-- dump date   	20140618_212042
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
592021000001	Lysozyme-like; Region: Lysozyme_like; pfam13702
592021000002	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
592021000003	NlpC/P60 family; Region: NLPC_P60; pfam00877
592021000004	AAA-like domain; Region: AAA_10; pfam12846
592021000005	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
592021000006	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
592021000007	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
592021000008	Walker A motif; other site
592021000009	ATP binding site [chemical binding]; other site
592021000010	Walker B motif; other site
592021000011	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
592021000012	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
592021000013	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
592021000014	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
592021000015	P-loop; other site
592021000016	Magnesium ion binding site [ion binding]; other site
592021000017	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
592021000018	Magnesium ion binding site [ion binding]; other site
592021000019	S-layer homology domain; Region: SLH; pfam00395
592021000020	S-layer homology domain; Region: SLH; pfam00395
592021000021	S-layer homology domain; Region: SLH; pfam00395
592021000022	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
592021000023	active site
592021000024	metal binding site [ion binding]; metal-binding site
592021000025	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
592021000026	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
592021000027	CAAX protease self-immunity; Region: Abi; pfam02517
592021000028	Uncharacterized conserved protein [Function unknown]; Region: COG1683
592021000029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021000030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021000031	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
592021000032	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
592021000033	Mga helix-turn-helix domain; Region: Mga; pfam05043
592021000034	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
592021000035	active site
592021000036	P-loop; other site
592021000037	phosphorylation site [posttranslational modification]
592021000038	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
592021000039	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
592021000040	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
592021000041	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
592021000042	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
592021000043	putative active site [active]
592021000044	putative metal binding site [ion binding]; other site
592021000045	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
592021000046	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
592021000047	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
592021000048	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021000049	dimerization interface [polypeptide binding]; other site
592021000050	putative DNA binding site [nucleotide binding]; other site
592021000051	putative Zn2+ binding site [ion binding]; other site
592021000052	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
592021000053	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
592021000054	Catalytic site [active]
592021000055	Histidine kinase N terminal; Region: HisK_N; pfam09385
592021000056	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
592021000057	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
592021000058	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
592021000059	Mga helix-turn-helix domain; Region: Mga; pfam05043
592021000060	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021000061	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021000062	peptide binding site [polypeptide binding]; other site
592021000063	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
592021000064	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021000065	DNA binding residues [nucleotide binding]
592021000066	DNA polymerase IV; Reviewed; Region: PRK03103
592021000067	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
592021000068	active site
592021000069	DNA binding site [nucleotide binding]
592021000070	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
592021000071	YolD-like protein; Region: YolD; pfam08863
592021000072	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
592021000073	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
592021000074	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
592021000075	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
592021000076	active site
592021000077	catalytic residues [active]
592021000078	DNA binding site [nucleotide binding]
592021000079	Int/Topo IB signature motif; other site
592021000080	CAAX protease self-immunity; Region: Abi; pfam02517
592021000081	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
592021000082	Toprim-like; Region: Toprim_2; pfam13155
592021000083	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
592021000084	Nuclease-related domain; Region: NERD; pfam08378
592021000085	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
592021000086	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
592021000087	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
592021000088	putative active site [active]
592021000089	putative NTP binding site [chemical binding]; other site
592021000090	putative nucleic acid binding site [nucleotide binding]; other site
592021000091	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
592021000092	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
592021000093	active site
592021000094	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
592021000095	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021000096	S-adenosylmethionine binding site [chemical binding]; other site
592021000097	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
592021000098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021000099	non-specific DNA binding site [nucleotide binding]; other site
592021000100	sequence-specific DNA binding site [nucleotide binding]; other site
592021000101	salt bridge; other site
592021000102	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
592021000103	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
592021000104	active site
592021000105	catalytic residues [active]
592021000106	DNA binding site [nucleotide binding]
592021000107	Int/Topo IB signature motif; other site
592021000108	HEPN domain; Region: HEPN; pfam05168
592021000109	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
592021000110	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
592021000111	putative active site [active]
592021000112	putative NTP binding site [chemical binding]; other site
592021000113	putative nucleic acid binding site [nucleotide binding]; other site
592021000114	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
592021000115	active site
592021000116	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
592021000117	active site
592021000118	NTP binding site [chemical binding]; other site
592021000119	metal binding triad [ion binding]; metal-binding site
592021000120	antibiotic binding site [chemical binding]; other site
592021000121	Divergent AAA domain; Region: AAA_4; pfam04326
592021000122	30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806
592021000123	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
592021000124	metal binding triad [ion binding]; metal-binding site
592021000125	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
592021000126	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021000127	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021000128	putative acetyltransferase; Provisional; Region: PRK03624
592021000129	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021000130	Coenzyme A binding pocket [chemical binding]; other site
592021000131	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
592021000132	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
592021000133	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021000134	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021000135	non-specific DNA binding site [nucleotide binding]; other site
592021000136	salt bridge; other site
592021000137	sequence-specific DNA binding site [nucleotide binding]; other site
592021000138	Domain of unknown function (DUF373); Region: DUF373; cl12079
592021000139	AAA-like domain; Region: AAA_10; pfam12846
592021000140	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
592021000141	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
592021000142	Replication-relaxation; Region: Replic_Relax; pfam13814
592021000143	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
592021000144	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
592021000145	DNA binding residues [nucleotide binding]
592021000146	Domain of unknown function (DUF4320); Region: DUF4320; pfam14208
592021000147	S-layer homology domain; Region: SLH; pfam00395
592021000148	S-layer homology domain; Region: SLH; pfam00395
592021000149	S-layer homology domain; Region: SLH; pfam00395
592021000150	AAA domain; Region: AAA_31; pfam13614
592021000151	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
592021000152	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
592021000153	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
592021000154	Walker A motif; other site
592021000155	ATP binding site [chemical binding]; other site
592021000156	Walker B motif; other site
592021000157	WxL domain surface cell wall-binding; Region: WxL; pfam13731
592021000158	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
592021000159	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
592021000160	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
592021000161	active site
592021000162	metal binding site [ion binding]; metal-binding site
592021000163	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
592021000164	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
592021000165	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
592021000166	PrgI family protein; Region: PrgI; pfam12666
592021000167	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
592021000168	CAAX protease self-immunity; Region: Abi; pfam02517
592021000169	Predicted membrane protein [Function unknown]; Region: COG2311
592021000170	Protein of unknown function (DUF418); Region: DUF418; cl12135
592021000171	Protein of unknown function (DUF418); Region: DUF418; pfam04235
592021000172	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
592021000173	catalytic residues [active]
592021000174	S-layer homology domain; Region: SLH; pfam00395
592021000175	S-layer homology domain; Region: SLH; pfam00395
592021000176	S-layer homology domain; Region: SLH; pfam00395
592021000177	Acetokinase family; Region: Acetate_kinase; cl17229
592021000178	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
592021000179	active site
592021000180	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
592021000181	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
592021000182	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
592021000183	active site
592021000184	tetramer interface; other site
592021000185	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
592021000186	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
592021000187	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
592021000188	Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737
592021000189	Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497
592021000190	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
592021000191	HTH domain; Region: HTH_11; cl17392
592021000192	Mga helix-turn-helix domain; Region: Mga; pfam05043
592021000193	PRD domain; Region: PRD; pfam00874
592021000194	PRD domain; Region: PRD; pfam00874
592021000195	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
592021000196	Histidine kinase N terminal; Region: HisK_N; pfam09385
592021000197	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
592021000198	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
592021000199	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
592021000200	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
592021000201	catalytic residues [active]
592021000202	catalytic nucleophile [active]
592021000203	Presynaptic Site I dimer interface [polypeptide binding]; other site
592021000204	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
592021000205	Synaptic Flat tetramer interface [polypeptide binding]; other site
592021000206	Synaptic Site I dimer interface [polypeptide binding]; other site
592021000207	DNA binding site [nucleotide binding]
592021000208	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
592021000209	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
592021000210	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
592021000211	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
592021000212	PA14 domain; Region: PA14; pfam07691
592021000213	Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495
592021000214	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021000215	dimerization interface [polypeptide binding]; other site
592021000216	putative DNA binding site [nucleotide binding]; other site
592021000217	putative Zn2+ binding site [ion binding]; other site
592021000218	Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737
592021000219	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
592021000220	Anthrax toxin lethal factor, middle domain; Region: Anthrax-tox_M; pfam09156
592021000221	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
592021000222	active site
592021000223	conformational flexibility of ligand binding pocket; other site
592021000224	ADP-ribosylating toxin turn-turn motif; other site
592021000225	Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737
592021000226	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
592021000227	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
592021000228	active site
592021000229	Int/Topo IB signature motif; other site
592021000230	DNA binding site [nucleotide binding]
592021000231	Helix-turn-helix domain; Region: HTH_17; pfam12728
592021000232	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
592021000233	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
592021000234	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
592021000235	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
592021000236	Homeodomain-like domain; Region: HTH_23; cl17451
592021000237	Homeodomain-like domain; Region: HTH_23; cl17451
592021000238	YodA lipocalin-like domain; Region: YodA; pfam09223
592021000239	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
592021000240	synthetase active site [active]
592021000241	NTP binding site [chemical binding]; other site
592021000242	metal binding site [ion binding]; metal-binding site
592021000243	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
592021000244	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
592021000245	active site
592021000246	DNA binding site [nucleotide binding]
592021000247	Int/Topo IB signature motif; other site
592021000248	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
592021000249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
592021000250	Walker A motif; other site
592021000251	ATP binding site [chemical binding]; other site
592021000252	Walker B motif; other site
592021000253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
592021000254	TPR motif; other site
592021000255	binding surface
592021000256	Tetratricopeptide repeat; Region: TPR_12; pfam13424
592021000257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021000258	TPR motif; other site
592021000259	binding surface
592021000260	bacterial Hfq-like; Region: Hfq; cd01716
592021000261	hexamer interface [polypeptide binding]; other site
592021000262	Sm1 motif; other site
592021000263	RNA binding site [nucleotide binding]; other site
592021000264	Sm2 motif; other site
592021000265	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021000266	dimerization interface [polypeptide binding]; other site
592021000267	putative DNA binding site [nucleotide binding]; other site
592021000268	putative Zn2+ binding site [ion binding]; other site
592021000269	Staphylococcal nuclease homologues; Region: SNc; smart00318
592021000270	Catalytic site; other site
592021000271	Staphylococcal nuclease homologue; Region: SNase; pfam00565
592021000272	DNA topoisomerase III; Provisional; Region: PRK07726
592021000273	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
592021000274	active site
592021000275	putative interdomain interaction site [polypeptide binding]; other site
592021000276	putative metal-binding site [ion binding]; other site
592021000277	putative nucleotide binding site [chemical binding]; other site
592021000278	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
592021000279	domain I; other site
592021000280	DNA binding groove [nucleotide binding]
592021000281	phosphate binding site [ion binding]; other site
592021000282	domain II; other site
592021000283	domain III; other site
592021000284	nucleotide binding site [chemical binding]; other site
592021000285	catalytic site [active]
592021000286	domain IV; other site
592021000287	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
592021000288	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
592021000289	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
592021000290	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
592021000291	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
592021000292	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
592021000293	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
592021000294	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
592021000295	DnaA N-terminal domain; Region: DnaA_N; pfam11638
592021000296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021000297	Walker A motif; other site
592021000298	ATP binding site [chemical binding]; other site
592021000299	Walker B motif; other site
592021000300	arginine finger; other site
592021000301	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
592021000302	DnaA box-binding interface [nucleotide binding]; other site
592021000303	DNA polymerase III subunit beta; Validated; Region: PRK05643
592021000304	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
592021000305	putative DNA binding surface [nucleotide binding]; other site
592021000306	dimer interface [polypeptide binding]; other site
592021000307	beta-clamp/clamp loader binding surface; other site
592021000308	beta-clamp/translesion DNA polymerase binding surface; other site
592021000309	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
592021000310	recombination protein F; Reviewed; Region: recF; PRK00064
592021000311	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
592021000312	Walker A/P-loop; other site
592021000313	ATP binding site [chemical binding]; other site
592021000314	Q-loop/lid; other site
592021000315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021000316	ABC transporter signature motif; other site
592021000317	Walker B; other site
592021000318	D-loop; other site
592021000319	H-loop/switch region; other site
592021000320	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
592021000321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021000322	Mg2+ binding site [ion binding]; other site
592021000323	G-X-G motif; other site
592021000324	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
592021000325	anchoring element; other site
592021000326	dimer interface [polypeptide binding]; other site
592021000327	ATP binding site [chemical binding]; other site
592021000328	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
592021000329	active site
592021000330	putative metal-binding site [ion binding]; other site
592021000331	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
592021000332	DNA gyrase subunit A; Validated; Region: PRK05560
592021000333	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
592021000334	CAP-like domain; other site
592021000335	active site
592021000336	primary dimer interface [polypeptide binding]; other site
592021000337	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021000338	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021000339	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021000340	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021000341	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021000342	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021000343	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
592021000344	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
592021000345	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
592021000346	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
592021000347	active site
592021000348	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
592021000349	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021000350	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
592021000351	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
592021000352	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
592021000353	active site
592021000354	multimer interface [polypeptide binding]; other site
592021000355	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
592021000356	predicted active site [active]
592021000357	catalytic triad [active]
592021000358	seryl-tRNA synthetase; Provisional; Region: PRK05431
592021000359	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
592021000360	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
592021000361	dimer interface [polypeptide binding]; other site
592021000362	active site
592021000363	motif 1; other site
592021000364	motif 2; other site
592021000365	motif 3; other site
592021000366	Domain of unknown function (DUF3797); Region: DUF3797; pfam12677
592021000367	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
592021000368	DNA binding residues [nucleotide binding]
592021000369	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
592021000370	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
592021000371	Substrate-binding site [chemical binding]; other site
592021000372	Substrate specificity [chemical binding]; other site
592021000373	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
592021000374	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
592021000375	Substrate-binding site [chemical binding]; other site
592021000376	Substrate specificity [chemical binding]; other site
592021000377	Isochorismatase family; Region: Isochorismatase; pfam00857
592021000378	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
592021000379	catalytic triad [active]
592021000380	conserved cis-peptide bond; other site
592021000381	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
592021000382	nucleoside/Zn binding site; other site
592021000383	dimer interface [polypeptide binding]; other site
592021000384	catalytic motif [active]
592021000385	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
592021000386	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021000387	Walker A motif; other site
592021000388	ATP binding site [chemical binding]; other site
592021000389	Walker B motif; other site
592021000390	arginine finger; other site
592021000391	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
592021000392	hypothetical protein; Validated; Region: PRK00153
592021000393	recombination protein RecR; Reviewed; Region: recR; PRK00076
592021000394	RecR protein; Region: RecR; pfam02132
592021000395	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
592021000396	putative active site [active]
592021000397	putative metal-binding site [ion binding]; other site
592021000398	tetramer interface [polypeptide binding]; other site
592021000399	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
592021000400	pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862
592021000401	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
592021000402	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
592021000403	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
592021000404	homodimer interface [polypeptide binding]; other site
592021000405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021000406	catalytic residue [active]
592021000407	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
592021000408	thymidylate kinase; Validated; Region: tmk; PRK00698
592021000409	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
592021000410	TMP-binding site; other site
592021000411	ATP-binding site [chemical binding]; other site
592021000412	DNA polymerase III subunit delta'; Validated; Region: PRK08058
592021000413	DNA polymerase III subunit delta'; Validated; Region: PRK08485
592021000414	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
592021000415	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
592021000416	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
592021000417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021000418	S-adenosylmethionine binding site [chemical binding]; other site
592021000419	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
592021000420	GIY-YIG motif/motif A; other site
592021000421	putative active site [active]
592021000422	putative metal binding site [ion binding]; other site
592021000423	Predicted methyltransferases [General function prediction only]; Region: COG0313
592021000424	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
592021000425	putative SAM binding site [chemical binding]; other site
592021000426	putative homodimer interface [polypeptide binding]; other site
592021000427	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
592021000428	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
592021000429	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
592021000430	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
592021000431	active site
592021000432	HIGH motif; other site
592021000433	KMSKS motif; other site
592021000434	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
592021000435	tRNA binding surface [nucleotide binding]; other site
592021000436	anticodon binding site; other site
592021000437	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
592021000438	dimer interface [polypeptide binding]; other site
592021000439	putative tRNA-binding site [nucleotide binding]; other site
592021000440	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
592021000441	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
592021000442	active site
592021000443	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
592021000444	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
592021000445	putative active site [active]
592021000446	putative metal binding site [ion binding]; other site
592021000447	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
592021000448	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
592021000449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021000450	S-adenosylmethionine binding site [chemical binding]; other site
592021000451	sporulation peptidase YabG; Region: spore_yabG; TIGR02855
592021000452	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
592021000453	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
592021000454	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
592021000455	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
592021000456	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
592021000457	pur operon repressor; Provisional; Region: PRK09213
592021000458	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
592021000459	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021000460	active site
592021000461	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
592021000462	homotrimer interaction site [polypeptide binding]; other site
592021000463	putative active site [active]
592021000464	regulatory protein SpoVG; Reviewed; Region: PRK13259
592021000465	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
592021000466	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
592021000467	Substrate binding site; other site
592021000468	Mg++ binding site; other site
592021000469	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
592021000470	active site
592021000471	substrate binding site [chemical binding]; other site
592021000472	CoA binding site [chemical binding]; other site
592021000473	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
592021000474	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
592021000475	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021000476	active site
592021000477	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
592021000478	putative active site [active]
592021000479	catalytic residue [active]
592021000480	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
592021000481	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
592021000482	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
592021000483	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021000484	ATP binding site [chemical binding]; other site
592021000485	putative Mg++ binding site [ion binding]; other site
592021000486	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021000487	nucleotide binding region [chemical binding]; other site
592021000488	ATP-binding site [chemical binding]; other site
592021000489	TRCF domain; Region: TRCF; pfam03461
592021000490	stage V sporulation protein T; Region: spore_V_T; TIGR02851
592021000491	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
592021000492	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
592021000493	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
592021000494	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
592021000495	putative SAM binding site [chemical binding]; other site
592021000496	putative homodimer interface [polypeptide binding]; other site
592021000497	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
592021000498	homodimer interface [polypeptide binding]; other site
592021000499	metal binding site [ion binding]; metal-binding site
592021000500	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
592021000501	homodimer interface [polypeptide binding]; other site
592021000502	active site
592021000503	putative chemical substrate binding site [chemical binding]; other site
592021000504	metal binding site [ion binding]; metal-binding site
592021000505	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021000506	RNA binding surface [nucleotide binding]; other site
592021000507	sporulation protein YabP; Region: spore_yabP; TIGR02892
592021000508	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
592021000509	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
592021000510	Septum formation initiator; Region: DivIC; pfam04977
592021000511	hypothetical protein; Provisional; Region: PRK08582
592021000512	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
592021000513	RNA binding site [nucleotide binding]; other site
592021000514	stage II sporulation protein E; Region: spore_II_E; TIGR02865
592021000515	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
592021000516	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
592021000517	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
592021000518	Ligand Binding Site [chemical binding]; other site
592021000519	TilS substrate binding domain; Region: TilS; pfam09179
592021000520	TilS substrate C-terminal domain; Region: TilS_C; smart00977
592021000521	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021000522	active site
592021000523	FtsH Extracellular; Region: FtsH_ext; pfam06480
592021000524	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
592021000525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021000526	Walker A motif; other site
592021000527	ATP binding site [chemical binding]; other site
592021000528	Walker B motif; other site
592021000529	arginine finger; other site
592021000530	Peptidase family M41; Region: Peptidase_M41; pfam01434
592021000531	pantothenate kinase; Reviewed; Region: PRK13318
592021000532	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
592021000533	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
592021000534	dimerization interface [polypeptide binding]; other site
592021000535	domain crossover interface; other site
592021000536	redox-dependent activation switch; other site
592021000537	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
592021000538	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
592021000539	dimer interface [polypeptide binding]; other site
592021000540	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021000541	catalytic residue [active]
592021000542	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
592021000543	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
592021000544	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
592021000545	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
592021000546	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
592021000547	glutamine binding [chemical binding]; other site
592021000548	catalytic triad [active]
592021000549	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
592021000550	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
592021000551	homodimer interface [polypeptide binding]; other site
592021000552	substrate-cofactor binding pocket; other site
592021000553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021000554	catalytic residue [active]
592021000555	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
592021000556	dihydropteroate synthase; Region: DHPS; TIGR01496
592021000557	substrate binding pocket [chemical binding]; other site
592021000558	dimer interface [polypeptide binding]; other site
592021000559	inhibitor binding site; inhibition site
592021000560	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
592021000561	homooctamer interface [polypeptide binding]; other site
592021000562	active site
592021000563	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
592021000564	catalytic center binding site [active]
592021000565	ATP binding site [chemical binding]; other site
592021000566	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021000567	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021000568	non-specific DNA binding site [nucleotide binding]; other site
592021000569	salt bridge; other site
592021000570	sequence-specific DNA binding site [nucleotide binding]; other site
592021000571	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
592021000572	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
592021000573	FMN binding site [chemical binding]; other site
592021000574	active site
592021000575	catalytic residues [active]
592021000576	substrate binding site [chemical binding]; other site
592021000577	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
592021000578	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
592021000579	dimer interface [polypeptide binding]; other site
592021000580	putative anticodon binding site; other site
592021000581	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
592021000582	motif 1; other site
592021000583	active site
592021000584	motif 2; other site
592021000585	motif 3; other site
592021000586	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
592021000587	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
592021000588	UvrB/uvrC motif; Region: UVR; pfam02151
592021000589	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
592021000590	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
592021000591	ADP binding site [chemical binding]; other site
592021000592	phosphagen binding site; other site
592021000593	substrate specificity loop; other site
592021000594	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
592021000595	Clp amino terminal domain; Region: Clp_N; pfam02861
592021000596	Clp amino terminal domain; Region: Clp_N; pfam02861
592021000597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021000598	Walker A motif; other site
592021000599	ATP binding site [chemical binding]; other site
592021000600	Walker B motif; other site
592021000601	arginine finger; other site
592021000602	UvrB/uvrC motif; Region: UVR; pfam02151
592021000603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021000604	Walker A motif; other site
592021000605	ATP binding site [chemical binding]; other site
592021000606	Walker B motif; other site
592021000607	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
592021000608	DNA repair protein RadA; Provisional; Region: PRK11823
592021000609	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
592021000610	Walker A motif/ATP binding site; other site
592021000611	ATP binding site [chemical binding]; other site
592021000612	Walker B motif; other site
592021000613	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
592021000614	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
592021000615	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
592021000616	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
592021000617	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
592021000618	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
592021000619	putative active site [active]
592021000620	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
592021000621	substrate binding site; other site
592021000622	dimer interface; other site
592021000623	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
592021000624	homotrimer interaction site [polypeptide binding]; other site
592021000625	zinc binding site [ion binding]; other site
592021000626	CDP-binding sites; other site
592021000627	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
592021000628	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
592021000629	active site
592021000630	HIGH motif; other site
592021000631	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
592021000632	active site
592021000633	KMSKS motif; other site
592021000634	serine O-acetyltransferase; Region: cysE; TIGR01172
592021000635	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
592021000636	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
592021000637	trimer interface [polypeptide binding]; other site
592021000638	active site
592021000639	substrate binding site [chemical binding]; other site
592021000640	CoA binding site [chemical binding]; other site
592021000641	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
592021000642	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
592021000643	active site
592021000644	HIGH motif; other site
592021000645	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
592021000646	KMSKS motif; other site
592021000647	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
592021000648	tRNA binding surface [nucleotide binding]; other site
592021000649	anticodon binding site; other site
592021000650	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
592021000651	active site
592021000652	metal binding site [ion binding]; metal-binding site
592021000653	dimerization interface [polypeptide binding]; other site
592021000654	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
592021000655	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
592021000656	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
592021000657	YacP-like NYN domain; Region: NYN_YacP; pfam05991
592021000658	RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859
592021000659	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021000660	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
592021000661	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
592021000662	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
592021000663	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
592021000664	putative homodimer interface [polypeptide binding]; other site
592021000665	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
592021000666	heterodimer interface [polypeptide binding]; other site
592021000667	homodimer interface [polypeptide binding]; other site
592021000668	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
592021000669	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
592021000670	23S rRNA interface [nucleotide binding]; other site
592021000671	L7/L12 interface [polypeptide binding]; other site
592021000672	putative thiostrepton binding site; other site
592021000673	L25 interface [polypeptide binding]; other site
592021000674	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
592021000675	mRNA/rRNA interface [nucleotide binding]; other site
592021000676	Ribosomal protein L10 leader
592021000677	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
592021000678	23S rRNA interface [nucleotide binding]; other site
592021000679	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
592021000680	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
592021000681	core dimer interface [polypeptide binding]; other site
592021000682	peripheral dimer interface [polypeptide binding]; other site
592021000683	L10 interface [polypeptide binding]; other site
592021000684	L11 interface [polypeptide binding]; other site
592021000685	putative EF-Tu interaction site [polypeptide binding]; other site
592021000686	putative EF-G interaction site [polypeptide binding]; other site
592021000687	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
592021000688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021000689	S-adenosylmethionine binding site [chemical binding]; other site
592021000690	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
592021000691	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
592021000692	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
592021000693	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
592021000694	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
592021000695	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
592021000696	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
592021000697	RPB10 interaction site [polypeptide binding]; other site
592021000698	RPB1 interaction site [polypeptide binding]; other site
592021000699	RPB11 interaction site [polypeptide binding]; other site
592021000700	RPB3 interaction site [polypeptide binding]; other site
592021000701	RPB12 interaction site [polypeptide binding]; other site
592021000702	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
592021000703	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
592021000704	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
592021000705	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
592021000706	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
592021000707	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
592021000708	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
592021000709	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
592021000710	G-loop; other site
592021000711	DNA binding site [nucleotide binding]
592021000712	hypothetical protein; Provisional; Region: PRK06683
592021000713	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
592021000714	S17 interaction site [polypeptide binding]; other site
592021000715	S8 interaction site; other site
592021000716	16S rRNA interaction site [nucleotide binding]; other site
592021000717	streptomycin interaction site [chemical binding]; other site
592021000718	23S rRNA interaction site [nucleotide binding]; other site
592021000719	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
592021000720	30S ribosomal protein S7; Validated; Region: PRK05302
592021000721	elongation factor G; Reviewed; Region: PRK00007
592021000722	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
592021000723	G1 box; other site
592021000724	putative GEF interaction site [polypeptide binding]; other site
592021000725	GTP/Mg2+ binding site [chemical binding]; other site
592021000726	Switch I region; other site
592021000727	G2 box; other site
592021000728	G3 box; other site
592021000729	Switch II region; other site
592021000730	G4 box; other site
592021000731	G5 box; other site
592021000732	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
592021000733	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
592021000734	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
592021000735	elongation factor Tu; Reviewed; Region: PRK00049
592021000736	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
592021000737	G1 box; other site
592021000738	GEF interaction site [polypeptide binding]; other site
592021000739	GTP/Mg2+ binding site [chemical binding]; other site
592021000740	Switch I region; other site
592021000741	G2 box; other site
592021000742	G3 box; other site
592021000743	Switch II region; other site
592021000744	G4 box; other site
592021000745	G5 box; other site
592021000746	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
592021000747	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
592021000748	Antibiotic Binding Site [chemical binding]; other site
592021000749	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
592021000750	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
592021000751	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
592021000752	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
592021000753	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
592021000754	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
592021000755	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
592021000756	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
592021000757	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
592021000758	putative translocon binding site; other site
592021000759	protein-rRNA interface [nucleotide binding]; other site
592021000760	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
592021000761	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
592021000762	G-X-X-G motif; other site
592021000763	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
592021000764	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
592021000765	23S rRNA interface [nucleotide binding]; other site
592021000766	5S rRNA interface [nucleotide binding]; other site
592021000767	putative antibiotic binding site [chemical binding]; other site
592021000768	L25 interface [polypeptide binding]; other site
592021000769	L27 interface [polypeptide binding]; other site
592021000770	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
592021000771	23S rRNA interface [nucleotide binding]; other site
592021000772	putative translocon interaction site; other site
592021000773	signal recognition particle (SRP54) interaction site; other site
592021000774	L23 interface [polypeptide binding]; other site
592021000775	trigger factor interaction site; other site
592021000776	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
592021000777	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
592021000778	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
592021000779	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
592021000780	RNA binding site [nucleotide binding]; other site
592021000781	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
592021000782	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
592021000783	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
592021000784	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
592021000785	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
592021000786	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
592021000787	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
592021000788	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
592021000789	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
592021000790	5S rRNA interface [nucleotide binding]; other site
592021000791	L27 interface [polypeptide binding]; other site
592021000792	23S rRNA interface [nucleotide binding]; other site
592021000793	L5 interface [polypeptide binding]; other site
592021000794	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
592021000795	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
592021000796	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
592021000797	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
592021000798	23S rRNA binding site [nucleotide binding]; other site
592021000799	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
592021000800	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
592021000801	SecY translocase; Region: SecY; pfam00344
592021000802	adenylate kinase; Reviewed; Region: adk; PRK00279
592021000803	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
592021000804	AMP-binding site [chemical binding]; other site
592021000805	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
592021000806	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
592021000807	active site
592021000808	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
592021000809	rRNA binding site [nucleotide binding]; other site
592021000810	predicted 30S ribosome binding site; other site
592021000811	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
592021000812	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
592021000813	30S ribosomal protein S13; Region: bact_S13; TIGR03631
592021000814	30S ribosomal protein S11; Validated; Region: PRK05309
592021000815	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
592021000816	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
592021000817	alphaNTD - beta interaction site [polypeptide binding]; other site
592021000818	alphaNTD homodimer interface [polypeptide binding]; other site
592021000819	alphaNTD - beta' interaction site [polypeptide binding]; other site
592021000820	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
592021000821	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
592021000822	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
592021000823	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
592021000824	Walker A/P-loop; other site
592021000825	ATP binding site [chemical binding]; other site
592021000826	Q-loop/lid; other site
592021000827	ABC transporter signature motif; other site
592021000828	Walker B; other site
592021000829	D-loop; other site
592021000830	H-loop/switch region; other site
592021000831	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
592021000832	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
592021000833	Walker A/P-loop; other site
592021000834	ATP binding site [chemical binding]; other site
592021000835	Q-loop/lid; other site
592021000836	ABC transporter signature motif; other site
592021000837	Walker B; other site
592021000838	D-loop; other site
592021000839	H-loop/switch region; other site
592021000840	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
592021000841	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
592021000842	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
592021000843	dimerization interface 3.5A [polypeptide binding]; other site
592021000844	active site
592021000845	Ribosomal protein L13 leader
592021000846	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
592021000847	23S rRNA interface [nucleotide binding]; other site
592021000848	L3 interface [polypeptide binding]; other site
592021000849	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
592021000850	Protein of unknown function (DUF2521); Region: DUF2521; pfam10730
592021000851	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
592021000852	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
592021000853	active site
592021000854	metal binding site [ion binding]; metal-binding site
592021000855	Domain of unknown function DUF59; Region: DUF59; pfam01883
592021000856	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
592021000857	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
592021000858	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
592021000859	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
592021000860	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
592021000861	NodB motif; other site
592021000862	putative active site [active]
592021000863	putative catalytic site [active]
592021000864	Arginase family; Region: Arginase; cd09989
592021000865	agmatinase; Region: agmatinase; TIGR01230
592021000866	active site
592021000867	Mn binding site [ion binding]; other site
592021000868	oligomer interface [polypeptide binding]; other site
592021000869	Uncharacterized conserved protein [Function unknown]; Region: COG1624
592021000870	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
592021000871	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
592021000872	YbbR-like protein; Region: YbbR; pfam07949
592021000873	YbbR-like protein; Region: YbbR; pfam07949
592021000874	YbbR-like protein; Region: YbbR; pfam07949
592021000875	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
592021000876	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
592021000877	active site
592021000878	substrate binding site [chemical binding]; other site
592021000879	metal binding site [ion binding]; metal-binding site
592021000880	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
592021000881	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
592021000882	glutaminase active site [active]
592021000883	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
592021000884	dimer interface [polypeptide binding]; other site
592021000885	active site
592021000886	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
592021000887	dimer interface [polypeptide binding]; other site
592021000888	active site
592021000889	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021000890	Transcriptional regulators [Transcription]; Region: GntR; COG1802
592021000891	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021000892	DNA-binding site [nucleotide binding]; DNA binding site
592021000893	FCD domain; Region: FCD; pfam07729
592021000894	fructuronate transporter; Provisional; Region: PRK10034; cl15264
592021000895	gluconate transporter; Region: gntP; TIGR00791
592021000896	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
592021000897	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
592021000898	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
592021000899	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
592021000900	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
592021000901	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
592021000902	DoxX; Region: DoxX; cl17842
592021000903	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
592021000904	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
592021000905	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
592021000906	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021000907	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021000908	DNA binding residues [nucleotide binding]
592021000909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021000910	ABC-ATPase subunit interface; other site
592021000911	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
592021000912	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
592021000913	Walker A/P-loop; other site
592021000914	ATP binding site [chemical binding]; other site
592021000915	Q-loop/lid; other site
592021000916	ABC transporter signature motif; other site
592021000917	Walker B; other site
592021000918	D-loop; other site
592021000919	H-loop/switch region; other site
592021000920	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
592021000921	NIL domain; Region: NIL; pfam09383
592021000922	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
592021000923	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
592021000924	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
592021000925	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
592021000926	putative NAD(P) binding site [chemical binding]; other site
592021000927	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
592021000928	FAD binding domain; Region: FAD_binding_4; pfam01565
592021000929	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021000930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021000931	putative substrate translocation pore; other site
592021000932	Domain of unknown function (DUF3981); Region: DUF3981; pfam13139
592021000933	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
592021000934	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021000935	putative substrate translocation pore; other site
592021000936	Protein of unknown function (DUF3887); Region: DUF3887; pfam13026
592021000937	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
592021000938	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
592021000939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021000940	dimer interface [polypeptide binding]; other site
592021000941	conserved gate region; other site
592021000942	putative PBP binding loops; other site
592021000943	ABC-ATPase subunit interface; other site
592021000944	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
592021000945	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
592021000946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021000947	dimer interface [polypeptide binding]; other site
592021000948	conserved gate region; other site
592021000949	putative PBP binding loops; other site
592021000950	ABC-ATPase subunit interface; other site
592021000951	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
592021000952	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021000953	Walker A/P-loop; other site
592021000954	ATP binding site [chemical binding]; other site
592021000955	Q-loop/lid; other site
592021000956	ABC transporter signature motif; other site
592021000957	Walker B; other site
592021000958	D-loop; other site
592021000959	H-loop/switch region; other site
592021000960	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
592021000961	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
592021000962	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021000963	Walker A/P-loop; other site
592021000964	ATP binding site [chemical binding]; other site
592021000965	Q-loop/lid; other site
592021000966	ABC transporter signature motif; other site
592021000967	Walker B; other site
592021000968	D-loop; other site
592021000969	H-loop/switch region; other site
592021000970	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
592021000971	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021000972	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021000973	peptide binding site [polypeptide binding]; other site
592021000974	YusW-like protein; Region: YusW; pfam14039
592021000975	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021000976	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
592021000977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021000978	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021000979	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021000980	peptide binding site [polypeptide binding]; other site
592021000981	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021000982	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021000983	peptide binding site [polypeptide binding]; other site
592021000984	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021000985	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021000986	active site
592021000987	catalytic tetrad [active]
592021000988	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
592021000989	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
592021000990	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
592021000991	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021000992	dimer interface [polypeptide binding]; other site
592021000993	conserved gate region; other site
592021000994	putative PBP binding loops; other site
592021000995	ABC-ATPase subunit interface; other site
592021000996	DNA binding domain, excisionase family; Region: excise; TIGR01764
592021000997	PBP superfamily domain; Region: PBP_like; pfam12727
592021000998	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021000999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021001000	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
592021001001	putative dimerization interface [polypeptide binding]; other site
592021001002	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021001003	EamA-like transporter family; Region: EamA; pfam00892
592021001004	YrzO-like protein; Region: YrzO; pfam14142
592021001005	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
592021001006	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
592021001007	putative acyl-acceptor binding pocket; other site
592021001008	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021001009	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021001010	DNA binding site [nucleotide binding]
592021001011	domain linker motif; other site
592021001012	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
592021001013	putative ligand binding site [chemical binding]; other site
592021001014	putative dimerization interface [polypeptide binding]; other site
592021001015	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021001016	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021001017	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021001018	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021001019	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
592021001020	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
592021001021	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
592021001022	active site
592021001023	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
592021001024	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
592021001025	C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441
592021001026	lysozyme catalytic site [active]
592021001027	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
592021001028	nucleotide binding site/active site [active]
592021001029	HIT family signature motif; other site
592021001030	catalytic residue [active]
592021001031	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
592021001032	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021001033	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021001034	ABC transporter; Region: ABC_tran_2; pfam12848
592021001035	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021001036	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
592021001037	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
592021001038	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
592021001039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021001040	dimer interface [polypeptide binding]; other site
592021001041	conserved gate region; other site
592021001042	putative PBP binding loops; other site
592021001043	ABC-ATPase subunit interface; other site
592021001044	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
592021001045	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
592021001046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021001047	dimer interface [polypeptide binding]; other site
592021001048	conserved gate region; other site
592021001049	putative PBP binding loops; other site
592021001050	ABC-ATPase subunit interface; other site
592021001051	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
592021001052	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021001053	Walker A/P-loop; other site
592021001054	ATP binding site [chemical binding]; other site
592021001055	Q-loop/lid; other site
592021001056	ABC transporter signature motif; other site
592021001057	Walker B; other site
592021001058	D-loop; other site
592021001059	H-loop/switch region; other site
592021001060	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
592021001061	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
592021001062	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
592021001063	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
592021001064	dimer interface [polypeptide binding]; other site
592021001065	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
592021001066	active site
592021001067	Fe binding site [ion binding]; other site
592021001068	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
592021001069	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
592021001070	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
592021001071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021001072	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021001073	putative substrate translocation pore; other site
592021001074	ATP-grasp domain; Region: ATP-grasp_4; cl17255
592021001075	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
592021001076	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
592021001077	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
592021001078	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
592021001079	helicase 45; Provisional; Region: PTZ00424
592021001080	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
592021001081	ATP binding site [chemical binding]; other site
592021001082	Mg++ binding site [ion binding]; other site
592021001083	motif III; other site
592021001084	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021001085	nucleotide binding region [chemical binding]; other site
592021001086	ATP-binding site [chemical binding]; other site
592021001087	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
592021001088	Rhomboid family; Region: Rhomboid; pfam01694
592021001089	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
592021001090	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
592021001091	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
592021001092	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
592021001093	alanine racemase; Reviewed; Region: alr; PRK00053
592021001094	active site
592021001095	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
592021001096	dimer interface [polypeptide binding]; other site
592021001097	substrate binding site [chemical binding]; other site
592021001098	catalytic residues [active]
592021001099	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
592021001100	PemK-like protein; Region: PemK; pfam02452
592021001101	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
592021001102	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
592021001103	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
592021001104	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
592021001105	RNA binding site [nucleotide binding]; other site
592021001106	hypothetical protein; Provisional; Region: PRK04351
592021001107	SprT homologues; Region: SprT; cl01182
592021001108	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
592021001109	Glycoprotease family; Region: Peptidase_M22; pfam00814
592021001110	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
592021001111	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
592021001112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021001113	Coenzyme A binding pocket [chemical binding]; other site
592021001114	UGMP family protein; Validated; Region: PRK09604
592021001115	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
592021001116	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
592021001117	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
592021001118	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021001119	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021001120	ABC transporter; Region: ABC_tran_2; pfam12848
592021001121	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021001122	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
592021001123	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
592021001124	CoA binding domain; Region: CoA_binding; pfam02629
592021001125	CAAX protease self-immunity; Region: Abi; pfam02517
592021001126	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
592021001127	oligomerisation interface [polypeptide binding]; other site
592021001128	mobile loop; other site
592021001129	roof hairpin; other site
592021001130	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
592021001131	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
592021001132	ring oligomerisation interface [polypeptide binding]; other site
592021001133	ATP/Mg binding site [chemical binding]; other site
592021001134	stacking interactions; other site
592021001135	hinge regions; other site
592021001136	GMP synthase; Reviewed; Region: guaA; PRK00074
592021001137	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
592021001138	AMP/PPi binding site [chemical binding]; other site
592021001139	candidate oxyanion hole; other site
592021001140	catalytic triad [active]
592021001141	potential glutamine specificity residues [chemical binding]; other site
592021001142	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
592021001143	ATP Binding subdomain [chemical binding]; other site
592021001144	Ligand Binding sites [chemical binding]; other site
592021001145	Dimerization subdomain; other site
592021001146	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
592021001147	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021001148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021001149	active site
592021001150	phosphorylation site [posttranslational modification]
592021001151	intermolecular recognition site; other site
592021001152	dimerization interface [polypeptide binding]; other site
592021001153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021001154	DNA binding site [nucleotide binding]
592021001155	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021001156	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021001157	dimerization interface [polypeptide binding]; other site
592021001158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021001159	dimer interface [polypeptide binding]; other site
592021001160	phosphorylation site [posttranslational modification]
592021001161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021001162	ATP binding site [chemical binding]; other site
592021001163	Mg2+ binding site [ion binding]; other site
592021001164	G-X-G motif; other site
592021001165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021001166	S-adenosylmethionine binding site [chemical binding]; other site
592021001167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021001168	S-adenosylmethionine binding site [chemical binding]; other site
592021001169	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
592021001170	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021001171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021001172	S-adenosylmethionine binding site [chemical binding]; other site
592021001173	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
592021001174	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
592021001175	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021001176	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
592021001177	Walker A/P-loop; other site
592021001178	ATP binding site [chemical binding]; other site
592021001179	Q-loop/lid; other site
592021001180	ABC transporter signature motif; other site
592021001181	Walker B; other site
592021001182	D-loop; other site
592021001183	H-loop/switch region; other site
592021001184	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021001185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021001186	dimer interface [polypeptide binding]; other site
592021001187	phosphorylation site [posttranslational modification]
592021001188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021001189	ATP binding site [chemical binding]; other site
592021001190	Mg2+ binding site [ion binding]; other site
592021001191	G-X-G motif; other site
592021001192	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021001193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021001194	active site
592021001195	phosphorylation site [posttranslational modification]
592021001196	intermolecular recognition site; other site
592021001197	dimerization interface [polypeptide binding]; other site
592021001198	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021001199	DNA binding site [nucleotide binding]
