-- dump date 20120504_133755 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1114958000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1114958000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1114958000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000004 Walker A motif; other site 1114958000005 ATP binding site [chemical binding]; other site 1114958000006 Walker B motif; other site 1114958000007 arginine finger; other site 1114958000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1114958000009 DnaA box-binding interface [nucleotide binding]; other site 1114958000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1114958000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1114958000012 putative DNA binding surface [nucleotide binding]; other site 1114958000013 dimer interface [polypeptide binding]; other site 1114958000014 beta-clamp/clamp loader binding surface; other site 1114958000015 beta-clamp/translesion DNA polymerase binding surface; other site 1114958000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1114958000017 recombination protein F; Reviewed; Region: recF; PRK00064 1114958000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 1114958000019 Walker A/P-loop; other site 1114958000020 ATP binding site [chemical binding]; other site 1114958000021 Q-loop/lid; other site 1114958000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958000023 ABC transporter signature motif; other site 1114958000024 Walker B; other site 1114958000025 D-loop; other site 1114958000026 H-loop/switch region; other site 1114958000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1114958000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958000029 ATP binding site [chemical binding]; other site 1114958000030 Mg2+ binding site [ion binding]; other site 1114958000031 G-X-G motif; other site 1114958000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114958000033 anchoring element; other site 1114958000034 dimer interface [polypeptide binding]; other site 1114958000035 ATP binding site [chemical binding]; other site 1114958000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1114958000037 active site 1114958000038 putative metal-binding site [ion binding]; other site 1114958000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114958000040 DNA gyrase subunit A; Validated; Region: PRK05560 1114958000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1114958000042 CAP-like domain; other site 1114958000043 active site 1114958000044 primary dimer interface [polypeptide binding]; other site 1114958000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000051 YaaC-like Protein; Region: YaaC; pfam14175 1114958000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1114958000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1114958000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 1114958000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1114958000056 active site 1114958000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1114958000058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1114958000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1114958000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1114958000062 active site 1114958000063 multimer interface [polypeptide binding]; other site 1114958000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1114958000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1114958000066 predicted active site [active] 1114958000067 catalytic triad [active] 1114958000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 1114958000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1114958000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1114958000071 dimer interface [polypeptide binding]; other site 1114958000072 active site 1114958000073 motif 1; other site 1114958000074 motif 2; other site 1114958000075 motif 3; other site 1114958000076 Glycerate kinase family; Region: Gly_kinase; cl00841 1114958000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1114958000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1114958000079 Substrate-binding site [chemical binding]; other site 1114958000080 Substrate specificity [chemical binding]; other site 1114958000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1114958000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1114958000083 Substrate-binding site [chemical binding]; other site 1114958000084 Substrate specificity [chemical binding]; other site 1114958000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1114958000086 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958000087 putative peptidoglycan binding site; other site 1114958000088 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958000089 putative peptidoglycan binding site; other site 1114958000090 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1114958000091 active site 1114958000092 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958000093 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1114958000094 catalytic triad [active] 1114958000095 conserved cis-peptide bond; other site 1114958000096 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1114958000097 nucleoside/Zn binding site; other site 1114958000098 dimer interface [polypeptide binding]; other site 1114958000099 catalytic motif [active] 1114958000100 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1114958000101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000102 Walker A motif; other site 1114958000103 ATP binding site [chemical binding]; other site 1114958000104 Walker B motif; other site 1114958000105 arginine finger; other site 1114958000106 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1114958000107 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1114958000108 recombination protein RecR; Reviewed; Region: recR; PRK00076 1114958000109 RecR protein; Region: RecR; pfam02132 1114958000110 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1114958000111 putative active site [active] 1114958000112 putative metal-binding site [ion binding]; other site 1114958000113 tetramer interface [polypeptide binding]; other site 1114958000114 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1114958000115 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 1114958000116 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1114958000117 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1114958000118 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1114958000119 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1114958000120 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1114958000121 homodimer interface [polypeptide binding]; other site 1114958000122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958000123 catalytic residue [active] 1114958000124 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1114958000125 thymidylate kinase; Validated; Region: tmk; PRK00698 1114958000126 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1114958000127 TMP-binding site; other site 1114958000128 ATP-binding site [chemical binding]; other site 1114958000129 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1114958000130 Protein of unknown function (DUF327); Region: DUF327; cl00753 1114958000131 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1114958000132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958000133 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1114958000134 TSC-22/dip/bun family; Region: TSC22; cl01853 1114958000135 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1114958000136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958000137 S-adenosylmethionine binding site [chemical binding]; other site 1114958000138 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1114958000139 GIY-YIG motif/motif A; other site 1114958000140 putative active site [active] 1114958000141 putative metal binding site [ion binding]; other site 1114958000142 Predicted methyltransferases [General function prediction only]; Region: COG0313 1114958000143 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114958000144 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1114958000145 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1114958000146 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1114958000147 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1114958000148 active site 1114958000149 HIGH motif; other site 1114958000150 KMSKS motif; other site 1114958000151 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1114958000152 tRNA binding surface [nucleotide binding]; other site 1114958000153 anticodon binding site; other site 1114958000154 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1114958000155 dimer interface [polypeptide binding]; other site 1114958000156 putative tRNA-binding site [nucleotide binding]; other site 1114958000157 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114958000158 active site 1114958000159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1114958000160 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114958000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114958000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114958000163 G5 domain; Region: G5; pfam07501 1114958000164 3D domain; Region: 3D; cl01439 1114958000165 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1114958000166 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1114958000167 putative active site [active] 1114958000168 putative metal binding site [ion binding]; other site 1114958000169 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1114958000170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958000171 S-adenosylmethionine binding site [chemical binding]; other site 1114958000172 YabG peptidase U57; Region: Peptidase_U57; cl05250 1114958000173 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 1114958000174 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1114958000175 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1114958000176 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1114958000177 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1114958000178 pur operon repressor; Provisional; Region: PRK09213 1114958000179 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1114958000180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958000181 active site 1114958000182 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114958000183 homotrimer interaction site [polypeptide binding]; other site 1114958000184 putative active site [active] 1114958000185 SpoVG; Region: SpoVG; cl00915 1114958000186 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1114958000187 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1114958000188 Substrate binding site; other site 1114958000189 Mg++ binding site; other site 1114958000190 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1114958000191 active site 1114958000192 substrate binding site [chemical binding]; other site 1114958000193 CoA binding site [chemical binding]; other site 1114958000194 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1114958000195 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1114958000196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958000197 active site 1114958000198 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1114958000199 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1114958000200 5S rRNA interface [nucleotide binding]; other site 1114958000201 CTC domain interface [polypeptide binding]; other site 1114958000202 L16 interface [polypeptide binding]; other site 1114958000203 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1114958000204 putative active site [active] 1114958000205 catalytic residue [active] 1114958000206 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1114958000207 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1114958000208 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1114958000209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958000210 ATP binding site [chemical binding]; other site 1114958000211 putative Mg++ binding site [ion binding]; other site 1114958000212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958000213 nucleotide binding region [chemical binding]; other site 1114958000214 ATP-binding site [chemical binding]; other site 1114958000215 TRCF domain; Region: TRCF; cl04088 1114958000216 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1114958000217 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1114958000218 MatE; Region: MatE; cl10513 1114958000219 MatE; Region: MatE; cl10513 1114958000220 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1114958000221 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114958000222 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1114958000223 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958000224 RNA binding surface [nucleotide binding]; other site 1114958000225 YabP family; Region: YabP; cl06766 1114958000226 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 1114958000227 Septum formation initiator; Region: DivIC; cl11433 1114958000228 hypothetical protein; Provisional; Region: PRK08582 1114958000229 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1114958000230 RNA binding site [nucleotide binding]; other site 1114958000231 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1114958000232 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1114958000233 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114958000234 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1114958000235 metal ion-dependent adhesion site (MIDAS); other site 1114958000236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958000237 active site 1114958000238 ATP binding site [chemical binding]; other site 1114958000239 substrate binding site [chemical binding]; other site 1114958000240 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1114958000241 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1114958000242 Ligand Binding Site [chemical binding]; other site 1114958000243 B3/4 domain; Region: B3_4; cl11458 1114958000244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958000245 active site 1114958000246 FtsH Extracellular; Region: FtsH_ext; pfam06480 1114958000247 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1114958000248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000249 Walker A motif; other site 1114958000250 ATP binding site [chemical binding]; other site 1114958000251 Walker B motif; other site 1114958000252 arginine finger; other site 1114958000253 Peptidase family M41; Region: Peptidase_M41; pfam01434 1114958000254 Type III pantothenate kinase; Region: Pan_kinase; cl09130 1114958000255 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1114958000256 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1114958000257 dimerization interface [polypeptide binding]; other site 1114958000258 domain crossover interface; other site 1114958000259 redox-dependent activation switch; other site 1114958000260 SurA N-terminal domain; Region: SurA_N_3; cl07813 1114958000261 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114958000262 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114958000263 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114958000264 dimer interface [polypeptide binding]; other site 1114958000265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958000266 catalytic residue [active] 1114958000267 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114958000268 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114958000269 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114958000270 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1114958000271 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114958000272 glutamine binding [chemical binding]; other site 1114958000273 catalytic triad [active] 1114958000274 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1114958000275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958000276 catalytic residue [active] 1114958000277 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1114958000278 dihydropteroate synthase; Region: DHPS; TIGR01496 1114958000279 substrate binding pocket [chemical binding]; other site 1114958000280 dimer interface [polypeptide binding]; other site 1114958000281 inhibitor binding site; inhibition site 1114958000282 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1114958000283 homooctamer interface [polypeptide binding]; other site 1114958000284 active site 1114958000285 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1114958000286 catalytic center binding site [active] 1114958000287 ATP binding site [chemical binding]; other site 1114958000288 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1114958000289 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114958000290 FMN binding site [chemical binding]; other site 1114958000291 active site 1114958000292 catalytic residues [active] 1114958000293 substrate binding site [chemical binding]; other site 1114958000294 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1114958000295 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1114958000296 dimer interface [polypeptide binding]; other site 1114958000297 putative anticodon binding site; other site 1114958000298 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1114958000299 motif 1; other site 1114958000300 active site 1114958000301 motif 2; other site 1114958000302 motif 3; other site 1114958000303 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 1114958000304 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1114958000305 UvrB/uvrC motif; Region: UVR; pfam02151 1114958000306 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1114958000307 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1114958000308 ADP binding site [chemical binding]; other site 1114958000309 phosphagen binding site; other site 1114958000310 substrate specificity loop; other site 1114958000311 Clp protease ATP binding subunit; Region: clpC; CHL00095 1114958000312 Clp amino terminal domain; Region: Clp_N; pfam02861 1114958000313 Clp amino terminal domain; Region: Clp_N; pfam02861 1114958000314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000315 Walker A motif; other site 1114958000316 ATP binding site [chemical binding]; other site 1114958000317 Walker B motif; other site 1114958000318 arginine finger; other site 1114958000319 UvrB/uvrC motif; Region: UVR; pfam02151 1114958000320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000321 Walker A motif; other site 1114958000322 ATP binding site [chemical binding]; other site 1114958000323 Walker B motif; other site 1114958000324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114958000325 DNA repair protein RadA; Provisional; Region: PRK11823 1114958000326 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1114958000327 Walker A motif/ATP binding site; other site 1114958000328 ATP binding site [chemical binding]; other site 1114958000329 Walker B motif; other site 1114958000330 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114958000331 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1114958000332 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1114958000333 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1114958000334 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1114958000335 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1114958000336 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1114958000337 putative active site [active] 1114958000338 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1114958000339 substrate binding site; other site 1114958000340 dimer interface; other site 1114958000341 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1114958000342 homotrimer interaction site [polypeptide binding]; other site 1114958000343 zinc binding site [ion binding]; other site 1114958000344 CDP-binding sites; other site 1114958000345 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1114958000346 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114958000347 HIGH motif; other site 1114958000348 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114958000349 active site 1114958000350 KMSKS motif; other site 1114958000351 serine O-acetyltransferase; Region: cysE; TIGR01172 1114958000352 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1114958000353 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1114958000354 trimer interface [polypeptide binding]; other site 1114958000355 active site 1114958000356 substrate binding site [chemical binding]; other site 1114958000357 CoA binding site [chemical binding]; other site 1114958000358 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1114958000359 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114958000360 active site 1114958000361 HIGH motif; other site 1114958000362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114958000363 KMSKS motif; other site 1114958000364 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114958000365 tRNA binding surface [nucleotide binding]; other site 1114958000366 anticodon binding site; other site 1114958000367 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1114958000368 active site 1114958000369 metal binding site [ion binding]; metal-binding site 1114958000370 dimerization interface [polypeptide binding]; other site 1114958000371 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1114958000372 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1114958000373 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1114958000374 YacP-like NYN domain; Region: NYN_YacP; cl01491 1114958000375 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1114958000376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958000377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958000378 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1114958000379 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1114958000380 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1114958000381 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1114958000382 putative homodimer interface [polypeptide binding]; other site 1114958000383 KOW motif; Region: KOW; cl00354 1114958000384 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1114958000385 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1114958000386 23S rRNA interface [nucleotide binding]; other site 1114958000387 L7/L12 interface [polypeptide binding]; other site 1114958000388 putative thiostrepton binding site; other site 1114958000389 L25 interface [polypeptide binding]; other site 1114958000390 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1114958000391 mRNA/rRNA interface [nucleotide binding]; other site 1114958000392 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1114958000393 23S rRNA interface [nucleotide binding]; other site 1114958000394 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1114958000395 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1114958000396 core dimer interface [polypeptide binding]; other site 1114958000397 peripheral dimer interface [polypeptide binding]; other site 1114958000398 L10 interface [polypeptide binding]; other site 1114958000399 L11 interface [polypeptide binding]; other site 1114958000400 putative EF-Tu interaction site [polypeptide binding]; other site 1114958000401 putative EF-G interaction site [polypeptide binding]; other site 1114958000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958000403 S-adenosylmethionine binding site [chemical binding]; other site 1114958000404 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1114958000405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1114958000406 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1114958000407 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1114958000408 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1114958000409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1114958000410 RPB1 interaction site [polypeptide binding]; other site 1114958000411 RPB10 interaction site [polypeptide binding]; other site 1114958000412 RPB11 interaction site [polypeptide binding]; other site 1114958000413 RPB3 interaction site [polypeptide binding]; other site 1114958000414 RPB12 interaction site [polypeptide binding]; other site 1114958000415 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1114958000416 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1114958000417 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1114958000418 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1114958000419 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1114958000420 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1114958000421 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1114958000422 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1114958000423 G-loop; other site 1114958000424 DNA binding site [nucleotide binding] 1114958000425 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1114958000426 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1114958000427 S17 interaction site [polypeptide binding]; other site 1114958000428 S8 interaction site; other site 1114958000429 16S rRNA interaction site [nucleotide binding]; other site 1114958000430 streptomycin interaction site [chemical binding]; other site 1114958000431 23S rRNA interaction site [nucleotide binding]; other site 1114958000432 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1114958000433 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1114958000434 elongation factor G; Reviewed; Region: PRK00007 1114958000435 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1114958000436 G1 box; other site 1114958000437 putative GEF interaction site [polypeptide binding]; other site 1114958000438 GTP/Mg2+ binding site [chemical binding]; other site 1114958000439 Switch I region; other site 1114958000440 G2 box; other site 1114958000441 G3 box; other site 1114958000442 Switch II region; other site 1114958000443 G4 box; other site 1114958000444 G5 box; other site 1114958000445 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1114958000446 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1114958000447 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1114958000448 elongation factor Tu; Reviewed; Region: PRK00049 1114958000449 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1114958000450 G1 box; other site 1114958000451 GEF interaction site [polypeptide binding]; other site 1114958000452 GTP/Mg2+ binding site [chemical binding]; other site 1114958000453 Switch I region; other site 1114958000454 G2 box; other site 1114958000455 G3 box; other site 1114958000456 Switch II region; other site 1114958000457 G4 box; other site 1114958000458 G5 box; other site 1114958000459 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1114958000460 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1114958000461 Antibiotic Binding Site [chemical binding]; other site 1114958000462 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958000463 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1114958000464 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1114958000465 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1114958000466 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1114958000467 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1114958000468 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1114958000469 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1114958000470 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1114958000471 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1114958000472 putative translocon binding site; other site 1114958000473 protein-rRNA interface [nucleotide binding]; other site 1114958000474 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1114958000475 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1114958000476 G-X-X-G motif; other site 1114958000477 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1114958000478 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1114958000479 23S rRNA interface [nucleotide binding]; other site 1114958000480 5S rRNA interface [nucleotide binding]; other site 1114958000481 putative antibiotic binding site [chemical binding]; other site 1114958000482 L25 interface [polypeptide binding]; other site 1114958000483 L27 interface [polypeptide binding]; other site 1114958000484 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1114958000485 23S rRNA interface [nucleotide binding]; other site 1114958000486 putative translocon interaction site; other site 1114958000487 signal recognition particle (SRP54) interaction site; other site 1114958000488 L23 interface [polypeptide binding]; other site 1114958000489 trigger factor interaction site; other site 1114958000490 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1114958000491 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1114958000492 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1114958000493 KOW motif; Region: KOW; cl00354 1114958000494 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1114958000495 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1114958000496 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1114958000497 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1114958000498 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1114958000499 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1114958000500 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114958000501 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114958000502 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1114958000503 5S rRNA interface [nucleotide binding]; other site 1114958000504 L27 interface [polypeptide binding]; other site 1114958000505 23S rRNA interface [nucleotide binding]; other site 1114958000506 L5 interface [polypeptide binding]; other site 1114958000507 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1114958000508 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1114958000509 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1114958000510 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1114958000511 23S rRNA binding site [nucleotide binding]; other site 1114958000512 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1114958000513 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1114958000514 SecY translocase; Region: SecY; pfam00344 1114958000515 adenylate kinase; Reviewed; Region: adk; PRK00279 1114958000516 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1114958000517 AMP-binding site [chemical binding]; other site 1114958000518 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1114958000519 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114958000520 active site 1114958000521 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1114958000522 rRNA binding site [nucleotide binding]; other site 1114958000523 predicted 30S ribosome binding site; other site 1114958000524 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1114958000525 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1114958000526 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1114958000527 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 1114958000528 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1114958000529 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1114958000530 alphaNTD homodimer interface [polypeptide binding]; other site 1114958000531 alphaNTD - beta interaction site [polypeptide binding]; other site 1114958000532 alphaNTD - beta' interaction site [polypeptide binding]; other site 1114958000533 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1114958000534 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1114958000535 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1114958000536 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958000537 Walker A/P-loop; other site 1114958000538 ATP binding site [chemical binding]; other site 1114958000539 Q-loop/lid; other site 1114958000540 ABC transporter signature motif; other site 1114958000541 Walker B; other site 1114958000542 D-loop; other site 1114958000543 H-loop/switch region; other site 1114958000544 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1114958000545 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958000546 Walker A/P-loop; other site 1114958000547 ATP binding site [chemical binding]; other site 1114958000548 Q-loop/lid; other site 1114958000549 ABC transporter signature motif; other site 1114958000550 Walker B; other site 1114958000551 D-loop; other site 1114958000552 H-loop/switch region; other site 1114958000553 Cobalt transport protein; Region: CbiQ; cl00463 1114958000554 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1114958000555 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1114958000556 dimerization interface 3.5A [polypeptide binding]; other site 1114958000557 active site 1114958000558 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1114958000559 23S rRNA interface [nucleotide binding]; other site 1114958000560 L3 interface [polypeptide binding]; other site 1114958000561 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1114958000562 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114958000563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958000564 S-adenosylmethionine binding site [chemical binding]; other site 1114958000565 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114958000566 DinB superfamily; Region: DinB_2; pfam12867 1114958000567 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1114958000568 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958000569 active site 1114958000570 metal binding site [ion binding]; metal-binding site 1114958000571 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1114958000572 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1114958000573 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114958000574 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1114958000575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000576 putative substrate translocation pore; other site 1114958000577 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1114958000578 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958000579 inhibitor-cofactor binding pocket; inhibition site 1114958000580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958000581 catalytic residue [active] 1114958000582 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1114958000583 active site 1114958000584 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958000585 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958000586 NAD(P) binding site [chemical binding]; other site 1114958000587 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114958000588 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114958000589 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114958000590 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114958000591 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114958000592 Membrane transport protein; Region: Mem_trans; cl09117 1114958000593 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958000594 Putative esterase; Region: Esterase; pfam00756 1114958000595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958000596 ABC-ATPase subunit interface; other site 1114958000597 dimer interface [polypeptide binding]; other site 1114958000598 putative PBP binding regions; other site 1114958000599 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958000600 ABC-ATPase subunit interface; other site 1114958000601 dimer interface [polypeptide binding]; other site 1114958000602 putative PBP binding regions; other site 1114958000603 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114958000604 intersubunit interface [polypeptide binding]; other site 1114958000605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958000606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958000607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958000608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114958000609 intersubunit interface [polypeptide binding]; other site 1114958000610 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1114958000611 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1114958000612 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1114958000613 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1114958000614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958000615 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114958000616 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1114958000617 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958000618 active site turn [active] 1114958000619 phosphorylation site [posttranslational modification] 1114958000620 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958000621 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1114958000622 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1114958000623 putative active site [active] 1114958000624 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958000625 Protein of unknown function (DUF523); Region: DUF523; cl00733 1114958000626 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1114958000627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958000628 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958000629 DNA binding residues [nucleotide binding] 1114958000630 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1114958000631 Putative zinc-finger; Region: zf-HC2; cl15806 1114958000632 TIGR00159 family protein; Region: TIGR00159 1114958000633 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1114958000634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1114958000635 YbbR-like protein; Region: YbbR; pfam07949 1114958000636 YbbR-like protein; Region: YbbR; pfam07949 1114958000637 YbbR-like protein; Region: YbbR; pfam07949 1114958000638 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1114958000639 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1114958000640 active site 1114958000641 substrate binding site [chemical binding]; other site 1114958000642 metal binding site [ion binding]; metal-binding site 1114958000643 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1114958000644 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1114958000645 glutaminase active site [active] 1114958000646 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1114958000647 dimer interface [polypeptide binding]; other site 1114958000648 active site 1114958000649 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1114958000650 dimer interface [polypeptide binding]; other site 1114958000651 active site 1114958000652 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1114958000653 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114958000654 Walker A/P-loop; other site 1114958000655 ATP binding site [chemical binding]; other site 1114958000656 Q-loop/lid; other site 1114958000657 ABC transporter signature motif; other site 1114958000658 Walker B; other site 1114958000659 D-loop; other site 1114958000660 H-loop/switch region; other site 1114958000661 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1114958000662 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958000663 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958000664 active site 1114958000665 catalytic tetrad [active] 1114958000666 LrgB-like family; Region: LrgB; cl00596 1114958000667 LrgA family; Region: LrgA; cl00608 1114958000668 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958000669 Helix-turn-helix domains; Region: HTH; cl00088 1114958000670 putative transport protein YifK; Provisional; Region: PRK10746 1114958000671 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1114958000672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958000673 active site 1114958000674 motif I; other site 1114958000675 motif II; other site 1114958000676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114958000677 Histidine kinase; Region: HisKA_3; pfam07730 1114958000678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114958000679 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958000680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958000681 active site 1114958000682 phosphorylation site [posttranslational modification] 1114958000683 intermolecular recognition site; other site 1114958000684 dimerization interface [polypeptide binding]; other site 1114958000685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958000686 DNA binding residues [nucleotide binding] 1114958000687 dimerization interface [polypeptide binding]; other site 1114958000688 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958000689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958000690 Walker A/P-loop; other site 1114958000691 ATP binding site [chemical binding]; other site 1114958000692 Q-loop/lid; other site 1114958000693 ABC transporter signature motif; other site 1114958000694 Walker B; other site 1114958000695 D-loop; other site 1114958000696 H-loop/switch region; other site 1114958000697 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114958000698 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958000699 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114958000700 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958000701 Spore germination protein; Region: Spore_permease; cl15802 1114958000702 amino acid transporter; Region: 2A0306; TIGR00909 1114958000703 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1114958000704 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1114958000705 active site 1114958000706 catalytic site [active] 1114958000707 metal binding site [ion binding]; metal-binding site 1114958000708 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1114958000709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000710 putative substrate translocation pore; other site 1114958000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000712 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1114958000713 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1114958000714 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1114958000715 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958000716 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1114958000717 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958000718 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1114958000719 active site 1114958000720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958000721 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1114958000722 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1114958000723 active site 1114958000724 NAD binding site [chemical binding]; other site 1114958000725 metal binding site [ion binding]; metal-binding site 1114958000726 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1114958000727 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958000728 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958000729 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1114958000730 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114958000731 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1114958000732 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1114958000733 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1114958000734 active site residue [active] 1114958000735 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1114958000736 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114958000737 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114958000738 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1114958000739 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1114958000740 homodimer interface [polypeptide binding]; other site 1114958000741 substrate-cofactor binding pocket; other site 1114958000742 catalytic residue [active] 1114958000743 S-methylmethionine transporter; Provisional; Region: PRK11387 1114958000744 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1114958000745 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1114958000746 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1114958000747 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1114958000748 Glutaminase; Region: Glutaminase; cl00907 1114958000749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958000750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958000751 ATP binding site [chemical binding]; other site 1114958000752 Mg2+ binding site [ion binding]; other site 1114958000753 G-X-G motif; other site 1114958000754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958000755 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958000756 active site 1114958000757 phosphorylation site [posttranslational modification] 1114958000758 intermolecular recognition site; other site 1114958000759 dimerization interface [polypeptide binding]; other site 1114958000760 YcbB domain; Region: YcbB; pfam08664 1114958000761 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 1114958000762 putative active site [active] 1114958000763 putative substrate binding site [chemical binding]; other site 1114958000764 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958000765 ATP binding site [chemical binding]; other site 1114958000766 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1114958000767 dodecamer interface 1 [polypeptide binding]; other site 1114958000768 dodecamer interface 2 [polypeptide binding]; other site 1114958000769 trimer interface [polypeptide binding]; other site 1114958000770 TRAP binding interface [polypeptide binding]; other site 1114958000771 Zn binding site [ion binding]; other site 1114958000772 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114958000773 Cation efflux family; Region: Cation_efflux; cl00316 1114958000774 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1114958000775 dimer interface [polypeptide binding]; other site 1114958000776 FMN binding site [chemical binding]; other site 1114958000777 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1114958000778 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958000779 Zn binding site [ion binding]; other site 1114958000780 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1114958000781 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958000782 Zn binding site [ion binding]; other site 1114958000783 DoxX; Region: DoxX; cl00976 1114958000784 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958000785 catalytic residues [active] 1114958000786 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1114958000787 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1114958000788 PhoD-like phosphatase; Region: PhoD; pfam09423 1114958000789 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1114958000790 putative active site [active] 1114958000791 putative metal binding site [ion binding]; other site 1114958000792 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1114958000793 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1114958000794 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1114958000795 putative substrate binding pocket [chemical binding]; other site 1114958000796 AC domain interface; other site 1114958000797 catalytic triad [active] 1114958000798 AB domain interface; other site 1114958000799 interchain disulfide; other site 1114958000800 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114958000801 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958000802 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958000803 catalytic residue [active] 1114958000804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000805 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958000806 putative substrate translocation pore; other site 1114958000807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958000808 Helix-turn-helix domains; Region: HTH; cl00088 1114958000809 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1114958000810 active site 1114958000811 homotetramer interface [polypeptide binding]; other site 1114958000812 homodimer interface [polypeptide binding]; other site 1114958000813 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958000814 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1114958000815 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1114958000816 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114958000817 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958000818 active site 1114958000819 catalytic tetrad [active] 1114958000820 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1114958000821 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1114958000822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958000823 binding surface 1114958000824 TPR motif; other site 1114958000825 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1114958000826 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1114958000827 NAD binding site [chemical binding]; other site 1114958000828 homodimer interface [polypeptide binding]; other site 1114958000829 active site 1114958000830 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1114958000831 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1114958000832 Ca binding site [ion binding]; other site 1114958000833 active site 1114958000834 catalytic site [active] 1114958000835 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114958000836 Helix-turn-helix domains; Region: HTH; cl00088 1114958000837 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1114958000838 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1114958000839 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1114958000840 metal binding site [ion binding]; metal-binding site 1114958000841 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1114958000842 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1114958000843 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958000844 ABC-ATPase subunit interface; other site 1114958000845 dimer interface [polypeptide binding]; other site 1114958000846 putative PBP binding regions; other site 1114958000847 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1114958000848 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958000849 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958000850 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1114958000851 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1114958000852 putative metal binding site [ion binding]; other site 1114958000853 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1114958000854 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1114958000855 putative metal binding site [ion binding]; other site 1114958000856 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1114958000857 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1114958000858 putative metal binding site [ion binding]; other site 1114958000859 Integral membrane protein TerC family; Region: TerC; cl10468 1114958000860 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1114958000861 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1114958000862 benzoate transport; Region: 2A0115; TIGR00895 1114958000863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000864 putative substrate translocation pore; other site 1114958000865 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 1114958000866 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1114958000867 Walker A/P-loop; other site 1114958000868 ATP binding site [chemical binding]; other site 1114958000869 Q-loop/lid; other site 1114958000870 ABC transporter signature motif; other site 1114958000871 Walker B; other site 1114958000872 D-loop; other site 1114958000873 H-loop/switch region; other site 1114958000874 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1114958000875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958000876 dimer interface [polypeptide binding]; other site 1114958000877 conserved gate region; other site 1114958000878 putative PBP binding loops; other site 1114958000879 ABC-ATPase subunit interface; other site 1114958000880 NMT1-like family; Region: NMT1_2; cl15260 1114958000881 NMT1-like family; Region: NMT1_2; cl15260 1114958000882 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1114958000883 amidohydrolase; Region: amidohydrolases; TIGR01891 1114958000884 metal binding site [ion binding]; metal-binding site 1114958000885 putative dimer interface [polypeptide binding]; other site 1114958000886 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114958000887 oligosaccharyl transferase, archaeosortase system-associated; Region: archaeo_STT3; TIGR04154 1114958000888 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1114958000889 active site 1114958000890 Ca binding site [ion binding]; other site 1114958000891 catalytic site [active] 1114958000892 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1114958000893 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1114958000894 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1114958000895 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958000896 NAD binding site [chemical binding]; other site 1114958000897 dimer interface [polypeptide binding]; other site 1114958000898 substrate binding site [chemical binding]; other site 1114958000899 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114958000900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000901 putative substrate translocation pore; other site 1114958000902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000903 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958000904 Helix-turn-helix domains; Region: HTH; cl00088 1114958000905 LysE type translocator; Region: LysE; cl00565 1114958000906 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1114958000907 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114958000908 Spore germination protein; Region: Spore_permease; cl15802 1114958000909 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114958000910 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114958000911 NAD+ synthetase; Region: nadE; TIGR00552 1114958000912 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1114958000913 homodimer interface [polypeptide binding]; other site 1114958000914 NAD binding pocket [chemical binding]; other site 1114958000915 ATP binding pocket [chemical binding]; other site 1114958000916 Mg binding site [ion binding]; other site 1114958000917 active-site loop [active] 1114958000918 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1114958000919 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958000920 AAA domain; Region: AAA_18; pfam13238 1114958000921 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114958000922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000923 D-galactonate transporter; Region: 2A0114; TIGR00893 1114958000924 putative substrate translocation pore; other site 1114958000925 shikimate kinase; Reviewed; Region: aroK; PRK00131 1114958000926 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1114958000927 ADP binding site [chemical binding]; other site 1114958000928 magnesium binding site [ion binding]; other site 1114958000929 putative shikimate binding site; other site 1114958000930 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1114958000931 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1114958000932 Proline dehydrogenase; Region: Pro_dh; cl03282 1114958000933 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1114958000934 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1114958000935 Glutamate binding site [chemical binding]; other site 1114958000936 homodimer interface [polypeptide binding]; other site 1114958000937 NAD binding site [chemical binding]; other site 1114958000938 catalytic residues [active] 1114958000939 Sodium:solute symporter family; Region: SSF; cl00456 1114958000940 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1114958000941 Helix-turn-helix domains; Region: HTH; cl00088 1114958000942 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1114958000943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958000944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958000945 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1114958000946 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114958000947 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1114958000948 [2Fe-2S] cluster binding site [ion binding]; other site 1114958000949 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1114958000950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958000951 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114958000952 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1114958000953 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114958000954 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1114958000955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958000956 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1114958000957 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1114958000958 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958000959 NAD binding site [chemical binding]; other site 1114958000960 catalytic Zn binding site [ion binding]; other site 1114958000961 structural Zn binding site [ion binding]; other site 1114958000962 RDD family; Region: RDD; cl00746 1114958000963 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1114958000964 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1114958000965 Competence protein J (ComJ); Region: ComJ; pfam11033 1114958000966 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1114958000967 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1114958000968 tetramer interface [polypeptide binding]; other site 1114958000969 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 1114958000970 active site 1114958000971 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1114958000972 active site 1114958000973 dimer interface [polypeptide binding]; other site 1114958000974 magnesium binding site [ion binding]; other site 1114958000975 Helix-turn-helix domains; Region: HTH; cl00088 1114958000976 peptide synthase; Provisional; Region: PRK12316 1114958000977 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958000978 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958000979 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958000980 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958000981 peptide synthase; Provisional; Region: PRK12316 1114958000982 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958000983 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958000984 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958000985 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958000986 peptide synthase; Provisional; Region: PRK12316 1114958000987 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958000988 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958000989 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958000990 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958000991 peptide synthase; Provisional; Region: PRK12467 1114958000992 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958000993 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958000994 peptide synthase; Provisional; Region: PRK12467 1114958000995 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958000996 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958000997 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958000998 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958000999 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958001000 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958001001 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958001002 peptide synthase; Provisional; Region: PRK12467 1114958001003 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958001004 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958001005 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1114958001006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958001007 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114958001008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958001009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001010 homodimer interface [polypeptide binding]; other site 1114958001011 catalytic residue [active] 1114958001012 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1114958001013 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1114958001014 Predicted membrane protein [Function unknown]; Region: COG2364 1114958001015 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958001016 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958001017 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114958001018 Walker A/P-loop; other site 1114958001019 ATP binding site [chemical binding]; other site 1114958001020 Q-loop/lid; other site 1114958001021 ABC transporter signature motif; other site 1114958001022 Walker B; other site 1114958001023 D-loop; other site 1114958001024 H-loop/switch region; other site 1114958001025 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114958001026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958001027 dimer interface [polypeptide binding]; other site 1114958001028 conserved gate region; other site 1114958001029 putative PBP binding loops; other site 1114958001030 ABC-ATPase subunit interface; other site 1114958001031 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114958001032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958001033 substrate binding pocket [chemical binding]; other site 1114958001034 membrane-bound complex binding site; other site 1114958001035 hinge residues; other site 1114958001036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958001037 Helix-turn-helix domains; Region: HTH; cl00088 1114958001038 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958001039 dimerization interface [polypeptide binding]; other site 1114958001040 aromatic acid decarboxylase; Validated; Region: PRK05920 1114958001041 Flavoprotein; Region: Flavoprotein; cl08021 1114958001042 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1114958001043 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1114958001044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001045 putative substrate translocation pore; other site 1114958001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1114958001047 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114958001048 Right handed beta helix region; Region: Beta_helix; pfam13229 1114958001049 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1114958001050 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958001051 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1114958001052 Spore germination protein; Region: Spore_permease; cl15802 1114958001053 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1114958001054 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1114958001055 active site 1114958001056 non-prolyl cis peptide bond; other site 1114958001057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958001058 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958001059 Coenzyme A binding pocket [chemical binding]; other site 1114958001060 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114958001061 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958001062 substrate binding pocket [chemical binding]; other site 1114958001063 membrane-bound complex binding site; other site 1114958001064 hinge residues; other site 1114958001065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958001066 dimer interface [polypeptide binding]; other site 1114958001067 conserved gate region; other site 1114958001068 putative PBP binding loops; other site 1114958001069 ABC-ATPase subunit interface; other site 1114958001070 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958001071 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114958001072 Walker A/P-loop; other site 1114958001073 ATP binding site [chemical binding]; other site 1114958001074 Q-loop/lid; other site 1114958001075 ABC transporter signature motif; other site 1114958001076 Walker B; other site 1114958001077 D-loop; other site 1114958001078 H-loop/switch region; other site 1114958001079 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1114958001080 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1114958001081 metal binding site [ion binding]; metal-binding site 1114958001082 dimer interface [polypeptide binding]; other site 1114958001083 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1114958001084 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958001085 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114958001086 Walker A/P-loop; other site 1114958001087 ATP binding site [chemical binding]; other site 1114958001088 Q-loop/lid; other site 1114958001089 ABC transporter signature motif; other site 1114958001090 Walker B; other site 1114958001091 D-loop; other site 1114958001092 H-loop/switch region; other site 1114958001093 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114958001094 FtsX-like permease family; Region: FtsX; cl15850 1114958001095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958001096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958001097 active site 1114958001098 phosphorylation site [posttranslational modification] 1114958001099 intermolecular recognition site; other site 1114958001100 dimerization interface [polypeptide binding]; other site 1114958001101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958001102 DNA binding site [nucleotide binding] 1114958001103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958001104 dimerization interface [polypeptide binding]; other site 1114958001105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958001106 dimer interface [polypeptide binding]; other site 1114958001107 phosphorylation site [posttranslational modification] 1114958001108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001109 ATP binding site [chemical binding]; other site 1114958001110 Mg2+ binding site [ion binding]; other site 1114958001111 G-X-G motif; other site 1114958001112 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001113 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958001115 TPR motif; other site 1114958001116 binding surface 1114958001117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001118 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1114958001119 aspartate kinase; Reviewed; Region: PRK09034 1114958001120 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1114958001121 putative catalytic residues [active] 1114958001122 putative nucleotide binding site [chemical binding]; other site 1114958001123 putative aspartate binding site [chemical binding]; other site 1114958001124 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1114958001125 allosteric regulatory residue; other site 1114958001126 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1114958001127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958001128 ABC-ATPase subunit interface; other site 1114958001129 dimer interface [polypeptide binding]; other site 1114958001130 putative PBP binding regions; other site 1114958001131 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958001132 ABC-ATPase subunit interface; other site 1114958001133 dimer interface [polypeptide binding]; other site 1114958001134 putative PBP binding regions; other site 1114958001135 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1114958001136 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114958001137 Walker A/P-loop; other site 1114958001138 ATP binding site [chemical binding]; other site 1114958001139 Q-loop/lid; other site 1114958001140 ABC transporter signature motif; other site 1114958001141 Walker B; other site 1114958001142 D-loop; other site 1114958001143 H-loop/switch region; other site 1114958001144 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1114958001145 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1114958001146 putative ligand binding residues [chemical binding]; other site 1114958001147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958001149 putative substrate translocation pore; other site 1114958001150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958001152 Helix-turn-helix domains; Region: HTH; cl00088 1114958001153 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1114958001154 dimer interface [polypeptide binding]; other site 1114958001155 FMN binding site [chemical binding]; other site 1114958001156 NADPH bind site [chemical binding]; other site 1114958001157 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114958001158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958001159 dimerization interface [polypeptide binding]; other site 1114958001160 putative DNA binding site [nucleotide binding]; other site 1114958001161 putative Zn2+ binding site [ion binding]; other site 1114958001162 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958001163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001164 DNA-binding site [nucleotide binding]; DNA binding site 1114958001165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958001166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001167 homodimer interface [polypeptide binding]; other site 1114958001168 catalytic residue [active] 1114958001169 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1114958001170 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958001171 inhibitor-cofactor binding pocket; inhibition site 1114958001172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001173 catalytic residue [active] 1114958001174 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114958001175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114958001176 tetramerization interface [polypeptide binding]; other site 1114958001177 NAD(P) binding site [chemical binding]; other site 1114958001178 catalytic residues [active] 1114958001179 Sugar transport protein; Region: Sugar_transport; pfam06800 1114958001180 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1114958001181 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1114958001182 NAD binding site [chemical binding]; other site 1114958001183 homodimer interface [polypeptide binding]; other site 1114958001184 active site 1114958001185 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1114958001186 Bacterial Ig-like domain; Region: Big_5; cl01012 1114958001187 Copper resistance protein D; Region: CopD; cl00563 1114958001188 FixH; Region: FixH; cl01254 1114958001189 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958001190 Helix-turn-helix domains; Region: HTH; cl00088 1114958001191 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1114958001192 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958001193 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1114958001194 active site 1114958001195 P-loop; other site 1114958001196 phosphorylation site [posttranslational modification] 1114958001197 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958001198 active site 1114958001199 phosphorylation site [posttranslational modification] 1114958001200 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1114958001201 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1114958001202 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1114958001203 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1114958001204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958001205 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958001206 active site 1114958001207 motif I; other site 1114958001208 motif II; other site 1114958001209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958001210 LamB/YcsF family; Region: LamB_YcsF; cl00664 1114958001211 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1114958001212 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 1114958001213 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1114958001214 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1114958001215 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1114958001216 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114958001217 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114958001218 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1114958001219 active site 1114958001220 catalytic triad [active] 1114958001221 oxyanion hole [active] 1114958001222 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1114958001223 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114958001224 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1114958001225 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1114958001226 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958001227 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958001228 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958001229 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958001230 active site 1114958001231 catalytic tetrad [active] 1114958001232 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114958001233 Helix-turn-helix domains; Region: HTH; cl00088 1114958001234 Helix-turn-helix domains; Region: HTH; cl00088 1114958001235 PRD domain; Region: PRD; cl15445 1114958001236 PRD domain; Region: PRD; cl15445 1114958001237 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1114958001238 active site 1114958001239 P-loop; other site 1114958001240 phosphorylation site [posttranslational modification] 1114958001241 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1114958001242 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1114958001243 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958001244 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958001245 short chain dehydrogenase; Provisional; Region: PRK06701 1114958001246 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1114958001247 NAD binding site [chemical binding]; other site 1114958001248 metal binding site [ion binding]; metal-binding site 1114958001249 active site 1114958001250 Cupin domain; Region: Cupin_2; cl09118 1114958001251 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114958001252 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958001253 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1114958001254 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114958001255 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1114958001256 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1114958001257 Helix-turn-helix domains; Region: HTH; cl00088 1114958001258 DNA topoisomerase III; Provisional; Region: PRK07726 1114958001259 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1114958001260 active site 1114958001261 putative interdomain interaction site [polypeptide binding]; other site 1114958001262 putative metal-binding site [ion binding]; other site 1114958001263 putative nucleotide binding site [chemical binding]; other site 1114958001264 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114958001265 domain I; other site 1114958001266 DNA binding groove [nucleotide binding] 1114958001267 phosphate binding site [ion binding]; other site 1114958001268 domain II; other site 1114958001269 domain III; other site 1114958001270 nucleotide binding site [chemical binding]; other site 1114958001271 catalytic site [active] 1114958001272 domain IV; other site 1114958001273 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1114958001274 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1114958001275 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1114958001276 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114958001277 metal binding site [ion binding]; metal-binding site 1114958001278 active site 1114958001279 I-site; other site 1114958001280 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1114958001281 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1114958001282 NodB motif; other site 1114958001283 putative active site [active] 1114958001284 putative catalytic site [active] 1114958001285 putative Zn binding site [ion binding]; other site 1114958001286 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1114958001287 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1114958001288 DXD motif; other site 1114958001289 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1114958001290 Amino acid permease; Region: AA_permease_2; pfam13520 1114958001291 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1114958001292 nudix motif; other site 1114958001293 pyruvate oxidase; Provisional; Region: PRK08611 1114958001294 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1114958001295 PYR/PP interface [polypeptide binding]; other site 1114958001296 dimer interface [polypeptide binding]; other site 1114958001297 tetramer interface [polypeptide binding]; other site 1114958001298 TPP binding site [chemical binding]; other site 1114958001299 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114958001300 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1114958001301 TPP-binding site [chemical binding]; other site 1114958001302 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958001303 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1114958001304 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958001305 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1114958001306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001307 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001309 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 1114958001310 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1114958001311 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958001312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1114958001313 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114958001314 EcsC protein family; Region: EcsC; pfam12787 1114958001315 General stress protein [General function prediction only]; Region: GsiB; COG3729 1114958001316 Cupin domain; Region: Cupin_2; cl09118 1114958001317 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1114958001318 dimanganese center [ion binding]; other site 1114958001319 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114958001320 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1114958001321 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1114958001322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958001323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001324 ATP binding site [chemical binding]; other site 1114958001325 Mg2+ binding site [ion binding]; other site 1114958001326 G-X-G motif; other site 1114958001327 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1114958001328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958001329 active site 1114958001330 phosphorylation site [posttranslational modification] 1114958001331 intermolecular recognition site; other site 1114958001332 dimerization interface [polypeptide binding]; other site 1114958001333 Helix-turn-helix domains; Region: HTH; cl00088 1114958001334 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114958001335 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114958001336 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958001337 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1114958001338 Walker A/P-loop; other site 1114958001339 ATP binding site [chemical binding]; other site 1114958001340 Q-loop/lid; other site 1114958001341 ABC transporter signature motif; other site 1114958001342 Walker B; other site 1114958001343 D-loop; other site 1114958001344 H-loop/switch region; other site 1114958001345 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958001346 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1114958001347 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114958001348 active site 1114958001349 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1114958001350 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1114958001351 Cation efflux family; Region: Cation_efflux; cl00316 1114958001352 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958001353 catalytic residues [active] 1114958001354 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1114958001355 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1114958001356 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958001357 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114958001358 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1114958001359 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958001360 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958001361 helicase 45; Provisional; Region: PTZ00424 1114958001362 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114958001363 ATP binding site [chemical binding]; other site 1114958001364 Mg++ binding site [ion binding]; other site 1114958001365 motif III; other site 1114958001366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958001367 nucleotide binding region [chemical binding]; other site 1114958001368 ATP-binding site [chemical binding]; other site 1114958001369 Bacterial PH domain; Region: DUF304; cl01348 1114958001370 Predicted membrane protein [Function unknown]; Region: COG3428 1114958001371 Bacterial PH domain; Region: DUF304; cl01348 1114958001372 Bacterial PH domain; Region: DUF304; cl01348 1114958001373 Bacterial PH domain; Region: DUF304; cl01348 1114958001374 Rhomboid family; Region: Rhomboid; cl11446 1114958001375 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1114958001376 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1114958001377 alanine racemase; Region: alr; TIGR00492 1114958001378 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1114958001379 active site 1114958001380 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114958001381 dimer interface [polypeptide binding]; other site 1114958001382 substrate binding site [chemical binding]; other site 1114958001383 catalytic residues [active] 1114958001384 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1114958001385 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1114958001386 PemK-like protein; Region: PemK; cl00995 1114958001387 Rsbr N terminal; Region: Rsbr_N; pfam08678 1114958001388 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958001389 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958001390 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1114958001391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001392 ATP binding site [chemical binding]; other site 1114958001393 Mg2+ binding site [ion binding]; other site 1114958001394 G-X-G motif; other site 1114958001395 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1114958001396 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1114958001397 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1114958001398 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114958001399 anti sigma factor interaction site; other site 1114958001400 regulatory phosphorylation site [posttranslational modification]; other site 1114958001401 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1114958001402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001403 ATP binding site [chemical binding]; other site 1114958001404 Mg2+ binding site [ion binding]; other site 1114958001405 G-X-G motif; other site 1114958001406 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1114958001407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958001408 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958001409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958001410 DNA binding residues [nucleotide binding] 1114958001411 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1114958001412 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1114958001413 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1114958001414 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1114958001415 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1114958001416 RNA binding site [nucleotide binding]; other site 1114958001417 SprT homologues; Region: SprT; cl01182 1114958001418 hypothetical protein; Provisional; Region: PRK04351 1114958001419 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958001420 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958001421 proline/glycine betaine transporter; Provisional; Region: PRK10642 1114958001422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001423 putative substrate translocation pore; other site 1114958001424 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958001425 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114958001426 substrate binding pocket [chemical binding]; other site 1114958001427 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958001428 OsmC-like protein; Region: OsmC; cl00767 1114958001429 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114958001430 Helix-turn-helix domains; Region: HTH; cl00088 1114958001431 