other site 1155777009583 metal coordination site [ion binding]; other site 1155777009584 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1155777009585 Predicted permease [General function prediction only]; Region: COG2056 1155777009586 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1155777009587 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1155777009588 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1155777009589 interface (dimer of trimers) [polypeptide binding]; other site 1155777009590 Substrate-binding/catalytic site; other site 1155777009591 Zn-binding sites [ion binding]; other site 1155777009592 Divergent PAP2 family; Region: DUF212; pfam02681 1155777009593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1155777009594 Putative membrane protein; Region: YuiB; pfam14068 1155777009595 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1155777009596 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1155777009597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777009598 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1155777009599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155777009600 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777009601 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1155777009602 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1155777009603 active site 1155777009604 Integral membrane protein DUF95; Region: DUF95; pfam01944 1155777009605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1155777009606 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155777009607 Walker A/P-loop; other site 1155777009608 ATP binding site [chemical binding]; other site 1155777009609 Q-loop/lid; other site 1155777009610 ABC transporter signature motif; other site 1155777009611 Walker B; other site 1155777009612 D-loop; other site 1155777009613 H-loop/switch region; other site 1155777009614 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155777009615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155777009616 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1155777009617 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1155777009618 putative NAD(P) binding site [chemical binding]; other site 1155777009619 active site 1155777009620 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1155777009621 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1155777009622 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1155777009623 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1155777009624 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1155777009625 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1155777009626 Nucleoside recognition; Region: Gate; pfam07670 1155777009627 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1155777009628 hypothetical protein; Provisional; Region: PRK13669 1155777009629 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1155777009630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777009631 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1155777009632 NifU-like domain; Region: NifU; pfam01106 1155777009633 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1155777009634 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1155777009635 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1155777009636 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155777009637 homoserine kinase; Provisional; Region: PRK01212 1155777009638 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155777009639 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155777009640 threonine synthase; Reviewed; Region: PRK06721 1155777009641 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1155777009642 homodimer interface [polypeptide binding]; other site 1155777009643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777009644 catalytic residue [active] 1155777009645 homoserine dehydrogenase; Provisional; Region: PRK06349 1155777009646 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1155777009647 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1155777009648 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1155777009649 spore coat protein YutH; Region: spore_yutH; TIGR02905 1155777009650 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1155777009651 tetramer interfaces [polypeptide binding]; other site 1155777009652 binuclear metal-binding site [ion binding]; other site 1155777009653 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1155777009654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777009655 active site 1155777009656 motif I; other site 1155777009657 motif II; other site 1155777009658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777009659 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1155777009660 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1155777009661 lipoyl synthase; Provisional; Region: PRK05481 1155777009662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777009663 FeS/SAM binding site; other site 1155777009664 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155777009665 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155777009666 sporulation protein YunB; Region: spo_yunB; TIGR02832 1155777009667 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1155777009668 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1155777009669 active site 1155777009670 metal binding site [ion binding]; metal-binding site 1155777009671 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155777009672 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1155777009673 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1155777009674 allantoinase; Provisional; Region: PRK06189 1155777009675 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1155777009676 active site 1155777009677 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1155777009678 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1155777009679 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1155777009680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777009681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777009682 binding surface 1155777009683 TPR motif; other site 1155777009684 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777009685 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777009686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777009687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777009688 putative substrate translocation pore; other site 1155777009689 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1155777009690 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155777009691 catalytic residue [active] 1155777009692 allantoate amidohydrolase; Reviewed; Region: PRK09290 1155777009693 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1155777009694 active site 1155777009695 metal binding site [ion binding]; metal-binding site 1155777009696 dimer interface [polypeptide binding]; other site 1155777009697 Endonuclease I; Region: Endonuclease_1; pfam04231 1155777009698 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1155777009699 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1155777009700 Walker A/P-loop; other site 1155777009701 ATP binding site [chemical binding]; other site 1155777009702 Q-loop/lid; other site 1155777009703 ABC transporter signature motif; other site 1155777009704 Walker B; other site 1155777009705 D-loop; other site 1155777009706 H-loop/switch region; other site 1155777009707 TOBE domain; Region: TOBE_2; pfam08402 1155777009708 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1155777009709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777009710 DNA-binding site [nucleotide binding]; DNA binding site 1155777009711 UTRA domain; Region: UTRA; pfam07702 1155777009712 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155777009713 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1155777009714 substrate binding site [chemical binding]; other site 1155777009715 ATP binding site [chemical binding]; other site 1155777009716 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155777009717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777009718 dimer interface [polypeptide binding]; other site 1155777009719 conserved gate region; other site 1155777009720 putative PBP binding loops; other site 1155777009721 ABC-ATPase subunit interface; other site 1155777009722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777009723 dimer interface [polypeptide binding]; other site 1155777009724 conserved gate region; other site 1155777009725 putative PBP binding loops; other site 1155777009726 ABC-ATPase subunit interface; other site 1155777009727 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1155777009728 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155777009729 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1155777009730 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1155777009731 putative active site [active] 1155777009732 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1155777009733 dimer interface [polypeptide binding]; other site 1155777009734 active site 1155777009735 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155777009736 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1155777009737 DNA binding residues [nucleotide binding] 1155777009738 dimer interface [polypeptide binding]; other site 1155777009739 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1155777009740 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1155777009741 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1155777009742 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1155777009743 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1155777009744 GIY-YIG motif/motif A; other site 1155777009745 active site 1155777009746 catalytic site [active] 1155777009747 putative DNA binding site [nucleotide binding]; other site 1155777009748 metal binding site [ion binding]; metal-binding site 1155777009749 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1155777009750 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1155777009751 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1155777009752 chitosan binding site [chemical binding]; other site 1155777009753 catalytic residues [active] 1155777009754 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1155777009755 FeS assembly protein SufB; Region: sufB; TIGR01980 1155777009756 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1155777009757 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1155777009758 trimerization site [polypeptide binding]; other site 1155777009759 active site 1155777009760 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1155777009761 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1155777009762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155777009763 catalytic residue [active] 1155777009764 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1155777009765 FeS assembly protein SufD; Region: sufD; TIGR01981 1155777009766 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1155777009767 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1155777009768 Walker A/P-loop; other site 1155777009769 ATP binding site [chemical binding]; other site 1155777009770 Q-loop/lid; other site 1155777009771 ABC transporter signature motif; other site 1155777009772 Walker B; other site 1155777009773 D-loop; other site 1155777009774 H-loop/switch region; other site 1155777009775 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1155777009776 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1155777009777 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1155777009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777009779 ABC-ATPase subunit interface; other site 1155777009780 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1155777009781 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1155777009782 Walker A/P-loop; other site 1155777009783 ATP binding site [chemical binding]; other site 1155777009784 Q-loop/lid; other site 1155777009785 ABC transporter signature motif; other site 1155777009786 Walker B; other site 1155777009787 D-loop; other site 1155777009788 H-loop/switch region; other site 1155777009789 NIL domain; Region: NIL; pfam09383 1155777009790 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1155777009791 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155777009792 catalytic residues [active] 1155777009793 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1155777009794 putative active site [active] 1155777009795 putative metal binding site [ion binding]; other site 1155777009796 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1155777009797 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1155777009798 lipoyl attachment site [posttranslational modification]; other site 1155777009799 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1155777009800 ArsC family; Region: ArsC; pfam03960 1155777009801 putative ArsC-like catalytic residues; other site 1155777009802 putative TRX-like catalytic residues [active] 1155777009803 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1155777009804 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1155777009805 active site 1155777009806 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1155777009807 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1155777009808 dimer interface [polypeptide binding]; other site 1155777009809 active site 1155777009810 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1155777009811 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1155777009812 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1155777009813 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1155777009814 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1155777009815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155777009816 substrate binding site [chemical binding]; other site 1155777009817 oxyanion hole (OAH) forming residues; other site 1155777009818 trimer interface [polypeptide binding]; other site 1155777009819 YuzL-like protein; Region: YuzL; pfam14115 1155777009820 Proline dehydrogenase; Region: Pro_dh; cl03282 1155777009821 Coat F domain; Region: Coat_F; pfam07875 1155777009822 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777009823 MarR family; Region: MarR; pfam01047 1155777009824 MarR family; Region: MarR_2; cl17246 1155777009825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777009826 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777009827 putative substrate translocation pore; other site 1155777009828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777009829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777009830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777009831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777009832 dimerization interface [polypeptide binding]; other site 1155777009833 acetoacetate decarboxylase; Provisional; Region: PRK02265 1155777009834 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1155777009835 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1155777009836 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1155777009837 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1155777009838 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155777009839 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155777009840 Walker A/P-loop; other site 1155777009841 ATP binding site [chemical binding]; other site 1155777009842 Q-loop/lid; other site 1155777009843 ABC transporter signature motif; other site 1155777009844 Walker B; other site 1155777009845 D-loop; other site 1155777009846 H-loop/switch region; other site 1155777009847 YusW-like protein; Region: YusW; pfam14039 1155777009848 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1155777009849 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1155777009850 active site 1155777009851 Zn binding site [ion binding]; other site 1155777009852 short chain dehydrogenase; Provisional; Region: PRK06914 1155777009853 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1155777009854 NADP binding site [chemical binding]; other site 1155777009855 active site 1155777009856 steroid binding site; other site 1155777009857 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1155777009858 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1155777009859 dimerization interface [polypeptide binding]; other site 1155777009860 DPS ferroxidase diiron center [ion binding]; other site 1155777009861 ion pore; other site 1155777009862 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1155777009863 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1155777009864 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1155777009865 protein binding site [polypeptide binding]; other site 1155777009866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777009867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777009868 active site 1155777009869 phosphorylation site [posttranslational modification] 1155777009870 intermolecular recognition site; other site 1155777009871 dimerization interface [polypeptide binding]; other site 1155777009872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777009873 DNA binding site [nucleotide binding] 1155777009874 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777009875 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777009876 dimerization interface [polypeptide binding]; other site 1155777009877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777009878 dimer interface [polypeptide binding]; other site 1155777009879 phosphorylation site [posttranslational modification] 1155777009880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777009881 ATP binding site [chemical binding]; other site 1155777009882 Mg2+ binding site [ion binding]; other site 1155777009883 G-X-G motif; other site 1155777009884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777009885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777009886 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1155777009887 Class II fumarases; Region: Fumarase_classII; cd01362 1155777009888 active site 1155777009889 tetramer interface [polypeptide binding]; other site 1155777009890 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1155777009891 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1155777009892 Spore germination protein; Region: Spore_permease; pfam03845 1155777009893 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1155777009894 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1155777009895 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777009896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777009897 active site 1155777009898 phosphorylation site [posttranslational modification] 1155777009899 intermolecular recognition site; other site 1155777009900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777009901 DNA binding residues [nucleotide binding] 1155777009902 dimerization interface [polypeptide binding]; other site 1155777009903 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155777009904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777009905 dimerization interface [polypeptide binding]; other site 1155777009906 Histidine kinase; Region: HisKA_3; pfam07730 1155777009907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777009908 ATP binding site [chemical binding]; other site 1155777009909 Mg2+ binding site [ion binding]; other site 1155777009910 G-X-G motif; other site 1155777009911 Predicted membrane protein [Function unknown]; Region: COG4758 1155777009912 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1155777009913 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1155777009914 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1155777009915 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1155777009916 PspA/IM30 family; Region: PspA_IM30; pfam04012 1155777009917 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1155777009918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777009919 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155777009920 putative substrate translocation pore; other site 1155777009921 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1155777009922 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155777009923 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155777009924 Walker A/P-loop; other site 1155777009925 ATP binding site [chemical binding]; other site 1155777009926 Q-loop/lid; other site 1155777009927 ABC transporter signature motif; other site 1155777009928 Walker B; other site 1155777009929 D-loop; other site 1155777009930 H-loop/switch region; other site 1155777009931 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1155777009932 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1155777009933 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777009934 ABC-ATPase subunit interface; other site 1155777009935 dimer interface [polypeptide binding]; other site 1155777009936 putative PBP binding regions; other site 1155777009937 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155777009938 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1155777009939 putative binding site residues; other site 1155777009940 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1155777009941 classical (c) SDRs; Region: SDR_c; cd05233 1155777009942 NAD(P) binding site [chemical binding]; other site 1155777009943 