592021001200	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
592021001201	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
592021001202	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
592021001203	NAD binding site [chemical binding]; other site
592021001204	ATP-grasp domain; Region: ATP-grasp; pfam02222
592021001205	adenylosuccinate lyase; Provisional; Region: PRK07492
592021001206	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
592021001207	tetramer interface [polypeptide binding]; other site
592021001208	active site
592021001209	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
592021001210	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
592021001211	ATP binding site [chemical binding]; other site
592021001212	active site
592021001213	substrate binding site [chemical binding]; other site
592021001214	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
592021001215	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
592021001216	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
592021001217	putative active site [active]
592021001218	catalytic triad [active]
592021001219	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
592021001220	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
592021001221	dimerization interface [polypeptide binding]; other site
592021001222	ATP binding site [chemical binding]; other site
592021001223	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
592021001224	dimerization interface [polypeptide binding]; other site
592021001225	ATP binding site [chemical binding]; other site
592021001226	amidophosphoribosyltransferase; Provisional; Region: PRK06781
592021001227	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
592021001228	active site
592021001229	tetramer interface [polypeptide binding]; other site
592021001230	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021001231	active site
592021001232	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
592021001233	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
592021001234	dimerization interface [polypeptide binding]; other site
592021001235	putative ATP binding site [chemical binding]; other site
592021001236	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
592021001237	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
592021001238	active site
592021001239	substrate binding site [chemical binding]; other site
592021001240	cosubstrate binding site; other site
592021001241	catalytic site [active]
592021001242	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
592021001243	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
592021001244	purine monophosphate binding site [chemical binding]; other site
592021001245	dimer interface [polypeptide binding]; other site
592021001246	putative catalytic residues [active]
592021001247	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
592021001248	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
592021001249	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
592021001250	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
592021001251	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
592021001252	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
592021001253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
592021001254	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
592021001255	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
592021001256	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
592021001257	PcrB family; Region: PcrB; pfam01884
592021001258	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
592021001259	substrate binding site [chemical binding]; other site
592021001260	putative active site [active]
592021001261	dimer interface [polypeptide binding]; other site
592021001262	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
592021001263	Part of AAA domain; Region: AAA_19; pfam13245
592021001264	Family description; Region: UvrD_C_2; pfam13538
592021001265	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
592021001266	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
592021001267	nucleotide binding pocket [chemical binding]; other site
592021001268	K-X-D-G motif; other site
592021001269	catalytic site [active]
592021001270	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
592021001271	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
592021001272	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
592021001273	Dimer interface [polypeptide binding]; other site
592021001274	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
592021001275	putative dimer interface [polypeptide binding]; other site
592021001276	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
592021001277	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
592021001278	putative dimer interface [polypeptide binding]; other site
592021001279	hypothetical protein; Provisional; Region: PRK10621
592021001280	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
592021001281	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
592021001282	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
592021001283	Glutamate binding site [chemical binding]; other site
592021001284	homodimer interface [polypeptide binding]; other site
592021001285	NAD binding site [chemical binding]; other site
592021001286	catalytic residues [active]
592021001287	Isochorismatase family; Region: Isochorismatase; pfam00857
592021001288	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
592021001289	catalytic triad [active]
592021001290	conserved cis-peptide bond; other site
592021001291	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
592021001292	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
592021001293	Walker A/P-loop; other site
592021001294	ATP binding site [chemical binding]; other site
592021001295	Q-loop/lid; other site
592021001296	ABC transporter signature motif; other site
592021001297	Walker B; other site
592021001298	D-loop; other site
592021001299	H-loop/switch region; other site
592021001300	NIL domain; Region: NIL; pfam09383
592021001301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021001302	dimer interface [polypeptide binding]; other site
592021001303	conserved gate region; other site
592021001304	ABC-ATPase subunit interface; other site
592021001305	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
592021001306	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
592021001307	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
592021001308	Protein of unknown function (DUF3926); Region: DUF3926; pfam13080
592021001309	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021001310	MarR family; Region: MarR; pfam01047
592021001311	MarR family; Region: MarR_2; cl17246
592021001312	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
592021001313	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
592021001314	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
592021001315	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
592021001316	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
592021001317	GatB domain; Region: GatB_Yqey; pfam02637
592021001318	putative lipid kinase; Reviewed; Region: PRK13337
592021001319	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
592021001320	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
592021001321	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021001322	motif II; other site
592021001323	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
592021001324	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021001325	inhibitor-cofactor binding pocket; inhibition site
592021001326	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021001327	catalytic residue [active]
592021001328	PAS domain; Region: PAS_9; pfam13426
592021001329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021001330	putative active site [active]
592021001331	heme pocket [chemical binding]; other site
592021001332	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
592021001333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021001334	Walker A motif; other site
592021001335	ATP binding site [chemical binding]; other site
592021001336	Walker B motif; other site
592021001337	arginine finger; other site
592021001338	succinic semialdehyde dehydrogenase; Region: PLN02278
592021001339	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
592021001340	tetramerization interface [polypeptide binding]; other site
592021001341	NAD(P) binding site [chemical binding]; other site
592021001342	catalytic residues [active]
592021001343	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
592021001344	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
592021001345	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
592021001346	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
592021001347	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
592021001348	putative active site [active]
592021001349	putative metal binding site [ion binding]; other site
592021001350	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
592021001351	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
592021001352	putative active site [active]
592021001353	putative metal binding site [ion binding]; other site
592021001354	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
592021001355	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
592021001356	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
592021001357	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
592021001358	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
592021001359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021001360	S-adenosylmethionine binding site [chemical binding]; other site
592021001361	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
592021001362	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
592021001363	FMN binding site [chemical binding]; other site
592021001364	active site
592021001365	catalytic residues [active]
592021001366	substrate binding site [chemical binding]; other site
592021001367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
592021001368	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
592021001369	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
592021001370	Protein of unknown function DUF45; Region: DUF45; pfam01863
592021001371	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
592021001372	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
592021001373	active site
592021001374	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
592021001375	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
592021001376	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
592021001377	metal binding site [ion binding]; metal-binding site
592021001378	putative dimer interface [polypeptide binding]; other site
592021001379	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021001380	S-adenosylmethionine binding site [chemical binding]; other site
592021001381	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
592021001382	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
592021001383	catalytic residue [active]
592021001384	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
592021001385	catalytic residues [active]
592021001386	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021001387	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021001388	peroxiredoxin; Region: AhpC; TIGR03137
592021001389	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
592021001390	dimer interface [polypeptide binding]; other site
592021001391	decamer (pentamer of dimers) interface [polypeptide binding]; other site
592021001392	catalytic triad [active]
592021001393	peroxidatic and resolving cysteines [active]
592021001394	5-methylribose kinase; Reviewed; Region: PRK12396
592021001395	Phosphotransferase enzyme family; Region: APH; pfam01636
592021001396	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
592021001397	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
592021001398	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
592021001399	intersubunit interface [polypeptide binding]; other site
592021001400	active site
592021001401	Zn2+ binding site [ion binding]; other site
592021001402	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
592021001403	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021001404	ABC-ATPase subunit  interface; other site
592021001405	dimer interface [polypeptide binding]; other site
592021001406	putative PBP binding regions; other site
592021001407	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
592021001408	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021001409	ABC-ATPase subunit  interface; other site
592021001410	dimer interface [polypeptide binding]; other site
592021001411	putative PBP binding regions; other site
592021001412	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
592021001413	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
592021001414	putative ligand binding residues [chemical binding]; other site
592021001415	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
592021001416	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021001417	DNA binding domain, excisionase family; Region: excise; TIGR01764
592021001418	Sm and related proteins; Region: Sm_like; cl00259
592021001419	Sm1 motif; other site
592021001420	RNA binding site [nucleotide binding]; other site
592021001421	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
592021001422	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
592021001423	hypothetical protein; Provisional; Region: PRK06851
592021001424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
592021001425	Walker A motif; other site
592021001426	ATP binding site [chemical binding]; other site
592021001427	NTPase; Region: NTPase_1; cl17478
592021001428	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
592021001429	benzoate transport; Region: 2A0115; TIGR00895
592021001430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021001431	putative substrate translocation pore; other site
592021001432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021001433	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
592021001434	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
592021001435	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
592021001436	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
592021001437	[2Fe-2S] cluster binding site [ion binding]; other site
592021001438	Fatty acid desaturase; Region: FA_desaturase; pfam00487
592021001439	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
592021001440	putative di-iron ligands [ion binding]; other site
592021001441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021001442	dimer interface [polypeptide binding]; other site
592021001443	conserved gate region; other site
592021001444	putative PBP binding loops; other site
592021001445	ABC-ATPase subunit interface; other site
592021001446	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
592021001447	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
592021001448	substrate binding pocket [chemical binding]; other site
592021001449	membrane-bound complex binding site; other site
592021001450	hinge residues; other site
592021001451	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
592021001452	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
592021001453	Walker A/P-loop; other site
592021001454	ATP binding site [chemical binding]; other site
592021001455	Q-loop/lid; other site
592021001456	ABC transporter signature motif; other site
592021001457	Walker B; other site
592021001458	D-loop; other site
592021001459	H-loop/switch region; other site
592021001460	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
592021001461	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
592021001462	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021001463	dimerization interface [polypeptide binding]; other site
592021001464	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021001465	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021001466	dimer interface [polypeptide binding]; other site
592021001467	putative CheW interface [polypeptide binding]; other site
592021001468	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
592021001469	HAMP domain; Region: HAMP; pfam00672
592021001470	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021001471	dimer interface [polypeptide binding]; other site
592021001472	putative CheW interface [polypeptide binding]; other site
592021001473	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
592021001474	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
592021001475	Ca binding site [ion binding]; other site
592021001476	active site
592021001477	catalytic site [active]
592021001478	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
592021001479	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
592021001480	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
592021001481	active site turn [active]
592021001482	phosphorylation site [posttranslational modification]
592021001483	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
592021001484	putative catalytic site [active]
592021001485	putative metal binding site [ion binding]; other site
592021001486	putative phosphate binding site [ion binding]; other site
592021001487	Predicted membrane protein [Function unknown]; Region: COG1511
592021001488	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
592021001489	Predicted membrane protein [Function unknown]; Region: COG1511
592021001490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021001491	DNA topoisomerase III; Provisional; Region: PRK07726
592021001492	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
592021001493	active site
592021001494	putative interdomain interaction site [polypeptide binding]; other site
592021001495	putative metal-binding site [ion binding]; other site
592021001496	putative nucleotide binding site [chemical binding]; other site
592021001497	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
592021001498	domain I; other site
592021001499	DNA binding groove [nucleotide binding]
592021001500	phosphate binding site [ion binding]; other site
592021001501	domain II; other site
592021001502	domain III; other site
592021001503	nucleotide binding site [chemical binding]; other site
592021001504	catalytic site [active]
592021001505	domain IV; other site
592021001506	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
592021001507	substrate binding site [chemical binding]; other site
592021001508	multimerization interface [polypeptide binding]; other site
592021001509	ATP binding site [chemical binding]; other site
592021001510	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
592021001511	thiamine phosphate binding site [chemical binding]; other site
592021001512	active site
592021001513	pyrophosphate binding site [ion binding]; other site
592021001514	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
592021001515	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
592021001516	HAMP domain; Region: HAMP; pfam00672
592021001517	dimerization interface [polypeptide binding]; other site
592021001518	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021001519	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021001520	dimer interface [polypeptide binding]; other site
592021001521	putative CheW interface [polypeptide binding]; other site
592021001522	Domain of unknown function DUF77; Region: DUF77; pfam01910
592021001523	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
592021001524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021001525	dimer interface [polypeptide binding]; other site
592021001526	conserved gate region; other site
592021001527	putative PBP binding loops; other site
592021001528	ABC-ATPase subunit interface; other site
592021001529	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
592021001530	NMT1/THI5 like; Region: NMT1; pfam09084
592021001531	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
592021001532	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
592021001533	Walker A/P-loop; other site
592021001534	ATP binding site [chemical binding]; other site
592021001535	Q-loop/lid; other site
592021001536	ABC transporter signature motif; other site
592021001537	Walker B; other site
592021001538	D-loop; other site
592021001539	H-loop/switch region; other site
592021001540	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
592021001541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021001542	Walker A/P-loop; other site
592021001543	ATP binding site [chemical binding]; other site
592021001544	Q-loop/lid; other site
592021001545	ABC transporter signature motif; other site
592021001546	Walker B; other site
592021001547	D-loop; other site
592021001548	H-loop/switch region; other site
592021001549	ABC transporter; Region: ABC_tran_2; pfam12848
592021001550	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021001551	Glyco_18 domain; Region: Glyco_18; smart00636
592021001552	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
592021001553	active site
592021001554	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
592021001555	Interdomain contacts; other site
592021001556	Cytokine receptor motif; other site
592021001557	CBD_II domain; Region: CBD_II; smart00637
592021001558	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
592021001559	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
592021001560	catalytic residues [active]
592021001561	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021001562	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021001563	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
592021001564	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021001565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021001566	putative substrate translocation pore; other site
592021001567	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021001568	non-specific DNA binding site [nucleotide binding]; other site
592021001569	salt bridge; other site
592021001570	sequence-specific DNA binding site [nucleotide binding]; other site
592021001571	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
592021001572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021001573	putative substrate translocation pore; other site
592021001574	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
592021001575	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
592021001576	YesK-like protein; Region: YesK; pfam14150
592021001577	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
592021001578	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
592021001579	nucleotide binding site [chemical binding]; other site
592021001580	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
592021001581	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
592021001582	putative metal binding site [ion binding]; other site
592021001583	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
592021001584	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
592021001585	putative metal binding site [ion binding]; other site
592021001586	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
592021001587	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
592021001588	putative metal binding site [ion binding]; other site
592021001589	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
592021001590	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
592021001591	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
592021001592	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
592021001593	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
592021001594	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
592021001595	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
592021001596	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
592021001597	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
592021001598	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
592021001599	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
592021001600	Low molecular weight phosphatase family; Region: LMWPc; cd00115
592021001601	active site
592021001602	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
592021001603	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
592021001604	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
592021001605	Soluble P-type ATPase [General function prediction only]; Region: COG4087
592021001606	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021001607	EamA-like transporter family; Region: EamA; pfam00892
592021001608	EamA-like transporter family; Region: EamA; pfam00892
592021001609	YhhN-like protein; Region: YhhN; pfam07947
592021001610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021001611	binding surface
592021001612	Tetratricopeptide repeat; Region: TPR_16; pfam13432
592021001613	TPR motif; other site
592021001614	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
592021001615	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
592021001616	Predicted membrane protein [Function unknown]; Region: COG2510
592021001617	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
592021001618	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
592021001619	calcium/proton exchanger (cax); Region: cax; TIGR00378
592021001620	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
592021001621	YfkD-like protein; Region: YfkD; pfam14167
592021001622	Radical SAM superfamily; Region: Radical_SAM; pfam04055
592021001623	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021001624	FeS/SAM binding site; other site
592021001625	YfkB-like domain; Region: YfkB; pfam08756
592021001626	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
592021001627	Fumarase C-terminus; Region: Fumerase_C; pfam05683
592021001628	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
592021001629	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
592021001630	NodB motif; other site
592021001631	active site
592021001632	catalytic site [active]
592021001633	Cd binding site [ion binding]; other site
592021001634	TRAM domain; Region: TRAM; pfam01938
592021001635	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
592021001636	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021001637	S-adenosylmethionine binding site [chemical binding]; other site
592021001638	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
592021001639	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
592021001640	Int/Topo IB signature motif; other site
592021001641	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021001642	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021001643	non-specific DNA binding site [nucleotide binding]; other site
592021001644	salt bridge; other site
592021001645	sequence-specific DNA binding site [nucleotide binding]; other site
592021001646	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021001647	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021001648	non-specific DNA binding site [nucleotide binding]; other site
592021001649	salt bridge; other site
592021001650	sequence-specific DNA binding site [nucleotide binding]; other site
592021001651	phage regulatory protein, rha family; Region: phage_pRha; TIGR02681
592021001652	ORF6C domain; Region: ORF6C; pfam10552
592021001653	Helix-turn-helix domain; Region: HTH_17; pfam12728
592021001654	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
592021001655	hypothetical protein; Validated; Region: PRK08116
592021001656	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021001657	Walker A motif; other site
592021001658	ATP binding site [chemical binding]; other site
592021001659	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
592021001660	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
592021001661	putative metal binding site [ion binding]; other site
592021001662	Protein of unknown function (DUF3983); Region: DUF3983; pfam13137
592021001663	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
592021001664	HNH endonuclease; Region: HNH; pfam01844
592021001665	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
592021001666	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
592021001667	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
592021001668	Phage capsid family; Region: Phage_capsid; pfam05065
592021001669	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
592021001670	oligomerization interface [polypeptide binding]; other site
592021001671	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
592021001672	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
592021001673	Domain of unknown function (DUF947); Region: DUF947; pfam06102
592021001674	Phage-related protein [Function unknown]; Region: COG4722
592021001675	Phage tail protein; Region: Sipho_tail; pfam05709
592021001676	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
592021001677	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
592021001678	Haemolysin XhlA; Region: XhlA; pfam10779
592021001679	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
592021001680	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
592021001681	active site
592021001682	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
592021001683	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
592021001684	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
592021001685	dimerization interface 3.5A [polypeptide binding]; other site
592021001686	active site
592021001687	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
592021001688	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021001689	Walker A motif; other site
592021001690	ATP binding site [chemical binding]; other site
592021001691	Walker B motif; other site
592021001692	arginine finger; other site
592021001693	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
592021001694	hypothetical protein; Validated; Region: PRK06748
592021001695	S-methylmethionine transporter; Provisional; Region: PRK11387
592021001696	acetylornithine deacetylase; Validated; Region: PRK08596
592021001697	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
592021001698	metal binding site [ion binding]; metal-binding site
592021001699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021001700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021001701	non-specific DNA binding site [nucleotide binding]; other site
592021001702	salt bridge; other site
592021001703	sequence-specific DNA binding site [nucleotide binding]; other site
592021001704	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
592021001705	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
592021001706	Domain of unknown function DUF; Region: DUF204; pfam02659
592021001707	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
592021001708	glutaminase A; Region: Gln_ase; TIGR03814
592021001709	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
592021001710	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
592021001711	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
592021001712	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
592021001713	active site turn [active]
592021001714	phosphorylation site [posttranslational modification]
592021001715	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021001716	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021001717	Sm and related proteins; Region: Sm_like; cl00259
592021001718	heptamer interface [polypeptide binding]; other site
592021001719	Sm1 motif; other site
592021001720	hexamer interface [polypeptide binding]; other site
592021001721	RNA binding site [nucleotide binding]; other site
592021001722	Sm2 motif; other site
592021001723	Sm and related proteins; Region: Sm_like; cl00259
592021001724	heptamer interface [polypeptide binding]; other site
592021001725	Sm1 motif; other site
592021001726	hexamer interface [polypeptide binding]; other site
592021001727	RNA binding site [nucleotide binding]; other site
592021001728	Sm2 motif; other site
592021001729	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
592021001730	Ligand binding site; other site
592021001731	Putative Catalytic site; other site
592021001732	DXD motif; other site
592021001733	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
592021001734	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021001735	active site
592021001736	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
592021001737	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
592021001738	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
592021001739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
592021001740	NAD(P) binding site [chemical binding]; other site
592021001741	active site
592021001742	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021001743	active site
592021001744	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
592021001745	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021001746	active site
592021001747	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
592021001748	Pyruvate formate lyase 1; Region: PFL1; cd01678
592021001749	coenzyme A binding site [chemical binding]; other site
592021001750	active site
592021001751	catalytic residues [active]
592021001752	glycine loop; other site
592021001753	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
592021001754	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021001755	FeS/SAM binding site; other site
592021001756	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
592021001757	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
592021001758	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
592021001759	YfhE-like protein; Region: YfhE; pfam14152
592021001760	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021001761	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
592021001762	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
592021001763	active site
592021001764	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
592021001765	TIGR01777 family protein; Region: yfcH
592021001766	putative NAD(P) binding site [chemical binding]; other site
592021001767	putative active site [active]
592021001768	recombination regulator RecX; Provisional; Region: recX; PRK14135
592021001769	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
592021001770	YpzG-like protein; Region: YpzG; pfam14139
592021001771	Small acid-soluble spore protein K family; Region: SspK; pfam08176
592021001772	WVELL protein; Region: WVELL; pfam14043
592021001773	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
592021001774	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
592021001775	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
592021001776	minor groove reading motif; other site
592021001777	helix-hairpin-helix signature motif; other site
592021001778	substrate binding pocket [chemical binding]; other site
592021001779	active site
592021001780	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
592021001781	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
592021001782	DNA binding and oxoG recognition site [nucleotide binding]
592021001783	YgaB-like protein; Region: YgaB; pfam14182
592021001784	hypothetical protein; Provisional; Region: PRK13662
592021001785	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
592021001786	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021001787	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
592021001788	Walker A/P-loop; other site
592021001789	ATP binding site [chemical binding]; other site
592021001790	Q-loop/lid; other site
592021001791	ABC transporter signature motif; other site
592021001792	Walker B; other site
592021001793	D-loop; other site
592021001794	H-loop/switch region; other site
592021001795	Predicted membrane protein [Function unknown]; Region: COG4129
592021001796	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
592021001797	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
592021001798	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
592021001799	active site
592021001800	dimer interface [polypeptide binding]; other site
592021001801	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
592021001802	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
592021001803	active site
592021001804	FMN binding site [chemical binding]; other site
592021001805	substrate binding site [chemical binding]; other site
592021001806	3Fe-4S cluster binding site [ion binding]; other site
592021001807	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
592021001808	domain_subunit interface; other site
592021001809	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
592021001810	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021001811	inhibitor-cofactor binding pocket; inhibition site
592021001812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021001813	catalytic residue [active]
592021001814	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
592021001815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021001816	Walker A/P-loop; other site
592021001817	ATP binding site [chemical binding]; other site
592021001818	Q-loop/lid; other site
592021001819	ABC transporter signature motif; other site
592021001820	Walker B; other site
592021001821	D-loop; other site
592021001822	H-loop/switch region; other site
592021001823	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
592021001824	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
592021001825	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
592021001826	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
592021001827	Ion channel; Region: Ion_trans_2; pfam07885
592021001828	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
592021001829	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
592021001830	catalytic triad [active]
592021001831	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
592021001832	metal binding site 2 [ion binding]; metal-binding site
592021001833	putative DNA binding helix; other site
592021001834	metal binding site 1 [ion binding]; metal-binding site
592021001835	dimer interface [polypeptide binding]; other site
592021001836	structural Zn2+ binding site [ion binding]; other site
592021001837	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
592021001838	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
592021001839	hypothetical protein; Provisional; Region: PRK12378
592021001840	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
592021001841	nudix motif; other site
592021001842	Transglycosylase; Region: Transgly; pfam00912
592021001843	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
592021001844	Thioredoxin; Region: Thioredoxin_4; pfam13462
592021001845	epoxyqueuosine reductase; Region: TIGR00276
592021001846	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
592021001847	Putative amidase domain; Region: Amidase_6; pfam12671
592021001848	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
592021001849	PAS fold; Region: PAS_4; pfam08448
592021001850	PAS domain S-box; Region: sensory_box; TIGR00229
592021001851	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021001852	putative active site [active]
592021001853	heme pocket [chemical binding]; other site
592021001854	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
592021001855	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021001856	metal binding site [ion binding]; metal-binding site
592021001857	active site
592021001858	I-site; other site
592021001859	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
592021001860	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
592021001861	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
592021001862	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
592021001863	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
592021001864	heme-binding site [chemical binding]; other site
592021001865	Leucine rich repeat; Region: LRR_8; pfam13855
592021001866	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
592021001867	Substrate binding site [chemical binding]; other site
592021001868	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
592021001869	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
592021001870	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
592021001871	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
592021001872	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
592021001873	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
592021001874	Leucine rich repeat; Region: LRR_8; pfam13855
592021001875	Leucine rich repeat; Region: LRR_8; pfam13855
592021001876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021001877	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
592021001878	Coenzyme A binding pocket [chemical binding]; other site
592021001879	BCCT family transporter; Region: BCCT; pfam02028
592021001880	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
592021001881	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
592021001882	FOG: PKD repeat [General function prediction only]; Region: COG3291
592021001883	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
592021001884	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
592021001885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
592021001886	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
592021001887	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
592021001888	Cache domain; Region: Cache_1; pfam02743
592021001889	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021001890	dimerization interface [polypeptide binding]; other site
592021001891	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021001892	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021001893	dimer interface [polypeptide binding]; other site
592021001894	putative CheW interface [polypeptide binding]; other site
592021001895	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
592021001896	PAS domain; Region: PAS; smart00091
592021001897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021001898	ATP binding site [chemical binding]; other site
592021001899	Mg2+ binding site [ion binding]; other site
592021001900	G-X-G motif; other site
592021001901	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
592021001902	Citrate transporter; Region: CitMHS; pfam03600
592021001903	hypothetical protein; Provisional; Region: PRK12784
592021001904	NosL; Region: NosL; cl01769
592021001905	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
592021001906	Ankyrin repeat; Region: Ank; pfam00023
592021001907	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
592021001908	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
592021001909	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
592021001910	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
592021001911	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
592021001912	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021001913	Walker A/P-loop; other site
592021001914	ATP binding site [chemical binding]; other site
592021001915	Q-loop/lid; other site
592021001916	ABC transporter signature motif; other site
592021001917	Walker B; other site
592021001918	D-loop; other site
592021001919	H-loop/switch region; other site
592021001920	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
592021001921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021001922	dimer interface [polypeptide binding]; other site
592021001923	conserved gate region; other site
592021001924	putative PBP binding loops; other site
592021001925	ABC-ATPase subunit interface; other site
592021001926	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
592021001927	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
592021001928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021001929	dimer interface [polypeptide binding]; other site
592021001930	conserved gate region; other site
592021001931	putative PBP binding loops; other site
592021001932	ABC-ATPase subunit interface; other site
592021001933	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
592021001934	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
592021001935	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
592021001936	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
592021001937	active site
592021001938	metal binding site [ion binding]; metal-binding site
592021001939	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021001940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021001941	active site
592021001942	phosphorylation site [posttranslational modification]
592021001943	intermolecular recognition site; other site
592021001944	dimerization interface [polypeptide binding]; other site
592021001945	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021001946	DNA binding site [nucleotide binding]
592021001947	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021001948	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021001949	dimer interface [polypeptide binding]; other site
592021001950	phosphorylation site [posttranslational modification]
592021001951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021001952	ATP binding site [chemical binding]; other site
592021001953	Mg2+ binding site [ion binding]; other site
592021001954	G-X-G motif; other site
592021001955	leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300
592021001956	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
592021001957	putative active site [active]
592021001958	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
592021001959	Cache domain; Region: Cache_1; pfam02743
592021001960	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021001961	dimerization interface [polypeptide binding]; other site
592021001962	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021001963	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021001964	dimer interface [polypeptide binding]; other site
592021001965	putative CheW interface [polypeptide binding]; other site
592021001966	sensory histidine kinase DcuS; Provisional; Region: PRK11086
592021001967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021001968	ATP binding site [chemical binding]; other site
592021001969	Mg2+ binding site [ion binding]; other site
592021001970	G-X-G motif; other site
592021001971	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
592021001972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021001973	active site
592021001974	phosphorylation site [posttranslational modification]
592021001975	intermolecular recognition site; other site
592021001976	dimerization interface [polypeptide binding]; other site
592021001977	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
592021001978	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
592021001979	Malic enzyme, N-terminal domain; Region: malic; pfam00390
592021001980	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
592021001981	putative NAD(P) binding site [chemical binding]; other site
592021001982	EamA-like transporter family; Region: EamA; pfam00892
592021001983	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
592021001984	EamA-like transporter family; Region: EamA; pfam00892
592021001985	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
592021001986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021001987	DNA-binding site [nucleotide binding]; DNA binding site
592021001988	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021001989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021001990	homodimer interface [polypeptide binding]; other site
592021001991	catalytic residue [active]
592021001992	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
592021001993	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021001994	Coenzyme A binding pocket [chemical binding]; other site
592021001995	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021001996	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021001997	dimerization interface [polypeptide binding]; other site
592021001998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021001999	dimer interface [polypeptide binding]; other site
592021002000	phosphorylation site [posttranslational modification]
592021002001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021002002	ATP binding site [chemical binding]; other site
592021002003	Mg2+ binding site [ion binding]; other site
592021002004	G-X-G motif; other site
592021002005	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021002006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021002007	active site
592021002008	phosphorylation site [posttranslational modification]
592021002009	intermolecular recognition site; other site
592021002010	dimerization interface [polypeptide binding]; other site
592021002011	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021002012	DNA binding site [nucleotide binding]
592021002013	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
592021002014	Arrestin_N terminal like; Region: LDB19; pfam13002
592021002015	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021002016	Coenzyme A binding pocket [chemical binding]; other site
592021002017	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
592021002018	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
592021002019	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
592021002020	catalytic loop [active]
592021002021	iron binding site [ion binding]; other site
592021002022	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
592021002023	4Fe-4S binding domain; Region: Fer4; pfam00037
592021002024	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
592021002025	[4Fe-4S] binding site [ion binding]; other site
592021002026	molybdopterin cofactor binding site; other site
592021002027	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
592021002028	molybdopterin cofactor binding site; other site
592021002029	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
592021002030	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
592021002031	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
592021002032	putative active site [active]
592021002033	catalytic site [active]
592021002034	putative metal binding site [ion binding]; other site
592021002035	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
592021002036	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
592021002037	hexamer interface [polypeptide binding]; other site
592021002038	ligand binding site [chemical binding]; other site
592021002039	putative active site [active]
592021002040	NAD(P) binding site [chemical binding]; other site
592021002041	amino acid transporter; Region: 2A0306; TIGR00909
592021002042	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
592021002043	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021002044	dimerization interface [polypeptide binding]; other site
592021002045	putative DNA binding site [nucleotide binding]; other site
592021002046	putative Zn2+ binding site [ion binding]; other site
592021002047	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
592021002048	metal-binding site [ion binding]
592021002049	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
592021002050	Heavy-metal-associated domain; Region: HMA; pfam00403
592021002051	metal-binding site [ion binding]
592021002052	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
592021002053	Soluble P-type ATPase [General function prediction only]; Region: COG4087
592021002054	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
592021002055	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
592021002056	active site
592021002057	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021002058	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021002059	non-specific DNA binding site [nucleotide binding]; other site
592021002060	salt bridge; other site
592021002061	sequence-specific DNA binding site [nucleotide binding]; other site
592021002062	Tetratricopeptide repeat; Region: TPR_12; pfam13424
592021002063	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
592021002064	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
592021002065	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
592021002066	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
592021002067	active site
592021002068	Zn binding site [ion binding]; other site
592021002069	Uncharacterized conserved protein [Function unknown]; Region: COG0398
592021002070	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
592021002071	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
592021002072	VanW like protein; Region: VanW; pfam04294
592021002073	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
592021002074	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
592021002075	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
592021002076	Nucleoside recognition; Region: Gate; pfam07670
592021002077	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
592021002078	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
592021002079	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021002080	putative metal binding site [ion binding]; other site
592021002081	Domain of unknown function DUF21; Region: DUF21; pfam01595
592021002082	FOG: CBS domain [General function prediction only]; Region: COG0517
592021002083	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
592021002084	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
592021002085	Aspartase; Region: Aspartase; cd01357
592021002086	active sites [active]
592021002087	tetramer interface [polypeptide binding]; other site
592021002088	L-lactate permease; Region: Lactate_perm; cl00701
592021002089	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
592021002090	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021002091	dimerization interface [polypeptide binding]; other site
592021002092	putative Zn2+ binding site [ion binding]; other site
592021002093	putative DNA binding site [nucleotide binding]; other site
592021002094	acid-soluble spore protein H; Provisional; Region: sspH; PRK01625
592021002095	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
592021002096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002097	putative substrate translocation pore; other site
592021002098	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
592021002099	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
592021002100	siderophore binding site; other site
592021002101	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
592021002102	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021002103	ABC-ATPase subunit  interface; other site
592021002104	dimer interface [polypeptide binding]; other site
592021002105	putative PBP binding regions; other site
592021002106	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
592021002107	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021002108	ABC-ATPase subunit  interface; other site
592021002109	dimer interface [polypeptide binding]; other site
592021002110	putative PBP binding regions; other site
592021002111	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
592021002112	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
592021002113	Walker A/P-loop; other site
592021002114	ATP binding site [chemical binding]; other site
592021002115	Q-loop/lid; other site
592021002116	ABC transporter signature motif; other site
592021002117	Walker B; other site
592021002118	D-loop; other site
592021002119	H-loop/switch region; other site
592021002120	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021002121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021002122	S-adenosylmethionine binding site [chemical binding]; other site
592021002123	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
592021002124	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
592021002125	substrate-cofactor binding pocket; other site
592021002126	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021002127	catalytic residue [active]
592021002128	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
592021002129	nudix motif; other site
592021002130	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
592021002131	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
592021002132	metal ion-dependent adhesion site (MIDAS); other site
592021002133	MoxR-like ATPases [General function prediction only]; Region: COG0714
592021002134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021002135	Walker A motif; other site
592021002136	ATP binding site [chemical binding]; other site
592021002137	Walker B motif; other site
592021002138	arginine finger; other site
592021002139	cardiolipin synthetase; Reviewed; Region: PRK12452
592021002140	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
592021002141	putative active site [active]
592021002142	catalytic site [active]
592021002143	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
592021002144	putative active site [active]
592021002145	catalytic site [active]
592021002146	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021002147	PAS domain; Region: PAS_9; pfam13426
592021002148	putative active site [active]
592021002149	heme pocket [chemical binding]; other site
592021002150	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021002151	metal binding site [ion binding]; metal-binding site
592021002152	active site
592021002153	I-site; other site
592021002154	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
592021002155	Amino acid permease; Region: AA_permease_2; pfam13520
592021002156	Spore germination protein; Region: Spore_permease; cl17796
592021002157	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021002158	DNA-binding site [nucleotide binding]; DNA binding site
592021002159	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
592021002160	UTRA domain; Region: UTRA; pfam07702
592021002161	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
592021002162	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
592021002163	active site turn [active]
592021002164	phosphorylation site [posttranslational modification]
592021002165	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
592021002166	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
592021002167	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
592021002168	Ca binding site [ion binding]; other site
592021002169	active site
592021002170	catalytic site [active]
592021002171	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
592021002172	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
592021002173	Spore germination protein; Region: Spore_permease; cl17796
592021002174	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
592021002175	CAAX protease self-immunity; Region: Abi; pfam02517
592021002176	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
592021002177	active site
592021002178	ATP binding site [chemical binding]; other site
592021002179	substrate binding site [chemical binding]; other site
592021002180	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
592021002181	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
592021002182	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
592021002183	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
592021002184	Walker A/P-loop; other site
592021002185	ATP binding site [chemical binding]; other site
592021002186	Q-loop/lid; other site
592021002187	ABC transporter signature motif; other site
592021002188	Walker B; other site
592021002189	D-loop; other site
592021002190	H-loop/switch region; other site
592021002191	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
592021002192	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
592021002193	substrate binding pocket [chemical binding]; other site
592021002194	membrane-bound complex binding site; other site
592021002195	hinge residues; other site
592021002196	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
592021002197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002198	dimer interface [polypeptide binding]; other site
592021002199	conserved gate region; other site
592021002200	putative PBP binding loops; other site
592021002201	ABC-ATPase subunit interface; other site
592021002202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002203	dimer interface [polypeptide binding]; other site
592021002204	conserved gate region; other site
592021002205	putative PBP binding loops; other site
592021002206	ABC-ATPase subunit interface; other site
592021002207	S-methylmethionine transporter; Provisional; Region: PRK11387
592021002208	OsmC-like protein; Region: OsmC; pfam02566
592021002209	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
592021002210	nucleotide binding site/active site [active]
592021002211	HIT family signature motif; other site
592021002212	catalytic residue [active]
592021002213	RNA polymerase sigma factor; Provisional; Region: PRK12542
592021002214	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021002215	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021002216	DNA binding residues [nucleotide binding]
592021002217	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
592021002218	Predicted transcriptional regulator [Transcription]; Region: COG2378
592021002219	HTH domain; Region: HTH_11; pfam08279
592021002220	WYL domain; Region: WYL; pfam13280
592021002221	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
592021002222	RibD C-terminal domain; Region: RibD_C; cl17279
592021002223	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021002224	dimerization interface [polypeptide binding]; other site
592021002225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021002226	dimer interface [polypeptide binding]; other site
592021002227	phosphorylation site [posttranslational modification]
592021002228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021002229	ATP binding site [chemical binding]; other site
592021002230	Mg2+ binding site [ion binding]; other site
592021002231	G-X-G motif; other site
592021002232	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021002233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021002234	active site
592021002235	phosphorylation site [posttranslational modification]
592021002236	intermolecular recognition site; other site
592021002237	dimerization interface [polypeptide binding]; other site
592021002238	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021002239	DNA binding site [nucleotide binding]
592021002240	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
592021002241	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
592021002242	Sulfate transporter family; Region: Sulfate_transp; pfam00916
592021002243	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
592021002244	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
592021002245	Ligand Binding Site [chemical binding]; other site
592021002246	Protein of unknown function (DUF4027); Region: DUF4027; pfam13219
592021002247	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
592021002248	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
592021002249	peptide binding site [polypeptide binding]; other site
592021002250	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
592021002251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002252	dimer interface [polypeptide binding]; other site
592021002253	conserved gate region; other site
592021002254	putative PBP binding loops; other site
592021002255	ABC-ATPase subunit interface; other site
592021002256	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
592021002257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002258	putative PBP binding loops; other site
592021002259	ABC-ATPase subunit interface; other site
592021002260	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
592021002261	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021002262	Walker A/P-loop; other site
592021002263	ATP binding site [chemical binding]; other site
592021002264	Q-loop/lid; other site
592021002265	ABC transporter signature motif; other site
592021002266	Walker B; other site
592021002267	D-loop; other site
592021002268	H-loop/switch region; other site
592021002269	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
592021002270	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
592021002271	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021002272	Walker A/P-loop; other site
592021002273	ATP binding site [chemical binding]; other site
592021002274	Q-loop/lid; other site
592021002275	ABC transporter signature motif; other site
592021002276	Walker B; other site
592021002277	D-loop; other site
592021002278	H-loop/switch region; other site
592021002279	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
592021002280	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
592021002281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002282	putative substrate translocation pore; other site
592021002283	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021002284	MarR family; Region: MarR; pfam01047
592021002285	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021002286	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021002287	DNA binding site [nucleotide binding]
592021002288	domain linker motif; other site
592021002289	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
592021002290	dimerization interface [polypeptide binding]; other site
592021002291	ligand binding site [chemical binding]; other site
592021002292	sodium binding site [ion binding]; other site
592021002293	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
592021002294	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
592021002295	substrate binding site [chemical binding]; other site
592021002296	dimer interface [polypeptide binding]; other site
592021002297	ATP binding site [chemical binding]; other site
592021002298	D-ribose pyranase; Provisional; Region: PRK11797
592021002299	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
592021002300	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
592021002301	Walker A/P-loop; other site
592021002302	ATP binding site [chemical binding]; other site
592021002303	Q-loop/lid; other site
592021002304	ABC transporter signature motif; other site
592021002305	Walker B; other site
592021002306	D-loop; other site
592021002307	H-loop/switch region; other site
592021002308	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
592021002309	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
592021002310	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
592021002311	TM-ABC transporter signature motif; other site
592021002312	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
592021002313	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
592021002314	ligand binding site [chemical binding]; other site
592021002315	dimerization interface [polypeptide binding]; other site
592021002316	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
592021002317	active site
592021002318	intersubunit interactions; other site
592021002319	catalytic residue [active]
592021002320	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
592021002321	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
592021002322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002323	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021002324	putative substrate translocation pore; other site
592021002325	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
592021002326	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
592021002327	putative NAD(P) binding site [chemical binding]; other site
592021002328	catalytic Zn binding site [ion binding]; other site
592021002329	Ion channel; Region: Ion_trans_2; pfam07885
592021002330	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
592021002331	Zn binding site [ion binding]; other site
592021002332	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
592021002333	putative catalytic site [active]
592021002334	metal binding site A [ion binding]; metal-binding site
592021002335	phosphate binding site [ion binding]; other site
592021002336	metal binding site C [ion binding]; metal-binding site
592021002337	metal binding site B [ion binding]; metal-binding site
592021002338	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
592021002339	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
592021002340	dimer interface [polypeptide binding]; other site
592021002341	active site
592021002342	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
592021002343	substrate binding site [chemical binding]; other site
592021002344	catalytic residue [active]
592021002345	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
592021002346	FAD binding domain; Region: FAD_binding_4; pfam01565
592021002347	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
592021002348	VanZ like family; Region: VanZ; pfam04892
592021002349	RDD family; Region: RDD; pfam06271
592021002350	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
592021002351	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021002352	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021002353	dimer interface [polypeptide binding]; other site
592021002354	putative CheW interface [polypeptide binding]; other site
592021002355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
592021002356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
592021002357	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021002358	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021002359	non-specific DNA binding site [nucleotide binding]; other site
592021002360	salt bridge; other site
592021002361	sequence-specific DNA binding site [nucleotide binding]; other site
592021002362	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
592021002363	active site
592021002364	catalytic site [active]
592021002365	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
592021002366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002367	putative substrate translocation pore; other site
592021002368	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
592021002369	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943
592021002370	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
592021002371	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
592021002372	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
592021002373	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
592021002374	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021002375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021002376	non-specific DNA binding site [nucleotide binding]; other site
592021002377	salt bridge; other site
592021002378	sequence-specific DNA binding site [nucleotide binding]; other site
592021002379	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021002380	Coenzyme A binding pocket [chemical binding]; other site
592021002381	Protein of unknown function (DUF4022); Region: DUF4022; pfam13214
592021002382	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
592021002383	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
592021002384	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
592021002385	TrkA-N domain; Region: TrkA_N; pfam02254
592021002386	TrkA-C domain; Region: TrkA_C; pfam02080
592021002387	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
592021002388	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
592021002389	Subunit I/III interface [polypeptide binding]; other site
592021002390	Subunit III/IV interface [polypeptide binding]; other site
592021002391	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
592021002392	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
592021002393	D-pathway; other site
592021002394	Putative ubiquinol binding site [chemical binding]; other site
592021002395	Low-spin heme (heme b) binding site [chemical binding]; other site
592021002396	Putative water exit pathway; other site
592021002397	Binuclear center (heme o3/CuB) [ion binding]; other site
592021002398	K-pathway; other site
592021002399	Putative proton exit pathway; other site
592021002400	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
592021002401	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
592021002402	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
592021002403	putative active site [active]