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1114958001432 putative active site [active] 1114958001433 putative catalytic site [active] 1114958001434 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958001435 Helix-turn-helix domains; Region: HTH; cl00088 1114958001436 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1114958001437 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114958001438 NAD binding site [chemical binding]; other site 1114958001439 substrate binding site [chemical binding]; other site 1114958001440 putative active site [active] 1114958001441 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114958001442 DNA-binding site [nucleotide binding]; DNA binding site 1114958001443 RNA-binding motif; other site 1114958001444 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1114958001445 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1114958001446 putative homodimer interface [polypeptide binding]; other site 1114958001447 putative homotetramer interface [polypeptide binding]; other site 1114958001448 putative metal binding site [ion binding]; other site 1114958001449 putative homodimer-homodimer interface [polypeptide binding]; other site 1114958001450 putative allosteric switch controlling residues; other site 1114958001451 DsrE/DsrF-like family; Region: DrsE; cl00672 1114958001452 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1114958001453 CPxP motif; other site 1114958001454 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114958001455 active site residue [active] 1114958001456 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1114958001457 active site residue [active] 1114958001458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958001459 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1114958001460 CPxP motif; other site 1114958001461 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114958001462 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114958001463 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114958001464 aspartate racemase; Region: asp_race; TIGR00035 1114958001465 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1114958001466 Helix-turn-helix domains; Region: HTH; cl00088 1114958001467 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1114958001468 active site 1114958001469 nucleophile elbow; other site 1114958001470 DinB superfamily; Region: DinB_2; pfam12867 1114958001471 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1114958001472 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1114958001473 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958001474 catalytic residue [active] 1114958001475 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114958001476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001477 DNA-binding site [nucleotide binding]; DNA binding site 1114958001478 FCD domain; Region: FCD; cl11656 1114958001479 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114958001480 homotrimer interaction site [polypeptide binding]; other site 1114958001481 putative active site [active] 1114958001482 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1114958001483 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 1114958001484 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1114958001485 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1114958001486 metal binding site [ion binding]; metal-binding site 1114958001487 putative dimer interface [polypeptide binding]; other site 1114958001488 Cupin domain; Region: Cupin_2; cl09118 1114958001489 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958001490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958001491 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1114958001492 allantoate amidohydrolase; Reviewed; Region: PRK12890 1114958001493 active site 1114958001494 metal binding site [ion binding]; metal-binding site 1114958001495 dimer interface [polypeptide binding]; other site 1114958001496 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958001497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001498 DNA-binding site [nucleotide binding]; DNA binding site 1114958001499 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958001500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001501 homodimer interface [polypeptide binding]; other site 1114958001502 catalytic residue [active] 1114958001503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001504 putative substrate translocation pore; other site 1114958001505 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1114958001506 nudix motif; other site 1114958001507 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114958001508 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958001509 Berberine and berberine like; Region: BBE; pfam08031 1114958001510 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114958001511 active site 1114958001512 Cation efflux family; Region: Cation_efflux; cl00316 1114958001513 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114958001514 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1114958001515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958001516 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1114958001517 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1114958001518 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114958001519 inhibitor site; inhibition site 1114958001520 active site 1114958001521 dimer interface [polypeptide binding]; other site 1114958001522 catalytic residue [active] 1114958001523 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 1114958001524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958001525 FeS/SAM binding site; other site 1114958001526 Membrane transport protein; Region: Mem_trans; cl09117 1114958001527 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114958001528 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1114958001529 putative NAD(P) binding site [chemical binding]; other site 1114958001530 putative substrate binding site [chemical binding]; other site 1114958001531 catalytic Zn binding site [ion binding]; other site 1114958001532 structural Zn binding site [ion binding]; other site 1114958001533 dimer interface [polypeptide binding]; other site 1114958001534 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114958001535 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1114958001536 DNA binding residues [nucleotide binding] 1114958001537 putative dimer interface [polypeptide binding]; other site 1114958001538 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1114958001539 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958001540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001541 DNA-binding site [nucleotide binding]; DNA binding site 1114958001542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958001543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001544 homodimer interface [polypeptide binding]; other site 1114958001545 catalytic residue [active] 1114958001546 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114958001547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958001549 Helix-turn-helix domains; Region: HTH; cl00088 1114958001550 Coat F domain; Region: Coat_F; cl15836 1114958001551 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1114958001552 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958001553 NAD binding site [chemical binding]; other site 1114958001554 catalytic Zn binding site [ion binding]; other site 1114958001555 structural Zn binding site [ion binding]; other site 1114958001556 Coat F domain; Region: Coat_F; cl15836 1114958001557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958001558 Histidine kinase; Region: HisKA_3; pfam07730 1114958001559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001560 ATP binding site [chemical binding]; other site 1114958001561 Mg2+ binding site [ion binding]; other site 1114958001562 G-X-G motif; other site 1114958001563 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958001564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958001565 active site 1114958001566 phosphorylation site [posttranslational modification] 1114958001567 intermolecular recognition site; other site 1114958001568 dimerization interface [polypeptide binding]; other site 1114958001569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958001570 DNA binding residues [nucleotide binding] 1114958001571 dimerization interface [polypeptide binding]; other site 1114958001572 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1114958001573 Ammonia monooxygenase; Region: AMO; cl03602 1114958001574 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1114958001575 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1114958001576 catalytic triad [active] 1114958001577 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958001578 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958001579 ABC transporter; Region: ABC_tran_2; pfam12848 1114958001580 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958001581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114958001582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958001583 Coenzyme A binding pocket [chemical binding]; other site 1114958001584 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958001585 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958001586 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958001587 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1114958001588 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1114958001589 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1114958001590 dimer interface [polypeptide binding]; other site 1114958001591 active site 1114958001592 metal binding site [ion binding]; metal-binding site 1114958001593 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1114958001594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001595 putative substrate translocation pore; other site 1114958001596 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1114958001597 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114958001598 dimer interface [polypeptide binding]; other site 1114958001599 active site 1114958001600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958001601 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114958001602 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958001603 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1114958001604 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114958001605 DNA binding residues [nucleotide binding] 1114958001606 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1114958001607 EamA-like transporter family; Region: EamA; cl01037 1114958001608 EamA-like transporter family; Region: EamA; cl01037 1114958001609 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1114958001610 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1114958001611 nudix motif; other site 1114958001612 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114958001613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958001614 S-adenosylmethionine binding site [chemical binding]; other site 1114958001615 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114958001616 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114958001617 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114958001618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001619 DNA-binding site [nucleotide binding]; DNA binding site 1114958001620 FCD domain; Region: FCD; cl11656 1114958001621 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1114958001622 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1114958001623 active site 1114958001624 TDP-binding site; other site 1114958001625 acceptor substrate-binding pocket; other site 1114958001626 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958001627 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1114958001628 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1114958001629 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1114958001630 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958001631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001632 putative substrate translocation pore; other site 1114958001633 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114958001634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001635 DNA-binding site [nucleotide binding]; DNA binding site 1114958001636 UTRA domain; Region: UTRA; cl01230 1114958001637 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114958001638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001639 DNA-binding site [nucleotide binding]; DNA binding site 1114958001640 FCD domain; Region: FCD; cl11656 1114958001641 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1114958001642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001643 putative substrate translocation pore; other site 1114958001644 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114958001645 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114958001646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958001647 Helix-turn-helix domains; Region: HTH; cl00088 1114958001648 amino acid transporter; Region: 2A0306; TIGR00909 1114958001649 Spore germination protein; Region: Spore_permease; cl15802 1114958001650 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1114958001651 dimanganese center [ion binding]; other site 1114958001652 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1114958001653 putative hydrophobic ligand binding site [chemical binding]; other site 1114958001654 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1114958001655 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1114958001656 putative NADP binding site [chemical binding]; other site 1114958001657 putative dimer interface [polypeptide binding]; other site 1114958001658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001659 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114958001660 putative substrate translocation pore; other site 1114958001661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001662 thiamine monophosphate kinase; Provisional; Region: PRK05731 1114958001663 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1114958001664 ATP binding site [chemical binding]; other site 1114958001665 dimerization interface [polypeptide binding]; other site 1114958001666 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1114958001667 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1114958001668 Glycoprotease family; Region: Peptidase_M22; pfam00814 1114958001669 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1114958001670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958001671 Coenzyme A binding pocket [chemical binding]; other site 1114958001672 UGMP family protein; Validated; Region: PRK09604 1114958001673 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1114958001674 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958001675 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958001676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958001677 Walker A/P-loop; other site 1114958001678 ATP binding site [chemical binding]; other site 1114958001679 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958001680 ABC transporter signature motif; other site 1114958001681 ABC transporter; Region: ABC_tran_2; pfam12848 1114958001682 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958001683 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1114958001684 trimer interface [polypeptide binding]; other site 1114958001685 dimer interface [polypeptide binding]; other site 1114958001686 putative active site [active] 1114958001687 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1114958001688 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1114958001689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958001690 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1114958001691 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1114958001692 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1114958001693 CAAX protease self-immunity; Region: Abi; cl00558 1114958001694 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1114958001695 oligomerisation interface [polypeptide binding]; other site 1114958001696 mobile loop; other site 1114958001697 roof hairpin; other site 1114958001698 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1114958001699 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1114958001700 ring oligomerisation interface [polypeptide binding]; other site 1114958001701 ATP/Mg binding site [chemical binding]; other site 1114958001702 stacking interactions; other site 1114958001703 hinge regions; other site 1114958001704 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1114958001705 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114958001706 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1114958001707 Int/Topo IB signature motif; other site 1114958001708 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1114958001709 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958001710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958001711 non-specific DNA binding site [nucleotide binding]; other site 1114958001712 salt bridge; other site 1114958001713 sequence-specific DNA binding site [nucleotide binding]; other site 1114958001714 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1114958001715 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 1114958001716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958001717 Hypothetical protein Yqai; Region: Yqai; pfam09466 1114958001718 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1114958001719 RecT family; Region: RecT; cl04285 1114958001720 Helix-turn-helix domains; Region: HTH; cl00088 1114958001721 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1114958001722 hypothetical protein; Provisional; Region: PRK06921 1114958001723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958001724 Walker A motif; other site 1114958001725 ATP binding site [chemical binding]; other site 1114958001726 Walker B motif; other site 1114958001727 arginine finger; other site 1114958001728 YopX protein; Region: YopX; cl09859 1114958001729 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1114958001730 YopX protein; Region: YopX; cl09859 1114958001731 positive control sigma-like factor; Validated; Region: PRK06930 1114958001732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958001733 DNA binding residues [nucleotide binding] 1114958001734 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1114958001735 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1114958001736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958001737 Phage terminase large subunit; Region: Terminase_3; cl12054 1114958001738 Terminase-like family; Region: Terminase_6; pfam03237 1114958001739 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1114958001740 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1114958001741 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1114958001742 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1114958001743 Phage capsid family; Region: Phage_capsid; pfam05065 1114958001744 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1114958001745 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1114958001746 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1114958001747 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1114958001748 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1114958001749 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1114958001750 Interdomain contacts; other site 1114958001751 Cytokine receptor motif; other site 1114958001752 Phage protein; Region: DUF3647; cl10335 1114958001753 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 1114958001754 membrane protein P6; Region: PHA01399 1114958001755 Phage-related protein [Function unknown]; Region: COG4722; cl15832 1114958001756 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1114958001757 Holin family; Region: Phage_holin_4; cl01989 1114958001758 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958001759 amidase catalytic site [active] 1114958001760 Zn binding residues [ion binding]; other site 1114958001761 substrate binding site [chemical binding]; other site 1114958001762 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1114958001763 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958001764 putative peptidoglycan binding site; other site 1114958001765 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958001766 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1114958001767 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1114958001768 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958001769 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1114958001770 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114958001771 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1114958001772 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1114958001773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958001774 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114958001775 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1114958001776 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114958001777 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1114958001778 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1114958001779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958001780 ATP binding site [chemical binding]; other site 1114958001781 putative Mg++ binding site [ion binding]; other site 1114958001782 silicon transporter; Region: sit; TIGR00811 1114958001783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958001784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1114958001785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958001786 binding surface 1114958001787 TPR motif; other site 1114958001788 TPR repeat; Region: TPR_11; pfam13414 1114958001789 L-idonate 5-dehydrogenase; Region: PLN02702 1114958001790 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1114958001791 inhibitor binding site; inhibition site 1114958001792 catalytic Zn binding site [ion binding]; other site 1114958001793 structural Zn binding site [ion binding]; other site 1114958001794 NADP binding site [chemical binding]; other site 1114958001795 tetramer interface [polypeptide binding]; other site 1114958001796 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1114958001797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001798 putative substrate translocation pore; other site 1114958001799 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958001800 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1114958001801 putative substrate binding site [chemical binding]; other site 1114958001802 putative ATP binding site [chemical binding]; other site 1114958001803 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1114958001804 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1114958001805 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1114958001806 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1114958001807 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1114958001808 Repair protein; Region: Repair_PSII; cl01535 1114958001809 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1114958001810 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1114958001811 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1114958001812 OpgC protein; Region: OpgC_C; cl00792 1114958001813 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1114958001814 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1114958001815 catalytic triad [active] 1114958001816 catalytic triad [active] 1114958001817 oxyanion hole [active] 1114958001818 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1114958001819 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1114958001820 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1114958001821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958001822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958001823 DNA binding residues [nucleotide binding] 1114958001824 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958001825 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1114958001826 putative NAD(P) binding site [chemical binding]; other site 1114958001827 catalytic Zn binding site [ion binding]; other site 1114958001828 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1114958001829 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1114958001830 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1114958001831 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1114958001832 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114958001833 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114958001834 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114958001835 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1114958001836 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114958001837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958001838 Walker A motif; other site 1114958001839 ATP binding site [chemical binding]; other site 1114958001840 Walker B motif; other site 1114958001841 arginine finger; other site 1114958001842 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1114958001843 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114958001844 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1114958001845 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1114958001846 GMP synthase; Reviewed; Region: guaA; PRK00074 1114958001847 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1114958001848 AMP/PPi binding site [chemical binding]; other site 1114958001849 candidate oxyanion hole; other site 1114958001850 catalytic triad [active] 1114958001851 potential glutamine specificity residues [chemical binding]; other site 1114958001852 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1114958001853 ATP Binding subdomain [chemical binding]; other site 1114958001854 Ligand Binding sites [chemical binding]; other site 1114958001855 Dimerization subdomain; other site 1114958001856 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1114958001857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958001858 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958001859 DNA binding residues [nucleotide binding] 1114958001860 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1114958001861 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114958001862 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1114958001863 hypothetical protein; Provisional; Region: PRK04164 1114958001864 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1114958001865 NETI protein; Region: NETI; pfam14044 1114958001866 AIR carboxylase; Region: AIRC; cl00310 1114958001867 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1114958001868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958001869 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958001870 adenylosuccinate lyase; Provisional; Region: PRK07492 1114958001871 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1114958001872 tetramer interface [polypeptide binding]; other site 1114958001873 active site 1114958001874 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1114958001875 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1114958001876 ATP binding site [chemical binding]; other site 1114958001877 active site 1114958001878 substrate binding site [chemical binding]; other site 1114958001879 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1114958001880 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1114958001881 putative active site [active] 1114958001882 catalytic triad [active] 1114958001883 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1114958001884 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1114958001885 dimerization interface [polypeptide binding]; other site 1114958001886 ATP binding site [chemical binding]; other site 1114958001887 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1114958001888 dimerization interface [polypeptide binding]; other site 1114958001889 ATP binding site [chemical binding]; other site 1114958001890 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1114958001891 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1114958001892 active site 1114958001893 tetramer interface [polypeptide binding]; other site 1114958001894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958001895 active site 1114958001896 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1114958001897 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1114958001898 dimerization interface [polypeptide binding]; other site 1114958001899 putative ATP binding site [chemical binding]; other site 1114958001900 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1114958001901 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1114958001902 active site 1114958001903 substrate binding site [chemical binding]; other site 1114958001904 cosubstrate binding site; other site 1114958001905 catalytic site [active] 1114958001906 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1114958001907 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1114958001908 purine monophosphate binding site [chemical binding]; other site 1114958001909 dimer interface [polypeptide binding]; other site 1114958001910 putative catalytic residues [active] 1114958001911 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1114958001912 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1114958001913 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1114958001914 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958001915 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1114958001916 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1114958001917 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1114958001918 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958001919 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1114958001920 active site 1114958001921 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958001922 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1114958001923 Helix-turn-helix domains; Region: HTH; cl00088 1114958001924 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1114958001925 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114958001926 active site 1114958001927 FMN binding site [chemical binding]; other site 1114958001928 substrate binding site [chemical binding]; other site 1114958001929 3Fe-4S cluster binding site [ion binding]; other site 1114958001930 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1114958001931 substrate binding site [chemical binding]; other site 1114958001932 putative active site [active] 1114958001933 dimer interface [polypeptide binding]; other site 1114958001934 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1114958001935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958001936 Family description; Region: UvrD_C_2; cl15862 1114958001937 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1114958001938 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1114958001939 nucleotide binding pocket [chemical binding]; other site 1114958001940 K-X-D-G motif; other site 1114958001941 catalytic site [active] 1114958001942 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1114958001943 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1114958001944 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1114958001945 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1114958001946 Dimer interface [polypeptide binding]; other site 1114958001947 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 1114958001948 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958001949 active site 1114958001950 ATP binding site [chemical binding]; other site 1114958001951 substrate binding site [chemical binding]; other site 1114958001952 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1114958001953 MgtC family; Region: MgtC; pfam02308 1114958001954 Sodium:solute symporter family; Region: SSF; cl00456 1114958001955 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1114958001956 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114958001957 Amidase; Region: Amidase; cl11426 1114958001958 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1114958001959 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1114958001960 GatB domain; Region: GatB_Yqey; cl11497 1114958001961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958001962 Helix-turn-helix domains; Region: HTH; cl00088 1114958001963 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1114958001964 Protein export membrane protein; Region: SecD_SecF; cl14618 1114958001965 putative lipid kinase; Reviewed; Region: PRK13337 1114958001966 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1114958001967 TRAM domain; Region: TRAM; cl01282 1114958001968 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1114958001969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958001970 S-adenosylmethionine binding site [chemical binding]; other site 1114958001971 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958001972 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958001973 Walker A/P-loop; other site 1114958001974 ATP binding site [chemical binding]; other site 1114958001975 Q-loop/lid; other site 1114958001976 ABC transporter signature motif; other site 1114958001977 Walker B; other site 1114958001978 D-loop; other site 1114958001979 H-loop/switch region; other site 1114958001980 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1114958001981 Protein of unknown function, DUF600; Region: DUF600; cl04640 1114958001982 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958001983 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958001984 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 1114958001985 Transcriptional regulator; Region: Transcrip_reg; cl00361 1114958001986 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1114958001987 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1114958001988 CotJB protein; Region: CotJB; pfam12652 1114958001989 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1114958001990 dimanganese center [ion binding]; other site 1114958001991 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958001992 YesK-like protein; Region: YesK; pfam14150 1114958001993 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114958001994 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114958001995 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958001996 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1114958001997 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958001998 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 1114958001999 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1114958002000 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958002001 Helix-turn-helix domains; Region: HTH; cl00088 1114958002002 hypothetical protein; Provisional; Region: PRK06847 1114958002003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002005 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1114958002006 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1114958002007 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114958002008 Cytochrome P450; Region: p450; pfam00067 1114958002009 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1114958002010 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958002011 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1114958002012 FAD binding pocket [chemical binding]; other site 1114958002013 FAD binding motif [chemical binding]; other site 1114958002014 catalytic residues [active] 1114958002015 NAD binding pocket [chemical binding]; other site 1114958002016 phosphate binding motif [ion binding]; other site 1114958002017 beta-alpha-beta structure motif; other site 1114958002018 Helix-turn-helix domains; Region: HTH; cl00088 1114958002019 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002020 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114958002021 Walker A/P-loop; other site 1114958002022 ATP binding site [chemical binding]; other site 1114958002023 Q-loop/lid; other site 1114958002024 ABC transporter signature motif; other site 1114958002025 Walker B; other site 1114958002026 D-loop; other site 1114958002027 H-loop/switch region; other site 1114958002028 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958002029 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1114958002030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002031 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 1114958002032 YcaO-like family; Region: YcaO; pfam02624 1114958002033 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 1114958002034 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1114958002035 putative FMN binding site [chemical binding]; other site 1114958002036 NADPH bind site [chemical binding]; other site 1114958002037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958002038 S-adenosylmethionine binding site [chemical binding]; other site 1114958002039 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1114958002040 Sulfatase; Region: Sulfatase; cl10460 1114958002041 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1114958002042 substrate binding site; other site 1114958002043 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1114958002044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002045 NAD(P) binding site [chemical binding]; other site 1114958002046 active site 1114958002047 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114958002048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958002049 active site 1114958002050 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114958002051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002052 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958002053 putative substrate translocation pore; other site 1114958002054 Spore germination protein; Region: Spore_permease; cl15802 1114958002055 amino acid transporter; Region: 2A0306; TIGR00909 1114958002056 Spore germination protein; Region: Spore_permease; cl15802 1114958002057 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1114958002058 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114958002059 NAD(P) binding site [chemical binding]; other site 1114958002060 catalytic residues [active] 1114958002061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958002062 dimer interface [polypeptide binding]; other site 1114958002063 putative CheW interface [polypeptide binding]; other site 1114958002064 oxidoreductase; Provisional; Region: PRK07985 1114958002065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002066 NAD(P) binding site [chemical binding]; other site 1114958002067 active site 1114958002068 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1114958002069 putative metal binding site; other site 1114958002070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958002071 binding surface 1114958002072 TPR motif; other site 1114958002073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958002074 binding surface 1114958002075 TPR motif; other site 1114958002076 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958002077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958002078 Walker A/P-loop; other site 1114958002079 ATP binding site [chemical binding]; other site 1114958002080 Q-loop/lid; other site 1114958002081 ABC transporter signature motif; other site 1114958002082 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958002083 ABC transporter; Region: ABC_tran_2; pfam12848 1114958002084 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958002085 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114958002086 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1114958002087 DNA binding residues [nucleotide binding] 1114958002088 putative dimer interface [polypeptide binding]; other site 1114958002089 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958002090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002091 putative substrate translocation pore; other site 1114958002092 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958002093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958002094 Walker A/P-loop; other site 1114958002095 ATP binding site [chemical binding]; other site 1114958002096 Q-loop/lid; other site 1114958002097 ABC transporter signature motif; other site 1114958002098 Walker B; other site 1114958002099 D-loop; other site 1114958002100 H-loop/switch region; other site 1114958002101 ABC transporter; Region: ABC_tran_2; pfam12848 1114958002102 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958002103 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114958002104 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114958002105 ATP binding site [chemical binding]; other site 1114958002106 Mg++ binding site [ion binding]; other site 1114958002107 motif III; other site 1114958002108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958002109 nucleotide binding region [chemical binding]; other site 1114958002110 ATP-binding site [chemical binding]; other site 1114958002111 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958002112 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1114958002113 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1114958002114 NAD(P) binding site [chemical binding]; other site 1114958002115 substrate binding site [chemical binding]; other site 1114958002116 dimer interface [polypeptide binding]; other site 1114958002117 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1114958002118 Heat induced stress protein YflT; Region: YflT; pfam11181 1114958002119 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1114958002120 Pectate lyase; Region: Pec_lyase_C; cl01593 1114958002121 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1114958002122 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1114958002123 transmembrane helices; other site 1114958002124 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1114958002125 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1114958002126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958002127 dimer interface [polypeptide binding]; other site 1114958002128 phosphorylation site [posttranslational modification] 1114958002129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958002130 ATP binding site [chemical binding]; other site 1114958002131 Mg2+ binding site [ion binding]; other site 1114958002132 G-X-G motif; other site 1114958002133 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958002134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958002135 active site 1114958002136 phosphorylation site [posttranslational modification] 1114958002137 intermolecular recognition site; other site 1114958002138 dimerization interface [polypeptide binding]; other site 1114958002139 Histidine kinase; Region: His_kinase; pfam06580 1114958002140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114958002141 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1114958002142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958002143 active site 1114958002144 phosphorylation site [posttranslational modification] 1114958002145 intermolecular recognition site; other site 1114958002146 dimerization interface [polypeptide binding]; other site 1114958002147 Helix-turn-helix domains; Region: HTH; cl00088 1114958002148 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1114958002149 Collagen binding domain; Region: Collagen_bind; pfam05737 1114958002150 Collagen binding domain; Region: Collagen_bind; pfam05737 1114958002151 Collagen binding domain; Region: Collagen_bind; pfam05737 1114958002152 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958002153 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958002154 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958002155 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958002156 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958002157 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958002158 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958002159 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958002160 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1114958002161 active site 1114958002162 catalytic site [active] 1114958002163 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1114958002164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958002165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958002166 ATP binding site [chemical binding]; other site 1114958002167 Mg2+ binding site [ion binding]; other site 1114958002168 G-X-G motif; other site 1114958002169 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1114958002170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958002171 active site 1114958002172 phosphorylation site [posttranslational modification] 1114958002173 intermolecular recognition site; other site 1114958002174 dimerization interface [polypeptide binding]; other site 1114958002175 Transcriptional regulator; Region: CitT; pfam12431 1114958002176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1114958002177 NMT1-like family; Region: NMT1_2; cl15260 1114958002178 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114958002179 Citrate transporter; Region: CitMHS; pfam03600 1114958002180 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958002181 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1114958002182 active site 1114958002183 dimer interface [polypeptide binding]; other site 1114958002184 Acylphosphatase; Region: Acylphosphatase; cl00551 1114958002185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1114958002186 MOSC domain; Region: MOSC; pfam03473 1114958002187 3-alpha domain; Region: 3-alpha; pfam03475 1114958002188 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1114958002189 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1114958002190 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114958002191 active site 1114958002192 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1114958002193 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958002194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958002195 active site turn [active] 1114958002196 phosphorylation site [posttranslational modification] 1114958002197 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1114958002198 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1114958002199 Sulfatase; Region: Sulfatase; cl10460 1114958002200 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1114958002201 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114958002202 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1114958002203 putative dimer interface [polypeptide binding]; other site 1114958002204 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958002205 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958002206 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1114958002207 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958002208 active site turn [active] 1114958002209 phosphorylation site [posttranslational modification] 1114958002210 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958002211 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1114958002212 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1114958002213 Ca binding site [ion binding]; other site 1114958002214 active site 1114958002215 catalytic site [active] 1114958002216 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1114958002217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958002218 DNA-binding site [nucleotide binding]; DNA binding site 1114958002219 UTRA domain; Region: UTRA; cl01230 1114958002220 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1114958002221 dimer interface [polypeptide binding]; other site 1114958002222 FMN binding site [chemical binding]; other site 1114958002223 YibE/F-like protein; Region: YibE_F; cl02259 1114958002224 YibE/F-like protein; Region: YibE_F; cl02259 1114958002225 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1114958002226 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1114958002227 active site 1114958002228 metal binding site [ion binding]; metal-binding site 1114958002229 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1114958002230 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114958002231 active site 1114958002232 metal binding site [ion binding]; metal-binding site 1114958002233 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1114958002234 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114958002235 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1114958002236 proposed catalytic triad [active] 1114958002237 conserved cys residue [active] 1114958002238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958002239 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958002240 DNA binding site [nucleotide binding] 1114958002241 domain linker motif; other site 1114958002242 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1114958002243 putative dimerization interface [polypeptide binding]; other site 1114958002244 putative ligand binding site [chemical binding]; other site 1114958002245 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1114958002246 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114958002247 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114958002248 shikimate binding site; other site 1114958002249 NAD(P) binding site [chemical binding]; other site 1114958002250 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1114958002251 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 1114958002252 active site 1114958002253 catalytic residue [active] 1114958002254 dimer interface [polypeptide binding]; other site 1114958002255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958002257 putative substrate translocation pore; other site 1114958002258 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1114958002259 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1114958002260 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1114958002261 active site 1114958002262 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1114958002263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958002265 putative substrate translocation pore; other site 1114958002266 calcium/proton exchanger (cax); Region: cax; TIGR00378 1114958002267 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114958002268 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114958002269 YfkD-like protein; Region: YfkD; pfam14167 1114958002270 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1114958002271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958002272 FeS/SAM binding site; other site 1114958002273 YfkB-like domain; Region: YfkB; pfam08756 1114958002274 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1114958002275 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1114958002276 NodB motif; other site 1114958002277 active site 1114958002278 catalytic site [active] 1114958002279 Cd binding site [ion binding]; other site 1114958002280 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1114958002281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002282 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 1114958002283 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1114958002284 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1114958002285 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114958002286 minor groove reading motif; other site 1114958002287 helix-hairpin-helix signature motif; other site 1114958002288 substrate binding pocket [chemical binding]; other site 1114958002289 active site 1114958002290 TRAM domain; Region: TRAM; cl01282 1114958002291 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1114958002292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958002293 S-adenosylmethionine binding site [chemical binding]; other site 1114958002294 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958002295 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958002296 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958002297 active site 1114958002298 ATP binding site [chemical binding]; other site 1114958002299 substrate binding site [chemical binding]; other site 1114958002300 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002301 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958002302 Walker A/P-loop; other site 1114958002303 ATP binding site [chemical binding]; other site 1114958002304 Q-loop/lid; other site 1114958002305 ABC transporter signature motif; other site 1114958002306 Walker B; other site 1114958002307 D-loop; other site 1114958002308 H-loop/switch region; other site 1114958002309 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958002311 Walker A/P-loop; other site 1114958002312 ATP binding site [chemical binding]; other site 1114958002313 Q-loop/lid; other site 1114958002314 ABC transporter signature motif; other site 1114958002315 Walker B; other site 1114958002316 D-loop; other site 1114958002317 H-loop/switch region; other site 1114958002318 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958002319 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958002320 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114958002321 NAD(P) binding site [chemical binding]; other site 1114958002322 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1114958002323 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114958002324 FMN binding site [chemical binding]; other site 1114958002325 active site 1114958002326 catalytic residues [active] 1114958002327 substrate binding site [chemical binding]; other site 1114958002328 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1114958002329 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114958002330 tetramer interface [polypeptide binding]; other site 1114958002331 TPP-binding site [chemical binding]; other site 1114958002332 heterodimer interface [polypeptide binding]; other site 1114958002333 phosphorylation loop region [posttranslational modification] 1114958002334 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114958002335 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114958002336 alpha subunit interface [polypeptide binding]; other site 1114958002337 TPP binding site [chemical binding]; other site 1114958002338 heterodimer interface [polypeptide binding]; other site 1114958002339 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958002340 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114958002341 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114958002342 E3 interaction surface; other site 1114958002343 lipoyl attachment site [posttranslational modification]; other site 1114958002344 e3 binding domain; Region: E3_binding; pfam02817 1114958002345 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1114958002346 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1114958002347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958002348 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114958002349 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1114958002350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958002351 Walker A motif; other site 1114958002352 ATP binding site [chemical binding]; other site 1114958002353 Walker B motif; other site 1114958002354 arginine finger; other site 1114958002355 Helix-turn-helix domains; Region: HTH; cl00088 1114958002356 Small acid-soluble spore protein H family; Region: SspH; cl06949 1114958002357 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1114958002358 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1114958002359 NAD binding site [chemical binding]; other site 1114958002360 sugar binding site [chemical binding]; other site 1114958002361 divalent metal binding site [ion binding]; other site 1114958002362 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958002363 dimer interface [polypeptide binding]; other site 1114958002364 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114958002365 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114958002366 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114958002367 putative active site [active] 1114958002368 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1114958002369 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958002370 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958002371 active site turn [active] 1114958002372 phosphorylation site [posttranslational modification] 1114958002373 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002374 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958002375 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958002376 Walker A/P-loop; other site 1114958002377 ATP binding site [chemical binding]; other site 1114958002378 Q-loop/lid; other site 1114958002379 ABC transporter signature motif; other site 1114958002380 Walker B; other site 1114958002381 D-loop; other site 1114958002382 H-loop/switch region; other site 1114958002383 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002384 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958002385 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1114958002386 Walker A/P-loop; other site 1114958002387 ATP binding site [chemical binding]; other site 1114958002388 Q-loop/lid; other site 1114958002389 ABC transporter signature motif; other site 1114958002390 Walker B; other site 1114958002391 D-loop; other site 1114958002392 H-loop/switch region; other site 1114958002393 DoxX; Region: DoxX; cl00976 1114958002394 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1114958002395 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1114958002396 putative metal binding site [ion binding]; other site 1114958002397 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114958002398 active site 1114958002399 metal binding site [ion binding]; metal-binding site 1114958002400 UbiA prenyltransferase family; Region: UbiA; cl00337 1114958002401 Helix-turn-helix domains; Region: HTH; cl00088 1114958002402 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1114958002403 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958002404 OpgC protein; Region: OpgC_C; cl00792 1114958002405 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114958002406 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 1114958002407 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114958002408 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1114958002409 RNAase interaction site [polypeptide binding]; other site 1114958002410 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114958002411 DinB superfamily; Region: DinB_2; pfam12867 1114958002412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002413 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958002414 putative substrate translocation pore; other site 1114958002415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002416 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958002417 Helix-turn-helix domains; Region: HTH; cl00088 1114958002418 Predicted integral membrane protein [Function unknown]; Region: COG0392 1114958002419 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1114958002420 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1114958002421 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1114958002422 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1114958002423 putative FMN binding site [chemical binding]; other site 1114958002424 YfhD-like protein; Region: YfhD; pfam14151 1114958002425 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1114958002426 TIGR01777 family protein; Region: yfcH 1114958002427 putative NAD(P) binding site [chemical binding]; other site 1114958002428 putative active site [active] 1114958002429 RecX family; Region: RecX; cl00936 1114958002430 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1114958002431 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958002432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002433 putative substrate translocation pore; other site 1114958002434 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1114958002435 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1114958002436 Small acid-soluble spore protein K family; Region: SspK; cl11509 1114958002437 WVELL protein; Region: WVELL; pfam14043 1114958002438 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958002439 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958002440 SdpI/YhfL protein family; Region: SdpI; pfam13630 1114958002441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958002442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958002443 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1114958002444 Ligand binding site; other site 1114958002445 Putative Catalytic site; other site 1114958002446 DXD motif; other site 1114958002447 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1114958002448 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1114958002449 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1114958002450 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114958002451 minor groove reading motif; other site 1114958002452 helix-hairpin-helix signature motif; other site 1114958002453 substrate binding pocket [chemical binding]; other site 1114958002454 active site 1114958002455 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1114958002456 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1114958002457 DNA binding and oxoG recognition site [nucleotide binding] 1114958002458 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114958002459 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1114958002460 putative NAD(P) binding site [chemical binding]; other site 1114958002461 active site 1114958002462 YgaB-like protein; Region: YgaB; pfam14182 1114958002463 Protein of unknown function (DUF402); Region: DUF402; cl00979 1114958002464 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002465 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958002466 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1114958002467 Walker A/P-loop; other site 1114958002468 ATP binding site [chemical binding]; other site 1114958002469 Q-loop/lid; other site 1114958002470 ABC transporter signature motif; other site 1114958002471 Walker B; other site 1114958002472 D-loop; other site 1114958002473 H-loop/switch region; other site 1114958002474 Predicted membrane protein [Function unknown]; Region: COG4129 1114958002475 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1114958002476 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1114958002477 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958002478 inhibitor-cofactor binding pocket; inhibition site 1114958002479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002480 catalytic residue [active] 1114958002481 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1114958002482 catalytic triad [active] 1114958002483 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114958002484 metal binding site 2 [ion binding]; metal-binding site 1114958002485 putative DNA binding helix; other site 1114958002486 metal binding site 1 [ion binding]; metal-binding site 1114958002487 dimer interface [polypeptide binding]; other site 1114958002488 structural Zn2+ binding site [ion binding]; other site 1114958002489 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 1114958002490 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1114958002491 active site pocket [active] 1114958002492 oxyanion hole [active] 1114958002493 catalytic triad [active] 1114958002494 active site nucleophile [active] 1114958002495 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1114958002496 ThiC-associated domain; Region: ThiC-associated; pfam13667 1114958002497 ThiC family; Region: ThiC; cl08031 1114958002498 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114958002499 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958002500 Berberine and berberine like; Region: BBE; pfam08031 1114958002501 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1114958002502 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1114958002503 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114958002504 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114958002505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958002506 dimer interface [polypeptide binding]; other site 1114958002507 conserved gate region; other site 1114958002508 putative PBP binding loops; other site 1114958002509 ABC-ATPase subunit interface; other site 1114958002510 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114958002511 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114958002512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958002513 dimer interface [polypeptide binding]; other site 1114958002514 conserved gate region; other site 1114958002515 putative PBP binding loops; other site 1114958002516 ABC-ATPase subunit interface; other site 1114958002517 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114958002518 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114958002519 Walker A/P-loop; other site 1114958002520 ATP binding site [chemical binding]; other site 1114958002521 Q-loop/lid; other site 1114958002522 ABC transporter signature motif; other site 1114958002523 Walker B; other site 1114958002524 D-loop; other site 1114958002525 H-loop/switch region; other site 1114958002526 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958002527 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114958002528 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114958002529 Walker A/P-loop; other site 1114958002530 ATP binding site [chemical binding]; other site 1114958002531 Q-loop/lid; other site 1114958002532 ABC transporter signature motif; other site 1114958002533 Walker B; other site 1114958002534 D-loop; other site 1114958002535 H-loop/switch region; other site 1114958002536 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958002537 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114958002538 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1114958002539 tetramer interface [polypeptide binding]; other site 1114958002540 heme binding pocket [chemical binding]; other site 1114958002541 NADPH binding site [chemical binding]; other site 1114958002542 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1114958002543 active site 1114958002544 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114958002545 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1114958002546 Walker A/P-loop; other site 1114958002547 ATP binding site [chemical binding]; other site 1114958002548 Q-loop/lid; other site 1114958002549 ABC transporter signature motif; other site 1114958002550 Walker B; other site 1114958002551 D-loop; other site 1114958002552 H-loop/switch region; other site 1114958002553 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114958002554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958002555 substrate binding pocket [chemical binding]; other site 1114958002556 membrane-bound complex binding site; other site 1114958002557 hinge residues; other site 1114958002558 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114958002559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958002560 dimer interface [polypeptide binding]; other site 1114958002561 conserved gate region; other site 1114958002562 putative PBP binding loops; other site 1114958002563 ABC-ATPase subunit interface; other site 1114958002564 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1114958002565 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1114958002566 active site 1114958002567 dimer interface [polypeptide binding]; other site 1114958002568 non-prolyl cis peptide bond; other site 1114958002569 insertion regions; other site 1114958002570 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1114958002571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958002572 non-specific DNA binding site [nucleotide binding]; other site 1114958002573 salt bridge; other site 1114958002574 sequence-specific DNA binding site [nucleotide binding]; other site 1114958002575 B3/4 domain; Region: B3_4; cl11458 1114958002576 iron-sulfur cluster binding protein, putative; Region: TIGR00276 1114958002577 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1114958002578 HEAT repeats; Region: HEAT_2; pfam13646 1114958002579 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 1114958002580 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958002581 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1114958002582 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1114958002583 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1114958002584 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1114958002585 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1114958002586 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1114958002587 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1114958002588 Uncharacterized conserved protein [Function unknown]; Region: COG2718 1114958002589 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114958002590 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958002591 Helix-turn-helix domains; Region: HTH; cl00088 1114958002592 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114958002593 carboxyltransferase (CT) interaction site; other site 1114958002594 biotinylation site [posttranslational modification]; other site 1114958002595 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114958002596 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114958002597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002598 putative substrate translocation pore; other site 1114958002599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002600 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958002601 Predicted transcriptional regulators [Transcription]; Region: COG1725 1114958002602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958002603 DNA-binding site [nucleotide binding]; DNA binding site 1114958002604 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114958002605 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114958002606 Walker A/P-loop; other site 1114958002607 ATP binding site [chemical binding]; other site 1114958002608 Q-loop/lid; other site 1114958002609 ABC transporter signature motif; other site 1114958002610 Walker B; other site 1114958002611 D-loop; other site 1114958002612 H-loop/switch region; other site 1114958002613 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002614 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1114958002615 Walker A/P-loop; other site 1114958002616 ATP binding site [chemical binding]; other site 1114958002617 Q-loop/lid; other site 1114958002618 ABC transporter signature motif; other site 1114958002619 Walker B; other site 1114958002620 D-loop; other site 1114958002621 H-loop/switch region; other site 1114958002622 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958002623 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114958002624 DNA-binding site [nucleotide binding]; DNA binding site 1114958002625 RNA-binding motif; other site 1114958002626 NMT1-like family; Region: NMT1_2; cl15260 1114958002627 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1114958002628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114958002629 metal binding site [ion binding]; metal-binding site 1114958002630 active site 1114958002631 I-site; other site 1114958002632 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114958002633 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114958002634 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1114958002635 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1114958002636 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1114958002637 Coat F domain; Region: Coat_F; cl15836 1114958002638 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1114958002639 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1114958002640 putative active site [active] 1114958002641 putative metal binding site [ion binding]; other site 1114958002642 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1114958002643 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 1114958002644 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1114958002645 active site 1114958002646 catalytic site [active] 1114958002647 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1114958002648 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114958002649 active site 1114958002650 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958002651 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1114958002652 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1114958002653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958002654 motif II; other site 1114958002655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958002656 Coenzyme A binding pocket [chemical binding]; other site 1114958002657 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114958002658 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1114958002659 putative active site [active] 1114958002660 catalytic triad [active] 1114958002661 putative dimer interface [polypeptide binding]; other site 1114958002662 aminotransferase; Validated; Region: PRK07678 1114958002663 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958002664 inhibitor-cofactor binding pocket; inhibition site 1114958002665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002666 catalytic residue [active] 1114958002667 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1114958002668 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1114958002669 amphipathic channel; other site 1114958002670 Asn-Pro-Ala signature motifs; other site 1114958002671 glycerol kinase; Provisional; Region: glpK; PRK00047 1114958002672 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1114958002673 N- and C-terminal domain interface [polypeptide binding]; other site 1114958002674 active site 1114958002675 MgATP binding site [chemical binding]; other site 1114958002676 catalytic site [active] 1114958002677 metal binding site [ion binding]; metal-binding site 1114958002678 glycerol binding site [chemical binding]; other site 1114958002679 homotetramer interface [polypeptide binding]; other site 1114958002680 homodimer interface [polypeptide binding]; other site 1114958002681 FBP binding site [chemical binding]; other site 1114958002682 protein IIAGlc interface [polypeptide binding]; other site 1114958002683 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1114958002684 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1114958002685 active site 1114958002686 substrate binding site [chemical binding]; other site 1114958002687 metal binding site [ion binding]; metal-binding site 1114958002688 GAF domain; Region: GAF_2; pfam13185 1114958002689 GAF domain; Region: GAF; cl15785 1114958002690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114958002691 Histidine kinase; Region: HisKA_3; pfam07730 1114958002692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958002693 ATP binding site [chemical binding]; other site 1114958002694 Mg2+ binding site [ion binding]; other site 1114958002695 G-X-G motif; other site 1114958002696 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958002697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958002698 active site 1114958002699 phosphorylation site [posttranslational modification] 1114958002700 intermolecular recognition site; other site 1114958002701 dimerization interface [polypeptide binding]; other site 1114958002702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958002703 DNA binding residues [nucleotide binding] 1114958002704 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958002705 YhdB-like protein; Region: YhdB; pfam14148 1114958002706 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1114958002707 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958002708 putative peptidoglycan binding site; other site 1114958002709 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958002710 putative peptidoglycan binding site; other site 1114958002711 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958002712 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958002713 putative peptidoglycan binding site; other site 1114958002714 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958002715 putative peptidoglycan binding site; other site 1114958002716 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958002717 putative peptidoglycan binding site; other site 1114958002718 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958002719 Helix-turn-helix domains; Region: HTH; cl00088 1114958002720 Rrf2 family protein; Region: rrf2_super; TIGR00738 1114958002721 Conserved TM helix; Region: TM_helix; pfam05552 1114958002722 Conserved TM helix; Region: TM_helix; pfam05552 1114958002723 Conserved TM helix; Region: TM_helix; pfam05552 1114958002724 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1114958002725 SpoVR like protein; Region: SpoVR; pfam04293 1114958002726 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1114958002727 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1114958002728 dimer interface [polypeptide binding]; other site 1114958002729 active site 1114958002730 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958002731 putative peptidoglycan binding site; other site 1114958002732 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958002733 putative peptidoglycan binding site; other site 1114958002734 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958002735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958002736 Helix-turn-helix domains; Region: HTH; cl00088 1114958002737 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958002738 dimerization interface [polypeptide binding]; other site 1114958002739 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1114958002740 dimer interface [polypeptide binding]; other site 1114958002741 Citrate synthase; Region: Citrate_synt; pfam00285 1114958002742 active site 1114958002743 citrylCoA binding site [chemical binding]; other site 1114958002744 oxalacetate/citrate binding site [chemical binding]; other site 1114958002745 coenzyme A binding site [chemical binding]; other site 1114958002746 catalytic triad [active] 1114958002747 short chain dehydrogenase; Provisional; Region: PRK06701 1114958002748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002749 NAD(P) binding site [chemical binding]; other site 1114958002750 active site 1114958002751 Spore germination protein; Region: Spore_permease; cl15802 1114958002752 amino acid transporter; Region: 2A0306; TIGR00909 1114958002753 Spore germination protein; Region: Spore_permease; cl15802 1114958002754 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 1114958002755 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1114958002756 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1114958002757 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1114958002758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958002759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958002760 DNA binding residues [nucleotide binding] 1114958002761 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114958002762 putative acyl-acceptor binding pocket; other site 1114958002763 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114958002764 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114958002765 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114958002766 Transporter associated domain; Region: CorC_HlyC; cl08393 1114958002767 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1114958002768 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114958002769 DNA binding residues [nucleotide binding] 1114958002770 putative dimer interface [polypeptide binding]; other site 1114958002771 aspartate aminotransferase; Provisional; Region: PRK06836 1114958002772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958002773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002774 homodimer interface [polypeptide binding]; other site 1114958002775 catalytic residue [active] 1114958002776 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1114958002777 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114958002778 dimer interface [polypeptide binding]; other site 1114958002779 active site 1114958002780 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114958002781 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114958002782 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114958002783 Transporter associated domain; Region: CorC_HlyC; cl08393 1114958002784 CrcB-like protein; Region: CRCB; cl09114 1114958002785 CrcB-like protein; Region: CRCB; cl09114 1114958002786 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114958002787 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1114958002788 active site 1114958002789 catalytic site [active] 1114958002790 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114958002791 NAD-dependent deacetylase; Provisional; Region: PRK00481 1114958002792 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1114958002793 NAD+ binding site [chemical binding]; other site 1114958002794 substrate binding site [chemical binding]; other site 1114958002795 Zn binding site [ion binding]; other site 1114958002796 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1114958002797 NodB motif; other site 1114958002798 active site 1114958002799 catalytic site [active] 1114958002800 Zn binding site [ion binding]; other site 1114958002801 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1114958002802 homodimer interface [polypeptide binding]; other site 1114958002803 substrate-cofactor binding pocket; other site 1114958002804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002805 catalytic residue [active] 1114958002806 Helix-turn-helix domains; Region: HTH; cl00088 1114958002807 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1114958002808 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114958002809 Ligand Binding Site [chemical binding]; other site 1114958002810 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958002811 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1114958002812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958002813 Walker A/P-loop; other site 1114958002814 ATP binding site [chemical binding]; other site 1114958002815 Q-loop/lid; other site 1114958002816 ABC transporter signature motif; other site 1114958002817 Walker B; other site 1114958002818 D-loop; other site 1114958002819 H-loop/switch region; other site 1114958002820 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002821 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958002822 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1114958002823 Walker A/P-loop; other site 1114958002824 ATP binding site [chemical binding]; other site 1114958002825 Q-loop/lid; other site 1114958002826 ABC transporter signature motif; other site 1114958002827 Walker B; other site 1114958002828 D-loop; other site 1114958002829 H-loop/switch region; other site 1114958002830 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1114958002831 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114958002832 NAD binding site [chemical binding]; other site 1114958002833 substrate binding site [chemical binding]; other site 1114958002834 putative active site [active] 1114958002835 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1114958002836 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958002837 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958002838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1114958002839 Protein of unknown function (DUF964); Region: DUF964; cl01483 1114958002840 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1114958002841 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958002842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958002843 active site 1114958002844 motif I; other site 1114958002845 motif II; other site 1114958002846 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958002847 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1114958002848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958002849 FeS/SAM binding site; other site 1114958002850 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1114958002851 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114958002852 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1114958002853 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1114958002854 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114958002855 enoyl-CoA hydratase; Provisional; Region: PRK07659 