active site 1155777009944 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1155777009945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777009946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777009947 dimer interface [polypeptide binding]; other site 1155777009948 phosphorylation site [posttranslational modification] 1155777009949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777009950 ATP binding site [chemical binding]; other site 1155777009951 Mg2+ binding site [ion binding]; other site 1155777009952 G-X-G motif; other site 1155777009953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777009954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777009955 active site 1155777009956 phosphorylation site [posttranslational modification] 1155777009957 intermolecular recognition site; other site 1155777009958 dimerization interface [polypeptide binding]; other site 1155777009959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777009960 DNA binding site [nucleotide binding] 1155777009961 hypothetical protein; Provisional; Region: PRK14082 1155777009962 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1155777009963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155777009964 DNA binding residues [nucleotide binding] 1155777009965 YvrJ protein family; Region: YvrJ; pfam12841 1155777009966 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1155777009967 Cupin; Region: Cupin_1; smart00835 1155777009968 Cupin; Region: Cupin_1; smart00835 1155777009969 Regulatory protein YrvL; Region: YrvL; pfam14184 1155777009970 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155777009971 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155777009972 Walker A/P-loop; other site 1155777009973 ATP binding site [chemical binding]; other site 1155777009974 Q-loop/lid; other site 1155777009975 ABC transporter signature motif; other site 1155777009976 Walker B; other site 1155777009977 D-loop; other site 1155777009978 H-loop/switch region; other site 1155777009979 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1155777009980 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777009981 ABC-ATPase subunit interface; other site 1155777009982 dimer interface [polypeptide binding]; other site 1155777009983 putative PBP binding regions; other site 1155777009984 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155777009985 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777009986 ABC-ATPase subunit interface; other site 1155777009987 dimer interface [polypeptide binding]; other site 1155777009988 putative PBP binding regions; other site 1155777009989 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155777009990 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1155777009991 putative ligand binding residues [chemical binding]; other site 1155777009992 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1155777009993 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1155777009994 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1155777009995 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; pfam09575 1155777009996 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1155777009997 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1155777009998 Sulfatase; Region: Sulfatase; pfam00884 1155777009999 DNA binding domain, excisionase family; Region: excise; TIGR01764 1155777010000 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1155777010001 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1155777010002 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1155777010003 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1155777010004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010005 dimer interface [polypeptide binding]; other site 1155777010006 conserved gate region; other site 1155777010007 putative PBP binding loops; other site 1155777010008 ABC-ATPase subunit interface; other site 1155777010009 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777010010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777010011 active site 1155777010012 phosphorylation site [posttranslational modification] 1155777010013 intermolecular recognition site; other site 1155777010014 dimerization interface [polypeptide binding]; other site 1155777010015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777010016 DNA binding residues [nucleotide binding] 1155777010017 dimerization interface [polypeptide binding]; other site 1155777010018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155777010019 Histidine kinase; Region: HisKA_3; pfam07730 1155777010020 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155777010021 Mg2+ binding site [ion binding]; other site 1155777010022 G-X-G motif; other site 1155777010023 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777010024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777010025 Walker A/P-loop; other site 1155777010026 ATP binding site [chemical binding]; other site 1155777010027 Q-loop/lid; other site 1155777010028 ABC transporter signature motif; other site 1155777010029 Walker B; other site 1155777010030 D-loop; other site 1155777010031 H-loop/switch region; other site 1155777010032 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1155777010033 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1155777010034 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1155777010035 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1155777010036 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155777010037 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155777010038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155777010039 active site 1155777010040 catalytic tetrad [active] 1155777010041 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1155777010042 sulfite reductase subunit beta; Provisional; Region: PRK13504 1155777010043 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1155777010044 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1155777010045 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1155777010046 Flavodoxin; Region: Flavodoxin_1; pfam00258 1155777010047 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1155777010048 FAD binding pocket [chemical binding]; other site 1155777010049 FAD binding motif [chemical binding]; other site 1155777010050 catalytic residues [active] 1155777010051 NAD binding pocket [chemical binding]; other site 1155777010052 phosphate binding motif [ion binding]; other site 1155777010053 beta-alpha-beta structure motif; other site 1155777010054 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1155777010055 Family description; Region: UvrD_C_2; pfam13538 1155777010056 Predicted membrane protein [Function unknown]; Region: COG2860 1155777010057 UPF0126 domain; Region: UPF0126; pfam03458 1155777010058 UPF0126 domain; Region: UPF0126; pfam03458 1155777010059 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 1155777010060 active site 1155777010061 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1155777010062 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1155777010063 Thioredoxin; Region: Thioredoxin_4; pfam13462 1155777010064 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155777010065 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155777010066 metal-binding site [ion binding] 1155777010067 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155777010068 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155777010069 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155777010070 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155777010071 metal-binding site [ion binding] 1155777010072 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155777010073 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155777010074 metal-binding site [ion binding] 1155777010075 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155777010076 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155777010077 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155777010078 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155777010079 metal-binding site [ion binding] 1155777010080 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1155777010081 putative homodimer interface [polypeptide binding]; other site 1155777010082 putative homotetramer interface [polypeptide binding]; other site 1155777010083 putative allosteric switch controlling residues; other site 1155777010084 putative metal binding site [ion binding]; other site 1155777010085 putative homodimer-homodimer interface [polypeptide binding]; other site 1155777010086 putative oxidoreductase; Provisional; Region: PRK11579 1155777010087 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155777010088 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155777010089 azoreductase; Reviewed; Region: PRK00170 1155777010090 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155777010091 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1155777010092 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1155777010093 active site 1155777010094 non-prolyl cis peptide bond; other site 1155777010095 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1155777010096 catalytic residues [active] 1155777010097 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1155777010098 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1155777010099 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155777010100 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155777010101 Walker A/P-loop; other site 1155777010102 ATP binding site [chemical binding]; other site 1155777010103 Q-loop/lid; other site 1155777010104 ABC transporter signature motif; other site 1155777010105 Walker B; other site 1155777010106 D-loop; other site 1155777010107 H-loop/switch region; other site 1155777010108 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155777010109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010110 dimer interface [polypeptide binding]; other site 1155777010111 conserved gate region; other site 1155777010112 putative PBP binding loops; other site 1155777010113 ABC-ATPase subunit interface; other site 1155777010114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010115 dimer interface [polypeptide binding]; other site 1155777010116 conserved gate region; other site 1155777010117 putative PBP binding loops; other site 1155777010118 ABC-ATPase subunit interface; other site 1155777010119 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155777010120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155777010121 substrate binding pocket [chemical binding]; other site 1155777010122 membrane-bound complex binding site; other site 1155777010123 hinge residues; other site 1155777010124 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1155777010125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155777010126 substrate binding pocket [chemical binding]; other site 1155777010127 membrane-bound complex binding site; other site 1155777010128 hinge residues; other site 1155777010129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155777010130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777010131 Coenzyme A binding pocket [chemical binding]; other site 1155777010132 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1155777010133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777010134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777010135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777010136 dimerization interface [polypeptide binding]; other site 1155777010137 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1155777010138 classical (c) SDRs; Region: SDR_c; cd05233 1155777010139 NAD(P) binding site [chemical binding]; other site 1155777010140 active site 1155777010141 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1155777010142 RNAase interaction site [polypeptide binding]; other site 1155777010143 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1155777010144 RNAase interaction site [polypeptide binding]; other site 1155777010145 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1155777010146 SmpB-tmRNA interface; other site 1155777010147 ribonuclease R; Region: RNase_R; TIGR02063 1155777010148 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1155777010149 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1155777010150 RNB domain; Region: RNB; pfam00773 1155777010151 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1155777010152 RNA binding site [nucleotide binding]; other site 1155777010153 Esterase/lipase [General function prediction only]; Region: COG1647 1155777010154 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155777010155 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1155777010156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777010157 salt bridge; other site 1155777010158 non-specific DNA binding site [nucleotide binding]; other site 1155777010159 sequence-specific DNA binding site [nucleotide binding]; other site 1155777010160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155777010161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777010162 non-specific DNA binding site [nucleotide binding]; other site 1155777010163 salt bridge; other site 1155777010164 sequence-specific DNA binding site [nucleotide binding]; other site 1155777010165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155777010166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777010167 non-specific DNA binding site [nucleotide binding]; other site 1155777010168 salt bridge; other site 1155777010169 sequence-specific DNA binding site [nucleotide binding]; other site 1155777010170 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155777010171 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155777010172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777010173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777010174 dimer interface [polypeptide binding]; other site 1155777010175 phosphorylation site [posttranslational modification] 1155777010176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777010177 ATP binding site [chemical binding]; other site 1155777010178 Mg2+ binding site [ion binding]; other site 1155777010179 G-X-G motif; other site 1155777010180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777010181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777010182 active site 1155777010183 phosphorylation site [posttranslational modification] 1155777010184 intermolecular recognition site; other site 1155777010185 dimerization interface [polypeptide binding]; other site 1155777010186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777010187 DNA binding site [nucleotide binding] 1155777010188 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1155777010189 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155777010190 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1155777010191 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155777010192 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1155777010193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777010194 Walker A/P-loop; other site 1155777010195 ATP binding site [chemical binding]; other site 1155777010196 Q-loop/lid; other site 1155777010197 ABC transporter signature motif; other site 1155777010198 Walker B; other site 1155777010199 D-loop; other site 1155777010200 H-loop/switch region; other site 1155777010201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010202 dimer interface [polypeptide binding]; other site 1155777010203 conserved gate region; other site 1155777010204 putative PBP binding loops; other site 1155777010205 ABC-ATPase subunit interface; other site 1155777010206 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1155777010207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010208 dimer interface [polypeptide binding]; other site 1155777010209 conserved gate region; other site 1155777010210 putative PBP binding loops; other site 1155777010211 ABC-ATPase subunit interface; other site 1155777010212 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1155777010213 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1155777010214 Walker A/P-loop; other site 1155777010215 ATP binding site [chemical binding]; other site 1155777010216 Q-loop/lid; other site 1155777010217 ABC transporter signature motif; other site 1155777010218 Walker B; other site 1155777010219 D-loop; other site 1155777010220 H-loop/switch region; other site 1155777010221 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1155777010222 Predicted transcriptional regulators [Transcription]; Region: COG1510 1155777010223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777010224 putative DNA binding site [nucleotide binding]; other site 1155777010225 putative Zn2+ binding site [ion binding]; other site 1155777010226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010227 dimer interface [polypeptide binding]; other site 1155777010228 conserved gate region; other site 1155777010229 putative PBP binding loops; other site 1155777010230 ABC-ATPase subunit interface; other site 1155777010231 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1155777010232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010233 dimer interface [polypeptide binding]; other site 1155777010234 conserved gate region; other site 1155777010235 putative PBP binding loops; other site 1155777010236 ABC-ATPase subunit interface; other site 1155777010237 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1155777010238 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1155777010239 Walker A/P-loop; other site 1155777010240 ATP binding site [chemical binding]; other site 1155777010241 Q-loop/lid; other site 1155777010242 ABC transporter signature motif; other site 1155777010243 Walker B; other site 1155777010244 D-loop; other site 1155777010245 H-loop/switch region; other site 1155777010246 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1155777010247 Predicted transcriptional regulators [Transcription]; Region: COG1510 1155777010248 MarR family; Region: MarR_2; pfam12802 1155777010249 membrane protein, MarC family; Region: TIGR00427 1155777010250 Predicted membrane protein [Function unknown]; Region: COG4640 1155777010251 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1155777010252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777010253 Coenzyme A binding pocket [chemical binding]; other site 1155777010254 enolase; Provisional; Region: eno; PRK00077 1155777010255 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1155777010256 dimer interface [polypeptide binding]; other site 1155777010257 metal binding site [ion binding]; metal-binding site 1155777010258 substrate binding pocket [chemical binding]; other site 1155777010259 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1155777010260 phosphoglyceromutase; Provisional; Region: PRK05434 1155777010261 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1155777010262 triosephosphate isomerase; Provisional; Region: PRK14565 1155777010263 substrate binding site [chemical binding]; other site 1155777010264 dimer interface [polypeptide binding]; other site 1155777010265 catalytic triad [active] 1155777010266 Phosphoglycerate kinase; Region: PGK; pfam00162 1155777010267 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1155777010268 substrate binding site [chemical binding]; other site 1155777010269 hinge regions; other site 1155777010270 ADP binding site [chemical binding]; other site 1155777010271 catalytic site [active] 1155777010272 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1155777010273 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1155777010274 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155777010275 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1155777010276 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1155777010277 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1155777010278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777010279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777010280 DNA-binding site [nucleotide binding]; DNA binding site 1155777010281 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777010282 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1155777010283 putative dimerization interface [polypeptide binding]; other site 1155777010284 putative ligand binding site [chemical binding]; other site 1155777010285 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1155777010286 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1155777010287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777010288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777010289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777010290 dimerization interface [polypeptide binding]; other site 1155777010291 EamA-like transporter family; Region: EamA; pfam00892 1155777010292 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1155777010293 EamA-like transporter family; Region: EamA; pfam00892 1155777010294 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1155777010295 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155777010296 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155777010297 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155777010298 putative active site [active] 1155777010299 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1155777010300 