592021002404	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
592021002405	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
592021002406	metal binding site [ion binding]; metal-binding site
592021002407	dimer interface [polypeptide binding]; other site
592021002408	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
592021002409	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
592021002410	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
592021002411	Na binding site [ion binding]; other site
592021002412	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
592021002413	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
592021002414	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
592021002415	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
592021002416	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
592021002417	Nucleoside recognition; Region: Gate; pfam07670
592021002418	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
592021002419	Nucleoside recognition; Region: Gate; pfam07670
592021002420	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
592021002421	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
592021002422	G1 box; other site
592021002423	GTP/Mg2+ binding site [chemical binding]; other site
592021002424	Switch I region; other site
592021002425	G2 box; other site
592021002426	G3 box; other site
592021002427	Switch II region; other site
592021002428	G4 box; other site
592021002429	G5 box; other site
592021002430	FeoA domain; Region: FeoA; pfam04023
592021002431	phosphate binding protein; Region: ptsS_2; TIGR02136
592021002432	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
592021002433	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
592021002434	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002435	dimer interface [polypeptide binding]; other site
592021002436	conserved gate region; other site
592021002437	putative PBP binding loops; other site
592021002438	ABC-ATPase subunit interface; other site
592021002439	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
592021002440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002441	dimer interface [polypeptide binding]; other site
592021002442	conserved gate region; other site
592021002443	putative PBP binding loops; other site
592021002444	ABC-ATPase subunit interface; other site
592021002445	AAA domain; Region: AAA_33; pfam13671
592021002446	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
592021002447	active site
592021002448	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
592021002449	FOG: CBS domain [General function prediction only]; Region: COG0517
592021002450	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
592021002451	Domain of unknown function (DUF3960); Region: DUF3960; pfam13142
592021002452	Protein of unknown function (DUF3965); Region: DUF3965; pfam13112
592021002453	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021002454	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021002455	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021002456	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
592021002457	Peptidase family M23; Region: Peptidase_M23; pfam01551
592021002458	Putative transcription activator [Transcription]; Region: TenA; COG0819
592021002459	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
592021002460	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
592021002461	Walker A/P-loop; other site
592021002462	ATP binding site [chemical binding]; other site
592021002463	Q-loop/lid; other site
592021002464	ABC transporter signature motif; other site
592021002465	Walker B; other site
592021002466	D-loop; other site
592021002467	H-loop/switch region; other site
592021002468	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
592021002469	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002470	dimer interface [polypeptide binding]; other site
592021002471	conserved gate region; other site
592021002472	putative PBP binding loops; other site
592021002473	ABC-ATPase subunit interface; other site
592021002474	NMT1/THI5 like; Region: NMT1; pfam09084
592021002475	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
592021002476	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
592021002477	thiamine phosphate binding site [chemical binding]; other site
592021002478	active site
592021002479	pyrophosphate binding site [ion binding]; other site
592021002480	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
592021002481	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
592021002482	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
592021002483	thiS-thiF/thiG interaction site; other site
592021002484	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
592021002485	ThiS interaction site; other site
592021002486	putative active site [active]
592021002487	tetramer interface [polypeptide binding]; other site
592021002488	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
592021002489	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
592021002490	ATP binding site [chemical binding]; other site
592021002491	substrate interface [chemical binding]; other site
592021002492	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
592021002493	dimer interface [polypeptide binding]; other site
592021002494	substrate binding site [chemical binding]; other site
592021002495	ATP binding site [chemical binding]; other site
592021002496	ydaO/yuaA leader
592021002497	ydaO/yuaA leader
592021002498	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
592021002499	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
592021002500	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
592021002501	Soluble P-type ATPase [General function prediction only]; Region: COG4087
592021002502	potassium-transporting ATPase subunit C; Provisional; Region: PRK13997
592021002503	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
592021002504	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
592021002505	Ligand Binding Site [chemical binding]; other site
592021002506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002507	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021002508	putative substrate translocation pore; other site
592021002509	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021002510	MarR family; Region: MarR; pfam01047
592021002511	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
592021002512	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
592021002513	active site
592021002514	nucleophile elbow; other site
592021002515	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
592021002516	short chain dehydrogenase; Provisional; Region: PRK06701
592021002517	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
592021002518	NAD binding site [chemical binding]; other site
592021002519	metal binding site [ion binding]; metal-binding site
592021002520	active site
592021002521	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
592021002522	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
592021002523	putative substrate binding site [chemical binding]; other site
592021002524	putative ATP binding site [chemical binding]; other site
592021002525	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
592021002526	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
592021002527	substrate binding [chemical binding]; other site
592021002528	active site
592021002529	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
592021002530	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
592021002531	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
592021002532	active site turn [active]
592021002533	phosphorylation site [posttranslational modification]
592021002534	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
592021002535	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021002536	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021002537	DNA binding site [nucleotide binding]
592021002538	domain linker motif; other site
592021002539	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
592021002540	dimerization interface [polypeptide binding]; other site
592021002541	ligand binding site [chemical binding]; other site
592021002542	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
592021002543	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
592021002544	catalytic residues [active]
592021002545	putative disulfide oxidoreductase; Provisional; Region: PRK03113
592021002546	YhdB-like protein; Region: YhdB; pfam14148
592021002547	Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798
592021002548	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
592021002549	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
592021002550	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
592021002551	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
592021002552	putative FMN binding site [chemical binding]; other site
592021002553	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
592021002554	SpoVR like protein; Region: SpoVR; pfam04293
592021002555	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
592021002556	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
592021002557	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021002558	putative DNA binding site [nucleotide binding]; other site
592021002559	putative Zn2+ binding site [ion binding]; other site
592021002560	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021002561	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
592021002562	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
592021002563	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
592021002564	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021002565	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
592021002566	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
592021002567	active site residue [active]
592021002568	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
592021002569	putative homodimer interface [polypeptide binding]; other site
592021002570	putative homotetramer interface [polypeptide binding]; other site
592021002571	putative metal binding site [ion binding]; other site
592021002572	putative homodimer-homodimer interface [polypeptide binding]; other site
592021002573	putative allosteric switch controlling residues; other site
592021002574	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
592021002575	CPxP  motif; other site
592021002576	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
592021002577	active site residue [active]
592021002578	Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523
592021002579	active site residue [active]
592021002580	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021002581	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
592021002582	CPxP  motif; other site
592021002583	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
592021002584	active site residue [active]
592021002585	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
592021002586	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
592021002587	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
592021002588	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
592021002589	NADP binding site [chemical binding]; other site
592021002590	dimer interface [polypeptide binding]; other site
592021002591	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
592021002592	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
592021002593	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
592021002594	PhoU domain; Region: PhoU; pfam01895
592021002595	PhoU domain; Region: PhoU; pfam01895
592021002596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002597	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021002598	putative substrate translocation pore; other site
592021002599	Uncharacterized conserved protein [Function unknown]; Region: COG3589
592021002600	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
592021002601	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
592021002602	HTH domain; Region: HTH_11; pfam08279
592021002603	Mga helix-turn-helix domain; Region: Mga; pfam05043
592021002604	PRD domain; Region: PRD; pfam00874
592021002605	PRD domain; Region: PRD; pfam00874
592021002606	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
592021002607	active site
592021002608	P-loop; other site
592021002609	phosphorylation site [posttranslational modification]
592021002610	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
592021002611	active site
592021002612	phosphorylation site [posttranslational modification]
592021002613	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
592021002614	active site
592021002615	methionine cluster; other site
592021002616	phosphorylation site [posttranslational modification]
592021002617	metal binding site [ion binding]; metal-binding site
592021002618	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
592021002619	active site
592021002620	P-loop; other site
592021002621	phosphorylation site [posttranslational modification]
592021002622	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
592021002623	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
592021002624	Uncharacterized conserved protein [Function unknown]; Region: COG3589
592021002625	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
592021002626	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021002627	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021002628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
592021002629	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
592021002630	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
592021002631	FtsX-like permease family; Region: FtsX; pfam02687
592021002632	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021002633	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021002634	Walker A/P-loop; other site
592021002635	ATP binding site [chemical binding]; other site
592021002636	Q-loop/lid; other site
592021002637	ABC transporter signature motif; other site
592021002638	Walker B; other site
592021002639	D-loop; other site
592021002640	H-loop/switch region; other site
592021002641	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
592021002642	HlyD family secretion protein; Region: HlyD_3; pfam13437
592021002643	conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381
592021002644	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
592021002645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002646	dimer interface [polypeptide binding]; other site
592021002647	conserved gate region; other site
592021002648	ABC-ATPase subunit interface; other site
592021002649	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
592021002650	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
592021002651	dimanganese center [ion binding]; other site
592021002652	CotJB protein; Region: CotJB; pfam12652
592021002653	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
592021002654	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021002655	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
592021002656	active site
592021002657	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
592021002658	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
592021002659	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
592021002660	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
592021002661	putative DNA binding site [nucleotide binding]; other site
592021002662	putative homodimer interface [polypeptide binding]; other site
592021002663	yybP-ykoY leader
592021002664	Uncharacterized conserved protein [Function unknown]; Region: COG3339
592021002665	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
592021002666	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
592021002667	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
592021002668	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
592021002669	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
592021002670	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
592021002671	active site
592021002672	metal binding site [ion binding]; metal-binding site
592021002673	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
592021002674	Interdomain contacts; other site
592021002675	Cytokine receptor motif; other site
592021002676	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
592021002677	amino acid transporter; Region: 2A0306; TIGR00909
592021002678	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
592021002679	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
592021002680	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
592021002681	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
592021002682	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
592021002683	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
592021002684	putative active site [active]
592021002685	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
592021002686	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
592021002687	putative active site [active]
592021002688	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
592021002689	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
592021002690	active site turn [active]
592021002691	phosphorylation site [posttranslational modification]
592021002692	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
592021002693	Uncharacterized conserved protein [Function unknown]; Region: COG3589
592021002694	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
592021002695	DoxX; Region: DoxX; pfam07681
592021002696	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
592021002697	hypothetical protein; Provisional; Region: PRK06770
592021002698	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021002699	EamA-like transporter family; Region: EamA; pfam00892
592021002700	EamA-like transporter family; Region: EamA; pfam00892
592021002701	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
592021002702	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
592021002703	AsnC family; Region: AsnC_trans_reg; pfam01037
592021002704	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021002705	Coenzyme A binding pocket [chemical binding]; other site
592021002706	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
592021002707	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
592021002708	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021002709	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021002710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002711	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021002712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002713	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021002714	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021002715	putative DNA binding site [nucleotide binding]; other site
592021002716	putative Zn2+ binding site [ion binding]; other site
592021002717	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
592021002718	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
592021002719	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
592021002720	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
592021002721	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
592021002722	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
592021002723	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021002724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002725	putative substrate translocation pore; other site
592021002726	intracellular protease, PfpI family; Region: PfpI; TIGR01382
592021002727	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
592021002728	proposed catalytic triad [active]
592021002729	conserved cys residue [active]
592021002730	hydroperoxidase II; Provisional; Region: katE; PRK11249
592021002731	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
592021002732	tetramer interface [polypeptide binding]; other site
592021002733	heme binding pocket [chemical binding]; other site
592021002734	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
592021002735	domain interactions; other site
592021002736	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
592021002737	arginine:agmatin antiporter; Provisional; Region: PRK10644
592021002738	Spore germination protein; Region: Spore_permease; cl17796
592021002739	glutamate racemase; Provisional; Region: PRK00865
592021002740	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
592021002741	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
592021002742	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
592021002743	tetrameric interface [polypeptide binding]; other site
592021002744	activator binding site; other site
592021002745	NADP binding site [chemical binding]; other site
592021002746	substrate binding site [chemical binding]; other site
592021002747	catalytic residues [active]
592021002748	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021002749	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
592021002750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021002751	Walker A/P-loop; other site
592021002752	ATP binding site [chemical binding]; other site
592021002753	Q-loop/lid; other site
592021002754	ABC transporter signature motif; other site
592021002755	Walker B; other site
592021002756	D-loop; other site
592021002757	H-loop/switch region; other site
592021002758	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
592021002759	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
592021002760	substrate binding pocket [chemical binding]; other site
592021002761	membrane-bound complex binding site; other site
592021002762	hinge residues; other site
592021002763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002764	dimer interface [polypeptide binding]; other site
592021002765	conserved gate region; other site
592021002766	putative PBP binding loops; other site
592021002767	ABC-ATPase subunit interface; other site
592021002768	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
592021002769	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
592021002770	Walker A/P-loop; other site
592021002771	ATP binding site [chemical binding]; other site
592021002772	Q-loop/lid; other site
592021002773	ABC transporter signature motif; other site
592021002774	Walker B; other site
592021002775	D-loop; other site
592021002776	H-loop/switch region; other site
592021002777	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
592021002778	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
592021002779	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
592021002780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
592021002781	hypothetical protein; Provisional; Region: PRK13676
592021002782	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
592021002783	acetolactate synthase; Reviewed; Region: PRK08617
592021002784	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
592021002785	PYR/PP interface [polypeptide binding]; other site
592021002786	dimer interface [polypeptide binding]; other site
592021002787	TPP binding site [chemical binding]; other site
592021002788	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
592021002789	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
592021002790	TPP-binding site [chemical binding]; other site
592021002791	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
592021002792	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
592021002793	active site
592021002794	DNA binding site [nucleotide binding]
592021002795	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
592021002796	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021002797	active site
592021002798	motif I; other site
592021002799	motif II; other site
592021002800	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021002801	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
592021002802	Cna protein B-type domain; Region: Cna_B; pfam05738
592021002803	Cna protein B-type domain; Region: Cna_B; pfam05738
592021002804	Cna protein B-type domain; Region: Cna_B; pfam05738
592021002805	Cna protein B-type domain; Region: Cna_B; pfam05738
592021002806	Cna protein B-type domain; Region: Cna_B; pfam05738
592021002807	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
592021002808	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
592021002809	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
592021002810	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
592021002811	acyl-activating enzyme (AAE) consensus motif; other site
592021002812	acyl-activating enzyme (AAE) consensus motif; other site
592021002813	putative AMP binding site [chemical binding]; other site
592021002814	putative active site [active]
592021002815	putative CoA binding site [chemical binding]; other site
592021002816	high affinity sulphate transporter 1; Region: sulP; TIGR00815
592021002817	Sulfate transporter family; Region: Sulfate_transp; pfam00916
592021002818	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
592021002819	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
592021002820	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
592021002821	ATP binding site [chemical binding]; other site
592021002822	putative Mg++ binding site [ion binding]; other site
592021002823	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
592021002824	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021002825	nucleotide binding region [chemical binding]; other site
592021002826	ATP-binding site [chemical binding]; other site
592021002827	stage V sporulation protein B; Region: spore_V_B; TIGR02900
592021002828	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
592021002829	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
592021002830	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
592021002831	S-layer homology domain; Region: SLH; pfam00395
592021002832	S-layer homology domain; Region: SLH; pfam00395
592021002833	S-layer homology domain; Region: SLH; pfam00395
592021002834	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
592021002835	S-layer homology domain; Region: SLH; pfam00395
592021002836	S-layer homology domain; Region: SLH; pfam00395
592021002837	S-layer homology domain; Region: SLH; pfam00395
592021002838	DHHW protein; Region: DHHW; pfam14286
592021002839	DHHW protein; Region: DHHW; pfam14286
592021002840	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
592021002841	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
592021002842	enoyl-CoA hydratase; Provisional; Region: PRK07659
592021002843	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
592021002844	substrate binding site [chemical binding]; other site
592021002845	oxyanion hole (OAH) forming residues; other site
592021002846	trimer interface [polypeptide binding]; other site
592021002847	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
592021002848	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
592021002849	putative oligomer interface [polypeptide binding]; other site
592021002850	putative active site [active]
592021002851	metal binding site [ion binding]; metal-binding site
592021002852	S-layer homology domain; Region: SLH; pfam00395
592021002853	S-layer homology domain; Region: SLH; pfam00395
592021002854	S-layer homology domain; Region: SLH; pfam00395
592021002855	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
592021002856	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
592021002857	active site
592021002858	metal binding site [ion binding]; metal-binding site
592021002859	Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041
592021002860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021002861	S-adenosylmethionine binding site [chemical binding]; other site
592021002862	proline racemase; Provisional; Region: PRK13969
592021002863	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
592021002864	ornithine cyclodeaminase; Validated; Region: PRK08618
592021002865	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
592021002866	NAD(P) binding site [chemical binding]; other site
592021002867	Yip1 domain; Region: Yip1; pfam04893
592021002868	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
592021002869	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
592021002870	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
592021002871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002872	dimer interface [polypeptide binding]; other site
592021002873	conserved gate region; other site
592021002874	putative PBP binding loops; other site
592021002875	ABC-ATPase subunit interface; other site
592021002876	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
592021002877	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
592021002878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021002879	dimer interface [polypeptide binding]; other site
592021002880	conserved gate region; other site
592021002881	putative PBP binding loops; other site
592021002882	ABC-ATPase subunit interface; other site
592021002883	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
592021002884	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021002885	Walker A/P-loop; other site
592021002886	ATP binding site [chemical binding]; other site
592021002887	Q-loop/lid; other site
592021002888	ABC transporter signature motif; other site
592021002889	Walker B; other site
592021002890	D-loop; other site
592021002891	H-loop/switch region; other site
592021002892	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
592021002893	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
592021002894	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
592021002895	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
592021002896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002897	putative substrate translocation pore; other site
592021002898	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
592021002899	PAS domain; Region: PAS; smart00091
592021002900	putative active site [active]
592021002901	heme pocket [chemical binding]; other site
592021002902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021002903	ATP binding site [chemical binding]; other site
592021002904	Mg2+ binding site [ion binding]; other site
592021002905	G-X-G motif; other site
592021002906	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
592021002907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021002908	active site
592021002909	phosphorylation site [posttranslational modification]
592021002910	intermolecular recognition site; other site
592021002911	dimerization interface [polypeptide binding]; other site
592021002912	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
592021002913	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
592021002914	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
592021002915	putative metal binding site [ion binding]; other site
592021002916	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
592021002917	putative metal binding site [ion binding]; other site
592021002918	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
592021002919	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
592021002920	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
592021002921	Protein of unknown function (DUF524); Region: DUF524; pfam04411
592021002922	Tic20-like protein; Region: Tic20; pfam09685
592021002923	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
592021002924	DNA binding residues [nucleotide binding]
592021002925	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
592021002926	dimer interface [polypeptide binding]; other site
592021002927	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
592021002928	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
592021002929	metal binding site [ion binding]; metal-binding site
592021002930	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
592021002931	replicative DNA helicase; Provisional; Region: PRK06749
592021002932	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
592021002933	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
592021002934	Walker A motif; other site
592021002935	ATP binding site [chemical binding]; other site
592021002936	Walker B motif; other site
592021002937	DNA binding loops [nucleotide binding]
592021002938	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
592021002939	Predicted transcriptional regulators [Transcription]; Region: COG1378
592021002940	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
592021002941	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
592021002942	C-terminal domain interface [polypeptide binding]; other site
592021002943	sugar binding site [chemical binding]; other site
592021002944	hypothetical protein; Provisional; Region: PRK10621
592021002945	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
592021002946	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021002947	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021002948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002949	putative substrate translocation pore; other site
592021002950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021002951	Predicted permease; Region: DUF318; cl17795
592021002952	Predicted permeases [General function prediction only]; Region: COG0701
592021002953	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021002954	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
592021002955	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
592021002956	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
592021002957	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
592021002958	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
592021002959	CGNR zinc finger; Region: zf-CGNR; pfam11706
592021002960	HPP family; Region: HPP; pfam04982
592021002961	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
592021002962	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
592021002963	putative NAD(P) binding site [chemical binding]; other site
592021002964	active site
592021002965	putative substrate binding site [chemical binding]; other site
592021002966	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021002967	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021002968	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021002969	YmzC-like protein; Region: YmzC; pfam14157
592021002970	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
592021002971	Transcriptional regulators [Transcription]; Region: MarR; COG1846
592021002972	MarR family; Region: MarR_2; pfam12802
592021002973	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
592021002974	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
592021002975	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
592021002976	ATP synthase I chain; Region: ATP_synt_I; pfam03899
592021002977	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
592021002978	VanZ like family; Region: VanZ; pfam04892
592021002979	DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483
592021002980	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
592021002981	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
592021002982	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021002983	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
592021002984	dihydroxyacetone kinase; Provisional; Region: PRK14479
592021002985	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
592021002986	DAK2 domain; Region: Dak2; pfam02734
592021002987	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
592021002988	Predicted transcriptional regulator [Transcription]; Region: COG1959
592021002989	Transcriptional regulator; Region: Rrf2; pfam02082
592021002990	CAAX protease self-immunity; Region: Abi; pfam02517
592021002991	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
592021002992	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021002993	Zn2+ binding site [ion binding]; other site
592021002994	Mg2+ binding site [ion binding]; other site
592021002995	S-layer homology domain; Region: SLH; pfam00395
592021002996	S-layer homology domain; Region: SLH; pfam00395
592021002997	S-layer homology domain; Region: SLH; pfam00395
592021002998	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
592021002999	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021003000	Transcriptional regulator PadR-like family; Region: PadR; cl17335
592021003001	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
592021003002	Heat induced stress protein YflT; Region: YflT; pfam11181
592021003003	CsbD-like; Region: CsbD; pfam05532
592021003004	Predicted membrane protein [Function unknown]; Region: COG2261
592021003005	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
592021003006	anti sigma factor interaction site; other site
592021003007	regulatory phosphorylation site [posttranslational modification]; other site
592021003008	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
592021003009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021003010	ATP binding site [chemical binding]; other site
592021003011	Mg2+ binding site [ion binding]; other site
592021003012	G-X-G motif; other site
592021003013	RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941
592021003014	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021003015	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
592021003016	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021003017	DNA binding residues [nucleotide binding]
592021003018	Ferritin-like domain; Region: Ferritin; pfam00210
592021003019	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
592021003020	dinuclear metal binding motif [ion binding]; other site
592021003021	Response regulator receiver domain; Region: Response_reg; pfam00072
592021003022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021003023	active site
592021003024	phosphorylation site [posttranslational modification]
592021003025	intermolecular recognition site; other site
592021003026	dimerization interface [polypeptide binding]; other site
592021003027	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
592021003028	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
592021003029	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
592021003030	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
592021003031	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
592021003032	CHASE3 domain; Region: CHASE3; pfam05227
592021003033	GAF domain; Region: GAF; pfam01590
592021003034	GAF domain; Region: GAF_2; pfam13185
592021003035	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021003036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021003037	dimer interface [polypeptide binding]; other site
592021003038	phosphorylation site [posttranslational modification]
592021003039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021003040	ATP binding site [chemical binding]; other site
592021003041	Mg2+ binding site [ion binding]; other site
592021003042	G-X-G motif; other site
592021003043	Response regulator receiver domain; Region: Response_reg; pfam00072
592021003044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021003045	active site
592021003046	phosphorylation site [posttranslational modification]
592021003047	intermolecular recognition site; other site
592021003048	dimerization interface [polypeptide binding]; other site
592021003049	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
592021003050	Protein of unknown function (DUF4028); Region: DUF4028; pfam13220
592021003051	hypothetical protein; Provisional; Region: PRK12856
592021003052	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
592021003053	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
592021003054	NADP binding site [chemical binding]; other site
592021003055	dimer interface [polypeptide binding]; other site
592021003056	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
592021003057	YhzD-like protein; Region: YhzD; pfam14120
592021003058	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
592021003059	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
592021003060	active site
592021003061	metal binding site [ion binding]; metal-binding site
592021003062	DNA binding site [nucleotide binding]
592021003063	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
592021003064	AAA domain; Region: AAA_27; pfam13514
592021003065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
592021003066	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
592021003067	Probable transposase; Region: OrfB_IS605; pfam01385
592021003068	AAA domain; Region: AAA_27; pfam13514
592021003069	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021003070	Q-loop/lid; other site
592021003071	ABC transporter signature motif; other site
592021003072	Walker B; other site
592021003073	D-loop; other site
592021003074	H-loop/switch region; other site
592021003075	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
592021003076	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
592021003077	generic binding surface II; other site
592021003078	generic binding surface I; other site
592021003079	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021003080	Zn2+ binding site [ion binding]; other site
592021003081	Mg2+ binding site [ion binding]; other site
592021003082	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021003083	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021003084	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
592021003085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021003086	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
592021003087	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021003088	Zn binding site [ion binding]; other site
592021003089	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
592021003090	Zn binding site [ion binding]; other site
592021003091	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
592021003092	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021003093	Zn binding site [ion binding]; other site
592021003094	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
592021003095	Zn binding site [ion binding]; other site
592021003096	Tetratricopeptide repeat; Region: TPR_12; pfam13424
592021003097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021003098	TPR motif; other site
592021003099	binding surface
592021003100	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021003101	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
592021003102	Sporulation protein YhaL; Region: Spore_YhaL; pfam14147
592021003103	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
592021003104	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
592021003105	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021003106	non-specific DNA binding site [nucleotide binding]; other site
592021003107	salt bridge; other site
592021003108	sequence-specific DNA binding site [nucleotide binding]; other site
592021003109	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
592021003110	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
592021003111	amphipathic channel; other site
592021003112	Asn-Pro-Ala signature motifs; other site
592021003113	glycerol kinase; Provisional; Region: glpK; PRK00047
592021003114	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
592021003115	N- and C-terminal domain interface [polypeptide binding]; other site
592021003116	active site
592021003117	MgATP binding site [chemical binding]; other site
592021003118	catalytic site [active]
592021003119	metal binding site [ion binding]; metal-binding site
592021003120	glycerol binding site [chemical binding]; other site
592021003121	homotetramer interface [polypeptide binding]; other site
592021003122	homodimer interface [polypeptide binding]; other site
592021003123	FBP binding site [chemical binding]; other site
592021003124	protein IIAGlc interface [polypeptide binding]; other site
592021003125	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
592021003126	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
592021003127	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
592021003128	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021003129	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021003130	DNA binding residues [nucleotide binding]
592021003131	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
592021003132	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021003133	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
592021003134	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021003135	MarR family; Region: MarR; pfam01047
592021003136	DoxX-like family; Region: DoxX_2; pfam13564
592021003137	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
592021003138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021003139	putative substrate translocation pore; other site
592021003140	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
592021003141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021003142	putative substrate translocation pore; other site
592021003143	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
592021003144	Part of AAA domain; Region: AAA_19; pfam13245
592021003145	Family description; Region: UvrD_C_2; pfam13538
592021003146	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
592021003147	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
592021003148	Protein of unknown function (DUF1878); Region: DUF1878; pfam08963
592021003149	transcriptional regulator Hpr; Provisional; Region: PRK13777
592021003150	MarR family; Region: MarR; pfam01047
592021003151	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
592021003152	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
592021003153	HIT family signature motif; other site
592021003154	catalytic residue [active]
592021003155	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
592021003156	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021003157	Walker A/P-loop; other site
592021003158	ATP binding site [chemical binding]; other site
592021003159	Q-loop/lid; other site
592021003160	ABC transporter signature motif; other site
592021003161	Walker B; other site
592021003162	D-loop; other site
592021003163	H-loop/switch region; other site
592021003164	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
592021003165	EcsC protein family; Region: EcsC; pfam12787
592021003166	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021003167	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021003168	Uncharacterized conserved protein [Function unknown]; Region: COG3402
592021003169	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
592021003170	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
592021003171	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
592021003172	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021003173	DNA binding residues [nucleotide binding]
592021003174	drug binding residues [chemical binding]; other site
592021003175	dimer interface [polypeptide binding]; other site
592021003176	Uncharacterized conserved protein [Function unknown]; Region: COG3402
592021003177	Bacterial PH domain; Region: DUF304; pfam03703
592021003178	Bacterial PH domain; Region: DUF304; pfam03703
592021003179	Bacterial PH domain; Region: DUF304; pfam03703
592021003180	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
592021003181	Transglycosylase; Region: Transgly; pfam00912
592021003182	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
592021003183	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021003184	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
592021003185	substrate binding site [chemical binding]; other site
592021003186	active site
592021003187	ferrochelatase; Provisional; Region: PRK12435
592021003188	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
592021003189	C-terminal domain interface [polypeptide binding]; other site
592021003190	active site
592021003191	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
592021003192	active site
592021003193	N-terminal domain interface [polypeptide binding]; other site
592021003194	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
592021003195	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021003196	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021003197	Protein of unknown function (DUF4026); Region: DUF4026; pfam13218
592021003198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
592021003199	Fn3 associated; Region: Fn3_assoc; pfam13287
592021003200	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
592021003201	generic binding surface II; other site
592021003202	generic binding surface I; other site
592021003203	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
592021003204	putative active site [active]
592021003205	putative catalytic site [active]
592021003206	putative Mg binding site IVb [ion binding]; other site
592021003207	putative phosphate binding site [ion binding]; other site
592021003208	putative DNA binding site [nucleotide binding]; other site
592021003209	putative Mg binding site IVa [ion binding]; other site
592021003210	Penicillinase repressor; Region: Pencillinase_R; pfam03965
592021003211	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
592021003212	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021003213	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021003214	Predicted membrane protein [Function unknown]; Region: COG1511
592021003215	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
592021003216	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
592021003217	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
592021003218	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
592021003219	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
592021003220	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021003221	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021003222	Coenzyme A binding pocket [chemical binding]; other site
592021003223	YhfH-like protein; Region: YhfH; pfam14149
592021003224	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
592021003225	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
592021003226	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
592021003227	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
592021003228	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462
592021003229	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
592021003230	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
592021003231	acyl-activating enzyme (AAE) consensus motif; other site
592021003232	putative AMP binding site [chemical binding]; other site
592021003233	putative active site [active]
592021003234	putative CoA binding site [chemical binding]; other site
592021003235	rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150
592021003236	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
592021003237	heme-binding site [chemical binding]; other site
592021003238	S-layer homology domain; Region: SLH; pfam00395
592021003239	S-layer homology domain; Region: SLH; pfam00395
592021003240	S-layer homology domain; Region: SLH; pfam00395
592021003241	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
592021003242	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
592021003243	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
592021003244	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
592021003245	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
592021003246	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
592021003247	Aureocin-like type II bacteriocin; Region: Bacteriocin_IIi; pfam11758
592021003248	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
592021003249	RHS protein; Region: RHS; pfam03527
592021003250	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
592021003251	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
592021003252	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021003253	Zn2+ binding site [ion binding]; other site
592021003254	Mg2+ binding site [ion binding]; other site
592021003255	Putative zinc-finger; Region: zf-HC2; pfam13490
592021003256	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
592021003257	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
592021003258	RNA polymerase sigma factor; Provisional; Region: PRK12541
592021003259	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021003260	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021003261	DNA binding residues [nucleotide binding]
592021003262	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021003263	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
592021003264	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021003265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
592021003266	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021003267	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
592021003268	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021003269	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021003270	dimer interface [polypeptide binding]; other site
592021003271	phosphorylation site [posttranslational modification]
592021003272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021003273	ATP binding site [chemical binding]; other site
592021003274	Mg2+ binding site [ion binding]; other site
592021003275	G-X-G motif; other site
592021003276	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021003277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021003278	active site
592021003279	phosphorylation site [posttranslational modification]
592021003280	intermolecular recognition site; other site
592021003281	dimerization interface [polypeptide binding]; other site
592021003282	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021003283	DNA binding site [nucleotide binding]
592021003284	CAAX protease self-immunity; Region: Abi; pfam02517
592021003285	Peptidase family M48; Region: Peptidase_M48; pfam01435
592021003286	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
592021003287	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021003288	dimerization interface [polypeptide binding]; other site
592021003289	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021003290	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021003291	dimer interface [polypeptide binding]; other site
592021003292	putative CheW interface [polypeptide binding]; other site
592021003293	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
592021003294	EamA-like transporter family; Region: EamA; pfam00892
592021003295	EamA-like transporter family; Region: EamA; pfam00892
592021003296	S-layer homology domain; Region: SLH; pfam00395
592021003297	S-layer homology domain; Region: SLH; pfam00395
592021003298	S-layer homology domain; Region: SLH; pfam00395
592021003299	S-layer homology domain; Region: SLH; pfam00395
592021003300	S-layer homology domain; Region: SLH; pfam00395
592021003301	S-layer homology domain; Region: SLH; pfam00395
592021003302	S-layer homology domain; Region: SLH; pfam00395
592021003303	S-layer homology domain; Region: SLH; pfam00395
592021003304	S-layer homology domain; Region: SLH; pfam00395
592021003305	malate synthase A; Region: malate_syn_A; TIGR01344
592021003306	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
592021003307	active site
592021003308	isocitrate lyase; Provisional; Region: PRK15063
592021003309	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
592021003310	tetramer interface [polypeptide binding]; other site
592021003311	active site
592021003312	Mg2+/Mn2+ binding site [ion binding]; other site
592021003313	Phosphotransferase enzyme family; Region: APH; pfam01636
592021003314	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
592021003315	active site
592021003316	substrate binding site [chemical binding]; other site
592021003317	ATP binding site [chemical binding]; other site
592021003318	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
592021003319	DNA-binding site [nucleotide binding]; DNA binding site
592021003320	RNA-binding motif; other site
592021003321	ComK protein; Region: ComK; pfam06338
592021003322	Uncharacterized conserved protein [Function unknown]; Region: COG0398
592021003323	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
592021003324	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
592021003325	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
592021003326	Catalytic site [active]
592021003327	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
592021003328	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
592021003329	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
592021003330	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
592021003331	Part of AAA domain; Region: AAA_19; pfam13245
592021003332	Family description; Region: UvrD_C_2; pfam13538
592021003333	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
592021003334	hypothetical protein; Provisional; Region: PRK07758
592021003335	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
592021003336	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
592021003337	Spore germination protein GerPC; Region: GerPC; pfam10737
592021003338	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
592021003339	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
592021003340	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
592021003341	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
592021003342	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
592021003343	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021003344	inhibitor-cofactor binding pocket; inhibition site
592021003345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021003346	catalytic residue [active]
592021003347	hypothetical protein; Provisional; Region: PRK13673
592021003348	Protein of unknown function (DUF2777); Region: DUF2777; pfam10949
592021003349	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
592021003350	active site
592021003351	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
592021003352	dimer interface [polypeptide binding]; other site
592021003353	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
592021003354	Ligand Binding Site [chemical binding]; other site
592021003355	Molecular Tunnel; other site
592021003356	ferrochelatase; Provisional; Region: PRK12435
592021003357	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
592021003358	C-terminal domain interface [polypeptide binding]; other site
592021003359	active site
592021003360	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
592021003361	active site
592021003362	N-terminal domain interface [polypeptide binding]; other site
592021003363	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
592021003364	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
592021003365	tetramer interface [polypeptide binding]; other site
592021003366	heme binding pocket [chemical binding]; other site
592021003367	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
592021003368	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
592021003369	active site
592021003370	catalytic site [active]
592021003371	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021003372	non-specific DNA binding site [nucleotide binding]; other site
592021003373	salt bridge; other site
592021003374	sequence-specific DNA binding site [nucleotide binding]; other site
592021003375	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
592021003376	binding surface
592021003377	TPR motif; other site
592021003378	Tetratricopeptide repeat; Region: TPR_12; pfam13424
592021003379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
592021003380	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
592021003381	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
592021003382	S1 domain; Region: S1_2; pfam13509
592021003383	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
592021003384	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
592021003385	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021003386	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021003387	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021003388	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021003389	Protein of unknown function (DUF3813); Region: DUF3813; pfam12758
592021003390	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021003391	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021003392	active site
592021003393	motif I; other site
592021003394	motif II; other site
592021003395	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
592021003396	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
592021003397	Clp amino terminal domain; Region: Clp_N; pfam02861
592021003398	Clp amino terminal domain; Region: Clp_N; pfam02861
592021003399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021003400	Walker A motif; other site
592021003401	ATP binding site [chemical binding]; other site
592021003402	Walker B motif; other site
592021003403	arginine finger; other site
592021003404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021003405	Walker A motif; other site
592021003406	ATP binding site [chemical binding]; other site
592021003407	Walker B motif; other site
592021003408	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
592021003409	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
592021003410	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
592021003411	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
592021003412	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
592021003413	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
592021003414	NAD(P) binding site [chemical binding]; other site
592021003415	active site
592021003416	ComZ; Region: ComZ; pfam10815
592021003417	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
592021003418	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
592021003419	dimer interface [polypeptide binding]; other site
592021003420	active site
592021003421	CoA binding pocket [chemical binding]; other site
592021003422	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
592021003423	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
592021003424	dimer interface [polypeptide binding]; other site
592021003425	active site
592021003426	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
592021003427	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
592021003428	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
592021003429	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
592021003430	active site
592021003431	HIGH motif; other site
592021003432	dimer interface [polypeptide binding]; other site
592021003433	KMSKS motif; other site
592021003434	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
592021003435	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021003436	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021003437	peptide binding site [polypeptide binding]; other site
592021003438	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
592021003439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021003440	dimer interface [polypeptide binding]; other site
592021003441	conserved gate region; other site
592021003442	putative PBP binding loops; other site
592021003443	ABC-ATPase subunit interface; other site
592021003444	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
592021003445	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
592021003446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021003447	dimer interface [polypeptide binding]; other site
592021003448	conserved gate region; other site
592021003449	putative PBP binding loops; other site
592021003450	ABC-ATPase subunit interface; other site
592021003451	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
592021003452	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021003453	Walker A/P-loop; other site
592021003454	ATP binding site [chemical binding]; other site
592021003455	Q-loop/lid; other site
592021003456	ABC transporter signature motif; other site
592021003457	Walker B; other site
592021003458	D-loop; other site
592021003459	H-loop/switch region; other site
592021003460	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
592021003461	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
592021003462	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021003463	Walker A/P-loop; other site
592021003464	ATP binding site [chemical binding]; other site
592021003465	Q-loop/lid; other site
592021003466	ABC transporter signature motif; other site
592021003467	Walker B; other site
592021003468	D-loop; other site
592021003469	H-loop/switch region; other site
592021003470	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
592021003471	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
592021003472	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
592021003473	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021003474	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021003475	peptide binding site [polypeptide binding]; other site
592021003476	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
592021003477	ArsC family; Region: ArsC; pfam03960
592021003478	putative catalytic residues [active]
592021003479	thiol/disulfide switch; other site
592021003480	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
592021003481	adaptor protein; Provisional; Region: PRK02315
592021003482	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
592021003483	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
592021003484	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
592021003485	putative active site [active]
592021003486	catalytic site [active]
592021003487	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
592021003488	putative active site [active]
592021003489	catalytic site [active]
592021003490	Competence protein CoiA-like family; Region: CoiA; cl11541
592021003491	oligoendopeptidase F; Region: pepF; TIGR00181
592021003492	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
592021003493	active site
592021003494	Zn binding site [ion binding]; other site
592021003495	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
592021003496	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
592021003497	catalytic residues [active]
592021003498	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
592021003499	apolar tunnel; other site
592021003500	heme binding site [chemical binding]; other site
592021003501	dimerization interface [polypeptide binding]; other site
592021003502	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
592021003503	putative active site [active]
592021003504	putative metal binding residues [ion binding]; other site
592021003505	signature motif; other site
592021003506	putative triphosphate binding site [ion binding]; other site
592021003507	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
592021003508	synthetase active site [active]
592021003509	NTP binding site [chemical binding]; other site
592021003510	metal binding site [ion binding]; metal-binding site
592021003511	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
592021003512	ATP-NAD kinase; Region: NAD_kinase; pfam01513
592021003513	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
592021003514	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
592021003515	active site
592021003516	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
592021003517	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
592021003518	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
592021003519	active site
592021003520	metal binding site [ion binding]; metal-binding site
592021003521	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
592021003522	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
592021003523	active site
592021003524	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021003525	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021003526	S-adenosylmethionine binding site [chemical binding]; other site
592021003527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
592021003528	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
592021003529	putative metal binding site; other site
592021003530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021003531	binding surface
592021003532	TPR motif; other site
592021003533	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021003534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021003535	S-adenosylmethionine binding site [chemical binding]; other site
592021003536	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
592021003537	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
592021003538	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021003539	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
592021003540	active site
592021003541	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
592021003542	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
592021003543	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
592021003544	NAD binding site [chemical binding]; other site
592021003545	substrate binding site [chemical binding]; other site
592021003546	homodimer interface [polypeptide binding]; other site
592021003547	active site
592021003548	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
592021003549	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
592021003550	NADP binding site [chemical binding]; other site
592021003551	active site
592021003552	putative substrate binding site [chemical binding]; other site
592021003553	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
592021003554	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
592021003555	NAD binding site [chemical binding]; other site
592021003556	homotetramer interface [polypeptide binding]; other site
592021003557	homodimer interface [polypeptide binding]; other site
592021003558	substrate binding site [chemical binding]; other site
592021003559	active site
592021003560	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
592021003561	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
592021003562	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
592021003563	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
592021003564	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
592021003565	Part of AAA domain; Region: AAA_19; pfam13245
592021003566	Family description; Region: UvrD_C_2; pfam13538
592021003567	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
592021003568	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021003569	Coenzyme A binding pocket [chemical binding]; other site
592021003570	hypothetical protein; Provisional; Region: PRK13679
592021003571	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
592021003572	Putative esterase; Region: Esterase; pfam00756
592021003573	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
592021003574	EamA-like transporter family; Region: EamA; pfam00892
592021003575	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
592021003576	EamA-like transporter family; Region: EamA; pfam00892
592021003577	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
592021003578	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
592021003579	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
592021003580	Na binding site [ion binding]; other site
592021003581	anthranilate synthase component I; Provisional; Region: PRK13570
592021003582	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
592021003583	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
592021003584	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
592021003585	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
592021003586	glutamine binding [chemical binding]; other site
592021003587	catalytic triad [active]
592021003588	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
592021003589	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
592021003590	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
592021003591	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
592021003592	active site
592021003593	ribulose/triose binding site [chemical binding]; other site
592021003594	phosphate binding site [ion binding]; other site
592021003595	substrate (anthranilate) binding pocket [chemical binding]; other site