1114958002856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958002857 substrate binding site [chemical binding]; other site 1114958002858 oxyanion hole (OAH) forming residues; other site 1114958002859 trimer interface [polypeptide binding]; other site 1114958002860 YhzD-like protein; Region: YhzD; pfam14120 1114958002861 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1114958002862 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 1114958002863 Walker A/P-loop; other site 1114958002864 ATP binding site [chemical binding]; other site 1114958002865 Q-loop/lid; other site 1114958002866 ABC transporter signature motif; other site 1114958002867 Walker B; other site 1114958002868 D-loop; other site 1114958002869 H-loop/switch region; other site 1114958002870 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1114958002871 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114958002872 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958002873 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1114958002874 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958002875 active site 1114958002876 metal binding site [ion binding]; metal-binding site 1114958002877 DNA binding site [nucleotide binding] 1114958002878 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1114958002879 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1114958002880 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 1114958002881 generic binding surface II; other site 1114958002882 generic binding surface I; other site 1114958002883 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958002884 Zn2+ binding site [ion binding]; other site 1114958002885 Mg2+ binding site [ion binding]; other site 1114958002886 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1114958002887 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1114958002888 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1114958002889 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1114958002890 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1114958002891 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1114958002892 transcriptional regulator Hpr; Provisional; Region: PRK13777 1114958002893 Helix-turn-helix domains; Region: HTH; cl00088 1114958002894 YtxH-like protein; Region: YtxH; cl02079 1114958002895 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1114958002896 homodimer interface [polypeptide binding]; other site 1114958002897 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114958002898 substrate-cofactor binding pocket; other site 1114958002899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002900 catalytic residue [active] 1114958002901 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1114958002902 HIT family signature motif; other site 1114958002903 catalytic residue [active] 1114958002904 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1114958002905 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114958002906 Walker A/P-loop; other site 1114958002907 ATP binding site [chemical binding]; other site 1114958002908 Q-loop/lid; other site 1114958002909 ABC transporter signature motif; other site 1114958002910 Walker B; other site 1114958002911 D-loop; other site 1114958002912 H-loop/switch region; other site 1114958002913 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1114958002914 EcsC protein family; Region: EcsC; pfam12787 1114958002915 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1114958002916 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1114958002917 metal binding site [ion binding]; metal-binding site 1114958002918 dimer interface [polypeptide binding]; other site 1114958002919 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114958002920 Transglycosylase; Region: Transgly; cl07896 1114958002921 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1114958002922 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958002923 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1114958002924 substrate binding site [chemical binding]; other site 1114958002925 active site 1114958002926 ferrochelatase; Provisional; Region: PRK12435 1114958002927 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1114958002928 C-terminal domain interface [polypeptide binding]; other site 1114958002929 active site 1114958002930 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1114958002931 active site 1114958002932 N-terminal domain interface [polypeptide binding]; other site 1114958002933 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1114958002934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958002936 Helix-turn-helix domains; Region: HTH; cl00088 1114958002937 Predicted membrane protein [Function unknown]; Region: COG1511 1114958002938 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114958002939 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958002940 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1114958002941 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114958002942 dimer interface [polypeptide binding]; other site 1114958002943 active site 1114958002944 CoA binding pocket [chemical binding]; other site 1114958002945 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1114958002946 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1114958002947 putative oligomer interface [polypeptide binding]; other site 1114958002948 putative active site [active] 1114958002949 metal binding site [ion binding]; metal-binding site 1114958002950 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114958002951 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114958002952 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958002953 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1114958002954 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1114958002955 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1114958002956 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1114958002957 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114958002958 NAD(P) binding site [chemical binding]; other site 1114958002959 putative active site [active] 1114958002960 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1114958002961 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958002962 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958002963 Peptidase family M48; Region: Peptidase_M48; cl12018 1114958002964 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1114958002965 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1114958002966 active site 1114958002967 catalytic residues [active] 1114958002968 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1114958002969 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1114958002970 siderophore binding site; other site 1114958002971 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114958002972 catalytic core [active] 1114958002973 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1114958002974 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114958002975 dimer interface [polypeptide binding]; other site 1114958002976 active site 1114958002977 acyl-CoA synthetase; Validated; Region: PRK07638 1114958002978 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958002979 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1114958002980 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1114958002981 heme-binding site [chemical binding]; other site 1114958002982 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958002983 dimer interface [polypeptide binding]; other site 1114958002984 putative CheW interface [polypeptide binding]; other site 1114958002985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002986 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114958002987 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1114958002988 [2Fe-2S] cluster binding site [ion binding]; other site 1114958002989 short chain dehydrogenase; Provisional; Region: PRK06701 1114958002990 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1114958002991 NAD binding site [chemical binding]; other site 1114958002992 metal binding site [ion binding]; metal-binding site 1114958002993 active site 1114958002994 IDEAL domain; Region: IDEAL; cl07452 1114958002995 ComK protein; Region: ComK; cl11560 1114958002996 Protein of unknown function (DUF419); Region: DUF419; cl15265 1114958002997 Protein of unknown function (DUF419); Region: DUF419; cl15265 1114958002998 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1114958002999 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1114958003000 Sodium:solute symporter family; Region: SSF; cl00456 1114958003001 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1114958003002 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1114958003003 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114958003004 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1114958003005 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114958003006 Catalytic site [active] 1114958003007 hypothetical protein; Provisional; Region: PRK08244 1114958003008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003009 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958003010 Helix-turn-helix domains; Region: HTH; cl00088 1114958003011 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1114958003012 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1114958003013 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1114958003014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003015 putative substrate translocation pore; other site 1114958003016 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958003017 Helix-turn-helix domains; Region: HTH; cl00088 1114958003018 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1114958003019 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1114958003020 dinuclear metal binding motif [ion binding]; other site 1114958003021 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114958003022 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1114958003023 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1114958003024 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1114958003025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958003026 Family description; Region: UvrD_C_2; cl15862 1114958003027 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1114958003028 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1114958003029 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1114958003030 active site 1114958003031 metal binding site [ion binding]; metal-binding site 1114958003032 DNA binding site [nucleotide binding] 1114958003033 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1114958003034 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1114958003035 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1114958003036 Walker A/P-loop; other site 1114958003037 ATP binding site [chemical binding]; other site 1114958003038 Q-loop/lid; other site 1114958003039 ABC transporter signature motif; other site 1114958003040 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1114958003041 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1114958003042 ABC transporter signature motif; other site 1114958003043 Walker B; other site 1114958003044 D-loop; other site 1114958003045 H-loop/switch region; other site 1114958003046 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1114958003047 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958003048 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1114958003049 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1114958003050 Spore germination protein GerPC; Region: GerPC; pfam10737 1114958003051 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1114958003052 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958003053 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1114958003054 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114958003055 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114958003056 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 1114958003057 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1114958003058 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1114958003059 active site 1114958003060 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1114958003061 dimer interface [polypeptide binding]; other site 1114958003062 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1114958003063 Ligand Binding Site [chemical binding]; other site 1114958003064 Molecular Tunnel; other site 1114958003065 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1114958003066 substrate binding pocket [chemical binding]; other site 1114958003067 substrate-Mg2+ binding site; other site 1114958003068 aspartate-rich region 1; other site 1114958003069 aspartate-rich region 2; other site 1114958003070 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1114958003071 MatE; Region: MatE; cl10513 1114958003072 MatE; Region: MatE; cl10513 1114958003073 Cupin domain; Region: Cupin_2; cl09118 1114958003074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958003075 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958003076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958003077 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958003078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958003079 DNA binding site [nucleotide binding] 1114958003080 domain linker motif; other site 1114958003081 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114958003082 dimerization interface [polypeptide binding]; other site 1114958003083 ligand binding site [chemical binding]; other site 1114958003084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114958003085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003086 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114958003087 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114958003088 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1114958003089 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958003090 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1114958003091 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1114958003092 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1114958003093 FAD binding site [chemical binding]; other site 1114958003094 Protein of unknown function (DUF520); Region: DUF520; cl00723 1114958003095 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1114958003096 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114958003097 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114958003098 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1114958003099 ligand binding site [chemical binding]; other site 1114958003100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958003101 dimerization interface [polypeptide binding]; other site 1114958003102 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958003103 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958003104 dimer interface [polypeptide binding]; other site 1114958003105 putative CheW interface [polypeptide binding]; other site 1114958003106 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1114958003107 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958003108 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958003109 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958003110 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1114958003111 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1114958003112 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1114958003113 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958003114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958003115 motif II; other site 1114958003116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958003117 esterase; Provisional; Region: PRK10566 1114958003118 Domain of unknown function DUF59; Region: DUF59; cl00941 1114958003119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958003120 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114958003121 active site 1114958003122 metal binding site [ion binding]; metal-binding site 1114958003123 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114958003124 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958003125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003126 putative substrate translocation pore; other site 1114958003127 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1114958003128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003129 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114958003130 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1114958003131 heterotetramer interface [polypeptide binding]; other site 1114958003132 active site pocket [active] 1114958003133 cleavage site 1114958003134 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1114958003135 nucleotide binding site [chemical binding]; other site 1114958003136 N-acetyl-L-glutamate binding site [chemical binding]; other site 1114958003137 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1114958003138 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958003139 inhibitor-cofactor binding pocket; inhibition site 1114958003140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003141 catalytic residue [active] 1114958003142 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1114958003143 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1114958003144 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1114958003145 catalytic site [active] 1114958003146 subunit interface [polypeptide binding]; other site 1114958003147 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1114958003148 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958003149 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958003150 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1114958003151 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958003152 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958003153 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1114958003154 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114958003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003156 YjzC-like protein; Region: YjzC; pfam14168 1114958003157 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1114958003158 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114958003159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003160 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1114958003161 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1114958003162 putative ligand binding site [chemical binding]; other site 1114958003163 ComZ; Region: ComZ; pfam10815 1114958003164 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1114958003165 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114958003166 dimer interface [polypeptide binding]; other site 1114958003167 active site 1114958003168 CoA binding pocket [chemical binding]; other site 1114958003169 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1114958003170 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114958003171 dimer interface [polypeptide binding]; other site 1114958003172 active site 1114958003173 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1114958003174 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114958003175 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114958003176 Walker A/P-loop; other site 1114958003177 ATP binding site [chemical binding]; other site 1114958003178 Q-loop/lid; other site 1114958003179 ABC transporter signature motif; other site 1114958003180 Walker B; other site 1114958003181 D-loop; other site 1114958003182 H-loop/switch region; other site 1114958003183 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003184 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114958003185 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114958003186 Walker A/P-loop; other site 1114958003187 ATP binding site [chemical binding]; other site 1114958003188 Q-loop/lid; other site 1114958003189 ABC transporter signature motif; other site 1114958003190 Walker B; other site 1114958003191 D-loop; other site 1114958003192 H-loop/switch region; other site 1114958003193 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003194 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114958003195 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1114958003196 peptide binding site [polypeptide binding]; other site 1114958003197 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114958003198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003199 dimer interface [polypeptide binding]; other site 1114958003200 conserved gate region; other site 1114958003201 putative PBP binding loops; other site 1114958003202 ABC-ATPase subunit interface; other site 1114958003203 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114958003204 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114958003205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003206 dimer interface [polypeptide binding]; other site 1114958003207 conserved gate region; other site 1114958003208 putative PBP binding loops; other site 1114958003209 ABC-ATPase subunit interface; other site 1114958003210 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1114958003211 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1114958003212 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1114958003213 active site 1114958003214 HIGH motif; other site 1114958003215 dimer interface [polypeptide binding]; other site 1114958003216 KMSKS motif; other site 1114958003217 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114958003218 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1114958003219 peptide binding site [polypeptide binding]; other site 1114958003220 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1114958003221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003222 dimer interface [polypeptide binding]; other site 1114958003223 conserved gate region; other site 1114958003224 putative PBP binding loops; other site 1114958003225 ABC-ATPase subunit interface; other site 1114958003226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114958003227 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114958003228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003229 dimer interface [polypeptide binding]; other site 1114958003230 conserved gate region; other site 1114958003231 putative PBP binding loops; other site 1114958003232 ABC-ATPase subunit interface; other site 1114958003233 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114958003234 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114958003235 Walker A/P-loop; other site 1114958003236 ATP binding site [chemical binding]; other site 1114958003237 Q-loop/lid; other site 1114958003238 ABC transporter signature motif; other site 1114958003239 Walker B; other site 1114958003240 D-loop; other site 1114958003241 H-loop/switch region; other site 1114958003242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003243 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1114958003244 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114958003245 Walker A/P-loop; other site 1114958003246 ATP binding site [chemical binding]; other site 1114958003247 Q-loop/lid; other site 1114958003248 ABC transporter signature motif; other site 1114958003249 Walker B; other site 1114958003250 D-loop; other site 1114958003251 H-loop/switch region; other site 1114958003252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003253 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 1114958003254 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958003255 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1114958003256 ArsC family; Region: ArsC; pfam03960 1114958003257 putative catalytic residues [active] 1114958003258 thiol/disulfide switch; other site 1114958003259 Integral membrane protein TerC family; Region: TerC; cl10468 1114958003260 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1114958003261 Competence protein CoiA-like family; Region: CoiA; cl11541 1114958003262 oligoendopeptidase F; Region: pepF; TIGR00181 1114958003263 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1114958003264 active site 1114958003265 Zn binding site [ion binding]; other site 1114958003266 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1114958003267 Thioredoxin; Region: Thioredoxin_5; pfam13743 1114958003268 catalytic residues [active] 1114958003269 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1114958003270 apolar tunnel; other site 1114958003271 heme binding site [chemical binding]; other site 1114958003272 dimerization interface [polypeptide binding]; other site 1114958003273 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114958003274 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958003275 catalytic residue [active] 1114958003276 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1114958003277 putative active site [active] 1114958003278 putative metal binding residues [ion binding]; other site 1114958003279 signature motif; other site 1114958003280 putative triphosphate binding site [ion binding]; other site 1114958003281 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114958003282 synthetase active site [active] 1114958003283 NTP binding site [chemical binding]; other site 1114958003284 metal binding site [ion binding]; metal-binding site 1114958003285 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1114958003286 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1114958003287 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114958003288 active site 1114958003289 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1114958003290 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1114958003291 active site 1114958003292 metal binding site [ion binding]; metal-binding site 1114958003293 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1114958003294 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114958003295 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114958003296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003297 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114958003298 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1114958003299 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114958003300 thiamine phosphate binding site [chemical binding]; other site 1114958003301 active site 1114958003302 pyrophosphate binding site [ion binding]; other site 1114958003303 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114958003304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003305 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1114958003306 thiS-thiF/thiG interaction site; other site 1114958003307 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1114958003308 ThiS interaction site; other site 1114958003309 putative active site [active] 1114958003310 tetramer interface [polypeptide binding]; other site 1114958003311 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1114958003312 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114958003313 ATP binding site [chemical binding]; other site 1114958003314 substrate interface [chemical binding]; other site 1114958003315 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114958003316 dimer interface [polypeptide binding]; other site 1114958003317 substrate binding site [chemical binding]; other site 1114958003318 ATP binding site [chemical binding]; other site 1114958003319 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1114958003320 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1114958003321 NAD binding site [chemical binding]; other site 1114958003322 homotetramer interface [polypeptide binding]; other site 1114958003323 homodimer interface [polypeptide binding]; other site 1114958003324 substrate binding site [chemical binding]; other site 1114958003325 active site 1114958003326 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1114958003327 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1114958003328 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1114958003329 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1114958003330 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1114958003331 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1114958003332 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1114958003333 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1114958003334 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114958003335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958003336 Family description; Region: UvrD_C_2; cl15862 1114958003337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958003338 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958003339 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1114958003340 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 1114958003341 Walker A/P-loop; other site 1114958003342 ATP binding site [chemical binding]; other site 1114958003343 Q-loop/lid; other site 1114958003344 ABC transporter signature motif; other site 1114958003345 Walker B; other site 1114958003346 D-loop; other site 1114958003347 H-loop/switch region; other site 1114958003348 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1114958003349 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958003350 hypothetical protein; Provisional; Region: PRK13679 1114958003351 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1114958003352 Putative esterase; Region: Esterase; pfam00756 1114958003353 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958003354 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1114958003355 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114958003356 homodimer interface [polypeptide binding]; other site 1114958003357 substrate-cofactor binding pocket; other site 1114958003358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003359 catalytic residue [active] 1114958003360 cystathionine beta-lyase; Provisional; Region: PRK08064 1114958003361 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114958003362 homodimer interface [polypeptide binding]; other site 1114958003363 substrate-cofactor binding pocket; other site 1114958003364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003365 catalytic residue [active] 1114958003366 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958003367 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958003368 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114958003369 active site 1114958003370 metal binding site [ion binding]; metal-binding site 1114958003371 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1114958003372 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958003373 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114958003374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958003375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003376 putative substrate translocation pore; other site 1114958003377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003378 Helix-turn-helix domains; Region: HTH; cl00088 1114958003379 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1114958003380 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1114958003381 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1114958003382 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1114958003383 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1114958003384 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1114958003385 NAD binding site [chemical binding]; other site 1114958003386 homodimer interface [polypeptide binding]; other site 1114958003387 active site 1114958003388 substrate binding site [chemical binding]; other site 1114958003389 galactokinase; Provisional; Region: PRK05322 1114958003390 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1114958003391 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1114958003392 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1114958003393 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958003394 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1114958003395 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1114958003396 active site 1114958003397 P-loop; other site 1114958003398 phosphorylation site [posttranslational modification] 1114958003399 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1114958003400 methionine cluster; other site 1114958003401 active site 1114958003402 phosphorylation site [posttranslational modification] 1114958003403 metal binding site [ion binding]; metal-binding site 1114958003404 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1114958003405 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958003406 Helix-turn-helix domains; Region: HTH; cl00088 1114958003407 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114958003408 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1114958003409 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958003410 MgtC family; Region: MgtC; pfam02308 1114958003411 Putative motility protein; Region: YjfB_motility; pfam14070 1114958003412 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1114958003413 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1114958003414 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1114958003415 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114958003416 catalytic loop [active] 1114958003417 iron binding site [ion binding]; other site 1114958003418 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1114958003419 4Fe-4S binding domain; Region: Fer4; cl02805 1114958003420 4Fe-4S binding domain; Region: Fer4; cl02805 1114958003421 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1114958003422 [4Fe-4S] binding site [ion binding]; other site 1114958003423 molybdopterin cofactor binding site; other site 1114958003424 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1114958003425 molybdopterin cofactor binding site; other site 1114958003426 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1114958003427 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114958003428 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1114958003429 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1114958003430 active site 1114958003431 TDP-binding site; other site 1114958003432 acceptor substrate-binding pocket; other site 1114958003433 homodimer interface [polypeptide binding]; other site 1114958003434 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1114958003435 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114958003436 active site 1114958003437 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1114958003438 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1114958003439 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1114958003440 Walker A/P-loop; other site 1114958003441 ATP binding site [chemical binding]; other site 1114958003442 Q-loop/lid; other site 1114958003443 ABC transporter signature motif; other site 1114958003444 Walker B; other site 1114958003445 D-loop; other site 1114958003446 H-loop/switch region; other site 1114958003447 EamA-like transporter family; Region: EamA; cl01037 1114958003448 Cupin domain; Region: Cupin_2; cl09118 1114958003449 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1114958003450 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114958003451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958003452 Glucuronate isomerase; Region: UxaC; cl00829 1114958003453 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1114958003454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003455 putative substrate translocation pore; other site 1114958003456 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958003457 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958003458 DNA binding site [nucleotide binding] 1114958003459 domain linker motif; other site 1114958003460 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114958003461 dimerization interface [polypeptide binding]; other site 1114958003462 ligand binding site [chemical binding]; other site 1114958003463 altronate oxidoreductase; Provisional; Region: PRK03643 1114958003464 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1114958003465 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1114958003466 SAF domain; Region: SAF; cl00555 1114958003467 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 1114958003468 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1114958003469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958003470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958003471 active site 1114958003472 phosphorylation site [posttranslational modification] 1114958003473 intermolecular recognition site; other site 1114958003474 dimerization interface [polypeptide binding]; other site 1114958003475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958003476 DNA binding site [nucleotide binding] 1114958003477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114958003478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114958003479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958003480 dimer interface [polypeptide binding]; other site 1114958003481 phosphorylation site [posttranslational modification] 1114958003482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958003483 ATP binding site [chemical binding]; other site 1114958003484 Mg2+ binding site [ion binding]; other site 1114958003485 G-X-G motif; other site 1114958003486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958003487 Walker A/P-loop; other site 1114958003488 ATP binding site [chemical binding]; other site 1114958003489 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114958003490 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114958003491 DinB superfamily; Region: DinB_2; pfam12867 1114958003492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958003493 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1114958003494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958003495 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958003496 amidase catalytic site [active] 1114958003497 Zn binding residues [ion binding]; other site 1114958003498 substrate binding site [chemical binding]; other site 1114958003499 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958003500 putative peptidoglycan binding site; other site 1114958003501 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958003502 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1114958003503 Protein of unknown function (DUF867); Region: DUF867; cl01713 1114958003504 Domain of unknown function (DUF955); Region: DUF955; cl01076 1114958003505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958003506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958003507 non-specific DNA binding site [nucleotide binding]; other site 1114958003508 salt bridge; other site 1114958003509 sequence-specific DNA binding site [nucleotide binding]; other site 1114958003510 Predicted transcriptional regulators [Transcription]; Region: COG1725 1114958003511 hypothetical protein; Provisional; Region: PRK06921 1114958003512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958003513 Walker A motif; other site 1114958003514 ATP binding site [chemical binding]; other site 1114958003515 Walker B motif; other site 1114958003516 positive control sigma-like factor; Validated; Region: PRK06930 1114958003517 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958003518 DNA binding residues [nucleotide binding] 1114958003519 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1114958003520 Terminase small subunit; Region: Terminase_2; cl01513 1114958003521 Phage terminase large subunit; Region: Terminase_3; cl12054 1114958003522 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1114958003523 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 1114958003524 Phage capsid family; Region: Phage_capsid; pfam05065 1114958003525 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1114958003526 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1114958003527 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1114958003528 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1114958003529 Phage XkdN-like protein; Region: XkdN; pfam08890 1114958003530 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114958003531 Phage-related protein [Function unknown]; Region: COG5412 1114958003532 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114958003533 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958003534 catalytic residue [active] 1114958003535 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1114958003536 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958003537 putative peptidoglycan binding site; other site 1114958003538 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1114958003539 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1114958003540 Baseplate J-like protein; Region: Baseplate_J; cl01294 1114958003541 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1114958003542 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1114958003543 XkdW protein; Region: XkdW; pfam09636 1114958003544 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1114958003545 Haemolysin XhlA; Region: XhlA; pfam10779 1114958003546 Phage lysis protein, holin; Region: Phage_holin; cl04675 1114958003547 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958003548 amidase catalytic site [active] 1114958003549 Zn binding residues [ion binding]; other site 1114958003550 substrate binding site [chemical binding]; other site 1114958003551 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958003552 putative peptidoglycan binding site; other site 1114958003553 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958003554 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1114958003555 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1114958003556 Phosphate transporter family; Region: PHO4; cl00396 1114958003557 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1114958003558 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1114958003559 Spore germination protein; Region: Spore_permease; cl15802 1114958003560 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1114958003561 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958003562 Zn binding site [ion binding]; other site 1114958003563 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1114958003564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958003565 Zn binding site [ion binding]; other site 1114958003566 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1114958003567 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1114958003568 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1114958003569 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1114958003570 Ligand binding site; other site 1114958003571 Putative Catalytic site; other site 1114958003572 DXD motif; other site 1114958003573 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1114958003574 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958003575 protein binding site [polypeptide binding]; other site 1114958003576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003577 putative substrate translocation pore; other site 1114958003578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958003579 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1114958003580 SxDxEG motif; other site 1114958003581 active site 1114958003582 metal binding site [ion binding]; metal-binding site 1114958003583 homopentamer interface [polypeptide binding]; other site 1114958003584 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114958003585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003586 dimer interface [polypeptide binding]; other site 1114958003587 conserved gate region; other site 1114958003588 putative PBP binding loops; other site 1114958003589 ABC-ATPase subunit interface; other site 1114958003590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114958003591 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114958003592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003593 dimer interface [polypeptide binding]; other site 1114958003594 conserved gate region; other site 1114958003595 putative PBP binding loops; other site 1114958003596 ABC-ATPase subunit interface; other site 1114958003597 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114958003598 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114958003599 Walker A/P-loop; other site 1114958003600 ATP binding site [chemical binding]; other site 1114958003601 Q-loop/lid; other site 1114958003602 ABC transporter signature motif; other site 1114958003603 Walker B; other site 1114958003604 D-loop; other site 1114958003605 H-loop/switch region; other site 1114958003606 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003607 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114958003608 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1114958003609 peptide binding site [polypeptide binding]; other site 1114958003610 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1114958003611 dimer interface [polypeptide binding]; other site 1114958003612 catalytic triad [active] 1114958003613 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1114958003614 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1114958003615 active site 1114958003616 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958003617 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1114958003618 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1114958003619 Walker A/P-loop; other site 1114958003620 ATP binding site [chemical binding]; other site 1114958003621 Q-loop/lid; other site 1114958003622 ABC transporter signature motif; other site 1114958003623 Walker B; other site 1114958003624 D-loop; other site 1114958003625 H-loop/switch region; other site 1114958003626 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003627 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1114958003628 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1114958003629 Amidinotransferase; Region: Amidinotransf; cl12043 1114958003630 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1114958003631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114958003632 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958003633 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114958003634 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114958003635 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114958003636 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114958003637 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114958003638 putative active site [active] 1114958003639 putative substrate binding site [chemical binding]; other site 1114958003640 putative cosubstrate binding site; other site 1114958003641 catalytic site [active] 1114958003642 gamma-glutamyl kinase; Provisional; Region: PRK05429 1114958003643 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1114958003644 nucleotide binding site [chemical binding]; other site 1114958003645 homotetrameric interface [polypeptide binding]; other site 1114958003646 putative phosphate binding site [ion binding]; other site 1114958003647 putative allosteric binding site; other site 1114958003648 PUA domain; Region: PUA; cl00607 1114958003649 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1114958003650 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1114958003651 putative catalytic cysteine [active] 1114958003652 OsmC-like protein; Region: OsmC; cl00767 1114958003653 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958003654 Helix-turn-helix domains; Region: HTH; cl00088 1114958003655 OsmC-like protein; Region: OsmC; cl00767 1114958003656 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958003657 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1114958003658 putative metal binding site; other site 1114958003659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958003660 binding surface 1114958003661 TPR motif; other site 1114958003662 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1114958003663 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1114958003664 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1114958003665 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114958003666 ligand binding site [chemical binding]; other site 1114958003667 flexible hinge region; other site 1114958003668 Helix-turn-helix domains; Region: HTH; cl00088 1114958003669 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1114958003670 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1114958003671 THF binding site; other site 1114958003672 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1114958003673 substrate binding site [chemical binding]; other site 1114958003674 THF binding site; other site 1114958003675 zinc-binding site [ion binding]; other site 1114958003676 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1114958003677 active site 1114958003678 catalytic residues [active] 1114958003679 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958003680 Cobalt transport protein; Region: CbiQ; cl00463 1114958003681 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1114958003682 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958003683 Walker A/P-loop; other site 1114958003684 ATP binding site [chemical binding]; other site 1114958003685 Q-loop/lid; other site 1114958003686 ABC transporter signature motif; other site 1114958003687 Walker B; other site 1114958003688 D-loop; other site 1114958003689 H-loop/switch region; other site 1114958003690 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958003691 Walker A/P-loop; other site 1114958003692 ATP binding site [chemical binding]; other site 1114958003693 Q-loop/lid; other site 1114958003694 ABC transporter signature motif; other site 1114958003695 Walker B; other site 1114958003696 D-loop; other site 1114958003697 H-loop/switch region; other site 1114958003698 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1114958003699 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1114958003700 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958003701 putative peptidoglycan binding site; other site 1114958003702 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958003703 putative peptidoglycan binding site; other site 1114958003704 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1114958003705 active site 1114958003706 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1114958003707 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1114958003708 MgtE intracellular N domain; Region: MgtE_N; cl15244 1114958003709 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1114958003710 Divalent cation transporter; Region: MgtE; cl00786 1114958003711 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1114958003712 DNA binding residues [nucleotide binding] 1114958003713 putative dimer interface [polypeptide binding]; other site 1114958003714 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958003715 Helix-turn-helix domains; Region: HTH; cl00088 1114958003716 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1114958003717 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1114958003718 active site 1114958003719 DNA binding site [nucleotide binding] 1114958003720 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1114958003721 nucleotide binding site [chemical binding]; other site 1114958003722 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1114958003723 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1114958003724 putative DNA binding site [nucleotide binding]; other site 1114958003725 putative homodimer interface [polypeptide binding]; other site 1114958003726 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114958003727 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114958003728 Integral membrane protein TerC family; Region: TerC; cl10468 1114958003729 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1114958003730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958003731 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1114958003732 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1114958003733 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1114958003734 Peptidase family M48; Region: Peptidase_M48; cl12018 1114958003735 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1114958003736 Cation transport protein; Region: TrkH; cl10514 1114958003737 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114958003738 OpgC protein; Region: OpgC_C; cl00792 1114958003739 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1114958003740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958003741 PAS domain; Region: PAS_9; pfam13426 1114958003742 PAS domain; Region: PAS_9; pfam13426 1114958003743 PAS domain S-box; Region: sensory_box; TIGR00229 1114958003744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958003745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958003746 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114958003747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958003748 dimer interface [polypeptide binding]; other site 1114958003749 phosphorylation site [posttranslational modification] 1114958003750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958003751 ATP binding site [chemical binding]; other site 1114958003752 Mg2+ binding site [ion binding]; other site 1114958003753 G-X-G motif; other site 1114958003754 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114958003755 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1114958003756 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114958003757 DNA binding site [nucleotide binding] 1114958003758 active site 1114958003759 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1114958003760 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1114958003761 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958003762 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958003763 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114958003764 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1114958003765 putative active site [active] 1114958003766 catalytic triad [active] 1114958003767 putative dimer interface [polypeptide binding]; other site 1114958003768 transaminase; Reviewed; Region: PRK08068 1114958003769 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958003770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003771 homodimer interface [polypeptide binding]; other site 1114958003772 catalytic residue [active] 1114958003773 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1114958003774 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1114958003775 dimer interface [polypeptide binding]; other site 1114958003776 active site 1114958003777 catalytic residue [active] 1114958003778 metal binding site [ion binding]; metal-binding site 1114958003779 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1114958003780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958003781 motif II; other site 1114958003782 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1114958003783 intersubunit interface [polypeptide binding]; other site 1114958003784 active site 1114958003785 Zn2+ binding site [ion binding]; other site 1114958003786 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1114958003787 Cupin domain; Region: Cupin_2; cl09118 1114958003788 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1114958003789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114958003790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958003791 dimer interface [polypeptide binding]; other site 1114958003792 phosphorylation site [posttranslational modification] 1114958003793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958003794 ATP binding site [chemical binding]; other site 1114958003795 Mg2+ binding site [ion binding]; other site 1114958003796 G-X-G motif; other site 1114958003797 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958003798 Helix-turn-helix domains; Region: HTH; cl00088 1114958003799 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1114958003800 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114958003801 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114958003802 ligand binding site [chemical binding]; other site 1114958003803 flagellar motor protein MotA; Validated; Region: PRK08124 1114958003804 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114958003805 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1114958003806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958003807 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114958003808 Walker A motif; other site 1114958003809 ATP binding site [chemical binding]; other site 1114958003810 Walker B motif; other site 1114958003811 arginine finger; other site 1114958003812 excinuclease ABC, B subunit; Region: uvrb; TIGR00631 1114958003813 UvrB/uvrC motif; Region: UVR; pfam02151 1114958003814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958003815 Walker A motif; other site 1114958003816 ATP binding site [chemical binding]; other site 1114958003817 Walker B motif; other site 1114958003818 arginine finger; other site 1114958003819 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114958003820 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1114958003821 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1114958003822 Ligand Binding Site [chemical binding]; other site 1114958003823 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1114958003824 active site 1114958003825 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1114958003826 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1114958003827 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1114958003828 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1114958003829 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1114958003830 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1114958003831 MatE; Region: MatE; cl10513 1114958003832 MatE; Region: MatE; cl10513 1114958003833 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114958003834 catalytic residues [active] 1114958003835 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1114958003836 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114958003837 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958003838 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1114958003839 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114958003840 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1114958003841 active site 1114958003842 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958003843 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958003844 DNA binding site [nucleotide binding] 1114958003845 domain linker motif; other site 1114958003846 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1114958003847 putative dimerization interface [polypeptide binding]; other site 1114958003848 putative ligand binding site [chemical binding]; other site 1114958003849 CAT RNA binding domain; Region: CAT_RBD; cl03904 1114958003850 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1114958003851 PRD domain; Region: PRD; cl15445 1114958003852 PRD domain; Region: PRD; cl15445 1114958003853 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1114958003854 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958003855 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958003856 active site turn [active] 1114958003857 phosphorylation site [posttranslational modification] 1114958003858 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1114958003859 HPr interaction site; other site 1114958003860 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114958003861 active site 1114958003862 phosphorylation site [posttranslational modification] 1114958003863 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114958003864 dimerization domain swap beta strand [polypeptide binding]; other site 1114958003865 regulatory protein interface [polypeptide binding]; other site 1114958003866 active site 1114958003867 regulatory phosphorylation site [posttranslational modification]; other site 1114958003868 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 1114958003869 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114958003870 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114958003871 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1114958003872 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1114958003873 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1114958003874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958003875 FeS/SAM binding site; other site 1114958003876 two component system sensor kinase SsrA; Provisional; Region: PRK15347 1114958003877 Cache domain; Region: Cache_1; pfam02743 1114958003878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958003879 dimerization interface [polypeptide binding]; other site 1114958003880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958003881 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958003882 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958003883 dimer interface [polypeptide binding]; other site 1114958003884 putative CheW interface [polypeptide binding]; other site 1114958003885 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1114958003886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003887 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1114958003888 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114958003889 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958003890 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958003891 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958003892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958003893 putative active site [active] 1114958003894 heme pocket [chemical binding]; other site 1114958003895 PAS fold; Region: PAS; pfam00989 1114958003896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958003897 putative active site [active] 1114958003898 heme pocket [chemical binding]; other site 1114958003899 PAS fold; Region: PAS; pfam00989 1114958003900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958003901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114958003902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958003903 dimer interface [polypeptide binding]; other site 1114958003904 phosphorylation site [posttranslational modification] 1114958003905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958003906 ATP binding site [chemical binding]; other site 1114958003907 Mg2+ binding site [ion binding]; other site 1114958003908 G-X-G motif; other site 1114958003909 aminotransferase A; Validated; Region: PRK07683 1114958003910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958003911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003912 homodimer interface [polypeptide binding]; other site 1114958003913 catalytic residue [active] 1114958003914 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114958003915 putative CheA interaction surface; other site 1114958003916 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958003917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958003918 active site 1114958003919 phosphorylation site [posttranslational modification] 1114958003920 intermolecular recognition site; other site 1114958003921 dimerization interface [polypeptide binding]; other site 1114958003922 YkyB-like protein; Region: YkyB; pfam14177 1114958003923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003924 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958003925 putative substrate translocation pore; other site 1114958003926 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958003927 putative peptidoglycan binding site; other site 1114958003928 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1114958003929 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1114958003930 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958003931 putative active site [active] 1114958003932 putative metal binding site [ion binding]; other site 1114958003933 short chain dehydrogenase; Provisional; Region: PRK07677 1114958003934 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1114958003935 NAD(P) binding site [chemical binding]; other site 1114958003936 substrate binding site [chemical binding]; other site 1114958003937 homotetramer interface [polypeptide binding]; other site 1114958003938 active site 1114958003939 homodimer interface [polypeptide binding]; other site 1114958003940 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114958003941 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1114958003942 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1114958003943 Protein of unknown function (DUF458); Region: DUF458; cl00861 1114958003944 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1114958003945 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958003946 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1114958003947 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958003948 Helix-turn-helix domains; Region: HTH; cl00088 1114958003949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958003950 dimerization interface [polypeptide binding]; other site 1114958003951 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958003952 BNR repeat-like domain; Region: BNR_2; pfam13088 1114958003953 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958003954 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1114958003955 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1114958003956 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1114958003957 active site 1114958003958 trimer interface [polypeptide binding]; other site 1114958003959 substrate binding site [chemical binding]; other site 1114958003960 CoA binding site [chemical binding]; other site 1114958003961 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1114958003962 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1114958003963 metal binding site [ion binding]; metal-binding site 1114958003964 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 1114958003965 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114958003966 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114958003967 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114958003968 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1114958003969 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1114958003970 GTP binding site; other site 1114958003971 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1114958003972 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114958003973 ATP binding site [chemical binding]; other site 1114958003974 substrate interface [chemical binding]; other site 1114958003975 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114958003976 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114958003977 dimer interface [polypeptide binding]; other site 1114958003978 putative functional site; other site 1114958003979 putative MPT binding site; other site 1114958003980 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1114958003981 Walker A motif; other site 1114958003982 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1114958003983 MoaE homodimer interface [polypeptide binding]; other site 1114958003984 MoaD interaction [polypeptide binding]; other site 1114958003985 active site residues [active] 1114958003986 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1114958003987 MoaE interaction surface [polypeptide binding]; other site 1114958003988 MoeB interaction surface [polypeptide binding]; other site 1114958003989 thiocarboxylated glycine; other site 1114958003990 Yip1 domain; Region: Yip1; cl12048 1114958003991 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114958003992 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1114958003993 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958003994 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114958003995 Walker A/P-loop; other site 1114958003996 ATP binding site [chemical binding]; other site 1114958003997 Q-loop/lid; other site 1114958003998 ABC transporter signature motif; other site 1114958003999 Walker B; other site 1114958004000 D-loop; other site 1114958004001 H-loop/switch region; other site 1114958004002 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114958004003 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1114958004004 FtsX-like permease family; Region: FtsX; cl15850 1114958004005 Helix-turn-helix domains; Region: HTH; cl00088 1114958004006 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114958004007 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1114958004008 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1114958004009 putative substrate binding site [chemical binding]; other site 1114958004010 putative ATP binding site [chemical binding]; other site 1114958004011 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1114958004012 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958004013 active site 1114958004014 phosphorylation site [posttranslational modification] 1114958004015 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114958004016 active site 1114958004017 P-loop; other site 1114958004018 phosphorylation site [posttranslational modification] 1114958004019 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958004020 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114958004021 Catalytic site [active] 1114958004022 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1114958004023 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958004024 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958004025 ABC transporter; Region: ABC_tran_2; pfam12848 1114958004026 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958004027 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1114958004028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004029 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114958004030 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1114958004031 rod-share determining protein MreBH; Provisional; Region: PRK13929 1114958004032 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1114958004033 ATP binding site [chemical binding]; other site 1114958004034 profilin binding site; other site 1114958004035 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1114958004036 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1114958004037 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1114958004038 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114958004039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958004040 putative active site [active] 1114958004041 heme pocket [chemical binding]; other site 1114958004042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114958004043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958004044 ATP binding site [chemical binding]; other site 1114958004045 Mg2+ binding site [ion binding]; other site 1114958004046 G-X-G motif; other site 1114958004047 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1114958004048 putative active site pocket [active] 1114958004049 dimerization interface [polypeptide binding]; other site 1114958004050 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1114958004051 putative active site pocket [active] 1114958004052 dimerization interface [polypeptide binding]; other site 1114958004053 putative catalytic residue [active] 1114958004054 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114958004055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004056 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114958004057 adenine deaminase; Region: ade; TIGR01178 1114958004058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958004059 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1114958004060 active site 1114958004061 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958004062 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1114958004063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958004064 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1114958004065 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 1114958004066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958004067 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958004068 active site 1114958004069 motif I; other site 1114958004070 motif II; other site 1114958004071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958004072 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114958004073 active site 1114958004074 catalytic residues [active] 1114958004075 metal binding site [ion binding]; metal-binding site 1114958004076 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1114958004077 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114958004078 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958004079 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1114958004080 FMN binding site [chemical binding]; other site 1114958004081 substrate binding site [chemical binding]; other site 1114958004082 putative catalytic residue [active] 1114958004083 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004084 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004085 active site 1114958004086 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004087 putative NADP binding site [chemical binding]; other site 1114958004088 active site 1114958004089 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004090 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004091 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004092 active site 1114958004093 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958004094 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004095 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004096 putative NADP binding site [chemical binding]; other site 1114958004097 active site 1114958004098 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004099 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004100 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1114958004101 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004102 active site 1114958004103 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958004104 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004105 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004106 putative NADP binding site [chemical binding]; other site 1114958004107 active site 1114958004108 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004109 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004110 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004111 active site 1114958004112 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958004113 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004114 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004115 putative NADP binding site [chemical binding]; other site 1114958004116 active site 1114958004117 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004118 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004119 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004120 active site 1114958004121 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004122 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004123 putative NADP binding site [chemical binding]; other site 1114958004124 active site 1114958004125 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004126 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004127 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1114958004128 active site 1114958004129 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004130 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958004131 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004132 putative NADP binding site [chemical binding]; other site 1114958004133 active site 1114958004134 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004135 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004136 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004137 active site 1114958004138 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958004139 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004140 putative NADP binding site [chemical binding]; other site 1114958004141 active site 1114958004142 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004143 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004144 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004145 active site 1114958004146 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004147 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004148 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004149 putative NADP binding site [chemical binding]; other site 1114958004150 active site 1114958004151 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004152 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004153 active site 1114958004154 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958004155 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004156 putative NADP binding site [chemical binding]; other site 1114958004157 active site 1114958004158 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004159 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004160 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004161 active site 1114958004162 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004163 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958004164 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004165 putative NADP binding site [chemical binding]; other site 1114958004166 active site 1114958004167 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004168 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004169 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004170 active site 1114958004171 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004172 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004173 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004174 putative NADP binding site [chemical binding]; other site 1114958004175 active site 1114958004176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958004177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958004178 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1114958004179 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114958004180 TPP-binding site [chemical binding]; other site 1114958004181 tetramer interface [polypeptide binding]; other site 1114958004182 heterodimer interface [polypeptide binding]; other site 1114958004183 phosphorylation loop region [posttranslational modification] 1114958004184 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114958004185 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114958004186 alpha subunit interface [polypeptide binding]; other site 1114958004187 TPP binding site [chemical binding]; other site 1114958004188 heterodimer interface [polypeptide binding]; other site 1114958004189 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958004190 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114958004191 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114958004192 E3 interaction surface; other site 1114958004193 lipoyl attachment site [posttranslational modification]; other site 1114958004194 e3 binding domain; Region: E3_binding; pfam02817 1114958004195 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1114958004196 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1114958004197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958004199 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114958004200 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114958004201 NodB motif; other site 1114958004202 active site 1114958004203 catalytic site [active] 1114958004204 metal binding site [ion binding]; metal-binding site 1114958004205 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1114958004206 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1114958004207 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1114958004208 homodimer interface [polypeptide binding]; other site 1114958004209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958004210 catalytic residue [active] 1114958004211 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1114958004212 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1114958004213 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 1114958004214 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1114958004215 active site 1114958004216 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1114958004217 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958004218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958004219 Coenzyme A binding pocket [chemical binding]; other site 1114958004220 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1114958004221 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1114958004222 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1114958004223 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1114958004224 active site 1114958004225 Zn binding site [ion binding]; other site 1114958004226 Predicted integral membrane protein [Function unknown]; Region: COG5660 1114958004227 Putative zinc-finger; Region: zf-HC2; cl15806 1114958004228 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1114958004229 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1114958004230 G1 box; other site 1114958004231 putative GEF interaction site [polypeptide binding]; other site 1114958004232 GTP/Mg2+ binding site [chemical binding]; other site 1114958004233 Switch I region; other site 1114958004234 G2 box; other site 1114958004235 G3 box; other site 1114958004236 Switch II region; other site 1114958004237 G4 box; other site 1114958004238 G5 box; other site 1114958004239 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1114958004240 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1114958004241 YlaH-like protein; Region: YlaH; pfam14036 1114958004242 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 1114958004243 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1114958004244 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1114958004245 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1114958004246 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1114958004247 putative active site [active] 1114958004248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958004249 Glutaminase; Region: Glutaminase; cl00907 1114958004250 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 1114958004251 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1114958004252 pyruvate carboxylase; Reviewed; Region: PRK12999 1114958004253 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958004254 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958004255 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114958004256 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1114958004257 active site 1114958004258 catalytic residues [active] 1114958004259 metal binding site [ion binding]; metal-binding site 1114958004260 homodimer binding site [polypeptide binding]; other site 1114958004261 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114958004262 carboxyltransferase (CT) interaction site; other site 1114958004263 biotinylation site [posttranslational modification]; other site 1114958004264 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1114958004265 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1114958004266 UbiA prenyltransferase family; Region: UbiA; cl00337 1114958004267 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1114958004268 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1114958004269 Cytochrome c; Region: Cytochrom_C; cl11414 1114958004270 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114958004271 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1114958004272 D-pathway; other site 1114958004273 Putative ubiquinol binding site [chemical binding]; other site 1114958004274 Low-spin heme (heme b) binding site [chemical binding]; other site 1114958004275 Putative water exit pathway; other site 1114958004276 Binuclear center (heme o3/CuB) [ion binding]; other site 1114958004277 K-pathway; other site 1114958004278 Putative proton exit pathway; other site 1114958004279 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1114958004280 Subunit I/III interface [polypeptide binding]; other site 1114958004281 Subunit III/IV interface [polypeptide binding]; other site 1114958004282 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1114958004283 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1114958004284 YugN-like family; Region: YugN; pfam08868 1114958004285 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958004286 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1114958004287 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1114958004288 