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1155777010301 N- and C-terminal domain interface [polypeptide binding]; other site 1155777010302 active site 1155777010303 catalytic site [active] 1155777010304 metal binding site [ion binding]; metal-binding site 1155777010305 carbohydrate binding site [chemical binding]; other site 1155777010306 ATP binding site [chemical binding]; other site 1155777010307 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1155777010308 GntP family permease; Region: GntP_permease; pfam02447 1155777010309 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1155777010310 iron-sulfur cluster-binding protein; Region: TIGR00273 1155777010311 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1155777010312 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1155777010313 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1155777010314 Cysteine-rich domain; Region: CCG; pfam02754 1155777010315 Cysteine-rich domain; Region: CCG; pfam02754 1155777010316 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1155777010317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777010318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777010319 homodimer interface [polypeptide binding]; other site 1155777010320 catalytic residue [active] 1155777010321 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1155777010322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777010323 DNA-binding site [nucleotide binding]; DNA binding site 1155777010324 FCD domain; Region: FCD; pfam07729 1155777010325 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1155777010326 L-lactate permease; Region: Lactate_perm; pfam02652 1155777010327 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1155777010328 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1155777010329 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1155777010330 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1155777010331 YvfG protein; Region: YvfG; pfam09628 1155777010332 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1155777010333 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1155777010334 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1155777010335 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1155777010336 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1155777010337 inhibitor-cofactor binding pocket; inhibition site 1155777010338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777010339 catalytic residue [active] 1155777010340 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1155777010341 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1155777010342 putative trimer interface [polypeptide binding]; other site 1155777010343 putative CoA binding site [chemical binding]; other site 1155777010344 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1155777010345 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155777010346 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1155777010347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155777010348 active site 1155777010349 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1155777010350 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1155777010351 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1155777010352 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155777010353 active site 1155777010354 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155777010355 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1155777010356 putative ADP-binding pocket [chemical binding]; other site 1155777010357 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155777010358 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1155777010359 active site 1155777010360 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1155777010361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155777010362 putative ADP-binding pocket [chemical binding]; other site 1155777010363 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1155777010364 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1155777010365 NAD(P) binding site [chemical binding]; other site 1155777010366 homodimer interface [polypeptide binding]; other site 1155777010367 substrate binding site [chemical binding]; other site 1155777010368 active site 1155777010369 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1155777010370 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155777010371 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1155777010372 Chain length determinant protein; Region: Wzz; cl15801 1155777010373 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155777010374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777010375 non-specific DNA binding site [nucleotide binding]; other site 1155777010376 salt bridge; other site 1155777010377 sequence-specific DNA binding site [nucleotide binding]; other site 1155777010378 Anti-repressor SinI; Region: SinI; pfam08671 1155777010379 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1155777010380 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1155777010381 substrate binding pocket [chemical binding]; other site 1155777010382 catalytic triad [active] 1155777010383 RibD C-terminal domain; Region: RibD_C; cl17279 1155777010384 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155777010385 Predicted membrane protein [Function unknown]; Region: COG2364 1155777010386 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155777010387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777010388 Coenzyme A binding pocket [chemical binding]; other site 1155777010389 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1155777010390 hypothetical protein; Provisional; Region: PRK00872 1155777010391 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155777010392 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155777010393 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155777010394 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1155777010395 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155777010396 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1155777010397 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1155777010398 substrate binding [chemical binding]; other site 1155777010399 active site 1155777010400 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1155777010401 galactoside permease; Reviewed; Region: lacY; PRK09528 1155777010402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777010403 putative substrate translocation pore; other site 1155777010404 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777010405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777010406 DNA binding site [nucleotide binding] 1155777010407 domain linker motif; other site 1155777010408 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1155777010409 dimerization interface [polypeptide binding]; other site 1155777010410 ligand binding site [chemical binding]; other site 1155777010411 sodium binding site [ion binding]; other site 1155777010412 Clp protease; Region: CLP_protease; pfam00574 1155777010413 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1155777010414 oligomer interface [polypeptide binding]; other site 1155777010415 active site residues [active] 1155777010416 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1155777010417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777010418 motif II; other site 1155777010419 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155777010420 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155777010421 Ca binding site [ion binding]; other site 1155777010422 active site 1155777010423 catalytic site [active] 1155777010424 maltose phosphorylase; Provisional; Region: PRK13807 1155777010425 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1155777010426 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1155777010427 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1155777010428 Predicted integral membrane protein [Function unknown]; Region: COG5521 1155777010429 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155777010430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010431 dimer interface [polypeptide binding]; other site 1155777010432 conserved gate region; other site 1155777010433 ABC-ATPase subunit interface; other site 1155777010434 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1155777010435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155777010436 dimer interface [polypeptide binding]; other site 1155777010437 conserved gate region; other site 1155777010438 putative PBP binding loops; other site 1155777010439 ABC-ATPase subunit interface; other site 1155777010440 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1155777010441 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155777010442 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1155777010443 homodimer interface [polypeptide binding]; other site 1155777010444 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1155777010445 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1155777010446 active site 1155777010447 homodimer interface [polypeptide binding]; other site 1155777010448 catalytic site [active] 1155777010449 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777010450 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777010451 DNA binding site [nucleotide binding] 1155777010452 domain linker motif; other site 1155777010453 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155777010454 ligand binding site [chemical binding]; other site 1155777010455 dimerization interface [polypeptide binding]; other site 1155777010456 TIGR00730 family protein; Region: TIGR00730 1155777010457 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1155777010458 metal binding site [ion binding]; metal-binding site 1155777010459 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1155777010460 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1155777010461 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1155777010462 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1155777010463 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1155777010464 active site clefts [active] 1155777010465 zinc binding site [ion binding]; other site 1155777010466 dimer interface [polypeptide binding]; other site 1155777010467 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1155777010468 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1155777010469 dimerization interface [polypeptide binding]; other site 1155777010470 ligand binding site [chemical binding]; other site 1155777010471 NADP binding site [chemical binding]; other site 1155777010472 catalytic site [active] 1155777010473 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1155777010474 active site 1155777010475 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1155777010476 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1155777010477 dimerization domain swap beta strand [polypeptide binding]; other site 1155777010478 regulatory protein interface [polypeptide binding]; other site 1155777010479 active site 1155777010480 regulatory phosphorylation site [posttranslational modification]; other site 1155777010481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1155777010482 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1155777010483 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1155777010484 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1155777010485 phosphate binding site [ion binding]; other site 1155777010486 putative substrate binding pocket [chemical binding]; other site 1155777010487 dimer interface [polypeptide binding]; other site 1155777010488 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1155777010489 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1155777010490 putative active site [active] 1155777010491 nucleotide binding site [chemical binding]; other site 1155777010492 nudix motif; other site 1155777010493 putative metal binding site [ion binding]; other site 1155777010494 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1155777010495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155777010496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777010497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1155777010498 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 1155777010499 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155777010500 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155777010501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777010502 binding surface 1155777010503 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1155777010504 TPR motif; other site 1155777010505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777010506 TPR motif; other site 1155777010507 binding surface 1155777010508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777010509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777010510 dimer interface [polypeptide binding]; other site 1155777010511 phosphorylation site [posttranslational modification] 1155777010512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777010513 ATP binding site [chemical binding]; other site 1155777010514 Mg2+ binding site [ion binding]; other site 1155777010515 G-X-G motif; other site 1155777010516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777010517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777010518 active site 1155777010519 phosphorylation site [posttranslational modification] 1155777010520 intermolecular recognition site; other site 1155777010521 dimerization interface [polypeptide binding]; other site 1155777010522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777010523 DNA binding site [nucleotide binding] 1155777010524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155777010525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777010526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777010527 Walker A/P-loop; other site 1155777010528 ATP binding site [chemical binding]; other site 1155777010529 Q-loop/lid; other site 1155777010530 ABC transporter signature motif; other site 1155777010531 Walker B; other site 1155777010532 D-loop; other site 1155777010533 H-loop/switch region; other site 1155777010534 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1155777010535 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1155777010536 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1155777010537 metal binding site [ion binding]; metal-binding site 1155777010538 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1155777010539 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1155777010540 substrate binding site [chemical binding]; other site 1155777010541 glutamase interaction surface [polypeptide binding]; other site 1155777010542 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1155777010543 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1155777010544 catalytic residues [active] 1155777010545 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1155777010546 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1155777010547 putative active site [active] 1155777010548 oxyanion strand; other site 1155777010549 catalytic triad [active] 1155777010550 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1155777010551 putative active site pocket [active] 1155777010552 4-fold oligomerization interface [polypeptide binding]; other site 1155777010553 metal binding residues [ion binding]; metal-binding site 1155777010554 3-fold/trimer interface [polypeptide binding]; other site 1155777010555 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1155777010556 histidinol dehydrogenase; Region: hisD; TIGR00069 1155777010557 NAD binding site [chemical binding]; other site 1155777010558 dimerization interface [polypeptide binding]; other site 1155777010559 product binding site; other site 1155777010560 substrate binding site [chemical binding]; other site 1155777010561 zinc binding site [ion binding]; other site 1155777010562 catalytic residues [active] 1155777010563 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1155777010564 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1155777010565 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1155777010566 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1155777010567 dimer interface [polypeptide binding]; other site 1155777010568 motif 1; other site 1155777010569 active site 1155777010570 motif 2; other site 1155777010571 motif 3; other site 1155777010572 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1155777010573 putative active site [active] 1155777010574 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1155777010575 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1155777010576 trimer interface [polypeptide binding]; other site 1155777010577 active site 1155777010578 substrate binding site [chemical binding]; other site 1155777010579 CoA binding site [chemical binding]; other site 1155777010580 pyrophosphatase PpaX; Provisional; Region: PRK13288 1155777010581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1155777010582 motif I; other site 1155777010583 active site 1155777010584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777010585 motif II; other site 1155777010586 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1155777010587 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1155777010588 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1155777010589 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1155777010590 Hpr binding site; other site 1155777010591 active site 1155777010592 homohexamer subunit interaction site [polypeptide binding]; other site 1155777010593 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1155777010594 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1155777010595 active site 1155777010596 dimer interface [polypeptide binding]; other site 1155777010597 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1155777010598 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1155777010599 active site 1155777010600 trimer interface [polypeptide binding]; other site 1155777010601 allosteric site; other site 1155777010602 active site lid [active] 1155777010603 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1155777010604 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155777010605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777010606 DNA-binding site [nucleotide binding]; DNA binding site 1155777010607 UTRA domain; Region: UTRA; pfam07702 1155777010608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777010609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777010610 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1155777010611 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1155777010612 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155777010613 putative active site [active] 1155777010614 putative metal binding site [ion binding]; other site 1155777010615 Predicted membrane protein [Function unknown]; Region: COG1950 1155777010616 PspC domain; Region: PspC; pfam04024 1155777010617 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1155777010618 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1155777010619 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1155777010620 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1155777010621 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1155777010622 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1155777010623 excinuclease ABC subunit B; Provisional; Region: PRK05298 1155777010624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777010625 ATP binding site [chemical binding]; other site 1155777010626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777010627 nucleotide binding region [chemical binding]; other site 1155777010628 ATP-binding site [chemical binding]; other site 1155777010629 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1155777010630 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1155777010631 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1155777010632 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1155777010633 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1155777010634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777010635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777010636 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1155777010637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777010638 putative substrate translocation pore; other site 1155777010639 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1155777010640 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 1155777010641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155777010642 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155777010643 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777010644 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1155777010645 Walker A/P-loop; other site 1155777010646 ATP binding site [chemical binding]; other site 1155777010647 Q-loop/lid; other site 1155777010648 ABC transporter signature motif; other site 1155777010649 Walker B; other site 1155777010650 D-loop; other site 1155777010651 H-loop/switch region; other site 1155777010652 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777010653 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777010654 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777010655 acyl-activating enzyme (AAE) consensus motif; other site 1155777010656 AMP binding site [chemical binding]; other site 1155777010657 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777010658 Condensation domain; Region: Condensation; pfam00668 1155777010659 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777010660 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777010661 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777010662 acyl-activating enzyme (AAE) consensus motif; other site 1155777010663 AMP binding site [chemical binding]; other site 1155777010664 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777010665 Condensation domain; Region: Condensation; pfam00668 1155777010666 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777010667 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777010668 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777010669 acyl-activating enzyme (AAE) consensus motif; other site 1155777010670 AMP binding site [chemical binding]; other site 1155777010671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777010672 Condensation domain; Region: Condensation; pfam00668 1155777010673 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777010674 acyl-CoA synthetase; Validated; Region: PRK09192 1155777010675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1155777010676 acyl-activating enzyme (AAE) consensus motif; other site 1155777010677 AMP binding site [chemical binding]; other site 1155777010678 active site 1155777010679 CoA binding site [chemical binding]; other site 1155777010680 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777010681 Condensation domain; Region: Condensation; pfam00668 1155777010682 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777010683 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1155777010684 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777010685 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1155777010686 acyl-activating enzyme (AAE) consensus motif; other site 1155777010687 AMP binding site [chemical binding]; other site 1155777010688 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777010689 Condensation domain; Region: Condensation; pfam00668 1155777010690 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1155777010691 Condensation domain; Region: Condensation; pfam00668 1155777010692 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777010693 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777010694 acyl-activating enzyme (AAE) consensus motif; other site 1155777010695 AMP binding site [chemical binding]; other site 1155777010696 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777010697 Condensation domain; Region: Condensation; pfam00668 1155777010698 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777010699 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777010700 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777010701 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1155777010702 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1155777010703 acyl-activating enzyme (AAE) consensus motif; other site 1155777010704 AMP binding site [chemical binding]; other site 1155777010705 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777010706 Condensation domain; Region: Condensation; pfam00668 1155777010707 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155777010708 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155777010709 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155777010710 acyl-activating enzyme (AAE) consensus motif; other site 1155777010711 AMP binding site [chemical binding]; other site 1155777010712 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155777010713 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1155777010714 NADP binding site [chemical binding]; other site 1155777010715 homodimer interface [polypeptide binding]; other site 1155777010716 active site 1155777010717 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1155777010718 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1155777010719 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1155777010720 C-terminal peptidase (prc); Region: prc; TIGR00225 1155777010721 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1155777010722 protein binding site [polypeptide binding]; other site 1155777010723 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1155777010724 Catalytic dyad [active] 1155777010725 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155777010726 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1155777010727 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1155777010728 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1155777010729 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1155777010730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777010731 Walker A/P-loop; other site 1155777010732 ATP binding site [chemical binding]; other site 1155777010733 Q-loop/lid; other site 1155777010734 ABC transporter signature motif; other site 1155777010735 Walker B; other site 1155777010736 D-loop; other site 1155777010737 H-loop/switch region; other site 1155777010738 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1155777010739 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1155777010740 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155777010741 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777010742 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777010743 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155777010744 peptide chain release factor 2; Provisional; Region: PRK06746 1155777010745 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1155777010746 RF-1 domain; Region: RF-1; pfam00472 1155777010747 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1155777010748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1155777010749 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1155777010750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1155777010751 nucleotide binding region [chemical binding]; other site 1155777010752 ATP-binding site [chemical binding]; other site 1155777010753 SEC-C motif; Region: SEC-C; pfam02810 1155777010754 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1155777010755 30S subunit binding site; other site 1155777010756 Flagellar protein FliT; Region: FliT; pfam05400 1155777010757 flagellar protein FliS; Validated; Region: fliS; PRK05685 1155777010758 flagellar capping protein; Validated; Region: fliD; PRK07737 1155777010759 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1155777010760 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1155777010761 flagellin; Provisional; Region: PRK12804 1155777010762 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1155777010763 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1155777010764 carbon storage regulator; Provisional; Region: PRK01712 1155777010765 flagellar assembly protein FliW; Provisional; Region: PRK13285 1155777010766 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1155777010767 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1155777010768 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1155777010769 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1155777010770 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1155777010771 FlgN protein; Region: FlgN; pfam05130 1155777010772 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1155777010773 flagellar operon protein TIGR03826; Region: YvyF 1155777010774 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777010775 active site 1155777010776 Late competence development protein ComFB; Region: ComFB; pfam10719 1155777010777 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1155777010778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777010779 ATP binding site [chemical binding]; other site 1155777010780 putative Mg++ binding site [ion binding]; other site 1155777010781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777010782 nucleotide binding region [chemical binding]; other site 1155777010783 ATP-binding site [chemical binding]; other site 1155777010784 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155777010785 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155777010786 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777010787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777010788 active site 1155777010789 phosphorylation site [posttranslational modification] 1155777010790 intermolecular recognition site; other site 1155777010791 dimerization interface [polypeptide binding]; other site 1155777010792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777010793 DNA binding residues [nucleotide binding] 1155777010794 dimerization interface [polypeptide binding]; other site 1155777010795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155777010796 Histidine kinase; Region: HisKA_3; pfam07730 1155777010797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777010798 ATP binding site [chemical binding]; other site 1155777010799 Mg2+ binding site [ion binding]; other site 1155777010800 G-X-G motif; other site 1155777010801 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1155777010802 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1155777010803 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1155777010804 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1155777010805 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1155777010806 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1155777010807 Mg++ binding site [ion binding]; other site 1155777010808 putative catalytic motif [active] 1155777010809 substrate binding site [chemical binding]; other site 1155777010810 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1155777010811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155777010812 putative homodimer interface [polypeptide binding]; other site 1155777010813 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155777010814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155777010815 active site 1155777010816 O-Antigen ligase; Region: Wzy_C; pfam04932 1155777010817 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1155777010818 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1155777010819 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1155777010820 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1155777010821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155777010822 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1155777010823 colanic acid exporter; Provisional; Region: PRK10459 1155777010824 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1155777010825 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1155777010826 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1155777010827 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1155777010828 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1155777010829 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1155777010830 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1155777010831 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1155777010832 active site 1155777010833 metal binding site [ion binding]; metal-binding site 1155777010834 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1155777010835 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1155777010836 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1155777010837 Stage II sporulation protein; Region: SpoIID; pfam08486 1155777010838 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1155777010839 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1155777010840 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1155777010841 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1155777010842 active site 1155777010843 homodimer interface [polypeptide binding]; other site 1155777010844 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1155777010845 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1155777010846 active site 1155777010847 tetramer interface; other site 1155777010848 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1155777010849 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1155777010850 Walker A/P-loop; other site 1155777010851 ATP binding site [chemical binding]; other site 1155777010852 Q-loop/lid; other site 1155777010853 ABC transporter signature motif; other site 1155777010854 Walker B; other site 1155777010855 D-loop; other site 1155777010856 H-loop/switch region; other site 1155777010857 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1155777010858 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155777010859 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1155777010860 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1155777010861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155777010862 active site 1155777010863 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1155777010864 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1155777010865 active site 1155777010866 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1155777010867 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1155777010868 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1155777010869 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1155777010870 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1155777010871 Bacterial SH3 domain; Region: SH3_3; pfam08239 1155777010872 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1155777010873 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1155777010874 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1155777010875 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1155777010876 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1155777010877 Spore germination protein; Region: Spore_permease; pfam03845 1155777010878 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1155777010879 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1155777010880 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1155777010881 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1155777010882 Probable Catalytic site; other site 1155777010883 metal-binding site 1155777010884 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1155777010885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777010886 S-adenosylmethionine binding site [chemical binding]; other site 1155777010887 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1155777010888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777010889 putative substrate translocation pore; other site 1155777010890 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1155777010891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777010892 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155777010893 active site 1155777010894 motif I; other site 1155777010895 motif II; other site 1155777010896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777010897 Septum formation initiator; Region: DivIC; cl17659 1155777010898 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 1155777010899 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155777010900 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155777010901 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155777010902 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155777010903 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1155777010904 NlpC/P60 family; Region: NLPC_P60; pfam00877 1155777010905 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1155777010906 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1155777010907 putative active site [active] 1155777010908 putative metal binding site [ion binding]; other site 1155777010909 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 1155777010910 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1155777010911 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155777010912 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1155777010913 Spore germination protein; Region: Spore_permease; cl17796 1155777010914 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1155777010915 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1155777010916 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777010917 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777010918 DNA binding site [nucleotide binding] 1155777010919 domain linker motif; other site 1155777010920 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1155777010921 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155777010922 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1155777010923 substrate binding site [chemical binding]; other site 1155777010924 dimer interface [polypeptide binding]; other site 1155777010925 ATP binding site [chemical binding]; other site 1155777010926 D-ribose pyranase; Provisional; Region: PRK11797 1155777010927 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1155777010928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777010929 Walker A/P-loop; other site 1155777010930 ATP binding site [chemical binding]; other site 1155777010931 Q-loop/lid; other site 1155777010932 ABC transporter signature motif; other site 1155777010933 Walker B; other site 1155777010934 D-loop; other site 1155777010935 H-loop/switch region; other site 1155777010936 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1155777010937 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1155777010938 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1155777010939 TM-ABC transporter signature motif; other site 1155777010940 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1155777010941 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1155777010942 ligand binding site [chemical binding]; other site 1155777010943 dimerization interface [polypeptide binding]; other site 1155777010944 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1155777010945 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1155777010946 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1155777010947 acetolactate synthase; Reviewed; Region: PRK08617 1155777010948 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1155777010949 PYR/PP interface [polypeptide binding]; other site 1155777010950 dimer interface [polypeptide binding]; other site 1155777010951 TPP binding site [chemical binding]; other site 1155777010952 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155777010953 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1155777010954 TPP-binding site [chemical binding]; other site 1155777010955 dimer interface [polypeptide binding]; other site 1155777010956 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1155777010957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777010958 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1155777010959 putative dimerization interface [polypeptide binding]; other site 1155777010960 putative substrate binding pocket [chemical binding]; other site 1155777010961 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1155777010962 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1155777010963 transmembrane helices; other site 1155777010964 CotH protein; Region: CotH; pfam08757 1155777010965 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1155777010966 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1155777010967 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1155777010968 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1155777010969 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1155777010970 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777010971 putative DNA binding site [nucleotide binding]; other site 1155777010972 putative Zn2+ binding site [ion binding]; other site 1155777010973 AsnC family; Region: AsnC_trans_reg; pfam01037 1155777010974 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1155777010975 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1155777010976 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1155777010977 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155777010978 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777010979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777010980 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155777010981 dimerization interface [polypeptide binding]; other site 1155777010982 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1155777010983 Active_site [active] 1155777010984 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1155777010985 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 1155777010986 LXG domain of WXG superfamily; Region: LXG; pfam04740 1155777010987 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1155777010988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1155777010989 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1155777010990 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1155777010991 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1155777010992 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1155777010993 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1155777010994 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1155777010995 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1155777010996 Nucleotide binding site [chemical binding]; other site 1155777010997 DTAP/Switch II; other site 1155777010998 Switch I; other site 1155777010999 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1155777011000 