592021003596	product (indole) binding pocket [chemical binding]; other site
592021003597	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
592021003598	active site
592021003599	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
592021003600	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
592021003601	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021003602	catalytic residue [active]
592021003603	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
592021003604	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
592021003605	substrate binding site [chemical binding]; other site
592021003606	active site
592021003607	catalytic residues [active]
592021003608	heterodimer interface [polypeptide binding]; other site
592021003609	Protein of unknown function (DUF4029); Region: DUF4029; pfam13221
592021003610	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
592021003611	L-lactate permease; Region: Lactate_perm; cl00701
592021003612	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
592021003613	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
592021003614	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021003615	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
592021003616	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021003617	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
592021003618	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021003619	Coenzyme A binding pocket [chemical binding]; other site
592021003620	Protein of unknown function (DUF3908); Region: DUF3908; pfam13048
592021003621	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
592021003622	NADPH bind site [chemical binding]; other site
592021003623	putative FMN binding site [chemical binding]; other site
592021003624	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
592021003625	putative FMN binding site [chemical binding]; other site
592021003626	NADPH bind site [chemical binding]; other site
592021003627	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
592021003628	YcaO-like family; Region: YcaO; pfam02624
592021003629	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
592021003630	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
592021003631	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
592021003632	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
592021003633	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
592021003634	E3 interaction surface; other site
592021003635	lipoyl attachment site [posttranslational modification]; other site
592021003636	e3 binding domain; Region: E3_binding; pfam02817
592021003637	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
592021003638	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
592021003639	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
592021003640	TPP-binding site [chemical binding]; other site
592021003641	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
592021003642	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021003643	salt bridge; other site
592021003644	non-specific DNA binding site [nucleotide binding]; other site
592021003645	sequence-specific DNA binding site [nucleotide binding]; other site
592021003646	Domain of unknown function (DUF3976); Region: DUF3976; pfam13121
592021003647	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
592021003648	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
592021003649	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
592021003650	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
592021003651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021003652	S-adenosylmethionine binding site [chemical binding]; other site
592021003653	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021003654	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
592021003655	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
592021003656	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
592021003657	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
592021003658	Catalytic site [active]
592021003659	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
592021003660	Domain of unknown function (DUF4047); Region: DUF4047; pfam13256
592021003661	Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389
592021003662	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021003663	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021003664	non-specific DNA binding site [nucleotide binding]; other site
592021003665	salt bridge; other site
592021003666	sequence-specific DNA binding site [nucleotide binding]; other site
592021003667	Anti-repressor SinI; Region: SinI; pfam08671
592021003668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
592021003669	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
592021003670	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
592021003671	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
592021003672	NAD(P) binding site [chemical binding]; other site
592021003673	catalytic residues [active]
592021003674	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
592021003675	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
592021003676	Walker A/P-loop; other site
592021003677	ATP binding site [chemical binding]; other site
592021003678	Q-loop/lid; other site
592021003679	ABC transporter signature motif; other site
592021003680	Walker B; other site
592021003681	D-loop; other site
592021003682	H-loop/switch region; other site
592021003683	TOBE domain; Region: TOBE_2; pfam08402
592021003684	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
592021003685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021003686	dimer interface [polypeptide binding]; other site
592021003687	conserved gate region; other site
592021003688	putative PBP binding loops; other site
592021003689	ABC-ATPase subunit interface; other site
592021003690	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
592021003691	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
592021003692	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
592021003693	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
592021003694	active site
592021003695	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
592021003696	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
592021003697	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
592021003698	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
592021003699	active site
592021003700	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
592021003701	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
592021003702	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
592021003703	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
592021003704	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
592021003705	Cysteine-rich domain; Region: CCG; pfam02754
592021003706	Cysteine-rich domain; Region: CCG; pfam02754
592021003707	FAD binding domain; Region: FAD_binding_4; pfam01565
592021003708	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
592021003709	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
592021003710	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
592021003711	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
592021003712	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
592021003713	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
592021003714	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021003715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021003716	active site
592021003717	phosphorylation site [posttranslational modification]
592021003718	intermolecular recognition site; other site
592021003719	dimerization interface [polypeptide binding]; other site
592021003720	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021003721	DNA binding site [nucleotide binding]
592021003722	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
592021003723	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021003724	dimerization interface [polypeptide binding]; other site
592021003725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021003726	dimer interface [polypeptide binding]; other site
592021003727	phosphorylation site [posttranslational modification]
592021003728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021003729	ATP binding site [chemical binding]; other site
592021003730	Mg2+ binding site [ion binding]; other site
592021003731	G-X-G motif; other site
592021003732	Transcriptional regulators [Transcription]; Region: FadR; COG2186
592021003733	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021003734	DNA-binding site [nucleotide binding]; DNA binding site
592021003735	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
592021003736	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
592021003737	Cysteine-rich domain; Region: CCG; pfam02754
592021003738	Cysteine-rich domain; Region: CCG; pfam02754
592021003739	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
592021003740	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
592021003741	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
592021003742	Uncharacterized conserved protein [Function unknown]; Region: COG1556
592021003743	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
592021003744	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
592021003745	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
592021003746	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
592021003747	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
592021003748	yybP-ykoY leader
592021003749	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
592021003750	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
592021003751	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
592021003752	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
592021003753	dimer interaction site [polypeptide binding]; other site
592021003754	substrate-binding tunnel; other site
592021003755	active site
592021003756	catalytic site [active]
592021003757	substrate binding site [chemical binding]; other site
592021003758	Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820
592021003759	poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719
592021003760	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021003761	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
592021003762	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
592021003763	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
592021003764	NAD(P) binding site [chemical binding]; other site
592021003765	homotetramer interface [polypeptide binding]; other site
592021003766	homodimer interface [polypeptide binding]; other site
592021003767	active site
592021003768	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
592021003769	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
592021003770	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
592021003771	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
592021003772	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
592021003773	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
592021003774	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
592021003775	Protein of unknown function (DUF3905); Region: DUF3905; pfam13045
592021003776	putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261
592021003777	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
592021003778	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
592021003779	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021003780	motif II; other site
592021003781	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
592021003782	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021003783	catalytic residue [active]
592021003784	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
592021003785	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
592021003786	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
592021003787	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
592021003788	FOG: CBS domain [General function prediction only]; Region: COG0517
592021003789	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
592021003790	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
592021003791	NodB motif; other site
592021003792	putative active site [active]
592021003793	putative catalytic site [active]
592021003794	Zn binding site [ion binding]; other site
592021003795	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
592021003796	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
592021003797	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021003798	dimer interface [polypeptide binding]; other site
592021003799	phosphorylation site [posttranslational modification]
592021003800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021003801	ATP binding site [chemical binding]; other site
592021003802	Mg2+ binding site [ion binding]; other site
592021003803	G-X-G motif; other site
592021003804	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021003805	MarR family; Region: MarR; pfam01047
592021003806	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
592021003807	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
592021003808	active site
592021003809	Zn binding site [ion binding]; other site
592021003810	DinB superfamily; Region: DinB_2; pfam12867
592021003811	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
592021003812	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021003813	dimer interface [polypeptide binding]; other site
592021003814	phosphorylation site [posttranslational modification]
592021003815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021003816	ATP binding site [chemical binding]; other site
592021003817	Mg2+ binding site [ion binding]; other site
592021003818	G-X-G motif; other site
592021003819	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
592021003820	Ligand Binding Site [chemical binding]; other site
592021003821	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
592021003822	active site
592021003823	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
592021003824	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
592021003825	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
592021003826	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953
592021003827	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
592021003828	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021003829	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
592021003830	Coenzyme A binding pocket [chemical binding]; other site
592021003831	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
592021003832	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
592021003833	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
592021003834	N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437
592021003835	group I intron endonuclease; Region: grpIintron_endo; TIGR01453
592021003836	GIY-YIG motif/motif A; other site
592021003837	putative active site [active]
592021003838	catalytic site [active]
592021003839	putative metal binding site [ion binding]; other site
592021003840	GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508
592021003841	DNA binding site [nucleotide binding]
592021003842	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
592021003843	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
592021003844	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
592021003845	dimer interface [polypeptide binding]; other site
592021003846	putative radical transfer pathway; other site
592021003847	diiron center [ion binding]; other site
592021003848	tyrosyl radical; other site
592021003849	Predicted transcriptional regulators [Transcription]; Region: COG1725
592021003850	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021003851	DNA-binding site [nucleotide binding]; DNA binding site
592021003852	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
592021003853	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021003854	Walker A/P-loop; other site
592021003855	ATP binding site [chemical binding]; other site
592021003856	Q-loop/lid; other site
592021003857	ABC transporter signature motif; other site
592021003858	Walker B; other site
592021003859	D-loop; other site
592021003860	H-loop/switch region; other site
592021003861	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021003862	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021003863	Walker A/P-loop; other site
592021003864	ATP binding site [chemical binding]; other site
592021003865	Q-loop/lid; other site
592021003866	ABC transporter signature motif; other site
592021003867	Walker B; other site
592021003868	D-loop; other site
592021003869	H-loop/switch region; other site
592021003870	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
592021003871	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
592021003872	CAAX protease self-immunity; Region: Abi; pfam02517
592021003873	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
592021003874	Protein of unknown function (DUF3913); Region: DUF3913; pfam13052
592021003875	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
592021003876	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021003877	putative DNA binding site [nucleotide binding]; other site
592021003878	putative Zn2+ binding site [ion binding]; other site
592021003879	AsnC family; Region: AsnC_trans_reg; pfam01037
592021003880	Uncharacterized conserved protein [Function unknown]; Region: COG2128
592021003881	Isochorismatase family; Region: Isochorismatase; pfam00857
592021003882	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
592021003883	catalytic triad [active]
592021003884	conserved cis-peptide bond; other site
592021003885	SseB protein; Region: SseB; cl06279
592021003886	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
592021003887	dimer interface [polypeptide binding]; other site
592021003888	catalytic triad [active]
592021003889	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
592021003890	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
592021003891	FMN binding site [chemical binding]; other site
592021003892	substrate binding site [chemical binding]; other site
592021003893	putative catalytic residue [active]
592021003894	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
592021003895	DltD N-terminal region; Region: DltD_N; pfam04915
592021003896	DltD central region; Region: DltD_M; pfam04918
592021003897	DltD C-terminal region; Region: DltD_C; pfam04914
592021003898	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
592021003899	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
592021003900	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
592021003901	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
592021003902	acyl-activating enzyme (AAE) consensus motif; other site
592021003903	AMP binding site [chemical binding]; other site
592021003904	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
592021003905	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
592021003906	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
592021003907	metal binding site [ion binding]; metal-binding site
592021003908	dimer interface [polypeptide binding]; other site
592021003909	flavodoxin; Provisional; Region: PRK06756
592021003910	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
592021003911	Phosphotransferase enzyme family; Region: APH; pfam01636
592021003912	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
592021003913	active site
592021003914	substrate binding site [chemical binding]; other site
592021003915	ATP binding site [chemical binding]; other site
592021003916	Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908
592021003917	multidrug efflux protein; Reviewed; Region: PRK01766
592021003918	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
592021003919	cation binding site [ion binding]; other site
592021003920	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
592021003921	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
592021003922	catalytic residues [active]
592021003923	Regulatory protein YrvL; Region: YrvL; pfam14184
592021003924	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
592021003925	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
592021003926	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
592021003927	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
592021003928	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
592021003929	hypothetical protein; Provisional; Region: PRK03094
592021003930	Protein of unknown function (DUF3911); Region: DUF3911; pfam13050
592021003931	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
592021003932	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
592021003933	homodimer interface [polypeptide binding]; other site
592021003934	substrate-cofactor binding pocket; other site
592021003935	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021003936	catalytic residue [active]
592021003937	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
592021003938	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
592021003939	PYR/PP interface [polypeptide binding]; other site
592021003940	dimer interface [polypeptide binding]; other site
592021003941	TPP binding site [chemical binding]; other site
592021003942	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
592021003943	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
592021003944	TPP-binding site [chemical binding]; other site
592021003945	dimer interface [polypeptide binding]; other site
592021003946	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
592021003947	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
592021003948	putative valine binding site [chemical binding]; other site
592021003949	dimer interface [polypeptide binding]; other site
592021003950	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
592021003951	ketol-acid reductoisomerase; Provisional; Region: PRK05479
592021003952	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
592021003953	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
592021003954	2-isopropylmalate synthase; Validated; Region: PRK00915
592021003955	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
592021003956	active site
592021003957	catalytic residues [active]
592021003958	metal binding site [ion binding]; metal-binding site
592021003959	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
592021003960	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
592021003961	tartrate dehydrogenase; Region: TTC; TIGR02089
592021003962	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
592021003963	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
592021003964	substrate binding site [chemical binding]; other site
592021003965	ligand binding site [chemical binding]; other site
592021003966	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
592021003967	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
592021003968	substrate binding site [chemical binding]; other site
592021003969	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
592021003970	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
592021003971	dimer interface [polypeptide binding]; other site
592021003972	motif 1; other site
592021003973	active site
592021003974	motif 2; other site
592021003975	motif 3; other site
592021003976	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
592021003977	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
592021003978	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
592021003979	histidinol dehydrogenase; Region: hisD; TIGR00069
592021003980	NAD binding site [chemical binding]; other site
592021003981	dimerization interface [polypeptide binding]; other site
592021003982	product binding site; other site
592021003983	substrate binding site [chemical binding]; other site
592021003984	zinc binding site [ion binding]; other site
592021003985	catalytic residues [active]
592021003986	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
592021003987	putative active site pocket [active]
592021003988	4-fold oligomerization interface [polypeptide binding]; other site
592021003989	metal binding residues [ion binding]; metal-binding site
592021003990	3-fold/trimer interface [polypeptide binding]; other site
592021003991	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
592021003992	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
592021003993	putative active site [active]
592021003994	oxyanion strand; other site
592021003995	catalytic triad [active]
592021003996	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
592021003997	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
592021003998	catalytic residues [active]
592021003999	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
592021004000	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
592021004001	substrate binding site [chemical binding]; other site
592021004002	glutamase interaction surface [polypeptide binding]; other site
592021004003	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
592021004004	metal binding site [ion binding]; metal-binding site
592021004005	histidinol-phosphatase; Validated; Region: PRK06740
592021004006	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
592021004007	dimer interface [polypeptide binding]; other site
592021004008	active site
592021004009	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
592021004010	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
592021004011	putative ligand binding site [chemical binding]; other site
592021004012	putative NAD binding site [chemical binding]; other site
592021004013	catalytic site [active]
592021004014	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
592021004015	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
592021004016	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
592021004017	Sulfatase; Region: Sulfatase; pfam00884
592021004018	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
592021004019	diaminopimelate decarboxylase; Region: lysA; TIGR01048
592021004020	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
592021004021	active site
592021004022	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
592021004023	substrate binding site [chemical binding]; other site
592021004024	catalytic residues [active]
592021004025	dimer interface [polypeptide binding]; other site
592021004026	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
592021004027	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
592021004028	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
592021004029	Active Sites [active]
592021004030	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
592021004031	ATP-sulfurylase; Region: ATPS; cd00517
592021004032	active site
592021004033	HXXH motif; other site
592021004034	flexible loop; other site
592021004035	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
592021004036	ligand-binding site [chemical binding]; other site
592021004037	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
592021004038	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
592021004039	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
592021004040	Protein of unknown function (DUF3906); Region: DUF3906; pfam13046
592021004041	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
592021004042	diphthine synthase; Region: dph5; TIGR00522
592021004043	active site
592021004044	SAM binding site [chemical binding]; other site
592021004045	homodimer interface [polypeptide binding]; other site
592021004046	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
592021004047	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
592021004048	putative active site [active]
592021004049	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
592021004050	putative active site [active]
592021004051	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
592021004052	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
592021004053	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
592021004054	Na2 binding site [ion binding]; other site
592021004055	putative substrate binding site 1 [chemical binding]; other site
592021004056	Na binding site 1 [ion binding]; other site
592021004057	putative substrate binding site 2 [chemical binding]; other site
592021004058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
592021004059	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
592021004060	Peptidase family M23; Region: Peptidase_M23; pfam01551
592021004061	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
592021004062	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
592021004063	Protein of unknown function (DUF402); Region: DUF402; cl00979
592021004064	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
592021004065	Vpu protein; Region: Vpu; pfam00558
592021004066	PspA/IM30 family; Region: PspA_IM30; pfam04012
592021004067	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
592021004068	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
592021004069	Histidine kinase; Region: HisKA_3; pfam07730
592021004070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021004071	ATP binding site [chemical binding]; other site
592021004072	Mg2+ binding site [ion binding]; other site
592021004073	G-X-G motif; other site
592021004074	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
592021004075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021004076	active site
592021004077	phosphorylation site [posttranslational modification]
592021004078	intermolecular recognition site; other site
592021004079	dimerization interface [polypeptide binding]; other site
592021004080	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
592021004081	DNA binding residues [nucleotide binding]
592021004082	dimerization interface [polypeptide binding]; other site
592021004083	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
592021004084	E3 interaction surface; other site
592021004085	lipoyl attachment site [posttranslational modification]; other site
592021004086	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
592021004087	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021004088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021004089	S-adenosylmethionine binding site [chemical binding]; other site
592021004090	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
592021004091	Peptidase family M50; Region: Peptidase_M50; pfam02163
592021004092	active site
592021004093	putative substrate binding region [chemical binding]; other site
592021004094	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
592021004095	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
592021004096	heme-binding site [chemical binding]; other site
592021004097	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
592021004098	FAD binding pocket [chemical binding]; other site
592021004099	FAD binding motif [chemical binding]; other site
592021004100	phosphate binding motif [ion binding]; other site
592021004101	beta-alpha-beta structure motif; other site
592021004102	NAD binding pocket [chemical binding]; other site
592021004103	Heme binding  pocket [chemical binding]; other site
592021004104	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
592021004105	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
592021004106	ligand binding site [chemical binding]; other site
592021004107	flexible hinge region; other site
592021004108	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
592021004109	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
592021004110	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
592021004111	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
592021004112	Transglycosylase; Region: Transgly; pfam00912
592021004113	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
592021004114	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021004115	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
592021004116	Protein of unknown function DUF72; Region: DUF72; pfam01904
592021004117	Protein of unknown function (DUF3924); Region: DUF3924; pfam13062
592021004118	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
592021004119	active site
592021004120	DNA binding site [nucleotide binding]
592021004121	Int/Topo IB signature motif; other site
592021004122	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021004123	dimerization interface [polypeptide binding]; other site
592021004124	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021004125	dimer interface [polypeptide binding]; other site
592021004126	phosphorylation site [posttranslational modification]
592021004127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021004128	ATP binding site [chemical binding]; other site
592021004129	Mg2+ binding site [ion binding]; other site
592021004130	G-X-G motif; other site
592021004131	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
592021004132	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
592021004133	Probable transposase; Region: OrfB_IS605; pfam01385
592021004134	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
592021004135	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
592021004136	Predicted integral membrane protein [Function unknown]; Region: COG0392
592021004137	Uncharacterized conserved protein [Function unknown]; Region: COG2898
592021004138	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
592021004139	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
592021004140	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
592021004141	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
592021004142	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
592021004143	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021004144	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
592021004145	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
592021004146	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
592021004147	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
592021004148	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021004149	RNA binding surface [nucleotide binding]; other site
592021004150	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
592021004151	active site
592021004152	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
592021004153	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
592021004154	catalytic residues [active]
592021004155	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
592021004156	ResB-like family; Region: ResB; pfam05140
592021004157	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
592021004158	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
592021004159	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021004160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021004161	active site
592021004162	phosphorylation site [posttranslational modification]
592021004163	intermolecular recognition site; other site
592021004164	dimerization interface [polypeptide binding]; other site
592021004165	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021004166	DNA binding site [nucleotide binding]
592021004167	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
592021004168	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021004169	dimerization interface [polypeptide binding]; other site
592021004170	PAS domain; Region: PAS; smart00091
592021004171	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021004172	dimer interface [polypeptide binding]; other site
592021004173	phosphorylation site [posttranslational modification]
592021004174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021004175	ATP binding site [chemical binding]; other site
592021004176	Mg2+ binding site [ion binding]; other site
592021004177	G-X-G motif; other site
592021004178	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
592021004179	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
592021004180	Peptidase family M23; Region: Peptidase_M23; pfam01551
592021004181	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
592021004182	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
592021004183	Predicted membrane protein [Function unknown]; Region: COG3601
592021004184	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
592021004185	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
592021004186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
592021004187	DEAD-like helicases superfamily; Region: DEXDc; smart00487
592021004188	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021004189	ATP binding site [chemical binding]; other site
592021004190	putative Mg++ binding site [ion binding]; other site
592021004191	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021004192	nucleotide binding region [chemical binding]; other site
592021004193	ATP-binding site [chemical binding]; other site
592021004194	CAAX protease self-immunity; Region: Abi; pfam02517
592021004195	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
592021004196	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021004197	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
592021004198	DNA binding residues [nucleotide binding]
592021004199	B12 binding domain; Region: B12-binding_2; pfam02607
592021004200	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
592021004201	adaptor protein; Provisional; Region: PRK02899
592021004202	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
592021004203	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
592021004204	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
592021004205	NAD(P) binding site [chemical binding]; other site
592021004206	Domain of unknown function (DUF3961); Region: DUF3961; pfam13106
592021004207	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
592021004208	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
592021004209	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021004210	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
592021004211	active site
592021004212	homotetramer interface [polypeptide binding]; other site
592021004213	homodimer interface [polypeptide binding]; other site
592021004214	cytidylate kinase; Provisional; Region: cmk; PRK00023
592021004215	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
592021004216	CMP-binding site; other site
592021004217	The sites determining sugar specificity; other site
592021004218	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
592021004219	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
592021004220	RNA binding site [nucleotide binding]; other site
592021004221	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
592021004222	RNA binding site [nucleotide binding]; other site
592021004223	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
592021004224	RNA binding site [nucleotide binding]; other site
592021004225	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
592021004226	RNA binding site [nucleotide binding]; other site
592021004227	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
592021004228	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
592021004229	homotetramer interface [polypeptide binding]; other site
592021004230	FMN binding site [chemical binding]; other site
592021004231	homodimer contacts [polypeptide binding]; other site
592021004232	putative active site [active]
592021004233	putative substrate binding site [chemical binding]; other site
592021004234	YpzI-like protein; Region: YpzI; pfam14140
592021004235	YIEGIA protein; Region: YIEGIA; pfam14045
592021004236	GTP-binding protein Der; Reviewed; Region: PRK00093
592021004237	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
592021004238	G1 box; other site
592021004239	GTP/Mg2+ binding site [chemical binding]; other site
592021004240	Switch I region; other site
592021004241	G2 box; other site
592021004242	Switch II region; other site
592021004243	G3 box; other site
592021004244	G4 box; other site
592021004245	G5 box; other site
592021004246	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
592021004247	G1 box; other site
592021004248	GTP/Mg2+ binding site [chemical binding]; other site
592021004249	Switch I region; other site
592021004250	G2 box; other site
592021004251	G3 box; other site
592021004252	Switch II region; other site
592021004253	G4 box; other site
592021004254	G5 box; other site
592021004255	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
592021004256	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
592021004257	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
592021004258	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
592021004259	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
592021004260	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
592021004261	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
592021004262	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
592021004263	IHF dimer interface [polypeptide binding]; other site
592021004264	IHF - DNA interface [nucleotide binding]; other site
592021004265	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
592021004266	homodecamer interface [polypeptide binding]; other site
592021004267	GTP cyclohydrolase I; Provisional; Region: PLN03044
592021004268	active site
592021004269	putative catalytic site residues [active]
592021004270	zinc binding site [ion binding]; other site
592021004271	GTP-CH-I/GFRP interaction surface; other site
592021004272	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
592021004273	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
592021004274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021004275	S-adenosylmethionine binding site [chemical binding]; other site
592021004276	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
592021004277	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
592021004278	substrate binding pocket [chemical binding]; other site
592021004279	chain length determination region; other site
592021004280	substrate-Mg2+ binding site; other site
592021004281	catalytic residues [active]
592021004282	aspartate-rich region 1; other site
592021004283	active site lid residues [active]
592021004284	aspartate-rich region 2; other site
592021004285	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
592021004286	active site
592021004287	multimer interface [polypeptide binding]; other site
592021004288	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
592021004289	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
592021004290	Tetramer interface [polypeptide binding]; other site
592021004291	active site
592021004292	FMN-binding site [chemical binding]; other site
592021004293	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
592021004294	active site
592021004295	dimer interface [polypeptide binding]; other site
592021004296	metal binding site [ion binding]; metal-binding site
592021004297	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
592021004298	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021004299	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021004300	homodimer interface [polypeptide binding]; other site
592021004301	catalytic residue [active]
592021004302	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021004303	binding surface
592021004304	TPR motif; other site
592021004305	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
592021004306	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021004307	binding surface
592021004308	TPR motif; other site
592021004309	Tetratricopeptide repeat; Region: TPR_12; pfam13424
592021004310	TPR repeat; Region: TPR_11; pfam13414
592021004311	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021004312	binding surface
592021004313	TPR motif; other site
592021004314	hypothetical protein; Provisional; Region: PRK03636
592021004315	UPF0302 domain; Region: UPF0302; pfam08864
592021004316	IDEAL domain; Region: IDEAL; pfam08858
592021004317	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
592021004318	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
592021004319	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
592021004320	iron-sulfur cluster [ion binding]; other site
592021004321	[2Fe-2S] cluster binding site [ion binding]; other site
592021004322	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
592021004323	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
592021004324	interchain domain interface [polypeptide binding]; other site
592021004325	intrachain domain interface; other site
592021004326	heme bH binding site [chemical binding]; other site
592021004327	Qi binding site; other site
592021004328	heme bL binding site [chemical binding]; other site
592021004329	Qo binding site; other site
592021004330	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
592021004331	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
592021004332	interchain domain interface [polypeptide binding]; other site
592021004333	intrachain domain interface; other site
592021004334	Qi binding site; other site
592021004335	Qo binding site; other site
592021004336	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
592021004337	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
592021004338	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
592021004339	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
592021004340	sporulation protein YpjB; Region: spore_ypjB; TIGR02878
592021004341	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
592021004342	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
592021004343	active site
592021004344	Fe-S cluster binding site [ion binding]; other site
592021004345	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021004346	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021004347	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021004348	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021004349	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
592021004350	homodimer interface [polypeptide binding]; other site
592021004351	metal binding site [ion binding]; metal-binding site
592021004352	dihydrodipicolinate reductase; Provisional; Region: PRK00048
592021004353	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
592021004354	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
592021004355	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
592021004356	active site
592021004357	dimer interfaces [polypeptide binding]; other site
592021004358	catalytic residues [active]
592021004359	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
592021004360	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
592021004361	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
592021004362	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
592021004363	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
592021004364	active site
592021004365	NTP binding site [chemical binding]; other site
592021004366	metal binding triad [ion binding]; metal-binding site
592021004367	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
592021004368	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
592021004369	Biotin operon repressor [Transcription]; Region: BirA; COG1654
592021004370	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
592021004371	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
592021004372	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
592021004373	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
592021004374	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
592021004375	oligomerization interface [polypeptide binding]; other site
592021004376	active site
592021004377	metal binding site [ion binding]; metal-binding site
592021004378	pantoate--beta-alanine ligase; Region: panC; TIGR00018
592021004379	Pantoate-beta-alanine ligase; Region: PanC; cd00560
592021004380	active site
592021004381	ATP-binding site [chemical binding]; other site
592021004382	pantoate-binding site; other site
592021004383	HXXH motif; other site
592021004384	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
592021004385	tetramerization interface [polypeptide binding]; other site
592021004386	active site
592021004387	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
592021004388	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
592021004389	active site
592021004390	catalytic site [active]
592021004391	substrate binding site [chemical binding]; other site
592021004392	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
592021004393	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021004394	nucleotide binding region [chemical binding]; other site
592021004395	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
592021004396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
592021004397	aspartate aminotransferase; Provisional; Region: PRK05764
592021004398	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021004399	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021004400	homodimer interface [polypeptide binding]; other site
592021004401	catalytic residue [active]
592021004402	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
592021004403	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
592021004404	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
592021004405	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
592021004406	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
592021004407	minor groove reading motif; other site
592021004408	helix-hairpin-helix signature motif; other site
592021004409	substrate binding pocket [chemical binding]; other site
592021004410	active site
592021004411	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
592021004412	Transglycosylase; Region: Transgly; pfam00912
592021004413	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
592021004414	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
592021004415	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
592021004416	Interdomain contacts; other site
592021004417	Cytokine receptor motif; other site
592021004418	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
592021004419	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
592021004420	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
592021004421	YppF-like protein; Region: YppF; pfam14178
592021004422	YppG-like protein; Region: YppG; pfam14179
592021004423	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
592021004424	hypothetical protein; Provisional; Region: PRK13660
592021004425	cell division protein GpsB; Provisional; Region: PRK14127
592021004426	DivIVA domain; Region: DivI1A_domain; TIGR03544
592021004427	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
592021004428	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
592021004429	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
592021004430	Protein of unknown function (DUF3921); Region: DUF3921; pfam13060
592021004431	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
592021004432	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
592021004433	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
592021004434	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
592021004435	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
592021004436	active site
592021004437	Zn binding site [ion binding]; other site
592021004438	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021004439	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021004440	Coenzyme A binding pocket [chemical binding]; other site
592021004441	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
592021004442	Phosphotransferase enzyme family; Region: APH; pfam01636
592021004443	putative active site [active]
592021004444	putative substrate binding site [chemical binding]; other site
592021004445	ATP binding site [chemical binding]; other site
592021004446	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
592021004447	active site
592021004448	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021004449	active site
592021004450	xanthine permease; Region: pbuX; TIGR03173
592021004451	Predicted membrane protein [Function unknown]; Region: COG2311
592021004452	Protein of unknown function (DUF418); Region: DUF418; cl12135
592021004453	Protein of unknown function (DUF418); Region: DUF418; pfam04235
592021004454	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
592021004455	Dynamin family; Region: Dynamin_N; pfam00350
592021004456	G1 box; other site
592021004457	GTP/Mg2+ binding site [chemical binding]; other site
592021004458	G2 box; other site
592021004459	Switch I region; other site
592021004460	G3 box; other site
592021004461	Switch II region; other site
592021004462	G4 box; other site
592021004463	G5 box; other site
592021004464	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
592021004465	Dynamin family; Region: Dynamin_N; pfam00350
592021004466	G1 box; other site
592021004467	GTP/Mg2+ binding site [chemical binding]; other site
592021004468	G2 box; other site
592021004469	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
592021004470	G3 box; other site
592021004471	Switch II region; other site
592021004472	GTP/Mg2+ binding site [chemical binding]; other site
592021004473	G4 box; other site
592021004474	G5 box; other site
592021004475	Protein of unknown function (DUF3931); Region: DUF3931; pfam13082
592021004476	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021004477	Coenzyme A binding pocket [chemical binding]; other site
592021004478	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
592021004479	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
592021004480	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
592021004481	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
592021004482	active site residue [active]
592021004483	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
592021004484	active site residue [active]
592021004485	Predicted membrane protein [Function unknown]; Region: COG3766
592021004486	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
592021004487	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
592021004488	ykoK leader
592021004489	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
592021004490	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
592021004491	5'-3' exonuclease; Region: 53EXOc; smart00475
592021004492	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
592021004493	active site
592021004494	metal binding site 1 [ion binding]; metal-binding site
592021004495	putative 5' ssDNA interaction site; other site
592021004496	metal binding site 3; metal-binding site
592021004497	metal binding site 2 [ion binding]; metal-binding site
592021004498	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
592021004499	putative DNA binding site [nucleotide binding]; other site
592021004500	putative metal binding site [ion binding]; other site
592021004501	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
592021004502	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
592021004503	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
592021004504	Chain length determinant protein; Region: Wzz; cl15801
592021004505	Bacterial sugar transferase; Region: Bac_transf; pfam02397
592021004506	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
592021004507	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
592021004508	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
592021004509	O-Antigen ligase; Region: Wzy_C; pfam04932
592021004510	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
592021004511	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
592021004512	active site
592021004513	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
592021004514	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004515	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004516	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004517	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004518	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004519	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004520	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004521	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004522	Domain of unknown function DUF11; Region: DUF11; cl17728
592021004523	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004524	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004525	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004526	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004527	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004528	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004529	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004530	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004531	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004532	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004533	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004534	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004535	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004536	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004537	Domain of unknown function DUF11; Region: DUF11; cl17728
592021004538	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004539	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004540	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021004541	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021004542	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021004543	Coenzyme A binding pocket [chemical binding]; other site
592021004544	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
592021004545	Isochorismatase family; Region: Isochorismatase; pfam00857
592021004546	catalytic triad [active]
592021004547	conserved cis-peptide bond; other site
592021004548	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021004549	EamA-like transporter family; Region: EamA; pfam00892
592021004550	EamA-like transporter family; Region: EamA; cl17759
592021004551	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
592021004552	RNA/DNA hybrid binding site [nucleotide binding]; other site
592021004553	active site
592021004554	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
592021004555	active site
592021004556	catalytic residues [active]
592021004557	QueT transporter; Region: QueT; pfam06177
592021004558	hypothetical protein; Validated; Region: PRK07708
592021004559	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
592021004560	RNA/DNA hybrid binding site [nucleotide binding]; other site
592021004561	active site
592021004562	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
592021004563	Protein of unknown function (DUF2564); Region: DUF2564; pfam10819
592021004564	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
592021004565	DNA-binding site [nucleotide binding]; DNA binding site
592021004566	RNA-binding motif; other site
592021004567	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
592021004568	LysE type translocator; Region: LysE; pfam01810
592021004569	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
592021004570	Protein of unknown function, DUF485; Region: DUF485; pfam04341
592021004571	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
592021004572	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
592021004573	Na binding site [ion binding]; other site
592021004574	aminotransferase; Validated; Region: PRK07678
592021004575	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021004576	inhibitor-cofactor binding pocket; inhibition site
592021004577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021004578	catalytic residue [active]
592021004579	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
592021004580	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
592021004581	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
592021004582	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
592021004583	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
592021004584	DNA binding residues [nucleotide binding]
592021004585	drug binding residues [chemical binding]; other site
592021004586	dimer interface [polypeptide binding]; other site
592021004587	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
592021004588	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
592021004589	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
592021004590	Predicted membrane protein [Function unknown]; Region: COG2323
592021004591	Uncharacterized conserved protein [Function unknown]; Region: COG1434
592021004592	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
592021004593	putative active site [active]
592021004594	Tic20-like protein; Region: Tic20; pfam09685
592021004595	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
592021004596	dimer interface [polypeptide binding]; other site
592021004597	FMN binding site [chemical binding]; other site
592021004598	NADPH bind site [chemical binding]; other site
592021004599	DJ-1 family protein; Region: not_thiJ; TIGR01383
592021004600	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
592021004601	conserved cys residue [active]
592021004602	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
592021004603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021004604	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021004605	putative substrate translocation pore; other site
592021004606	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021004607	dimerization interface [polypeptide binding]; other site
592021004608	putative DNA binding site [nucleotide binding]; other site
592021004609	putative Zn2+ binding site [ion binding]; other site
592021004610	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021004611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021004612	putative substrate translocation pore; other site
592021004613	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
592021004614	active site
592021004615	metal binding site [ion binding]; metal-binding site
592021004616	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021004617	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
592021004618	bacterial Hfq-like; Region: Hfq; cd01716
592021004619	hexamer interface [polypeptide binding]; other site
592021004620	Sm1 motif; other site
592021004621	RNA binding site [nucleotide binding]; other site
592021004622	Sm2 motif; other site
592021004623	HD domain; Region: HD_3; pfam13023
592021004624	flagellar motor protein MotS; Reviewed; Region: PRK06742
592021004625	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
592021004626	ligand binding site [chemical binding]; other site
592021004627	Response regulator receiver domain; Region: Response_reg; pfam00072
592021004628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021004629	active site
592021004630	phosphorylation site [posttranslational modification]
592021004631	intermolecular recognition site; other site
592021004632	dimerization interface [polypeptide binding]; other site
592021004633	flagellar motor switch protein; Reviewed; Region: PRK06782
592021004634	CheC-like family; Region: CheC; pfam04509
592021004635	CheC-like family; Region: CheC; pfam04509
592021004636	CheC-like family; Region: CheC; pfam04509
592021004637	CheC-like family; Region: CheC; pfam04509
592021004638	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
592021004639	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
592021004640	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
592021004641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021004642	Protein of unknown function (DUF327); Region: DUF327; pfam03885
592021004643	Glutamate-cysteine ligase; Region: GshA; pfam08886
592021004644	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
592021004645	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
592021004646	flagellar capping protein; Validated; Region: fliD; PRK06798
592021004647	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
592021004648	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
592021004649	Flagellar protein FliS; Region: FliS; cl00654
592021004650	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
592021004651	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
592021004652	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
592021004653	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
592021004654	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
592021004655	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
592021004656	FliG C-terminal domain; Region: FliG_C; pfam01706
592021004657	flagellar assembly protein H; Validated; Region: fliH; PRK06800
592021004658	Flagellar assembly protein FliH; Region: FliH; pfam02108
592021004659	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
592021004660	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
592021004661	Walker A motif; other site
592021004662	ATP binding site [chemical binding]; other site
592021004663	Walker B motif; other site
592021004664	flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792
592021004665	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
592021004666	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
592021004667	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
592021004668	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
592021004669	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
592021004670	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
592021004671	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
592021004672	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
592021004673	TPR repeat; Region: TPR_11; pfam13414
592021004674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021004675	binding surface
592021004676	TPR motif; other site
592021004677	flagellin; Provisional; Region: PRK12807
592021004678	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
592021004679	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
592021004680	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
592021004681	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
592021004682	N-acetyl-D-glucosamine binding site [chemical binding]; other site
592021004683	catalytic residue [active]
592021004684	flagellar motor switch protein; Validated; Region: PRK06788
592021004685	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
592021004686	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
592021004687	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
592021004688	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
592021004689	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
592021004690	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
592021004691	FHIPEP family; Region: FHIPEP; pfam00771
592021004692	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
592021004693	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
592021004694	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
592021004695	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
592021004696	Predicted transcriptional regulators [Transcription]; Region: COG1378
592021004697	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
592021004698	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
592021004699	C-terminal domain interface [polypeptide binding]; other site
592021004700	sugar binding site [chemical binding]; other site
592021004701	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
592021004702	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
592021004703	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
592021004704	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021004705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021004706	Dienelactone hydrolase family; Region: DLH; pfam01738
592021004707	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
592021004708	small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861
592021004709	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021004710	non-specific DNA binding site [nucleotide binding]; other site
592021004711	salt bridge; other site
592021004712	sequence-specific DNA binding site [nucleotide binding]; other site
592021004713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021004714	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021004715	putative substrate translocation pore; other site
592021004716	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
592021004717	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021004718	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021004719	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021004720	dimerization interface [polypeptide binding]; other site
592021004721	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
592021004722	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
592021004723	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
592021004724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021004725	dimer interface [polypeptide binding]; other site
592021004726	conserved gate region; other site
592021004727	putative PBP binding loops; other site
592021004728	ABC-ATPase subunit interface; other site
592021004729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021004730	dimer interface [polypeptide binding]; other site
592021004731	conserved gate region; other site
592021004732	putative PBP binding loops; other site
592021004733	ABC-ATPase subunit interface; other site
592021004734	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
592021004735	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
592021004736	Beta-Casp domain; Region: Beta-Casp; pfam10996
592021004737	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
592021004738	Cupin; Region: Cupin_1; smart00835
592021004739	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
592021004740	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
592021004741	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
592021004742	catalytic core [active]
592021004743	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021004744	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
592021004745	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
592021004746	active site
592021004747	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
592021004748	dimer interface [polypeptide binding]; other site
592021004749	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
592021004750	Ligand Binding Site [chemical binding]; other site
592021004751	Molecular Tunnel; other site
592021004752	RNA polymerase factor sigma-70; Validated; Region: PRK06811
592021004753	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021004754	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021004755	DNA binding residues [nucleotide binding]
592021004756	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
592021004757	VPS10 domain; Region: VPS10; smart00602
592021004758	VPS10 domain; Region: VPS10; smart00602
592021004759	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
592021004760	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
592021004761	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021004762	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
592021004763	DNA-binding site [nucleotide binding]; DNA binding site
592021004764	FCD domain; Region: FCD; pfam07729
592021004765	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021004766	EamA-like transporter family; Region: EamA; pfam00892
592021004767	EamA-like transporter family; Region: EamA; pfam00892
592021004768	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
592021004769	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
592021004770	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
592021004771	Predicted permeases [General function prediction only]; Region: COG0701
592021004772	TIGR03943 family protein; Region: TIGR03943
592021004773	Methyltransferase domain; Region: Methyltransf_24; pfam13578
592021004774	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
592021004775	fumarate hydratase; Reviewed; Region: fumC; PRK00485
592021004776	Class II fumarases; Region: Fumarase_classII; cd01362
592021004777	active site
592021004778	tetramer interface [polypeptide binding]; other site
592021004779	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
592021004780	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
592021004781	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