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1114958004289 Putative coat protein; Region: YlbD_coat; pfam14071 1114958004290 YlbE-like protein; Region: YlbE; pfam14003 1114958004291 Protein of unknown function (DUF964); Region: DUF964; cl01483 1114958004292 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1114958004293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958004294 S-adenosylmethionine binding site [chemical binding]; other site 1114958004295 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1114958004296 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1114958004297 active site 1114958004298 (T/H)XGH motif; other site 1114958004299 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1114958004300 Nucleoside recognition; Region: Gate; cl00486 1114958004301 Nucleoside recognition; Region: Gate; cl00486 1114958004302 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114958004303 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1114958004304 active site 1114958004305 nucleophile elbow; other site 1114958004306 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1114958004307 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1114958004308 protein binding site [polypeptide binding]; other site 1114958004309 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114958004310 hypothetical protein; Provisional; Region: PRK13670 1114958004311 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114958004312 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1114958004313 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1114958004314 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1114958004315 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1114958004316 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958004317 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1114958004318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004319 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114958004320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1114958004321 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1114958004322 mraZ protein; Region: TIGR00242 1114958004323 MraZ protein; Region: MraZ; pfam02381 1114958004324 MraZ protein; Region: MraZ; pfam02381 1114958004325 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1114958004326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958004327 Septum formation initiator; Region: DivIC; cl11433 1114958004328 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114958004329 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958004330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958004331 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1114958004332 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1114958004333 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1114958004334 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958004335 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958004336 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1114958004337 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1114958004338 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114958004339 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958004340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958004341 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1114958004342 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1114958004343 Mg++ binding site [ion binding]; other site 1114958004344 putative catalytic motif [active] 1114958004345 putative substrate binding site [chemical binding]; other site 1114958004346 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1114958004347 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958004348 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958004349 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1114958004350 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1114958004351 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1114958004352 active site 1114958004353 homodimer interface [polypeptide binding]; other site 1114958004354 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1114958004355 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958004356 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1114958004357 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1114958004358 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1114958004359 Cell division protein FtsQ; Region: FtsQ; pfam03799 1114958004360 cell division protein FtsA; Region: ftsA; TIGR01174 1114958004361 Cell division protein FtsA; Region: FtsA; cl11496 1114958004362 Cell division protein FtsA; Region: FtsA; cl11496 1114958004363 cell division protein FtsZ; Validated; Region: PRK09330 1114958004364 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1114958004365 nucleotide binding site [chemical binding]; other site 1114958004366 SulA interaction site; other site 1114958004367 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1114958004368 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1114958004369 active site 1114958004370 catalytic triad [active] 1114958004371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1114958004372 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1114958004373 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958004374 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1114958004375 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1114958004376 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1114958004377 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1114958004378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958004379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958004380 DNA binding residues [nucleotide binding] 1114958004381 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1114958004382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958004383 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958004384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958004385 DNA binding residues [nucleotide binding] 1114958004386 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114958004387 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958004388 Walker A/P-loop; other site 1114958004389 ATP binding site [chemical binding]; other site 1114958004390 Q-loop/lid; other site 1114958004391 ABC transporter signature motif; other site 1114958004392 Walker B; other site 1114958004393 D-loop; other site 1114958004394 H-loop/switch region; other site 1114958004395 acetylornithine deacetylase; Validated; Region: PRK08596 1114958004396 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1114958004397 metal binding site [ion binding]; metal-binding site 1114958004398 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1114958004399 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1114958004400 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1114958004401 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1114958004402 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114958004403 catalytic residue [active] 1114958004404 Protein of unknown function (DUF552); Region: DUF552; cl00775 1114958004405 YGGT family; Region: YGGT; cl00508 1114958004406 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1114958004407 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958004408 RNA binding surface [nucleotide binding]; other site 1114958004409 DivIVA protein; Region: DivIVA; pfam05103 1114958004410 DivIVA domain; Region: DivI1A_domain; TIGR03544 1114958004411 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1114958004412 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1114958004413 HIGH motif; other site 1114958004414 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114958004415 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1114958004416 active site 1114958004417 KMSKS motif; other site 1114958004418 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1114958004419 tRNA binding surface [nucleotide binding]; other site 1114958004420 anticodon binding site; other site 1114958004421 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1114958004422 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1114958004423 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1114958004424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958004425 RNA binding surface [nucleotide binding]; other site 1114958004426 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114958004427 active site 1114958004428 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958004429 active site 1114958004430 uracil-xanthine permease; Region: ncs2; TIGR00801 1114958004431 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1114958004432 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114958004433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004434 dihydroorotase; Validated; Region: pyrC; PRK09357 1114958004435 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958004436 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1114958004437 active site 1114958004438 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1114958004439 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1114958004440 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1114958004441 catalytic site [active] 1114958004442 subunit interface [polypeptide binding]; other site 1114958004443 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1114958004444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958004445 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958004446 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1114958004447 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958004448 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958004449 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1114958004450 IMP binding site; other site 1114958004451 dimer interface [polypeptide binding]; other site 1114958004452 interdomain contacts; other site 1114958004453 partial ornithine binding site; other site 1114958004454 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1114958004455 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1114958004456 FAD binding pocket [chemical binding]; other site 1114958004457 FAD binding motif [chemical binding]; other site 1114958004458 phosphate binding motif [ion binding]; other site 1114958004459 beta-alpha-beta structure motif; other site 1114958004460 NAD binding pocket [chemical binding]; other site 1114958004461 Iron coordination center [ion binding]; other site 1114958004462 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1114958004463 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1114958004464 heterodimer interface [polypeptide binding]; other site 1114958004465 active site 1114958004466 FMN binding site [chemical binding]; other site 1114958004467 homodimer interface [polypeptide binding]; other site 1114958004468 substrate binding site [chemical binding]; other site 1114958004469 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1114958004470 active site 1114958004471 dimer interface [polypeptide binding]; other site 1114958004472 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 1114958004473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958004474 active site 1114958004475 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1114958004476 Active Sites [active] 1114958004477 Phosphate transporter family; Region: PHO4; cl00396 1114958004478 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1114958004479 ATP-sulfurylase; Region: ATPS; cd00517 1114958004480 active site 1114958004481 HXXH motif; other site 1114958004482 flexible loop; other site 1114958004483 AAA domain; Region: AAA_33; pfam13671 1114958004484 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1114958004485 ligand-binding site [chemical binding]; other site 1114958004486 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1114958004487 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1114958004488 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1114958004489 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1114958004490 putative active site [active] 1114958004491 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1114958004492 putative active site [active] 1114958004493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004494 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1114958004495 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1114958004496 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1114958004497 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1114958004498 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114958004499 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1114958004500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958004501 motif II; other site 1114958004502 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1114958004503 TIGR00255 family protein; Region: TIGR00255 1114958004504 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1114958004505 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1114958004506 Domain of unknown function (DUF370); Region: DUF370; cl00898 1114958004507 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1114958004508 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1114958004509 catalytic site [active] 1114958004510 G-X2-G-X-G-K; other site 1114958004511 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1114958004512 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1114958004513 Flavoprotein; Region: Flavoprotein; cl08021 1114958004514 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1114958004515 primosome assembly protein PriA; Validated; Region: PRK05580 1114958004516 primosome assembly protein PriA; Validated; Region: PRK05580 1114958004517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958004518 ATP binding site [chemical binding]; other site 1114958004519 putative Mg++ binding site [ion binding]; other site 1114958004520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958004521 nucleotide binding region [chemical binding]; other site 1114958004522 ATP-binding site [chemical binding]; other site 1114958004523 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114958004524 active site 1114958004525 catalytic residues [active] 1114958004526 metal binding site [ion binding]; metal-binding site 1114958004527 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1114958004528 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1114958004529 putative active site [active] 1114958004530 substrate binding site [chemical binding]; other site 1114958004531 putative cosubstrate binding site; other site 1114958004532 catalytic site [active] 1114958004533 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1114958004534 substrate binding site [chemical binding]; other site 1114958004535 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1114958004536 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1114958004537 putative RNA binding site [nucleotide binding]; other site 1114958004538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958004539 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1114958004540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958004541 FeS/SAM binding site; other site 1114958004542 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114958004543 Protein phosphatase 2C; Region: PP2C; pfam00481 1114958004544 active site 1114958004545 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114958004546 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114958004547 active site 1114958004548 ATP binding site [chemical binding]; other site 1114958004549 substrate binding site [chemical binding]; other site 1114958004550 activation loop (A-loop); other site 1114958004551 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958004552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1114958004553 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114958004554 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114958004555 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114958004556 GTPase RsgA; Reviewed; Region: PRK00098 1114958004557 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1114958004558 RNA binding site [nucleotide binding]; other site 1114958004559 homodimer interface [polypeptide binding]; other site 1114958004560 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1114958004561 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1114958004562 GTP/Mg2+ binding site [chemical binding]; other site 1114958004563 G4 box; other site 1114958004564 G5 box; other site 1114958004565 G1 box; other site 1114958004566 Switch I region; other site 1114958004567 G2 box; other site 1114958004568 G3 box; other site 1114958004569 Switch II region; other site 1114958004570 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1114958004571 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1114958004572 substrate binding site [chemical binding]; other site 1114958004573 hexamer interface [polypeptide binding]; other site 1114958004574 metal binding site [ion binding]; metal-binding site 1114958004575 Thiamine pyrophosphokinase; Region: TPK; cd07995 1114958004576 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1114958004577 active site 1114958004578 dimerization interface [polypeptide binding]; other site 1114958004579 thiamine binding site [chemical binding]; other site 1114958004580 Stage V sporulation protein family; Region: SpoV; cl15455 1114958004581 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1114958004582 Asp23 family; Region: Asp23; cl00574 1114958004583 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1114958004584 DAK2 domain; Region: Dak2; cl03685 1114958004585 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1114958004586 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1114958004587 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1114958004588 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1114958004589 putative L-serine binding site [chemical binding]; other site 1114958004590 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1114958004591 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1114958004592 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1114958004593 Y-family of DNA polymerases; Region: PolY; cl12025 1114958004594 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1114958004595 generic binding surface II; other site 1114958004596 ssDNA binding site; other site 1114958004597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958004598 ATP binding site [chemical binding]; other site 1114958004599 putative Mg++ binding site [ion binding]; other site 1114958004600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958004601 nucleotide binding region [chemical binding]; other site 1114958004602 ATP-binding site [chemical binding]; other site 1114958004603 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1114958004604 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114958004605 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1114958004606 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114958004607 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958004608 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1114958004609 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1114958004610 NAD(P) binding site [chemical binding]; other site 1114958004611 homotetramer interface [polypeptide binding]; other site 1114958004612 homodimer interface [polypeptide binding]; other site 1114958004613 active site 1114958004614 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958004615 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1114958004616 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1114958004617 dimerization interface [polypeptide binding]; other site 1114958004618 active site 1114958004619 metal binding site [ion binding]; metal-binding site 1114958004620 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1114958004621 dsRNA binding site [nucleotide binding]; other site 1114958004622 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114958004623 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1114958004624 Walker A/P-loop; other site 1114958004625 ATP binding site [chemical binding]; other site 1114958004626 Q-loop/lid; other site 1114958004627 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1114958004628 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1114958004629 Q-loop/lid; other site 1114958004630 ABC transporter signature motif; other site 1114958004631 Walker B; other site 1114958004632 D-loop; other site 1114958004633 H-loop/switch region; other site 1114958004634 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1114958004635 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1114958004636 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114958004637 GTP binding site [chemical binding]; other site 1114958004638 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958004639 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958004640 active site 1114958004641 ATP binding site [chemical binding]; other site 1114958004642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958004643 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1114958004644 signal recognition particle protein; Provisional; Region: PRK10867 1114958004645 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1114958004646 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114958004647 P loop; other site 1114958004648 GTP binding site [chemical binding]; other site 1114958004649 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1114958004650 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1114958004651 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1114958004652 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1114958004653 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1114958004654 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1114958004655 RimM N-terminal domain; Region: RimM; pfam01782 1114958004656 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1114958004657 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1114958004658 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1114958004659 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1114958004660 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1114958004661 GTP/Mg2+ binding site [chemical binding]; other site 1114958004662 G4 box; other site 1114958004663 G5 box; other site 1114958004664 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1114958004665 G1 box; other site 1114958004666 G1 box; other site 1114958004667 GTP/Mg2+ binding site [chemical binding]; other site 1114958004668 Switch I region; other site 1114958004669 G2 box; other site 1114958004670 G2 box; other site 1114958004671 G3 box; other site 1114958004672 G3 box; other site 1114958004673 Switch II region; other site 1114958004674 Switch II region; other site 1114958004675 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1114958004676 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114958004677 active site 1114958004678 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1114958004679 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1114958004680 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958004681 CoA-ligase; Region: Ligase_CoA; cl02894 1114958004682 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1114958004683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004684 CoA-ligase; Region: Ligase_CoA; cl02894 1114958004685 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114958004686 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1114958004687 DNA topoisomerase I; Validated; Region: PRK05582 1114958004688 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1114958004689 active site 1114958004690 interdomain interaction site; other site 1114958004691 putative metal-binding site [ion binding]; other site 1114958004692 nucleotide binding site [chemical binding]; other site 1114958004693 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114958004694 domain I; other site 1114958004695 DNA binding groove [nucleotide binding] 1114958004696 phosphate binding site [ion binding]; other site 1114958004697 domain II; other site 1114958004698 domain III; other site 1114958004699 nucleotide binding site [chemical binding]; other site 1114958004700 catalytic site [active] 1114958004701 domain IV; other site 1114958004702 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114958004703 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114958004704 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1114958004705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004706 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1114958004707 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1114958004708 active site 1114958004709 Int/Topo IB signature motif; other site 1114958004710 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1114958004711 active site 1114958004712 HslU subunit interaction site [polypeptide binding]; other site 1114958004713 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1114958004714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958004715 Walker A motif; other site 1114958004716 ATP binding site [chemical binding]; other site 1114958004717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958004718 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114958004719 transcriptional repressor CodY; Validated; Region: PRK04158 1114958004720 CodY GAF-like domain; Region: CodY; pfam06018 1114958004721 Helix-turn-helix domains; Region: HTH; cl00088 1114958004722 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1114958004723 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 1114958004724 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 1114958004725 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1114958004726 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 1114958004727 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114958004728 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1114958004729 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1114958004730 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1114958004731 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1114958004732 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1114958004733 MgtE intracellular N domain; Region: MgtE_N; cl15244 1114958004734 FliG C-terminal domain; Region: FliG_C; pfam01706 1114958004735 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1114958004736 Flagellar assembly protein FliH; Region: FliH; pfam02108 1114958004737 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1114958004738 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1114958004739 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1114958004740 Walker A motif/ATP binding site; other site 1114958004741 Walker B motif; other site 1114958004742 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 1114958004743 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1114958004744 MgtE intracellular N domain; Region: MgtE_N; cl15244 1114958004745 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1114958004746 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 1114958004747 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1114958004748 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1114958004749 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1114958004750 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 1114958004751 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114958004752 Flagellar protein (FlbD); Region: FlbD; cl00683 1114958004753 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1114958004754 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1114958004755 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114958004756 flagellar motor switch protein; Validated; Region: PRK08119 1114958004757 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1114958004758 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1114958004759 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114958004760 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958004761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958004762 active site 1114958004763 phosphorylation site [posttranslational modification] 1114958004764 intermolecular recognition site; other site 1114958004765 dimerization interface [polypeptide binding]; other site 1114958004766 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1114958004767 FliP family; Region: FliP; cl00593 1114958004768 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1114958004769 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1114958004770 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1114958004771 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1114958004772 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1114958004773 FHIPEP family; Region: FHIPEP; pfam00771 1114958004774 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1114958004775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958004776 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1114958004777 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1114958004778 P-loop; other site 1114958004779 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1114958004780 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1114958004781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958004782 active site 1114958004783 phosphorylation site [posttranslational modification] 1114958004784 intermolecular recognition site; other site 1114958004785 dimerization interface [polypeptide binding]; other site 1114958004786 CheB methylesterase; Region: CheB_methylest; pfam01339 1114958004787 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114958004788 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114958004789 putative binding surface; other site 1114958004790 active site 1114958004791 P2 response regulator binding domain; Region: P2; pfam07194 1114958004792 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114958004793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958004794 ATP binding site [chemical binding]; other site 1114958004795 Mg2+ binding site [ion binding]; other site 1114958004796 G-X-G motif; other site 1114958004797 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114958004798 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114958004799 putative CheA interaction surface; other site 1114958004800 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1114958004801 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1114958004802 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1114958004803 CheD chemotactic sensory transduction; Region: CheD; cl00810 1114958004804 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1114958004805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958004806 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958004807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958004808 DNA binding residues [nucleotide binding] 1114958004809 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1114958004810 rRNA interaction site [nucleotide binding]; other site 1114958004811 S8 interaction site; other site 1114958004812 putative laminin-1 binding site; other site 1114958004813 elongation factor Ts; Provisional; Region: tsf; PRK09377 1114958004814 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1114958004815 Elongation factor TS; Region: EF_TS; pfam00889 1114958004816 Elongation factor TS; Region: EF_TS; pfam00889 1114958004817 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1114958004818 putative nucleotide binding site [chemical binding]; other site 1114958004819 uridine monophosphate binding site [chemical binding]; other site 1114958004820 homohexameric interface [polypeptide binding]; other site 1114958004821 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1114958004822 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1114958004823 hinge region; other site 1114958004824 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1114958004825 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1114958004826 catalytic residue [active] 1114958004827 putative FPP diphosphate binding site; other site 1114958004828 putative FPP binding hydrophobic cleft; other site 1114958004829 dimer interface [polypeptide binding]; other site 1114958004830 putative IPP diphosphate binding site; other site 1114958004831 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1114958004832 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1114958004833 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1114958004834 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1114958004835 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1114958004836 RIP metalloprotease RseP; Region: TIGR00054 1114958004837 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114958004838 active site 1114958004839 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1114958004840 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114958004841 protein binding site [polypeptide binding]; other site 1114958004842 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114958004843 putative substrate binding region [chemical binding]; other site 1114958004844 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1114958004845 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 1114958004846 dimer interface [polypeptide binding]; other site 1114958004847 motif 1; other site 1114958004848 active site 1114958004849 motif 2; other site 1114958004850 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1114958004851 putative deacylase active site [active] 1114958004852 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1114958004853 active site 1114958004854 motif 3; other site 1114958004855 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1114958004856 anticodon binding site; other site 1114958004857 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1114958004858 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1114958004859 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1114958004860 generic binding surface II; other site 1114958004861 generic binding surface I; other site 1114958004862 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114958004863 active site 1114958004864 catalytic site [active] 1114958004865 substrate binding site [chemical binding]; other site 1114958004866 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1114958004867 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1114958004868 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1114958004869 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 1114958004870 Sm1 motif; other site 1114958004871 predicted subunit interaction site [polypeptide binding]; other site 1114958004872 RNA binding pocket [nucleotide binding]; other site 1114958004873 Sm2 motif; other site 1114958004874 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1114958004875 NusA N-terminal domain; Region: NusA_N; pfam08529 1114958004876 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1114958004877 RNA binding site [nucleotide binding]; other site 1114958004878 homodimer interface [polypeptide binding]; other site 1114958004879 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1114958004880 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1114958004881 G-X-X-G motif; other site 1114958004882 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1114958004883 putative RNA binding cleft [nucleotide binding]; other site 1114958004884 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1114958004885 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114958004886 translation initiation factor IF-2; Region: IF-2; TIGR00487 1114958004887 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114958004888 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1114958004889 G1 box; other site 1114958004890 putative GEF interaction site [polypeptide binding]; other site 1114958004891 GTP/Mg2+ binding site [chemical binding]; other site 1114958004892 Switch I region; other site 1114958004893 G2 box; other site 1114958004894 G3 box; other site 1114958004895 Switch II region; other site 1114958004896 G4 box; other site 1114958004897 G5 box; other site 1114958004898 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1114958004899 Translation-initiation factor 2; Region: IF-2; pfam11987 1114958004900 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1114958004901 Protein of unknown function (DUF503); Region: DUF503; cl00669 1114958004902 Ribosome-binding factor A; Region: RBFA; cl00542 1114958004903 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1114958004904 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1114958004905 RNA binding site [nucleotide binding]; other site 1114958004906 active site 1114958004907 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1114958004908 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1114958004909 active site 1114958004910 Riboflavin kinase; Region: Flavokinase; cl03312 1114958004911 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1114958004912 16S/18S rRNA binding site [nucleotide binding]; other site 1114958004913 S13e-L30e interaction site [polypeptide binding]; other site 1114958004914 25S rRNA binding site [nucleotide binding]; other site 1114958004915 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1114958004916 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1114958004917 RNase E interface [polypeptide binding]; other site 1114958004918 trimer interface [polypeptide binding]; other site 1114958004919 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1114958004920 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1114958004921 RNase E interface [polypeptide binding]; other site 1114958004922 trimer interface [polypeptide binding]; other site 1114958004923 active site 1114958004924 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1114958004925 putative nucleic acid binding region [nucleotide binding]; other site 1114958004926 G-X-X-G motif; other site 1114958004927 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1114958004928 RNA binding site [nucleotide binding]; other site 1114958004929 domain interface; other site 1114958004930 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1114958004931 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1114958004932 NodB motif; other site 1114958004933 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114958004934 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114958004935 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114958004936 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1114958004937 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1114958004938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004939 Flavoprotein; Region: Flavoprotein; cl08021 1114958004940 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1114958004941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958004942 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114958004943 aspartate kinase I; Reviewed; Region: PRK08210 1114958004944 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1114958004945 putative catalytic residues [active] 1114958004946 putative nucleotide binding site [chemical binding]; other site 1114958004947 putative aspartate binding site [chemical binding]; other site 1114958004948 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1114958004949 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1114958004950 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1114958004951 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1114958004952 dimer interface [polypeptide binding]; other site 1114958004953 active site 1114958004954 catalytic residue [active] 1114958004955 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1114958004956 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958004957 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1114958004958 Clp protease; Region: CLP_protease; pfam00574 1114958004959 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1114958004960 active site 1114958004961 YlzJ-like protein; Region: YlzJ; pfam14035 1114958004962 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1114958004963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958004964 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1114958004965 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114958004966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958004967 DNA-binding site [nucleotide binding]; DNA binding site 1114958004968 UTRA domain; Region: UTRA; cl01230 1114958004969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958004970 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958004971 putative substrate translocation pore; other site 1114958004972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958004973 Helix-turn-helix domains; Region: HTH; cl00088 1114958004974 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1114958004975 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1114958004976 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1114958004977 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114958004978 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114958004979 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114958004980 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114958004981 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114958004982 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1114958004983 classical (c) SDRs; Region: SDR_c; cd05233 1114958004984 NAD(P) binding site [chemical binding]; other site 1114958004985 active site 1114958004986 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1114958004987 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114958004988 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1114958004989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958004990 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1114958004991 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1114958004992 competence damage-inducible protein A; Provisional; Region: PRK00549 1114958004993 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1114958004994 putative MPT binding site; other site 1114958004995 Competence-damaged protein; Region: CinA; cl00666 1114958004996 recombinase A; Provisional; Region: recA; PRK09354 1114958004997 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1114958004998 hexamer interface [polypeptide binding]; other site 1114958004999 Walker A motif; other site 1114958005000 ATP binding site [chemical binding]; other site 1114958005001 Walker B motif; other site 1114958005002 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958005003 phosphodiesterase; Provisional; Region: PRK12704 1114958005004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114958005005 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1114958005006 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958005007 putative active site [active] 1114958005008 metal binding site [ion binding]; metal-binding site 1114958005009 homodimer binding site [polypeptide binding]; other site 1114958005010 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 1114958005011 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958005012 NAD(P) binding site [chemical binding]; other site 1114958005013 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958005014 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114958005015 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1114958005016 substrate-cofactor binding pocket; other site 1114958005017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005018 catalytic residue [active] 1114958005019 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1114958005020 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114958005021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958005022 FeS/SAM binding site; other site 1114958005023 TRAM domain; Region: TRAM; cl01282 1114958005024 Protein of unknown function (DUF964); Region: DUF964; cl01483 1114958005025 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1114958005026 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1114958005027 MutS domain I; Region: MutS_I; pfam01624 1114958005028 MutS domain II; Region: MutS_II; pfam05188 1114958005029 MutS family domain IV; Region: MutS_IV; pfam05190 1114958005030 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 1114958005031 Walker A/P-loop; other site 1114958005032 ATP binding site [chemical binding]; other site 1114958005033 Q-loop/lid; other site 1114958005034 ABC transporter signature motif; other site 1114958005035 Walker B; other site 1114958005036 D-loop; other site 1114958005037 H-loop/switch region; other site 1114958005038 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1114958005039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958005040 ATP binding site [chemical binding]; other site 1114958005041 Mg2+ binding site [ion binding]; other site 1114958005042 G-X-G motif; other site 1114958005043 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1114958005044 ATP binding site [chemical binding]; other site 1114958005045 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 1114958005046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958005047 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114958005048 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958005049 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958005050 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114958005051 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114958005052 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958005053 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1114958005054 FMN binding site [chemical binding]; other site 1114958005055 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1114958005056 substrate binding site [chemical binding]; other site 1114958005057 putative catalytic residue [active] 1114958005058 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005059 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1114958005060 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 1114958005061 dimer interface [polypeptide binding]; other site 1114958005062 active site 1114958005063 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958005064 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114958005065 substrate binding site [chemical binding]; other site 1114958005066 oxyanion hole (OAH) forming residues; other site 1114958005067 trimer interface [polypeptide binding]; other site 1114958005068 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114958005069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958005070 substrate binding site [chemical binding]; other site 1114958005071 oxyanion hole (OAH) forming residues; other site 1114958005072 trimer interface [polypeptide binding]; other site 1114958005073 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114958005074 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005075 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005076 Condensation domain; Region: Condensation; pfam00668 1114958005077 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005078 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005079 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005080 acyl-CoA synthetase; Validated; Region: PRK08308 1114958005081 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005082 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005083 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005084 active site 1114958005085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005086 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005087 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005088 putative NADP binding site [chemical binding]; other site 1114958005089 active site 1114958005090 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005091 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005092 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005093 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005094 active site 1114958005095 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005096 putative NADP binding site [chemical binding]; other site 1114958005097 active site 1114958005098 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005099 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005100 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005101 active site 1114958005102 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005103 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005104 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005105 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005106 active site 1114958005107 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005108 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005109 putative NADP binding site [chemical binding]; other site 1114958005110 active site 1114958005111 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005112 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005113 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005114 active site 1114958005115 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005116 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005117 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005118 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005119 active site 1114958005120 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005121 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005122 putative NADP binding site [chemical binding]; other site 1114958005123 active site 1114958005124 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005125 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005126 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005127 active site 1114958005128 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005129 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005130 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005131 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005132 active site 1114958005133 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005134 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005135 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005136 putative NADP binding site [chemical binding]; other site 1114958005137 active site 1114958005138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958005139 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005140 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005141 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005142 active site 1114958005143 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005144 putative NADP binding site [chemical binding]; other site 1114958005145 active site 1114958005146 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005147 Condensation domain; Region: Condensation; pfam00668 1114958005148 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005149 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005150 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005151 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005152 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005153 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005154 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005155 active site 1114958005156 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005157 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005158 putative NADP binding site [chemical binding]; other site 1114958005159 active site 1114958005160 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005161 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005162 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005163 active site 1114958005164 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005165 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005166 putative NADP binding site [chemical binding]; other site 1114958005167 active site 1114958005168 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005169 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005170 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005171 active site 1114958005172 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005173 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005174 putative NADP binding site [chemical binding]; other site 1114958005175 active site 1114958005176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958005177 S-adenosylmethionine binding site [chemical binding]; other site 1114958005178 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005179 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005180 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005181 active site 1114958005182 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005183 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1114958005184 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005185 active site 1114958005186 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005187 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005188 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1114958005189 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114958005190 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1114958005191 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 1114958005192 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1114958005193 active site 1114958005194 catalytic triad [active] 1114958005195 Protein of unknown function (DUF867); Region: DUF867; cl01713 1114958005196 OsmC-like protein; Region: OsmC; cl00767 1114958005197 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114958005198 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114958005199 YmaF family; Region: YmaF; pfam12788 1114958005200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958005201 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1114958005202 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 1114958005203 Sm1 motif; other site 1114958005204 intra - hexamer interaction site; other site 1114958005205 inter - hexamer interaction site [polypeptide binding]; other site 1114958005206 nucleotide binding pocket [chemical binding]; other site 1114958005207 Sm2 motif; other site 1114958005208 YmzC-like protein; Region: YmzC; pfam14157 1114958005209 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958005210 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1114958005211 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1114958005212 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1114958005213 active site 1114958005214 dimer interface [polypeptide binding]; other site 1114958005215 catalytic residues [active] 1114958005216 effector binding site; other site 1114958005217 R2 peptide binding site; other site 1114958005218 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1114958005219 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1114958005220 dimer interface [polypeptide binding]; other site 1114958005221 putative radical transfer pathway; other site 1114958005222 diiron center [ion binding]; other site 1114958005223 tyrosyl radical; other site 1114958005224 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1114958005225 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958005226 active site 1114958005227 metal binding site [ion binding]; metal-binding site 1114958005228 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1114958005229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958005230 Walker A motif; other site 1114958005231 ATP binding site [chemical binding]; other site 1114958005232 Walker B motif; other site 1114958005233 arginine finger; other site 1114958005234 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1114958005235 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1114958005236 HflX GTPase family; Region: HflX; cd01878 1114958005237 G1 box; other site 1114958005238 GTP/Mg2+ binding site [chemical binding]; other site 1114958005239 Switch I region; other site 1114958005240 G2 box; other site 1114958005241 G3 box; other site 1114958005242 Switch II region; other site 1114958005243 G4 box; other site 1114958005244 G5 box; other site 1114958005245 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1114958005246 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958005247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958005248 catalytic residue [active] 1114958005249 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1114958005250 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114958005251 DNA binding residues [nucleotide binding] 1114958005252 glutamine synthetase, type I; Region: GlnA; TIGR00653 1114958005253 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1114958005254 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114958005255 Major royal jelly protein; Region: MRJP; pfam03022 1114958005256 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1114958005257 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1114958005258 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1114958005259 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1114958005260 inhibitor binding site; inhibition site 1114958005261 active site 1114958005262 Helix-turn-helix domains; Region: HTH; cl00088 1114958005263 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114958005264 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1114958005265 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1114958005266 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1114958005267 N- and C-terminal domain interface [polypeptide binding]; other site 1114958005268 D-xylulose kinase; Region: XylB; TIGR01312 1114958005269 active site 1114958005270 catalytic site [active] 1114958005271 metal binding site [ion binding]; metal-binding site 1114958005272 xylulose binding site [chemical binding]; other site 1114958005273 putative ATP binding site [chemical binding]; other site 1114958005274 homodimer interface [polypeptide binding]; other site 1114958005275 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1114958005276 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114958005277 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114958005278 Predicted transcriptional regulator [Transcription]; Region: COG2378 1114958005279 Helix-turn-helix domains; Region: HTH; cl00088 1114958005280 WYL domain; Region: WYL; cl14852 1114958005281 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114958005282 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1114958005283 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1114958005284 NAD binding site [chemical binding]; other site 1114958005285 substrate binding site [chemical binding]; other site 1114958005286 catalytic Zn binding site [ion binding]; other site 1114958005287 tetramer interface [polypeptide binding]; other site 1114958005288 structural Zn binding site [ion binding]; other site 1114958005289 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958005290 YoaP-like; Region: YoaP; pfam14268 1114958005291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114958005292 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958005293 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1114958005294 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1114958005295 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958005296 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958005297 Chitin binding domain; Region: Chitin_bind_3; cl03871 1114958005298 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114958005299 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1114958005300 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1114958005301 trimer interface [polypeptide binding]; other site 1114958005302 active site 1114958005303 Protein of unknown function (DUF867); Region: DUF867; cl01713 1114958005304 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1114958005305 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1114958005306 LexA repressor; Validated; Region: PRK00215 1114958005307 Helix-turn-helix domains; Region: HTH; cl00088 1114958005308 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114958005309 Catalytic site [active] 1114958005310 cell division suppressor protein YneA; Provisional; Region: PRK14125 1114958005311 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 1114958005312 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1114958005313 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1114958005314 catalytic residues [active] 1114958005315 catalytic nucleophile [active] 1114958005316 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1114958005317 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 1114958005318 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1114958005319 TPP-binding site [chemical binding]; other site 1114958005320 dimer interface [polypeptide binding]; other site 1114958005321 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114958005322 PYR/PP interface [polypeptide binding]; other site 1114958005323 dimer interface [polypeptide binding]; other site 1114958005324 TPP binding site [chemical binding]; other site 1114958005325 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958005326 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1114958005327 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 1114958005328 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1114958005329 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1114958005330 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958005331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958005332 active site 1114958005333 phosphorylation site [posttranslational modification] 1114958005334 intermolecular recognition site; other site 1114958005335 dimerization interface [polypeptide binding]; other site 1114958005336 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1114958005337 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1114958005338 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1114958005339 Small acid-soluble spore protein P family; Region: SspP; cl12105 1114958005340 Small acid-soluble spore protein O family; Region: SspO; cl07943 1114958005341 aconitate hydratase; Validated; Region: PRK09277 1114958005342 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1114958005343 substrate binding site [chemical binding]; other site 1114958005344 ligand binding site [chemical binding]; other site 1114958005345 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1114958005346 substrate binding site [chemical binding]; other site 1114958005347 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1114958005348 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114958005349 catalytic residues [active] 1114958005350 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1114958005351 Small acid-soluble spore protein N family; Region: SspN; cl11659 1114958005352 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 1114958005353 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114958005354 active site 1114958005355 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1114958005356 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1114958005357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005358 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1114958005359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958005360 ATP binding site [chemical binding]; other site 1114958005361 Mg2+ binding site [ion binding]; other site 1114958005362 G-X-G motif; other site 1114958005363 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114958005364 anchoring element; other site 1114958005365 dimer interface [polypeptide binding]; other site 1114958005366 ATP binding site [chemical binding]; other site 1114958005367 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1114958005368 active site 1114958005369 metal binding site [ion binding]; metal-binding site 1114958005370 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114958005371 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1114958005372 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1114958005373 CAP-like domain; other site 1114958005374 active site 1114958005375 primary dimer interface [polypeptide binding]; other site 1114958005376 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958005377 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958005378 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958005379 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958005380 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1114958005381 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1114958005382 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958005383 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114958005384 substrate binding site [chemical binding]; other site 1114958005385 ATP binding site [chemical binding]; other site 1114958005386 putative oxidoreductase; Provisional; Region: PRK10083 1114958005387 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1114958005388 putative NAD(P) binding site [chemical binding]; other site 1114958005389 catalytic Zn binding site [ion binding]; other site 1114958005390 structural Zn binding site [ion binding]; other site 1114958005391 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1114958005392 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114958005393 active site 1114958005394 intersubunit interface [polypeptide binding]; other site 1114958005395 catalytic residue [active] 1114958005396 mannonate dehydratase; Provisional; Region: PRK03906 1114958005397 mannonate dehydratase; Region: uxuA; TIGR00695 1114958005398 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1114958005399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114958005400 putative NAD(P) binding site [chemical binding]; other site 1114958005401 active site 1114958005402 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958005403 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958005404 DNA binding site [nucleotide binding] 1114958005405 domain linker motif; other site 1114958005406 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1114958005407 putative dimerization interface [polypeptide binding]; other site 1114958005408 putative ligand binding site [chemical binding]; other site 1114958005409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958005410 D-galactonate transporter; Region: 2A0114; TIGR00893 1114958005411 putative substrate translocation pore; other site 1114958005412 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1114958005413 YndJ-like protein; Region: YndJ; pfam14158 1114958005414 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1114958005415 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 1114958005416 Cellulose binding domain; Region: CBM_3; cl03026 1114958005417 Tic20-like protein; Region: Tic20; pfam09685 1114958005418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114958005419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958005420 dimer interface [polypeptide binding]; other site 1114958005421 phosphorylation site [posttranslational modification] 1114958005422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958005423 ATP binding site [chemical binding]; other site 1114958005424 Mg2+ binding site [ion binding]; other site 1114958005425 G-X-G motif; other site 1114958005426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958005427 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958005428 active site 1114958005429 phosphorylation site [posttranslational modification] 1114958005430 intermolecular recognition site; other site 1114958005431 dimerization interface [polypeptide binding]; other site 1114958005432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958005433 DNA binding site [nucleotide binding] 1114958005434 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1114958005435 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1114958005436 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1114958005437 substrate binding site [chemical binding]; other site 1114958005438 active site 1114958005439 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1114958005440 metal binding site [ion binding]; metal-binding site 1114958005441 ligand binding site [chemical binding]; other site 1114958005442 peptide synthase; Provisional; Region: PRK12467 1114958005443 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005444 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005445 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005446 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005447 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005448 Thioesterase domain; Region: Thioesterase; pfam00975 1114958005449 peptide synthase; Provisional; Region: PRK12467 1114958005450 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005451 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005453 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005454 peptide synthase; Provisional; Region: PRK12316 1114958005455 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005456 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005457 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005458 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005459 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005460 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005461 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005462 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005463 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005464 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005465 peptide synthase; Provisional; Region: PRK12467 1114958005466 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005467 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005468 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005469 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005470 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114958005471 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005472 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005473 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005474 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005475 active site 1114958005476 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005477 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005478 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1114958005479 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958005480 inhibitor-cofactor binding pocket; inhibition site 1114958005481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005482 catalytic residue [active] 1114958005483 Condensation domain; Region: Condensation; pfam00668 1114958005484 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005485 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005486 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005487 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114958005488 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958005489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005490 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1114958005491 NAD(P) binding site [chemical binding]; other site 1114958005492 active site 1114958005493 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114958005494 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114958005495 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1114958005496 Citrate transporter; Region: CitMHS; pfam03600 1114958005497 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1114958005498 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114958005499 biotin synthase; Validated; Region: PRK06256 1114958005500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958005501 FeS/SAM binding site; other site 1114958005502 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1114958005503 AAA domain; Region: AAA_26; pfam13500 1114958005504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958005505 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1114958005506 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1114958005507 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1114958005508 substrate-cofactor binding pocket; other site 1114958005509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005510 catalytic residue [active] 1114958005511 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 1114958005512 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1114958005513 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1114958005514 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958005515 inhibitor-cofactor binding pocket; inhibition site 1114958005516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005517 catalytic residue [active] 1114958005518 GtrA-like protein; Region: GtrA; cl00971 1114958005519 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1114958005520 active site 1114958005521 tetramer interface; other site 1114958005522 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114958005523 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114958005524 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1114958005525 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114958005526 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114958005527 enoyl-CoA hydratase; Provisional; Region: PRK07657 1114958005528 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958005529 substrate binding site [chemical binding]; other site 1114958005530 oxyanion hole (OAH) forming residues; other site 1114958005531 trimer interface [polypeptide binding]; other site 1114958005532 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1114958005533 active site 1114958005534 catalytic residues [active] 1114958005535 metal binding site [ion binding]; metal-binding site 1114958005536 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114958005537 carboxyltransferase (CT) interaction site; other site 1114958005538 biotinylation site [posttranslational modification]; other site 1114958005539 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1114958005540 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958005541 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958005542 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114958005543 AMP-binding domain protein; Validated; Region: PRK08315 1114958005544 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005545 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958005546 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114958005547 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1114958005548 FAD binding site [chemical binding]; other site 1114958005549 homotetramer interface [polypeptide binding]; other site 1114958005550 substrate binding pocket [chemical binding]; other site 1114958005551 catalytic base [active] 1114958005552 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 1114958005553 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1114958005554 peptide synthase; Provisional; Region: PRK12467 1114958005555 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005556 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005557 peptide synthase; Provisional; Region: PRK12467 1114958005558 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005559 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005560 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005561 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005562 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005563 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005564 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005565 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005566 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005567 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005568 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005569 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005570 Condensation domain; Region: Condensation; pfam00668 1114958005571 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005572 peptide synthase; Validated; Region: PRK05691 1114958005573 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005574 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005575 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005576 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005577 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005578 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005579 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005580 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005581 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005582 acyl-CoA synthetase; Validated; Region: PRK08308 1114958005583 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005584 peptide synthase; Provisional; Region: PRK12316 1114958005585 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005586 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005587 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005588 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005589 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005590 peptide synthase; Provisional; Region: PRK12467 1114958005591 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005592 peptide synthase; Provisional; Region: PRK12316 1114958005593 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005594 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005595 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005596 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005597 peptide synthase; Provisional; Region: PRK12467 1114958005598 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005599 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005600 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958005601 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958005602 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958005604 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1114958005605 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1114958005606 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1114958005607 active site 1114958005608 catalytic residues [active] 1114958005609 MatE; Region: MatE; cl10513 1114958005610 MatE; Region: MatE; cl10513 1114958005611 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958005612 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 1114958005613 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958005614 amidase catalytic site [active] 1114958005615 substrate binding site [chemical binding]; other site 1114958005616 Zn binding residues [ion binding]; other site 1114958005617 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958005618 Phage lysis protein, holin; Region: Phage_holin; cl04675 1114958005619 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1114958005620 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1114958005621 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1114958005622 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114958005623 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1114958005624 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114958005625 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1114958005626 Phage tail protein; Region: Sipho_tail; pfam05709 1114958005627 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114958005628 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958005629 catalytic residue [active] 1114958005630 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1114958005631 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1114958005632 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1114958005633 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1114958005634 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1114958005635 oligomerization interface [polypeptide binding]; other site 1114958005636 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1114958005637 Phage capsid family; Region: Phage_capsid; pfam05065 1114958005638 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1114958005639 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1114958005640 Phage portal protein; Region: Phage_portal; pfam04860 1114958005641 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1114958005642 Phage Terminase; Region: Terminase_1; pfam03354 1114958005643 Phage terminase, small subunit; Region: Terminase_4; cl01525 1114958005644 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1114958005645 Int/Topo IB signature motif; other site 1114958005646 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1114958005647 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1114958005648 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1114958005649 hypothetical protein; Validated; Region: PRK08116 1114958005650 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958005651 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 1114958005652 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 1114958005653 Domain of unknown function (DUF771); Region: DUF771; cl09962 1114958005654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958005655 non-specific DNA binding site [nucleotide binding]; other site 1114958005656 salt bridge; other site 1114958005657 sequence-specific DNA binding site [nucleotide binding]; other site 1114958005658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958005659 sequence-specific DNA binding site [nucleotide binding]; other site 1114958005660 salt bridge; other site 1114958005661 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958005662 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1114958005663 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1114958005664 Int/Topo IB signature motif; other site 1114958005665 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1114958005666 Int/Topo IB signature motif; other site 1114958005667 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1114958005668 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1114958005669 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1114958005670 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958005671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958005672 putative substrate translocation pore; other site 1114958005673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958005674 dimerization interface [polypeptide binding]; other site 1114958005675 putative DNA binding site [nucleotide binding]; other site 1114958005676 putative Zn2+ binding site [ion binding]; other site 1114958005677 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1114958005678 anticodon binding site; other site 1114958005679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958005680 Helix-turn-helix domains; Region: HTH; cl00088 1114958005681 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1114958005682 putative dimerization interface [polypeptide binding]; other site 1114958005683 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958005684 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114958005685 NAD(P) binding site [chemical binding]; other site 1114958005686 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1114958005687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005688 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1114958005689 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1114958005690 active site 1114958005691 dimer interface [polypeptide binding]; other site 1114958005692 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1114958005693 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114958005694 active site 1114958005695 FMN binding site [chemical binding]; other site 1114958005696 substrate binding site [chemical binding]; other site 1114958005697 3Fe-4S cluster binding site [ion binding]; other site 1114958005698 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1114958005699 domain interface; other site 1114958005700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958005701 Helix-turn-helix domains; Region: HTH; cl00088 1114958005702 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1114958005703 putative dimerization interface [polypeptide binding]; other site 1114958005704 gamma-glutamyl kinase; Provisional; Region: PRK13402 1114958005705 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1114958005706 nucleotide binding site [chemical binding]; other site 1114958005707 homotetrameric interface [polypeptide binding]; other site 1114958005708 putative phosphate binding site [ion binding]; other site 1114958005709 putative allosteric binding site; other site 1114958005710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005711 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1114958005712 Replication terminator protein; Region: RTP; pfam02334 1114958005713 classical (c) SDRs; Region: SDR_c; cd05233 1114958005714 NAD(P) binding site [chemical binding]; other site 1114958005715 active site 1114958005716 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1114958005717 polyol permease family; Region: 2A0118; TIGR00897 1114958005718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958005719 putative substrate translocation pore; other site 1114958005720 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1114958005721 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1114958005722 N- and C-terminal domain interface [polypeptide binding]; other site 1114958005723 active site 1114958005724 MgATP binding site [chemical binding]; other site 1114958005725 catalytic site [active] 1114958005726 metal binding site [ion binding]; metal-binding site 1114958005727 carbohydrate binding site [chemical binding]; other site 1114958005728 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114958005729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005730 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1114958005731 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1114958005732 putative [4Fe-4S] binding site [ion binding]; other site 1114958005733 putative molybdopterin cofactor binding site [chemical binding]; other site 1114958005734 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1114958005735 putative molybdopterin cofactor binding site; other site 1114958005736 Helix-turn-helix domains; Region: HTH; cl00088 1114958005737 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958005738 classical (c) SDRs; Region: SDR_c; cd05233 1114958005739 NAD(P) binding site [chemical binding]; other site 1114958005740 active site 1114958005741 Helix-turn-helix domains; Region: HTH; cl00088 1114958005742 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1114958005743 dimer interface [polypeptide binding]; other site 1114958005744 putative tRNA-binding site [nucleotide binding]; other site 1114958005745 Cupin domain; Region: Cupin_2; cl09118 1114958005746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958005747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958005748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958005749 Helix-turn-helix domains; Region: HTH; cl00088 1114958005750 WHG domain; Region: WHG; pfam13305 1114958005751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958005752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958005753 dimerization interface [polypeptide binding]; other site 1114958005754 putative DNA binding site [nucleotide binding]; other site 1114958005755 putative Zn2+ binding site [ion binding]; other site 1114958005756 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114958005757 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958005758 catalytic residue [active] 1114958005759 Protein of unknown function (DUF420); Region: DUF420; cl00989 1114958005760 Protein required for attachment to host cells; Region: Host_attach; cl02398 1114958005761 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1114958005762 putative dimer interface [polypeptide binding]; other site 1114958005763 catalytic triad [active] 1114958005764 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958005765 putative peptidoglycan binding site; other site 1114958005766 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958005767 putative peptidoglycan binding site; other site 1114958005768 3D domain; Region: 3D; cl01439 1114958005769 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1114958005770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958005771 ATP binding site [chemical binding]; other site 1114958005772 putative Mg++ binding site [ion binding]; other site 1114958005773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958005774 nucleotide binding region [chemical binding]; other site 1114958005775 ATP-binding site [chemical binding]; other site 1114958005776 RQC domain; Region: RQC; cl09632 1114958005777 HRDC domain; Region: HRDC; cl02578 1114958005778 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958005779 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1114958005780 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1114958005781 putative dimer interface [polypeptide binding]; other site 1114958005782 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1114958005783 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114958005784 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114958005785 NAD(P) binding site [chemical binding]; other site 1114958005786 catalytic residues [active] 1114958005787 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1114958005788 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 1114958005789 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1114958005790 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1114958005791 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114958005792 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114958005793 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 1114958005794 bile acid transporter; Region: bass; TIGR00841 1114958005795 Membrane transport protein; Region: Mem_trans; cl09117 1114958005796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958005797 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1114958005798 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114958005799 E3 interaction surface; other site 1114958005800 lipoyl attachment site [posttranslational modification]; other site 1114958005801 e3 binding domain; Region: E3_binding; pfam02817 1114958005802 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1114958005803 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1114958005804 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1114958005805 TPP-binding site [chemical binding]; other site 1114958005806 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1114958005807 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1114958005808 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1114958005809 metal ion-dependent adhesion site (MIDAS); other site 1114958005810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958005811 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114958005812 Walker A motif; other site 1114958005813 ATP binding site [chemical binding]; other site 1114958005814 Walker B motif; other site 1114958005815 arginine finger; other site 1114958005816 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1114958005817 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1114958005818 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1114958005819 E-class dimer interface [polypeptide binding]; other site 1114958005820 P-class dimer interface [polypeptide binding]; other site 1114958005821 active site 1114958005822 Cu2+ binding site [ion binding]; other site 1114958005823 Zn2+ binding site [ion binding]; other site 1114958005824 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958005825 putative peptidoglycan binding site; other site 1114958005826 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958005827 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958005828 putative peptidoglycan binding site; other site 1114958005829 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958005830 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958005831 putative peptidoglycan binding site; other site 1114958005832 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958005833 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958005834 putative peptidoglycan binding site; other site 1114958005835 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958005836 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1114958005837 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1114958005838 active site 1114958005839 TDP-binding site; other site 1114958005840 acceptor substrate-binding pocket; other site 1114958005841 homodimer interface [polypeptide binding]; other site 1114958005842 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1114958005843 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1114958005844 multidrug efflux protein; Reviewed; Region: PRK01766 1114958005845 MatE; Region: MatE; cl10513 1114958005846 MatE; Region: MatE; cl10513 1114958005847 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958005848 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1114958005849 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1114958005850 rarD protein; Region: rarD; TIGR00688 1114958005851 EamA-like transporter family; Region: EamA; cl01037 1114958005852 EamA-like transporter family; Region: EamA; cl01037 1114958005853 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114958005854 Helix-turn-helix domains; Region: HTH; cl00088 1114958005855 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1114958005856 dimer interface [polypeptide binding]; other site 1114958005857 FMN binding site [chemical binding]; other site 1114958005858 Predicted esterase [General function prediction only]; Region: COG0400 1114958005859 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1114958005860 Zn binding site [ion binding]; other site 1114958005861 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1114958005862 Zn binding site [ion binding]; other site 1114958005863 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1114958005864 Sodium:solute symporter family; Region: SSF; cl00456 1114958005865 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1114958005866 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1114958005867 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1114958005868 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114958005869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958005870 DNA-binding site [nucleotide binding]; DNA binding site 1114958005871 UTRA domain; Region: UTRA; cl01230 1114958005872 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114958005873 C-terminal peptidase (prc); Region: prc; TIGR00225 1114958005874 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114958005875 protein binding site [polypeptide binding]; other site 1114958005876 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1114958005877 Catalytic dyad [active] 1114958005878 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958005879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958005880 S-adenosylmethionine binding site [chemical binding]; other site 1114958005881 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1114958005882 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1114958005883 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1114958005884 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1114958005885 YodL-like; Region: YodL; pfam14191 1114958005886 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1114958005887 active site 1114958005888 YozD-like protein; Region: YozD; pfam14162 1114958005889 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114958005890 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 1114958005891 YokU-like protein; Region: YokU; cl15819 1114958005892 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1114958005893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958005894 FeS/SAM binding site; other site 1114958005895 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1114958005896 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1114958005897 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958005898 acetylornithine deacetylase; Validated; Region: PRK06915 1114958005899 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1114958005900 metal binding site [ion binding]; metal-binding site 1114958005901 dimer interface [polypeptide binding]; other site 1114958005902 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114958005903 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114958005904 hypothetical protein; Provisional; Region: PRK06917 1114958005905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958005906 inhibitor-cofactor binding pocket; inhibition site 1114958005907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005908 catalytic residue [active] 1114958005909 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1114958005910 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114958005911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958005912 Coenzyme A binding pocket [chemical binding]; other site 1114958005913 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958005914 active site 1114958005915 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1114958005916 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114958005917 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 1114958005918 Phytase; Region: Phytase; pfam02333 1114958005919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005920 NAD(P) binding site [chemical binding]; other site 1114958005921 active site 1114958005922 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1114958005923 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1114958005924 YoqO-like protein; Region: YoqO; pfam14037 1114958005925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958005926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958005927 binding surface 1114958005928 TPR motif; other site 1114958005929 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958005930 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 1114958005931 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958005932 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1114958005933 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1114958005934 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958005935 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1114958005936 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1114958005937 Staphylococcal nuclease homologues; Region: SNc; smart00318 1114958005938 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1114958005939 Catalytic site; other site 1114958005940 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1114958005941 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1114958005942 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1114958005943 catalytic residues [active] 1114958005944 catalytic nucleophile [active] 1114958005945 Recombinase; Region: Recombinase; pfam07508 1114958005946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005947 active site 1114958005948 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1114958005949 SelR domain; Region: SelR; pfam01641 1114958005950 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1114958005951 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958005952 Helix-turn-helix domains; Region: HTH; cl00088 1114958005953 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1114958005954 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1114958005955 active site 1114958005956 catalytic triad [active] 1114958005957 oxyanion hole [active] 1114958005958 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1114958005959 Cu(I) binding site [ion binding]; other site 1114958005960 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1114958005961 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114958005962 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1114958005963 putative Ile/Val binding site [chemical binding]; other site 1114958005964 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114958005965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005966 catalytic residue [active] 1114958005967 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1114958005968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958005969 Walker A motif; other site 1114958005970 ATP binding site [chemical binding]; other site 1114958005971 Walker B motif; other site 1114958005972 arginine finger; other site 1114958005973 Haemolysin-III related; Region: HlyIII; cl03831 1114958005974 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958005975 putative acyl-acceptor binding pocket; other site 1114958005976 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1114958005977 folate binding site [chemical binding]; other site 1114958005978 NADP+ binding site [chemical binding]; other site 1114958005979 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1114958005980 dimerization interface [polypeptide binding]; other site 1114958005981 active site 1114958005982 YpjP-like protein; Region: YpjP; pfam14005 1114958005983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958005984 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1114958005985 Dehydratase family; Region: ILVD_EDD; cl00340 1114958005986 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1114958005987 Virulence factor; Region: Virulence_fact; pfam13769 1114958005988 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1114958005989 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 1114958005990 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1114958005991 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114958005992 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114958005993 catalytic residues [active] 1114958005994 dimer interface [polypeptide binding]; other site 1114958005995 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1114958005996 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1114958005997 proposed active site lysine [active] 1114958005998 conserved cys residue [active] 1114958005999 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1114958006000 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114958006001 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1114958006002 DNA-binding site [nucleotide binding]; DNA binding site 1114958006003 RNA-binding motif; other site 1114958006004 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1114958006005 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1114958006006 hypothetical protein; Validated; Region: PRK07708 1114958006007 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1114958006008 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114958006009 active site 1114958006010 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1114958006011 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1114958006012 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114958006013 active site 1114958006014 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1114958006015 5'-3' exonuclease; Region: 53EXOc; smart00475 1114958006016 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1114958006017 active site 1114958006018 metal binding site 1 [ion binding]; metal-binding site 1114958006019 putative 5' ssDNA interaction site; other site 1114958006020 metal binding site 3; metal-binding site 1114958006021 metal binding site 2 [ion binding]; metal-binding site 1114958006022 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1114958006023 putative DNA binding site [nucleotide binding]; other site 1114958006024 putative metal binding site [ion binding]; other site 1114958006025 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1114958006026 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1114958006027 Dynamin family; Region: Dynamin_N; pfam00350 1114958006028 G1 box; other site 1114958006029 GTP/Mg2+ binding site [chemical binding]; other site 1114958006030 G2 box; other site 1114958006031 Switch I region; other site 1114958006032 G3 box; other site 1114958006033 Switch II region; other site 1114958006034 G4 box; other site 1114958006035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958006036 G1 box; other site 1114958006037 GTP/Mg2+ binding site [chemical binding]; other site 1114958006038 Dynamin family; Region: Dynamin_N; pfam00350 1114958006039 G2 box; other site 1114958006040 Switch I region; other site 1114958006041 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1114958006042 G3 box; other site 1114958006043 Switch II region; other site 1114958006044 GTP/Mg2+ binding site [chemical binding]; other site 1114958006045 G4 box; other site 1114958006046 G5 box; other site 1114958006047 Phospholipid methyltransferase; Region: PEMT; cl00763 1114958006048 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1114958006049 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1114958006050 malonyl-CoA binding site [chemical binding]; other site 1114958006051 dimer interface [polypeptide binding]; other site 1114958006052 active site 1114958006053 product binding site; other site 1114958006054 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114958006055 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114958006056 DNA binding site [nucleotide binding] 1114958006057 active site 1114958006058 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114958006059 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114958006060 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958006061 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114958006062 catalytic triad [active] 1114958006063 conserved cis-peptide bond; other site 1114958006064 xanthine permease; Region: pbuX; TIGR03173 1114958006065 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 1114958006066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958006067 active site 1114958006068 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1114958006069 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1114958006070 active site 1114958006071 Zn binding site [ion binding]; other site 1114958006072 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1114958006073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958006074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958006075 YpzG-like protein; Region: YpzG; pfam14139 1114958006076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958006077 THUMP domain; Region: THUMP; cl12076 1114958006078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958006079 cell division protein GpsB; Provisional; Region: PRK14127 1114958006080 DivIVA domain; Region: DivI1A_domain; TIGR03544 1114958006081 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 1114958006082 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1114958006083 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1114958006084 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1114958006085 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1114958006086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958006087 ATP binding site [chemical binding]; other site 1114958006088 putative Mg++ binding site [ion binding]; other site 1114958006089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958006090 nucleotide binding region [chemical binding]; other site 1114958006091 ATP-binding site [chemical binding]; other site 1114958006092 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1114958006093 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1114958006094 HPr interaction site; other site 1114958006095 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114958006096 active site 1114958006097 phosphorylation site [posttranslational modification] 1114958006098 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114958006099 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1114958006100 YppG-like protein; Region: YppG; pfam14179 1114958006101 YppF-like protein; Region: YppF; pfam14178 1114958006102 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1114958006103 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1114958006104 Recombination protein U; Region: RecU; cl01314 1114958006105 Transglycosylase; Region: Transgly; cl07896 1114958006106 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1114958006107 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958006108 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1114958006109 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1114958006110 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114958006111 minor groove reading motif; other site 1114958006112 helix-hairpin-helix signature motif; other site 1114958006113 substrate binding pocket [chemical binding]; other site 1114958006114 active site 1114958006115 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1114958006116 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1114958006117 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1114958006118 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1114958006119 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1114958006120 putative dimer interface [polypeptide binding]; other site 1114958006121 putative anticodon binding site; other site 1114958006122 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1114958006123 homodimer interface [polypeptide binding]; other site 1114958006124 motif 1; other site 1114958006125 motif 2; other site 1114958006126 active site 1114958006127 motif 3; other site 1114958006128 aspartate aminotransferase; Provisional; Region: PRK05764 1114958006129 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958006130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006131 homodimer interface [polypeptide binding]; other site 1114958006132 catalytic residue [active] 1114958006133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1114958006134 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1114958006135 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1114958006136 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1114958006137 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114958006138 active site 1114958006139 catalytic site [active] 1114958006140 substrate binding site [chemical binding]; other site 1114958006141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958006142 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1114958006143 tetramerization interface [polypeptide binding]; other site 1114958006144 active site 1114958006145 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1114958006146 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1114958006147 active site 1114958006148 ATP-binding site [chemical binding]; other site 1114958006149 pantoate-binding site; other site 1114958006150 HXXH motif; other site 1114958006151 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1114958006152 oligomerization interface [polypeptide binding]; other site 1114958006153 active site 1114958006154 metal binding site [ion binding]; metal-binding site 1114958006155 Helix-turn-helix domains; Region: HTH; cl00088 1114958006156 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1114958006157 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1114958006158 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1114958006159 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1114958006160 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1114958006161 active site 1114958006162 NTP binding site [chemical binding]; other site 1114958006163 metal binding triad [ion binding]; metal-binding site 1114958006164 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1114958006165 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114958006166 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1114958006167 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1114958006168 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1114958006169 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1114958006170 active site 1114958006171 dimer interfaces [polypeptide binding]; other site 1114958006172 catalytic residues [active] 1114958006173 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1114958006174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006175 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1114958006176 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1114958006177 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958006178 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958006179 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958006180 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1114958006181 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1114958006182 Cupin domain; Region: Cupin_2; cl09118 1114958006183 Cupin domain; Region: Cupin_2; cl09118 1114958006184 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 1114958006185 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1114958006186 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1114958006187 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1114958006188 Cytochrome c; Region: Cytochrom_C; cl11414 1114958006189 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1114958006190 interchain domain interface [polypeptide binding]; other site 1114958006191 intrachain domain interface; other site 1114958006192 heme bH binding site [chemical binding]; other site 1114958006193 Qi binding site; other site 1114958006194 heme bL binding site [chemical binding]; other site 1114958006195 Qo binding site; other site 1114958006196 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1114958006197 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1114958006198 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114958006199 iron-sulfur cluster [ion binding]; other site 1114958006200 [2Fe-2S] cluster binding site [ion binding]; other site 1114958006201 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1114958006202 hypothetical protein; Provisional; Region: PRK03636 1114958006203 UPF0302 domain; Region: UPF0302; pfam08864 1114958006204 IDEAL domain; Region: IDEAL; cl07452 1114958006205 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958006206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958006207 TPR motif; other site 1114958006208 binding surface 1114958006209 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1114958006210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958006211 binding surface 1114958006212 TPR motif; other site 1114958006213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958006214 binding surface 1114958006215 TPR motif; other site 1114958006216 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1114958006217 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1114958006218 hinge; other site 1114958006219 active site 1114958006220 prephenate dehydrogenase; Validated; Region: PRK06545 1114958006221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006222 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1114958006223 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1114958006224 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958006225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006226 homodimer interface [polypeptide binding]; other site 1114958006227 catalytic residue [active] 1114958006228 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1114958006229 substrate binding site [chemical binding]; other site 1114958006230 active site 1114958006231 catalytic residues [active] 1114958006232 heterodimer interface [polypeptide binding]; other site 1114958006233 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1114958006234 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1114958006235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006236 catalytic residue [active] 1114958006237 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 1114958006238 active site 1114958006239 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1114958006240 active site 1114958006241 ribulose/triose binding site [chemical binding]; other site 1114958006242 phosphate binding site [ion binding]; other site 1114958006243 substrate (anthranilate) binding pocket [chemical binding]; other site 1114958006244 product (indole) binding pocket [chemical binding]; other site 1114958006245 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1114958006246 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114958006247 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114958006248 anthranilate synthase component I; Provisional; Region: PRK13569 1114958006249 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114958006250 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114958006251 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1114958006252 homotrimer interaction site [polypeptide binding]; other site 1114958006253 active site 1114958006254 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1114958006255 active site 1114958006256 dimer interface [polypeptide binding]; other site 1114958006257 metal binding site [ion binding]; metal-binding site 1114958006258 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1114958006259 Tetramer interface [polypeptide binding]; other site 1114958006260 active site 1114958006261 FMN-binding site [chemical binding]; other site 1114958006262 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1114958006263 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114958006264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958006265 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1114958006266 active site 1114958006267 multimer interface [polypeptide binding]; other site 1114958006268 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114958006269 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114958006270 substrate binding pocket [chemical binding]; other site 1114958006271 chain length determination region; other site 1114958006272 substrate-Mg2+ binding site; other site 1114958006273 catalytic residues [active] 1114958006274 aspartate-rich region 1; other site 1114958006275 active site lid residues [active] 1114958006276 aspartate-rich region 2; other site 1114958006277 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1114958006278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958006279 S-adenosylmethionine binding site [chemical binding]; other site 1114958006280 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1114958006281 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 1114958006282 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114958006283 homodecamer interface [polypeptide binding]; other site 1114958006284 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114958006285 active site 1114958006286 putative catalytic site residues [active] 1114958006287 zinc binding site [ion binding]; other site 1114958006288 GTP-CH-I/GFRP interaction surface; other site 1114958006289 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114958006290 IHF dimer interface [polypeptide binding]; other site 1114958006291 IHF - DNA interface [nucleotide binding]; other site 1114958006292 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 1114958006293 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1114958006294 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1114958006295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006296 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1114958006297 GTP-binding protein Der; Reviewed; Region: PRK00093 1114958006298 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1114958006299 G1 box; other site 1114958006300 GTP/Mg2+ binding site [chemical binding]; other site 1114958006301 Switch I region; other site 1114958006302 G2 box; other site 1114958006303 Switch II region; other site 1114958006304 G3 box; other site 1114958006305 G4 box; other site 1114958006306 G5 box; other site 1114958006307 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1114958006308 G1 box; other site 1114958006309 GTP/Mg2+ binding site [chemical binding]; other site 1114958006310 Switch I region; other site 1114958006311 G2 box; other site 1114958006312 G3 box; other site 1114958006313 Switch II region; other site 1114958006314 G4 box; other site 1114958006315 G5 box; other site 1114958006316 YpzI-like protein; Region: YpzI; pfam14140 1114958006317 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1114958006318 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1114958006319 homotetramer interface [polypeptide binding]; other site 1114958006320 FMN binding site [chemical binding]; other site 1114958006321 homodimer contacts [polypeptide binding]; other site 1114958006322 putative active site [active] 1114958006323 putative substrate binding site [chemical binding]; other site 1114958006324 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1114958006325 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114958006326 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1114958006327 RNA binding site [nucleotide binding]; other site 1114958006328 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 1114958006329 RNA binding site [nucleotide binding]; other site 1114958006330 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1114958006331 RNA binding site [nucleotide binding]; other site 1114958006332 cytidylate kinase; Provisional; Region: cmk; PRK00023 1114958006333 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1114958006334 CMP-binding site; other site 1114958006335 The sites determining sugar specificity; other site 1114958006336 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1114958006337 PilZ domain; Region: PilZ; cl01260 1114958006338 germination protein YpeB; Region: spore_YpeB; TIGR02889 1114958006339 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1114958006340 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958006341 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1114958006342 Protease prsW family; Region: PrsW-protease; cl15823 1114958006343 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1114958006344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006345 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1114958006346 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114958006347 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1114958006348 NAD(P) binding site [chemical binding]; other site 1114958006349 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1114958006350 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1114958006351 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958006352 putative active site [active] 1114958006353 putative metal binding site [ion binding]; other site 1114958006354 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1114958006355 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 1114958006356 CAAX protease self-immunity; Region: Abi; cl00558 1114958006357 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1114958006358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958006359 ATP binding site [chemical binding]; other site 1114958006360 putative Mg++ binding site [ion binding]; other site 1114958006361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958006362 nucleotide binding region [chemical binding]; other site 1114958006363 ATP-binding site [chemical binding]; other site 1114958006364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1114958006365 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1114958006366 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1114958006367 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1114958006368 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1114958006369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006370 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1114958006371 putative L-serine binding site [chemical binding]; other site 1114958006372 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1114958006373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958006374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958006375 DNA binding residues [nucleotide binding] 1114958006376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1114958006377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958006378 dimerization interface [polypeptide binding]; other site 1114958006379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958006380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958006381 dimer interface [polypeptide binding]; other site 1114958006382 phosphorylation site [posttranslational modification] 1114958006383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958006384 ATP binding site [chemical binding]; other site 1114958006385 Mg2+ binding site [ion binding]; other site 1114958006386 G-X-G motif; other site 1114958006387 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958006389 active site 1114958006390 phosphorylation site [posttranslational modification] 1114958006391 intermolecular recognition site; other site 1114958006392 dimerization interface [polypeptide binding]; other site 1114958006393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958006394 DNA binding site [nucleotide binding] 1114958006395 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1114958006396 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1114958006397 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1114958006398 ResB-like family; Region: ResB; pfam05140 1114958006399 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114958006400 catalytic residues [active] 1114958006401 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114958006402 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958006403 RNA binding surface [nucleotide binding]; other site 1114958006404 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1114958006405 active site 1114958006406 Nucleoside recognition; Region: Gate; cl00486 1114958006407 Nucleoside recognition; Region: Gate; cl00486 1114958006408 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1114958006409 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958006410 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1114958006411 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1114958006412 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1114958006413 ScpA/B protein; Region: ScpA_ScpB; cl00598 1114958006414 Domain of unknown function (DUF309); Region: DUF309; cl00667 1114958006415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958006416 Coenzyme A binding pocket [chemical binding]; other site 1114958006417 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1114958006418 homopentamer interface [polypeptide binding]; other site 1114958006419 active site 1114958006420 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1114958006421 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1114958006422 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1114958006423 dimerization interface [polypeptide binding]; other site 1114958006424 active site 1114958006425 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1114958006426 Lumazine binding domain; Region: Lum_binding; pfam00677 1114958006427 Lumazine binding domain; Region: Lum_binding; pfam00677 1114958006428 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1114958006429 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1114958006430 catalytic motif [active] 1114958006431 Zn binding site [ion binding]; other site 1114958006432 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1114958006433 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1114958006434 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114958006435 Catalytic site [active] 1114958006436 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1114958006437 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1114958006438 active site 1114958006439 Predicted secreted protein [Function unknown]; Region: COG4086 1114958006440 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1114958006441 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1114958006442 active site 1114958006443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114958006444 substrate binding site [chemical binding]; other site 1114958006445 catalytic residues [active] 1114958006446 dimer interface [polypeptide binding]; other site 1114958006447 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958006448 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1114958006449 SpoVA protein; Region: SpoVA; cl04298 1114958006450 stage V sporulation protein AD; Validated; Region: PRK08304 1114958006451 stage V sporulation protein AD; Provisional; Region: PRK12404 1114958006452 SpoVA protein; Region: SpoVA; cl04298 1114958006453 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1114958006454 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1114958006455 sporulation sigma factor SigF; Validated; Region: PRK05572 1114958006456 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958006457 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958006458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958006459 DNA binding residues [nucleotide binding] 1114958006460 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1114958006461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958006462 ATP binding site [chemical binding]; other site 1114958006463 Mg2+ binding site [ion binding]; other site 1114958006464 G-X-G motif; other site 1114958006465 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1114958006466 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1114958006467 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958006468 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1114958006469 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1114958006470 Sulfatase; Region: Sulfatase; cl10460 1114958006471 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1114958006472 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1114958006473 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1114958006474 active site 1114958006475 Int/Topo IB signature motif; other site 1114958006476 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1114958006477 ferric uptake regulator; Provisional; Region: fur; PRK09462 1114958006478 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114958006479 metal binding site 2 [ion binding]; metal-binding site 1114958006480 putative DNA binding helix; other site 1114958006481 metal binding site 1 [ion binding]; metal-binding site 1114958006482 dimer interface [polypeptide binding]; other site 1114958006483 structural Zn2+ binding site [ion binding]; other site 1114958006484 Integral membrane protein DUF95; Region: DUF95; cl00572 1114958006485 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114958006486 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114958006487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006488 NAD(P) binding pocket [chemical binding]; other site 1114958006489 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1114958006490 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1114958006491 Aspartase; Region: Aspartase; cd01357 1114958006492 active sites [active] 1114958006493 tetramer interface [polypeptide binding]; other site 1114958006494 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1114958006495 active site 1114958006496 homodimer interface [polypeptide binding]; other site 1114958006497 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958006498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958006499 non-specific DNA binding site [nucleotide binding]; other site 1114958006500 salt bridge; other site 1114958006501 sequence-specific DNA binding site [nucleotide binding]; other site 1114958006502 TIGR00375 family protein; Region: TIGR00375 1114958006503 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1114958006504 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114958006505 dimer interface [polypeptide binding]; other site 1114958006506 ADP-ribose binding site [chemical binding]; other site 1114958006507 active site 1114958006508 nudix motif; other site 1114958006509 metal binding site [ion binding]; metal-binding site 1114958006510 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1114958006511 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114958006512 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958006513 active site 1114958006514 catalytic tetrad [active] 1114958006515 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114958006516 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958006517 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958006518 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1114958006519 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1114958006520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1114958006521 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958006522 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1114958006523 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1114958006524 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114958006525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958006526 Coenzyme A binding pocket [chemical binding]; other site 1114958006527 DNA polymerase IV; Reviewed; Region: PRK03103 1114958006528 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1114958006529 active site 1114958006530 DNA binding site [nucleotide binding] 1114958006531 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1114958006532 YolD-like protein; Region: YolD; pfam08863 1114958006533 YqzH-like protein; Region: YqzH; pfam14164 1114958006534 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958006535 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114958006536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958006537 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1114958006538 putative dimer interface [polypeptide binding]; other site 1114958006539 ligand binding site [chemical binding]; other site 1114958006540 Zn binding site [ion binding]; other site 1114958006541 pantothenate kinase; Provisional; Region: PRK05439 1114958006542 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 1114958006543 ATP-binding site [chemical binding]; other site 1114958006544 CoA-binding site [chemical binding]; other site 1114958006545 Mg2+-binding site [ion binding]; other site 1114958006546 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1114958006547 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1114958006548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958006549 catalytic residue [active] 1114958006550 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114958006551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006552 NAD(P) binding site [chemical binding]; other site 1114958006553 active site 1114958006554 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1114958006555 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958006556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006557 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1114958006558 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114958006559 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958006560 substrate binding site [chemical binding]; other site 1114958006561 oxyanion hole (OAH) forming residues; other site 1114958006562 trimer interface [polypeptide binding]; other site 1114958006563 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1114958006564 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 1114958006565 dimer interface [polypeptide binding]; other site 1114958006566 active site 1114958006567 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114958006568 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958006570 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006571 polyketide synthase; Region: polyketide_synthase; cd08251 1114958006572 Enoylreductase; Region: PKS_ER; smart00829 1114958006573 putative NAD(P) binding site [chemical binding]; other site 1114958006574 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006575 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006576 active site 1114958006577 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006578 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1114958006579 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006580 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1114958006581 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006582 active site 1114958006583 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006584 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006585 putative NADP binding site [chemical binding]; other site 1114958006586 active site 1114958006587 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006588 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006589 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006590 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006591 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006592 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006593 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006594 putative NADP binding site [chemical binding]; other site 1114958006595 active site 1114958006596 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006597 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006598 active site 1114958006599 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006600 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006601 putative NADP binding site [chemical binding]; other site 1114958006602 active site 1114958006603 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006604 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006605 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006606 active site 1114958006607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958006608 S-adenosylmethionine binding site [chemical binding]; other site 1114958006609 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006610 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006611 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006612 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006613 active site 1114958006614 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006615 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006616 putative NADP binding site [chemical binding]; other site 1114958006617 active site 1114958006618 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006619 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006620 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006621 active site 1114958006622 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006623 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006624 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006625 putative NADP binding site [chemical binding]; other site 1114958006626 active site 1114958006627 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006628 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006629 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006630 active site 1114958006631 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006632 putative NADP binding site [chemical binding]; other site 1114958006633 active site 1114958006634 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006635 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006636 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006637 active site 1114958006638 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006639 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006640 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006641 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006642 active site 1114958006643 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006644 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006645 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006646 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006647 putative NADP binding site [chemical binding]; other site 1114958006648 active site 1114958006649 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006650 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006651 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006652 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006653 active site 1114958006654 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006655 putative NADP binding site [chemical binding]; other site 1114958006656 active site 1114958006657 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006658 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006659 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006660 active site 1114958006661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958006662 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006663 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006664 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006665 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006666 active site 1114958006667 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006668 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006669 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006670 putative NADP binding site [chemical binding]; other site 1114958006671 active site 1114958006672 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006673 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006674 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1114958006675 active site 1114958006676 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006677 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006678 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006679 active site 1114958006680 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006681 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006682 putative NADP binding site [chemical binding]; other site 1114958006683 active site 1114958006684 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114958006685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006686 NAD(P) binding site [chemical binding]; other site 1114958006687 active site 1114958006688 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114958006689 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958006690 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958006691 biosynthesis cluster domain; Region: biosyn_clust_1; cl14822 1114958006692 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1114958006693 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958006694 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1114958006695 FMN binding site [chemical binding]; other site 1114958006696 substrate binding site [chemical binding]; other site 1114958006697 putative catalytic residue [active] 1114958006698 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1114958006699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958006700 Helix-turn-helix domains; Region: HTH; cl00088 1114958006701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958006702 dimerization interface [polypeptide binding]; other site 1114958006703 GlpM protein; Region: GlpM; cl01212 1114958006704 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1114958006705 active site 1114958006706 FMN binding site [chemical binding]; other site 1114958006707 substrate binding site [chemical binding]; other site 1114958006708 homotetramer interface [polypeptide binding]; other site 1114958006709 catalytic residue [active] 1114958006710 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958006711 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1114958006712 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958006713 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1114958006714 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1114958006715 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1114958006716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006717 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1114958006718 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1114958006719 DNA polymerase IV; Validated; Region: PRK01810 1114958006720 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1114958006721 active site 1114958006722 DNA binding site [nucleotide binding] 1114958006723 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1114958006724 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1114958006725 peptidase T-like protein; Region: PepT-like; TIGR01883 1114958006726 metal binding site [ion binding]; metal-binding site 1114958006727 putative dimer interface [polypeptide binding]; other site 1114958006728 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1114958006729 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114958006730 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114958006731 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958006732 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1114958006733 dimer interface [polypeptide binding]; other site 1114958006734 substrate binding site [chemical binding]; other site 1114958006735 metal binding site [ion binding]; metal-binding site 1114958006736 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1114958006737 Predicted membrane protein [Function unknown]; Region: COG4129 1114958006738 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1114958006739 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1114958006740 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958006741 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114958006742 Walker A/P-loop; other site 1114958006743 ATP binding site [chemical binding]; other site 1114958006744 Q-loop/lid; other site 1114958006745 ABC transporter signature motif; other site 1114958006746 Walker B; other site 1114958006747 D-loop; other site 1114958006748 H-loop/switch region; other site 1114958006749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114958006750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958006751 dimer interface [polypeptide binding]; other site 1114958006752 conserved gate region; other site 1114958006753 putative PBP binding loops; other site 1114958006754 ABC-ATPase subunit interface; other site 1114958006755 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958006756 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114958006757 substrate binding pocket [chemical binding]; other site 1114958006758 membrane-bound complex binding site; other site 1114958006759 hinge residues; other site 1114958006760 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1114958006761 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1114958006762 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1114958006763 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114958006764 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114958006765 E3 interaction surface; other site 1114958006766 lipoyl attachment site [posttranslational modification]; other site 1114958006767 e3 binding domain; Region: E3_binding; pfam02817 1114958006768 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1114958006769 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114958006770 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114958006771 alpha subunit interface [polypeptide binding]; other site 1114958006772 TPP binding site [chemical binding]; other site 1114958006773 heterodimer interface [polypeptide binding]; other site 1114958006774 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958006775 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1114958006776 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114958006777 tetramer interface [polypeptide binding]; other site 1114958006778 TPP-binding site [chemical binding]; other site 1114958006779 heterodimer interface [polypeptide binding]; other site 1114958006780 phosphorylation loop region [posttranslational modification] 1114958006781 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1114958006782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958006784 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114958006785 Acetokinase family; Region: Acetate_kinase; cl01029 1114958006786 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1114958006787 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114958006788 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1114958006789 NAD binding site [chemical binding]; other site 1114958006790 Phe binding site; other site 1114958006791 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1114958006792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006793 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1114958006794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958006795 putative active site [active] 1114958006796 heme pocket [chemical binding]; other site 1114958006797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958006798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958006799 Walker A motif; other site 1114958006800 ATP binding site [chemical binding]; other site 1114958006801 Walker B motif; other site 1114958006802 arginine finger; other site 1114958006803 Helix-turn-helix domains; Region: HTH; cl00088 1114958006804 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1114958006805 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1114958006806 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114958006807 tetramer interface [polypeptide binding]; other site 1114958006808 active site 1114958006809 Mg2+/Mn2+ binding site [ion binding]; other site 1114958006810 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1114958006811 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1114958006812 dimer interface [polypeptide binding]; other site 1114958006813 Citrate synthase; Region: Citrate_synt; pfam00285 1114958006814 active site 1114958006815 coenzyme A binding site [chemical binding]; other site 1114958006816 citrylCoA binding site [chemical binding]; other site 1114958006817 oxalacetate/citrate binding site [chemical binding]; other site 1114958006818 catalytic triad [active] 1114958006819 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114958006820 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1114958006821 FAD binding site [chemical binding]; other site 1114958006822 homotetramer interface [polypeptide binding]; other site 1114958006823 substrate binding pocket [chemical binding]; other site 1114958006824 catalytic base [active] 1114958006825 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1114958006826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006827 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114958006828 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1114958006829 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114958006830 dimer interface [polypeptide binding]; other site 1114958006831 active site 1114958006832 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1114958006833 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1114958006834 active site 1114958006835 catalytic site [active] 1114958006836 metal binding site [ion binding]; metal-binding site 1114958006837 dimer interface [polypeptide binding]; other site 1114958006838 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958006839 active site 1114958006840 metal binding site [ion binding]; metal-binding site 1114958006841 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1114958006842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958006843 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1114958006844 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1114958006845 putative active site [active] 1114958006846 putative FMN binding site [chemical binding]; other site 1114958006847 putative substrate binding site [chemical binding]; other site 1114958006848 putative catalytic residue [active] 1114958006849 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958006850 alanine racemase; Region: alr; TIGR00492 1114958006851 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1114958006852 active site 1114958006853 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114958006854 dimer interface [polypeptide binding]; other site 1114958006855 substrate binding site [chemical binding]; other site 1114958006856 catalytic residues [active] 1114958006857 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1114958006858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958006859 active site 1114958006860 phosphorylation site [posttranslational modification] 1114958006861 intermolecular recognition site; other site 1114958006862 dimerization interface [polypeptide binding]; other site 1114958006863 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1114958006864 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1114958006865 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114958006866 protein binding site [polypeptide binding]; other site 1114958006867 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1114958006868 DNA repair protein RecN; Region: recN; TIGR00634 1114958006869 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1114958006870 Walker A/P-loop; other site 1114958006871 ATP binding site [chemical binding]; other site 1114958006872 Q-loop/lid; other site 1114958006873 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1114958006874 ABC transporter signature motif; other site 1114958006875 Walker B; other site 1114958006876 D-loop; other site 1114958006877 H-loop/switch region; other site 1114958006878 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1114958006879 arginine repressor; Provisional; Region: PRK04280 1114958006880 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1114958006881 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1114958006882 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958006883 RNA binding surface [nucleotide binding]; other site 1114958006884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958006885 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1114958006886 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1114958006887 TPP-binding site; other site 1114958006888 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114958006889 PYR/PP interface [polypeptide binding]; other site 1114958006890 dimer interface [polypeptide binding]; other site 1114958006891 TPP binding site [chemical binding]; other site 1114958006892 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958006893 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114958006894 substrate binding pocket [chemical binding]; other site 1114958006895 chain length determination region; other site 1114958006896 substrate-Mg2+ binding site; other site 1114958006897 catalytic residues [active] 1114958006898 aspartate-rich region 1; other site 1114958006899 active site lid residues [active] 1114958006900 aspartate-rich region 2; other site 1114958006901 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1114958006902 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1114958006903 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1114958006904 generic binding surface II; other site 1114958006905 generic binding surface I; other site 1114958006906 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1114958006907 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1114958006908 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114958006909 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114958006910 homodimer interface [polypeptide binding]; other site 1114958006911 NADP binding site [chemical binding]; other site 1114958006912 substrate binding site [chemical binding]; other site 1114958006913 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1114958006914 putative RNA binding site [nucleotide binding]; other site 1114958006915 Asp23 family; Region: Asp23; cl00574 1114958006916 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1114958006917 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958006918 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1114958006919 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1114958006920 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114958006921 carboxyltransferase (CT) interaction site; other site 1114958006922 biotinylation site [posttranslational modification]; other site 1114958006923 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1114958006924 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1114958006925 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 1114958006926 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1114958006927 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1114958006928 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1114958006929 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1114958006930 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 1114958006931 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1114958006932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958006933 Walker A motif; other site 1114958006934 ATP binding site [chemical binding]; other site 1114958006935 Walker B motif; other site 1114958006936 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1114958006937 elongation factor P; Validated; Region: PRK00529 1114958006938 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1114958006939 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1114958006940 RNA binding site [nucleotide binding]; other site 1114958006941 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1114958006942 RNA binding site [nucleotide binding]; other site 1114958006943 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1114958006944 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114958006945 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1114958006946 active site 1114958006947 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1114958006948 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 1114958006949 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114958006950 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1114958006951 active site 1114958006952 nucleophile elbow; other site 1114958006953 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1114958006954 Helix-turn-helix domains; Region: HTH; cl00088 1114958006955 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1114958006956 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1114958006957 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1114958006958 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114958006959 active site residue [active] 1114958006960 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 1114958006961 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114958006962 tetramer interface [polypeptide binding]; other site 1114958006963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006964 catalytic residue [active] 1114958006965 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 1114958006966 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114958006967 tetramer interface [polypeptide binding]; other site 1114958006968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006969 catalytic residue [active] 1114958006970 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1114958006971 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1114958006972 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114958006973 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114958006974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958006975 ATP binding site [chemical binding]; other site 1114958006976 putative Mg++ binding site [ion binding]; other site 1114958006977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958006978 nucleotide binding region [chemical binding]; other site 1114958006979 ATP-binding site [chemical binding]; other site 1114958006980 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1114958006981 Anti-repressor SinI; Region: SinI; pfam08671 1114958006982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958006983 non-specific DNA binding site [nucleotide binding]; other site 1114958006984 salt bridge; other site 1114958006985 sequence-specific DNA binding site [nucleotide binding]; other site 1114958006986 Anti-repressor SinI; Region: SinI; pfam08671 1114958006987 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1114958006988 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114958006989 Catalytic site [active] 1114958006990 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1114958006991 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1114958006992 YqzE-like protein; Region: YqzE; pfam14038 1114958006993 ComG operon protein 7; Region: ComGG; pfam14173 1114958006994 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1114958006995 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1114958006996 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1114958006997 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114958006998 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1114958006999 Type II/IV secretion system protein; Region: T2SE; pfam00437 1114958007000 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1114958007001 Walker A motif; other site 1114958007002 ATP binding site [chemical binding]; other site 1114958007003 Walker B motif; other site 1114958007004 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1114958007005 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1114958007006 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114958007007 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114958007008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114958007009 Transporter associated domain; Region: CorC_HlyC; cl08393 1114958007010 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958007011 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1114958007012 ArsC family; Region: ArsC; pfam03960 1114958007013 putative catalytic residues [active] 1114958007014 thiol/disulfide switch; other site 1114958007015 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1114958007016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958007017 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1114958007018 Domain of unknown function DUF77; Region: DUF77; cl00307 1114958007019 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1114958007020 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1114958007021 putative active site [active] 1114958007022 Zn binding site [ion binding]; other site 1114958007023 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1114958007024 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1114958007025 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 1114958007026 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1114958007027 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1114958007028 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1114958007029 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1114958007030 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 1114958007031 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1114958007032 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1114958007033 Walker A/P-loop; other site 1114958007034 ATP binding site [chemical binding]; other site 1114958007035 Q-loop/lid; other site 1114958007036 ABC transporter signature motif; other site 1114958007037 Walker B; other site 1114958007038 D-loop; other site 1114958007039 H-loop/switch region; other site 1114958007040 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1114958007041 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1114958007042 Walker A/P-loop; other site 1114958007043 ATP binding site [chemical binding]; other site 1114958007044 Q-loop/lid; other site 1114958007045 ABC transporter signature motif; other site 1114958007046 Walker B; other site 1114958007047 D-loop; other site 1114958007048 H-loop/switch region; other site 1114958007049 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1114958007050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007051 dimer interface [polypeptide binding]; other site 1114958007052 conserved gate region; other site 1114958007053 ABC-ATPase subunit interface; other site 1114958007054 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1114958007055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007056 dimer interface [polypeptide binding]; other site 1114958007057 conserved gate region; other site 1114958007058 putative PBP binding loops; other site 1114958007059 ABC-ATPase subunit interface; other site 1114958007060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114958007061 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114958007062 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1114958007063 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958007064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958007065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007066 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1114958007067 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114958007068 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114958007069 Protein of unknown function (DUF456); Region: DUF456; cl01069 1114958007070 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1114958007071 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 1114958007072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1114958007073 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114958007074 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114958007075 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958007076 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114958007077 metal binding site 2 [ion binding]; metal-binding site 1114958007078 putative DNA binding helix; other site 1114958007079 metal binding site 1 [ion binding]; metal-binding site 1114958007080 dimer interface [polypeptide binding]; other site 1114958007081 structural Zn2+ binding site [ion binding]; other site 1114958007082 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958007083 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958007084 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1114958007085 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1114958007086 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1114958007087 Metal-binding active site; metal-binding site 1114958007088 AP (apurinic/apyrimidinic) site pocket; other site 1114958007089 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114958007090 DNA interaction; other site 1114958007091 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114958007092 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114958007093 ATP binding site [chemical binding]; other site 1114958007094 Mg++ binding site [ion binding]; other site 1114958007095 motif III; other site 1114958007096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958007097 nucleotide binding region [chemical binding]; other site 1114958007098 ATP-binding site [chemical binding]; other site 1114958007099 YqfQ-like protein; Region: YqfQ; pfam14181 1114958007100 LytB protein; Region: LYTB; cl00507 1114958007101 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1114958007102 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1114958007103 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1114958007104 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1114958007105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958007106 Cytochrome c; Region: Cytochrom_C; cl11414 1114958007107 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1114958007108 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1114958007109 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114958007110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958007111 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958007112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958007113 DNA binding residues [nucleotide binding] 1114958007114 DNA primase; Validated; Region: dnaG; PRK05667 1114958007115 CHC2 zinc finger; Region: zf-CHC2; cl15369 1114958007116 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1114958007117 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1114958007118 active site 1114958007119 metal binding site [ion binding]; metal-binding site 1114958007120 interdomain interaction site; other site 1114958007121 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1114958007122 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1114958007123 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 1114958007124 Helix-turn-helix domains; Region: HTH; cl00088 1114958007125 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1114958007126 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958007127 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1114958007128 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114958007129 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1114958007130 dimer interface [polypeptide binding]; other site 1114958007131 