Chain length determinant protein; Region: Wzz; cl15801 1155777011001 SWIM zinc finger; Region: SWIM; pfam04434 1155777011002 SNF2 Helicase protein; Region: DUF3670; pfam12419 1155777011003 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1155777011004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777011005 ATP binding site [chemical binding]; other site 1155777011006 putative Mg++ binding site [ion binding]; other site 1155777011007 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1155777011008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777011009 nucleotide binding region [chemical binding]; other site 1155777011010 ATP-binding site [chemical binding]; other site 1155777011011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777011012 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155777011013 active site 1155777011014 motif I; other site 1155777011015 motif II; other site 1155777011016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777011017 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155777011018 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1155777011019 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155777011020 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155777011021 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155777011022 dimer interface [polypeptide binding]; other site 1155777011023 ssDNA binding site [nucleotide binding]; other site 1155777011024 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155777011025 YwpF-like protein; Region: YwpF; pfam14183 1155777011026 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1155777011027 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1155777011028 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1155777011029 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777011030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777011031 binding surface 1155777011032 TPR motif; other site 1155777011033 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777011034 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1155777011035 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1155777011036 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1155777011037 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1155777011038 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1155777011039 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1155777011040 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1155777011041 MreB and similar proteins; Region: MreB_like; cd10225 1155777011042 nucleotide binding site [chemical binding]; other site 1155777011043 Mg binding site [ion binding]; other site 1155777011044 putative protofilament interaction site [polypeptide binding]; other site 1155777011045 RodZ interaction site [polypeptide binding]; other site 1155777011046 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1155777011047 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777011048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777011049 putative Zn2+ binding site [ion binding]; other site 1155777011050 putative DNA binding site [nucleotide binding]; other site 1155777011051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777011052 putative substrate translocation pore; other site 1155777011053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777011054 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1155777011055 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1155777011056 Na binding site [ion binding]; other site 1155777011057 putative substrate binding site [chemical binding]; other site 1155777011058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777011059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777011060 putative substrate translocation pore; other site 1155777011061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777011062 Isochorismatase family; Region: Isochorismatase; pfam00857 1155777011063 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155777011064 catalytic triad [active] 1155777011065 conserved cis-peptide bond; other site 1155777011066 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1155777011067 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1155777011068 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1155777011069 cell division protein FtsW; Region: ftsW; TIGR02614 1155777011070 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1155777011071 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1155777011072 active site 1155777011073 VanZ like family; Region: VanZ; pfam04892 1155777011074 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155777011075 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155777011076 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1155777011077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777011078 Coenzyme A binding pocket [chemical binding]; other site 1155777011079 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1155777011080 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1155777011081 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1155777011082 putative active site [active] 1155777011083 catalytic site [active] 1155777011084 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1155777011085 putative active site [active] 1155777011086 catalytic site [active] 1155777011087 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1155777011088 Predicted transcriptional regulator [Transcription]; Region: COG1959 1155777011089 Transcriptional regulator; Region: Rrf2; pfam02082 1155777011090 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1155777011091 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1155777011092 subunit interactions [polypeptide binding]; other site 1155777011093 active site 1155777011094 flap region; other site 1155777011095 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1155777011096 gamma-beta subunit interface [polypeptide binding]; other site 1155777011097 alpha-beta subunit interface [polypeptide binding]; other site 1155777011098 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1155777011099 alpha-gamma subunit interface [polypeptide binding]; other site 1155777011100 beta-gamma subunit interface [polypeptide binding]; other site 1155777011101 CsbD-like; Region: CsbD; pfam05532 1155777011102 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777011103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777011104 binding surface 1155777011105 TPR motif; other site 1155777011106 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1155777011107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155777011108 FeS/SAM binding site; other site 1155777011109 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1155777011110 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1155777011111 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1155777011112 metal ion-dependent adhesion site (MIDAS); other site 1155777011113 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1155777011114 metal ion-dependent adhesion site (MIDAS); other site 1155777011115 Stage II sporulation protein; Region: SpoIID; pfam08486 1155777011116 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1155777011117 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1155777011118 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1155777011119 hinge; other site 1155777011120 active site 1155777011121 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1155777011122 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1155777011123 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1155777011124 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1155777011125 gamma subunit interface [polypeptide binding]; other site 1155777011126 epsilon subunit interface [polypeptide binding]; other site 1155777011127 LBP interface [polypeptide binding]; other site 1155777011128 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1155777011129 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155777011130 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1155777011131 alpha subunit interaction interface [polypeptide binding]; other site 1155777011132 Walker A motif; other site 1155777011133 ATP binding site [chemical binding]; other site 1155777011134 Walker B motif; other site 1155777011135 inhibitor binding site; inhibition site 1155777011136 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155777011137 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1155777011138 core domain interface [polypeptide binding]; other site 1155777011139 delta subunit interface [polypeptide binding]; other site 1155777011140 epsilon subunit interface [polypeptide binding]; other site 1155777011141 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1155777011142 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155777011143 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1155777011144 beta subunit interaction interface [polypeptide binding]; other site 1155777011145 Walker A motif; other site 1155777011146 ATP binding site [chemical binding]; other site 1155777011147 Walker B motif; other site 1155777011148 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155777011149 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1155777011150 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1155777011151 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1155777011152 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1155777011153 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1155777011154 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1155777011155 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1155777011156 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1155777011157 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155777011158 active site 1155777011159 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1155777011160 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1155777011161 dimer interface [polypeptide binding]; other site 1155777011162 active site 1155777011163 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1155777011164 folate binding site [chemical binding]; other site 1155777011165 hypothetical protein; Provisional; Region: PRK13690 1155777011166 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1155777011167 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1155777011168 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1155777011169 active site 1155777011170 Predicted membrane protein [Function unknown]; Region: COG1971 1155777011171 Domain of unknown function DUF; Region: DUF204; pfam02659 1155777011172 Domain of unknown function DUF; Region: DUF204; pfam02659 1155777011173 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1155777011174 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1155777011175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155777011176 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1155777011177 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1155777011178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777011179 S-adenosylmethionine binding site [chemical binding]; other site 1155777011180 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1155777011181 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1155777011182 RF-1 domain; Region: RF-1; pfam00472 1155777011183 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1155777011184 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777011185 putative metal binding site [ion binding]; other site 1155777011186 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1155777011187 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1155777011188 DNA binding residues [nucleotide binding] 1155777011189 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1155777011190 malate dehydrogenase; Provisional; Region: PRK13529 1155777011191 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1155777011192 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1155777011193 NAD(P) binding site [chemical binding]; other site 1155777011194 thymidine kinase; Provisional; Region: PRK04296 1155777011195 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1155777011196 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1155777011197 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1155777011198 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1155777011199 RNA binding site [nucleotide binding]; other site 1155777011200 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1155777011201 multimer interface [polypeptide binding]; other site 1155777011202 Walker A motif; other site 1155777011203 ATP binding site [chemical binding]; other site 1155777011204 Walker B motif; other site 1155777011205 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1155777011206 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1155777011207 putative active site [active] 1155777011208 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1155777011209 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1155777011210 hinge; other site 1155777011211 active site 1155777011212 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1155777011213 active site 1155777011214 intersubunit interactions; other site 1155777011215 catalytic residue [active] 1155777011216 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1155777011217 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1155777011218 intersubunit interface [polypeptide binding]; other site 1155777011219 active site 1155777011220 zinc binding site [ion binding]; other site 1155777011221 Na+ binding site [ion binding]; other site 1155777011222 Response regulator receiver domain; Region: Response_reg; pfam00072 1155777011223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777011224 active site 1155777011225 phosphorylation site [posttranslational modification] 1155777011226 intermolecular recognition site; other site 1155777011227 dimerization interface [polypeptide binding]; other site 1155777011228 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1155777011229 CTP synthetase; Validated; Region: pyrG; PRK05380 1155777011230 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1155777011231 Catalytic site [active] 1155777011232 active site 1155777011233 UTP binding site [chemical binding]; other site 1155777011234 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1155777011235 active site 1155777011236 putative oxyanion hole; other site 1155777011237 catalytic triad [active] 1155777011238 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1155777011239 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1155777011240 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1155777011241 Cysteine-rich domain; Region: CCG; pfam02754 1155777011242 Cysteine-rich domain; Region: CCG; pfam02754 1155777011243 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1155777011244 PLD-like domain; Region: PLDc_2; pfam13091 1155777011245 putative active site [active] 1155777011246 catalytic site [active] 1155777011247 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1155777011248 PLD-like domain; Region: PLDc_2; pfam13091 1155777011249 putative active site [active] 1155777011250 catalytic site [active] 1155777011251 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1155777011252 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155777011253 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777011254 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1155777011255 Walker A/P-loop; other site 1155777011256 ATP binding site [chemical binding]; other site 1155777011257 Q-loop/lid; other site 1155777011258 ABC transporter signature motif; other site 1155777011259 Walker B; other site 1155777011260 D-loop; other site 1155777011261 H-loop/switch region; other site 1155777011262 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1155777011263 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1155777011264 putative active site [active] 1155777011265 catalytic site [active] 1155777011266 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1155777011267 putative active site [active] 1155777011268 catalytic site [active] 1155777011269 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155777011270 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777011271 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1155777011272 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1155777011273 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1155777011274 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1155777011275 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1155777011276 [4Fe-4S] binding site [ion binding]; other site 1155777011277 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1155777011278 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1155777011279 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1155777011280 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1155777011281 molybdopterin cofactor binding site; other site 1155777011282 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1155777011283 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1155777011284 ligand binding site [chemical binding]; other site 1155777011285 flexible hinge region; other site 1155777011286 YwiC-like protein; Region: YwiC; pfam14256 1155777011287 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1155777011288 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1155777011289 ligand binding site [chemical binding]; other site 1155777011290 flexible hinge region; other site 1155777011291 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1155777011292 putative switch regulator; other site 1155777011293 non-specific DNA interactions [nucleotide binding]; other site 1155777011294 DNA binding site [nucleotide binding] 1155777011295 sequence specific DNA binding site [nucleotide binding]; other site 1155777011296 putative cAMP binding site [chemical binding]; other site 1155777011297 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1155777011298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777011299 putative substrate translocation pore; other site 1155777011300 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1155777011301 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1155777011302 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1155777011303 active site 1155777011304 HIGH motif; other site 1155777011305 KMSK motif region; other site 1155777011306 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1155777011307 tRNA binding surface [nucleotide binding]; other site 1155777011308 anticodon binding site; other site 1155777011309 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1155777011310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777011311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155777011312 binding surface 1155777011313 TPR motif; other site 1155777011314 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777011315 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155777011316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155777011317 non-specific DNA binding site [nucleotide binding]; other site 1155777011318 salt bridge; other site 1155777011319 sequence-specific DNA binding site [nucleotide binding]; other site 1155777011320 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1155777011321 Integral membrane protein DUF95; Region: DUF95; pfam01944 1155777011322 agmatinase; Region: agmatinase; TIGR01230 1155777011323 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1155777011324 putative active site [active] 1155777011325 Mn binding site [ion binding]; other site 1155777011326 spermidine synthase; Provisional; Region: PRK00811 1155777011327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1155777011328 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1155777011329 Transglycosylase; Region: Transgly; pfam00912 1155777011330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1155777011331 YwhD family; Region: YwhD; pfam08741 1155777011332 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1155777011333 Peptidase family M50; Region: Peptidase_M50; pfam02163 1155777011334 active site 1155777011335 putative substrate binding region [chemical binding]; other site 1155777011336 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1155777011337 active site 1 [active] 1155777011338 dimer interface [polypeptide binding]; other site 1155777011339 hexamer interface [polypeptide binding]; other site 1155777011340 active site 2 [active] 1155777011341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777011342 dimerization interface [polypeptide binding]; other site 1155777011343 putative DNA binding site [nucleotide binding]; other site 1155777011344 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777011345 putative Zn2+ binding site [ion binding]; other site 1155777011346 amino acid transporter; Region: 2A0306; TIGR00909 1155777011347 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1155777011348 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1155777011349 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1155777011350 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155777011351 Zn2+ binding site [ion binding]; other site 1155777011352 Mg2+ binding site [ion binding]; other site 1155777011353 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1155777011354 