592021004782	active site pocket [active]
592021004783	oxyanion hole [active]
592021004784	catalytic triad [active]
592021004785	active site nucleophile [active]
592021004786	Protein of unknown function (DUF3942); Region: DUF3942; pfam13078
592021004787	Penicillinase repressor; Region: Pencillinase_R; pfam03965
592021004788	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
592021004789	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
592021004790	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
592021004791	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
592021004792	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
592021004793	catalytic residues [active]
592021004794	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
592021004795	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
592021004796	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021004797	non-specific DNA binding site [nucleotide binding]; other site
592021004798	salt bridge; other site
592021004799	sequence-specific DNA binding site [nucleotide binding]; other site
592021004800	Cupin domain; Region: Cupin_2; pfam07883
592021004801	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
592021004802	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
592021004803	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021004804	catalytic residue [active]
592021004805	Protein of unknown function (DUF445); Region: DUF445; pfam04286
592021004806	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
592021004807	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021004808	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021004809	DNA binding residues [nucleotide binding]
592021004810	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
592021004811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021004812	active site
592021004813	phosphorylation site [posttranslational modification]
592021004814	intermolecular recognition site; other site
592021004815	dimerization interface [polypeptide binding]; other site
592021004816	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
592021004817	DNA binding residues [nucleotide binding]
592021004818	dimerization interface [polypeptide binding]; other site
592021004819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
592021004820	Histidine kinase; Region: HisKA_3; pfam07730
592021004821	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021004822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021004823	Walker A/P-loop; other site
592021004824	ATP binding site [chemical binding]; other site
592021004825	Q-loop/lid; other site
592021004826	ABC transporter signature motif; other site
592021004827	Walker B; other site
592021004828	D-loop; other site
592021004829	H-loop/switch region; other site
592021004830	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
592021004831	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
592021004832	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
592021004833	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
592021004834	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
592021004835	PLD-like domain; Region: PLDc_2; pfam13091
592021004836	putative active site [active]
592021004837	catalytic site [active]
592021004838	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
592021004839	PLD-like domain; Region: PLDc_2; pfam13091
592021004840	putative active site [active]
592021004841	catalytic site [active]
592021004842	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
592021004843	putative nucleotide binding site [chemical binding]; other site
592021004844	uridine monophosphate binding site [chemical binding]; other site
592021004845	homohexameric interface [polypeptide binding]; other site
592021004846	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
592021004847	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
592021004848	aspartate ammonia-lyase; Provisional; Region: PRK14515
592021004849	Aspartase; Region: Aspartase; cd01357
592021004850	active sites [active]
592021004851	tetramer interface [polypeptide binding]; other site
592021004852	malate dehydrogenase; Provisional; Region: PRK13529
592021004853	Malic enzyme, N-terminal domain; Region: malic; pfam00390
592021004854	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
592021004855	NAD(P) binding site [chemical binding]; other site
592021004856	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021004857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021004858	ATP binding site [chemical binding]; other site
592021004859	Mg2+ binding site [ion binding]; other site
592021004860	G-X-G motif; other site
592021004861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021004862	Response regulator receiver domain; Region: Response_reg; pfam00072
592021004863	active site
592021004864	phosphorylation site [posttranslational modification]
592021004865	intermolecular recognition site; other site
592021004866	dimerization interface [polypeptide binding]; other site
592021004867	YcbB domain; Region: YcbB; pfam08664
592021004868	SWIM zinc finger; Region: SWIM; pfam04434
592021004869	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
592021004870	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
592021004871	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021004872	ATP binding site [chemical binding]; other site
592021004873	putative Mg++ binding site [ion binding]; other site
592021004874	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021004875	nucleotide binding region [chemical binding]; other site
592021004876	ATP-binding site [chemical binding]; other site
592021004877	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
592021004878	dimer interface [polypeptide binding]; other site
592021004879	active site
592021004880	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
592021004881	putative dimer interface [polypeptide binding]; other site
592021004882	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021004883	aspartate kinase; Reviewed; Region: PRK06635
592021004884	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
592021004885	putative nucleotide binding site [chemical binding]; other site
592021004886	putative catalytic residues [active]
592021004887	putative Mg ion binding site [ion binding]; other site
592021004888	putative aspartate binding site [chemical binding]; other site
592021004889	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
592021004890	putative allosteric regulatory site; other site
592021004891	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
592021004892	putative allosteric regulatory residue; other site
592021004893	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
592021004894	YndJ-like protein; Region: YndJ; pfam14158
592021004895	S-layer homology domain; Region: SLH; pfam00395
592021004896	S-layer homology domain; Region: SLH; pfam00395
592021004897	S-layer homology domain; Region: SLH; pfam00395
592021004898	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
592021004899	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
592021004900	active site
592021004901	metal binding site [ion binding]; metal-binding site
592021004902	S-layer homology domain; Region: SLH; pfam00395
592021004903	S-layer homology domain; Region: SLH; pfam00395
592021004904	S-layer homology domain; Region: SLH; pfam00395
592021004905	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
592021004906	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021004907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021004908	putative substrate translocation pore; other site
592021004909	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
592021004910	Carbon starvation protein CstA; Region: CstA; pfam02554
592021004911	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
592021004912	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
592021004913	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
592021004914	dimer interface [polypeptide binding]; other site
592021004915	active site
592021004916	CoA binding pocket [chemical binding]; other site
592021004917	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
592021004918	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
592021004919	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
592021004920	HflX GTPase family; Region: HflX; cd01878
592021004921	G1 box; other site
592021004922	GTP/Mg2+ binding site [chemical binding]; other site
592021004923	Switch I region; other site
592021004924	G2 box; other site
592021004925	G3 box; other site
592021004926	Switch II region; other site
592021004927	G4 box; other site
592021004928	G5 box; other site
592021004929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021004930	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021004931	putative substrate translocation pore; other site
592021004932	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
592021004933	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
592021004934	dimer interface [polypeptide binding]; other site
592021004935	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021004936	catalytic residue [active]
592021004937	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021004938	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021004939	Coenzyme A binding pocket [chemical binding]; other site
592021004940	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
592021004941	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
592021004942	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
592021004943	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
592021004944	Na2 binding site [ion binding]; other site
592021004945	putative substrate binding site 1 [chemical binding]; other site
592021004946	Na binding site 1 [ion binding]; other site
592021004947	putative substrate binding site 2 [chemical binding]; other site
592021004948	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
592021004949	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
592021004950	NodB motif; other site
592021004951	putative active site [active]
592021004952	putative catalytic site [active]
592021004953	putative Zn binding site [ion binding]; other site
592021004954	Mor transcription activator family; Region: Mor; cl02360
592021004955	Predicted membrane protein [Function unknown]; Region: COG2323
592021004956	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
592021004957	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
592021004958	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
592021004959	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
592021004960	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
592021004961	methionine sulfoxide reductase A; Provisional; Region: PRK14054
592021004962	short chain dehydrogenase; Provisional; Region: PRK12747
592021004963	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
592021004964	NADP binding site [chemical binding]; other site
592021004965	homodimer interface [polypeptide binding]; other site
592021004966	active site
592021004967	substrate binding site [chemical binding]; other site
592021004968	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
592021004969	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
592021004970	homodimer interface [polypeptide binding]; other site
592021004971	substrate-cofactor binding pocket; other site
592021004972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021004973	catalytic residue [active]
592021004974	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725
592021004975	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
592021004976	PYR/PP interface [polypeptide binding]; other site
592021004977	dimer interface [polypeptide binding]; other site
592021004978	TPP binding site [chemical binding]; other site
592021004979	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
592021004980	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
592021004981	TPP-binding site [chemical binding]; other site
592021004982	dimer interface [polypeptide binding]; other site
592021004983	acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737
592021004984	ketol-acid reductoisomerase; Provisional; Region: PRK05479
592021004985	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
592021004986	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
592021004987	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
592021004988	threonine dehydratase; Validated; Region: PRK08639
592021004989	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
592021004990	tetramer interface [polypeptide binding]; other site
592021004991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021004992	catalytic residue [active]
592021004993	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
592021004994	putative Ile/Val binding site [chemical binding]; other site
592021004995	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
592021004996	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
592021004997	putative active site [active]
592021004998	putative metal binding site [ion binding]; other site
592021004999	Protein of unknown function (DUF554); Region: DUF554; pfam04474
592021005000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021005001	Coenzyme A binding pocket [chemical binding]; other site
592021005002	drug efflux system protein MdtG; Provisional; Region: PRK09874
592021005003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021005004	putative substrate translocation pore; other site
592021005005	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
592021005006	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
592021005007	putative active site [active]
592021005008	metal binding site [ion binding]; metal-binding site
592021005009	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
592021005010	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
592021005011	LytTr DNA-binding domain; Region: LytTR; pfam04397
592021005012	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
592021005013	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
592021005014	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
592021005015	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
592021005016	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021005017	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005018	Coenzyme A binding pocket [chemical binding]; other site
592021005019	5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493
592021005020	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
592021005021	active site
592021005022	putative substrate binding pocket [chemical binding]; other site
592021005023	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021005024	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
592021005025	hypothetical protein; Provisional; Region: PRK06922
592021005026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021005027	S-adenosylmethionine binding site [chemical binding]; other site
592021005028	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
592021005029	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021005030	FeS/SAM binding site; other site
592021005031	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
592021005032	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021005033	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005034	Coenzyme A binding pocket [chemical binding]; other site
592021005035	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021005036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021005037	active site
592021005038	phosphorylation site [posttranslational modification]
592021005039	intermolecular recognition site; other site
592021005040	dimerization interface [polypeptide binding]; other site
592021005041	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021005042	DNA binding site [nucleotide binding]
592021005043	manganese transport protein MntH; Reviewed; Region: PRK00701
592021005044	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
592021005045	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
592021005046	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
592021005047	active site residue [active]
592021005048	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
592021005049	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
592021005050	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
592021005051	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
592021005052	ydaO/yuaA leader
592021005053	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
592021005054	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
592021005055	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
592021005056	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
592021005057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021005058	DNA binding residues [nucleotide binding]
592021005059	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
592021005060	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
592021005061	intersubunit interface [polypeptide binding]; other site
592021005062	active site
592021005063	catalytic residue [active]
592021005064	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
592021005065	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
592021005066	Nucleoside recognition; Region: Gate; pfam07670
592021005067	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
592021005068	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
592021005069	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
592021005070	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
592021005071	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
592021005072	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
592021005073	active site
592021005074	catalytic motif [active]
592021005075	Zn binding site [ion binding]; other site
592021005076	hypothetical protein; Provisional; Region: PRK01631
592021005077	Family description; Region: DsbD_2; pfam13386
592021005078	VPS10 domain; Region: VPS10; smart00602
592021005079	proline aminopeptidase P II; Provisional; Region: PRK10879
592021005080	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
592021005081	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
592021005082	active site
592021005083	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
592021005084	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
592021005085	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
592021005086	Multicopper oxidase; Region: Cu-oxidase; pfam00394
592021005087	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
592021005088	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021005089	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021005090	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021005091	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021005092	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
592021005093	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021005094	Peptidase family M23; Region: Peptidase_M23; pfam01551
592021005095	DNA topoisomerase III; Provisional; Region: PRK07726
592021005096	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
592021005097	active site
592021005098	putative interdomain interaction site [polypeptide binding]; other site
592021005099	putative metal-binding site [ion binding]; other site
592021005100	putative nucleotide binding site [chemical binding]; other site
592021005101	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
592021005102	domain I; other site
592021005103	DNA binding groove [nucleotide binding]
592021005104	phosphate binding site [ion binding]; other site
592021005105	domain II; other site
592021005106	domain III; other site
592021005107	nucleotide binding site [chemical binding]; other site
592021005108	catalytic site [active]
592021005109	domain IV; other site
592021005110	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
592021005111	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
592021005112	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
592021005113	Sodium Bile acid symporter family; Region: SBF; cl17470
592021005114	azoreductase; Provisional; Region: PRK13555
592021005115	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021005116	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
592021005117	dimer interface [polypeptide binding]; other site
592021005118	substrate binding site [chemical binding]; other site
592021005119	metal binding site [ion binding]; metal-binding site
592021005120	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
592021005121	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
592021005122	YtkA-like; Region: YtkA; pfam13115
592021005123	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
592021005124	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021005125	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
592021005126	EamA-like transporter family; Region: EamA; pfam00892
592021005127	EamA-like transporter family; Region: EamA; pfam00892
592021005128	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021005129	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021005130	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021005131	dimerization interface [polypeptide binding]; other site
592021005132	Predicted transcriptional regulator [Transcription]; Region: COG1959
592021005133	Transcriptional regulator; Region: Rrf2; pfam02082
592021005134	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
592021005135	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
592021005136	catalytic residues [active]
592021005137	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
592021005138	dimer interface [polypeptide binding]; other site
592021005139	FMN binding site [chemical binding]; other site
592021005140	amidase; Provisional; Region: PRK06707
592021005141	Amidase; Region: Amidase; cl11426
592021005142	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
592021005143	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
592021005144	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
592021005145	tetramer (dimer of dimers) interface [polypeptide binding]; other site
592021005146	NAD binding site [chemical binding]; other site
592021005147	dimer interface [polypeptide binding]; other site
592021005148	substrate binding site [chemical binding]; other site
592021005149	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
592021005150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
592021005151	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
592021005152	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
592021005153	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
592021005154	S-layer homology domain; Region: SLH; pfam00395
592021005155	S-layer homology domain; Region: SLH; pfam00395
592021005156	S-layer homology domain; Region: SLH; pfam00395
592021005157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021005158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021005159	acyl-CoA synthetase; Validated; Region: PRK06839
592021005160	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
592021005161	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
592021005162	acyl-activating enzyme (AAE) consensus motif; other site
592021005163	putative AMP binding site [chemical binding]; other site
592021005164	putative active site [active]
592021005165	putative CoA binding site [chemical binding]; other site
592021005166	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
592021005167	dimer interaction site [polypeptide binding]; other site
592021005168	substrate-binding tunnel; other site
592021005169	active site
592021005170	catalytic site [active]
592021005171	substrate binding site [chemical binding]; other site
592021005172	hypothetical protein; Validated; Region: PRK06840
592021005173	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
592021005174	active site
592021005175	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
592021005176	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
592021005177	putative ligand binding site [chemical binding]; other site
592021005178	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
592021005179	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
592021005180	Walker A/P-loop; other site
592021005181	ATP binding site [chemical binding]; other site
592021005182	Q-loop/lid; other site
592021005183	ABC transporter signature motif; other site
592021005184	Walker B; other site
592021005185	D-loop; other site
592021005186	H-loop/switch region; other site
592021005187	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
592021005188	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
592021005189	Walker A/P-loop; other site
592021005190	ATP binding site [chemical binding]; other site
592021005191	Q-loop/lid; other site
592021005192	ABC transporter signature motif; other site
592021005193	Walker B; other site
592021005194	D-loop; other site
592021005195	H-loop/switch region; other site
592021005196	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
592021005197	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
592021005198	TM-ABC transporter signature motif; other site
592021005199	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
592021005200	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
592021005201	TM-ABC transporter signature motif; other site
592021005202	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021005203	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
592021005204	LysR substrate binding domain; Region: LysR_substrate; pfam03466
592021005205	dimerization interface [polypeptide binding]; other site
592021005206	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
592021005207	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021005208	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021005209	putative Zn2+ binding site [ion binding]; other site
592021005210	putative DNA binding site [nucleotide binding]; other site
592021005211	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
592021005212	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
592021005213	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
592021005214	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
592021005215	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
592021005216	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
592021005217	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
592021005218	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
592021005219	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021005220	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
592021005221	Walker A/P-loop; other site
592021005222	ATP binding site [chemical binding]; other site
592021005223	Q-loop/lid; other site
592021005224	ABC transporter signature motif; other site
592021005225	Walker B; other site
592021005226	D-loop; other site
592021005227	H-loop/switch region; other site
592021005228	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
592021005229	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021005230	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
592021005231	Walker A/P-loop; other site
592021005232	ATP binding site [chemical binding]; other site
592021005233	Q-loop/lid; other site
592021005234	ABC transporter signature motif; other site
592021005235	Walker B; other site
592021005236	D-loop; other site
592021005237	H-loop/switch region; other site
592021005238	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
592021005239	putative dimer interface [polypeptide binding]; other site
592021005240	catalytic triad [active]
592021005241	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021005242	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
592021005243	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
592021005244	dimer interface [polypeptide binding]; other site
592021005245	FMN binding site [chemical binding]; other site
592021005246	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021005247	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021005248	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021005249	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
592021005250	NlpC/P60 family; Region: NLPC_P60; pfam00877
592021005251	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021005252	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021005253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021005254	active site
592021005255	phosphorylation site [posttranslational modification]
592021005256	intermolecular recognition site; other site
592021005257	dimerization interface [polypeptide binding]; other site
592021005258	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021005259	DNA binding site [nucleotide binding]
592021005260	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021005261	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021005262	dimerization interface [polypeptide binding]; other site
592021005263	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021005264	dimer interface [polypeptide binding]; other site
592021005265	phosphorylation site [posttranslational modification]
592021005266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021005267	ATP binding site [chemical binding]; other site
592021005268	Mg2+ binding site [ion binding]; other site
592021005269	G-X-G motif; other site
592021005270	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
592021005271	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
592021005272	classical (c) SDRs; Region: SDR_c; cd05233
592021005273	NAD(P) binding site [chemical binding]; other site
592021005274	active site
592021005275	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
592021005276	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
592021005277	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
592021005278	NodB motif; other site
592021005279	active site
592021005280	catalytic site [active]
592021005281	metal binding site [ion binding]; metal-binding site
592021005282	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
592021005283	nudix motif; other site
592021005284	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
592021005285	homoserine dehydrogenase; Provisional; Region: PRK06349
592021005286	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
592021005287	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
592021005288	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
592021005289	threonine synthase; Reviewed; Region: PRK06721
592021005290	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
592021005291	homodimer interface [polypeptide binding]; other site
592021005292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021005293	catalytic residue [active]
592021005294	homoserine kinase; Provisional; Region: PRK01212
592021005295	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
592021005296	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
592021005297	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
592021005298	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
592021005299	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021005300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021005301	active site
592021005302	phosphorylation site [posttranslational modification]
592021005303	intermolecular recognition site; other site
592021005304	dimerization interface [polypeptide binding]; other site
592021005305	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021005306	DNA binding site [nucleotide binding]
592021005307	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021005308	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021005309	dimerization interface [polypeptide binding]; other site
592021005310	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021005311	dimer interface [polypeptide binding]; other site
592021005312	phosphorylation site [posttranslational modification]
592021005313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021005314	ATP binding site [chemical binding]; other site
592021005315	Mg2+ binding site [ion binding]; other site
592021005316	G-X-G motif; other site
592021005317	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
592021005318	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
592021005319	NodB motif; other site
592021005320	active site
592021005321	catalytic site [active]
592021005322	Zn binding site [ion binding]; other site
592021005323	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
592021005324	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
592021005325	MgtC family; Region: MgtC; pfam02308
592021005326	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021005327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005328	Coenzyme A binding pocket [chemical binding]; other site
592021005329	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
592021005330	IucA / IucC family; Region: IucA_IucC; pfam04183
592021005331	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
592021005332	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
592021005333	IucA / IucC family; Region: IucA_IucC; pfam04183
592021005334	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
592021005335	acyl-CoA synthetase; Validated; Region: PRK08308
592021005336	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
592021005337	acyl-activating enzyme (AAE) consensus motif; other site
592021005338	AMP binding site [chemical binding]; other site
592021005339	active site
592021005340	CoA binding site [chemical binding]; other site
592021005341	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
592021005342	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
592021005343	Lysine efflux permease [General function prediction only]; Region: COG1279
592021005344	Protein of unknown function (DUF3933); Region: DUF3933; pfam13069
592021005345	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
592021005346	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
592021005347	active site
592021005348	nucleophile elbow; other site
592021005349	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
592021005350	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
592021005351	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
592021005352	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
592021005353	nudix motif; other site
592021005354	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
592021005355	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
592021005356	homodimer interface [polypeptide binding]; other site
592021005357	NAD binding pocket [chemical binding]; other site
592021005358	ATP binding pocket [chemical binding]; other site
592021005359	Mg binding site [ion binding]; other site
592021005360	active-site loop [active]
592021005361	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
592021005362	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
592021005363	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
592021005364	active site
592021005365	catalytic residues [active]
592021005366	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021005367	dimerization interface [polypeptide binding]; other site
592021005368	putative DNA binding site [nucleotide binding]; other site
592021005369	putative Zn2+ binding site [ion binding]; other site
592021005370	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021005371	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021005372	active site
592021005373	catalytic tetrad [active]
592021005374	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
592021005375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021005376	putative substrate translocation pore; other site
592021005377	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
592021005378	Protein of unknown function (DUF664); Region: DUF664; pfam04978
592021005379	DinB superfamily; Region: DinB_2; pfam12867
592021005380	GTPase RsgA; Reviewed; Region: PRK01889
592021005381	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
592021005382	RNA binding site [nucleotide binding]; other site
592021005383	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
592021005384	GTPase/Zn-binding domain interface [polypeptide binding]; other site
592021005385	GTP/Mg2+ binding site [chemical binding]; other site
592021005386	G4 box; other site
592021005387	G5 box; other site
592021005388	G1 box; other site
592021005389	Switch I region; other site
592021005390	G2 box; other site
592021005391	G3 box; other site
592021005392	Switch II region; other site
592021005393	Tar ligand binding domain homologue; Region: TarH; pfam02203
592021005394	Cache domain; Region: Cache_1; pfam02743
592021005395	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
592021005396	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021005397	dimerization interface [polypeptide binding]; other site
592021005398	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021005399	dimer interface [polypeptide binding]; other site
592021005400	putative CheW interface [polypeptide binding]; other site
592021005401	Protein of unknown function (DUF3979); Region: DUF3979; pfam13141
592021005402	Uncharacterized membrane protein [Function unknown]; Region: COG3949
592021005403	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
592021005404	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
592021005405	dimerization interface [polypeptide binding]; other site
592021005406	DPS ferroxidase diiron center [ion binding]; other site
592021005407	ion pore; other site
592021005408	Protein of unknown function (DUF3939); Region: DUF3939; pfam13075
592021005409	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
592021005410	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
592021005411	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
592021005412	Protein of unknown function (DUF3896); Region: DUF3896; pfam13035
592021005413	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
592021005414	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
592021005415	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021005416	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021005417	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021005418	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021005419	active site
592021005420	catalytic tetrad [active]
592021005421	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
592021005422	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
592021005423	P-loop, Walker A motif; other site
592021005424	Base recognition motif; other site
592021005425	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
592021005426	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021005427	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005428	Coenzyme A binding pocket [chemical binding]; other site
592021005429	Replication-relaxation; Region: Replic_Relax; pfam13814
592021005430	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959
592021005431	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
592021005432	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
592021005433	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
592021005434	metal binding site [ion binding]; metal-binding site
592021005435	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
592021005436	NADH(P)-binding; Region: NAD_binding_10; pfam13460
592021005437	NAD binding site [chemical binding]; other site
592021005438	active site
592021005439	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
592021005440	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
592021005441	active site
592021005442	FMN binding site [chemical binding]; other site
592021005443	substrate binding site [chemical binding]; other site
592021005444	homotetramer interface [polypeptide binding]; other site
592021005445	catalytic residue [active]
592021005446	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
592021005447	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
592021005448	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
592021005449	DNA binding site [nucleotide binding]
592021005450	active site
592021005451	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
592021005452	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021005453	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021005454	peptide binding site [polypeptide binding]; other site
592021005455	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
592021005456	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
592021005457	active site
592021005458	metal binding site [ion binding]; metal-binding site
592021005459	short chain dehydrogenase; Provisional; Region: PRK08309
592021005460	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
592021005461	catalytic core [active]
592021005462	CotH protein; Region: CotH; pfam08757
592021005463	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
592021005464	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
592021005465	nudix motif; other site
592021005466	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
592021005467	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
592021005468	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
592021005469	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
592021005470	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
592021005471	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
592021005472	Cl binding site [ion binding]; other site
592021005473	oligomer interface [polypeptide binding]; other site
592021005474	Predicted permeases [General function prediction only]; Region: COG0701
592021005475	Predicted membrane protein [Function unknown]; Region: COG3689
592021005476	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
592021005477	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
592021005478	NADH(P)-binding; Region: NAD_binding_10; pfam13460
592021005479	NAD binding site [chemical binding]; other site
592021005480	substrate binding site [chemical binding]; other site
592021005481	putative active site [active]
592021005482	Protein of unknown function (DUF456); Region: DUF456; pfam04306
592021005483	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
592021005484	Domain of unknown function DUF21; Region: DUF21; pfam01595
592021005485	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
592021005486	Transporter associated domain; Region: CorC_HlyC; smart01091
592021005487	FOG: CBS domain [General function prediction only]; Region: COG0517
592021005488	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
592021005489	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
592021005490	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
592021005491	dimer interface [polypeptide binding]; other site
592021005492	putative tRNA-binding site [nucleotide binding]; other site
592021005493	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
592021005494	DinB superfamily; Region: DinB_2; pfam12867
592021005495	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
592021005496	stage II sporulation protein P; Region: spore_II_P; TIGR02867
592021005497	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021005498	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005499	Coenzyme A binding pocket [chemical binding]; other site
592021005500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021005501	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
592021005502	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
592021005503	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663
592021005504	nudix motif; other site
592021005505	amidase; Provisional; Region: PRK06828
592021005506	Amidase; Region: Amidase; pfam01425
592021005507	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021005508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021005509	putative substrate translocation pore; other site
592021005510	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
592021005511	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
592021005512	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
592021005513	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
592021005514	catalytic core [active]
592021005515	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021005516	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021005517	active site
592021005518	motif I; other site
592021005519	motif II; other site
592021005520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021005521	DinB superfamily; Region: DinB_2; pfam12867
592021005522	DinB family; Region: DinB; cl17821
592021005523	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
592021005524	alanine racemase; Reviewed; Region: alr; PRK00053
592021005525	active site
592021005526	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
592021005527	dimer interface [polypeptide binding]; other site
592021005528	substrate binding site [chemical binding]; other site
592021005529	catalytic residues [active]
592021005530	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021005531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021005532	S-adenosylmethionine binding site [chemical binding]; other site
592021005533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005534	Coenzyme A binding pocket [chemical binding]; other site
592021005535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005536	Coenzyme A binding pocket [chemical binding]; other site
592021005537	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
592021005538	active site
592021005539	ATP binding site [chemical binding]; other site
592021005540	substrate binding site [chemical binding]; other site
592021005541	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
592021005542	glycosyltransferase, MGT family; Region: MGT; TIGR01426
592021005543	active site
592021005544	TDP-binding site; other site
592021005545	acceptor substrate-binding pocket; other site
592021005546	homodimer interface [polypeptide binding]; other site
592021005547	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021005548	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021005549	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021005550	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
592021005551	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021005552	DNA-binding site [nucleotide binding]; DNA binding site
592021005553	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021005554	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021005555	homodimer interface [polypeptide binding]; other site
592021005556	catalytic residue [active]
592021005557	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005558	Coenzyme A binding pocket [chemical binding]; other site
592021005559	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021005560	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005561	Coenzyme A binding pocket [chemical binding]; other site
592021005562	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021005563	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021005564	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005565	Coenzyme A binding pocket [chemical binding]; other site
592021005566	Cupin domain; Region: Cupin_2; cl17218
592021005567	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
592021005568	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021005569	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021005570	S-adenosylmethionine binding site [chemical binding]; other site
592021005571	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
592021005572	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
592021005573	Potassium binding sites [ion binding]; other site
592021005574	Cesium cation binding sites [ion binding]; other site
592021005575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
592021005576	DEAD-like helicases superfamily; Region: DEXDc; smart00487
592021005577	ATP binding site [chemical binding]; other site
592021005578	putative Mg++ binding site [ion binding]; other site
592021005579	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021005580	nucleotide binding region [chemical binding]; other site
592021005581	ATP-binding site [chemical binding]; other site
592021005582	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
592021005583	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021005584	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
592021005585	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
592021005586	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
592021005587	NADP binding site [chemical binding]; other site
592021005588	dimer interface [polypeptide binding]; other site
592021005589	RNA polymerase sigma factor; Provisional; Region: PRK12543
592021005590	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021005591	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021005592	DNA binding residues [nucleotide binding]
592021005593	Domain of unknown function (DUF3600); Region: DUF3600; pfam12207
592021005594	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021005595	Protein of unknown function (DUF3925); Region: DUF3925; pfam13063
592021005596	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
592021005597	catalytic residues [active]
592021005598	dimer interface [polypeptide binding]; other site
592021005599	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
592021005600	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
592021005601	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
592021005602	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
592021005603	Protein of unknown function DUF58; Region: DUF58; pfam01882
592021005604	MoxR-like ATPases [General function prediction only]; Region: COG0714
592021005605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021005606	Walker A motif; other site
592021005607	ATP binding site [chemical binding]; other site
592021005608	Walker B motif; other site
592021005609	arginine finger; other site
592021005610	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
592021005611	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
592021005612	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
592021005613	[4Fe-4S] binding site [ion binding]; other site
592021005614	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
592021005615	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
592021005616	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
592021005617	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
592021005618	molybdopterin cofactor binding site; other site
592021005619	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
592021005620	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
592021005621	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
592021005622	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
592021005623	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
592021005624	Predicted transcriptional regulators [Transcription]; Region: COG1725
592021005625	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021005626	DNA-binding site [nucleotide binding]; DNA binding site
592021005627	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021005628	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021005629	Walker A/P-loop; other site
592021005630	ATP binding site [chemical binding]; other site
592021005631	Q-loop/lid; other site
592021005632	ABC transporter signature motif; other site
592021005633	Walker B; other site
592021005634	D-loop; other site
592021005635	H-loop/switch region; other site
592021005636	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
592021005637	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
592021005638	ligand binding site [chemical binding]; other site
592021005639	flexible hinge region; other site
592021005640	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
592021005641	putative switch regulator; other site
592021005642	non-specific DNA interactions [nucleotide binding]; other site
592021005643	DNA binding site [nucleotide binding]
592021005644	sequence specific DNA binding site [nucleotide binding]; other site
592021005645	putative cAMP binding site [chemical binding]; other site
592021005646	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
592021005647	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021005648	FeS/SAM binding site; other site
592021005649	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
592021005650	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
592021005651	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
592021005652	ATP binding site [chemical binding]; other site
592021005653	substrate interface [chemical binding]; other site
592021005654	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
592021005655	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
592021005656	dimer interface [polypeptide binding]; other site
592021005657	putative functional site; other site
592021005658	putative MPT binding site; other site
592021005659	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
592021005660	MoaE homodimer interface [polypeptide binding]; other site
592021005661	MoaD interaction [polypeptide binding]; other site
592021005662	active site residues [active]
592021005663	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
592021005664	MoaE interaction surface [polypeptide binding]; other site
592021005665	MoeB interaction surface [polypeptide binding]; other site
592021005666	thiocarboxylated glycine; other site
592021005667	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
592021005668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021005669	putative substrate translocation pore; other site
592021005670	Predicted permeases [General function prediction only]; Region: COG0679
592021005671	precorrin-2 dehydrogenase; Validated; Region: PRK06719
592021005672	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
592021005673	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
592021005674	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
592021005675	putative active site [active]
592021005676	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
592021005677	putative active site [active]
592021005678	bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168
592021005679	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
592021005680	active site
592021005681	SAM binding site [chemical binding]; other site
592021005682	homodimer interface [polypeptide binding]; other site
592021005683	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
592021005684	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
592021005685	[2Fe-2S] cluster binding site [ion binding]; other site
592021005686	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
592021005687	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021005688	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021005689	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
592021005690	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
592021005691	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
592021005692	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
592021005693	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
592021005694	Hemerythrin-like domain; Region: Hr-like; cd12108
592021005695	Fe binding site [ion binding]; other site
592021005696	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
592021005697	N-acetyltransferase; Region: Acetyltransf_2; cl00949
592021005698	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
592021005699	PGAP1-like protein; Region: PGAP1; pfam07819
592021005700	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
592021005701	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
592021005702	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021005703	Zn2+ binding site [ion binding]; other site
592021005704	Mg2+ binding site [ion binding]; other site
592021005705	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
592021005706	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
592021005707	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021005708	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021005709	ABC transporter; Region: ABC_tran_2; pfam12848
592021005710	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021005711	Bax inhibitor 1 like; Region: BaxI_1; cl17691
592021005712	Domain of unknown function (DUF4318); Region: DUF4318; pfam14201
592021005713	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
592021005714	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
592021005715	dimer interface [polypeptide binding]; other site
592021005716	ssDNA binding site [nucleotide binding]; other site
592021005717	tetramer (dimer of dimers) interface [polypeptide binding]; other site
592021005718	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021005719	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021005720	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
592021005721	Virulence factor; Region: Virulence_fact; pfam13769
592021005722	HEAT repeats; Region: HEAT_2; pfam13646
592021005723	HEAT repeats; Region: HEAT_2; pfam13646
592021005724	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
592021005725	Protein of unknown function, DUF393; Region: DUF393; pfam04134
592021005726	Disulphide isomerase; Region: Disulph_isomer; pfam06491
592021005727	Brix domain; Region: Brix; cl00935
592021005728	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
592021005729	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
592021005730	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
592021005731	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
592021005732	active site
592021005733	HIGH motif; other site
592021005734	KMSK motif region; other site
592021005735	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
592021005736	tRNA binding surface [nucleotide binding]; other site
592021005737	anticodon binding site; other site
592021005738	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
592021005739	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021005740	Methyltransferase domain; Region: Methyltransf_12; pfam08242
592021005741	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
592021005742	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
592021005743	HIGH motif; other site
592021005744	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
592021005745	active site
592021005746	KMSKS motif; other site
592021005747	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
592021005748	tRNA binding surface [nucleotide binding]; other site
592021005749	anticodon binding site; other site
592021005750	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
592021005751	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
592021005752	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
592021005753	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
592021005754	Zn binding site [ion binding]; other site
592021005755	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
592021005756	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
592021005757	Dimer interface [polypeptide binding]; other site
592021005758	anticodon binding site; other site
592021005759	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
592021005760	homodimer interface [polypeptide binding]; other site
592021005761	motif 1; other site
592021005762	motif 2; other site
592021005763	active site
592021005764	motif 3; other site
592021005765	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
592021005766	metal ion-dependent adhesion site (MIDAS); other site
592021005767	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
592021005768	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
592021005769	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
592021005770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021005771	Walker A motif; other site
592021005772	ATP binding site [chemical binding]; other site
592021005773	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
592021005774	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
592021005775	SseB protein; Region: SseB; cl06279
592021005776	Proteins of 100 residues with WXG; Region: WXG100; cl02005
592021005777	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
592021005778	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
592021005779	Immunity protein Imm3; Region: Imm3; pfam14425
592021005780	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
592021005781	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
592021005782	catalytic residues [active]
592021005783	catalytic nucleophile [active]
592021005784	Recombinase; Region: Recombinase; pfam07508
592021005785	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
592021005786	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
592021005787	glycerate kinase; Region: TIGR00045
592021005788	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
592021005789	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
592021005790	transmembrane helices; other site
592021005791	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021005792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021005793	active site
592021005794	phosphorylation site [posttranslational modification]
592021005795	intermolecular recognition site; other site
592021005796	dimerization interface [polypeptide binding]; other site
592021005797	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021005798	DNA binding site [nucleotide binding]
592021005799	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021005800	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021005801	dimerization interface [polypeptide binding]; other site
592021005802	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021005803	dimer interface [polypeptide binding]; other site
592021005804	phosphorylation site [posttranslational modification]
592021005805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021005806	ATP binding site [chemical binding]; other site
592021005807	Mg2+ binding site [ion binding]; other site
592021005808	G-X-G motif; other site
592021005809	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
592021005810	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
592021005811	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
592021005812	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
592021005813	Na2 binding site [ion binding]; other site
592021005814	putative substrate binding site 1 [chemical binding]; other site
592021005815	Na binding site 1 [ion binding]; other site
592021005816	putative substrate binding site 2 [chemical binding]; other site
592021005817	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021005818	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
592021005819	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
592021005820	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
592021005821	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021005822	motif II; other site
592021005823	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
592021005824	fructuronate transporter; Provisional; Region: PRK10034; cl15264
592021005825	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
592021005826	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
592021005827	active site
592021005828	NAD binding site [chemical binding]; other site
592021005829	metal binding site [ion binding]; metal-binding site
592021005830	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
592021005831	aspartate racemase; Region: asp_race; TIGR00035
592021005832	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
592021005833	homodimer interaction site [polypeptide binding]; other site
592021005834	cofactor binding site; other site
592021005835	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021005836	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005837	Coenzyme A binding pocket [chemical binding]; other site
592021005838	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
592021005839	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021005840	Coenzyme A binding pocket [chemical binding]; other site
592021005841	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
592021005842	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021005843	Walker A/P-loop; other site
592021005844	ATP binding site [chemical binding]; other site
592021005845	Q-loop/lid; other site
592021005846	ABC transporter signature motif; other site
592021005847	Walker B; other site
592021005848	D-loop; other site
592021005849	H-loop/switch region; other site
592021005850	YpjP-like protein; Region: YpjP; pfam14005
592021005851	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
592021005852	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021005853	motif II; other site
592021005854	hypothetical protein; Provisional; Region: PRK06724
592021005855	active site
592021005856	Phosphotransferase enzyme family; Region: APH; pfam01636
592021005857	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
592021005858	active site
592021005859	ATP binding site [chemical binding]; other site
592021005860	substrate binding site [chemical binding]; other site
592021005861	Peptidase family S41; Region: Peptidase_S41; pfam03572
592021005862	Active site serine [active]
592021005863	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021005864	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021005865	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
592021005866	thymidylate synthase; Region: thym_sym; TIGR03284
592021005867	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
592021005868	dimerization interface [polypeptide binding]; other site
592021005869	active site
592021005870	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
592021005871	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
592021005872	folate binding site [chemical binding]; other site
592021005873	NADP+ binding site [chemical binding]; other site
592021005874	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
592021005875	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021005876	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
592021005877	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021005878	azoreductase; Reviewed; Region: PRK00170
592021005879	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
592021005880	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
592021005881	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
592021005882	putative acyl-acceptor binding pocket; other site
592021005883	Haemolysin-III related; Region: HlyIII; cl03831
592021005884	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
592021005885	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
592021005886	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
592021005887	Protein of unknown function (DUF2535); Region: DUF2535; pfam10751
592021005888	EDD domain protein, DegV family; Region: DegV; TIGR00762
592021005889	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
592021005890	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
592021005891	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
592021005892	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
592021005893	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
592021005894	Cu(I) binding site [ion binding]; other site
592021005895	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
592021005896	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
592021005897	putative dimer interface [polypeptide binding]; other site
592021005898	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
592021005899	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
592021005900	active site
592021005901	dimer interface [polypeptide binding]; other site
592021005902	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
592021005903	Ligand Binding Site [chemical binding]; other site
592021005904	Molecular Tunnel; other site
592021005905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021005906	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
592021005907	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
592021005908	siderophore binding site; other site
592021005909	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
592021005910	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
592021005911	homodimer interface [polypeptide binding]; other site
592021005912	substrate-cofactor binding pocket; other site
592021005913	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021005914	catalytic residue [active]
592021005915	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
592021005916	FMN binding site [chemical binding]; other site
592021005917	dimer interface [polypeptide binding]; other site
592021005918	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
592021005919	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
592021005920	putative dimer interface [polypeptide binding]; other site
592021005921	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
592021005922	Mechanosensitive ion channel; Region: MS_channel; pfam00924
592021005923	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
592021005924	GAF domain; Region: GAF; pfam01590
592021005925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
592021005926	Histidine kinase; Region: HisKA_3; pfam07730
592021005927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021005928	ATP binding site [chemical binding]; other site
592021005929	Mg2+ binding site [ion binding]; other site
592021005930	G-X-G motif; other site
592021005931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
592021005932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021005933	active site
592021005934	phosphorylation site [posttranslational modification]
592021005935	intermolecular recognition site; other site
592021005936	dimerization interface [polypeptide binding]; other site
592021005937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
592021005938	DNA binding residues [nucleotide binding]
592021005939	dimerization interface [polypeptide binding]; other site
592021005940	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
592021005941	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
592021005942	NAD binding site [chemical binding]; other site
592021005943	substrate binding site [chemical binding]; other site
592021005944	catalytic Zn binding site [ion binding]; other site
592021005945	tetramer interface [polypeptide binding]; other site
592021005946	structural Zn binding site [ion binding]; other site
592021005947	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
592021005948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021005949	dimer interface [polypeptide binding]; other site
592021005950	conserved gate region; other site
592021005951	ABC-ATPase subunit interface; other site
592021005952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
592021005953	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
592021005954	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
592021005955	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021005956	active site
592021005957	Predicted flavoprotein [General function prediction only]; Region: COG0431
592021005958	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
592021005959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021005960	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021005961	putative substrate translocation pore; other site
592021005962	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
592021005963	Uncharacterized conserved protein [Function unknown]; Region: COG1434
592021005964	putative active site [active]
592021005965	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
592021005966	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
592021005967	Walker A/P-loop; other site
592021005968	ATP binding site [chemical binding]; other site
592021005969	Q-loop/lid; other site
592021005970	ABC transporter signature motif; other site
592021005971	Walker B; other site
592021005972	D-loop; other site
592021005973	H-loop/switch region; other site