motif 1; other site 1114958007132 active site 1114958007133 motif 2; other site 1114958007134 motif 3; other site 1114958007135 Recombination protein O N terminal; Region: RecO_N; cl15812 1114958007136 DNA repair protein RecO; Region: reco; TIGR00613 1114958007137 Recombination protein O C terminal; Region: RecO_C; pfam02565 1114958007138 GTPase Era; Reviewed; Region: era; PRK00089 1114958007139 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1114958007140 G1 box; other site 1114958007141 GTP/Mg2+ binding site [chemical binding]; other site 1114958007142 Switch I region; other site 1114958007143 G2 box; other site 1114958007144 Switch II region; other site 1114958007145 G3 box; other site 1114958007146 G4 box; other site 1114958007147 G5 box; other site 1114958007148 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1114958007149 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1114958007150 active site 1114958007151 catalytic motif [active] 1114958007152 Zn binding site [ion binding]; other site 1114958007153 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 1114958007154 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1114958007155 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1114958007156 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1114958007157 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958007158 Zn2+ binding site [ion binding]; other site 1114958007159 Mg2+ binding site [ion binding]; other site 1114958007160 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1114958007161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958007162 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1114958007163 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1114958007164 YabP family; Region: YabP; cl06766 1114958007165 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 1114958007166 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1114958007167 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1114958007168 dimer interface [polypeptide binding]; other site 1114958007169 active site residues [active] 1114958007170 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1114958007171 GatB domain; Region: GatB_Yqey; cl11497 1114958007172 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 1114958007173 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1114958007174 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1114958007175 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1114958007176 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 1114958007177 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114958007178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958007179 FeS/SAM binding site; other site 1114958007180 TRAM domain; Region: TRAM; cl01282 1114958007181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1114958007182 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1114958007183 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1114958007184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958007185 S-adenosylmethionine binding site [chemical binding]; other site 1114958007186 chaperone protein DnaJ; Provisional; Region: PRK14280 1114958007187 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114958007188 HSP70 interaction site [polypeptide binding]; other site 1114958007189 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1114958007190 substrate binding site [polypeptide binding]; other site 1114958007191 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1114958007192 Zn binding sites [ion binding]; other site 1114958007193 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114958007194 dimer interface [polypeptide binding]; other site 1114958007195 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1114958007196 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1114958007197 dimer interface [polypeptide binding]; other site 1114958007198 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1114958007199 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1114958007200 Helix-turn-helix domains; Region: HTH; cl00088 1114958007201 HrcA protein C terminal domain; Region: HrcA; pfam01628 1114958007202 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1114958007203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958007204 FeS/SAM binding site; other site 1114958007205 HemN C-terminal domain; Region: HemN_C; pfam06969 1114958007206 GTP-binding protein LepA; Provisional; Region: PRK05433 1114958007207 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1114958007208 G1 box; other site 1114958007209 putative GEF interaction site [polypeptide binding]; other site 1114958007210 GTP/Mg2+ binding site [chemical binding]; other site 1114958007211 Switch I region; other site 1114958007212 G2 box; other site 1114958007213 G3 box; other site 1114958007214 Switch II region; other site 1114958007215 G4 box; other site 1114958007216 G5 box; other site 1114958007217 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1114958007218 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1114958007219 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1114958007220 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1114958007221 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1114958007222 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1114958007223 Germination protease; Region: Peptidase_A25; cl04057 1114958007224 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1114958007225 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1114958007226 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1114958007227 YqzM-like protein; Region: YqzM; pfam14141 1114958007228 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1114958007229 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1114958007230 Competence protein; Region: Competence; cl00471 1114958007231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958007232 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1114958007233 catalytic motif [active] 1114958007234 Zn binding site [ion binding]; other site 1114958007235 SLBB domain; Region: SLBB; pfam10531 1114958007236 comEA protein; Region: comE; TIGR01259 1114958007237 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1114958007238 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1114958007239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958007240 NAD(P) binding pocket [chemical binding]; other site 1114958007241 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1114958007242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958007243 S-adenosylmethionine binding site [chemical binding]; other site 1114958007244 Oligomerisation domain; Region: Oligomerisation; cl00519 1114958007245 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 1114958007246 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958007247 Zn2+ binding site [ion binding]; other site 1114958007248 Mg2+ binding site [ion binding]; other site 1114958007249 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1114958007250 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1114958007251 active site 1114958007252 (T/H)XGH motif; other site 1114958007253 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1114958007254 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1114958007255 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114958007256 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114958007257 shikimate binding site; other site 1114958007258 NAD(P) binding site [chemical binding]; other site 1114958007259 GTPase YqeH; Provisional; Region: PRK13796 1114958007260 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1114958007261 GTP/Mg2+ binding site [chemical binding]; other site 1114958007262 G4 box; other site 1114958007263 G5 box; other site 1114958007264 G1 box; other site 1114958007265 Switch I region; other site 1114958007266 G2 box; other site 1114958007267 G3 box; other site 1114958007268 Switch II region; other site 1114958007269 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1114958007270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958007271 active site 1114958007272 motif I; other site 1114958007273 motif II; other site 1114958007274 Sporulation inhibitor A; Region: Sda; pfam08970 1114958007275 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1114958007276 active site 1114958007277 catalytic triad [active] 1114958007278 oxyanion hole [active] 1114958007279 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1114958007280 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114958007281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007282 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958007283 putative substrate translocation pore; other site 1114958007284 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1114958007285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958007286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958007287 DNA binding residues [nucleotide binding] 1114958007288 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1114958007289 Helix-turn-helix domains; Region: HTH; cl00088 1114958007290 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958007291 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1114958007292 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114958007293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958007294 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1114958007295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958007297 putative substrate translocation pore; other site 1114958007298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958007300 Coenzyme A binding pocket [chemical binding]; other site 1114958007301 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114958007302 DinB superfamily; Region: DinB_2; pfam12867 1114958007303 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958007304 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958007305 active site 1114958007306 motif I; other site 1114958007307 motif II; other site 1114958007308 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958007309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958007310 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958007311 active site 1114958007312 motif I; other site 1114958007313 motif II; other site 1114958007314 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958007315 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114958007316 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114958007317 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114958007318 putative active site [active] 1114958007319 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1114958007320 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1114958007321 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1114958007322 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114958007323 active site 1114958007324 P-loop; other site 1114958007325 phosphorylation site [posttranslational modification] 1114958007326 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958007327 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958007328 active site 1114958007329 phosphorylation site [posttranslational modification] 1114958007330 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114958007331 Helix-turn-helix domains; Region: HTH; cl00088 1114958007332 Helix-turn-helix domains; Region: HTH; cl00088 1114958007333 PRD domain; Region: PRD; cl15445 1114958007334 PRD domain; Region: PRD; cl15445 1114958007335 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1114958007336 active site 1114958007337 P-loop; other site 1114958007338 phosphorylation site [posttranslational modification] 1114958007339 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958007340 active site 1114958007341 phosphorylation site [posttranslational modification] 1114958007342 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958007343 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1114958007344 putative deacylase active site [active] 1114958007345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958007346 Helix-turn-helix domains; Region: HTH; cl00088 1114958007347 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1114958007348 putative dimerization interface [polypeptide binding]; other site 1114958007349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007350 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958007351 putative substrate translocation pore; other site 1114958007352 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1114958007353 Cytochrome P450; Region: p450; pfam00067 1114958007354 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1114958007355 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958007356 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1114958007357 FAD binding pocket [chemical binding]; other site 1114958007358 FAD binding motif [chemical binding]; other site 1114958007359 catalytic residues [active] 1114958007360 NAD binding pocket [chemical binding]; other site 1114958007361 phosphate binding motif [ion binding]; other site 1114958007362 beta-alpha-beta structure motif; other site 1114958007363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958007364 Helix-turn-helix domains; Region: HTH; cl00088 1114958007365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958007366 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1114958007367 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1114958007368 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1114958007369 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1114958007370 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114958007371 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1114958007372 4Fe-4S binding domain; Region: Fer4; cl02805 1114958007373 4Fe-4S binding domain; Region: Fer4; cl02805 1114958007374 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1114958007375 [4Fe-4S] binding site [ion binding]; other site 1114958007376 molybdopterin cofactor binding site; other site 1114958007377 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1114958007378 molybdopterin cofactor binding site; other site 1114958007379 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1114958007380 YrhC-like protein; Region: YrhC; pfam14143 1114958007381 cystathionine beta-lyase; Provisional; Region: PRK07671 1114958007382 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114958007383 homodimer interface [polypeptide binding]; other site 1114958007384 substrate-cofactor binding pocket; other site 1114958007385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958007386 catalytic residue [active] 1114958007387 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114958007388 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114958007389 dimer interface [polypeptide binding]; other site 1114958007390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958007391 catalytic residue [active] 1114958007392 5'-methylthioadenosine nucleosidase; Region: PLN02584 1114958007393 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1114958007394 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1114958007395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958007396 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1114958007397 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1114958007398 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114958007399 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958007400 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958007401 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1114958007402 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1114958007403 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114958007404 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1114958007405 ATP-binding site [chemical binding]; other site 1114958007406 Sugar specificity; other site 1114958007407 Pyrimidine base specificity; other site 1114958007408 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1114958007409 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1114958007410 Peptidase family U32; Region: Peptidase_U32; cl03113 1114958007411 Peptidase family U32; Region: Peptidase_U32; cl03113 1114958007412 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1114958007413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958007414 S-adenosylmethionine binding site [chemical binding]; other site 1114958007415 YceG-like family; Region: YceG; pfam02618 1114958007416 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1114958007417 dimerization interface [polypeptide binding]; other site 1114958007418 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1114958007419 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1114958007420 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 1114958007421 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1114958007422 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1114958007423 motif 1; other site 1114958007424 active site 1114958007425 motif 2; other site 1114958007426 motif 3; other site 1114958007427 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1114958007428 DHHA1 domain; Region: DHHA1; pfam02272 1114958007429 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958007430 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114958007431 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958007432 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114958007433 Walker A/P-loop; other site 1114958007434 ATP binding site [chemical binding]; other site 1114958007435 Q-loop/lid; other site 1114958007436 ABC transporter signature motif; other site 1114958007437 Walker B; other site 1114958007438 D-loop; other site 1114958007439 H-loop/switch region; other site 1114958007440 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114958007441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958007442 substrate binding pocket [chemical binding]; other site 1114958007443 membrane-bound complex binding site; other site 1114958007444 hinge residues; other site 1114958007445 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114958007446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007447 dimer interface [polypeptide binding]; other site 1114958007448 conserved gate region; other site 1114958007449 putative PBP binding loops; other site 1114958007450 ABC-ATPase subunit interface; other site 1114958007451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007452 dimer interface [polypeptide binding]; other site 1114958007453 conserved gate region; other site 1114958007454 putative PBP binding loops; other site 1114958007455 ABC-ATPase subunit interface; other site 1114958007456 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1114958007457 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1114958007458 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1114958007459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958007460 Family description; Region: UvrD_C_2; cl15862 1114958007461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958007462 binding surface 1114958007463 TPR motif; other site 1114958007464 TPR repeat; Region: TPR_11; pfam13414 1114958007465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958007466 binding surface 1114958007467 TPR motif; other site 1114958007468 TPR repeat; Region: TPR_11; pfam13414 1114958007469 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1114958007470 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1114958007471 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958007472 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1114958007473 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958007474 catalytic residue [active] 1114958007475 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958007476 Helix-turn-helix domains; Region: HTH; cl00088 1114958007477 recombination factor protein RarA; Reviewed; Region: PRK13342 1114958007478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007479 Walker A motif; other site 1114958007480 ATP binding site [chemical binding]; other site 1114958007481 Walker B motif; other site 1114958007482 arginine finger; other site 1114958007483 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1114958007484 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1114958007485 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1114958007486 putative ATP binding site [chemical binding]; other site 1114958007487 putative substrate interface [chemical binding]; other site 1114958007488 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1114958007489 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1114958007490 dimer interface [polypeptide binding]; other site 1114958007491 anticodon binding site; other site 1114958007492 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1114958007493 homodimer interface [polypeptide binding]; other site 1114958007494 motif 1; other site 1114958007495 active site 1114958007496 motif 2; other site 1114958007497 GAD domain; Region: GAD; pfam02938 1114958007498 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1114958007499 motif 3; other site 1114958007500 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1114958007501 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1114958007502 dimer interface [polypeptide binding]; other site 1114958007503 motif 1; other site 1114958007504 active site 1114958007505 motif 2; other site 1114958007506 motif 3; other site 1114958007507 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1114958007508 anticodon binding site; other site 1114958007509 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1114958007510 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958007511 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958007512 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958007513 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958007514 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958007515 active site 1114958007516 metal binding site [ion binding]; metal-binding site 1114958007517 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1114958007518 putative active site [active] 1114958007519 dimerization interface [polypeptide binding]; other site 1114958007520 putative tRNAtyr binding site [nucleotide binding]; other site 1114958007521 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1114958007522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114958007523 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114958007524 synthetase active site [active] 1114958007525 NTP binding site [chemical binding]; other site 1114958007526 metal binding site [ion binding]; metal-binding site 1114958007527 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1114958007528 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1114958007529 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 1114958007530 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958007531 active site 1114958007532 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1114958007533 DHH family; Region: DHH; pfam01368 1114958007534 DHHA1 domain; Region: DHHA1; pfam02272 1114958007535 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1114958007536 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1114958007537 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1114958007538 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114958007539 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1114958007540 Protein export membrane protein; Region: SecD_SecF; cl14618 1114958007541 RDD family; Region: RDD; cl00746 1114958007542 Protein export membrane protein; Region: SecD_SecF; cl14618 1114958007543 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1114958007544 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1114958007545 MatE; Region: MatE; cl10513 1114958007546 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114958007547 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 1114958007548 Preprotein translocase subunit; Region: YajC; cl00806 1114958007549 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1114958007550 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 1114958007551 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1114958007552 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1114958007553 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1114958007554 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1114958007555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007556 Walker A motif; other site 1114958007557 ATP binding site [chemical binding]; other site 1114958007558 Walker B motif; other site 1114958007559 arginine finger; other site 1114958007560 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1114958007561 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1114958007562 RuvA N terminal domain; Region: RuvA_N; pfam01330 1114958007563 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1114958007564 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1114958007565 BofC C-terminal domain; Region: BofC_C; pfam08955 1114958007566 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1114958007567 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958007568 putative peptidoglycan binding site; other site 1114958007569 Quinolinate synthetase A protein; Region: NadA; cl00420 1114958007570 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1114958007571 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1114958007572 dimerization interface [polypeptide binding]; other site 1114958007573 active site 1114958007574 L-aspartate oxidase; Provisional; Region: PRK08071 1114958007575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958007576 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114958007577 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958007578 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1114958007579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958007580 catalytic residue [active] 1114958007581 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1114958007582 Helix-turn-helix domains; Region: HTH; cl00088 1114958007583 3H domain; Region: 3H; pfam02829 1114958007584 prephenate dehydratase; Provisional; Region: PRK11898 1114958007585 Prephenate dehydratase; Region: PDT; pfam00800 1114958007586 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1114958007587 putative L-Phe binding site [chemical binding]; other site 1114958007588 hypothetical protein; Provisional; Region: PRK04435 1114958007589 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1114958007590 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1114958007591 GTP1/OBG; Region: GTP1_OBG; pfam01018 1114958007592 Obg GTPase; Region: Obg; cd01898 1114958007593 G1 box; other site 1114958007594 GTP/Mg2+ binding site [chemical binding]; other site 1114958007595 Switch I region; other site 1114958007596 G2 box; other site 1114958007597 G3 box; other site 1114958007598 Switch II region; other site 1114958007599 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958007600 G4 box; other site 1114958007601 G4 box; other site 1114958007602 G5 box; other site 1114958007603 G5 box; other site 1114958007604 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1114958007605 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1114958007606 Protein of unknown function (DUF464); Region: DUF464; cl01080 1114958007607 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1114958007608 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1114958007609 active site 1114958007610 putative substrate binding region [chemical binding]; other site 1114958007611 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114958007612 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1114958007613 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1114958007614 Switch I; other site 1114958007615 Switch II; other site 1114958007616 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1114958007617 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1114958007618 rod shape-determining protein MreD; Region: MreD; cl01087 1114958007619 rod shape-determining protein MreC; Region: mreC; TIGR00219 1114958007620 rod shape-determining protein MreC; Region: MreC; pfam04085 1114958007621 rod shape-determining protein MreB; Provisional; Region: PRK13927 1114958007622 Cell division protein FtsA; Region: FtsA; cl11496 1114958007623 hypothetical protein; Reviewed; Region: PRK00024 1114958007624 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1114958007625 MPN+ (JAMM) motif; other site 1114958007626 Zinc-binding site [ion binding]; other site 1114958007627 Maf-like protein; Region: Maf; pfam02545 1114958007628 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1114958007629 active site 1114958007630 dimer interface [polypeptide binding]; other site 1114958007631 Sporulation related domain; Region: SPOR; cl10051 1114958007632 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1114958007633 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1114958007634 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 1114958007635 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1114958007636 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958007637 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958007638 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1114958007639 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114958007640 active site 1114958007641 HIGH motif; other site 1114958007642 nucleotide binding site [chemical binding]; other site 1114958007643 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114958007644 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1114958007645 active site 1114958007646 KMSKS motif; other site 1114958007647 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1114958007648 tRNA binding surface [nucleotide binding]; other site 1114958007649 anticodon binding site; other site 1114958007650 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1114958007651 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958007652 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1114958007653 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1114958007654 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1114958007655 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1114958007656 putative peptidoglycan binding site; other site 1114958007657 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1114958007658 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958007659 inhibitor-cofactor binding pocket; inhibition site 1114958007660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958007661 catalytic residue [active] 1114958007662 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1114958007663 dimer interface [polypeptide binding]; other site 1114958007664 active site 1114958007665 Schiff base residues; other site 1114958007666 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114958007667 active site 1114958007668 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 1114958007669 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1114958007670 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1114958007671 domain interfaces; other site 1114958007672 active site 1114958007673 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1114958007674 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1114958007675 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1114958007676 tRNA; other site 1114958007677 putative tRNA binding site [nucleotide binding]; other site 1114958007678 putative NADP binding site [chemical binding]; other site 1114958007679 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1114958007680 Predicted GTPase [General function prediction only]; Region: COG0218 1114958007681 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1114958007682 G1 box; other site 1114958007683 GTP/Mg2+ binding site [chemical binding]; other site 1114958007684 Switch I region; other site 1114958007685 G2 box; other site 1114958007686 G3 box; other site 1114958007687 Switch II region; other site 1114958007688 G4 box; other site 1114958007689 G5 box; other site 1114958007690 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1114958007691 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1114958007692 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1114958007693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007694 Walker A motif; other site 1114958007695 ATP binding site [chemical binding]; other site 1114958007696 Walker B motif; other site 1114958007697 arginine finger; other site 1114958007698 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114958007699 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1114958007700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007701 Walker A motif; other site 1114958007702 ATP binding site [chemical binding]; other site 1114958007703 Walker B motif; other site 1114958007704 arginine finger; other site 1114958007705 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1114958007706 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1114958007707 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1114958007708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007709 Walker A motif; other site 1114958007710 ATP binding site [chemical binding]; other site 1114958007711 Walker B motif; other site 1114958007712 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1114958007713 trigger factor; Provisional; Region: tig; PRK01490 1114958007714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1114958007715 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1114958007716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958007717 binding surface 1114958007718 TPR motif; other site 1114958007719 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1114958007720 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1114958007721 substrate binding site [chemical binding]; other site 1114958007722 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1114958007723 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1114958007724 substrate binding site [chemical binding]; other site 1114958007725 ligand binding site [chemical binding]; other site 1114958007726 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114958007727 tartrate dehydrogenase; Provisional; Region: PRK08194 1114958007728 2-isopropylmalate synthase; Validated; Region: PRK00915 1114958007729 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1114958007730 active site 1114958007731 catalytic residues [active] 1114958007732 metal binding site [ion binding]; metal-binding site 1114958007733 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1114958007734 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1114958007735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958007736 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1114958007737 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1114958007738 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1114958007739 putative valine binding site [chemical binding]; other site 1114958007740 dimer interface [polypeptide binding]; other site 1114958007741 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1114958007742 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1114958007743 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114958007744 PYR/PP interface [polypeptide binding]; other site 1114958007745 dimer interface [polypeptide binding]; other site 1114958007746 TPP binding site [chemical binding]; other site 1114958007747 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114958007748 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1114958007749 TPP-binding site [chemical binding]; other site 1114958007750 dimer interface [polypeptide binding]; other site 1114958007751 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1114958007752 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958007753 active site 1114958007754 metal binding site [ion binding]; metal-binding site 1114958007755 homotetramer interface [polypeptide binding]; other site 1114958007756 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1114958007757 active site 1114958007758 dimerization interface [polypeptide binding]; other site 1114958007759 ribonuclease PH; Reviewed; Region: rph; PRK00173 1114958007760 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1114958007761 hexamer interface [polypeptide binding]; other site 1114958007762 active site 1114958007763 Sporulation and spore germination; Region: Germane; cl11253 1114958007764 Spore germination protein [General function prediction only]; Region: COG5401 1114958007765 Sporulation and spore germination; Region: Germane; cl11253 1114958007766 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114958007767 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958007768 Helix-turn-helix domains; Region: HTH; cl00088 1114958007769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958007770 DNA binding residues [nucleotide binding] 1114958007771 dimerization interface [polypeptide binding]; other site 1114958007772 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114958007773 active site 1114958007774 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1114958007775 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114958007776 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114958007777 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1114958007778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958007779 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114958007780 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1114958007781 putative Iron-sulfur protein interface [polypeptide binding]; other site 1114958007782 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1114958007783 proximal heme binding site [chemical binding]; other site 1114958007784 distal heme binding site [chemical binding]; other site 1114958007785 putative dimer interface [polypeptide binding]; other site 1114958007786 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1114958007787 aspartate kinase; Reviewed; Region: PRK06635 1114958007788 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1114958007789 putative nucleotide binding site [chemical binding]; other site 1114958007790 putative catalytic residues [active] 1114958007791 putative Mg ion binding site [ion binding]; other site 1114958007792 putative aspartate binding site [chemical binding]; other site 1114958007793 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1114958007794 putative allosteric regulatory site; other site 1114958007795 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1114958007796 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1114958007797 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114958007798 GIY-YIG motif/motif A; other site 1114958007799 active site 1114958007800 catalytic site [active] 1114958007801 putative DNA binding site [nucleotide binding]; other site 1114958007802 metal binding site [ion binding]; metal-binding site 1114958007803 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1114958007804 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958007805 catalytic residues [active] 1114958007806 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1114958007807 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1114958007808 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114958007809 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1114958007810 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114958007811 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1114958007812 Ligand binding site [chemical binding]; other site 1114958007813 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114958007814 enoyl-CoA hydratase; Provisional; Region: PRK07658 1114958007815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958007816 substrate binding site [chemical binding]; other site 1114958007817 oxyanion hole (OAH) forming residues; other site 1114958007818 trimer interface [polypeptide binding]; other site 1114958007819 Helix-turn-helix domains; Region: HTH; cl00088 1114958007820 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1114958007821 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1114958007822 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958007823 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958007824 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1114958007825 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1114958007826 Predicted membrane protein [Function unknown]; Region: COG3766 1114958007827 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1114958007828 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1114958007829 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1114958007830 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 1114958007831 Walker A/P-loop; other site 1114958007832 ATP binding site [chemical binding]; other site 1114958007833 Q-loop/lid; other site 1114958007834 ABC transporter signature motif; other site 1114958007835 Walker B; other site 1114958007836 D-loop; other site 1114958007837 H-loop/switch region; other site 1114958007838 Smr domain; Region: Smr; cl02619 1114958007839 hypothetical protein; Provisional; Region: PRK08609 1114958007840 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1114958007841 active site 1114958007842 primer binding site [nucleotide binding]; other site 1114958007843 NTP binding site [chemical binding]; other site 1114958007844 metal binding triad [ion binding]; metal-binding site 1114958007845 Colicin V production protein; Region: Colicin_V; cl00567 1114958007846 Cell division protein ZapA; Region: ZapA; cl01146 1114958007847 ribonuclease HIII; Provisional; Region: PRK00996 1114958007848 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1114958007849 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1114958007850 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114958007851 active site 1114958007852 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1114958007853 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1114958007854 putative tRNA-binding site [nucleotide binding]; other site 1114958007855 B3/4 domain; Region: B3_4; cl11458 1114958007856 tRNA synthetase B5 domain; Region: B5; cl08394 1114958007857 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1114958007858 dimer interface [polypeptide binding]; other site 1114958007859 motif 1; other site 1114958007860 motif 3; other site 1114958007861 motif 2; other site 1114958007862 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1114958007863 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1114958007864 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1114958007865 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1114958007866 dimer interface [polypeptide binding]; other site 1114958007867 motif 1; other site 1114958007868 active site 1114958007869 motif 2; other site 1114958007870 motif 3; other site 1114958007871 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1114958007872 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1114958007873 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1114958007874 Small, acid-soluble spore protein I; Region: SSPI; cl07940 1114958007875 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1114958007876 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1114958007877 Helix-turn-helix domains; Region: HTH; cl00088 1114958007878 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958007879 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1114958007880 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114958007881 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114958007882 Cysteine-rich domain; Region: CCG; pfam02754 1114958007883 Cysteine-rich domain; Region: CCG; pfam02754 1114958007884 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1114958007885 Carbon starvation protein CstA; Region: CstA; pfam02554 1114958007886 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1114958007887 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1114958007888 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1114958007889 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114958007890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007891 putative PBP binding loops; other site 1114958007892 dimer interface [polypeptide binding]; other site 1114958007893 ABC-ATPase subunit interface; other site 1114958007894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007895 dimer interface [polypeptide binding]; other site 1114958007896 conserved gate region; other site 1114958007897 putative PBP binding loops; other site 1114958007898 ABC-ATPase subunit interface; other site 1114958007899 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114958007900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114958007901 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1114958007902 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1114958007903 active site 1114958007904 metal binding site [ion binding]; metal-binding site 1114958007905 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1114958007906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958007907 active site 1114958007908 motif I; other site 1114958007909 motif II; other site 1114958007910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958007911 motif II; other site 1114958007912 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1114958007913 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1114958007914 intersubunit interface [polypeptide binding]; other site 1114958007915 active site 1114958007916 Zn2+ binding site [ion binding]; other site 1114958007917 ribulokinase; Provisional; Region: PRK04123 1114958007918 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1114958007919 putative N- and C-terminal domain interface [polypeptide binding]; other site 1114958007920 putative active site [active] 1114958007921 putative MgATP binding site [chemical binding]; other site 1114958007922 catalytic site [active] 1114958007923 metal binding site [ion binding]; metal-binding site 1114958007924 carbohydrate binding site [chemical binding]; other site 1114958007925 homodimer interface [polypeptide binding]; other site 1114958007926 L-arabinose isomerase; Provisional; Region: PRK02929 1114958007927 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1114958007928 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1114958007929 trimer interface [polypeptide binding]; other site 1114958007930 putative substrate binding site [chemical binding]; other site 1114958007931 putative metal binding site [ion binding]; other site 1114958007932 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1114958007933 substrate binding site [chemical binding]; other site 1114958007934 active site 1114958007935 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1114958007936 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1114958007937 oligomer interface [polypeptide binding]; other site 1114958007938 active site 1114958007939 metal binding site [ion binding]; metal-binding site 1114958007940 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1114958007941 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1114958007942 23S rRNA binding site [nucleotide binding]; other site 1114958007943 L21 binding site [polypeptide binding]; other site 1114958007944 L13 binding site [polypeptide binding]; other site 1114958007945 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 1114958007946 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1114958007947 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1114958007948 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1114958007949 LrgB-like family; Region: LrgB; cl00596 1114958007950 LrgA family; Region: LrgA; cl00608 1114958007951 two-component response regulator; Provisional; Region: PRK14084 1114958007952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958007953 active site 1114958007954 phosphorylation site [posttranslational modification] 1114958007955 intermolecular recognition site; other site 1114958007956 dimerization interface [polypeptide binding]; other site 1114958007957 LytTr DNA-binding domain; Region: LytTR; cl04498 1114958007958 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1114958007959 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1114958007960 GAF domain; Region: GAF; cl15785 1114958007961 Histidine kinase; Region: His_kinase; pfam06580 1114958007962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958007963 ATP binding site [chemical binding]; other site 1114958007964 Mg2+ binding site [ion binding]; other site 1114958007965 G-X-G motif; other site 1114958007966 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1114958007967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958007968 motif II; other site 1114958007969 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1114958007970 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1114958007971 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1114958007972 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1114958007973 active site 1114958007974 dimer interface [polypeptide binding]; other site 1114958007975 motif 1; other site 1114958007976 motif 2; other site 1114958007977 motif 3; other site 1114958007978 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1114958007979 anticodon binding site; other site 1114958007980 YtxC-like family; Region: YtxC; cl08500 1114958007981 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114958007982 primosomal protein DnaI; Reviewed; Region: PRK08939 1114958007983 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1114958007984 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958007985 Walker A motif; other site 1114958007986 ATP binding site [chemical binding]; other site 1114958007987 Walker B motif; other site 1114958007988 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1114958007989 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1114958007990 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1114958007991 ATP cone domain; Region: ATP-cone; pfam03477 1114958007992 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1114958007993 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1114958007994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958007995 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114958007996 Helix-turn-helix domains; Region: HTH; cl00088 1114958007997 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958007998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007999 putative substrate translocation pore; other site 1114958008000 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958008001 active site 1114958008002 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958008003 catalytic tetrad [active] 1114958008004 dephospho-CoA kinase; Region: TIGR00152 1114958008005 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1114958008006 CoA-binding site [chemical binding]; other site 1114958008007 ATP-binding [chemical binding]; other site 1114958008008 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1114958008009 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1114958008010 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1114958008011 DNA binding site [nucleotide binding] 1114958008012 catalytic residue [active] 1114958008013 H2TH interface [polypeptide binding]; other site 1114958008014 putative catalytic residues [active] 1114958008015 turnover-facilitating residue; other site 1114958008016 intercalation triad [nucleotide binding]; other site 1114958008017 8OG recognition residue [nucleotide binding]; other site 1114958008018 putative reading head residues; other site 1114958008019 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1114958008020 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1114958008021 DNA polymerase I; Provisional; Region: PRK05755 1114958008022 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1114958008023 active site 1114958008024 metal binding site 1 [ion binding]; metal-binding site 1114958008025 putative 5' ssDNA interaction site; other site 1114958008026 metal binding site 3; metal-binding site 1114958008027 metal binding site 2 [ion binding]; metal-binding site 1114958008028 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1114958008029 putative DNA binding site [nucleotide binding]; other site 1114958008030 putative metal binding site [ion binding]; other site 1114958008031 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1114958008032 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1114958008033 active site 1114958008034 DNA binding site [nucleotide binding] 1114958008035 catalytic site [active] 1114958008036 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114958008037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958008038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958008039 dimer interface [polypeptide binding]; other site 1114958008040 phosphorylation site [posttranslational modification] 1114958008041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958008042 ATP binding site [chemical binding]; other site 1114958008043 Mg2+ binding site [ion binding]; other site 1114958008044 G-X-G motif; other site 1114958008045 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958008046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958008047 active site 1114958008048 phosphorylation site [posttranslational modification] 1114958008049 intermolecular recognition site; other site 1114958008050 dimerization interface [polypeptide binding]; other site 1114958008051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958008052 DNA binding site [nucleotide binding] 1114958008053 malate dehydrogenase; Reviewed; Region: PRK06223 1114958008054 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1114958008055 NAD(P) binding site [chemical binding]; other site 1114958008056 dimer interface [polypeptide binding]; other site 1114958008057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958008058 substrate binding site [chemical binding]; other site 1114958008059 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114958008060 isocitrate dehydrogenase; Validated; Region: PRK07362 1114958008061 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1114958008062 dimer interface [polypeptide binding]; other site 1114958008063 Citrate synthase; Region: Citrate_synt; pfam00285 1114958008064 active site 1114958008065 citrylCoA binding site [chemical binding]; other site 1114958008066 oxalacetate/citrate binding site [chemical binding]; other site 1114958008067 coenzyme A binding site [chemical binding]; other site 1114958008068 catalytic triad [active] 1114958008069 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1114958008070 Protein of unknown function (DUF441); Region: DUF441; cl01041 1114958008071 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114958008072 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958008073 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 1114958008074 pyruvate kinase; Provisional; Region: PRK06354 1114958008075 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1114958008076 domain interfaces; other site 1114958008077 active site 1114958008078 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114958008079 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1114958008080 active site 1114958008081 ADP/pyrophosphate binding site [chemical binding]; other site 1114958008082 dimerization interface [polypeptide binding]; other site 1114958008083 allosteric effector site; other site 1114958008084 fructose-1,6-bisphosphate binding site; other site 1114958008085 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114958008086 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1114958008087 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1114958008088 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1114958008089 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1114958008090 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1114958008091 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114958008092 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1114958008093 putative NAD(P) binding site [chemical binding]; other site 1114958008094 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1114958008095 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1114958008096 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114958008097 generic binding surface I; other site 1114958008098 generic binding surface II; other site 1114958008099 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1114958008100 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1114958008101 DHH family; Region: DHH; pfam01368 1114958008102 DHHA1 domain; Region: DHHA1; pfam02272 1114958008103 YtpI-like protein; Region: YtpI; pfam14007 1114958008104 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1114958008105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958008106 DNA-binding site [nucleotide binding]; DNA binding site 1114958008107 DRTGG domain; Region: DRTGG; cl12147 1114958008108 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1114958008109 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1114958008110 active site 2 [active] 1114958008111 active site 1 [active] 1114958008112 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958008113 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958008114 classical (c) SDRs; Region: SDR_c; cd05233 1114958008115 NAD(P) binding site [chemical binding]; other site 1114958008116 active site 1114958008117 argininosuccinate lyase; Provisional; Region: PRK00855 1114958008118 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1114958008119 active sites [active] 1114958008120 tetramer interface [polypeptide binding]; other site 1114958008121 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1114958008122 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1114958008123 ANP binding site [chemical binding]; other site 1114958008124 Substrate Binding Site II [chemical binding]; other site 1114958008125 Substrate Binding Site I [chemical binding]; other site 1114958008126 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1114958008127 MPT binding site; other site 1114958008128 trimer interface [polypeptide binding]; other site 1114958008129 acetate kinase; Region: ackA; TIGR00016 1114958008130 Acetokinase family; Region: Acetate_kinase; cl01029 1114958008131 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1114958008132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958008133 S-adenosylmethionine binding site [chemical binding]; other site 1114958008134 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1114958008135 dimer interface [polypeptide binding]; other site 1114958008136 catalytic triad [active] 1114958008137 peroxidatic and resolving cysteines [active] 1114958008138 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1114958008139 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1114958008140 RDD family; Region: RDD; cl00746 1114958008141 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1114958008142 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1114958008143 tandem repeat interface [polypeptide binding]; other site 1114958008144 oligomer interface [polypeptide binding]; other site 1114958008145 active site residues [active] 1114958008146 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1114958008147 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1114958008148 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1114958008149 active site 1114958008150 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1114958008151 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008152 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958008153 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1114958008154 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1114958008155 THUMP domain; Region: THUMP; cl12076 1114958008156 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1114958008157 Ligand Binding Site [chemical binding]; other site 1114958008158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958008159 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1114958008160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958008161 catalytic residue [active] 1114958008162 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1114958008163 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1114958008164 TMPIT-like protein; Region: TMPIT; pfam07851 1114958008165 histidinol-phosphatase; Reviewed; Region: PRK08123 1114958008166 PHP-associated; Region: PHP_C; pfam13263 1114958008167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958008168 Helix-turn-helix domains; Region: HTH; cl00088 1114958008169 GAF domain; Region: GAF; cl15785 1114958008170 GAF domain; Region: GAF_2; pfam13185 1114958008171 GAF domain; Region: GAF; cl15785 1114958008172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114958008173 metal binding site [ion binding]; metal-binding site 1114958008174 active site 1114958008175 I-site; other site 1114958008176 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1114958008177 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1114958008178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958008179 RNA binding surface [nucleotide binding]; other site 1114958008180 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1114958008181 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114958008182 NAD(P) binding site [chemical binding]; other site 1114958008183 catalytic residues [active] 1114958008184 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1114958008185 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1114958008186 heme-binding site [chemical binding]; other site 1114958008187 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1114958008188 FAD binding pocket [chemical binding]; other site 1114958008189 FAD binding motif [chemical binding]; other site 1114958008190 phosphate binding motif [ion binding]; other site 1114958008191 beta-alpha-beta structure motif; other site 1114958008192 NAD binding pocket [chemical binding]; other site 1114958008193 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114958008194 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1114958008195 proposed catalytic triad [active] 1114958008196 conserved cys residue [active] 1114958008197 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1114958008198 active site 1114958008199 catalytic triad [active] 1114958008200 oxyanion hole [active] 1114958008201 Cytochrome c/c1 heme lyase; Region: Cyto_heme_lyase; pfam01265 1114958008202 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114958008203 Cation efflux family; Region: Cation_efflux; cl00316 1114958008204 Predicted transcriptional regulators [Transcription]; Region: COG1378 1114958008205 Helix-turn-helix domains; Region: HTH; cl00088 1114958008206 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1114958008207 C-terminal domain interface [polypeptide binding]; other site 1114958008208 sugar binding site [chemical binding]; other site 1114958008209 AzlC protein; Region: AzlC; cl00570 1114958008210 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1114958008211 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1114958008212 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1114958008213 active site 1114958008214 HIGH motif; other site 1114958008215 dimer interface [polypeptide binding]; other site 1114958008216 KMSKS motif; other site 1114958008217 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958008218 RNA binding surface [nucleotide binding]; other site 1114958008219 acetyl-CoA synthetase; Provisional; Region: PRK04319 1114958008220 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1114958008221 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008222 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958008223 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958008224 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958008225 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1114958008226 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1114958008227 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1114958008228 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1114958008229 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114958008230 flagellar motor protein MotS; Reviewed; Region: PRK06925 1114958008231 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114958008232 ligand binding site [chemical binding]; other site 1114958008233 flagellar motor protein MotP; Reviewed; Region: PRK06926 1114958008234 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114958008235 catabolite control protein A; Region: ccpA; TIGR01481 1114958008236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958008237 DNA binding site [nucleotide binding] 1114958008238 domain linker motif; other site 1114958008239 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1114958008240 dimerization interface [polypeptide binding]; other site 1114958008241 effector binding site; other site 1114958008242 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1114958008243 Chorismate mutase type II; Region: CM_2; cl00693 1114958008244 NeuB family; Region: NeuB; cl00496 1114958008245 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114958008246 YtxH-like protein; Region: YtxH; cl02079 1114958008247 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1114958008248 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1114958008249 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114958008250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958008251 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958008252 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1114958008253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958008254 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1114958008255 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1114958008256 putative tRNA-binding site [nucleotide binding]; other site 1114958008257 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1114958008258 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958008259 catalytic residues [active] 1114958008260 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 1114958008261 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1114958008262 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1114958008263 oligomer interface [polypeptide binding]; other site 1114958008264 active site 1114958008265 metal binding site [ion binding]; metal-binding site 1114958008266 Predicted small secreted protein [Function unknown]; Region: COG5584 1114958008267 malate dehydrogenase; Provisional; Region: PRK13529 1114958008268 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114958008269 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1114958008270 NAD(P) binding site [chemical binding]; other site 1114958008271 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958008272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958008273 S-adenosylmethionine binding site [chemical binding]; other site 1114958008274 YtzH-like protein; Region: YtzH; pfam14165 1114958008275 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1114958008276 active site 1114958008277 substrate binding site [chemical binding]; other site 1114958008278 ATP binding site [chemical binding]; other site 1114958008279 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958008280 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1114958008281 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1114958008282 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1114958008283 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1114958008284 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1114958008285 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114958008286 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114958008287 dimer interface [polypeptide binding]; other site 1114958008288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958008289 catalytic residue [active] 1114958008290 dipeptidase PepV; Reviewed; Region: PRK07318 1114958008291 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1114958008292 active site 1114958008293 metal binding site [ion binding]; metal-binding site 1114958008294 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114958008295 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1114958008296 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1114958008297 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114958008298 Walker A/P-loop; other site 1114958008299 ATP binding site [chemical binding]; other site 1114958008300 Q-loop/lid; other site 1114958008301 ABC transporter signature motif; other site 1114958008302 Walker B; other site 1114958008303 D-loop; other site 1114958008304 H-loop/switch region; other site 1114958008305 Helix-turn-helix domains; Region: HTH; cl00088 1114958008306 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114958008307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958008308 RNA binding surface [nucleotide binding]; other site 1114958008309 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1114958008310 active site 1114958008311 uracil binding [chemical binding]; other site 1114958008312 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1114958008313 MatE; Region: MatE; cl10513 1114958008314 MatE; Region: MatE; cl10513 1114958008315 HI0933-like protein; Region: HI0933_like; pfam03486 1114958008316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958008317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958008318 BCCT family transporter; Region: BCCT; cl00569 1114958008319 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1114958008320 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1114958008321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958008322 DNA binding site [nucleotide binding] 1114958008323 domain linker motif; other site 1114958008324 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1114958008325 putative ligand binding site [chemical binding]; other site 1114958008326 putative dimerization interface [polypeptide binding]; other site 1114958008327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114958008328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114958008329 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114958008330 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1114958008331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008332 dimer interface [polypeptide binding]; other site 1114958008333 conserved gate region; other site 1114958008334 putative PBP binding loops; other site 1114958008335 ABC-ATPase subunit interface; other site 1114958008336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114958008337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008338 dimer interface [polypeptide binding]; other site 1114958008339 conserved gate region; other site 1114958008340 putative PBP binding loops; other site 1114958008341 ABC-ATPase subunit interface; other site 1114958008342 alpha-galactosidase; Provisional; Region: PRK15076 1114958008343 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1114958008344 NAD binding site [chemical binding]; other site 1114958008345 sugar binding site [chemical binding]; other site 1114958008346 divalent metal binding site [ion binding]; other site 1114958008347 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958008348 dimer interface [polypeptide binding]; other site 1114958008349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114958008350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958008351 Coenzyme A binding pocket [chemical binding]; other site 1114958008352 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114958008353 active site residue [active] 1114958008354 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1114958008355 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1114958008356 HIGH motif; other site 1114958008357 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114958008358 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114958008359 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1114958008360 active site 1114958008361 KMSKS motif; other site 1114958008362 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1114958008363 tRNA binding surface [nucleotide binding]; other site 1114958008364 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1114958008365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958008366 PAS domain; Region: PAS_9; pfam13426 1114958008367 putative active site [active] 1114958008368 heme pocket [chemical binding]; other site 1114958008369 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958008370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958008372 putative substrate translocation pore; other site 1114958008373 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 1114958008374 FtsX-like permease family; Region: FtsX; cl15850 1114958008375 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958008376 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114958008377 Walker A/P-loop; other site 1114958008378 ATP binding site [chemical binding]; other site 1114958008379 Q-loop/lid; other site 1114958008380 ABC transporter signature motif; other site 1114958008381 Walker B; other site 1114958008382 D-loop; other site 1114958008383 H-loop/switch region; other site 1114958008384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114958008385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958008386 ATP binding site [chemical binding]; other site 1114958008387 Mg2+ binding site [ion binding]; other site 1114958008388 G-X-G motif; other site 1114958008389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958008390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958008391 active site 1114958008392 phosphorylation site [posttranslational modification] 1114958008393 intermolecular recognition site; other site 1114958008394 dimerization interface [polypeptide binding]; other site 1114958008395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958008396 DNA binding site [nucleotide binding] 1114958008397 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1114958008398 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114958008399 FtsX-like permease family; Region: FtsX; cl15850 1114958008400 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958008401 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114958008402 Walker A/P-loop; other site 1114958008403 ATP binding site [chemical binding]; other site 1114958008404 Q-loop/lid; other site 1114958008405 ABC transporter signature motif; other site 1114958008406 Walker B; other site 1114958008407 D-loop; other site 1114958008408 H-loop/switch region; other site 1114958008409 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958008410 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958008411 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958008412 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114958008413 Walker A/P-loop; other site 1114958008414 ATP binding site [chemical binding]; other site 1114958008415 Q-loop/lid; other site 1114958008416 ABC transporter signature motif; other site 1114958008417 Walker B; other site 1114958008418 D-loop; other site 1114958008419 H-loop/switch region; other site 1114958008420 Predicted transcriptional regulators [Transcription]; Region: COG1725 1114958008421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958008422 DNA-binding site [nucleotide binding]; DNA binding site 1114958008423 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1114958008424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958008425 putative DNA binding site [nucleotide binding]; other site 1114958008426 putative Zn2+ binding site [ion binding]; other site 1114958008427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008428 putative substrate translocation pore; other site 1114958008429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008430 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1114958008431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958008432 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114958008433 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1114958008434 active site 1114958008435 catalytic site [active] 1114958008436 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1114958008437 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114958008438 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958008439 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958008440 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1114958008441 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1114958008442 trimer interface [polypeptide binding]; other site 1114958008443 putative metal binding site [ion binding]; other site 1114958008444 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114958008445 Spore germination protein; Region: Spore_permease; cl15802 1114958008446 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1114958008447 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1114958008448 active site 1114958008449 dimer interface [polypeptide binding]; other site 1114958008450 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1114958008451 Ligand Binding Site [chemical binding]; other site 1114958008452 Molecular Tunnel; other site 1114958008453 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1114958008454 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1114958008455 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1114958008456 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1114958008457 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1114958008458 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1114958008459 active site 1114958008460 substrate-binding site [chemical binding]; other site 1114958008461 metal-binding site [ion binding] 1114958008462 ATP binding site [chemical binding]; other site 1114958008463 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1114958008464 Dienelactone hydrolase family; Region: DLH; pfam01738 1114958008465 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958008466 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1114958008467 NMT1-like family; Region: NMT1_2; cl15260 1114958008468 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114958008469 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1114958008470 Walker A/P-loop; other site 1114958008471 ATP binding site [chemical binding]; other site 1114958008472 Q-loop/lid; other site 1114958008473 ABC transporter signature motif; other site 1114958008474 Walker B; other site 1114958008475 D-loop; other site 1114958008476 H-loop/switch region; other site 1114958008477 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114958008478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008479 dimer interface [polypeptide binding]; other site 1114958008480 conserved gate region; other site 1114958008481 putative PBP binding loops; other site 1114958008482 ABC-ATPase subunit interface; other site 1114958008483 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1114958008484 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1114958008485 nudix motif; other site 1114958008486 Holin family; Region: Phage_holin_4; cl01989 1114958008487 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1114958008488 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1114958008489 dimerization interface [polypeptide binding]; other site 1114958008490 DPS ferroxidase diiron center [ion binding]; other site 1114958008491 ion pore; other site 1114958008492 FixH; Region: FixH; cl01254 1114958008493 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1114958008494 Haemolytic domain; Region: Haemolytic; cl00506 1114958008495 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1114958008496 active site clefts [active] 1114958008497 zinc binding site [ion binding]; other site 1114958008498 dimer interface [polypeptide binding]; other site 1114958008499 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1114958008500 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1114958008501 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1114958008502 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1114958008503 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1114958008504 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1114958008505 active site 1114958008506 octamer interface [polypeptide binding]; other site 1114958008507 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1114958008508 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958008510 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114958008511 substrate binding site [chemical binding]; other site 1114958008512 oxyanion hole (OAH) forming residues; other site 1114958008513 trimer interface [polypeptide binding]; other site 1114958008514 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1114958008515 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1114958008516 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1114958008517 dimer interface [polypeptide binding]; other site 1114958008518 tetramer interface [polypeptide binding]; other site 1114958008519 PYR/PP interface [polypeptide binding]; other site 1114958008520 TPP binding site [chemical binding]; other site 1114958008521 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1114958008522 TPP-binding site; other site 1114958008523 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1114958008524 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114958008525 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1114958008526 TspO/MBR family; Region: TspO_MBR; cl01379 1114958008527 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1114958008528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1114958008529 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1114958008530 DinB superfamily; Region: DinB_2; pfam12867 1114958008531 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114958008532 MOSC domain; Region: MOSC; pfam03473 1114958008533 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114958008534 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1114958008535 active site 1114958008536 NAD binding site [chemical binding]; other site 1114958008537 metal binding site [ion binding]; metal-binding site 1114958008538 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1114958008539 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114958008540 tetramerization interface [polypeptide binding]; other site 1114958008541 NAD(P) binding site [chemical binding]; other site 1114958008542 catalytic residues [active] 1114958008543 Predicted transcriptional regulators [Transcription]; Region: COG1510 1114958008544 Helix-turn-helix domains; Region: HTH; cl00088 1114958008545 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114958008546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958008547 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114958008548 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114958008549 SH3-like domain; Region: SH3_8; pfam13457 1114958008550 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1114958008551 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1114958008552 heme-binding site [chemical binding]; other site 1114958008553 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1114958008554 FAD binding pocket [chemical binding]; other site 1114958008555 FAD binding motif [chemical binding]; other site 1114958008556 phosphate binding motif [ion binding]; other site 1114958008557 beta-alpha-beta structure motif; other site 1114958008558 NAD binding pocket [chemical binding]; other site 1114958008559 Heme binding pocket [chemical binding]; other site 1114958008560 Cupin domain; Region: Cupin_2; cl09118 1114958008561 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958008562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958008563 binding surface 1114958008564 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958008565 TPR motif; other site 1114958008566 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958008567 amidase catalytic site [active] 1114958008568 Zn binding residues [ion binding]; other site 1114958008569 substrate binding site [chemical binding]; other site 1114958008570 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958008571 Holin family; Region: Phage_holin_4; cl01989 1114958008572 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1114958008573 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1114958008574 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1114958008575 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114958008576 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1114958008577 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114958008578 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1114958008579 Phage tail protein; Region: Sipho_tail; pfam05709 1114958008580 Phage-related minor tail protein [Function unknown]; Region: COG5280 1114958008581 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1114958008582 MAEBL; Provisional; Region: PTZ00121 1114958008583 Phage-related tail protein [Function unknown]; Region: COG5283 1114958008584 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1114958008585 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958008586 catalytic residue [active] 1114958008587 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1114958008588 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1114958008589 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1114958008590 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1114958008591 oligomerization interface [polypeptide binding]; other site 1114958008592 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1114958008593 Phage capsid family; Region: Phage_capsid; pfam05065 1114958008594 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1114958008595 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1114958008596 oligomer interface [polypeptide binding]; other site 1114958008597 active site residues [active] 1114958008598 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1114958008599 Phage portal protein; Region: Phage_portal; pfam04860 1114958008600 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1114958008601 Phage Terminase; Region: Terminase_1; pfam03354 1114958008602 Phage terminase, small subunit; Region: Terminase_4; cl01525 1114958008603 HNH endonuclease; Region: HNH_3; pfam13392 1114958008604 Predicted transcriptional regulator [Transcription]; Region: COG1395 1114958008605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958008606 non-specific DNA binding site [nucleotide binding]; other site 1114958008607 salt bridge; other site 1114958008608 sequence-specific DNA binding site [nucleotide binding]; other site 1114958008609 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1114958008610 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1114958008611 Int/Topo IB signature motif; other site 1114958008612 Bacitracin resistance protein BacA; Region: BacA; cl00858 1114958008613 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958008614 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114958008615 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114958008616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958008617 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114958008618 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1114958008619 proposed catalytic triad [active] 1114958008620 conserved cys residue [active] 1114958008621 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114958008622 Cache domain; Region: Cache_1; pfam02743 1114958008623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958008624 dimerization interface [polypeptide binding]; other site 1114958008625 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958008626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958008627 dimer interface [polypeptide binding]; other site 1114958008628 putative CheW interface [polypeptide binding]; other site 1114958008629 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114958008630 Cache domain; Region: Cache_1; pfam02743 1114958008631 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958008632 dimerization interface [polypeptide binding]; other site 1114958008633 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958008634 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958008635 dimer interface [polypeptide binding]; other site 1114958008636 putative CheW interface [polypeptide binding]; other site 1114958008637 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114958008638 Cache domain; Region: Cache_1; pfam02743 1114958008639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958008640 dimerization interface [polypeptide binding]; other site 1114958008641 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958008642 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958008643 dimer interface [polypeptide binding]; other site 1114958008644 putative CheW interface [polypeptide binding]; other site 1114958008645 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958008646 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114958008647 Cache domain; Region: Cache_1; pfam02743 1114958008648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958008649 dimerization interface [polypeptide binding]; other site 1114958008650 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958008651 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958008652 dimer interface [polypeptide binding]; other site 1114958008653 putative CheW interface [polypeptide binding]; other site 1114958008654 transglutaminase; Provisional; Region: tgl; PRK03187 1114958008655 Nitronate monooxygenase; Region: NMO; pfam03060 1114958008656 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1114958008657 FMN binding site [chemical binding]; other site 1114958008658 substrate binding site [chemical binding]; other site 1114958008659 putative catalytic residue [active] 1114958008660 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1114958008661 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1114958008662 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1114958008663 Ca binding site [ion binding]; other site 1114958008664 active site 1114958008665 catalytic site [active] 1114958008666 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114958008667 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114958008668 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114958008669 Transporter associated domain; Region: CorC_HlyC; cl08393 1114958008670 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 1114958008671 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1114958008672 Ion channel; Region: Ion_trans_2; cl11596 1114958008673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958008674 YugN-like family; Region: YugN; pfam08868 1114958008675 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1114958008676 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1114958008677 active site 1114958008678 dimer interface [polypeptide binding]; other site 1114958008679 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1114958008680 dimer interface [polypeptide binding]; other site 1114958008681 active site 1114958008682 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958008683 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958008684 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114958008685 catalytic triad [active] 1114958008686 dimer interface [polypeptide binding]; other site 1114958008687 conserved cis-peptide bond; other site 1114958008688 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1114958008689 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1114958008690 dimer interface [polypeptide binding]; other site 1114958008691 active site 1114958008692 metal binding site [ion binding]; metal-binding site 1114958008693 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1114958008694 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1114958008695 dimer interface [polypeptide binding]; other site 1114958008696 active site 1114958008697 metal binding site [ion binding]; metal-binding site 1114958008698 Domain of unknown function (DUF378); Region: DUF378; cl00943 1114958008699 general stress protein 13; Validated; Region: PRK08059 1114958008700 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1114958008701 RNA binding site [nucleotide binding]; other site 1114958008702 hypothetical protein; Validated; Region: PRK07682 1114958008703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958008704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958008705 homodimer interface [polypeptide binding]; other site 1114958008706 catalytic residue [active] 1114958008707 Helix-turn-helix domains; Region: HTH; cl00088 1114958008708 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958008709 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958008710 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1114958008711 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1114958008712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958008713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958008714 homodimer interface [polypeptide binding]; other site 1114958008715 catalytic residue [active] 1114958008716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958008717 dimer interface [polypeptide binding]; other site 1114958008718 phosphorylation site [posttranslational modification] 1114958008719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958008720 ATP binding site [chemical binding]; other site 1114958008721 Mg2+ binding site [ion binding]; other site 1114958008722 G-X-G motif; other site 1114958008723 Kinase associated protein B; Region: KapB; pfam08810 1114958008724 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1114958008725 active site 1114958008726 catalytic site [active] 1114958008727 substrate binding site [chemical binding]; other site 1114958008728 drug efflux system protein MdtG; Provisional; Region: PRK09874 1114958008729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008730 putative substrate translocation pore; other site 1114958008731 Transglycosylase; Region: Transgly; cl07896 1114958008732 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1114958008733 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958008734 Protein of unknown function, DUF393; Region: DUF393; cl01136 1114958008735 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1114958008736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958008737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958008738 ATP binding site [chemical binding]; other site 1114958008739 Mg2+ binding site [ion binding]; other site 1114958008740 G-X-G motif; other site 1114958008741 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1114958008742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958008743 active site 1114958008744 phosphorylation site [posttranslational modification] 1114958008745 intermolecular recognition site; other site 1114958008746 dimerization interface [polypeptide binding]; other site 1114958008747 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1114958008748 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1114958008749 ligand binding site [chemical binding]; other site 1114958008750 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1114958008751 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1114958008752 Walker A/P-loop; other site 1114958008753 ATP binding site [chemical binding]; other site 1114958008754 Q-loop/lid; other site 1114958008755 ABC transporter signature motif; other site 1114958008756 Walker B; other site 1114958008757 D-loop; other site 1114958008758 H-loop/switch region; other site 1114958008759 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1114958008760 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114958008761 TM-ABC transporter signature motif; other site 1114958008762 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114958008763 TM-ABC transporter signature motif; other site 1114958008764 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1114958008765 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1114958008766 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1114958008767 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1114958008768 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1114958008769 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1114958008770 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1114958008771 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1114958008772 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1114958008773 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1114958008774 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114958008775 CoenzymeA binding site [chemical binding]; other site 1114958008776 subunit interaction site [polypeptide binding]; other site 1114958008777 PHB binding site; other site 1114958008778 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958008779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958008780 active site 1114958008781 phosphorylation site [posttranslational modification] 1114958008782 intermolecular recognition site; other site 1114958008783 dimerization interface [polypeptide binding]; other site 1114958008784 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958008785 Histidine kinase; Region: HisKA_3; pfam07730 1114958008786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114958008787 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1114958008788 substrate binding pocket [chemical binding]; other site 1114958008789 substrate-Mg2+ binding site; other site 1114958008790 aspartate-rich region 1; other site 1114958008791 aspartate-rich region 2; other site 1114958008792 DegQ (SacQ) family; Region: DegQ; pfam08181 1114958008793 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1114958008794 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1114958008795 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1114958008796 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1114958008797 active site 1114958008798 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958008799 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1114958008800 catalytic triad [active] 1114958008801 conserved cis-peptide bond; other site 1114958008802 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 1114958008803 YueH-like protein; Region: YueH; pfam14166 1114958008804 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958008805 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958008806 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1114958008807 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1114958008808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1114958008809 short chain dehydrogenase; Provisional; Region: PRK06924 1114958008810 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1114958008811 NADP binding site [chemical binding]; other site 1114958008812 homodimer interface [polypeptide binding]; other site 1114958008813 active site 1114958008814 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 1114958008815 Predicted membrane protein [Function unknown]; Region: COG1511 1114958008816 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114958008817 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1114958008818 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1114958008819 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958008820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958008821 Domain of unknown function DUF87; Region: DUF87; pfam01935 1114958008822 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1114958008823 Ubiquitin-like proteins; Region: UBQ; cl00155 1114958008824 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1114958008825 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1114958008826 CodY GAF-like domain; Region: CodY; pfam06018 1114958008827 Helix-turn-helix domains; Region: HTH; cl00088 1114958008828 alanine dehydrogenase; Region: alaDH; TIGR00518 1114958008829 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1114958008830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958008831 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1114958008832 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1114958008833 MbtH-like protein; Region: MbtH; cl01279 1114958008834 peptide synthase; Provisional; Region: PRK12316 1114958008835 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008836 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008837 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958008838 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1114958008839 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958008840 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008841 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008842 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958008843 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1114958008844 hydrophobic substrate binding pocket; other site 1114958008845 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958008846 active site 1114958008847 conserved cis-peptide bond; other site 1114958008848 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958008849 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1114958008850 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008851 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958008852 isochorismate synthase DhbC; Validated; Region: PRK06923 1114958008853 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114958008854 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958008855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958008856 NAD(P) binding site [chemical binding]; other site 1114958008857 active site 1114958008858 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958008859 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1114958008860 Moco binding site; other site 1114958008861 metal coordination site [ion binding]; other site 1114958008862 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1114958008863 Predicted permease [General function prediction only]; Region: COG2056 1114958008864 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1114958008865 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1114958008866 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1114958008867 interface (dimer of trimers) [polypeptide binding]; other site 1114958008868 Substrate-binding/catalytic site; other site 1114958008869 Zn-binding sites [ion binding]; other site 1114958008870 Divergent PAP2 family; Region: DUF212; cl00855 1114958008871 3D domain; Region: 3D; cl01439 1114958008872 Putative membrane protein; Region: YuiB; pfam14068 1114958008873 chaperone protein DnaJ; Provisional; Region: PRK14290 1114958008874 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114958008875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958008876 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1114958008877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958008878 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1114958008879 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1114958008880 active site 1114958008881 Integral membrane protein DUF95; Region: DUF95; cl00572 1114958008882 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114958008883 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1114958008884 Walker A/P-loop; other site 1114958008885 ATP binding site [chemical binding]; other site 1114958008886 Q-loop/lid; other site 1114958008887 ABC transporter signature motif; other site 1114958008888 Walker B; other site 1114958008889 D-loop; other site 1114958008890 H-loop/switch region; other site 1114958008891 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1114958008892 DNA binding residues [nucleotide binding] 1114958008893 putative dimer interface [polypeptide binding]; other site 1114958008894 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1114958008895 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1114958008896 putative NAD(P) binding site [chemical binding]; other site 1114958008897 active site 1114958008898 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1114958008899 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1114958008900 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114958008901 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114958008902 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1114958008903 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1114958008904 Nucleoside recognition; Region: Gate; cl00486 1114958008905 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1114958008906 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1114958008907 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114958008908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958008909 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 1114958008910 NifU-like domain; Region: NifU; cl00484 1114958008911 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1114958008912 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114958008913 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1114958008914 structural tetrad; other site 1114958008915 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958008916 homoserine kinase; Provisional; Region: PRK01212 1114958008917 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1114958008918 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1114958008919 threonine synthase; Reviewed; Region: PRK06721 1114958008920 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1114958008921 homodimer interface [polypeptide binding]; other site 1114958008922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958008923 catalytic residue [active] 1114958008924 homoserine dehydrogenase; Provisional; Region: PRK06349 1114958008925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958008926 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114958008927 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1114958008928 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958008929 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1114958008930 tetramer interfaces [polypeptide binding]; other site 1114958008931 binuclear metal-binding site [ion binding]; other site 1114958008932 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1114958008933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958008934 active site 1114958008935 motif I; other site 1114958008936 motif II; other site 1114958008937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958008938 Protein of unknown function DUF86; Region: DUF86; cl01031 1114958008939 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 1114958008940 lipoyl synthase; Provisional; Region: PRK05481 1114958008941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958008942 FeS/SAM binding site; other site 1114958008943 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114958008944 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1114958008945 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1114958008946 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1114958008947 active site 1114958008948 metal binding site [ion binding]; metal-binding site 1114958008949 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1114958008950 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1114958008951 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114958008952 Protein of unknown function DUF72; Region: DUF72; cl00777 1114958008953 allantoinase; Provisional; Region: PRK06189 1114958008954 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1114958008955 active site 1114958008956 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1114958008957 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1114958008958 Helix-turn-helix domains; Region: HTH; cl00088 1114958008959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008960 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958008961 putative substrate translocation pore; other site 1114958008962 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1114958008963 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958008964 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958008965 catalytic residue [active] 1114958008966 allantoate amidohydrolase; Reviewed; Region: PRK09290 1114958008967 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1114958008968 active site 1114958008969 metal binding site [ion binding]; metal-binding site 1114958008970 dimer interface [polypeptide binding]; other site 1114958008971 Endonuclease I; Region: Endonuclease_1; cl01003 1114958008972 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114958008973 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1114958008974 Walker A/P-loop; other site 1114958008975 ATP binding site [chemical binding]; other site 1114958008976 Q-loop/lid; other site 1114958008977 ABC transporter signature motif; other site 1114958008978 Walker B; other site 1114958008979 D-loop; other site 1114958008980 H-loop/switch region; other site 1114958008981 TOBE domain; Region: TOBE_2; cl01440 1114958008982 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1114958008983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958008984 DNA-binding site [nucleotide binding]; DNA binding site 1114958008985 UTRA domain; Region: UTRA; cl01230 1114958008986 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1114958008987 substrate binding site [chemical binding]; other site 1114958008988 ATP binding site [chemical binding]; other site 1114958008989 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114958008990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008991 dimer interface [polypeptide binding]; other site 1114958008992 conserved gate region; other site 1114958008993 putative PBP binding loops; other site 1114958008994 ABC-ATPase subunit interface; other site 1114958008995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008996 dimer interface [polypeptide binding]; other site 1114958008997 conserved gate region; other site 1114958008998 putative PBP binding loops; other site 1114958008999 ABC-ATPase subunit interface; other site 1114958009000 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114958009001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114958009002 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1114958009003 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1114958009004 putative active site [active] 1114958009005 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1114958009006 dimer interface [polypeptide binding]; other site 1114958009007 active site 1114958009008 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1114958009009 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114958009010 GIY-YIG motif/motif A; other site 1114958009011 active site 1114958009012 catalytic site [active] 1114958009013 putative DNA binding site [nucleotide binding]; other site 1114958009014 metal binding site [ion binding]; metal-binding site 1114958009015 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114958009016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958009017 S-adenosylmethionine binding site [chemical binding]; other site 1114958009018 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1114958009019 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1114958009020 chitosan binding site [chemical binding]; other site 1114958009021 catalytic residues [active] 1114958009022 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1114958009023 FeS assembly protein SufB; Region: sufB; TIGR01980 1114958009024 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1114958009025 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1114958009026 trimerization site [polypeptide binding]; other site 1114958009027 active site 1114958009028 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114958009029 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1114958009030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958009031 catalytic residue [active] 1114958009032 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1114958009033 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1114958009034 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1114958009035 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 1114958009036 Walker A/P-loop; other site 1114958009037 ATP binding site [chemical binding]; other site 1114958009038 Q-loop/lid; other site 1114958009039 ABC transporter signature motif; other site 1114958009040 Walker B; other site 1114958009041 D-loop; other site 1114958009042 H-loop/switch region; other site 1114958009043 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114958009044 NMT1-like family; Region: NMT1_2; cl15260 1114958009045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009046 ABC-ATPase subunit interface; other site 1114958009047 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1114958009048 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1114958009049 Walker A/P-loop; other site 1114958009050 ATP binding site [chemical binding]; other site 1114958009051 Q-loop/lid; other site 1114958009052 ABC transporter signature motif; other site 1114958009053 Walker B; other site 1114958009054 D-loop; other site 1114958009055 H-loop/switch region; other site 1114958009056 NIL domain; Region: NIL; cl09633 1114958009057 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958009058 catalytic residues [active] 1114958009059 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1114958009060 putative active site [active] 1114958009061 putative metal binding site [ion binding]; other site 1114958009062 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1114958009063 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114958009064 lipoyl attachment site [posttranslational modification]; other site 1114958009065 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1114958009066 ArsC family; Region: ArsC; pfam03960 1114958009067 putative ArsC-like catalytic residues; other site 1114958009068 putative TRX-like catalytic residues [active] 1114958009069 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114958009070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114958009071 active site 1114958009072 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1114958009073 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114958009074 dimer interface [polypeptide binding]; other site 1114958009075 active site 1114958009076 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1114958009077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009078 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114958009079 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114958009080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958009081 substrate binding site [chemical binding]; other site 1114958009082 oxyanion hole (OAH) forming residues; other site 1114958009083 trimer interface [polypeptide binding]; other site 1114958009084 YuzL-like protein; Region: YuzL; pfam14115 1114958009085 Proline dehydrogenase; Region: Pro_dh; cl03282 1114958009086 Coat F domain; Region: Coat_F; cl15836 1114958009087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958009088 Helix-turn-helix domains; Region: HTH; cl00088 1114958009089 Helix-turn-helix domains; Region: HTH; cl00088 1114958009090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009091 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958009092 putative substrate translocation pore; other site 1114958009093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958009095 Helix-turn-helix domains; Region: HTH; cl00088 1114958009096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958009097 dimerization interface [polypeptide binding]; other site 1114958009098 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1114958009099 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1114958009100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009101 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114958009102 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1114958009103 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114958009104 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114958009105 Walker A/P-loop; other site 1114958009106 ATP binding site [chemical binding]; other site 1114958009107 Q-loop/lid; other site 1114958009108 ABC transporter signature motif; other site 1114958009109 Walker B; other site 1114958009110 D-loop; other site 1114958009111 H-loop/switch region; other site 1114958009112 YusW-like protein; Region: YusW; pfam14039 1114958009113 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1114958009114 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1114958009115 active site 1114958009116 Zn binding site [ion binding]; other site 1114958009117 short chain dehydrogenase; Provisional; Region: PRK06914 1114958009118 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1114958009119 NADP binding site [chemical binding]; other site 1114958009120 active site 1114958009121 steroid binding site; other site 1114958009122 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1114958009123 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1114958009124 dimerization interface [polypeptide binding]; other site 1114958009125 DPS ferroxidase diiron center [ion binding]; other site 1114958009126 ion pore; other site 1114958009127 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1114958009128 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1114958009129 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958009130 protein binding site [polypeptide binding]; other site 1114958009131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958009132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009133 active site 1114958009134 phosphorylation site [posttranslational modification] 1114958009135 intermolecular recognition site; other site 1114958009136 dimerization interface [polypeptide binding]; other site 1114958009137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958009138 DNA binding site [nucleotide binding] 1114958009139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958009140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958009141 dimerization interface [polypeptide binding]; other site 1114958009142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958009143 dimer interface [polypeptide binding]; other site 1114958009144 phosphorylation site [posttranslational modification] 1114958009145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009146 ATP binding site [chemical binding]; other site 1114958009147 Mg2+ binding site [ion binding]; other site 1114958009148 G-X-G motif; other site 1114958009149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958009150 Helix-turn-helix domains; Region: HTH; cl00088 1114958009151 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1114958009152 Class II fumarases; Region: Fumarase_classII; cd01362 1114958009153 active site 1114958009154 tetramer interface [polypeptide binding]; other site 1114958009155 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1114958009156 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958009157 Spore germination protein; Region: Spore_permease; cl15802 1114958009158 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1114958009159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958009160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009161 active site 1114958009162 phosphorylation site [posttranslational modification] 1114958009163 intermolecular recognition site; other site 1114958009164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958009165 DNA binding residues [nucleotide binding] 1114958009166 dimerization interface [polypeptide binding]; other site 1114958009167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958009168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958009169 dimerization interface [polypeptide binding]; other site 1114958009170 Histidine kinase; Region: HisKA_3; pfam07730 1114958009171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009172 ATP binding site [chemical binding]; other site 1114958009173 Mg2+ binding site [ion binding]; other site 1114958009174 G-X-G motif; other site 1114958009175 Predicted membrane protein [Function unknown]; Region: COG4758 1114958009176 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1114958009177 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1114958009178 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1114958009179 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1114958009180 PspA/IM30 family; Region: PspA_IM30; pfam04012 1114958009181 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1114958009182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009183 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958009184 putative substrate translocation pore; other site 1114958009185 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1114958009186 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114958009187 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114958009188 Walker A/P-loop; other site 1114958009189 ATP binding site [chemical binding]; other site 1114958009190 Q-loop/lid; other site 1114958009191 ABC transporter signature motif; other site 1114958009192 Walker B; other site 1114958009193 D-loop; other site 1114958009194 H-loop/switch region; other site 1114958009195 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1114958009196 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1114958009197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958009198 ABC-ATPase subunit interface; other site 1114958009199 dimer interface [polypeptide binding]; other site 1114958009200 putative PBP binding regions; other site 1114958009201 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958009202 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1114958009203 putative binding site residues; other site 1114958009204 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958009205 classical (c) SDRs; Region: SDR_c; cd05233 1114958009206 NAD(P) binding site [chemical binding]; other site 1114958009207 active site 1114958009208 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114958009209 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114958009210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958009211 dimer interface [polypeptide binding]; other site 1114958009212 phosphorylation site [posttranslational modification] 1114958009213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009214 ATP binding site [chemical binding]; other site 1114958009215 Mg2+ binding site [ion binding]; other site 1114958009216 G-X-G motif; other site 1114958009217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958009218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009219 active site 1114958009220 phosphorylation site [posttranslational modification] 1114958009221 intermolecular recognition site; other site 1114958009222 dimerization interface [polypeptide binding]; other site 1114958009223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958009224 DNA binding site [nucleotide binding] 1114958009225 hypothetical protein; Provisional; Region: PRK14082 1114958009226 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1114958009227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958009228 DNA binding residues [nucleotide binding] 1114958009229 YvrJ protein family; Region: YvrJ; pfam12841 1114958009230 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1114958009231 Cupin domain; Region: Cupin_2; cl09118 1114958009232 Cupin domain; Region: Cupin_2; cl09118 1114958009233 Regulatory protein YrvL; Region: YrvL; pfam14184 1114958009234 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114958009235 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114958009236 Walker A/P-loop; other site 1114958009237 ATP binding site [chemical binding]; other site 1114958009238 Q-loop/lid; other site 1114958009239 ABC transporter signature motif; other site 1114958009240 Walker B; other site 1114958009241 D-loop; other site 1114958009242 H-loop/switch region; other site 1114958009243 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1114958009244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958009245 ABC-ATPase subunit interface; other site 1114958009246 dimer interface [polypeptide binding]; other site 1114958009247 putative PBP binding regions; other site 1114958009248 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958009249 ABC-ATPase subunit interface; other site 1114958009250 dimer interface [polypeptide binding]; other site 1114958009251 putative PBP binding regions; other site 1114958009252 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958009253 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1114958009254 putative ligand binding residues [chemical binding]; other site 1114958009255 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1114958009256 putrescine transporter; Provisional; Region: potE; PRK10655 1114958009257 Spore germination protein; Region: Spore_permease; cl15802 1114958009258 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 1114958009259 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1114958009260 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1114958009261 Sulfatase; Region: Sulfatase; cl10460 1114958009262 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1114958009263 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114958009264 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114958009265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114958009266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009267 dimer interface [polypeptide binding]; other site 1114958009268 conserved gate region; other site 1114958009269 putative PBP binding loops; other site 1114958009270 ABC-ATPase subunit interface; other site 1114958009271 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958009272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009273 active site 1114958009274 phosphorylation site [posttranslational modification] 1114958009275 intermolecular recognition site; other site 1114958009276 dimerization interface [polypeptide binding]; other site 1114958009277 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958009278 DNA binding residues [nucleotide binding] 1114958009279 dimerization interface [polypeptide binding]; other site 1114958009280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958009281 Histidine kinase; Region: HisKA_3; pfam07730 1114958009282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114958009283 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958009284 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1114958009285 Walker A/P-loop; other site 1114958009286 ATP binding site [chemical binding]; other site 1114958009287 Q-loop/lid; other site 1114958009288 ABC transporter signature motif; other site 1114958009289 Walker B; other site 1114958009290 D-loop; other site 1114958009291 H-loop/switch region; other site 1114958009292 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114958009293 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958009294 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114958009295 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958009296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958009297 active site 1114958009298 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958009299 catalytic tetrad [active] 1114958009300 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1114958009301 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 1114958009302 sulfite reductase subunit beta; Provisional; Region: PRK13504 1114958009303 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114958009304 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114958009305 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1114958009306 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958009307 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1114958009308 FAD binding pocket [chemical binding]; other site 1114958009309 FAD binding motif [chemical binding]; other site 1114958009310 catalytic residues [active] 1114958009311 NAD binding pocket [chemical binding]; other site 1114958009312 phosphate binding motif [ion binding]; other site 1114958009313 beta-alpha-beta structure motif; other site 1114958009314 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1114958009315 Family description; Region: UvrD_C_2; cl15862 1114958009316 Predicted membrane protein [Function unknown]; Region: COG2860 1114958009317 UPF0126 domain; Region: UPF0126; pfam03458 1114958009318 UPF0126 domain; Region: UPF0126; pfam03458 1114958009319 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1114958009320 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1114958009321 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114958009322 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114958009323 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114958009324 metal-binding site [ion binding] 1114958009325 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114958009326 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958009327 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114958009328 metal-binding site [ion binding] 1114958009329 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114958009330 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114958009331 metal-binding site [ion binding] 1114958009332 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114958009333 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958009334 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114958009335 metal-binding site [ion binding] 1114958009336 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1114958009337 putative homodimer interface [polypeptide binding]; other site 1114958009338 putative homotetramer interface [polypeptide binding]; other site 1114958009339 putative allosteric switch controlling residues; other site 1114958009340 putative metal binding site [ion binding]; other site 1114958009341 putative homodimer-homodimer interface [polypeptide binding]; other site 1114958009342 putative oxidoreductase; Provisional; Region: PRK11579 1114958009343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009344 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114958009345 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958009346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958009347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009348 putative substrate translocation pore; other site 1114958009349 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114958009350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958009351 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1114958009352 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1114958009353 active site 1114958009354 non-prolyl cis peptide bond; other site 1114958009355 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1114958009356 catalytic residues [active] 1114958009357 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1114958009358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958009359 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958009360 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1114958009361 Walker A/P-loop; other site 1114958009362 ATP binding site [chemical binding]; other site 1114958009363 Q-loop/lid; other site 1114958009364 ABC transporter signature motif; other site 1114958009365 Walker B; other site 1114958009366 D-loop; other site 1114958009367 H-loop/switch region; other site 1114958009368 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114958009369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009370 dimer interface [polypeptide binding]; other site 1114958009371 conserved gate region; other site 1114958009372 putative PBP binding loops; other site 1114958009373 ABC-ATPase subunit interface; other site 1114958009374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009375 dimer interface [polypeptide binding]; other site 1114958009376 conserved gate region; other site 1114958009377 putative PBP binding loops; other site 1114958009378 ABC-ATPase subunit interface; other site 1114958009379 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114958009380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958009381 substrate binding pocket [chemical binding]; other site 1114958009382 membrane-bound complex binding site; other site 1114958009383 hinge residues; other site 1114958009384 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114958009385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958009386 substrate binding pocket [chemical binding]; other site 1114958009387 membrane-bound complex binding site; other site 1114958009388 hinge residues; other site 1114958009389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958009390 Coenzyme A binding pocket [chemical binding]; other site 1114958009391 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958009392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958009393 Helix-turn-helix domains; Region: HTH; cl00088 1114958009394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958009395 dimerization interface [polypeptide binding]; other site 1114958009396 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958009397 classical (c) SDRs; Region: SDR_c; cd05233 1114958009398 NAD(P) binding site [chemical binding]; other site 1114958009399 active site 1114958009400 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1114958009401 RNAase interaction site [polypeptide binding]; other site 1114958009402 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1114958009403 SmpB-tmRNA interface; other site 1114958009404 ribonuclease R; Region: RNase_R; TIGR02063 1114958009405 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114958009406 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114958009407 RNB domain; Region: RNB; pfam00773 1114958009408 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 1114958009409 RNA binding site [nucleotide binding]; other site 1114958009410 Esterase/lipase [General function prediction only]; Region: COG1647 1114958009411 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958009412 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1114958009413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009414 salt bridge; other site 1114958009415 non-specific DNA binding site [nucleotide binding]; other site 1114958009416 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009417 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958009418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009419 non-specific DNA binding site [nucleotide binding]; other site 1114958009420 salt bridge; other site 1114958009421 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009423 non-specific DNA binding site [nucleotide binding]; other site 1114958009424 salt bridge; other site 1114958009425 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009426 Helix-turn-helix domains; Region: HTH; cl00088 1114958009427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958009428 dimer interface [polypeptide binding]; other site 1114958009429 phosphorylation site [posttranslational modification] 1114958009430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009431 ATP binding site [chemical binding]; other site 1114958009432 Mg2+ binding site [ion binding]; other site 1114958009433 G-X-G motif; other site 1114958009434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958009435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009436 active site 1114958009437 phosphorylation site [posttranslational modification] 1114958009438 intermolecular recognition site; other site 1114958009439 dimerization interface [polypeptide binding]; other site 1114958009440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958009441 DNA binding site [nucleotide binding] 1114958009442 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958009443 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958009444 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1114958009445 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1114958009446 Walker A/P-loop; other site 1114958009447 ATP binding site [chemical binding]; other site 1114958009448 Q-loop/lid; other site 1114958009449 ABC transporter signature motif; other site 1114958009450 Walker B; other site 1114958009451 D-loop; other site 1114958009452 H-loop/switch region; other site 1114958009453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009454 dimer interface [polypeptide binding]; other site 1114958009455 conserved gate region; other site 1114958009456 putative PBP binding loops; other site 1114958009457 ABC-ATPase subunit interface; other site 1114958009458 NMT1-like family; Region: NMT1_2; cl15260 1114958009459 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114958009460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009461 dimer interface [polypeptide binding]; other site 1114958009462 conserved gate region; other site 1114958009463 putative PBP binding loops; other site 1114958009464 ABC-ATPase subunit interface; other site 1114958009465 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1114958009466 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1114958009467 Walker A/P-loop; other site 1114958009468 ATP binding site [chemical binding]; other site 1114958009469 Q-loop/lid; other site 1114958009470 ABC transporter signature motif; other site 1114958009471 Walker B; other site 1114958009472 D-loop; other site 1114958009473 H-loop/switch region; other site 1114958009474 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1114958009475 Predicted transcriptional regulators [Transcription]; Region: COG1510 1114958009476 Helix-turn-helix domains; Region: HTH; cl00088 1114958009477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009478 dimer interface [polypeptide binding]; other site 1114958009479 conserved gate region; other site 1114958009480 putative PBP binding loops; other site 1114958009481 ABC-ATPase subunit interface; other site 1114958009482 NMT1-like family; Region: NMT1_2; cl15260 1114958009483 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114958009484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009485 dimer interface [polypeptide binding]; other site 1114958009486 conserved gate region; other site 1114958009487 putative PBP binding loops; other site 1114958009488 ABC-ATPase subunit interface; other site 1114958009489 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1114958009490 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1114958009491 Walker A/P-loop; other site 1114958009492 ATP binding site [chemical binding]; other site 1114958009493 Q-loop/lid; other site 1114958009494 ABC transporter signature motif; other site 1114958009495 Walker B; other site 1114958009496 D-loop; other site 1114958009497 H-loop/switch region; other site 1114958009498 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1114958009499 Predicted transcriptional regulators [Transcription]; Region: COG1510 1114958009500 Helix-turn-helix domains; Region: HTH; cl00088 1114958009501 MarC family integral membrane protein; Region: MarC; cl00919 1114958009502 Predicted membrane protein [Function unknown]; Region: COG4640 1114958009503 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1114958009504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958009505 Coenzyme A binding pocket [chemical binding]; other site 1114958009506 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958009507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009508 putative substrate translocation pore; other site 1114958009509 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114958009510 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1114958009511 WbqC-like protein family; Region: WbqC; pfam08889 1114958009512 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958009513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958009514 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1114958009515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958009516 catalytic residue [active] 1114958009517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009518 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1114958009519 NAD(P) binding site [chemical binding]; other site 1114958009520 active site 1114958009521 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1114958009522 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114958009523 inhibitor-cofactor binding pocket; inhibition site 1114958009524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958009525 catalytic residue [active] 1114958009526 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1114958009527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009528 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114958009529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009530 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1114958009531 PA/protease domain interface [polypeptide binding]; other site 1114958009532 putative integrin binding motif; other site 1114958009533 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1114958009534 metal binding site [ion binding]; metal-binding site 1114958009535 enolase; Provisional; Region: eno; PRK00077 1114958009536 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1114958009537 dimer interface [polypeptide binding]; other site 1114958009538 metal binding site [ion binding]; metal-binding site 1114958009539 substrate binding pocket [chemical binding]; other site 1114958009540 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1114958009541 Sulfatase; Region: Sulfatase; cl10460 1114958009542 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1114958009543 substrate binding site [chemical binding]; other site 1114958009544 dimer interface [polypeptide binding]; other site 1114958009545 catalytic triad [active] 1114958009546 Phosphoglycerate kinase; Region: PGK; pfam00162 1114958009547 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1114958009548 substrate binding site [chemical binding]; other site 1114958009549 hinge regions; other site 1114958009550 ADP binding site [chemical binding]; other site 1114958009551 catalytic site [active] 1114958009552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009553 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1114958009554 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1114958009555 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114958009556 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114958009557 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114958009558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958009560 DNA-binding site [nucleotide binding]; DNA binding site 1114958009561 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958009562 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1114958009563 putative dimerization interface [polypeptide binding]; other site 1114958009564 putative ligand binding site [chemical binding]; other site 1114958009565 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958009566 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1114958009567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958009568 Helix-turn-helix domains; Region: HTH; cl00088 1114958009569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958009570 dimerization interface [polypeptide binding]; other site 1114958009571 EamA-like transporter family; Region: EamA; cl01037 1114958009572 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114958009573 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114958009574 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958009575 active site 1114958009576 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958009577 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958009578 DNA binding site [nucleotide binding] 1114958009579 domain linker motif; other site 1114958009580 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1114958009581 putative ligand binding site [chemical binding]; other site 1114958009582 putative dimerization interface [polypeptide binding]; other site 1114958009583 Predicted membrane protein [Function unknown]; Region: COG2364 1114958009584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958009585 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958009586 active site 1114958009587 motif I; other site 1114958009588 motif II; other site 1114958009589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958009590 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114958009591 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114958009592 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114958009593 putative active site [active] 1114958009594 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1114958009595 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1114958009596 N- and C-terminal domain interface [polypeptide binding]; other site 1114958009597 putative active site [active] 1114958009598 catalytic site [active] 1114958009599 metal binding site [ion binding]; metal-binding site 1114958009600 carbohydrate binding site [chemical binding]; other site 1114958009601 ATP binding site [chemical binding]; other site 1114958009602 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1114958009603 GntP family permease; Region: GntP_permease; pfam02447 1114958009604 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1114958009605 iron-sulfur cluster-binding protein; Region: TIGR00273 1114958009606 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1114958009607 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1114958009608 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1114958009609 Cysteine-rich domain; Region: CCG; pfam02754 1114958009610 Cysteine-rich domain; Region: CCG; pfam02754 1114958009611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958009612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958009613 homodimer interface [polypeptide binding]; other site 1114958009614 catalytic residue [active] 1114958009615 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114958009616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958009617 DNA-binding site [nucleotide binding]; DNA binding site 1114958009618 FCD domain; Region: FCD; cl11656 1114958009619 glycolate transporter; Provisional; Region: PRK09695 1114958009620 L-lactate permease; Region: Lactate_perm; cl00701 1114958009621 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1114958009622 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1114958009623 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1114958009624 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1114958009625 YvfG protein; Region: YvfG; pfam09628 1114958009626 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1114958009627 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1114958009628 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114958009629 inhibitor-cofactor binding pocket; inhibition site 1114958009630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958009631 catalytic residue [active] 1114958009632 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1114958009633 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1114958009634 putative trimer interface [polypeptide binding]; other site 1114958009635 putative CoA binding site [chemical binding]; other site 1114958009636 Bacterial sugar transferase; Region: Bac_transf; cl00939 1114958009637 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1114958009638 MatE; Region: MatE; cl10513 1114958009639 putative glycosyl transferase; Provisional; Region: PRK10073 1114958009640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958009641 active site 1114958009642 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1114958009643 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958009644 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958009645 active site 1114958009646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958009647 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1114958009648 putative ADP-binding pocket [chemical binding]; other site 1114958009649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114958009650 active site 1114958009651 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1114958009652 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958009653 putative ADP-binding pocket [chemical binding]; other site 1114958009654 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1114958009655 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1114958009656 NAD(P) binding site [chemical binding]; other site 1114958009657 homodimer interface [polypeptide binding]; other site 1114958009658 substrate binding site [chemical binding]; other site 1114958009659 active site 1114958009660 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1114958009661 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958009662 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1114958009663 Chain length determinant protein; Region: Wzz; cl15801 1114958009664 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958009665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009666 non-specific DNA binding site [nucleotide binding]; other site 1114958009667 salt bridge; other site 1114958009668 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009669 Anti-repressor SinI; Region: SinI; pfam08671 1114958009670 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114958009671 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1114958009672 substrate binding pocket [chemical binding]; other site 1114958009673 catalytic triad [active] 1114958009674 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1114958009675 folate binding site [chemical binding]; other site 1114958009676 NADP+ binding site [chemical binding]; other site 1114958009677 Predicted membrane protein [Function unknown]; Region: COG2364 1114958009678 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958009679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958009680 Coenzyme A binding pocket [chemical binding]; other site 1114958009681 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1114958009682 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 1114958009683 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1114958009684 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1114958009685 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1114958009686 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1114958009687 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1114958009688 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1114958009689 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1114958009690 substrate binding [chemical binding]; other site 1114958009691 active site 1114958009692 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1114958009693 galactoside permease; Reviewed; Region: lacY; PRK09528 1114958009694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009695 putative substrate translocation pore; other site 1114958009696 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958009697 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958009698 DNA binding site [nucleotide binding] 1114958009699 domain linker motif; other site 1114958009700 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1114958009701 dimerization interface [polypeptide binding]; other site 1114958009702 ligand binding site [chemical binding]; other site 1114958009703 sodium binding site [ion binding]; other site 1114958009704 Clp protease; Region: CLP_protease; pfam00574 1114958009705 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1114958009706 oligomer interface [polypeptide binding]; other site 1114958009707 active site residues [active] 1114958009708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958009709 Helix-turn-helix domains; Region: HTH; cl00088 1114958009710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958009711 dimerization interface [polypeptide binding]; other site 1114958009712 PrpF protein; Region: PrpF; pfam04303 1114958009713 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1114958009714 benzoate transport; Region: 2A0115; TIGR00895 1114958009715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009716 putative substrate translocation pore; other site 1114958009717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009718 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114958009719 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1114958009720 putative transporter; Provisional; Region: PRK11660 1114958009721 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114958009722 Sulfate transporter family; Region: Sulfate_transp; cl15842 1114958009723 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114958009724 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1114958009725 active site clefts [active] 1114958009726 zinc binding site [ion binding]; other site 1114958009727 dimer interface [polypeptide binding]; other site 1114958009728 glyoxylate reductase; Reviewed; Region: PRK13243 1114958009729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009730 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1114958009731 active site 1114958009732 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1114958009733 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114958009734 dimerization domain swap beta strand [polypeptide binding]; other site 1114958009735 regulatory protein interface [polypeptide binding]; other site 1114958009736 active site 1114958009737 regulatory phosphorylation site [posttranslational modification]; other site 1114958009738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1114958009739 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1114958009740 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1114958009741 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1114958009742 phosphate binding site [ion binding]; other site 1114958009743 putative substrate binding pocket [chemical binding]; other site 1114958009744 dimer interface [polypeptide binding]; other site 1114958009745 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1114958009746 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1114958009747 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1114958009748 putative active site [active] 1114958009749 nucleotide binding site [chemical binding]; other site 1114958009750 nudix motif; other site 1114958009751 putative metal binding site [ion binding]; other site 1114958009752 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1114958009753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958009755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1114958009756 B-cell receptor-associated protein 31-like; Region: Bap31; cl02219 1114958009757 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958009758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958009759 binding surface 1114958009760 TPR motif; other site 1114958009761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958009762 TPR motif; other site 1114958009763 binding surface 1114958009764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958009765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958009766 dimer interface [polypeptide binding]; other site 1114958009767 phosphorylation site [posttranslational modification] 1114958009768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009769 ATP binding site [chemical binding]; other site 1114958009770 Mg2+ binding site [ion binding]; other site 1114958009771 G-X-G motif; other site 1114958009772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958009773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009774 active site 1114958009775 phosphorylation site [posttranslational modification] 1114958009776 intermolecular recognition site; other site 1114958009777 dimerization interface [polypeptide binding]; other site 1114958009778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958009779 DNA binding site [nucleotide binding] 1114958009780 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958009781 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958009782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958009783 Walker A/P-loop; other site 1114958009784 ATP binding site [chemical binding]; other site 1114958009785 Q-loop/lid; other site 1114958009786 ABC transporter signature motif; other site 1114958009787 Walker B; other site 1114958009788 D-loop; other site 1114958009789 H-loop/switch region; other site 1114958009790 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1114958009791 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1114958009792 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1114958009793 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1114958009794 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1114958009795 substrate binding site [chemical binding]; other site 1114958009796 glutamase interaction surface [polypeptide binding]; other site 1114958009797 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1114958009798 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1114958009799 catalytic residues [active] 1114958009800 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1114958009801 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1114958009802 putative active site [active] 1114958009803 oxyanion strand; other site 1114958009804 catalytic triad [active] 1114958009805 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 1114958009806 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1114958009807 putative active site pocket [active] 1114958009808 4-fold oligomerization interface [polypeptide binding]; other site 1114958009809 metal binding residues [ion binding]; metal-binding site 1114958009810 3-fold/trimer interface [polypeptide binding]; other site 1114958009811 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1114958009812 histidinol dehydrogenase; Region: hisD; TIGR00069 1114958009813 NAD binding site [chemical binding]; other site 1114958009814 dimerization interface [polypeptide binding]; other site 1114958009815 product binding site; other site 1114958009816 substrate binding site [chemical binding]; other site 1114958009817 zinc binding site [ion binding]; other site 1114958009818 catalytic residues [active] 1114958009819 ATP phosphoribosyltransferase; Region: HisG; cl15266 1114958009820 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1114958009821 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1114958009822 dimer interface [polypeptide binding]; other site 1114958009823 motif 1; other site 1114958009824 active site 1114958009825 motif 2; other site 1114958009826 motif 3; other site 1114958009827 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1114958009828 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 1114958009829 putative active site [active] 1114958009830 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1114958009831 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1114958009832 trimer interface [polypeptide binding]; other site 1114958009833 active site 1114958009834 substrate binding site [chemical binding]; other site 1114958009835 CoA binding site [chemical binding]; other site 1114958009836 pyrophosphatase PpaX; Provisional; Region: PRK13288 1114958009837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958009838 active site 1114958009839 motif I; other site 1114958009840 motif II; other site 1114958009841 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1114958009842 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1114958009843 DRTGG domain; Region: DRTGG; cl12147 1114958009844 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1114958009845 Hpr binding site; other site 1114958009846 active site 1114958009847 homohexamer subunit interaction site [polypeptide binding]; other site 1114958009848 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1114958009849 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1114958009850 active site 1114958009851 dimer interface [polypeptide binding]; other site 1114958009852 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1114958009853 active site 1114958009854 trimer interface [polypeptide binding]; other site 1114958009855 allosteric site; other site 1114958009856 active site lid [active] 1114958009857 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1114958009858 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114958009859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958009860 DNA-binding site [nucleotide binding]; DNA binding site 1114958009861 UTRA domain; Region: UTRA; cl01230 1114958009862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958009863 Helix-turn-helix domains; Region: HTH; cl00088 1114958009864 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1114958009865 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958009866 putative active site [active] 1114958009867 putative metal binding site [ion binding]; other site 1114958009868 Membrane protein of unknown function; Region: DUF360; cl00850 1114958009869 PspC domain; Region: PspC; cl00864 1114958009870 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1114958009871 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1114958009872 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1114958009873 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1114958009874 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1114958009875 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1114958009876 excinuclease ABC subunit B; Provisional; Region: PRK05298 1114958009877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958009878 ATP binding site [chemical binding]; other site 1114958009879 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958009880 nucleotide binding region [chemical binding]; other site 1114958009881 ATP-binding site [chemical binding]; other site 1114958009882 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1114958009883 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1114958009884 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1114958009885 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114958009886 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1114958009887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958009888 Helix-turn-helix domains; Region: HTH; cl00088 1114958009889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009890 putative substrate translocation pore; other site 1114958009891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958009892 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1114958009893 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958009894 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958009895 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958009896 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958009897 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958009898 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1114958009899 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958009900 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114958009901 C-terminal peptidase (prc); Region: prc; TIGR00225 1114958009902 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114958009903 protein binding site [polypeptide binding]; other site 1114958009904 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1114958009905 Catalytic dyad [active] 1114958009906 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1114958009907 Right handed beta helix region; Region: Beta_helix; pfam13229 1114958009908 Right handed beta helix region; Region: Beta_helix; pfam13229 1114958009909 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1114958009910 FtsX-like permease family; Region: FtsX; cl15850 1114958009911 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1114958009912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958009913 Walker A/P-loop; other site 1114958009914 ATP binding site [chemical binding]; other site 1114958009915 Q-loop/lid; other site 1114958009916 ABC transporter signature motif; other site 1114958009917 Walker B; other site 1114958009918 D-loop; other site 1114958009919 H-loop/switch region; other site 1114958009920 Cytochrome c; Region: Cytochrom_C; cl11414 1114958009921 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958009922 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958009923 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958009924 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1114958009925 peptide chain release factor 2; Provisional; Region: PRK06746 1114958009926 RF-1 domain; Region: RF-1; cl02875 1114958009927 RF-1 domain; Region: RF-1; cl02875 1114958009928 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1114958009929 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1114958009930 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958009931 SEC-C motif; Region: SEC-C; pfam02810 1114958009932 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1114958009933 30S subunit binding site; other site 1114958009934 Flagellar protein FliT; Region: FliT; cl05125 1114958009935 Flagellar protein FliS; Region: FliS; cl00654 1114958009936 flagellar capping protein; Validated; Region: fliD; PRK07737 1114958009937 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1114958009938 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1114958009939 flagellin; Provisional; Region: PRK12804 1114958009940 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114958009941 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1114958009942 Global regulator protein family; Region: CsrA; cl00670 1114958009943 FliW protein; Region: FliW; cl00740 1114958009944 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1114958009945 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114958009946 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1114958009947 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 1114958009948 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114958009949 FlgN protein; Region: FlgN; cl09176 1114958009950 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1114958009951 flagellar operon protein TIGR03826; Region: YvyF 1114958009952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958009953 active site 1114958009954 Late competence development protein ComFB; Region: ComFB; pfam10719 1114958009955 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1114958009956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958009957 ATP binding site [chemical binding]; other site 1114958009958 putative Mg++ binding site [ion binding]; other site 1114958009959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958009960 nucleotide binding region [chemical binding]; other site 1114958009961 ATP-binding site [chemical binding]; other site 1114958009962 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1114958009963 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958009964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009965 active site 1114958009966 phosphorylation site [posttranslational modification] 1114958009967 intermolecular recognition site; other site 1114958009968 dimerization interface [polypeptide binding]; other site 1114958009969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958009970 DNA binding residues [nucleotide binding] 1114958009971 dimerization interface [polypeptide binding]; other site 1114958009972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958009973 Histidine kinase; Region: HisKA_3; pfam07730 1114958009974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009975 ATP binding site [chemical binding]; other site 1114958009976 Mg2+ binding site [ion binding]; other site 1114958009977 G-X-G motif; other site 1114958009978 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1114958009979 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1114958009980 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1114958009981 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1114958009982 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1114958009983 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1114958009984 Mg++ binding site [ion binding]; other site 1114958009985 putative catalytic motif [active] 1114958009986 substrate binding site [chemical binding]; other site 1114958009987 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1114958009988 putative homodimer interface [polypeptide binding]; other site 1114958009989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958009990 active site 1114958009991 O-Antigen ligase; Region: Wzy_C; cl04850 