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1155777011355 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1155777011356 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777011357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777011358 Walker A/P-loop; other site 1155777011359 ATP binding site [chemical binding]; other site 1155777011360 Q-loop/lid; other site 1155777011361 ABC transporter signature motif; other site 1155777011362 Walker B; other site 1155777011363 D-loop; other site 1155777011364 H-loop/switch region; other site 1155777011365 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155777011366 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1155777011367 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155777011368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777011369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777011370 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1155777011371 putative dimerization interface [polypeptide binding]; other site 1155777011372 Predicted membrane protein [Function unknown]; Region: COG2855 1155777011373 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1155777011374 putative heme peroxidase; Provisional; Region: PRK12276 1155777011375 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1155777011376 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1155777011377 putative NAD(P) binding site [chemical binding]; other site 1155777011378 putative active site [active] 1155777011379 transaminase; Reviewed; Region: PRK08068 1155777011380 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777011381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777011382 homodimer interface [polypeptide binding]; other site 1155777011383 catalytic residue [active] 1155777011384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777011385 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155777011386 putative substrate translocation pore; other site 1155777011387 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1155777011388 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1155777011389 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1155777011390 classical (c) SDRs; Region: SDR_c; cd05233 1155777011391 NAD(P) binding site [chemical binding]; other site 1155777011392 active site 1155777011393 Cupin domain; Region: Cupin_2; pfam07883 1155777011394 Cupin domain; Region: Cupin_2; pfam07883 1155777011395 Prephenate dehydratase; Region: PDT; pfam00800 1155777011396 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777011397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777011398 putative substrate translocation pore; other site 1155777011399 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1155777011400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777011401 putative substrate translocation pore; other site 1155777011402 S-methylmethionine transporter; Provisional; Region: PRK11387 1155777011403 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1155777011404 putative metal binding site [ion binding]; other site 1155777011405 putative dimer interface [polypeptide binding]; other site 1155777011406 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1155777011407 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1155777011408 Glutamate binding site [chemical binding]; other site 1155777011409 homodimer interface [polypeptide binding]; other site 1155777011410 NAD binding site [chemical binding]; other site 1155777011411 catalytic residues [active] 1155777011412 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1155777011413 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1155777011414 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1155777011415 NAD(P) binding site [chemical binding]; other site 1155777011416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777011417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777011418 dimer interface [polypeptide binding]; other site 1155777011419 phosphorylation site [posttranslational modification] 1155777011420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777011421 ATP binding site [chemical binding]; other site 1155777011422 Mg2+ binding site [ion binding]; other site 1155777011423 G-X-G motif; other site 1155777011424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777011425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777011426 active site 1155777011427 phosphorylation site [posttranslational modification] 1155777011428 intermolecular recognition site; other site 1155777011429 dimerization interface [polypeptide binding]; other site 1155777011430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777011431 DNA binding site [nucleotide binding] 1155777011432 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1155777011433 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1155777011434 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1155777011435 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155777011436 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777011437 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1155777011438 Walker A/P-loop; other site 1155777011439 ATP binding site [chemical binding]; other site 1155777011440 Q-loop/lid; other site 1155777011441 ABC transporter signature motif; other site 1155777011442 Walker B; other site 1155777011443 D-loop; other site 1155777011444 H-loop/switch region; other site 1155777011445 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1155777011446 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1155777011447 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1155777011448 NADP binding site [chemical binding]; other site 1155777011449 active site 1155777011450 putative substrate binding site [chemical binding]; other site 1155777011451 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1155777011452 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1155777011453 NAD binding site [chemical binding]; other site 1155777011454 substrate binding site [chemical binding]; other site 1155777011455 homodimer interface [polypeptide binding]; other site 1155777011456 active site 1155777011457 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1155777011458 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1155777011459 substrate binding site; other site 1155777011460 tetramer interface; other site 1155777011461 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1155777011462 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155777011463 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1155777011464 ligand binding site; other site 1155777011465 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1155777011466 NeuB family; Region: NeuB; pfam03102 1155777011467 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1155777011468 NeuB binding interface [polypeptide binding]; other site 1155777011469 putative substrate binding site [chemical binding]; other site 1155777011470 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155777011471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777011472 Coenzyme A binding pocket [chemical binding]; other site 1155777011473 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1155777011474 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1155777011475 inhibitor-cofactor binding pocket; inhibition site 1155777011476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777011477 catalytic residue [active] 1155777011478 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1155777011479 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155777011480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155777011481 active site 1155777011482 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1155777011483 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1155777011484 Permease family; Region: Xan_ur_permease; pfam00860 1155777011485 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1155777011486 ligand binding site [chemical binding]; other site 1155777011487 active site 1155777011488 UGI interface [polypeptide binding]; other site 1155777011489 catalytic site [active] 1155777011490 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155777011491 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155777011492 active site 1155777011493 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155777011494 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1155777011495 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1155777011496 dimer interface [polypeptide binding]; other site 1155777011497 substrate binding site [chemical binding]; other site 1155777011498 ATP binding site [chemical binding]; other site 1155777011499 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1155777011500 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1155777011501 substrate binding [chemical binding]; other site 1155777011502 active site 1155777011503 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1155777011504 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1155777011505 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155777011506 active site turn [active] 1155777011507 phosphorylation site [posttranslational modification] 1155777011508 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155777011509 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155777011510 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155777011511 PRD domain; Region: PRD; pfam00874 1155777011512 PRD domain; Region: PRD; pfam00874 1155777011513 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1155777011514 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1155777011515 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1155777011516 putative active site [active] 1155777011517 catalytic triad [active] 1155777011518 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1155777011519 PA/protease domain interface [polypeptide binding]; other site 1155777011520 putative integrin binding motif; other site 1155777011521 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1155777011522 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1155777011523 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1155777011524 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1155777011525 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1155777011526 dimer interface [polypeptide binding]; other site 1155777011527 FMN binding site [chemical binding]; other site 1155777011528 NADPH bind site [chemical binding]; other site 1155777011529 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1155777011530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155777011531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777011532 Coenzyme A binding pocket [chemical binding]; other site 1155777011533 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1155777011534 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1155777011535 Subunit I/III interface [polypeptide binding]; other site 1155777011536 Subunit III/IV interface [polypeptide binding]; other site 1155777011537 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1155777011538 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1155777011539 D-pathway; other site 1155777011540 Putative ubiquinol binding site [chemical binding]; other site 1155777011541 Low-spin heme (heme b) binding site [chemical binding]; other site 1155777011542 Putative water exit pathway; other site 1155777011543 Binuclear center (heme o3/CuB) [ion binding]; other site 1155777011544 K-pathway; other site 1155777011545 Putative proton exit pathway; other site 1155777011546 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1155777011547 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1155777011548 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1155777011549 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1155777011550 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1155777011551 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1155777011552 galactokinase; Provisional; Region: PRK05322 1155777011553 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1155777011554 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155777011555 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155777011556 Predicted membrane protein [Function unknown]; Region: COG2246 1155777011557 GtrA-like protein; Region: GtrA; pfam04138 1155777011558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777011559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777011560 Anti-repressor SinI; Region: SinI; pfam08671 1155777011561 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1155777011562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777011563 S-adenosylmethionine binding site [chemical binding]; other site 1155777011564 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1155777011565 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1155777011566 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1155777011567 catalytic residues [active] 1155777011568 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1155777011569 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1155777011570 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1155777011571 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1155777011572 thiamine phosphate binding site [chemical binding]; other site 1155777011573 active site 1155777011574 pyrophosphate binding site [ion binding]; other site 1155777011575 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1155777011576 substrate binding site [chemical binding]; other site 1155777011577 multimerization interface [polypeptide binding]; other site 1155777011578 ATP binding site [chemical binding]; other site 1155777011579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155777011580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155777011581 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1155777011582 putative dimerization interface [polypeptide binding]; other site 1155777011583 holin-like protein; Validated; Region: PRK01658 1155777011584 TIGR00659 family protein; Region: TIGR00659 1155777011585 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1155777011586 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1155777011587 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155777011588 DNA binding residues [nucleotide binding] 1155777011589 dimer interface [polypeptide binding]; other site 1155777011590 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1155777011591 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1155777011592 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1155777011593 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1155777011594 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1155777011595 putative RNA binding site [nucleotide binding]; other site 1155777011596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777011597 S-adenosylmethionine binding site [chemical binding]; other site 1155777011598 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777011599 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1155777011600 active site 1155777011601 metal binding site [ion binding]; metal-binding site 1155777011602 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155777011603 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1155777011604 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1155777011605 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1155777011606 active site 1155777011607 catalytic residues [active] 1155777011608 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1155777011609 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1155777011610 Ligand binding site; other site 1155777011611 metal-binding site 1155777011612 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777011613 MarR family; Region: MarR; pfam01047 1155777011614 MarR family; Region: MarR_2; cl17246 1155777011615 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1155777011616 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1155777011617 active site 1155777011618 HIGH motif; other site 1155777011619 dimer interface [polypeptide binding]; other site 1155777011620 KMSKS motif; other site 1155777011621 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155777011622 RNA binding surface [nucleotide binding]; other site 1155777011623 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155777011624 synthetase active site [active] 1155777011625 NTP binding site [chemical binding]; other site 1155777011626 metal binding site [ion binding]; metal-binding site 1155777011627 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1155777011628 UbiA prenyltransferase family; Region: UbiA; pfam01040 1155777011629 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1155777011630 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1155777011631 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1155777011632 acyl-activating enzyme (AAE) consensus motif; other site 1155777011633 AMP binding site [chemical binding]; other site 1155777011634 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1155777011635 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1155777011636 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1155777011637 DltD N-terminal region; Region: DltD_N; pfam04915 1155777011638 DltD central region; Region: DltD_M; pfam04918 1155777011639 DltD C-terminal region; Region: DltD_C; pfam04914 1155777011640 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1155777011641 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1155777011642 homodimer interface [polypeptide binding]; other site 1155777011643 substrate-cofactor binding pocket; other site 1155777011644 catalytic residue [active] 1155777011645 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1155777011646 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1155777011647 NAD binding site [chemical binding]; other site 1155777011648 sugar binding site [chemical binding]; other site 1155777011649 divalent metal binding site [ion binding]; other site 1155777011650 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155777011651 dimer interface [polypeptide binding]; other site 1155777011652 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155777011653 methionine cluster; other site 1155777011654 active site 1155777011655 phosphorylation site [posttranslational modification] 1155777011656 metal binding site [ion binding]; metal-binding site 1155777011657 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155777011658 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1155777011659 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1155777011660 active site 1155777011661 P-loop; other site 1155777011662 phosphorylation site [posttranslational modification] 1155777011663 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155777011664 HTH domain; Region: HTH_11; pfam08279 1155777011665 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155777011666 PRD domain; Region: PRD; pfam00874 1155777011667 PRD domain; Region: PRD; pfam00874 1155777011668 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155777011669 active site 1155777011670 P-loop; other site 1155777011671 phosphorylation site [posttranslational modification] 1155777011672 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155777011673 active site 1155777011674 phosphorylation site [posttranslational modification] 1155777011675 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1155777011676 active site 1155777011677 DNA binding site [nucleotide binding] 1155777011678 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1155777011679 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777011680 ABC-ATPase subunit interface; other site 1155777011681 dimer interface [polypeptide binding]; other site 1155777011682 putative PBP binding regions; other site 1155777011683 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155777011684 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155777011685 ABC-ATPase subunit interface; other site 1155777011686 dimer interface [polypeptide binding]; other site 1155777011687 putative PBP binding regions; other site 1155777011688 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155777011689 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1155777011690 intersubunit interface [polypeptide binding]; other site 1155777011691 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777011692 dimerization interface [polypeptide binding]; other site 1155777011693 putative DNA binding site [nucleotide binding]; other site 1155777011694 putative Zn2+ binding site [ion binding]; other site 1155777011695 arsenical pump membrane protein; Provisional; Region: PRK15445 1155777011696 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1155777011697 transmembrane helices; other site 1155777011698 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1155777011699 active site 1155777011700 P-loop; other site 1155777011701 phosphorylation site [posttranslational modification] 1155777011702 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155777011703 active site 1155777011704 methionine cluster; other site 1155777011705 phosphorylation site [posttranslational modification] 1155777011706 metal binding site [ion binding]; metal-binding site 1155777011707 