592021005974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021005975	dimer interface [polypeptide binding]; other site
592021005976	conserved gate region; other site
592021005977	ABC-ATPase subunit interface; other site
592021005978	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
592021005979	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
592021005980	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
592021005981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
592021005982	Protein of unknown function (DUF524); Region: DUF524; pfam04411
592021005983	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
592021005984	Helix-turn-helix domain; Region: HTH_17; cl17695
592021005985	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
592021005986	Domain of unknown function DUF21; Region: DUF21; pfam01595
592021005987	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
592021005988	Transporter associated domain; Region: CorC_HlyC; smart01091
592021005989	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
592021005990	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
592021005991	NAD(P) binding site [chemical binding]; other site
592021005992	catalytic residues [active]
592021005993	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
592021005994	Histidine kinase N terminal; Region: HisK_N; pfam09385
592021005995	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021005996	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021005997	dimer interface [polypeptide binding]; other site
592021005998	phosphorylation site [posttranslational modification]
592021005999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021006000	ATP binding site [chemical binding]; other site
592021006001	Mg2+ binding site [ion binding]; other site
592021006002	G-X-G motif; other site
592021006003	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
592021006004	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
592021006005	hypothetical protein; Provisional; Region: PRK06917
592021006006	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021006007	inhibitor-cofactor binding pocket; inhibition site
592021006008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021006009	catalytic residue [active]
592021006010	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
592021006011	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
592021006012	acetylornithine deacetylase; Validated; Region: PRK06915
592021006013	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
592021006014	metal binding site [ion binding]; metal-binding site
592021006015	dimer interface [polypeptide binding]; other site
592021006016	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
592021006017	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021006018	PAS fold; Region: PAS_4; pfam08448
592021006019	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
592021006020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021006021	Walker A motif; other site
592021006022	ATP binding site [chemical binding]; other site
592021006023	Walker B motif; other site
592021006024	arginine finger; other site
592021006025	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
592021006026	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
592021006027	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021006028	FeS/SAM binding site; other site
592021006029	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
592021006030	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
592021006031	toxin interface [polypeptide binding]; other site
592021006032	Zn binding site [ion binding]; other site
592021006033	hypothetical protein; Provisional; Region: PRK13672
592021006034	Protein of unknown function (DUF3930); Region: DUF3930; pfam13067
592021006035	YozD-like protein; Region: YozD; pfam14162
592021006036	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
592021006037	Catalytic domain of Protein Kinases; Region: PKc; cd00180
592021006038	active site
592021006039	ATP binding site [chemical binding]; other site
592021006040	substrate binding site [chemical binding]; other site
592021006041	activation loop (A-loop); other site
592021006042	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
592021006043	SpoOM protein; Region: Spo0M; pfam07070
592021006044	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
592021006045	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
592021006046	active site
592021006047	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
592021006048	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
592021006049	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
592021006050	catalytic residues [active]
592021006051	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
592021006052	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
592021006053	DNA binding site [nucleotide binding]
592021006054	active site
592021006055	Int/Topo IB signature motif; other site
592021006056	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
592021006057	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
592021006058	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
592021006059	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
592021006060	putative active site [active]
592021006061	putative active site [active]
592021006062	catalytic site [active]
592021006063	catalytic site [active]
592021006064	Restriction endonuclease; Region: Mrr_cat; pfam04471
592021006065	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021006066	non-specific DNA binding site [nucleotide binding]; other site
592021006067	salt bridge; other site
592021006068	sequence-specific DNA binding site [nucleotide binding]; other site
592021006069	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
592021006070	Replication-relaxation; Region: Replic_Relax; pfam13814
592021006071	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
592021006072	homotrimer interaction site [polypeptide binding]; other site
592021006073	putative active site [active]
592021006074	Protein of unknown function (DUF3956); Region: DUF3956; pfam13104
592021006075	CHRD domain; Region: CHRD; pfam07452
592021006076	C1q domain; Region: C1q; cl17543
592021006077	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
592021006078	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
592021006079	YolD-like protein; Region: YolD; pfam08863
592021006080	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
592021006081	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
592021006082	Transglycosylase; Region: Transgly; pfam00912
592021006083	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
592021006084	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021006085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006086	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021006087	putative substrate translocation pore; other site
592021006088	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
592021006089	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
592021006090	dimer interface [polypeptide binding]; other site
592021006091	Citrate synthase; Region: Citrate_synt; pfam00285
592021006092	active site
592021006093	coenzyme A binding site [chemical binding]; other site
592021006094	citrylCoA binding site [chemical binding]; other site
592021006095	oxalacetate/citrate binding site [chemical binding]; other site
592021006096	catalytic triad [active]
592021006097	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
592021006098	2-methylcitrate dehydratase; Region: prpD; TIGR02330
592021006099	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
592021006100	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
592021006101	tetramer interface [polypeptide binding]; other site
592021006102	active site
592021006103	Mg2+/Mn2+ binding site [ion binding]; other site
592021006104	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
592021006105	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
592021006106	active site
592021006107	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
592021006108	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
592021006109	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
592021006110	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
592021006111	tetrameric interface [polypeptide binding]; other site
592021006112	NAD binding site [chemical binding]; other site
592021006113	catalytic residues [active]
592021006114	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
592021006115	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
592021006116	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
592021006117	substrate binding site [chemical binding]; other site
592021006118	oxyanion hole (OAH) forming residues; other site
592021006119	trimer interface [polypeptide binding]; other site
592021006120	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
592021006121	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
592021006122	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
592021006123	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
592021006124	active site
592021006125	metal binding site [ion binding]; metal-binding site
592021006126	DNA binding site [nucleotide binding]
592021006127	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
592021006128	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
592021006129	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
592021006130	Walker A/P-loop; other site
592021006131	ATP binding site [chemical binding]; other site
592021006132	Q-loop/lid; other site
592021006133	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
592021006134	ABC transporter signature motif; other site
592021006135	Walker B; other site
592021006136	D-loop; other site
592021006137	H-loop/switch region; other site
592021006138	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021006139	dimerization interface [polypeptide binding]; other site
592021006140	putative DNA binding site [nucleotide binding]; other site
592021006141	putative Zn2+ binding site [ion binding]; other site
592021006142	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
592021006143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006144	putative substrate translocation pore; other site
592021006145	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
592021006146	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
592021006147	putative NAD(P) binding site [chemical binding]; other site
592021006148	active site
592021006149	isochorismate synthase DhbC; Validated; Region: PRK06923
592021006150	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
592021006151	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
592021006152	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
592021006153	acyl-activating enzyme (AAE) consensus motif; other site
592021006154	active site
592021006155	AMP binding site [chemical binding]; other site
592021006156	substrate binding site [chemical binding]; other site
592021006157	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
592021006158	hydrophobic substrate binding pocket; other site
592021006159	Isochorismatase family; Region: Isochorismatase; pfam00857
592021006160	active site
592021006161	conserved cis-peptide bond; other site
592021006162	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
592021006163	Condensation domain; Region: Condensation; pfam00668
592021006164	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
592021006165	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
592021006166	acyl-activating enzyme (AAE) consensus motif; other site
592021006167	AMP binding site [chemical binding]; other site
592021006168	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
592021006169	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
592021006170	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
592021006171	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
592021006172	acyl-activating enzyme (AAE) consensus motif; other site
592021006173	AMP binding site [chemical binding]; other site
592021006174	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
592021006175	MbtH-like protein; Region: MbtH; cl01279
592021006176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006177	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021006178	putative substrate translocation pore; other site
592021006179	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
592021006180	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
592021006181	Chorismate lyase; Region: Chor_lyase; cl01230
592021006182	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
592021006183	IHF dimer interface [polypeptide binding]; other site
592021006184	IHF - DNA interface [nucleotide binding]; other site
592021006185	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
592021006186	DinB family; Region: DinB; cl17821
592021006187	DinB superfamily; Region: DinB_2; pfam12867
592021006188	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
592021006189	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
592021006190	active site
592021006191	catalytic triad [active]
592021006192	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
592021006193	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
592021006194	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
592021006195	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
592021006196	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021006197	RNA binding surface [nucleotide binding]; other site
592021006198	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
592021006199	probable active site [active]
592021006200	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
592021006201	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
592021006202	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
592021006203	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
592021006204	active site
592021006205	dimer interface [polypeptide binding]; other site
592021006206	motif 1; other site
592021006207	motif 2; other site
592021006208	motif 3; other site
592021006209	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
592021006210	anticodon binding site; other site
592021006211	FtsX-like permease family; Region: FtsX; pfam02687
592021006212	Protein of unknown function (DUF867); Region: DUF867; cl01713
592021006213	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021006214	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
592021006215	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
592021006216	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021006217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006218	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
592021006219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021006220	dimer interface [polypeptide binding]; other site
592021006221	conserved gate region; other site
592021006222	ABC-ATPase subunit interface; other site
592021006223	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
592021006224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021006225	S-adenosylmethionine binding site [chemical binding]; other site
592021006226	Protein of unknown function (DUF2185); Region: DUF2185; pfam09951
592021006227	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021006228	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
592021006229	active site
592021006230	dimerization interface [polypeptide binding]; other site
592021006231	Protein of unknown function (DUF2441); Region: DUF2441; pfam10386
592021006232	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
592021006233	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021006234	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021006235	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021006236	MMPL family; Region: MMPL; pfam03176
592021006237	MMPL family; Region: MMPL; pfam03176
592021006238	Protein of unknown function (DUF4021); Region: DUF4021; pfam13213
592021006239	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
592021006240	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
592021006241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006242	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
592021006243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021006244	Coenzyme A binding pocket [chemical binding]; other site
592021006245	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021006246	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006247	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021006248	Coenzyme A binding pocket [chemical binding]; other site
592021006249	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
592021006250	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
592021006251	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
592021006252	putative acetyltransferase YhhY; Provisional; Region: PRK10140
592021006253	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006254	Coenzyme A binding pocket [chemical binding]; other site
592021006255	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021006256	EamA-like transporter family; Region: EamA; pfam00892
592021006257	EamA-like transporter family; Region: EamA; pfam00892
592021006258	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
592021006259	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021006260	non-specific DNA binding site [nucleotide binding]; other site
592021006261	salt bridge; other site
592021006262	sequence-specific DNA binding site [nucleotide binding]; other site
592021006263	Cupin domain; Region: Cupin_2; pfam07883
592021006264	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
592021006265	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021006266	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
592021006267	protoporphyrinogen oxidase; Provisional; Region: PRK12416
592021006268	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
592021006269	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021006270	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021006271	Cold-inducible protein YdjO; Region: YdjO; pfam14169
592021006272	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
592021006273	DNA-binding site [nucleotide binding]; DNA binding site
592021006274	RNA-binding motif; other site
592021006275	AAA domain; Region: AAA_17; pfam13207
592021006276	AAA domain; Region: AAA_18; pfam13238
592021006277	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
592021006278	active site
592021006279	metal binding site [ion binding]; metal-binding site
592021006280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021006281	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021006282	active site
592021006283	motif I; other site
592021006284	motif II; other site
592021006285	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021006286	motif II; other site
592021006287	hypothetical protein; Provisional; Region: PRK06770
592021006288	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
592021006289	Protein of unknown function (DUF3956); Region: DUF3956; pfam13104
592021006290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021006291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021006292	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021006293	dimerization interface [polypeptide binding]; other site
592021006294	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728
592021006295	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
592021006296	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
592021006297	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
592021006298	active site
592021006299	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
592021006300	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
592021006301	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021006302	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021006303	dimerization interface [polypeptide binding]; other site
592021006304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
592021006305	MOSC domain; Region: MOSC; pfam03473
592021006306	3-alpha domain; Region: 3-alpha; pfam03475
592021006307	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006308	Coenzyme A binding pocket [chemical binding]; other site
592021006309	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
592021006310	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
592021006311	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021006312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021006313	Walker A/P-loop; other site
592021006314	ATP binding site [chemical binding]; other site
592021006315	Q-loop/lid; other site
592021006316	ABC transporter signature motif; other site
592021006317	Walker B; other site
592021006318	D-loop; other site
592021006319	H-loop/switch region; other site
592021006320	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
592021006321	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021006322	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
592021006323	Walker A/P-loop; other site
592021006324	ATP binding site [chemical binding]; other site
592021006325	Q-loop/lid; other site
592021006326	ABC transporter signature motif; other site
592021006327	Walker B; other site
592021006328	D-loop; other site
592021006329	H-loop/switch region; other site
592021006330	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
592021006331	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
592021006332	active site
592021006333	metal binding site [ion binding]; metal-binding site
592021006334	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
592021006335	LysE type translocator; Region: LysE; cl00565
592021006336	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
592021006337	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021006338	non-specific DNA binding site [nucleotide binding]; other site
592021006339	salt bridge; other site
592021006340	sequence-specific DNA binding site [nucleotide binding]; other site
592021006341	Cupin domain; Region: Cupin_2; pfam07883
592021006342	BclB C-terminal domain; Region: exospore_TM; TIGR03721
592021006343	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
592021006344	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
592021006345	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
592021006346	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021006347	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
592021006348	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021006349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021006350	S-adenosylmethionine binding site [chemical binding]; other site
592021006351	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
592021006352	Domain of unknown function (DUF3974); Region: DUF3974; pfam13120
592021006353	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
592021006354	active site
592021006355	P-loop; other site
592021006356	phosphorylation site [posttranslational modification]
592021006357	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
592021006358	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
592021006359	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
592021006360	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
592021006361	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
592021006362	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
592021006363	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
592021006364	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
592021006365	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021006366	catalytic residue [active]
592021006367	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
592021006368	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
592021006369	tetramer interface [polypeptide binding]; other site
592021006370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021006371	catalytic residue [active]
592021006372	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
592021006373	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
592021006374	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
592021006375	ATP binding site [chemical binding]; other site
592021006376	Mg++ binding site [ion binding]; other site
592021006377	motif III; other site
592021006378	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021006379	nucleotide binding region [chemical binding]; other site
592021006380	ATP-binding site [chemical binding]; other site
592021006381	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021006382	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021006383	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021006384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
592021006385	FtsX-like permease family; Region: FtsX; pfam02687
592021006386	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021006387	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021006388	Walker A/P-loop; other site
592021006389	ATP binding site [chemical binding]; other site
592021006390	Q-loop/lid; other site
592021006391	ABC transporter signature motif; other site
592021006392	Walker B; other site
592021006393	D-loop; other site
592021006394	H-loop/switch region; other site
592021006395	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021006396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021006397	S-adenosylmethionine binding site [chemical binding]; other site
592021006398	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
592021006399	dimer interface [polypeptide binding]; other site
592021006400	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021006401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021006402	S-adenosylmethionine binding site [chemical binding]; other site
592021006403	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
592021006404	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
592021006405	dimer interface [polypeptide binding]; other site
592021006406	PYR/PP interface [polypeptide binding]; other site
592021006407	TPP binding site [chemical binding]; other site
592021006408	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
592021006409	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
592021006410	TPP-binding site [chemical binding]; other site
592021006411	dimer interface [polypeptide binding]; other site
592021006412	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021006413	MarR family; Region: MarR_2; pfam12802
592021006414	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
592021006415	catalytic core [active]
592021006416	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
592021006417	Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171
592021006418	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
592021006419	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
592021006420	metal binding site [ion binding]; metal-binding site
592021006421	dimer interface [polypeptide binding]; other site
592021006422	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
592021006423	active site
592021006424	catalytic triad [active]
592021006425	oxyanion hole [active]
592021006426	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
592021006427	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021006428	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021006429	DNA binding residues [nucleotide binding]
592021006430	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
592021006431	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021006432	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021006433	beta-lactamase TEM; Provisional; Region: PRK15442
592021006434	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
592021006435	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
592021006436	active site
592021006437	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021006438	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021006439	DNA binding site [nucleotide binding]
592021006440	domain linker motif; other site
592021006441	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
592021006442	ligand binding site [chemical binding]; other site
592021006443	dimerization interface [polypeptide binding]; other site
592021006444	polyol permease family; Region: 2A0118; TIGR00897
592021006445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006446	putative substrate translocation pore; other site
592021006447	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
592021006448	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
592021006449	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
592021006450	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
592021006451	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
592021006452	substrate binding site [chemical binding]; other site
592021006453	ATP binding site [chemical binding]; other site
592021006454	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
592021006455	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
592021006456	tetrameric interface [polypeptide binding]; other site
592021006457	NAD binding site [chemical binding]; other site
592021006458	catalytic residues [active]
592021006459	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
592021006460	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
592021006461	PYR/PP interface [polypeptide binding]; other site
592021006462	dimer interface [polypeptide binding]; other site
592021006463	TPP binding site [chemical binding]; other site
592021006464	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
592021006465	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
592021006466	TPP-binding site; other site
592021006467	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
592021006468	intersubunit interface [polypeptide binding]; other site
592021006469	active site
592021006470	zinc binding site [ion binding]; other site
592021006471	Na+ binding site [ion binding]; other site
592021006472	KduI/IolB family; Region: KduI; pfam04962
592021006473	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021006474	TPR motif; other site
592021006475	binding surface
592021006476	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021006477	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021006478	salt bridge; other site
592021006479	non-specific DNA binding site [nucleotide binding]; other site
592021006480	sequence-specific DNA binding site [nucleotide binding]; other site
592021006481	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
592021006482	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
592021006483	S-layer homology domain; Region: SLH; pfam00395
592021006484	S-layer homology domain; Region: SLH; pfam00395
592021006485	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
592021006486	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
592021006487	active site
592021006488	metal binding site [ion binding]; metal-binding site
592021006489	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021006490	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021006491	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
592021006492	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021006493	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021006494	PAS fold; Region: PAS_4; pfam08448
592021006495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021006496	putative active site [active]
592021006497	heme pocket [chemical binding]; other site
592021006498	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
592021006499	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021006500	metal binding site [ion binding]; metal-binding site
592021006501	active site
592021006502	I-site; other site
592021006503	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
592021006504	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021006505	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021006506	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
592021006507	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
592021006508	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
592021006509	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021006510	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
592021006511	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
592021006512	active site residue [active]
592021006513	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
592021006514	active site residue [active]
592021006515	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
592021006516	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
592021006517	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021006518	Walker A/P-loop; other site
592021006519	ATP binding site [chemical binding]; other site
592021006520	Q-loop/lid; other site
592021006521	ABC transporter signature motif; other site
592021006522	Walker B; other site
592021006523	D-loop; other site
592021006524	H-loop/switch region; other site
592021006525	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
592021006526	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
592021006527	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021006528	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021006529	Protein of unknown function (DUF523); Region: DUF523; pfam04463
592021006530	Uncharacterized conserved protein [Function unknown]; Region: COG3272
592021006531	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
592021006532	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
592021006533	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
592021006534	FAD binding site [chemical binding]; other site
592021006535	homotetramer interface [polypeptide binding]; other site
592021006536	substrate binding pocket [chemical binding]; other site
592021006537	catalytic base [active]
592021006538	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
592021006539	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
592021006540	ATP-grasp domain; Region: ATP-grasp_4; cl17255
592021006541	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
592021006542	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
592021006543	carboxyltransferase (CT) interaction site; other site
592021006544	biotinylation site [posttranslational modification]; other site
592021006545	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
592021006546	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
592021006547	active site
592021006548	catalytic residues [active]
592021006549	metal binding site [ion binding]; metal-binding site
592021006550	enoyl-CoA hydratase; Provisional; Region: PRK07657
592021006551	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
592021006552	substrate binding site [chemical binding]; other site
592021006553	oxyanion hole (OAH) forming residues; other site
592021006554	trimer interface [polypeptide binding]; other site
592021006555	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
592021006556	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
592021006557	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
592021006558	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
592021006559	acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188
592021006560	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
592021006561	acyl-activating enzyme (AAE) consensus motif; other site
592021006562	putative AMP binding site [chemical binding]; other site
592021006563	putative active site [active]
592021006564	putative CoA binding site [chemical binding]; other site
592021006565	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021006566	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006567	Coenzyme A binding pocket [chemical binding]; other site
592021006568	hypothetical protein; Provisional; Region: PRK08233
592021006569	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
592021006570	active site
592021006571	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021006572	DinB family; Region: DinB; cl17821
592021006573	DinB superfamily; Region: DinB_2; pfam12867
592021006574	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
592021006575	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021006576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021006577	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021006578	dimer interface [polypeptide binding]; other site
592021006579	phosphorylation site [posttranslational modification]
592021006580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021006581	ATP binding site [chemical binding]; other site
592021006582	Mg2+ binding site [ion binding]; other site
592021006583	G-X-G motif; other site
592021006584	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021006585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021006586	active site
592021006587	phosphorylation site [posttranslational modification]
592021006588	intermolecular recognition site; other site
592021006589	dimerization interface [polypeptide binding]; other site
592021006590	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021006591	DNA binding site [nucleotide binding]
592021006592	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021006593	Zn2+ binding site [ion binding]; other site
592021006594	Mg2+ binding site [ion binding]; other site
592021006595	S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714
592021006596	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
592021006597	NADH(P)-binding; Region: NAD_binding_10; pfam13460
592021006598	NAD binding site [chemical binding]; other site
592021006599	substrate binding site [chemical binding]; other site
592021006600	putative active site [active]
592021006601	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006602	Coenzyme A binding pocket [chemical binding]; other site
592021006603	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006604	Coenzyme A binding pocket [chemical binding]; other site
592021006605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
592021006606	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
592021006607	putative hydrophobic ligand binding site [chemical binding]; other site
592021006608	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021006609	AAA domain; Region: AAA_21; pfam13304
592021006610	Walker A/P-loop; other site
592021006611	ATP binding site [chemical binding]; other site
592021006612	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021006613	ABC transporter signature motif; other site
592021006614	Walker B; other site
592021006615	D-loop; other site
592021006616	H-loop/switch region; other site
592021006617	ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238
592021006618	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
592021006619	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
592021006620	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021006621	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
592021006622	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021006623	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021006624	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
592021006625	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021006626	DNA binding residues [nucleotide binding]
592021006627	drug binding residues [chemical binding]; other site
592021006628	dimer interface [polypeptide binding]; other site
592021006629	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
592021006630	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021006631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006632	putative substrate translocation pore; other site
592021006633	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
592021006634	nudix motif; other site
592021006635	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
592021006636	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
592021006637	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
592021006638	Phosphotransferase enzyme family; Region: APH; pfam01636
592021006639	active site
592021006640	substrate binding site [chemical binding]; other site
592021006641	ATP binding site [chemical binding]; other site
592021006642	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
592021006643	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021006644	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
592021006645	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
592021006646	active site
592021006647	Zn binding site [ion binding]; other site
592021006648	Protein of unknown function (DUF4030); Region: DUF4030; pfam13222
592021006649	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
592021006650	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021006651	DNA-binding site [nucleotide binding]; DNA binding site
592021006652	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021006653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021006654	homodimer interface [polypeptide binding]; other site
592021006655	catalytic residue [active]
592021006656	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
592021006657	Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240
592021006658	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
592021006659	putative NAD(P) binding site [chemical binding]; other site
592021006660	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021006661	S-adenosylmethionine binding site [chemical binding]; other site
592021006662	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021006663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021006664	S-adenosylmethionine binding site [chemical binding]; other site
592021006665	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
592021006666	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
592021006667	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021006668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021006669	active site
592021006670	phosphorylation site [posttranslational modification]
592021006671	intermolecular recognition site; other site
592021006672	dimerization interface [polypeptide binding]; other site
592021006673	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021006674	DNA binding site [nucleotide binding]
592021006675	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
592021006676	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021006677	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021006678	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
592021006679	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021006680	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021006681	Walker A/P-loop; other site
592021006682	ATP binding site [chemical binding]; other site
592021006683	Q-loop/lid; other site
592021006684	ABC transporter signature motif; other site
592021006685	Walker B; other site
592021006686	D-loop; other site
592021006687	H-loop/switch region; other site
592021006688	hypothetical protein; Provisional; Region: PRK06760
592021006689	Protein of unknown function (DUF3914); Region: DUF3914; pfam13053
592021006690	homoserine dehydrogenase; Validated; Region: PRK06813
592021006691	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
592021006692	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
592021006693	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
592021006694	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021006695	DNA-binding site [nucleotide binding]; DNA binding site
592021006696	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021006697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021006698	homodimer interface [polypeptide binding]; other site
592021006699	catalytic residue [active]
592021006700	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
592021006701	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
592021006702	ATP-grasp domain; Region: ATP-grasp_4; cl17255
592021006703	Putative transcription activator [Transcription]; Region: TenA; COG0819
592021006704	ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111
592021006705	Protein of unknown function (DUF3962); Region: DUF3962; pfam13111
592021006706	Domain of unknown function (DUF3893); Region: DUF3893; pfam13032
592021006707	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
592021006708	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
592021006709	Protein of unknown function; Region: DUF3658; pfam12395
592021006710	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
592021006711	Cytochrome P450; Region: p450; cl12078
592021006712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006713	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021006714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006715	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
592021006716	trimer interface [polypeptide binding]; other site
592021006717	active site
592021006718	substrate binding site [chemical binding]; other site
592021006719	CoA binding site [chemical binding]; other site
592021006720	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
592021006721	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021006722	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
592021006723	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
592021006724	Cytochrome P450; Region: p450; cl12078
592021006725	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
592021006726	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021006727	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021006728	active site
592021006729	motif I; other site
592021006730	motif II; other site
592021006731	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021006732	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
592021006733	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021006734	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021006735	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021006736	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
592021006737	glycosyltransferase, MGT family; Region: MGT; TIGR01426
592021006738	active site
592021006739	TDP-binding site; other site
592021006740	acceptor substrate-binding pocket; other site
592021006741	homodimer interface [polypeptide binding]; other site
592021006742	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
592021006743	aspartate racemase; Region: asp_race; TIGR00035
592021006744	hypothetical protein; Provisional; Region: PRK13661
592021006745	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
592021006746	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
592021006747	Walker A/P-loop; other site
592021006748	ATP binding site [chemical binding]; other site
592021006749	Q-loop/lid; other site
592021006750	ABC transporter signature motif; other site
592021006751	Walker B; other site
592021006752	D-loop; other site
592021006753	H-loop/switch region; other site
592021006754	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
592021006755	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
592021006756	Walker A/P-loop; other site
592021006757	ATP binding site [chemical binding]; other site
592021006758	Q-loop/lid; other site
592021006759	ABC transporter signature motif; other site
592021006760	Walker B; other site
592021006761	D-loop; other site
592021006762	H-loop/switch region; other site
592021006763	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
592021006764	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
592021006765	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021006766	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021006767	dimer interface [polypeptide binding]; other site
592021006768	phosphorylation site [posttranslational modification]
592021006769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021006770	ATP binding site [chemical binding]; other site
592021006771	Mg2+ binding site [ion binding]; other site
592021006772	G-X-G motif; other site
592021006773	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
592021006774	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
592021006775	active site
592021006776	ATP binding site [chemical binding]; other site
592021006777	substrate binding site [chemical binding]; other site
592021006778	activation loop (A-loop); other site
592021006779	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
592021006780	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
592021006781	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
592021006782	NAD(P) binding site [chemical binding]; other site
592021006783	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
592021006784	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021006785	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021006786	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
592021006787	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
592021006788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006789	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021006790	putative substrate translocation pore; other site
592021006791	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021006792	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021006793	putative acetyltransferase; Provisional; Region: PRK03624
592021006794	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006795	Coenzyme A binding pocket [chemical binding]; other site
592021006796	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
592021006797	EDD domain protein, DegV family; Region: DegV; TIGR00762
592021006798	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
592021006799	Putative amidotransferase; Region: DUF4066; pfam13278
592021006800	conserved cys residue [active]
592021006801	Predicted transcriptional regulator [Transcription]; Region: COG2378
592021006802	HTH domain; Region: HTH_11; pfam08279
592021006803	WYL domain; Region: WYL; pfam13280
592021006804	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
592021006805	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
592021006806	conserved cys residue [active]
592021006807	Protein of unknown function (DUF975); Region: DUF975; cl10504
592021006808	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021006809	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021006810	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777
592021006811	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021006812	DNA binding residues [nucleotide binding]
592021006813	putative dimer interface [polypeptide binding]; other site
592021006814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021006815	S-adenosylmethionine binding site [chemical binding]; other site
592021006816	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021006817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006818	putative substrate translocation pore; other site
592021006819	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006820	Coenzyme A binding pocket [chemical binding]; other site
592021006821	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
592021006822	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
592021006823	active site
592021006824	catalytic site [active]
592021006825	metal binding site [ion binding]; metal-binding site
592021006826	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
592021006827	EamA-like transporter family; Region: EamA; pfam00892
592021006828	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
592021006829	EamA-like transporter family; Region: EamA; pfam00892
592021006830	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
592021006831	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
592021006832	nudix motif; other site
592021006833	probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601
592021006834	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021006835	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021006836	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
592021006837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021006838	putative substrate translocation pore; other site
592021006839	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
592021006840	nudix motif; other site
592021006841	DNA polymerase III subunit beta; Validated; Region: PRK06673
592021006842	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
592021006843	putative DNA binding surface [nucleotide binding]; other site
592021006844	dimer interface [polypeptide binding]; other site
592021006845	beta-clamp/clamp loader binding surface; other site
592021006846	beta-clamp/translesion DNA polymerase binding surface; other site
592021006847	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
592021006848	putative active site [active]
592021006849	nucleotide binding site [chemical binding]; other site
592021006850	nudix motif; other site
592021006851	putative metal binding site [ion binding]; other site
592021006852	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
592021006853	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021006854	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
592021006855	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
592021006856	translation initiation factor IF-2; Provisional; Region: PRK14845
592021006857	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
592021006858	homotrimer interaction site [polypeptide binding]; other site
592021006859	putative active site [active]
592021006860	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
592021006861	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
592021006862	YxiJ-like protein; Region: YxiJ; pfam14176
592021006863	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
592021006864	pentamer interface [polypeptide binding]; other site
592021006865	dodecaamer interface [polypeptide binding]; other site
592021006866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006867	Coenzyme A binding pocket [chemical binding]; other site
592021006868	metal-dependent hydrolase; Provisional; Region: PRK13291
592021006869	DinB superfamily; Region: DinB_2; pfam12867
592021006870	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021006871	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021006872	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
592021006873	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
592021006874	GIY-YIG motif/motif A; other site
592021006875	active site
592021006876	catalytic site [active]
592021006877	putative DNA binding site [nucleotide binding]; other site
592021006878	metal binding site [ion binding]; metal-binding site
592021006879	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
592021006880	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
592021006881	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
592021006882	active site
592021006883	ATP binding site [chemical binding]; other site
592021006884	substrate binding site [chemical binding]; other site
592021006885	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
592021006886	nudix motif; other site
592021006887	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
592021006888	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
592021006889	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
592021006890	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
592021006891	MepB protein; Region: MepB; pfam08877
592021006892	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
592021006893	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
592021006894	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021006895	motif II; other site
592021006896	DinB superfamily; Region: DinB_2; pfam12867
592021006897	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
592021006898	tyrosine decarboxylase; Region: PLN02880
592021006899	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
592021006900	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021006901	catalytic residue [active]
592021006902	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
592021006903	putative FMN binding site [chemical binding]; other site
592021006904	NADPH bind site [chemical binding]; other site
592021006905	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
592021006906	carbohydrate binding site [chemical binding]; other site
592021006907	pullulanase, type I; Region: pulA_typeI; TIGR02104
592021006908	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
592021006909	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
592021006910	Ca binding site [ion binding]; other site
592021006911	active site
592021006912	catalytic site [active]
592021006913	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
592021006914	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
592021006915	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
592021006916	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
592021006917	active site
592021006918	Zn binding site [ion binding]; other site
592021006919	Putative zinc-finger; Region: zf-HC2; pfam13490
592021006920	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
592021006921	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
592021006922	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021006923	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021006924	DNA binding residues [nucleotide binding]
592021006925	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
592021006926	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
592021006927	SecY translocase; Region: SecY; pfam00344
592021006928	hypothetical protein; Validated; Region: PRK06672
592021006929	DnaA N-terminal domain; Region: DnaA_N; pfam11638
592021006930	DnaA N-terminal domain; Region: DnaA_N; pfam11638
592021006931	DnaA N-terminal domain; Region: DnaA_N; pfam11638
592021006932	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
592021006933	EamA-like transporter family; Region: EamA; pfam00892
592021006934	EamA-like transporter family; Region: EamA; pfam00892
592021006935	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
592021006936	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021006937	DNA-binding site [nucleotide binding]; DNA binding site
592021006938	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021006939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021006940	homodimer interface [polypeptide binding]; other site
592021006941	catalytic residue [active]
592021006942	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021006943	TAP-like protein; Region: Abhydrolase_4; pfam08386
592021006944	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
592021006945	Mg binding site [ion binding]; other site
592021006946	nucleotide binding site [chemical binding]; other site
592021006947	putative protofilament interface [polypeptide binding]; other site
592021006948	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
592021006949	Predicted membrane protein [Function unknown]; Region: COG4129
592021006950	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
592021006951	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021006952	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
592021006953	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
592021006954	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
592021006955	germination protein YpeB; Region: spore_YpeB; TIGR02889
592021006956	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
592021006957	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
592021006958	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
592021006959	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
592021006960	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021006961	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021006962	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
592021006963	arylformamidase; Region: trp_arylform; TIGR03035
592021006964	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
592021006965	kynureninase; Region: kynureninase; TIGR01814
592021006966	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021006967	catalytic residue [active]
592021006968	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021006969	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021006970	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
592021006971	nudix motif; other site
592021006972	N-acetyltransferase; Region: Acetyltransf_2; cl00949
592021006973	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
592021006974	hydrophobic ligand binding site; other site
592021006975	Protein of unknown function (DUF3977); Region: DUF3977; pfam13122
592021006976	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
592021006977	GAF domain; Region: GAF; pfam01590
592021006978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021006979	Walker A motif; other site
592021006980	ATP binding site [chemical binding]; other site
592021006981	Walker B motif; other site
592021006982	arginine finger; other site
592021006983	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
592021006984	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
592021006985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021006986	Coenzyme A binding pocket [chemical binding]; other site
592021006987	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
592021006988	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
592021006989	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
592021006990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021006991	S-adenosylmethionine binding site [chemical binding]; other site
592021006992	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
592021006993	Rrf2 family protein; Region: rrf2_super; TIGR00738
592021006994	Transcriptional regulator; Region: Rrf2; pfam02082
592021006995	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
592021006996	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021006997	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021006998	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
592021006999	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
592021007000	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
592021007001	E3 interaction surface; other site
592021007002	lipoyl attachment site [posttranslational modification]; other site
592021007003	e3 binding domain; Region: E3_binding; pfam02817
592021007004	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
592021007005	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
592021007006	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
592021007007	alpha subunit interface [polypeptide binding]; other site
592021007008	TPP binding site [chemical binding]; other site
592021007009	heterodimer interface [polypeptide binding]; other site
592021007010	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
592021007011	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
592021007012	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
592021007013	tetramer interface [polypeptide binding]; other site
592021007014	TPP-binding site [chemical binding]; other site
592021007015	heterodimer interface [polypeptide binding]; other site
592021007016	phosphorylation loop region [posttranslational modification]
592021007017	DinB superfamily; Region: DinB_2; pfam12867
592021007018	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
592021007019	short chain dehydrogenase; Provisional; Region: PRK06914
592021007020	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
592021007021	NADP binding site [chemical binding]; other site
592021007022	active site
592021007023	steroid binding site; other site
592021007024	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
592021007025	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
592021007026	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
592021007027	nudix motif; other site
592021007028	Protein phosphatase 2C; Region: PP2C_2; pfam13672
592021007029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021007030	dimer interface [polypeptide binding]; other site
592021007031	conserved gate region; other site
592021007032	putative PBP binding loops; other site
592021007033	ABC-ATPase subunit interface; other site
592021007034	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
592021007035	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
592021007036	Walker A/P-loop; other site
592021007037	ATP binding site [chemical binding]; other site
592021007038	Q-loop/lid; other site
592021007039	ABC transporter signature motif; other site
592021007040	Walker B; other site
592021007041	D-loop; other site
592021007042	H-loop/switch region; other site
592021007043	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
592021007044	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
592021007045	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
592021007046	Clp protease; Region: CLP_protease; pfam00574
592021007047	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
592021007048	oligomer interface [polypeptide binding]; other site
592021007049	active site residues [active]
592021007050	RNA polymerase factor sigma-70; Validated; Region: PRK06704
592021007051	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021007052	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
592021007053	DNA binding residues [nucleotide binding]
592021007054	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
592021007055	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
592021007056	catalytic loop [active]
592021007057	iron binding site [ion binding]; other site
592021007058	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
592021007059	tetramer (dimer of dimers) interface [polypeptide binding]; other site
592021007060	active site
592021007061	dimer interface [polypeptide binding]; other site
592021007062	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007063	Coenzyme A binding pocket [chemical binding]; other site
592021007064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
592021007065	Chitin binding domain; Region: Chitin_bind_3; pfam03067
592021007066	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
592021007067	Interdomain contacts; other site
592021007068	Cytokine receptor motif; other site
592021007069	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
592021007070	Interdomain contacts; other site
592021007071	Cytokine receptor motif; other site
592021007072	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
592021007073	topology modulation protein; Reviewed; Region: PRK08118
592021007074	AAA domain; Region: AAA_17; pfam13207
592021007075	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
592021007076	Protein of unknown function (DUF419); Region: DUF419; cl15265
592021007077	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
592021007078	Protein of unknown function; Region: DUF3658; pfam12395
592021007079	Protein of unknown function (DUF419); Region: DUF419; pfam04237
592021007080	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007081	Coenzyme A binding pocket [chemical binding]; other site
592021007082	S-layer homology domain; Region: SLH; pfam00395
592021007083	S-layer homology domain; Region: SLH; pfam00395
592021007084	S-layer homology domain; Region: SLH; pfam00395
592021007085	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
592021007086	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021007087	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
592021007088	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
592021007089	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
592021007090	active site
592021007091	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
592021007092	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007093	Coenzyme A binding pocket [chemical binding]; other site
592021007094	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
592021007095	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021007096	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
592021007097	Protein of unknown function (DUF952); Region: DUF952; pfam06108
592021007098	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
592021007099	Part of AAA domain; Region: AAA_19; pfam13245
592021007100	Family description; Region: UvrD_C_2; pfam13538
592021007101	CAAX protease self-immunity; Region: Abi; pfam02517
592021007102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021007103	S-adenosylmethionine binding site [chemical binding]; other site
592021007104	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
592021007105	putative active site pocket [active]
592021007106	dimerization interface [polypeptide binding]; other site
592021007107	putative catalytic residue [active]
592021007108	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
592021007109	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021007110	ATP binding site [chemical binding]; other site
592021007111	putative Mg++ binding site [ion binding]; other site
592021007112	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021007113	nucleotide binding region [chemical binding]; other site
592021007114	ATP-binding site [chemical binding]; other site
592021007115	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
592021007116	HRDC domain; Region: HRDC; pfam00570
592021007117	Protein of unknown function (DUF4017); Region: DUF4017; pfam13209
592021007118	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
592021007119	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
592021007120	active site
592021007121	Zn binding site [ion binding]; other site
592021007122	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
592021007123	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
592021007124	DHHA2 domain; Region: DHHA2; pfam02833
592021007125	Chitin binding domain; Region: Chitin_bind_3; pfam03067
592021007126	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021007127	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007128	Coenzyme A binding pocket [chemical binding]; other site
592021007129	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
592021007130	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
592021007131	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
592021007132	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
592021007133	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
592021007134	NAD(P) binding site [chemical binding]; other site
592021007135	catalytic residues [active]
592021007136	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
592021007137	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
592021007138	inhibitor site; inhibition site
592021007139	active site
592021007140	dimer interface [polypeptide binding]; other site
592021007141	catalytic residue [active]
592021007142	Proline racemase; Region: Pro_racemase; pfam05544
592021007143	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
592021007144	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
592021007145	Proline racemase; Region: Pro_racemase; pfam05544
592021007146	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
592021007147	hydroxyglutarate oxidase; Provisional; Region: PRK11728
592021007148	PAS domain; Region: PAS; smart00091
592021007149	PAS domain; Region: PAS_9; pfam13426
592021007150	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
592021007151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021007152	Walker A motif; other site
592021007153	ATP binding site [chemical binding]; other site
592021007154	Walker B motif; other site
592021007155	arginine finger; other site
592021007156	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
592021007157	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
592021007158	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
592021007159	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
592021007160	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
592021007161	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
592021007162	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
592021007163	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
592021007164	DltD N-terminal region; Region: DltD_N; pfam04915
592021007165	DltD central region; Region: DltD_M; pfam04918