1114958009992 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114958009993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009994 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114958009995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009996 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1114958009997 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1114958009998 colanic acid exporter; Provisional; Region: PRK10459 1114958009999 MatE; Region: MatE; cl10513 1114958010000 Bacterial sugar transferase; Region: Bac_transf; cl00939 1114958010001 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010002 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010003 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010004 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958010005 active site 1114958010006 metal binding site [ion binding]; metal-binding site 1114958010007 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010008 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010009 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010010 Stage II sporulation protein; Region: SpoIID; pfam08486 1114958010011 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1114958010012 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1114958010013 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1114958010014 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114958010015 active site 1114958010016 homodimer interface [polypeptide binding]; other site 1114958010017 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1114958010018 active site 1114958010019 tetramer interface; other site 1114958010020 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1114958010021 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1114958010022 Walker A/P-loop; other site 1114958010023 ATP binding site [chemical binding]; other site 1114958010024 Q-loop/lid; other site 1114958010025 ABC transporter signature motif; other site 1114958010026 Walker B; other site 1114958010027 D-loop; other site 1114958010028 H-loop/switch region; other site 1114958010029 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958010030 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1114958010031 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958010032 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958010033 active site 1114958010034 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1114958010035 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1114958010036 active site 1114958010037 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1114958010038 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1114958010039 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1114958010040 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958010041 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1114958010042 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1114958010043 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1114958010044 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958010045 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1114958010046 Spore germination protein; Region: Spore_permease; cl15802 1114958010047 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1114958010048 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114958010049 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1114958010050 Probable Catalytic site; other site 1114958010051 metal-binding site 1114958010052 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1114958010053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958010054 S-adenosylmethionine binding site [chemical binding]; other site 1114958010055 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114958010056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010057 putative substrate translocation pore; other site 1114958010058 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1114958010059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010060 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958010061 active site 1114958010062 motif I; other site 1114958010063 motif II; other site 1114958010064 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1114958010065 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1114958010066 Septum formation initiator; Region: DivIC; cl11433 1114958010067 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958010068 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958010069 NlpC/P60 family; Region: NLPC_P60; cl11438 1114958010070 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1114958010071 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1114958010072 putative active site [active] 1114958010073 putative metal binding site [ion binding]; other site 1114958010074 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 1114958010075 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1114958010076 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958010077 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958010078 Spore germination protein; Region: Spore_permease; cl15802 1114958010079 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1114958010080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958010081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958010082 DNA binding site [nucleotide binding] 1114958010083 domain linker motif; other site 1114958010084 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114958010085 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958010086 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1114958010087 substrate binding site [chemical binding]; other site 1114958010088 dimer interface [polypeptide binding]; other site 1114958010089 ATP binding site [chemical binding]; other site 1114958010090 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1114958010091 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114958010092 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1114958010093 Walker A/P-loop; other site 1114958010094 ATP binding site [chemical binding]; other site 1114958010095 Q-loop/lid; other site 1114958010096 ABC transporter signature motif; other site 1114958010097 Walker B; other site 1114958010098 D-loop; other site 1114958010099 H-loop/switch region; other site 1114958010100 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1114958010101 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114958010102 TM-ABC transporter signature motif; other site 1114958010103 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1114958010104 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1114958010105 ligand binding site [chemical binding]; other site 1114958010106 dimerization interface [polypeptide binding]; other site 1114958010107 Bacterial SH3 domain; Region: SH3_3; cl02551 1114958010108 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958010109 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 1114958010110 acetolactate synthase; Reviewed; Region: PRK08617 1114958010111 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114958010112 PYR/PP interface [polypeptide binding]; other site 1114958010113 dimer interface [polypeptide binding]; other site 1114958010114 TPP binding site [chemical binding]; other site 1114958010115 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114958010116 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1114958010117 TPP-binding site [chemical binding]; other site 1114958010118 dimer interface [polypeptide binding]; other site 1114958010119 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1114958010120 Helix-turn-helix domains; Region: HTH; cl00088 1114958010121 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1114958010122 putative dimerization interface [polypeptide binding]; other site 1114958010123 putative substrate binding pocket [chemical binding]; other site 1114958010124 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1114958010125 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1114958010126 transmembrane helices; other site 1114958010127 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1114958010128 Flavin Reductases; Region: FlaRed; cl00801 1114958010129 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1114958010130 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1114958010131 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1114958010132 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114958010133 Helix-turn-helix domains; Region: HTH; cl00088 1114958010134 Chromate transporter; Region: Chromate_transp; pfam02417 1114958010135 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1114958010136 Chromate transporter; Region: Chromate_transp; pfam02417 1114958010137 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958010138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958010139 Helix-turn-helix domains; Region: HTH; cl00088 1114958010140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958010141 dimerization interface [polypeptide binding]; other site 1114958010142 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1114958010143 Active_site [active] 1114958010144 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1114958010145 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958010146 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958010147 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 1114958010148 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958010149 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1114958010150 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1114958010151 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114958010152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958010153 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114958010154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958010155 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1114958010156 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1114958010157 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1114958010158 Nucleotide binding site [chemical binding]; other site 1114958010159 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1114958010160 Chain length determinant protein; Region: Wzz; cl15801 1114958010161 SWIM zinc finger; Region: SWIM; cl15408 1114958010162 SNF2 Helicase protein; Region: DUF3670; pfam12419 1114958010163 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114958010164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958010165 ATP binding site [chemical binding]; other site 1114958010166 putative Mg++ binding site [ion binding]; other site 1114958010167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958010168 nucleotide binding region [chemical binding]; other site 1114958010169 ATP-binding site [chemical binding]; other site 1114958010170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010171 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958010172 active site 1114958010173 motif I; other site 1114958010174 motif II; other site 1114958010175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010176 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958010177 Helix-turn-helix domains; Region: HTH; cl00088 1114958010178 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114958010179 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114958010180 dimer interface [polypeptide binding]; other site 1114958010181 ssDNA binding site [nucleotide binding]; other site 1114958010182 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958010183 YwpF-like protein; Region: YwpF; pfam14183 1114958010184 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1114958010185 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1114958010186 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1114958010187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958010188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958010189 binding surface 1114958010190 TPR motif; other site 1114958010191 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1114958010192 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 1114958010193 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114958010194 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1114958010195 Flagella basal body rod protein; Region: Flg_bb_rod; cl16924 1114958010196 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114958010197 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1114958010198 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1114958010199 ATP binding site [chemical binding]; other site 1114958010200 profilin binding site; other site 1114958010201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958010202 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958010203 Helix-turn-helix domains; Region: HTH; cl00088 1114958010204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010205 putative substrate translocation pore; other site 1114958010206 Sodium:solute symporter family; Region: SSF; cl00456 1114958010207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958010209 putative substrate translocation pore; other site 1114958010210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010211 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958010212 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1114958010213 catalytic triad [active] 1114958010214 conserved cis-peptide bond; other site 1114958010215 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1114958010216 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1114958010217 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1114958010218 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1114958010219 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1114958010220 active site 1114958010221 VanZ like family; Region: VanZ; cl01971 1114958010222 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114958010223 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 1114958010224 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114958010225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958010226 Coenzyme A binding pocket [chemical binding]; other site 1114958010227 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1114958010228 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1114958010229 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114958010230 putative active site [active] 1114958010231 catalytic site [active] 1114958010232 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1114958010233 putative active site [active] 1114958010234 catalytic site [active] 1114958010235 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1114958010236 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958010237 Helix-turn-helix domains; Region: HTH; cl00088 1114958010238 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1114958010239 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1114958010240 subunit interactions [polypeptide binding]; other site 1114958010241 active site 1114958010242 flap region; other site 1114958010243 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1114958010244 gamma-beta subunit interface [polypeptide binding]; other site 1114958010245 alpha-beta subunit interface [polypeptide binding]; other site 1114958010246 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1114958010247 alpha-gamma subunit interface [polypeptide binding]; other site 1114958010248 beta-gamma subunit interface [polypeptide binding]; other site 1114958010249 CsbD-like; Region: CsbD; cl15799 1114958010250 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958010251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958010252 TPR repeat; Region: TPR_11; pfam13414 1114958010253 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1114958010254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958010255 FeS/SAM binding site; other site 1114958010256 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1114958010257 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1114958010258 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1114958010259 metal ion-dependent adhesion site (MIDAS); other site 1114958010260 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1114958010261 metal ion-dependent adhesion site (MIDAS); other site 1114958010262 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1114958010263 Stage II sporulation protein; Region: SpoIID; pfam08486 1114958010264 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1114958010265 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1114958010266 hinge; other site 1114958010267 active site 1114958010268 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1114958010269 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1114958010270 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1114958010271 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1114958010272 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 1114958010273 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1114958010274 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1114958010275 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1114958010276 alpha subunit interaction interface [polypeptide binding]; other site 1114958010277 Walker A motif; other site 1114958010278 ATP binding site [chemical binding]; other site 1114958010279 Walker B motif; other site 1114958010280 inhibitor binding site; inhibition site 1114958010281 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114958010282 ATP synthase; Region: ATP-synt; cl00365 1114958010283 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1114958010284 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1114958010285 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1114958010286 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1114958010287 beta subunit interaction interface [polypeptide binding]; other site 1114958010288 Walker A motif; other site 1114958010289 ATP binding site [chemical binding]; other site 1114958010290 Walker B motif; other site 1114958010291 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114958010292 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1114958010293 Plant ATP synthase F0; Region: YMF19; cl07975 1114958010294 Plant ATP synthase F0; Region: YMF19; cl07975 1114958010295 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1114958010296 ATP synthase A chain; Region: ATP-synt_A; cl00413 1114958010297 ATP synthase I chain; Region: ATP_synt_I; cl09170 1114958010298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958010299 active site 1114958010300 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1114958010301 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114958010302 dimer interface [polypeptide binding]; other site 1114958010303 active site 1114958010304 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114958010305 folate binding site [chemical binding]; other site 1114958010306 Protein of unknown function (DUF436); Region: DUF436; cl01860 1114958010307 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1114958010308 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1114958010309 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1114958010310 active site 1114958010311 Domain of unknown function DUF; Region: DUF204; pfam02659 1114958010312 Domain of unknown function DUF; Region: DUF204; pfam02659 1114958010313 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1114958010314 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1114958010315 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958010316 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 1114958010317 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1114958010318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958010319 S-adenosylmethionine binding site [chemical binding]; other site 1114958010320 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1114958010321 RF-1 domain; Region: RF-1; cl02875 1114958010322 RF-1 domain; Region: RF-1; cl02875 1114958010323 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1114958010324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958010325 putative metal binding site [ion binding]; other site 1114958010326 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1114958010327 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1114958010328 DNA binding residues [nucleotide binding] 1114958010329 Membrane transport protein; Region: Mem_trans; cl09117 1114958010330 malate dehydrogenase; Provisional; Region: PRK13529 1114958010331 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114958010332 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1114958010333 NAD(P) binding site [chemical binding]; other site 1114958010334 thymidine kinase; Provisional; Region: PRK04296 1114958010335 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1114958010336 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1114958010337 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1114958010338 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1114958010339 RNA binding site [nucleotide binding]; other site 1114958010340 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1114958010341 multimer interface [polypeptide binding]; other site 1114958010342 Walker A motif; other site 1114958010343 ATP binding site [chemical binding]; other site 1114958010344 Walker B motif; other site 1114958010345 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1114958010346 putative active site [active] 1114958010347 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1114958010348 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1114958010349 hinge; other site 1114958010350 active site 1114958010351 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1114958010352 active site 1114958010353 intersubunit interactions; other site 1114958010354 catalytic residue [active] 1114958010355 hypothetical protein; Provisional; Region: PRK08185 1114958010356 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1114958010357 intersubunit interface [polypeptide binding]; other site 1114958010358 active site 1114958010359 zinc binding site [ion binding]; other site 1114958010360 Na+ binding site [ion binding]; other site 1114958010361 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958010362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958010363 active site 1114958010364 phosphorylation site [posttranslational modification] 1114958010365 intermolecular recognition site; other site 1114958010366 dimerization interface [polypeptide binding]; other site 1114958010367 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1114958010368 CTP synthetase; Validated; Region: pyrG; PRK05380 1114958010369 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1114958010370 Catalytic site [active] 1114958010371 active site 1114958010372 UTP binding site [chemical binding]; other site 1114958010373 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1114958010374 active site 1114958010375 putative oxyanion hole; other site 1114958010376 catalytic triad [active] 1114958010377 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 1114958010378 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1114958010379 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114958010380 Cysteine-rich domain; Region: CCG; pfam02754 1114958010381 Cysteine-rich domain; Region: CCG; pfam02754 1114958010382 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114958010383 putative active site [active] 1114958010384 catalytic site [active] 1114958010385 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1114958010386 PLD-like domain; Region: PLDc_2; pfam13091 1114958010387 putative active site [active] 1114958010388 catalytic site [active] 1114958010389 UV-endonuclease UvdE; Region: UvdE; cl10036 1114958010390 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958010391 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958010392 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1114958010393 Walker A/P-loop; other site 1114958010394 ATP binding site [chemical binding]; other site 1114958010395 Q-loop/lid; other site 1114958010396 ABC transporter signature motif; other site 1114958010397 Walker B; other site 1114958010398 D-loop; other site 1114958010399 H-loop/switch region; other site 1114958010400 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1114958010401 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1114958010402 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114958010403 putative active site [active] 1114958010404 catalytic site [active] 1114958010405 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1114958010406 putative active site [active] 1114958010407 catalytic site [active] 1114958010408 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958010409 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958010410 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1114958010411 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1114958010412 nitrate reductase, beta subunit; Region: narH; TIGR01660 1114958010413 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1114958010414 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1114958010415 [4Fe-4S] binding site [ion binding]; other site 1114958010416 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114958010417 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114958010418 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114958010419 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114958010420 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1114958010421 molybdopterin cofactor binding site; other site 1114958010422 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114958010423 ligand binding site [chemical binding]; other site 1114958010424 flexible hinge region; other site 1114958010425 YwiC-like protein; Region: YwiC; pfam14256 1114958010426 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114958010427 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1114958010428 ligand binding site [chemical binding]; other site 1114958010429 flexible hinge region; other site 1114958010430 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114958010431 putative switch regulator; other site 1114958010432 non-specific DNA interactions [nucleotide binding]; other site 1114958010433 DNA binding site [nucleotide binding] 1114958010434 sequence specific DNA binding site [nucleotide binding]; other site 1114958010435 putative cAMP binding site [chemical binding]; other site 1114958010436 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1114958010437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010438 putative substrate translocation pore; other site 1114958010439 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1114958010440 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 1114958010441 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1114958010442 active site 1114958010443 HIGH motif; other site 1114958010444 KMSK motif region; other site 1114958010445 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1114958010446 tRNA binding surface [nucleotide binding]; other site 1114958010447 anticodon binding site; other site 1114958010448 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1114958010449 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1114958010450 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1114958010451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958010452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958010453 non-specific DNA binding site [nucleotide binding]; other site 1114958010454 salt bridge; other site 1114958010455 sequence-specific DNA binding site [nucleotide binding]; other site 1114958010456 Integral membrane protein DUF95; Region: DUF95; cl00572 1114958010457 Arginase family; Region: Arginase; cl00306 1114958010458 spermidine synthase; Provisional; Region: PRK00811 1114958010459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958010460 Transglycosylase; Region: Transgly; cl07896 1114958010461 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1114958010462 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1114958010463 YwhD family; Region: YwhD; pfam08741 1114958010464 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1114958010465 active site 1114958010466 putative substrate binding region [chemical binding]; other site 1114958010467 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1114958010468 active site 1 [active] 1114958010469 dimer interface [polypeptide binding]; other site 1114958010470 hexamer interface [polypeptide binding]; other site 1114958010471 active site 2 [active] 1114958010472 Helix-turn-helix domains; Region: HTH; cl00088 1114958010473 Helix-turn-helix domains; Region: HTH; cl00088 1114958010474 amino acid transporter; Region: 2A0306; TIGR00909 1114958010475 Spore germination protein; Region: Spore_permease; cl15802 1114958010476 Spore germination protein; Region: Spore_permease; cl15802 1114958010477 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1114958010478 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1114958010479 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958010480 Zn2+ binding site [ion binding]; other site 1114958010481 Mg2+ binding site [ion binding]; other site 1114958010482 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1114958010483 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1114958010484 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1114958010485 Helix-turn-helix domains; Region: HTH; cl00088 1114958010486 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 1114958010487 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958010488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958010489 Walker A/P-loop; other site 1114958010490 ATP binding site [chemical binding]; other site 1114958010491 Q-loop/lid; other site 1114958010492 ABC transporter signature motif; other site 1114958010493 Walker B; other site 1114958010494 D-loop; other site 1114958010495 H-loop/switch region; other site 1114958010496 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1114958010497 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1114958010498 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1114958010499 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1114958010500 Helix-turn-helix domains; Region: HTH; cl00088 1114958010501 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1114958010502 putative dimerization interface [polypeptide binding]; other site 1114958010503 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1114958010504 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1114958010505 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1114958010506 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1114958010507 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958010508 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1114958010509 putative NAD(P) binding site [chemical binding]; other site 1114958010510 putative active site [active] 1114958010511 transaminase; Reviewed; Region: PRK08068 1114958010512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958010513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958010514 homodimer interface [polypeptide binding]; other site 1114958010515 catalytic residue [active] 1114958010516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010517 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958010518 putative substrate translocation pore; other site 1114958010519 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1114958010520 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958010521 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958010522 classical (c) SDRs; Region: SDR_c; cd05233 1114958010523 NAD(P) binding site [chemical binding]; other site 1114958010524 active site 1114958010525 Cupin domain; Region: Cupin_2; cl09118 1114958010526 Cupin domain; Region: Cupin_2; cl09118 1114958010527 Prephenate dehydratase; Region: PDT; pfam00800 1114958010528 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958010529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010530 putative substrate translocation pore; other site 1114958010531 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1114958010532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010533 putative substrate translocation pore; other site 1114958010534 S-methylmethionine transporter; Provisional; Region: PRK11387 1114958010535 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 1114958010536 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1114958010537 putative metal binding site [ion binding]; other site 1114958010538 putative dimer interface [polypeptide binding]; other site 1114958010539 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1114958010540 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1114958010541 Glutamate binding site [chemical binding]; other site 1114958010542 homodimer interface [polypeptide binding]; other site 1114958010543 NAD binding site [chemical binding]; other site 1114958010544 catalytic residues [active] 1114958010545 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1114958010546 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114958010547 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1114958010548 NAD(P) binding site [chemical binding]; other site 1114958010549 Cupin domain; Region: Cupin_2; cl09118 1114958010550 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1114958010551 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1114958010552 NADP binding site [chemical binding]; other site 1114958010553 active site 1114958010554 putative substrate binding site [chemical binding]; other site 1114958010555 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1114958010556 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1114958010557 NAD binding site [chemical binding]; other site 1114958010558 substrate binding site [chemical binding]; other site 1114958010559 homodimer interface [polypeptide binding]; other site 1114958010560 active site 1114958010561 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1114958010562 substrate binding site; other site 1114958010563 tetramer interface; other site 1114958010564 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1114958010565 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114958010566 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1114958010567 ligand binding site; other site 1114958010568 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1114958010569 NeuB family; Region: NeuB; cl00496 1114958010570 SAF domain; Region: SAF; cl00555 1114958010571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114958010572 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958010573 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1114958010574 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114958010575 inhibitor-cofactor binding pocket; inhibition site 1114958010576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958010577 catalytic residue [active] 1114958010578 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1114958010579 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114958010580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958010581 active site 1114958010582 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 1114958010583 Protein of unknown function (DUF423); Region: DUF423; cl01008 1114958010584 Permease family; Region: Xan_ur_permease; pfam00860 1114958010585 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1114958010586 ligand binding site [chemical binding]; other site 1114958010587 active site 1114958010588 UGI interface [polypeptide binding]; other site 1114958010589 catalytic site [active] 1114958010590 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958010591 active site 1114958010592 Helix-turn-helix domains; Region: HTH; cl00088 1114958010593 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114958010594 dimer interface [polypeptide binding]; other site 1114958010595 substrate binding site [chemical binding]; other site 1114958010596 ATP binding site [chemical binding]; other site 1114958010597 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1114958010598 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1114958010599 substrate binding [chemical binding]; other site 1114958010600 active site 1114958010601 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1114958010602 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1114958010603 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958010604 active site turn [active] 1114958010605 phosphorylation site [posttranslational modification] 1114958010606 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958010607 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1114958010608 CAT RNA binding domain; Region: CAT_RBD; cl03904 1114958010609 PRD domain; Region: PRD; cl15445 1114958010610 PRD domain; Region: PRD; cl15445 1114958010611 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1114958010612 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1114958010613 putative active site [active] 1114958010614 catalytic triad [active] 1114958010615 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1114958010616 PA/protease domain interface [polypeptide binding]; other site 1114958010617 putative integrin binding motif; other site 1114958010618 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1114958010619 FlgD Ig-like domain; Region: FlgD_ig; cl15790 1114958010620 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958010621 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1114958010622 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1114958010623 dimer interface [polypeptide binding]; other site 1114958010624 FMN binding site [chemical binding]; other site 1114958010625 NADPH bind site [chemical binding]; other site 1114958010626 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1114958010627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114958010628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958010629 Coenzyme A binding pocket [chemical binding]; other site 1114958010630 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1114958010631 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1114958010632 Subunit I/III interface [polypeptide binding]; other site 1114958010633 Subunit III/IV interface [polypeptide binding]; other site 1114958010634 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114958010635 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1114958010636 D-pathway; other site 1114958010637 Putative ubiquinol binding site [chemical binding]; other site 1114958010638 Low-spin heme (heme b) binding site [chemical binding]; other site 1114958010639 Putative water exit pathway; other site 1114958010640 Binuclear center (heme o3/CuB) [ion binding]; other site 1114958010641 K-pathway; other site 1114958010642 Putative proton exit pathway; other site 1114958010643 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1114958010644 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1114958010645 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1114958010646 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1114958010647 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1114958010648 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1114958010649 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1114958010650 GtrA-like protein; Region: GtrA; cl00971 1114958010651 Helix-turn-helix domains; Region: HTH; cl00088 1114958010652 Anti-repressor SinI; Region: SinI; pfam08671 1114958010653 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1114958010654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958010655 S-adenosylmethionine binding site [chemical binding]; other site 1114958010656 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1114958010657 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1114958010658 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1114958010659 catalytic residues [active] 1114958010660 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1114958010661 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1114958010662 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1114958010663 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114958010664 thiamine phosphate binding site [chemical binding]; other site 1114958010665 active site 1114958010666 pyrophosphate binding site [ion binding]; other site 1114958010667 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1114958010668 substrate binding site [chemical binding]; other site 1114958010669 multimerization interface [polypeptide binding]; other site 1114958010670 ATP binding site [chemical binding]; other site 1114958010671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958010672 Helix-turn-helix domains; Region: HTH; cl00088 1114958010673 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1114958010674 putative dimerization interface [polypeptide binding]; other site 1114958010675 LrgA family; Region: LrgA; cl00608 1114958010676 LrgB-like family; Region: LrgB; cl00596 1114958010677 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 1114958010678 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1114958010679 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114958010680 DNA binding residues [nucleotide binding] 1114958010681 dimer interface [polypeptide binding]; other site 1114958010682 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1114958010683 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1114958010684 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1114958010685 putative RNA binding site [nucleotide binding]; other site 1114958010686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958010687 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958010688 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114958010689 active site 1114958010690 metal binding site [ion binding]; metal-binding site 1114958010691 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1114958010692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958010693 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1114958010694 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1114958010695 active site 1114958010696 catalytic residues [active] 1114958010697 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114958010698 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1114958010699 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1114958010700 Ligand binding site; other site 1114958010701 metal-binding site 1114958010702 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114958010703 synthetase active site [active] 1114958010704 NTP binding site [chemical binding]; other site 1114958010705 metal binding site [ion binding]; metal-binding site 1114958010706 UbiA prenyltransferase family; Region: UbiA; cl00337 1114958010707 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1114958010708 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1114958010709 AMP-binding enzyme; Region: AMP-binding; cl15778 1114958010710 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1114958010711 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958010712 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1114958010713 DltD N-terminal region; Region: DltD_N; pfam04915 1114958010714 DltD central region; Region: DltD_M; pfam04918 1114958010715 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1114958010716 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1114958010717 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1114958010718 homodimer interface [polypeptide binding]; other site 1114958010719 substrate-cofactor binding pocket; other site 1114958010720 catalytic residue [active] 1114958010721 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1114958010722 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1114958010723 NAD binding site [chemical binding]; other site 1114958010724 sugar binding site [chemical binding]; other site 1114958010725 divalent metal binding site [ion binding]; other site 1114958010726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958010727 dimer interface [polypeptide binding]; other site 1114958010728 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1114958010729 methionine cluster; other site 1114958010730 active site 1114958010731 phosphorylation site [posttranslational modification] 1114958010732 metal binding site [ion binding]; metal-binding site 1114958010733 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1114958010734 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958010735 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1114958010736 active site 1114958010737 P-loop; other site 1114958010738 phosphorylation site [posttranslational modification] 1114958010739 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114958010740 Helix-turn-helix domains; Region: HTH; cl00088 1114958010741 Helix-turn-helix domains; Region: HTH; cl00088 1114958010742 PRD domain; Region: PRD; cl15445 1114958010743 PRD domain; Region: PRD; cl15445 1114958010744 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1114958010745 active site 1114958010746 P-loop; other site 1114958010747 phosphorylation site [posttranslational modification] 1114958010748 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958010749 active site 1114958010750 phosphorylation site [posttranslational modification] 1114958010751 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1114958010752 active site 1114958010753 DNA binding site [nucleotide binding] 1114958010754 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1114958010755 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958010756 ABC-ATPase subunit interface; other site 1114958010757 dimer interface [polypeptide binding]; other site 1114958010758 putative PBP binding regions; other site 1114958010759 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958010760 ABC-ATPase subunit interface; other site 1114958010761 dimer interface [polypeptide binding]; other site 1114958010762 putative PBP binding regions; other site 1114958010763 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958010764 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114958010765 intersubunit interface [polypeptide binding]; other site 1114958010766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958010767 dimerization interface [polypeptide binding]; other site 1114958010768 putative DNA binding site [nucleotide binding]; other site 1114958010769 putative Zn2+ binding site [ion binding]; other site 1114958010770 arsenical pump membrane protein; Provisional; Region: PRK15445 1114958010771 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1114958010772 transmembrane helices; other site 1114958010773 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1114958010774 active site 1114958010775 P-loop; other site 1114958010776 phosphorylation site [posttranslational modification] 1114958010777 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1114958010778 active site 1114958010779 methionine cluster; other site 1114958010780 phosphorylation site [posttranslational modification] 1114958010781 metal binding site [ion binding]; metal-binding site 1114958010782 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1114958010783 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1114958010784 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1114958010785 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114958010786 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1114958010787 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1114958010788 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1114958010789 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1114958010790 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 1114958010791 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114958010792 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1114958010793 tetramer interface [polypeptide binding]; other site 1114958010794 heme binding pocket [chemical binding]; other site 1114958010795 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1114958010796 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1114958010797 active site 1114958010798 Sodium:solute symporter family; Region: SSF; cl00456 1114958010799 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1114958010800 putative substrate binding site [chemical binding]; other site 1114958010801 putative ATP binding site [chemical binding]; other site 1114958010802 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1114958010803 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958010804 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 1114958010805 Walker A/P-loop; other site 1114958010806 ATP binding site [chemical binding]; other site 1114958010807 Q-loop/lid; other site 1114958010808 ABC transporter signature motif; other site 1114958010809 Walker B; other site 1114958010810 D-loop; other site 1114958010811 H-loop/switch region; other site 1114958010812 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1114958010813 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1114958010814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958010815 ATP binding site [chemical binding]; other site 1114958010816 Q-loop/lid; other site 1114958010817 ABC transporter signature motif; other site 1114958010818 Walker B; other site 1114958010819 D-loop; other site 1114958010820 H-loop/switch region; other site 1114958010821 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1114958010822 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1114958010823 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1114958010824 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1114958010825 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1114958010826 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1114958010827 putative active site [active] 1114958010828 putative metal binding site [ion binding]; other site 1114958010829 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114958010830 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1114958010831 Walker A/P-loop; other site 1114958010832 ATP binding site [chemical binding]; other site 1114958010833 Q-loop/lid; other site 1114958010834 ABC transporter signature motif; other site 1114958010835 Walker B; other site 1114958010836 D-loop; other site 1114958010837 H-loop/switch region; other site 1114958010838 TOBE domain; Region: TOBE_2; cl01440 1114958010839 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1114958010840 Helix-turn-helix domains; Region: HTH; cl00088 1114958010841 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958010842 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958010843 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1114958010844 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1114958010845 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1114958010846 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1114958010847 UDP-glucose 4-epimerase; Region: PLN02240 1114958010848 NAD binding site [chemical binding]; other site 1114958010849 homodimer interface [polypeptide binding]; other site 1114958010850 active site 1114958010851 substrate binding site [chemical binding]; other site 1114958010852 peptidase T; Region: peptidase-T; TIGR01882 1114958010853 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1114958010854 metal binding site [ion binding]; metal-binding site 1114958010855 dimer interface [polypeptide binding]; other site 1114958010856 Scramblase; Region: Scramblase; cl02043 1114958010857 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1114958010858 substrate binding site [chemical binding]; other site 1114958010859 THF binding site; other site 1114958010860 zinc-binding site [ion binding]; other site 1114958010861 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1114958010862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958010863 nucleoside transporter; Region: nupC; TIGR00804 1114958010864 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1114958010865 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1114958010866 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1114958010867 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1114958010868 hydroperoxidase II; Provisional; Region: katE; PRK11249 1114958010869 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1114958010870 tetramer interface [polypeptide binding]; other site 1114958010871 heme binding pocket [chemical binding]; other site 1114958010872 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1114958010873 domain interactions; other site 1114958010874 Citrate transporter; Region: CitMHS; pfam03600 1114958010875 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1114958010876 transmembrane helices; other site 1114958010877 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1114958010878 active site 1114958010879 active site 1114958010880 catalytic residues [active] 1114958010881 PRD domain; Region: PRD; cl15445 1114958010882 PRD domain; Region: PRD; cl15445 1114958010883 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1114958010884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010885 putative substrate translocation pore; other site 1114958010886 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1114958010887 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114958010888 ATP binding site [chemical binding]; other site 1114958010889 Mg++ binding site [ion binding]; other site 1114958010890 motif III; other site 1114958010891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958010892 nucleotide binding region [chemical binding]; other site 1114958010893 DbpA RNA binding domain; Region: DbpA; pfam03880 1114958010894 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1114958010895 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1114958010896 YxiJ-like protein; Region: YxiJ; pfam14176 1114958010897 RHS Repeat; Region: RHS_repeat; cl11982 1114958010898 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114958010899 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1114958010900 RHS Repeat; Region: RHS_repeat; cl11982 1114958010901 RHS Repeat; Region: RHS_repeat; cl11982 1114958010902 RHS Repeat; Region: RHS_repeat; cl11982 1114958010903 RHS Repeat; Region: RHS_repeat; cl11982 1114958010904 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114958010905 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1114958010906 Pectate lyase; Region: Pec_lyase_C; cl01593 1114958010907 EamA-like transporter family; Region: EamA; cl01037 1114958010908 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114958010909 EamA-like transporter family; Region: EamA; cl01037 1114958010910 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114958010911 Ligand Binding Site [chemical binding]; other site 1114958010912 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 1114958010913 PLD-like domain; Region: PLDc_2; pfam13091 1114958010914 putative homodimer interface [polypeptide binding]; other site 1114958010915 putative active site [active] 1114958010916 catalytic site [active] 1114958010917 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114958010918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958010919 ATP binding site [chemical binding]; other site 1114958010920 putative Mg++ binding site [ion binding]; other site 1114958010921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958010922 nucleotide binding region [chemical binding]; other site 1114958010923 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1114958010924 ATP-binding site [chemical binding]; other site 1114958010925 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1114958010926 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1114958010927 active site 1114958010928 8-oxo-dGMP binding site [chemical binding]; other site 1114958010929 nudix motif; other site 1114958010930 metal binding site [ion binding]; metal-binding site 1114958010931 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1114958010932 substrate binding site [chemical binding]; other site 1114958010933 active site 1114958010934 HutP; Region: HutP; cl07944 1114958010935 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114958010936 active sites [active] 1114958010937 tetramer interface [polypeptide binding]; other site 1114958010938 urocanate hydratase; Provisional; Region: PRK05414 1114958010939 imidazolonepropionase; Validated; Region: PRK09356 1114958010940 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1114958010941 active site 1114958010942 Arginase family; Region: Arginase; cl00306 1114958010943 S-methylmethionine transporter; Provisional; Region: PRK11387 1114958010944 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1114958010945 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114958010946 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114958010947 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 1114958010948 nucleoside transporter; Region: nupC; TIGR00804 1114958010949 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1114958010950 Nucleoside recognition; Region: Gate; cl00486 1114958010951 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1114958010952 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1114958010953 intersubunit interface [polypeptide binding]; other site 1114958010954 active site 1114958010955 catalytic residue [active] 1114958010956 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114958010957 Helix-turn-helix domains; Region: HTH; cl00088 1114958010958 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114958010959 sugar phosphate phosphatase; Provisional; Region: PRK10513 1114958010960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010961 active site 1114958010962 motif I; other site 1114958010963 motif II; other site 1114958010964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010965 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1114958010966 SlyX; Region: SlyX; cl01090 1114958010967 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958010968 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1114958010969 putative ligand binding residues [chemical binding]; other site 1114958010970 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1114958010971 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958010972 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1114958010973 Walker A/P-loop; other site 1114958010974 ATP binding site [chemical binding]; other site 1114958010975 Q-loop/lid; other site 1114958010976 ABC transporter signature motif; other site 1114958010977 Walker B; other site 1114958010978 D-loop; other site 1114958010979 H-loop/switch region; other site 1114958010980 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114958010981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114958010982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958010983 ATP binding site [chemical binding]; other site 1114958010984 Mg2+ binding site [ion binding]; other site 1114958010985 G-X-G motif; other site 1114958010986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958010987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958010988 active site 1114958010989 phosphorylation site [posttranslational modification] 1114958010990 intermolecular recognition site; other site 1114958010991 dimerization interface [polypeptide binding]; other site 1114958010992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958010993 DNA binding site [nucleotide binding] 1114958010994 hypothetical protein; Provisional; Region: PRK08185 1114958010995 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1114958010996 intersubunit interface [polypeptide binding]; other site 1114958010997 active site 1114958010998 zinc binding site [ion binding]; other site 1114958010999 Na+ binding site [ion binding]; other site 1114958011000 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114958011001 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114958011002 Metal-binding active site; metal-binding site 1114958011003 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114958011004 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114958011005 DNA interaction; other site 1114958011006 Metal-binding active site; metal-binding site 1114958011007 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114958011008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958011009 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1114958011010 Glucuronate isomerase; Region: UxaC; cl00829 1114958011011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011012 putative substrate translocation pore; other site 1114958011013 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114958011014 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1114958011015 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114958011016 PYR/PP interface [polypeptide binding]; other site 1114958011017 dimer interface [polypeptide binding]; other site 1114958011018 TPP binding site [chemical binding]; other site 1114958011019 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1114958011020 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1114958011021 TPP-binding site; other site 1114958011022 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958011023 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114958011024 substrate binding site [chemical binding]; other site 1114958011025 ATP binding site [chemical binding]; other site 1114958011026 KduI/IolB family; Region: KduI; cl01508 1114958011027 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114958011028 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114958011029 tetrameric interface [polypeptide binding]; other site 1114958011030 NAD binding site [chemical binding]; other site 1114958011031 catalytic residues [active] 1114958011032 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958011033 Helix-turn-helix domains; Region: HTH; cl00088 1114958011034 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1114958011035 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114958011036 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958011037 active site 1114958011038 catalytic tetrad [active] 1114958011039 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114958011040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011041 putative substrate translocation pore; other site 1114958011042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011043 heat shock protein 90; Provisional; Region: PRK05218 1114958011044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958011045 ATP binding site [chemical binding]; other site 1114958011046 Mg2+ binding site [ion binding]; other site 1114958011047 G-X-G motif; other site 1114958011048 short chain dehydrogenase; Validated; Region: PRK08589 1114958011049 classical (c) SDRs; Region: SDR_c; cd05233 1114958011050 NAD(P) binding site [chemical binding]; other site 1114958011051 active site 1114958011052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958011053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958011054 active site 1114958011055 phosphorylation site [posttranslational modification] 1114958011056 intermolecular recognition site; other site 1114958011057 dimerization interface [polypeptide binding]; other site 1114958011058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958011059 DNA binding residues [nucleotide binding] 1114958011060 dimerization interface [polypeptide binding]; other site 1114958011061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958011062 Histidine kinase; Region: HisKA_3; pfam07730 1114958011063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114958011064 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1114958011065 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1114958011066 putative di-iron ligands [ion binding]; other site 1114958011067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958011068 Helix-turn-helix domains; Region: HTH; cl00088 1114958011069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958011070 Helix-turn-helix domains; Region: HTH; cl00088 1114958011071 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114958011072 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114958011073 NAD(P) binding site [chemical binding]; other site 1114958011074 catalytic residues [active] 1114958011075 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1114958011076 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1114958011077 Trp docking motif [polypeptide binding]; other site 1114958011078 active site 1114958011079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958011080 putative DNA binding site [nucleotide binding]; other site 1114958011081 dimerization interface [polypeptide binding]; other site 1114958011082 putative Zn2+ binding site [ion binding]; other site 1114958011083 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958011084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011085 putative substrate translocation pore; other site 1114958011086 RDD family; Region: RDD; cl00746 1114958011087 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958011088 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114958011089 active site 1114958011090 metal binding site [ion binding]; metal-binding site 1114958011091 peroxiredoxin; Region: AhpC; TIGR03137 1114958011092 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1114958011093 dimer interface [polypeptide binding]; other site 1114958011094 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114958011095 catalytic triad [active] 1114958011096 peroxidatic and resolving cysteines [active] 1114958011097 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1114958011098 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1114958011099 catalytic residue [active] 1114958011100 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1114958011101 catalytic residues [active] 1114958011102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958011103 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1114958011104 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1114958011105 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1114958011106 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1114958011107 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114958011108 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1114958011109 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 1114958011110 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114958011111 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1114958011112 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114958011113 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1114958011114 Ligand binding site; other site 1114958011115 metal-binding site 1114958011116 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1114958011117 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1114958011118 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1114958011119 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1114958011120 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114958011121 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114958011122 P-loop; other site 1114958011123 Magnesium ion binding site [ion binding]; other site 1114958011124 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114958011125 Magnesium ion binding site [ion binding]; other site 1114958011126 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 1114958011127 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 1114958011128 YyzF-like protein; Region: YyzF; cl15733 1114958011129 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1114958011130 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1114958011131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958011132 active site 1114958011133 catalytic tetrad [active] 1114958011134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958011135 Coenzyme A binding pocket [chemical binding]; other site 1114958011136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958011137 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958011138 Arginase family; Region: Arginase; cl00306 1114958011139 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1114958011140 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1114958011141 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958011142 inhibitor-cofactor binding pocket; inhibition site 1114958011143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958011144 catalytic residue [active] 1114958011145 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1114958011146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958011147 Walker A motif; other site 1114958011148 ATP binding site [chemical binding]; other site 1114958011149 Walker B motif; other site 1114958011150 arginine finger; other site 1114958011151 Helix-turn-helix domains; Region: HTH; cl00088 1114958011152 JmjC domain, hydroxylase; Region: JmjC; cl15814 1114958011153 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958011154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958011155 Walker A/P-loop; other site 1114958011156 ATP binding site [chemical binding]; other site 1114958011157 Q-loop/lid; other site 1114958011158 ABC transporter signature motif; other site 1114958011159 Walker B; other site 1114958011160 D-loop; other site 1114958011161 H-loop/switch region; other site 1114958011162 ABC transporter; Region: ABC_tran_2; pfam12848 1114958011163 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1114958011164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011165 putative substrate translocation pore; other site 1114958011166 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1114958011167 hypothetical protein; Provisional; Region: PRK08328 1114958011168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958011169 ATP binding site [chemical binding]; other site 1114958011170 substrate interface [chemical binding]; other site 1114958011171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958011172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958011173 dimerization interface [polypeptide binding]; other site 1114958011174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958011175 dimer interface [polypeptide binding]; other site 1114958011176 phosphorylation site [posttranslational modification] 1114958011177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958011178 ATP binding site [chemical binding]; other site 1114958011179 Mg2+ binding site [ion binding]; other site 1114958011180 G-X-G motif; other site 1114958011181 Helix-turn-helix domains; Region: HTH; cl00088 1114958011182 DNA binding site [nucleotide binding] 1114958011183 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1114958011184 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958011185 protein binding site [polypeptide binding]; other site 1114958011186 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958011187 YycH protein; Region: YycI; cl02015 1114958011188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1114958011189 YycH protein; Region: YycH; pfam07435 1114958011190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1114958011191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958011192 dimerization interface [polypeptide binding]; other site 1114958011193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114958011194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958011195 dimer interface [polypeptide binding]; other site 1114958011196 phosphorylation site [posttranslational modification] 1114958011197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958011198 ATP binding site [chemical binding]; other site 1114958011199 Mg2+ binding site [ion binding]; other site 1114958011200 G-X-G motif; other site 1114958011201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958011202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958011203 active site 1114958011204 phosphorylation site [posttranslational modification] 1114958011205 intermolecular recognition site; other site 1114958011206 dimerization interface [polypeptide binding]; other site 1114958011207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958011208 DNA binding site [nucleotide binding] 1114958011209 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1114958011210 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1114958011211 GDP-binding site [chemical binding]; other site 1114958011212 ACT binding site; other site 1114958011213 IMP binding site; other site 1114958011214 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958011215 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114958011216 active site 1114958011217 metal binding site [ion binding]; metal-binding site 1114958011218 replicative DNA helicase; Provisional; Region: PRK05748 1114958011219 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1114958011220 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1114958011221 Walker A motif; other site 1114958011222 ATP binding site [chemical binding]; other site 1114958011223 Walker B motif; other site 1114958011224 DNA binding loops [nucleotide binding] 1114958011225 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1114958011226 YycC-like protein; Region: YycC; pfam14174 1114958011227 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958011228 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114958011229 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958011230 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958011231 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114958011232 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1114958011233 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114958011234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958011235 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1114958011236 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1114958011237 active site 1114958011238 substrate binding site [chemical binding]; other site 1114958011239 ATP binding site [chemical binding]; other site 1114958011240 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1114958011241 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1114958011242 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1114958011243 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1114958011244 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1114958011245 DHH family; Region: DHH; pfam01368 1114958011246 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1114958011247 Coat F domain; Region: Coat_F; cl15836 1114958011248 Helix-turn-helix domains; Region: HTH; cl00088 1114958011249 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1114958011250 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1114958011251 DHHA2 domain; Region: DHHA2; pfam02833 1114958011252 EamA-like transporter family; Region: EamA; cl01037 1114958011253 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114958011254 EamA-like transporter family; Region: EamA; cl01037 1114958011255 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1114958011256 active site 1114958011257 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1114958011258 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1114958011259 substrate binding [chemical binding]; other site 1114958011260 active site 1114958011261 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1114958011262 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1114958011263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958011264 DNA-binding site [nucleotide binding]; DNA binding site 1114958011265 FCD domain; Region: FCD; cl11656 1114958011266 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1114958011267 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958011268 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 1114958011269 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1114958011270 dimer interface [polypeptide binding]; other site 1114958011271 FMN binding site [chemical binding]; other site 1114958011272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958011273 Helix-turn-helix domains; Region: HTH; cl00088 1114958011274 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958011275 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958011276 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1114958011277 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958011278 Helix-turn-helix domains; Region: HTH; cl00088 1114958011279 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1114958011280 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1114958011281 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1114958011282 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114958011283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958011284 Helix-turn-helix domains; Region: HTH; cl00088 1114958011285 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1114958011286 putative dimerization interface [polypeptide binding]; other site 1114958011287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958011288 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1114958011289 NAD(P) binding site [chemical binding]; other site 1114958011290 active site 1114958011291 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958011292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958011293 DNA-binding site [nucleotide binding]; DNA binding site 1114958011294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958011295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958011296 homodimer interface [polypeptide binding]; other site 1114958011297 catalytic residue [active] 1114958011298 EamA-like transporter family; Region: EamA; cl01037 1114958011299 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114958011300 EamA-like transporter family; Region: EamA; cl01037 1114958011301 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1114958011302 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958011303 Helix-turn-helix domains; Region: HTH; cl00088 1114958011304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1114958011305 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114958011306 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1114958011307 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114958011308 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1114958011309 DNA binding residues [nucleotide binding] 1114958011310 drug binding residues [chemical binding]; other site 1114958011311 dimer interface [polypeptide binding]; other site 1114958011312 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1114958011313 Protein of unknown function (DUF554); Region: DUF554; cl00784 1114958011314 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1114958011315 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114958011316 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1114958011317 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1114958011318 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1114958011319 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1114958011320 CAAX protease self-immunity; Region: Abi; cl00558 1114958011321 benzoate transport; Region: 2A0115; TIGR00895 1114958011322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011323 putative substrate translocation pore; other site 1114958011324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011325 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1114958011326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958011327 putative metal binding site [ion binding]; other site 1114958011328 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958011329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958011330 DNA binding site [nucleotide binding] 1114958011331 domain linker motif; other site 1114958011332 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1114958011333 putative dimerization interface [polypeptide binding]; other site 1114958011334 putative ligand binding site [chemical binding]; other site 1114958011335 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1114958011336 active site 1114958011337 putative catalytic site [active] 1114958011338 DNA binding site [nucleotide binding] 1114958011339 putative phosphate binding site [ion binding]; other site 1114958011340 metal binding site A [ion binding]; metal-binding site 1114958011341 AP binding site [nucleotide binding]; other site 1114958011342 metal binding site B [ion binding]; metal-binding site 1114958011343 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1114958011344 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114958011345 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114958011346 DNA binding site [nucleotide binding] 1114958011347 active site 1114958011348 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1114958011349 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1114958011350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958011351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958011352 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 1114958011353 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114958011354 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114958011355 dimer interface [polypeptide binding]; other site 1114958011356 ssDNA binding site [nucleotide binding]; other site 1114958011357 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958011358 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1114958011359 GTP-binding protein YchF; Reviewed; Region: PRK09601 1114958011360 YchF GTPase; Region: YchF; cd01900 1114958011361 G1 box; other site 1114958011362 GTP/Mg2+ binding site [chemical binding]; other site 1114958011363 Switch I region; other site 1114958011364 G2 box; other site 1114958011365 Switch II region; other site 1114958011366 G3 box; other site 1114958011367 G4 box; other site 1114958011368 G5 box; other site 1114958011369 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1114958011370 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1114958011371 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1114958011372 putative [4Fe-4S] binding site [ion binding]; other site 1114958011373 putative molybdopterin cofactor binding site [chemical binding]; other site 1114958011374 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1114958011375 molybdopterin cofactor binding site; other site 1114958011376 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 1114958011377 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1114958011378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958011379 Coenzyme A binding pocket [chemical binding]; other site 1114958011380 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1114958011381 ParB-like partition proteins; Region: parB_part; TIGR00180 1114958011382 ParB-like nuclease domain; Region: ParBc; cl02129 1114958011383 KorB domain; Region: KorB; pfam08535 1114958011384 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114958011385 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1114958011386 ParB-like partition proteins; Region: parB_part; TIGR00180 1114958011387 ParB-like nuclease domain; Region: ParBc; cl02129 1114958011388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1114958011389 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1114958011390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958011391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958011392 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1114958011393 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1114958011394 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1114958011395 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1114958011396 G1 box; other site 1114958011397 GTP/Mg2+ binding site [chemical binding]; other site 1114958011398 Switch I region; other site 1114958011399 G2 box; other site 1114958011400 Switch II region; other site 1114958011401 G3 box; other site 1114958011402 G4 box; other site 1114958011403 G5 box; other site 1114958011404 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1114958011405 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1114958011406 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1114958011407 G-X-X-G motif; other site 1114958011408 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1114958011409 RxxxH motif; other site 1114958011410 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1114958011411 Ribonuclease P; Region: Ribonuclease_P; cl00457