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1155777011708 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1155777011709 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1155777011710 beta-galactosidase; Region: BGL; TIGR03356 1155777011711 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1155777011712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155777011713 nucleotide binding site [chemical binding]; other site 1155777011714 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1155777011715 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1155777011716 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1155777011717 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1155777011718 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1155777011719 tetramer interface [polypeptide binding]; other site 1155777011720 heme binding pocket [chemical binding]; other site 1155777011721 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1155777011722 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1155777011723 active site 1155777011724 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1155777011725 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1155777011726 Na binding site [ion binding]; other site 1155777011727 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1155777011728 putative substrate binding site [chemical binding]; other site 1155777011729 putative ATP binding site [chemical binding]; other site 1155777011730 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1155777011731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777011732 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1155777011733 Walker A/P-loop; other site 1155777011734 ATP binding site [chemical binding]; other site 1155777011735 Q-loop/lid; other site 1155777011736 ABC transporter signature motif; other site 1155777011737 Walker B; other site 1155777011738 D-loop; other site 1155777011739 H-loop/switch region; other site 1155777011740 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1155777011741 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777011742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777011743 ATP binding site [chemical binding]; other site 1155777011744 Q-loop/lid; other site 1155777011745 ABC transporter signature motif; other site 1155777011746 Walker B; other site 1155777011747 D-loop; other site 1155777011748 H-loop/switch region; other site 1155777011749 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1155777011750 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1155777011751 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1155777011752 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1155777011753 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1155777011754 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1155777011755 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1155777011756 putative active site [active] 1155777011757 putative metal binding site [ion binding]; other site 1155777011758 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1155777011759 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1155777011760 Walker A/P-loop; other site 1155777011761 ATP binding site [chemical binding]; other site 1155777011762 Q-loop/lid; other site 1155777011763 ABC transporter signature motif; other site 1155777011764 Walker B; other site 1155777011765 D-loop; other site 1155777011766 H-loop/switch region; other site 1155777011767 TOBE domain; Region: TOBE; pfam03459 1155777011768 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1155777011769 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1155777011770 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155777011771 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777011772 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155777011773 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1155777011774 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1155777011775 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1155777011776 UDP-glucose 4-epimerase; Region: PLN02240 1155777011777 NAD binding site [chemical binding]; other site 1155777011778 homodimer interface [polypeptide binding]; other site 1155777011779 active site 1155777011780 substrate binding site [chemical binding]; other site 1155777011781 peptidase T; Region: peptidase-T; TIGR01882 1155777011782 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1155777011783 metal binding site [ion binding]; metal-binding site 1155777011784 dimer interface [polypeptide binding]; other site 1155777011785 Tubby C 2; Region: Tub_2; cl02043 1155777011786 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1155777011787 substrate binding site [chemical binding]; other site 1155777011788 THF binding site; other site 1155777011789 zinc-binding site [ion binding]; other site 1155777011790 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1155777011791 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1155777011792 nucleoside transporter; Region: nupC; TIGR00804 1155777011793 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1155777011794 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1155777011795 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1155777011796 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1155777011797 hydroperoxidase II; Provisional; Region: katE; PRK11249 1155777011798 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1155777011799 tetramer interface [polypeptide binding]; other site 1155777011800 heme binding pocket [chemical binding]; other site 1155777011801 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1155777011802 domain interactions; other site 1155777011803 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1155777011804 Citrate transporter; Region: CitMHS; pfam03600 1155777011805 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1155777011806 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1155777011807 active site 1155777011808 active site 1155777011809 catalytic residues [active] 1155777011810 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1155777011811 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155777011812 PRD domain; Region: PRD; pfam00874 1155777011813 PRD domain; Region: PRD; pfam00874 1155777011814 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1155777011815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777011816 putative substrate translocation pore; other site 1155777011817 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1155777011818 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155777011819 ATP binding site [chemical binding]; other site 1155777011820 Mg++ binding site [ion binding]; other site 1155777011821 motif III; other site 1155777011822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777011823 nucleotide binding region [chemical binding]; other site 1155777011824 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1155777011825 RNA binding site [nucleotide binding]; other site 1155777011826 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1155777011827 YxiJ-like protein; Region: YxiJ; pfam14176 1155777011828 RHS Repeat; Region: RHS_repeat; pfam05593 1155777011829 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1155777011830 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1155777011831 RHS Repeat; Region: RHS_repeat; pfam05593 1155777011832 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1155777011833 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1155777011834 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1155777011835 Amb_all domain; Region: Amb_all; smart00656 1155777011836 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1155777011837 EamA-like transporter family; Region: EamA; pfam00892 1155777011838 EamA-like transporter family; Region: EamA; pfam00892 1155777011839 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155777011840 Ligand Binding Site [chemical binding]; other site 1155777011841 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 1155777011842 PLD-like domain; Region: PLDc_2; pfam13091 1155777011843 putative homodimer interface [polypeptide binding]; other site 1155777011844 putative active site [active] 1155777011845 catalytic site [active] 1155777011846 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155777011847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155777011848 ATP binding site [chemical binding]; other site 1155777011849 putative Mg++ binding site [ion binding]; other site 1155777011850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155777011851 nucleotide binding region [chemical binding]; other site 1155777011852 ATP-binding site [chemical binding]; other site 1155777011853 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1155777011854 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1155777011855 active site 1155777011856 8-oxo-dGMP binding site [chemical binding]; other site 1155777011857 nudix motif; other site 1155777011858 metal binding site [ion binding]; metal-binding site 1155777011859 AAA domain; Region: AAA_11; pfam13086 1155777011860 Part of AAA domain; Region: AAA_19; pfam13245 1155777011861 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1155777011862 AAA domain; Region: AAA_12; pfam13087 1155777011863 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1155777011864 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1155777011865 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1155777011866 substrate binding site [chemical binding]; other site 1155777011867 active site 1155777011868 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1155777011869 hexamer interface [polypeptide binding]; other site 1155777011870 RNA binding site [nucleotide binding]; other site 1155777011871 Histidine-zinc binding site [chemical binding]; other site 1155777011872 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1155777011873 active sites [active] 1155777011874 tetramer interface [polypeptide binding]; other site 1155777011875 urocanate hydratase; Provisional; Region: PRK05414 1155777011876 imidazolonepropionase; Validated; Region: PRK09356 1155777011877 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1155777011878 active site 1155777011879 Agmatinase-like family; Region: Agmatinase-like; cd09990 1155777011880 agmatinase; Region: agmatinase; TIGR01230 1155777011881 active site 1155777011882 oligomer interface [polypeptide binding]; other site 1155777011883 Mn binding site [ion binding]; other site 1155777011884 S-methylmethionine transporter; Provisional; Region: PRK11387 1155777011885 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1155777011886 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1155777011887 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1155777011888 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1155777011889 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1155777011890 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1155777011891 Nucleoside recognition; Region: Gate; pfam07670 1155777011892 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1155777011893 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1155777011894 intersubunit interface [polypeptide binding]; other site 1155777011895 active site 1155777011896 catalytic residue [active] 1155777011897 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1155777011898 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1155777011899 non-specific DNA interactions [nucleotide binding]; other site 1155777011900 DNA binding site [nucleotide binding] 1155777011901 sequence specific DNA binding site [nucleotide binding]; other site 1155777011902 putative cAMP binding site [chemical binding]; other site 1155777011903 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1155777011904 sugar phosphate phosphatase; Provisional; Region: PRK10513 1155777011905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777011906 active site 1155777011907 motif I; other site 1155777011908 motif II; other site 1155777011909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777011910 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1155777011911 SlyX; Region: SlyX; cl01090 1155777011912 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155777011913 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1155777011914 putative ligand binding residues [chemical binding]; other site 1155777011915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1155777011916 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155777011917 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155777011918 Walker A/P-loop; other site 1155777011919 ATP binding site [chemical binding]; other site 1155777011920 Q-loop/lid; other site 1155777011921 ABC transporter signature motif; other site 1155777011922 Walker B; other site 1155777011923 D-loop; other site 1155777011924 H-loop/switch region; other site 1155777011925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777011926 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1155777011927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777011928 ATP binding site [chemical binding]; other site 1155777011929 Mg2+ binding site [ion binding]; other site 1155777011930 G-X-G motif; other site 1155777011931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777011932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777011933 active site 1155777011934 phosphorylation site [posttranslational modification] 1155777011935 intermolecular recognition site; other site 1155777011936 dimerization interface [polypeptide binding]; other site 1155777011937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777011938 DNA binding site [nucleotide binding] 1155777011939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777011940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777011941 dimer interface [polypeptide binding]; other site 1155777011942 phosphorylation site [posttranslational modification] 1155777011943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777011944 ATP binding site [chemical binding]; other site 1155777011945 Mg2+ binding site [ion binding]; other site 1155777011946 G-X-G motif; other site 1155777011947 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777011948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777011949 active site 1155777011950 phosphorylation site [posttranslational modification] 1155777011951 intermolecular recognition site; other site 1155777011952 dimerization interface [polypeptide binding]; other site 1155777011953 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777011954 DNA binding site [nucleotide binding] 1155777011955 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155777011956 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1155777011957 Walker A/P-loop; other site 1155777011958 ATP binding site [chemical binding]; other site 1155777011959 Q-loop/lid; other site 1155777011960 ABC transporter signature motif; other site 1155777011961 Walker B; other site 1155777011962 D-loop; other site 1155777011963 H-loop/switch region; other site 1155777011964 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155777011965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1155777011966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1155777011967 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155777011968 Ycf27; Reviewed; Region: orf27; CHL00148 1155777011969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777011970 DNA binding site [nucleotide binding] 1155777011971 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1155777011972 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1155777011973 active site 1155777011974 zinc binding site [ion binding]; other site 1155777011975 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1155777011976 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 1155777011977 putative active site [active] 1155777011978 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155777011979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777011980 Walker A/P-loop; other site 1155777011981 ATP binding site [chemical binding]; other site 1155777011982 Q-loop/lid; other site 1155777011983 ABC transporter signature motif; other site 1155777011984 Walker B; other site 1155777011985 D-loop; other site 1155777011986 H-loop/switch region; other site 1155777011987 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1155777011988 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1155777011989 intersubunit interface [polypeptide binding]; other site 1155777011990 active site 1155777011991 zinc binding site [ion binding]; other site 1155777011992 Na+ binding site [ion binding]; other site 1155777011993 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1155777011994 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1155777011995 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1155777011996 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1155777011997 DNA interaction; other site 1155777011998 Metal-binding active site; metal-binding site 1155777011999 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155777012000 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155777012001 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155777012002 Glucuronate isomerase; Region: UxaC; cl00829 1155777012003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777012004 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777012005 putative substrate translocation pore; other site 1155777012006 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1155777012007 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1155777012008 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1155777012009 PYR/PP interface [polypeptide binding]; other site 1155777012010 dimer interface [polypeptide binding]; other site 1155777012011 TPP binding site [chemical binding]; other site 1155777012012 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155777012013 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1155777012014 TPP-binding site; other site 1155777012015 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155777012016 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1155777012017 substrate binding site [chemical binding]; other site 1155777012018 ATP binding site [chemical binding]; other site 1155777012019 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1155777012020 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1155777012021 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1155777012022 tetrameric interface [polypeptide binding]; other site 1155777012023 NAD binding site [chemical binding]; other site 1155777012024 catalytic residues [active] 1155777012025 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155777012026 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1155777012027 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155777012028 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155777012029 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155777012030 active site 1155777012031 catalytic tetrad [active] 1155777012032 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1155777012033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777012034 putative substrate translocation pore; other site 1155777012035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777012036 heat shock protein 90; Provisional; Region: PRK05218 1155777012037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777012038 ATP binding site [chemical binding]; other site 1155777012039 Mg2+ binding site [ion binding]; other site 1155777012040 G-X-G motif; other site 1155777012041 short chain dehydrogenase; Validated; Region: PRK08589 1155777012042 classical (c) SDRs; Region: SDR_c; cd05233 1155777012043 NAD(P) binding site [chemical binding]; other site 1155777012044 active site 1155777012045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155777012046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777012047 active site 1155777012048 phosphorylation site [posttranslational modification] 1155777012049 intermolecular recognition site; other site 1155777012050 dimerization interface [polypeptide binding]; other site 1155777012051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155777012052 DNA binding residues [nucleotide binding] 1155777012053 dimerization interface [polypeptide binding]; other site 1155777012054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155777012055 Histidine kinase; Region: HisKA_3; pfam07730 1155777012056 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1155777012057 ATP binding site [chemical binding]; other site 1155777012058 Mg2+ binding site [ion binding]; other site 1155777012059 G-X-G motif; other site 1155777012060 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1155777012061 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1155777012062 putative di-iron ligands [ion binding]; other site 1155777012063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777012064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777012065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155777012066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155777012067 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1155777012068 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1155777012069 NAD(P) binding site [chemical binding]; other site 1155777012070 catalytic residues [active] 1155777012071 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1155777012072 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1155777012073 Trp docking motif [polypeptide binding]; other site 1155777012074 active site 1155777012075 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777012076 putative DNA binding site [nucleotide binding]; other site 1155777012077 dimerization interface [polypeptide binding]; other site 1155777012078 putative Zn2+ binding site [ion binding]; other site 1155777012079 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155777012080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777012081 putative substrate translocation pore; other site 1155777012082 RDD family; Region: RDD; pfam06271 1155777012083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777012084 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1155777012085 active site 1155777012086 peroxiredoxin; Region: AhpC; TIGR03137 1155777012087 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1155777012088 dimer interface [polypeptide binding]; other site 1155777012089 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1155777012090 catalytic triad [active] 1155777012091 peroxidatic and resolving cysteines [active] 1155777012092 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1155777012093 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1155777012094 catalytic residue [active] 1155777012095 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1155777012096 catalytic residues [active] 1155777012097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155777012098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155777012099 Fic family protein [Function unknown]; Region: COG3177 1155777012100 Fic/DOC family; Region: Fic; pfam02661 1155777012101 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155777012102 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1155777012103 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1155777012104 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1155777012105 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1155777012106 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1155777012107 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1155777012108 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1155777012109 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1155777012110 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1155777012111 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1155777012112 Ligand binding site; other site 1155777012113 metal-binding site 1155777012114 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1155777012115 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1155777012116 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1155777012117 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1155777012118 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1155777012119 AAA domain; Region: AAA_12; pfam13087 1155777012120 Part of AAA domain; Region: AAA_19; pfam13245 1155777012121 FRG domain; Region: FRG; pfam08867 1155777012122 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1155777012123 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1155777012124 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1155777012125 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155777012126 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155777012127 active site 1155777012128 catalytic tetrad [active] 1155777012129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155777012130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777012131 Coenzyme A binding pocket [chemical binding]; other site 1155777012132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1155777012133 binding surface 1155777012134 TPR motif; other site 1155777012135 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777012136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1155777012137 Arginase family; Region: Arginase; cd09989 1155777012138 agmatinase; Region: agmatinase; TIGR01230 1155777012139 active site 1155777012140 Mn binding site [ion binding]; other site 1155777012141 oligomer interface [polypeptide binding]; other site 1155777012142 S-methylmethionine transporter; Provisional; Region: PRK11387 1155777012143 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1155777012144 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155777012145 inhibitor-cofactor binding pocket; inhibition site 1155777012146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777012147 catalytic residue [active] 1155777012148 PAS domain; Region: PAS_9; pfam13426 1155777012149 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1155777012150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155777012151 Walker A motif; other site 1155777012152 ATP binding site [chemical binding]; other site 1155777012153 Walker B motif; other site 1155777012154 arginine finger; other site 1155777012155 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1155777012156 Cupin-like domain; Region: Cupin_8; pfam13621 1155777012157 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155777012158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155777012159 Walker A/P-loop; other site 1155777012160 ATP binding site [chemical binding]; other site 1155777012161 Q-loop/lid; other site 1155777012162 ABC transporter signature motif; other site 1155777012163 Walker B; other site 1155777012164 D-loop; other site 1155777012165 H-loop/switch region; other site 1155777012166 ABC transporter; Region: ABC_tran_2; pfam12848 1155777012167 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155777012168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777012169 putative substrate translocation pore; other site 1155777012170 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155777012171 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1155777012172 hypothetical protein; Provisional; Region: PRK08328 1155777012173 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1155777012174 ATP binding site [chemical binding]; other site 1155777012175 substrate interface [chemical binding]; other site 1155777012176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155777012177 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777012178 dimerization interface [polypeptide binding]; other site 1155777012179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777012180 dimer interface [polypeptide binding]; other site 1155777012181 phosphorylation site [posttranslational modification] 1155777012182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777012183 ATP binding site [chemical binding]; other site 1155777012184 Mg2+ binding site [ion binding]; other site 1155777012185 G-X-G motif; other site 1155777012186 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777012187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777012188 active site 1155777012189 phosphorylation site [posttranslational modification] 1155777012190 intermolecular recognition site; other site 1155777012191 dimerization interface [polypeptide binding]; other site 1155777012192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777012193 DNA binding site [nucleotide binding] 1155777012194 Predicted membrane protein [Function unknown]; Region: COG3212 1155777012195 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155777012196 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155777012197 Predicted membrane protein [Function unknown]; Region: COG3212 1155777012198 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155777012199 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1155777012200 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1155777012201 protein binding site [polypeptide binding]; other site 1155777012202 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1155777012203 YycH protein; Region: YycI; cl02015 1155777012204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1155777012205 YycH protein; Region: YycH; pfam07435 1155777012206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1155777012207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155777012208 dimerization interface [polypeptide binding]; other site 1155777012209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155777012210 putative active site [active] 1155777012211 heme pocket [chemical binding]; other site 1155777012212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155777012213 dimer interface [polypeptide binding]; other site 1155777012214 phosphorylation site [posttranslational modification] 1155777012215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155777012216 ATP binding site [chemical binding]; other site 1155777012217 Mg2+ binding site [ion binding]; other site 1155777012218 G-X-G motif; other site 1155777012219 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155777012220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155777012221 active site 1155777012222 phosphorylation site [posttranslational modification] 1155777012223 intermolecular recognition site; other site 1155777012224 dimerization interface [polypeptide binding]; other site 1155777012225 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155777012226 DNA binding site [nucleotide binding] 1155777012227 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1155777012228 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1155777012229 GDP-binding site [chemical binding]; other site 1155777012230 ACT binding site; other site 1155777012231 IMP binding site; other site 1155777012232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777012233 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1155777012234 active site 1155777012235 replicative DNA helicase; Provisional; Region: PRK05748 1155777012236 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1155777012237 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1155777012238 Walker A motif; other site 1155777012239 ATP binding site [chemical binding]; other site 1155777012240 Walker B motif; other site 1155777012241 DNA binding loops [nucleotide binding] 1155777012242 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1155777012243 YycC-like protein; Region: YycC; pfam14174 1155777012244 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1155777012245 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1155777012246 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1155777012247 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155777012248 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1155777012249 Phosphotransferase enzyme family; Region: APH; pfam01636 1155777012250 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1155777012251 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1155777012252 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1155777012253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155777012254 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1155777012255 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1155777012256 active site 1155777012257 substrate binding site [chemical binding]; other site 1155777012258 ATP binding site [chemical binding]; other site 1155777012259 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1155777012260 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1155777012261 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1155777012262 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1155777012263 diguanylate cyclase; Region: GGDEF; smart00267 1155777012264 DHH family; Region: DHH; pfam01368 1155777012265 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1155777012266 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1155777012267 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155777012268 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155777012269 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1155777012270 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1155777012271 DHHA2 domain; Region: DHHA2; pfam02833 1155777012272 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1155777012273 EamA-like transporter family; Region: EamA; pfam00892 1155777012274 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1155777012275 active site 1155777012276 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1155777012277 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1155777012278 substrate binding [chemical binding]; other site 1155777012279 active site 1155777012280 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1155777012281 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1155777012282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777012283 DNA-binding site [nucleotide binding]; DNA binding site 1155777012284 FCD domain; Region: FCD; pfam07729 1155777012285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1155777012286 DinB superfamily; Region: DinB_2; pfam12867 1155777012287 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155777012288 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1155777012289 EamA-like transporter family; Region: EamA; pfam00892 1155777012290 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1155777012291 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1155777012292 dimer interface [polypeptide binding]; other site 1155777012293 FMN binding site [chemical binding]; other site 1155777012294 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777012295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155777012296 putative DNA binding site [nucleotide binding]; other site 1155777012297 putative Zn2+ binding site [ion binding]; other site 1155777012298 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777012299 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155777012300 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155777012301 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155777012302 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155777012303 MarR family; Region: MarR; pfam01047 1155777012304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777012305 Coenzyme A binding pocket [chemical binding]; other site 1155777012306 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1155777012307 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1155777012308 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1155777012309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155777012310 active site 1155777012311 motif I; other site 1155777012312 motif II; other site 1155777012313 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1155777012314 nudix motif; other site 1155777012315 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1155777012316 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1155777012317 active site 1155777012318 catalytic residues [active] 1155777012319 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155777012320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155777012321 DNA-binding site [nucleotide binding]; DNA binding site 1155777012322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155777012323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155777012324 homodimer interface [polypeptide binding]; other site 1155777012325 catalytic residue [active] 1155777012326 EamA-like transporter family; Region: EamA; pfam00892 1155777012327 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1155777012328 EamA-like transporter family; Region: EamA; pfam00892 1155777012329 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1155777012330 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1155777012331 catalytic residues [active] 1155777012332 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1155777012333 CAAX protease self-immunity; Region: Abi; pfam02517 1155777012334 benzoate transport; Region: 2A0115; TIGR00895 1155777012335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777012336 putative substrate translocation pore; other site 1155777012337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155777012338 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1155777012339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155777012340 putative metal binding site [ion binding]; other site 1155777012341 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155777012342 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155777012343 DNA binding site [nucleotide binding] 1155777012344 domain linker motif; other site 1155777012345 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1155777012346 putative dimerization interface [polypeptide binding]; other site 1155777012347 putative ligand binding site [chemical binding]; other site 1155777012348 similar to exodeoxyribonuclease III, partial 1155777012349 similar to exodeoxyribonuclease III, partial 1155777012350 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1155777012351 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1155777012352 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1155777012353 DNA binding site [nucleotide binding] 1155777012354 active site 1155777012355 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1155777012356 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1155777012357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777012358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155777012359 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1155777012360 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155777012361 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155777012362 dimer interface [polypeptide binding]; other site 1155777012363 ssDNA binding site [nucleotide binding]; other site 1155777012364 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155777012365 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1155777012366 GTP-binding protein YchF; Reviewed; Region: PRK09601 1155777012367 YchF GTPase; Region: YchF; cd01900 1155777012368 G1 box; other site 1155777012369 GTP/Mg2+ binding site [chemical binding]; other site 1155777012370 Switch I region; other site 1155777012371 G2 box; other site 1155777012372 Switch II region; other site 1155777012373 G3 box; other site 1155777012374 G4 box; other site 1155777012375 G5 box; other site 1155777012376 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1155777012377 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1155777012378 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1155777012379 putative [4Fe-4S] binding site [ion binding]; other site 1155777012380 putative molybdopterin cofactor binding site [chemical binding]; other site 1155777012381 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1155777012382 molybdopterin cofactor binding site; other site 1155777012383 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1155777012384 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1155777012385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155777012386 Coenzyme A binding pocket [chemical binding]; other site 1155777012387 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1155777012388 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1155777012389 ParB-like nuclease domain; Region: ParB; smart00470 1155777012390 KorB domain; Region: KorB; pfam08535 1155777012391 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1155777012392 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1155777012393 P-loop; other site 1155777012394 Magnesium ion binding site [ion binding]; other site 1155777012395 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1155777012396 Magnesium ion binding site [ion binding]; other site 1155777012397 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155777012398 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1155777012399 ParB-like nuclease domain; Region: ParB; smart00470 1155777012400 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1155777012401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155777012402 S-adenosylmethionine binding site [chemical binding]; other site 1155777012403 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1155777012404 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1155777012405 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1155777012406 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1155777012407 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1155777012408 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1155777012409 G1 box; other site 1155777012410 GTP/Mg2+ binding site [chemical binding]; other site 1155777012411 Switch I region; other site 1155777012412 G2 box; other site 1155777012413 Switch II region; other site 1155777012414 G3 box; other site 1155777012415 G4 box; other site 1155777012416 G5 box; other site 1155777012417 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1155777012418 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1155777012419 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1155777012420 G-X-X-G motif; other site 1155777012421 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1155777012422 RxxxH motif; other site 1155777012423 OxaA-like protein precursor; Validated; Region: PRK02944 1155777012424 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1155777012425 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1155777012426 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399