592021007166	DltD C-terminal region; Region: DltD_C; pfam04914
592021007167	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021007168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007169	Coenzyme A binding pocket [chemical binding]; other site
592021007170	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021007171	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021007172	peptide binding site [polypeptide binding]; other site
592021007173	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
592021007174	NlpC/P60 family; Region: NLPC_P60; pfam00877
592021007175	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
592021007176	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
592021007177	active site
592021007178	Septum formation initiator; Region: DivIC; pfam04977
592021007179	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
592021007180	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
592021007181	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
592021007182	active site
592021007183	catalytic motif [active]
592021007184	Zn binding site [ion binding]; other site
592021007185	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021007186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021007187	S-adenosylmethionine binding site [chemical binding]; other site
592021007188	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
592021007189	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
592021007190	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021007191	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021007192	dimerization interface [polypeptide binding]; other site
592021007193	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021007194	dimer interface [polypeptide binding]; other site
592021007195	phosphorylation site [posttranslational modification]
592021007196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021007197	ATP binding site [chemical binding]; other site
592021007198	Mg2+ binding site [ion binding]; other site
592021007199	G-X-G motif; other site
592021007200	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
592021007201	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
592021007202	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
592021007203	Short C-terminal domain; Region: SHOCT; pfam09851
592021007204	EDD domain protein, DegV family; Region: DegV; TIGR00762
592021007205	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
592021007206	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021007207	Coenzyme A binding pocket [chemical binding]; other site
592021007208	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
592021007209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007210	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021007211	putative substrate translocation pore; other site
592021007212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007213	putative substrate translocation pore; other site
592021007214	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
592021007215	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
592021007216	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
592021007217	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
592021007218	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
592021007219	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
592021007220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007221	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021007222	putative substrate translocation pore; other site
592021007223	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
592021007224	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
592021007225	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
592021007226	active site
592021007227	Protein of unknown function (DUF3970); Region: DUF3970; pfam13113
592021007228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007229	putative substrate translocation pore; other site
592021007230	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021007231	aspartate aminotransferase; Provisional; Region: PRK07681
592021007232	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021007233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021007234	homodimer interface [polypeptide binding]; other site
592021007235	catalytic residue [active]
592021007236	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
592021007237	pantothenate kinase; Provisional; Region: PRK13317
592021007238	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
592021007239	CAAX protease self-immunity; Region: Abi; pfam02517
592021007240	Protein of unknown function (DUF4052); Region: DUF4052; pfam13261
592021007241	Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413
592021007242	Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413
592021007243	Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413
592021007244	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
592021007245	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
592021007246	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
592021007247	Domain of unknown function DUF20; Region: UPF0118; pfam01594
592021007248	HNH endonuclease; Region: HNH_5; pfam14279
592021007249	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
592021007250	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
592021007251	active site
592021007252	dimer interface [polypeptide binding]; other site
592021007253	non-prolyl cis peptide bond; other site
592021007254	insertion regions; other site
592021007255	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
592021007256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021007257	dimer interface [polypeptide binding]; other site
592021007258	conserved gate region; other site
592021007259	putative PBP binding loops; other site
592021007260	ABC-ATPase subunit interface; other site
592021007261	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
592021007262	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
592021007263	substrate binding pocket [chemical binding]; other site
592021007264	membrane-bound complex binding site; other site
592021007265	hinge residues; other site
592021007266	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
592021007267	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
592021007268	Walker A/P-loop; other site
592021007269	ATP binding site [chemical binding]; other site
592021007270	Q-loop/lid; other site
592021007271	ABC transporter signature motif; other site
592021007272	Walker B; other site
592021007273	D-loop; other site
592021007274	H-loop/switch region; other site
592021007275	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021007276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021007277	Protein of unknown function (DUF402); Region: DUF402; pfam04167
592021007278	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
592021007279	nudix motif; other site
592021007280	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
592021007281	binding surface
592021007282	TPR motif; other site
592021007283	hypothetical protein; Provisional; Region: PRK09620
592021007284	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
592021007285	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
592021007286	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
592021007287	Coenzyme A binding pocket [chemical binding]; other site
592021007288	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
592021007289	DinB superfamily; Region: DinB_2; pfam12867
592021007290	Protein of unknown function (DUF664); Region: DUF664; pfam04978
592021007291	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
592021007292	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007293	Coenzyme A binding pocket [chemical binding]; other site
592021007294	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021007295	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021007296	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
592021007297	active site
592021007298	NTP binding site [chemical binding]; other site
592021007299	metal binding triad [ion binding]; metal-binding site
592021007300	antibiotic binding site [chemical binding]; other site
592021007301	A new structural DNA glycosylase; Region: AlkD_like; cd06561
592021007302	active site
592021007303	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
592021007304	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
592021007305	NodB motif; other site
592021007306	active site
592021007307	catalytic site [active]
592021007308	Zn binding site [ion binding]; other site
592021007309	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
592021007310	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
592021007311	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
592021007312	Sulfatase; Region: Sulfatase; pfam00884
592021007313	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
592021007314	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021007315	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021007316	ABC transporter; Region: ABC_tran_2; pfam12848
592021007317	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021007318	hypothetical protein; Provisional; Region: PRK06761
592021007319	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021007320	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021007321	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
592021007322	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007323	Coenzyme A binding pocket [chemical binding]; other site
592021007324	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
592021007325	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
592021007326	hinge; other site
592021007327	active site
592021007328	prephenate dehydrogenase; Validated; Region: PRK06545
592021007329	prephenate dehydrogenase; Validated; Region: PRK08507
592021007330	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
592021007331	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
592021007332	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021007333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021007334	homodimer interface [polypeptide binding]; other site
592021007335	catalytic residue [active]
592021007336	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
592021007337	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
592021007338	Tetramer interface [polypeptide binding]; other site
592021007339	active site
592021007340	FMN-binding site [chemical binding]; other site
592021007341	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
592021007342	Chorismate mutase type II; Region: CM_2; cl00693
592021007343	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
592021007344	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
592021007345	Isochorismatase family; Region: Isochorismatase; pfam00857
592021007346	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
592021007347	catalytic triad [active]
592021007348	conserved cis-peptide bond; other site
592021007349	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021007350	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007351	Coenzyme A binding pocket [chemical binding]; other site
592021007352	YfzA-like protein; Region: YfzA; pfam14118
592021007353	hypothetical protein; Provisional; Region: PRK06762
592021007354	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021007355	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021007356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
592021007357	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
592021007358	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021007359	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021007360	DNA binding residues [nucleotide binding]
592021007361	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
592021007362	malate:quinone oxidoreductase; Validated; Region: PRK05257
592021007363	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
592021007364	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
592021007365	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
592021007366	ligand binding site [chemical binding]; other site
592021007367	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
592021007368	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
592021007369	TM-ABC transporter signature motif; other site
592021007370	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
592021007371	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
592021007372	TM-ABC transporter signature motif; other site
592021007373	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
592021007374	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
592021007375	Cupin domain; Region: Cupin_2; pfam07883
592021007376	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
592021007377	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
592021007378	putative active site; other site
592021007379	catalytic residue [active]
592021007380	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021007381	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021007382	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
592021007383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007384	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021007385	putative substrate translocation pore; other site
592021007386	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021007387	putative DNA binding site [nucleotide binding]; other site
592021007388	putative Zn2+ binding site [ion binding]; other site
592021007389	DinB superfamily; Region: DinB_2; pfam12867
592021007390	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
592021007391	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
592021007392	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
592021007393	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
592021007394	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
592021007395	putative catalytic cysteine [active]
592021007396	gamma-glutamyl kinase; Provisional; Region: PRK05429
592021007397	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
592021007398	nucleotide binding site [chemical binding]; other site
592021007399	homotetrameric interface [polypeptide binding]; other site
592021007400	putative phosphate binding site [ion binding]; other site
592021007401	putative allosteric binding site; other site
592021007402	PUA domain; Region: PUA; pfam01472
592021007403	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491
592021007404	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
592021007405	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
592021007406	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
592021007407	putative metal binding site [ion binding]; other site
592021007408	putative dimer interface [polypeptide binding]; other site
592021007409	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
592021007410	Transcriptional regulator [Transcription]; Region: IclR; COG1414
592021007411	Bacterial transcriptional regulator; Region: IclR; pfam01614
592021007412	S-methylmethionine transporter; Provisional; Region: PRK11387
592021007413	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
592021007414	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
592021007415	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
592021007416	dimer interface [polypeptide binding]; other site
592021007417	active site
592021007418	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
592021007419	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021007420	salt bridge; other site
592021007421	non-specific DNA binding site [nucleotide binding]; other site
592021007422	sequence-specific DNA binding site [nucleotide binding]; other site
592021007423	Protein of unknown function (DUF3887); Region: DUF3887; pfam13026
592021007424	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
592021007425	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
592021007426	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
592021007427	LytTr DNA-binding domain; Region: LytTR; pfam04397
592021007428	uridine kinase; Provisional; Region: PRK07667
592021007429	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021007430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007431	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021007432	Coenzyme A binding pocket [chemical binding]; other site
592021007433	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021007434	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
592021007435	active site
592021007436	metal binding site [ion binding]; metal-binding site
592021007437	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
592021007438	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021007439	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
592021007440	MoxR-like ATPases [General function prediction only]; Region: COG0714
592021007441	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021007442	Walker A motif; other site
592021007443	ATP binding site [chemical binding]; other site
592021007444	Walker B motif; other site
592021007445	arginine finger; other site
592021007446	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
592021007447	Protein of unknown function DUF58; Region: DUF58; pfam01882
592021007448	proline/glycine betaine transporter; Provisional; Region: PRK10642
592021007449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007450	putative substrate translocation pore; other site
592021007451	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021007452	active site
592021007453	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021007454	active site
592021007455	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021007456	active site
592021007457	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
592021007458	Ligand binding site; other site
592021007459	Putative Catalytic site; other site
592021007460	DXD motif; other site
592021007461	acetylornithine aminotransferase; Provisional; Region: PRK02627
592021007462	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021007463	inhibitor-cofactor binding pocket; inhibition site
592021007464	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021007465	catalytic residue [active]
592021007466	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
592021007467	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
592021007468	tetramer interface [polypeptide binding]; other site
592021007469	heme binding pocket [chemical binding]; other site
592021007470	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
592021007471	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
592021007472	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
592021007473	active site
592021007474	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
592021007475	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021007476	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021007477	Protein of unknown function (DUF3902); Region: DUF3902; pfam13042
592021007478	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
592021007479	Protein of unknown function DUF58; Region: DUF58; pfam01882
592021007480	MoxR-like ATPases [General function prediction only]; Region: COG0714
592021007481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021007482	Walker A motif; other site
592021007483	ATP binding site [chemical binding]; other site
592021007484	Walker B motif; other site
592021007485	arginine finger; other site
592021007486	Uncharacterized conserved protein [Function unknown]; Region: COG1359
592021007487	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
592021007488	dimer interface [polypeptide binding]; other site
592021007489	FMN binding site [chemical binding]; other site
592021007490	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021007491	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021007492	putative DNA binding site [nucleotide binding]; other site
592021007493	putative Zn2+ binding site [ion binding]; other site
592021007494	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
592021007495	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
592021007496	G1 box; other site
592021007497	putative GEF interaction site [polypeptide binding]; other site
592021007498	GTP/Mg2+ binding site [chemical binding]; other site
592021007499	Switch I region; other site
592021007500	G2 box; other site
592021007501	G3 box; other site
592021007502	Switch II region; other site
592021007503	G4 box; other site
592021007504	G5 box; other site
592021007505	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
592021007506	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
592021007507	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
592021007508	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
592021007509	nudix motif; other site
592021007510	YfzA-like protein; Region: YfzA; pfam14118
592021007511	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
592021007512	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021007513	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021007514	Walker A/P-loop; other site
592021007515	ATP binding site [chemical binding]; other site
592021007516	Q-loop/lid; other site
592021007517	ABC transporter signature motif; other site
592021007518	Walker B; other site
592021007519	D-loop; other site
592021007520	H-loop/switch region; other site
592021007521	Predicted transcriptional regulators [Transcription]; Region: COG1725
592021007522	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021007523	DNA-binding site [nucleotide binding]; DNA binding site
592021007524	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
592021007525	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
592021007526	putative NAD(P) binding site [chemical binding]; other site
592021007527	active site
592021007528	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021007529	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021007530	Walker A/P-loop; other site
592021007531	ATP binding site [chemical binding]; other site
592021007532	Q-loop/lid; other site
592021007533	ABC transporter signature motif; other site
592021007534	Walker B; other site
592021007535	D-loop; other site
592021007536	H-loop/switch region; other site
592021007537	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
592021007538	FtsX-like permease family; Region: FtsX; pfam02687
592021007539	FtsX-like permease family; Region: FtsX; pfam02687
592021007540	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021007541	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021007542	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
592021007543	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021007544	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
592021007545	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021007546	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007547	Coenzyme A binding pocket [chemical binding]; other site
592021007548	Domain of unknown function (DUF3980); Region: DUF3980; pfam13140
592021007549	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
592021007550	nudix motif; other site
592021007551	EamA-like transporter family; Region: EamA; pfam00892
592021007552	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
592021007553	EamA-like transporter family; Region: EamA; pfam00892
592021007554	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
592021007555	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021007556	DNA-binding site [nucleotide binding]; DNA binding site
592021007557	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021007558	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021007559	homodimer interface [polypeptide binding]; other site
592021007560	catalytic residue [active]
592021007561	hypothetical protein; Validated; Region: PRK00124
592021007562	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
592021007563	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021007564	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
592021007565	phosphorylation site [posttranslational modification]
592021007566	dimer interface [polypeptide binding]; other site
592021007567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021007568	ATP binding site [chemical binding]; other site
592021007569	Mg2+ binding site [ion binding]; other site
592021007570	G-X-G motif; other site
592021007571	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021007572	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021007573	active site
592021007574	phosphorylation site [posttranslational modification]
592021007575	intermolecular recognition site; other site
592021007576	dimerization interface [polypeptide binding]; other site
592021007577	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021007578	DNA binding site [nucleotide binding]
592021007579	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021007580	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
592021007581	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
592021007582	uridine kinase; Validated; Region: PRK06696
592021007583	active site
592021007584	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
592021007585	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
592021007586	active site
592021007587	metal binding site [ion binding]; metal-binding site
592021007588	Phosphotransferase enzyme family; Region: APH; pfam01636
592021007589	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
592021007590	active site
592021007591	substrate binding site [chemical binding]; other site
592021007592	ATP binding site [chemical binding]; other site
592021007593	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
592021007594	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
592021007595	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021007596	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007597	Coenzyme A binding pocket [chemical binding]; other site
592021007598	lysine transporter; Provisional; Region: PRK10836
592021007599	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
592021007600	Protein of unknown function (DUF2716); Region: DUF2716; pfam10898
592021007601	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021007602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021007603	S-adenosylmethionine binding site [chemical binding]; other site
592021007604	Cephalosporin hydroxylase; Region: CmcI; pfam04989
592021007605	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
592021007606	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
592021007607	Catalytic site [active]
592021007608	NAD-dependent deacetylase; Provisional; Region: PRK00481
592021007609	SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413
592021007610	NAD+ binding site [chemical binding]; other site
592021007611	substrate binding site [chemical binding]; other site
592021007612	Zn binding site [ion binding]; other site
592021007613	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
592021007614	putative substrate binding pocket [chemical binding]; other site
592021007615	AC domain interface; other site
592021007616	catalytic triad [active]
592021007617	AB domain interface; other site
592021007618	interchain disulfide; other site
592021007619	Predicted membrane protein [Function unknown]; Region: COG3817
592021007620	Protein of unknown function (DUF979); Region: DUF979; pfam06166
592021007621	Protein of unknown function (DUF969); Region: DUF969; pfam06149
592021007622	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
592021007623	putative active site [active]
592021007624	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
592021007625	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
592021007626	Transcriptional regulator [Transcription]; Region: IclR; COG1414
592021007627	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
592021007628	Bacterial transcriptional regulator; Region: IclR; pfam01614
592021007629	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
592021007630	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
592021007631	Catalytic site [active]
592021007632	CutC family; Region: CutC; cl01218
592021007633	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
592021007634	stage II sporulation protein P; Region: spore_II_P; TIGR02867
592021007635	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021007636	dimerization interface [polypeptide binding]; other site
592021007637	putative DNA binding site [nucleotide binding]; other site
592021007638	putative Zn2+ binding site [ion binding]; other site
592021007639	DinB superfamily; Region: DinB_2; pfam12867
592021007640	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
592021007641	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
592021007642	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
592021007643	Uncharacterized conserved protein [Function unknown]; Region: COG1434
592021007644	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
592021007645	putative active site [active]
592021007646	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021007647	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021007648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
592021007649	Nucleoside recognition; Region: Gate; pfam07670
592021007650	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
592021007651	Phosphotransferase enzyme family; Region: APH; pfam01636
592021007652	putative active site [active]
592021007653	putative substrate binding site [chemical binding]; other site
592021007654	ATP binding site [chemical binding]; other site
592021007655	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007656	Coenzyme A binding pocket [chemical binding]; other site
592021007657	Uncharacterized conserved protein [Function unknown]; Region: COG1633
592021007658	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
592021007659	dinuclear metal binding motif [ion binding]; other site
592021007660	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
592021007661	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
592021007662	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021007663	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021007664	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
592021007665	phosphoenolpyruvate synthase; Validated; Region: PRK06241
592021007666	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
592021007667	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
592021007668	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021007669	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
592021007670	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
592021007671	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
592021007672	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
592021007673	LysE type translocator; Region: LysE; pfam01810
592021007674	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
592021007675	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
592021007676	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
592021007677	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
592021007678	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
592021007679	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
592021007680	NAD binding site [chemical binding]; other site
592021007681	catalytic Zn binding site [ion binding]; other site
592021007682	structural Zn binding site [ion binding]; other site
592021007683	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
592021007684	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
592021007685	dimanganese center [ion binding]; other site
592021007686	aspartate ammonia-lyase; Provisional; Region: PRK14515
592021007687	Aspartase; Region: Aspartase; cd01357
592021007688	active sites [active]
592021007689	tetramer interface [polypeptide binding]; other site
592021007690	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
592021007691	active site
592021007692	homodimer interface [polypeptide binding]; other site
592021007693	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021007694	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021007695	non-specific DNA binding site [nucleotide binding]; other site
592021007696	salt bridge; other site
592021007697	sequence-specific DNA binding site [nucleotide binding]; other site
592021007698	Integrase core domain; Region: rve_3; cl15866
592021007699	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
592021007700	GIY-YIG motif/motif A; other site
592021007701	active site
592021007702	catalytic site [active]
592021007703	putative DNA binding site [nucleotide binding]; other site
592021007704	metal binding site [ion binding]; metal-binding site
592021007705	amino acid transporter; Region: 2A0306; TIGR00909
592021007706	Spore germination protein; Region: Spore_permease; cl17796
592021007707	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
592021007708	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
592021007709	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491
592021007710	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
592021007711	DoxX-like family; Region: DoxX_2; pfam13564
592021007712	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
592021007713	Malic enzyme, N-terminal domain; Region: malic; pfam00390
592021007714	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
592021007715	putative NAD(P) binding site [chemical binding]; other site
592021007716	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
592021007717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021007718	Response regulator receiver domain; Region: Response_reg; pfam00072
592021007719	active site
592021007720	phosphorylation site [posttranslational modification]
592021007721	intermolecular recognition site; other site
592021007722	dimerization interface [polypeptide binding]; other site
592021007723	YcbB domain; Region: YcbB; pfam08664
592021007724	glutaminase; Reviewed; Region: PRK12357
592021007725	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
592021007726	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
592021007727	transmembrane helices; other site
592021007728	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
592021007729	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
592021007730	active site
592021007731	active site
592021007732	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
592021007733	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
592021007734	putative active site [active]
592021007735	putative metal binding site [ion binding]; other site
592021007736	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
592021007737	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
592021007738	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
592021007739	tetramer interface [polypeptide binding]; other site
592021007740	heme binding pocket [chemical binding]; other site
592021007741	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021007742	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
592021007743	TAP-like protein; Region: Abhydrolase_4; pfam08386
592021007744	Isochorismatase family; Region: Isochorismatase; pfam00857
592021007745	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
592021007746	catalytic triad [active]
592021007747	dimer interface [polypeptide binding]; other site
592021007748	conserved cis-peptide bond; other site
592021007749	Isochorismatase family; Region: Isochorismatase; pfam00857
592021007750	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
592021007751	catalytic triad [active]
592021007752	dimer interface [polypeptide binding]; other site
592021007753	conserved cis-peptide bond; other site
592021007754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
592021007755	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021007756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021007757	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021007758	dimerization interface [polypeptide binding]; other site
592021007759	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
592021007760	Mg binding site [ion binding]; other site
592021007761	nucleotide binding site [chemical binding]; other site
592021007762	putative protofilament interface [polypeptide binding]; other site
592021007763	Heat induced stress protein YflT; Region: YflT; pfam11181
592021007764	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
592021007765	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
592021007766	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
592021007767	TspO/MBR family; Region: TspO_MBR; pfam03073
592021007768	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
592021007769	DNA photolyase; Region: DNA_photolyase; pfam00875
592021007770	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
592021007771	zinc binding site [ion binding]; other site
592021007772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
592021007773	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
592021007774	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
592021007775	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
592021007776	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
592021007777	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
592021007778	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021007779	Coenzyme A binding pocket [chemical binding]; other site
592021007780	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
592021007781	UbiA prenyltransferase family; Region: UbiA; pfam01040
592021007782	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021007783	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
592021007784	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
592021007785	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
592021007786	metal binding site [ion binding]; metal-binding site
592021007787	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
592021007788	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021007789	ABC-ATPase subunit  interface; other site
592021007790	dimer interface [polypeptide binding]; other site
592021007791	putative PBP binding regions; other site
592021007792	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
592021007793	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
592021007794	DJ-1 family protein; Region: not_thiJ; TIGR01383
592021007795	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
592021007796	conserved cys residue [active]
592021007797	Phosphotransferase enzyme family; Region: APH; pfam01636
592021007798	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
592021007799	active site
592021007800	ATP binding site [chemical binding]; other site
592021007801	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
592021007802	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
592021007803	Low molecular weight phosphatase family; Region: LMWPc; cd00115
592021007804	active site
592021007805	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
592021007806	arsenical-resistance protein; Region: acr3; TIGR00832
592021007807	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021007808	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
592021007809	putative metal binding site [ion binding]; other site
592021007810	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021007811	dimerization interface [polypeptide binding]; other site
592021007812	putative DNA binding site [nucleotide binding]; other site
592021007813	putative Zn2+ binding site [ion binding]; other site
592021007814	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
592021007815	DnaJ domain; Region: DnaJ; pfam00226
592021007816	HSP70 interaction site [polypeptide binding]; other site
592021007817	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021007818	binding surface
592021007819	TPR motif; other site
592021007820	TPR repeat; Region: TPR_11; pfam13414
592021007821	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
592021007822	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
592021007823	nucleotide binding site [chemical binding]; other site
592021007824	putative NEF/HSP70 interaction site [polypeptide binding]; other site
592021007825	SBD interface [polypeptide binding]; other site
592021007826	short chain dehydrogenase; Provisional; Region: PRK12746
592021007827	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
592021007828	NADP binding site [chemical binding]; other site
592021007829	homodimer interface [polypeptide binding]; other site
592021007830	active site
592021007831	substrate binding site [chemical binding]; other site
592021007832	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
592021007833	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021007834	putative DNA binding site [nucleotide binding]; other site
592021007835	putative Zn2+ binding site [ion binding]; other site
592021007836	AsnC family; Region: AsnC_trans_reg; pfam01037
592021007837	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
592021007838	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
592021007839	metal binding site [ion binding]; metal-binding site
592021007840	AAA domain; Region: AAA_11; pfam13086
592021007841	Part of AAA domain; Region: AAA_19; pfam13245
592021007842	Erp protein C-terminus; Region: Erp_C; pfam06780
592021007843	AAA domain; Region: AAA_30; pfam13604
592021007844	AAA domain; Region: AAA_12; pfam13087
592021007845	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
592021007846	putative active site [active]
592021007847	catalytic site [active]
592021007848	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021007849	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
592021007850	active site
592021007851	metal binding site [ion binding]; metal-binding site
592021007852	HEAT repeats; Region: HEAT_2; pfam13646
592021007853	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
592021007854	putative transporter; Provisional; Region: PRK11021
592021007855	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021007856	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021007857	hypothetical protein; Provisional; Region: PRK06770
592021007858	putative monooxygenase; Provisional; Region: PRK11118
592021007859	DoxX-like family; Region: DoxX_2; pfam13564
592021007860	Transcriptional regulators [Transcription]; Region: MarR; COG1846
592021007861	MarR family; Region: MarR_2; pfam12802
592021007862	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
592021007863	Cytochrome P450; Region: p450; pfam00067
592021007864	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
592021007865	Flavodoxin; Region: Flavodoxin_1; pfam00258
592021007866	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
592021007867	FAD binding pocket [chemical binding]; other site
592021007868	FAD binding motif [chemical binding]; other site
592021007869	catalytic residues [active]
592021007870	NAD binding pocket [chemical binding]; other site
592021007871	phosphate binding motif [ion binding]; other site
592021007872	beta-alpha-beta structure motif; other site
592021007873	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
592021007874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007875	putative substrate translocation pore; other site
592021007876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007877	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
592021007878	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021007879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021007880	active site
592021007881	phosphorylation site [posttranslational modification]
592021007882	intermolecular recognition site; other site
592021007883	dimerization interface [polypeptide binding]; other site
592021007884	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021007885	DNA binding site [nucleotide binding]
592021007886	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021007887	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021007888	dimerization interface [polypeptide binding]; other site
592021007889	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021007890	dimer interface [polypeptide binding]; other site
592021007891	phosphorylation site [posttranslational modification]
592021007892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021007893	ATP binding site [chemical binding]; other site
592021007894	G-X-G motif; other site
592021007895	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
592021007896	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
592021007897	D-cysteine desulfhydrase; Validated; Region: PRK03910
592021007898	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
592021007899	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021007900	catalytic residue [active]
592021007901	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021007902	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021007903	salt bridge; other site
592021007904	non-specific DNA binding site [nucleotide binding]; other site
592021007905	sequence-specific DNA binding site [nucleotide binding]; other site
592021007906	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
592021007907	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
592021007908	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
592021007909	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
592021007910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
592021007911	NAD(P) binding site [chemical binding]; other site
592021007912	active site
592021007913	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
592021007914	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
592021007915	dimer interface [polypeptide binding]; other site
592021007916	active site
592021007917	CoA binding pocket [chemical binding]; other site
592021007918	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
592021007919	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
592021007920	AAA domain; Region: AAA_33; pfam13671
592021007921	AAA domain; Region: AAA_17; pfam13207
592021007922	Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702
592021007923	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
592021007924	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021007925	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021007926	Walker A/P-loop; other site
592021007927	ATP binding site [chemical binding]; other site
592021007928	Q-loop/lid; other site
592021007929	ABC transporter signature motif; other site
592021007930	Walker B; other site
592021007931	D-loop; other site
592021007932	H-loop/switch region; other site
592021007933	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
592021007934	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
592021007935	FtsX-like permease family; Region: FtsX; pfam02687
592021007936	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021007937	dimerization interface [polypeptide binding]; other site
592021007938	putative DNA binding site [nucleotide binding]; other site
592021007939	Predicted transcriptional regulator [Transcription]; Region: COG2345
592021007940	putative Zn2+ binding site [ion binding]; other site
592021007941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007942	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021007943	putative substrate translocation pore; other site
592021007944	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
592021007945	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021007946	dimerization interface [polypeptide binding]; other site
592021007947	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021007948	dimer interface [polypeptide binding]; other site
592021007949	phosphorylation site [posttranslational modification]
592021007950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021007951	ATP binding site [chemical binding]; other site
592021007952	Mg2+ binding site [ion binding]; other site
592021007953	G-X-G motif; other site
592021007954	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021007955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021007956	active site
592021007957	phosphorylation site [posttranslational modification]
592021007958	intermolecular recognition site; other site
592021007959	dimerization interface [polypeptide binding]; other site
592021007960	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021007961	DNA binding site [nucleotide binding]
592021007962	Predicted membrane protein [Function unknown]; Region: COG2364
592021007963	Transcriptional regulators [Transcription]; Region: MarR; COG1846
592021007964	MarR family; Region: MarR; pfam01047
592021007965	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
592021007966	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021007967	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021007968	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021007969	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007970	D-galactonate transporter; Region: 2A0114; TIGR00893
592021007971	putative substrate translocation pore; other site
592021007972	Uncharacterized conserved protein [Function unknown]; Region: COG1556
592021007973	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
592021007974	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
592021007975	4Fe-4S binding domain; Region: Fer4; pfam00037
592021007976	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
592021007977	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
592021007978	Cysteine-rich domain; Region: CCG; pfam02754
592021007979	Cysteine-rich domain; Region: CCG; pfam02754
592021007980	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021007981	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021007982	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021007983	dimerization interface [polypeptide binding]; other site
592021007984	F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763
592021007985	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
592021007986	putative dimer interface [polypeptide binding]; other site
592021007987	catalytic triad [active]
592021007988	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
592021007989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021007990	putative substrate translocation pore; other site
592021007991	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
592021007992	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
592021007993	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
592021007994	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021007995	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021007996	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021007997	DNA binding site [nucleotide binding]
592021007998	domain linker motif; other site
592021007999	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
592021008000	putative dimerization interface [polypeptide binding]; other site
592021008001	putative ligand binding site [chemical binding]; other site
592021008002	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
592021008003	TPR motif; other site
592021008004	Tetratricopeptide repeat; Region: TPR_12; pfam13424
592021008005	binding surface
592021008006	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021008007	TPR motif; other site
592021008008	binding surface
592021008009	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
592021008010	PKC phosphorylation site [posttranslational modification]; other site
592021008011	DNA polymerase IV; Reviewed; Region: PRK03103
592021008012	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
592021008013	active site
592021008014	DNA binding site [nucleotide binding]
592021008015	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
592021008016	YolD-like protein; Region: YolD; pfam08863
592021008017	Tar ligand binding domain homologue; Region: TarH; pfam02203
592021008018	Cache domain; Region: Cache_1; pfam02743
592021008019	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021008020	dimerization interface [polypeptide binding]; other site
592021008021	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021008022	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021008023	dimer interface [polypeptide binding]; other site
592021008024	putative CheW interface [polypeptide binding]; other site
592021008025	CAAX protease self-immunity; Region: Abi; pfam02517
592021008026	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021008027	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021008028	Coenzyme A binding pocket [chemical binding]; other site
592021008029	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
592021008030	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
592021008031	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
592021008032	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
592021008033	FOG: PKD repeat [General function prediction only]; Region: COG3291
592021008034	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
592021008035	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
592021008036	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
592021008037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021008038	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021008039	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021008040	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021008041	dimerization interface [polypeptide binding]; other site
592021008042	putative DNA binding site [nucleotide binding]; other site
592021008043	putative Zn2+ binding site [ion binding]; other site
592021008044	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
592021008045	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
592021008046	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
592021008047	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
592021008048	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
592021008049	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
592021008050	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021008051	inhibitor-cofactor binding pocket; inhibition site
592021008052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021008053	catalytic residue [active]
592021008054	Acylphosphatase; Region: Acylphosphatase; pfam00708
592021008055	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
592021008056	HypF finger; Region: zf-HYPF; pfam07503
592021008057	HypF finger; Region: zf-HYPF; pfam07503
592021008058	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
592021008059	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
592021008060	dimerization interface [polypeptide binding]; other site
592021008061	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
592021008062	ATP binding site [chemical binding]; other site
592021008063	Isochorismatase family; Region: Isochorismatase; pfam00857
592021008064	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
592021008065	catalytic triad [active]
592021008066	conserved cis-peptide bond; other site
592021008067	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
592021008068	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021008069	putative DNA binding site [nucleotide binding]; other site
592021008070	putative Zn2+ binding site [ion binding]; other site
592021008071	AsnC family; Region: AsnC_trans_reg; pfam01037
592021008072	putative transporter; Provisional; Region: PRK11021
592021008073	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
592021008074	Uncharacterized conserved protein [Function unknown]; Region: COG4198
592021008075	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
592021008076	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
592021008077	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
592021008078	putative ligand binding site [chemical binding]; other site
592021008079	putative NAD binding site [chemical binding]; other site
592021008080	putative catalytic site [active]
592021008081	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
592021008082	L-serine binding site [chemical binding]; other site
592021008083	ACT domain interface; other site
592021008084	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
592021008085	homodimer interface [polypeptide binding]; other site
592021008086	substrate-cofactor binding pocket; other site
592021008087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021008088	catalytic residue [active]
592021008089	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
592021008090	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
592021008091	RNA polymerase sigma factor SigM; Provisional; Region: PRK09644
592021008092	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021008093	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
592021008094	Uncharacterized conserved protein [Function unknown]; Region: COG2155
592021008095	Cupin domain; Region: Cupin_2; cl17218
592021008096	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
592021008097	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021008098	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
592021008099	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
592021008100	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
592021008101	active site
592021008102	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
592021008103	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
592021008104	A new structural DNA glycosylase; Region: AlkD_like; cd06561
592021008105	active site
592021008106	Protein of unknown function (DUF3895); Region: DUF3895; pfam13034
592021008107	S-layer homology domain; Region: SLH; pfam00395
592021008108	S-layer homology domain; Region: SLH; pfam00395
592021008109	S-layer homology domain; Region: SLH; pfam00395
592021008110	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
592021008111	putative metal binding site [ion binding]; other site
592021008112	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021008113	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
592021008114	NETI protein; Region: NETI; pfam14044
592021008115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021008116	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021008117	putative substrate translocation pore; other site
592021008118	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021008119	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
592021008120	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021008121	MarR family; Region: MarR_2; pfam12802
592021008122	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021008123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021008124	putative substrate translocation pore; other site
592021008125	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021008126	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021008127	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
592021008128	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021008129	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021008130	Walker A/P-loop; other site
592021008131	ATP binding site [chemical binding]; other site
592021008132	Q-loop/lid; other site
592021008133	ABC transporter signature motif; other site
592021008134	Walker B; other site
592021008135	D-loop; other site
592021008136	H-loop/switch region; other site
592021008137	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
592021008138	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021008139	putative DNA binding site [nucleotide binding]; other site
592021008140	putative Zn2+ binding site [ion binding]; other site
592021008141	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
592021008142	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021008143	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021008144	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
592021008145	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
592021008146	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
592021008147	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
592021008148	SWIM zinc finger; Region: SWIM; pfam04434
592021008149	YwiC-like protein; Region: YwiC; pfam14256
592021008150	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
592021008151	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
592021008152	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
592021008153	Walker A/P-loop; other site
592021008154	ATP binding site [chemical binding]; other site
592021008155	Q-loop/lid; other site
592021008156	ABC transporter signature motif; other site
592021008157	Walker B; other site
592021008158	D-loop; other site
592021008159	H-loop/switch region; other site
592021008160	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
592021008161	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
592021008162	Walker A/P-loop; other site
592021008163	ATP binding site [chemical binding]; other site
592021008164	Q-loop/lid; other site
592021008165	ABC transporter signature motif; other site
592021008166	Walker B; other site
592021008167	D-loop; other site
592021008168	H-loop/switch region; other site
592021008169	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
592021008170	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
592021008171	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
592021008172	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
592021008173	Predicted membrane protein [Function unknown]; Region: COG1288
592021008174	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
592021008175	Endonuclease I; Region: Endonuclease_1; pfam04231
592021008176	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
592021008177	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
592021008178	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021008179	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021008180	non-specific DNA binding site [nucleotide binding]; other site
592021008181	salt bridge; other site
592021008182	sequence-specific DNA binding site [nucleotide binding]; other site
592021008183	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
592021008184	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
592021008185	putative deacylase active site [active]
592021008186	histidyl-tRNA synthetase; Provisional; Region: PRK12420
592021008187	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
592021008188	dimer interface [polypeptide binding]; other site
592021008189	motif 1; other site
592021008190	active site
592021008191	motif 2; other site
592021008192	motif 3; other site
592021008193	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
592021008194	anticodon binding site; other site
592021008195	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021008196	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
592021008197	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
592021008198	dimer interface [polypeptide binding]; other site
592021008199	FMN binding site [chemical binding]; other site
592021008200	pyruvate kinase; Validated; Region: PRK06739
592021008201	active site
592021008202	domain interfaces; other site
592021008203	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
592021008204	classical (c) SDRs; Region: SDR_c; cd05233
592021008205	NAD(P) binding site [chemical binding]; other site
592021008206	active site
592021008207	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
592021008208	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021008209	Walker A/P-loop; other site
592021008210	ATP binding site [chemical binding]; other site
592021008211	Q-loop/lid; other site
592021008212	ABC transporter signature motif; other site
592021008213	Walker B; other site
592021008214	D-loop; other site
592021008215	H-loop/switch region; other site
592021008216	Protein of unknown function (DUF3796); Region: DUF3796; pfam12676
592021008217	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021008218	non-specific DNA binding site [nucleotide binding]; other site
592021008219	salt bridge; other site
592021008220	sequence-specific DNA binding site [nucleotide binding]; other site
592021008221	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
592021008222	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021008223	motif II; other site
592021008224	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
592021008225	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
592021008226	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
592021008227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021008228	Coenzyme A binding pocket [chemical binding]; other site
592021008229	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
592021008230	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
592021008231	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
592021008232	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021008233	putative metal binding site [ion binding]; other site
592021008234	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
592021008235	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
592021008236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021008237	putative substrate translocation pore; other site
592021008238	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021008239	maltose O-acetyltransferase; Provisional; Region: PRK10092
592021008240	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
592021008241	active site
592021008242	substrate binding site [chemical binding]; other site
592021008243	trimer interface [polypeptide binding]; other site
592021008244	CoA binding site [chemical binding]; other site
592021008245	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021008246	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021008247	Walker A/P-loop; other site
592021008248	ATP binding site [chemical binding]; other site
592021008249	Q-loop/lid; other site
592021008250	ABC transporter signature motif; other site
592021008251	Walker B; other site
592021008252	D-loop; other site
592021008253	H-loop/switch region; other site
592021008254	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
592021008255	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
592021008256	active site
592021008257	HIGH motif; other site
592021008258	dimer interface [polypeptide binding]; other site
592021008259	KMSKS motif; other site
592021008260	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464
592021008261	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
592021008262	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
592021008263	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
592021008264	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
592021008265	Domain of unknown function DUF20; Region: UPF0118; pfam01594
592021008266	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021008267	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021008268	Coenzyme A binding pocket [chemical binding]; other site
592021008269	ydaO/yuaA leader
592021008270	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021008271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021008272	S-adenosylmethionine binding site [chemical binding]; other site
592021008273	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
592021008274	CGNR zinc finger; Region: zf-CGNR; pfam11706
592021008275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021008276	multidrug resistance protein MdtH; Provisional; Region: PRK11646
592021008277	putative substrate translocation pore; other site
592021008278	Tetratricopeptide repeat; Region: TPR_16; pfam13432
592021008279	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021008280	TPR motif; other site
592021008281	binding surface
592021008282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
592021008283	binding surface
592021008284	TPR motif; other site
592021008285	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
592021008286	hypothetical protein; Provisional; Region: PRK04164
592021008287	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021008288	ATP synthase I chain; Region: ATP_synt_I; cl09170
592021008289	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
592021008290	Domain of unknown function DUF21; Region: DUF21; pfam01595
592021008291	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
592021008292	Transporter associated domain; Region: CorC_HlyC; smart01091
592021008293	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
592021008294	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021008295	DNA binding residues [nucleotide binding]
592021008296	putative dimer interface [polypeptide binding]; other site
592021008297	EamA-like transporter family; Region: EamA; pfam00892
592021008298	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
592021008299	EamA-like transporter family; Region: EamA; pfam00892
592021008300	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
592021008301	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
592021008302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
592021008303	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
592021008304	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
592021008305	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
592021008306	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
592021008307	N- and C-terminal domain interface [polypeptide binding]; other site
592021008308	active site
592021008309	catalytic site [active]
592021008310	metal binding site [ion binding]; metal-binding site
592021008311	carbohydrate binding site [chemical binding]; other site
592021008312	ATP binding site [chemical binding]; other site
592021008313	GntP family permease; Region: GntP_permease; pfam02447
592021008314	fructuronate transporter; Provisional; Region: PRK10034; cl15264
592021008315	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
592021008316	active site
592021008317	intersubunit interactions; other site
592021008318	catalytic residue [active]
592021008319	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
592021008320	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
592021008321	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
592021008322	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
592021008323	TPP-binding site [chemical binding]; other site
592021008324	dimer interface [polypeptide binding]; other site
592021008325	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
592021008326	PYR/PP interface [polypeptide binding]; other site
592021008327	dimer interface [polypeptide binding]; other site
592021008328	TPP binding site [chemical binding]; other site
592021008329	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
592021008330	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
592021008331	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
592021008332	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
592021008333	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
592021008334	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
592021008335	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
592021008336	putative NAD(P) binding site [chemical binding]; other site
592021008337	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
592021008338	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
592021008339	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
592021008340	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
592021008341	putative NAD(P) binding site [chemical binding]; other site
592021008342	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
592021008343	classical (c) SDRs; Region: SDR_c; cd05233
592021008344	NAD(P) binding site [chemical binding]; other site
592021008345	active site
592021008346	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
592021008347	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
592021008348	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
592021008349	active site
592021008350	Zn binding site [ion binding]; other site
592021008351	Viral enhancin protein; Region: Enhancin; pfam03272
592021008352	Peptidase M60-like family; Region: M60-like; pfam13402
592021008353	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
592021008354	dimer interface [polypeptide binding]; other site
592021008355	FMN binding site [chemical binding]; other site
592021008356	BNR repeat-like domain; Region: BNR_2; pfam13088
592021008357	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021008358	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021008359	active site
592021008360	catalytic tetrad [active]
592021008361	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
592021008362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021008363	putative substrate translocation pore; other site
592021008364	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
592021008365	active site 1 [active]
592021008366	dimer interface [polypeptide binding]; other site
592021008367	hexamer interface [polypeptide binding]; other site
592021008368	active site 2 [active]
592021008369	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
592021008370	hexamer interface [polypeptide binding]; other site
592021008371	active site 2 [active]
592021008372	hypothetical protein; Provisional; Region: PRK02487
592021008373	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021008374	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
592021008375	active site
592021008376	metal binding site [ion binding]; metal-binding site
592021008377	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
592021008378	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
592021008379	IDEAL domain; Region: IDEAL; pfam08858
592021008380	Transcriptional regulator; Region: Rrf2; pfam02082
592021008381	Rrf2 family protein; Region: rrf2_super; TIGR00738
592021008382	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
592021008383	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
592021008384	ArsC family; Region: ArsC; pfam03960
592021008385	putative catalytic residues [active]
592021008386	thiol/disulfide switch; other site
592021008387	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021008388	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021008389	dimerization interface [polypeptide binding]; other site
592021008390	putative DNA binding site [nucleotide binding]; other site
592021008391	putative Zn2+ binding site [ion binding]; other site
592021008392	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
592021008393	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021008394	DNA-binding site [nucleotide binding]; DNA binding site
592021008395	UTRA domain; Region: UTRA; pfam07702
592021008396	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
592021008397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
592021008398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021008399	S-adenosylmethionine binding site [chemical binding]; other site
592021008400	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021008401	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
592021008402	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021008403	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021008404	dimerization interface [polypeptide binding]; other site
592021008405	putative DNA binding site [nucleotide binding]; other site
592021008406	putative Zn2+ binding site [ion binding]; other site
592021008407	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021008408	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021008409	active site
592021008410	catalytic tetrad [active]
592021008411	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
592021008412	putative hydrophobic ligand binding site [chemical binding]; other site
592021008413	protein interface [polypeptide binding]; other site
592021008414	gate; other site
592021008415	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021008416	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
592021008417	Phosphotransferase enzyme family; Region: APH; pfam01636
592021008418	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
592021008419	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
592021008420	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
592021008421	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021008422	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021008423	Coenzyme A binding pocket [chemical binding]; other site
592021008424	C factor cell-cell signaling protein; Provisional; Region: PRK09009
592021008425	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
592021008426	NAD(P) binding site [chemical binding]; other site
592021008427	active site
592021008428	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021008429	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021008430	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
592021008431	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
592021008432	acyl-activating enzyme (AAE) consensus motif; other site
592021008433	AMP binding site [chemical binding]; other site
592021008434	active site
592021008435	CoA binding site [chemical binding]; other site
592021008436	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021008437	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021008438	dimerization interface [polypeptide binding]; other site
592021008439	putative DNA binding site [nucleotide binding]; other site
592021008440	putative Zn2+ binding site [ion binding]; other site
592021008441	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
592021008442	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
592021008443	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
592021008444	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
592021008445	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
592021008446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021008447	dimerization interface [polypeptide binding]; other site
592021008448	putative DNA binding site [nucleotide binding]; other site
592021008449	putative Zn2+ binding site [ion binding]; other site
592021008450	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
592021008451	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
592021008452	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021008453	CAAX protease self-immunity; Region: Abi; pfam02517
592021008454	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021008455	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021008456	Protein of unknown function (DUF3963); Region: DUF3963; pfam13124
592021008457	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
592021008458	Protein of unknown function (DUF805); Region: DUF805; pfam05656
592021008459	ABC-2 type transporter; Region: ABC2_membrane; cl17235
592021008460	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
592021008461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021008462	Walker A/P-loop; other site
592021008463	ATP binding site [chemical binding]; other site
592021008464	Q-loop/lid; other site
592021008465	ABC transporter signature motif; other site
592021008466	Walker B; other site
592021008467	D-loop; other site
592021008468	H-loop/switch region; other site
592021008469	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
592021008470	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021008471	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
592021008472	hydroxylamine reductase; Provisional; Region: PRK12310
592021008473	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
592021008474	ACS interaction site; other site
592021008475	CODH interaction site; other site
592021008476	metal cluster binding site [ion binding]; other site
592021008477	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021008478	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
592021008479	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
592021008480	active site
592021008481	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
592021008482	metal binding site [ion binding]; metal-binding site
592021008483	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
592021008484	hypothetical protein; Provisional; Region: PRK06771
592021008485	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021008486	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021008487	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
592021008488	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
592021008489	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
592021008490	dimer interface [polypeptide binding]; other site
592021008491	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021008492	ligand binding site [chemical binding]; other site
592021008493	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
592021008494	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
592021008495	ligand binding site [chemical binding]; other site
592021008496	flexible hinge region; other site
592021008497	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
592021008498	Protein of unknown function, DUF606; Region: DUF606; pfam04657
592021008499	Protein of unknown function, DUF606; Region: DUF606; pfam04657
592021008500	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021008501	putative transport protein YifK; Provisional; Region: PRK10746
592021008502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021008503	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
592021008504	putative substrate translocation pore; other site
592021008505	Haemolysin XhlA; Region: XhlA; pfam10779
592021008506	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
592021008507	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
592021008508	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
592021008509	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
592021008510	transmembrane helices; other site
592021008511	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021008512	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021008513	Coenzyme A binding pocket [chemical binding]; other site
592021008514	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021008515	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
592021008516	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021008517	ABC-ATPase subunit  interface; other site
592021008518	dimer interface [polypeptide binding]; other site
592021008519	putative PBP binding regions; other site
592021008520	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
592021008521	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021008522	ABC-ATPase subunit  interface; other site
592021008523	dimer interface [polypeptide binding]; other site
592021008524	putative PBP binding regions; other site
592021008525	Protein of unknown function (DUF817); Region: DUF817; pfam05675
592021008526	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
592021008527	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
592021008528	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
592021008529	DinB superfamily; Region: DinB_2; pfam12867
592021008530	DinB family; Region: DinB; cl17821
592021008531	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
592021008532	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
592021008533	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021008534	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021008535	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021008536	dimerization interface [polypeptide binding]; other site
592021008537	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
592021008538	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
592021008539	NADP binding site [chemical binding]; other site
592021008540	dimer interface [polypeptide binding]; other site
592021008541	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
592021008542	catalytic core [active]
592021008543	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021008544	Coenzyme A binding pocket [chemical binding]; other site
592021008545	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
592021008546	MutS domain III; Region: MutS_III; pfam05192
592021008547	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021008548	Walker A/P-loop; other site
592021008549	ATP binding site [chemical binding]; other site
592021008550	Q-loop/lid; other site
592021008551	ABC transporter signature motif; other site
592021008552	Walker B; other site
592021008553	D-loop; other site
592021008554	H-loop/switch region; other site
592021008555	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
592021008556	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
592021008557	active site
592021008558	Na/Ca binding site [ion binding]; other site
592021008559	catalytic site [active]
592021008560	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
592021008561	oligoendopeptidase F; Region: pepF; TIGR00181
592021008562	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
592021008563	active site
592021008564	Zn binding site [ion binding]; other site
592021008565	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
592021008566	Beta-lactamase; Region: Beta-lactamase; pfam00144
592021008567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021008568	putative substrate translocation pore; other site
592021008569	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021008570	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021008571	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021008572	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
592021008573	putative dimerization interface [polypeptide binding]; other site
592021008574	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
592021008575	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
592021008576	putative active site [active]
592021008577	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
592021008578	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
592021008579	active site
592021008580	catalytic site [active]
592021008581	metal binding site [ion binding]; metal-binding site
592021008582	FAD binding domain; Region: FAD_binding_3; pfam01494
592021008583	hypothetical protein; Provisional; Region: PRK07236
592021008584	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021008585	dimerization interface [polypeptide binding]; other site
592021008586	putative DNA binding site [nucleotide binding]; other site
592021008587	putative Zn2+ binding site [ion binding]; other site
592021008588	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
592021008589	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
592021008590	putative NAD(P) binding site [chemical binding]; other site
592021008591	Uncharacterized conserved protein [Function unknown]; Region: COG0397
592021008592	hypothetical protein; Validated; Region: PRK00029
592021008593	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
592021008594	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
592021008595	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
592021008596	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
592021008597	Sodium Bile acid symporter family; Region: SBF; cl17470
592021008598	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
592021008599	FAD binding domain; Region: FAD_binding_4; pfam01565
592021008600	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
592021008601	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
592021008602	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
592021008603	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
592021008604	trimer interface [polypeptide binding]; other site
592021008605	active site
592021008606	substrate binding site [chemical binding]; other site
592021008607	CoA binding site [chemical binding]; other site
592021008608	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
592021008609	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
592021008610	inhibitor-cofactor binding pocket; inhibition site
592021008611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021008612	catalytic residue [active]
592021008613	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
592021008614	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
592021008615	active site
592021008616	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
592021008617	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
592021008618	active site
592021008619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021008620	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021008621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
592021008622	enoyl-CoA hydratase; Provisional; Region: PRK06688
592021008623	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
592021008624	substrate binding site [chemical binding]; other site
592021008625	oxyanion hole (OAH) forming residues; other site
592021008626	trimer interface [polypeptide binding]; other site
592021008627	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
592021008628	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
592021008629	FOG: PKD repeat [General function prediction only]; Region: COG3291
592021008630	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
592021008631	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
592021008632	MgtC family; Region: MgtC; pfam02308
592021008633	Predicted acetyltransferase [General function prediction only]; Region: COG3981
592021008634	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021008635	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
592021008636	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
592021008637	putative metal binding site [ion binding]; other site
592021008638	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
592021008639	active site
592021008640	metal binding site [ion binding]; metal-binding site
592021008641	VanW like protein; Region: VanW; pfam04294
592021008642	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
592021008643	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
592021008644	exonuclease; Provisional; Region: PRK06722
592021008645	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
592021008646	active site
592021008647	catalytic site [active]
592021008648	substrate binding site [chemical binding]; other site
592021008649	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
592021008650	DNA-binding site [nucleotide binding]; DNA binding site
592021008651	RNA-binding motif; other site
592021008652	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
592021008653	flavodoxin; Provisional; Region: PRK06703
592021008654	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
592021008655	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
592021008656	nudix motif; other site
592021008657	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
592021008658	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
592021008659	trimer interface [polypeptide binding]; other site
592021008660	active site
592021008661	substrate binding site [chemical binding]; other site
592021008662	CoA binding site [chemical binding]; other site
592021008663	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008664	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008665	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008666	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008667	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008668	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008669	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008670	Domain of unknown function DUF11; Region: DUF11; cl17728
592021008671	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008672	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008673	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008674	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008675	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008676	short chain dehydrogenase; Provisional; Region: PRK06924
592021008677	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
592021008678	NADP binding site [chemical binding]; other site
592021008679	homodimer interface [polypeptide binding]; other site
592021008680	active site
592021008681	Predicted acetyltransferase [General function prediction only]; Region: COG3393
592021008682	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021008683	argininosuccinate lyase; Provisional; Region: PRK06705
592021008684	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
592021008685	active sites [active]
592021008686	tetramer interface [polypeptide binding]; other site
592021008687	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021008688	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021008689	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
592021008690	active site
592021008691	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
592021008692	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
592021008693	Na binding site [ion binding]; other site
592021008694	Protein of unknown function (DUF997); Region: DUF997; pfam06196
592021008695	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
592021008696	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
592021008697	NAD(P) binding site [chemical binding]; other site
592021008698	catalytic residues [active]
592021008699	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
592021008700	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
592021008701	NAD(P) binding site [chemical binding]; other site
592021008702	homotetramer interface [polypeptide binding]; other site
592021008703	homodimer interface [polypeptide binding]; other site
592021008704	active site
592021008705	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
592021008706	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
592021008707	Divergent PAP2 family; Region: DUF212; pfam02681
592021008708	Predicted permeases [General function prediction only]; Region: RarD; COG2962
592021008709	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
592021008710	antiporter inner membrane protein; Provisional; Region: PRK11670
592021008711	Domain of unknown function DUF59; Region: DUF59; pfam01883
592021008712	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
592021008713	Walker A motif; other site
592021008714	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
592021008715	MoaE interaction surface [polypeptide binding]; other site
592021008716	MoeB interaction surface [polypeptide binding]; other site
592021008717	thiocarboxylated glycine; other site
592021008718	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
592021008719	MoaE homodimer interface [polypeptide binding]; other site
592021008720	MoaD interaction [polypeptide binding]; other site
592021008721	active site residues [active]
592021008722	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
592021008723	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
592021008724	dimer interface [polypeptide binding]; other site
592021008725	putative functional site; other site
592021008726	putative MPT binding site; other site
592021008727	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
592021008728	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
592021008729	ATP binding site [chemical binding]; other site
592021008730	substrate interface [chemical binding]; other site
592021008731	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
592021008732	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
592021008733	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021008734	FeS/SAM binding site; other site
592021008735	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
592021008736	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
592021008737	Uncharacterized conserved protein [Function unknown]; Region: COG5609
592021008738	Uncharacterized conserved protein [Function unknown]; Region: COG2427
592021008739	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
592021008740	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
592021008741	catalytic loop [active]
592021008742	iron binding site [ion binding]; other site
592021008743	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
592021008744	4Fe-4S binding domain; Region: Fer4; pfam00037
592021008745	4Fe-4S binding domain; Region: Fer4; pfam00037
592021008746	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
592021008747	[4Fe-4S] binding site [ion binding]; other site
592021008748	molybdopterin cofactor binding site; other site
592021008749	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
592021008750	molybdopterin cofactor binding site; other site
592021008751	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
592021008752	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
592021008753	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
592021008754	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
592021008755	Tubulin like; Region: Tubulin_2; pfam13809
592021008756	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
592021008757	metal ion-dependent adhesion site (MIDAS); other site
592021008758	Methyltransferase domain; Region: Methyltransf_31; pfam13847
592021008759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021008760	S-adenosylmethionine binding site [chemical binding]; other site
592021008761	O-methyltransferase; Region: Methyltransf_2; pfam00891
592021008762	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021008763	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021008764	peptide binding site [polypeptide binding]; other site
592021008765	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021008766	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021008767	peptide binding site [polypeptide binding]; other site
592021008768	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
592021008769	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
592021008770	peptide binding site [polypeptide binding]; other site
592021008771	Transcriptional regulator [Transcription]; Region: LytR; COG1316
592021008772	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
592021008773	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021008774	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021008775	DNA binding residues [nucleotide binding]
592021008776	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021008777	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021008778	Walker A/P-loop; other site
592021008779	ATP binding site [chemical binding]; other site
592021008780	Q-loop/lid; other site
592021008781	ABC transporter signature motif; other site
592021008782	Walker B; other site
592021008783	D-loop; other site
592021008784	H-loop/switch region; other site
592021008785	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021008786	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021008787	putative oxidoreductase; Provisional; Region: PRK11579
592021008788	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
592021008789	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
592021008790	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
592021008791	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
592021008792	CAP-like domain; other site
592021008793	active site
592021008794	primary dimer interface [polypeptide binding]; other site
592021008795	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021008796	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021008797	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021008798	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
592021008799	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
592021008800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021008801	ATP binding site [chemical binding]; other site
592021008802	Mg2+ binding site [ion binding]; other site
592021008803	G-X-G motif; other site
592021008804	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
592021008805	anchoring element; other site
592021008806	dimer interface [polypeptide binding]; other site
592021008807	ATP binding site [chemical binding]; other site
592021008808	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
592021008809	active site
592021008810	putative metal-binding site [ion binding]; other site
592021008811	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
592021008812	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
592021008813	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
592021008814	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
592021008815	protein binding site [polypeptide binding]; other site
592021008816	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021008817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021008818	active site
592021008819	phosphorylation site [posttranslational modification]
592021008820	intermolecular recognition site; other site
592021008821	dimerization interface [polypeptide binding]; other site
592021008822	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021008823	DNA binding site [nucleotide binding]
592021008824	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
592021008825	Class III ribonucleotide reductase; Region: RNR_III; cd01675
592021008826	effector binding site; other site
592021008827	active site
592021008828	Zn binding site [ion binding]; other site
592021008829	glycine loop; other site
592021008830	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
592021008831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
592021008832	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
592021008833	active site
592021008834	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
592021008835	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
592021008836	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
592021008837	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
592021008838	active site
592021008839	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
592021008840	acid-soluble spore protein N; Provisional; Region: sspN; PRK09398
592021008841	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
592021008842	DNA polymerase III subunit epsilon; Validated; Region: PRK06807
592021008843	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
592021008844	active site
592021008845	catalytic site [active]
592021008846	substrate binding site [chemical binding]; other site
592021008847	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
592021008848	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
592021008849	catalytic residues [active]
592021008850	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
592021008851	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021008852	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021008853	Walker A/P-loop; other site
592021008854	ATP binding site [chemical binding]; other site
592021008855	Q-loop/lid; other site
592021008856	ABC transporter signature motif; other site
592021008857	Walker B; other site
592021008858	D-loop; other site
592021008859	H-loop/switch region; other site
592021008860	aconitate hydratase; Validated; Region: PRK09277
592021008861	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
592021008862	substrate binding site [chemical binding]; other site
592021008863	ligand binding site [chemical binding]; other site
592021008864	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
592021008865	substrate binding site [chemical binding]; other site
592021008866	acid-soluble spore protein O; Provisional; Region: sspO; PRK02984
592021008867	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
592021008868	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
592021008869	NodB motif; other site
592021008870	active site
592021008871	catalytic site [active]
592021008872	metal binding site [ion binding]; metal-binding site
592021008873	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
592021008874	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
592021008875	putative dimer interface [polypeptide binding]; other site
592021008876	BT1 family; Region: BT1; pfam03092
592021008877	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
592021008878	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
592021008879	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
592021008880	nudix motif; other site
592021008881	SAP domain; Region: SAP; pfam02037
592021008882	acetyl-CoA acetyltransferase; Provisional; Region: PRK06690
592021008883	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
592021008884	dimer interface [polypeptide binding]; other site
592021008885	active site
592021008886	acyl-CoA synthetase; Validated; Region: PRK07638
592021008887	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
592021008888	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
592021008889	acyl-activating enzyme (AAE) consensus motif; other site
592021008890	acyl-activating enzyme (AAE) consensus motif; other site
592021008891	AMP binding site [chemical binding]; other site
592021008892	active site
592021008893	CoA binding site [chemical binding]; other site
592021008894	BioY family; Region: BioY; pfam02632
592021008895	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
592021008896	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
592021008897	dimer interface [polypeptide binding]; other site
592021008898	acyl-activating enzyme (AAE) consensus motif; other site
592021008899	putative active site [active]
592021008900	AMP binding site [chemical binding]; other site
592021008901	putative CoA binding site [chemical binding]; other site
592021008902	GCN5-related N-acetyltransferases (GNAT) represent a large superfamily of functionally diverse enzymes that catalyze the transfer of an acetyl group from acetyl-Coenzyme A to the primary amine of a wide range of acceptor substrates. Members of this...; Region: GNAT; cl00443
592021008903	Coenzyme A binding pocket; other site
592021008904	S-layer homology domain; Region: SLH; pfam00395
592021008905	S-layer homology domain; Region: SLH; pfam00395
592021008906	S-layer homology domain; Region: SLH; pfam00395
592021008907	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
592021008908	active site
592021008909	catalytic motif [active]
592021008910	Zn binding site [ion binding]; other site
592021008911	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
592021008912	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
592021008913	amidase catalytic site [active]
592021008914	Zn binding residues [ion binding]; other site
592021008915	substrate binding site [chemical binding]; other site
592021008916	active site
592021008917	Protein phosphatase 2C; Region: PP2C_2; pfam13672
592021008918	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021008919	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021008920	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021008921	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
592021008922	dimer interface [polypeptide binding]; other site
592021008923	putative metal binding site [ion binding]; other site
592021008924	PAS domain S-box; Region: sensory_box; TIGR00229
592021008925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021008926	putative active site [active]
592021008927	heme pocket [chemical binding]; other site
592021008928	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
592021008929	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021008930	putative active site [active]
592021008931	heme pocket [chemical binding]; other site
592021008932	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021008933	dimer interface [polypeptide binding]; other site
592021008934	phosphorylation site [posttranslational modification]
592021008935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021008936	ATP binding site [chemical binding]; other site
592021008937	Mg2+ binding site [ion binding]; other site
592021008938	G-X-G motif; other site
592021008939	Predicted esterase [General function prediction only]; Region: COG0400
592021008940	putative hydrolase; Provisional; Region: PRK11460
592021008941	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
592021008942	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021008943	Zn binding site [ion binding]; other site
592021008944	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
592021008945	Zn binding site [ion binding]; other site
592021008946	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
592021008947	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
592021008948	Na binding site [ion binding]; other site
592021008949	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
592021008950	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
592021008951	active site
592021008952	FMN binding site [chemical binding]; other site
592021008953	substrate binding site [chemical binding]; other site
592021008954	3Fe-4S cluster binding site [ion binding]; other site
592021008955	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
592021008956	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
592021008957	FMN binding site [chemical binding]; other site
592021008958	active site
592021008959	substrate binding site [chemical binding]; other site
592021008960	catalytic residue [active]
592021008961	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
592021008962	agmatinase; Region: agmatinase; TIGR01230
592021008963	Agmatinase-like family; Region: Agmatinase-like; cd09990
592021008964	active site
592021008965	oligomer interface [polypeptide binding]; other site
592021008966	Mn binding site [ion binding]; other site
592021008967	imidazolonepropionase; Validated; Region: PRK09356
592021008968	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
592021008969	active site
592021008970	urocanate hydratase; Provisional; Region: PRK05414
592021008971	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
592021008972	active sites [active]
592021008973	tetramer interface [polypeptide binding]; other site
592021008974	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
592021008975	hexamer interface [polypeptide binding]; other site
592021008976	RNA binding site [nucleotide binding]; other site
592021008977	Histidine-zinc binding site [chemical binding]; other site
592021008978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021008979	S-adenosylmethionine binding site [chemical binding]; other site
592021008980	DJ-1 family protein; Region: not_thiJ; TIGR01383
592021008981	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
592021008982	conserved cys residue [active]
592021008983	AAA domain; Region: AAA_28; pfam13521
592021008984	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
592021008985	active site
592021008986	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
592021008987	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008988	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008989	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008990	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008991	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008992	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008993	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008994	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008995	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008996	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008997	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008998	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021008999	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021009000	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021009001	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021009002	conserved repeat domain; Region: B_ant_repeat; TIGR01451
592021009003	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
592021009004	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
592021009005	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
592021009006	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
592021009007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021009008	The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452
592021009009	putative dimerization interface [polypeptide binding]; other site
592021009010	putative substrate binding pocket [chemical binding]; other site
592021009011	holin-like protein; Validated; Region: PRK01658
592021009012	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
592021009013	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
592021009014	nudix motif; other site
592021009015	Domain of unknown function (DUF3903); Region: DUF3903; pfam13043
592021009016	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
592021009017	amidase catalytic site [active]
592021009018	Zn binding residues [ion binding]; other site
592021009019	substrate binding site [chemical binding]; other site
592021009020	S-layer homology domain; Region: SLH; pfam00395
592021009021	S-layer homology domain; Region: SLH; pfam00395
592021009022	S-layer homology domain; Region: SLH; pfam00395
592021009023	Nuclease-related domain; Region: NERD; pfam08378
592021009024	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
592021009025	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021009026	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
592021009027	Walker A/P-loop; other site
592021009028	ATP binding site [chemical binding]; other site
592021009029	Q-loop/lid; other site
592021009030	ABC transporter signature motif; other site
592021009031	Walker B; other site
592021009032	D-loop; other site
592021009033	H-loop/switch region; other site
592021009034	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021009035	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
592021009036	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021009037	Walker A/P-loop; other site
592021009038	ATP binding site [chemical binding]; other site
592021009039	Q-loop/lid; other site
592021009040	ABC transporter signature motif; other site
592021009041	Walker B; other site
592021009042	D-loop; other site
592021009043	H-loop/switch region; other site
592021009044	hypothetical protein; Provisional; Region: PRK01844
592021009045	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
592021009046	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
592021009047	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
592021009048	TPP-binding site [chemical binding]; other site
592021009049	dimer interface [polypeptide binding]; other site
592021009050	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
592021009051	PYR/PP interface [polypeptide binding]; other site
592021009052	dimer interface [polypeptide binding]; other site
592021009053	TPP binding site [chemical binding]; other site
592021009054	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
592021009055	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
592021009056	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
592021009057	Probable transposase; Region: OrfB_IS605; pfam01385
592021009058	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
592021009059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021009060	dimer interface [polypeptide binding]; other site
592021009061	conserved gate region; other site
592021009062	ABC-ATPase subunit interface; other site
592021009063	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
592021009064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021009065	dimer interface [polypeptide binding]; other site
592021009066	conserved gate region; other site
592021009067	ABC-ATPase subunit interface; other site
592021009068	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
592021009069	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
592021009070	Walker A/P-loop; other site
592021009071	ATP binding site [chemical binding]; other site
592021009072	Q-loop/lid; other site
592021009073	ABC transporter signature motif; other site
592021009074	Walker B; other site
592021009075	D-loop; other site
592021009076	H-loop/switch region; other site
592021009077	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
592021009078	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
592021009079	membrane-bound complex binding site; other site
592021009080	hypothetical protein; Provisional; Region: PRK01546
592021009081	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
592021009082	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
592021009083	catalytic residues [active]
592021009084	catalytic nucleophile [active]
592021009085	LexA repressor; Validated; Region: PRK00215
592021009086	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021009087	putative DNA binding site [nucleotide binding]; other site
592021009088	putative Zn2+ binding site [ion binding]; other site
592021009089	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
592021009090	Catalytic site [active]
592021009091	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
592021009092	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
592021009093	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
592021009094	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021009095	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
592021009096	Tetratricopeptide repeat; Region: TPR_12; pfam13424
592021009097	Helix-turn-helix domain; Region: HTH_17; pfam12728
592021009098	Helix-turn-helix domain; Region: HTH_17; pfam12728
592021009099	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
592021009100	amidase catalytic site [active]
592021009101	Zn binding residues [ion binding]; other site
592021009102	substrate binding site [chemical binding]; other site
592021009103	Bacterial SH3 domain; Region: SH3_3; cl17532
592021009104	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021009105	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
592021009106	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
592021009107	Phage-related protein [Function unknown]; Region: COG5412
592021009108	membrane protein P6; Region: PHA01399
592021009109	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
592021009110	DsrH like protein; Region: DsrH; cl17347
592021009111	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
592021009112	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
592021009113	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
592021009114	Phage capsid family; Region: Phage_capsid; pfam05065
592021009115	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
592021009116	Phage portal protein; Region: Phage_portal; pfam04860
592021009117	Phage-related protein [Function unknown]; Region: COG4695; cl01923
592021009118	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
592021009119	HNH endonuclease; Region: HNH; pfam01844
592021009120	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
592021009121	Helix-turn-helix domain; Region: HTH_17; pfam12728
592021009122	HNH endonuclease; Region: HNH_2; pfam13391
592021009123	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
592021009124	homodimer interface [polypeptide binding]; other site
592021009125	chemical substrate binding site [chemical binding]; other site
592021009126	oligomer interface [polypeptide binding]; other site
592021009127	metal binding site [ion binding]; metal-binding site
592021009128	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
592021009129	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
592021009130	active site
592021009131	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021009132	sequence-specific DNA binding site [nucleotide binding]; other site
592021009133	salt bridge; other site
592021009134	AIPR protein; Region: AIPR; pfam10592
592021009135	positive control sigma-like factor; Validated; Region: PRK06930
592021009136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021009137	DNA binding residues [nucleotide binding]
592021009138	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
592021009139	PGAP1-like protein; Region: PGAP1; pfam07819
592021009140	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
592021009141	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
592021009142	thymidylate synthase, flavin-dependent; Region: thyX; TIGR02170
592021009143	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
592021009144	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
592021009145	cofactor binding site; other site
592021009146	DNA binding site [nucleotide binding]
592021009147	substrate interaction site [chemical binding]; other site
592021009148	dUTPase; Region: dUTPase_2; pfam08761
592021009149	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
592021009150	active site
592021009151	homodimer interface [polypeptide binding]; other site
592021009152	metal binding site [ion binding]; metal-binding site
592021009153	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
592021009154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021009155	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
592021009156	Walker A motif; other site
592021009157	ATP binding site [chemical binding]; other site
592021009158	Walker B motif; other site
592021009159	phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220
592021009160	Protein of unknown function (DUF1071); Region: DUF1071; pfam06378
592021009161	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
592021009162	Domain of unknown function (DUF771); Region: DUF771; pfam05595
592021009163	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
592021009164	ORF6C domain; Region: ORF6C; pfam10552
592021009165	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021009166	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021009167	non-specific DNA binding site [nucleotide binding]; other site
592021009168	salt bridge; other site
592021009169	sequence-specific DNA binding site [nucleotide binding]; other site
592021009170	Domain of unknown function (DUF955); Region: DUF955; cl01076
592021009171	glutamine synthetase, type I; Region: GlnA; TIGR00653
592021009172	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
592021009173	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
592021009174	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
592021009175	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021009176	DNA binding residues [nucleotide binding]
592021009177	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
592021009178	Aluminium resistance protein; Region: Alum_res; pfam06838
592021009179	Predicted membrane protein [Function unknown]; Region: COG2860
592021009180	UPF0126 domain; Region: UPF0126; pfam03458
592021009181	UPF0126 domain; Region: UPF0126; pfam03458
592021009182	stage V sporulation protein K; Region: spore_V_K; TIGR02881
592021009183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021009184	Walker A motif; other site
592021009185	ATP binding site [chemical binding]; other site
592021009186	Walker B motif; other site
592021009187	arginine finger; other site
592021009188	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
592021009189	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
592021009190	active site
592021009191	catalytic residues [active]
592021009192	DNA binding site [nucleotide binding]
592021009193	Int/Topo IB signature motif; other site
592021009194	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
592021009195	bacterial Hfq-like; Region: Hfq; cd01716
592021009196	hexamer interface [polypeptide binding]; other site
592021009197	Sm1 motif; other site
592021009198	RNA binding site [nucleotide binding]; other site
592021009199	Sm2 motif; other site
592021009200	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
592021009201	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
592021009202	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021009203	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021009204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
592021009205	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
592021009206	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
592021009207	active site
592021009208	phosphorylation site [posttranslational modification]
592021009209	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
592021009210	active site
592021009211	P-loop; other site
592021009212	phosphorylation site [posttranslational modification]
592021009213	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
592021009214	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
592021009215	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
592021009216	putative substrate binding site [chemical binding]; other site
592021009217	putative ATP binding site [chemical binding]; other site
592021009218	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
592021009219	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
592021009220	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
592021009221	Predicted membrane protein [Function unknown]; Region: COG2322
592021009222	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
592021009223	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
592021009224	Glyco_18 domain; Region: Glyco_18; smart00636
592021009225	putative active site [active]
592021009226	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
592021009227	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
592021009228	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
592021009229	putative active site [active]
592021009230	putative metal binding site [ion binding]; other site
592021009231	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
592021009232	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
592021009233	IHF dimer interface [polypeptide binding]; other site
592021009234	IHF - DNA interface [nucleotide binding]; other site
592021009235	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
592021009236	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
592021009237	metal-binding site [ion binding]
592021009238	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
592021009239	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
592021009240	metal-binding site [ion binding]
592021009241	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
592021009242	Soluble P-type ATPase [General function prediction only]; Region: COG4087
592021009243	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
592021009244	putative homodimer interface [polypeptide binding]; other site
592021009245	putative homotetramer interface [polypeptide binding]; other site
592021009246	putative allosteric switch controlling residues; other site
592021009247	putative metal binding site [ion binding]; other site
592021009248	putative homodimer-homodimer interface [polypeptide binding]; other site
592021009249	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
592021009250	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
592021009251	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
592021009252	Walker A/P-loop; other site
592021009253	ATP binding site [chemical binding]; other site
592021009254	Q-loop/lid; other site
592021009255	ABC transporter signature motif; other site
592021009256	Walker B; other site
592021009257	D-loop; other site
592021009258	H-loop/switch region; other site
592021009259	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
592021009260	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021009261	ABC-ATPase subunit  interface; other site
592021009262	dimer interface [polypeptide binding]; other site
592021009263	putative PBP binding regions; other site
592021009264	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
592021009265	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021009266	ABC-ATPase subunit  interface; other site
592021009267	dimer interface [polypeptide binding]; other site
592021009268	putative PBP binding regions; other site
592021009269	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
592021009270	active site
592021009271	putative catalytic site [active]
592021009272	DNA binding site [nucleotide binding]
592021009273	putative phosphate binding site [ion binding]; other site
592021009274	metal binding site A [ion binding]; metal-binding site
592021009275	AP binding site [nucleotide binding]; other site
592021009276	metal binding site B [ion binding]; metal-binding site
592021009277	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
592021009278	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
592021009279	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021009280	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021009281	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
592021009282	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
592021009283	DNA binding site [nucleotide binding]
592021009284	active site
592021009285	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
592021009286	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
592021009287	endonuclease III; Region: ENDO3c; smart00478
592021009288	minor groove reading motif; other site
592021009289	helix-hairpin-helix signature motif; other site
592021009290	substrate binding pocket [chemical binding]; other site
592021009291	active site
592021009292	peptidase T; Region: peptidase-T; TIGR01882
592021009293	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
592021009294	metal binding site [ion binding]; metal-binding site
592021009295	dimer interface [polypeptide binding]; other site
592021009296	Predicted membrane protein [Function unknown]; Region: COG2364
592021009297	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021009298	hypothetical protein; Provisional; Region: PRK06764
592021009299	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
592021009300	catalytic core [active]
592021009301	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021009302	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021009303	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
592021009304	active site
592021009305	PAS domain S-box; Region: sensory_box; TIGR00229
592021009306	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021009307	putative active site [active]
592021009308	heme pocket [chemical binding]; other site
592021009309	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
592021009310	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021009311	metal binding site [ion binding]; metal-binding site
592021009312	active site
592021009313	I-site; other site
592021009314	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
592021009315	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
592021009316	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
592021009317	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
592021009318	holin-like protein; Validated; Region: PRK01658
592021009319	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
592021009320	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021009321	DNA-binding site [nucleotide binding]; DNA binding site
592021009322	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021009323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021009324	homodimer interface [polypeptide binding]; other site
592021009325	catalytic residue [active]
592021009326	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021009327	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
592021009328	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
592021009329	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
592021009330	active site
592021009331	catalytic site [active]
592021009332	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
592021009333	putative active site [active]
592021009334	putative catalytic triad [active]
592021009335	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
592021009336	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
592021009337	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
592021009338	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
592021009339	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
592021009340	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
592021009341	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
592021009342	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
592021009343	Sulfatase; Region: Sulfatase; pfam00884
592021009344	Tetratricopeptide repeat; Region: TPR_16; pfam13432
592021009345	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021009346	binding surface
592021009347	TPR motif; other site
592021009348	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
592021009349	G1 box; other site
592021009350	GTP/Mg2+ binding site [chemical binding]; other site
592021009351	Switch I region; other site
592021009352	G3 box; other site
592021009353	Switch II region; other site
592021009354	G4 box; other site
592021009355	G5 box; other site
592021009356	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
592021009357	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
592021009358	active site
592021009359	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021009360	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021009361	dimer interface [polypeptide binding]; other site
592021009362	phosphorylation site [posttranslational modification]
592021009363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021009364	ATP binding site [chemical binding]; other site
592021009365	Mg2+ binding site [ion binding]; other site
592021009366	G-X-G motif; other site
592021009367	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021009368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021009369	active site
592021009370	phosphorylation site [posttranslational modification]
592021009371	intermolecular recognition site; other site
592021009372	dimerization interface [polypeptide binding]; other site
592021009373	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021009374	DNA binding site [nucleotide binding]
592021009375	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
592021009376	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
592021009377	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
592021009378	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
592021009379	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
592021009380	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
592021009381	Walker A/P-loop; other site
592021009382	ATP binding site [chemical binding]; other site
592021009383	Q-loop/lid; other site
592021009384	ABC transporter signature motif; other site
592021009385	Walker B; other site
592021009386	D-loop; other site
592021009387	H-loop/switch region; other site
592021009388	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
592021009389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021009390	ATP binding site [chemical binding]; other site
592021009391	Mg2+ binding site [ion binding]; other site
592021009392	G-X-G motif; other site
592021009393	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
592021009394	ATP binding site [chemical binding]; other site
592021009395	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
592021009396	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
592021009397	MutS domain I; Region: MutS_I; pfam01624
592021009398	MutS domain II; Region: MutS_II; pfam05188
592021009399	MutS domain III; Region: MutS_III; pfam05192
592021009400	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
592021009401	Walker A/P-loop; other site
592021009402	ATP binding site [chemical binding]; other site
592021009403	Q-loop/lid; other site
592021009404	ABC transporter signature motif; other site
592021009405	Walker B; other site
592021009406	D-loop; other site
592021009407	H-loop/switch region; other site
592021009408	Outer spore coat protein E (CotE); Region: CotE; pfam10628
592021009409	Predicted membrane protein [Function unknown]; Region: COG4550
592021009410	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
592021009411	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
592021009412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021009413	FeS/SAM binding site; other site
592021009414	TRAM domain; Region: TRAM; pfam01938
592021009415	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
592021009416	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
592021009417	TPP-binding site [chemical binding]; other site
592021009418	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
592021009419	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
592021009420	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
592021009421	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
592021009422	dimer interface [polypeptide binding]; other site
592021009423	PYR/PP interface [polypeptide binding]; other site
592021009424	TPP binding site [chemical binding]; other site
592021009425	substrate binding site [chemical binding]; other site
592021009426	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
592021009427	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
592021009428	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
592021009429	active site
592021009430	dimer interface [polypeptide binding]; other site
592021009431	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
592021009432	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
592021009433	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
592021009434	putative active site [active]
592021009435	metal binding site [ion binding]; metal-binding site
592021009436	homodimer binding site [polypeptide binding]; other site
592021009437	phosphodiesterase; Provisional; Region: PRK12704
592021009438	Uncharacterized conserved protein [Function unknown]; Region: COG3334
592021009439	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021009440	Zn2+ binding site [ion binding]; other site
592021009441	Mg2+ binding site [ion binding]; other site
592021009442	recA bacterial DNA recombination protein; Region: RecA; cl17211
592021009443	recA bacterial DNA recombination protein; Region: RecA; cl17211
592021009444	competence damage-inducible protein A; Provisional; Region: PRK00549
592021009445	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
592021009446	putative MPT binding site; other site
592021009447	Competence-damaged protein; Region: CinA; pfam02464
592021009448	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
592021009449	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
592021009450	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021009451	non-specific DNA binding site [nucleotide binding]; other site
592021009452	salt bridge; other site
592021009453	sequence-specific DNA binding site [nucleotide binding]; other site
592021009454	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
592021009455	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
592021009456	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
592021009457	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
592021009458	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
592021009459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
592021009460	NAD(P) binding site [chemical binding]; other site
592021009461	active site
592021009462	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
592021009463	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
592021009464	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
592021009465	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
592021009466	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
592021009467	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
592021009468	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
592021009469	Walker A/P-loop; other site
592021009470	ATP binding site [chemical binding]; other site
592021009471	Q-loop/lid; other site
592021009472	ABC transporter signature motif; other site
592021009473	Walker B; other site
592021009474	D-loop; other site
592021009475	H-loop/switch region; other site
592021009476	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
592021009477	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
592021009478	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
592021009479	ligand binding site [chemical binding]; other site
592021009480	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
592021009481	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021009482	DNA-binding site [nucleotide binding]; DNA binding site
592021009483	UTRA domain; Region: UTRA; pfam07702
592021009484	Tetraspanin family; Region: Tetraspannin; pfam00335
592021009485	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
592021009486	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
592021009487	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
592021009488	YlzJ-like protein; Region: YlzJ; pfam14035
592021009489	Clp protease; Region: CLP_protease; pfam00574
592021009490	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
592021009491	active site
592021009492	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
592021009493	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021009494	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
592021009495	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
592021009496	dihydrodipicolinate synthase; Region: dapA; TIGR00674
592021009497	dimer interface [polypeptide binding]; other site
592021009498	active site
592021009499	catalytic residue [active]
592021009500	aspartate kinase I; Reviewed; Region: PRK08210
592021009501	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
592021009502	nucleotide binding site [chemical binding]; other site
592021009503	substrate binding site [chemical binding]; other site
592021009504	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
592021009505	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
592021009506	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
592021009507	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
592021009508	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
592021009509	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
592021009510	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
592021009511	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
592021009512	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
592021009513	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
592021009514	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
592021009515	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
592021009516	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
592021009517	NodB motif; other site
592021009518	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
592021009519	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
592021009520	RNase E interface [polypeptide binding]; other site
592021009521	trimer interface [polypeptide binding]; other site
592021009522	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
592021009523	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
592021009524	RNase E interface [polypeptide binding]; other site
592021009525	trimer interface [polypeptide binding]; other site
592021009526	active site
592021009527	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
592021009528	putative nucleic acid binding region [nucleotide binding]; other site
592021009529	G-X-X-G motif; other site
592021009530	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
592021009531	RNA binding site [nucleotide binding]; other site
592021009532	domain interface; other site
592021009533	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
592021009534	16S/18S rRNA binding site [nucleotide binding]; other site
592021009535	S13e-L30e interaction site [polypeptide binding]; other site
592021009536	25S rRNA binding site [nucleotide binding]; other site
592021009537	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
592021009538	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
592021009539	active site
592021009540	Riboflavin kinase; Region: Flavokinase; smart00904
592021009541	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
592021009542	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
592021009543	RNA binding site [nucleotide binding]; other site
592021009544	active site
592021009545	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
592021009546	Protein of unknown function (DUF503); Region: DUF503; pfam04456
592021009547	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
592021009548	translation initiation factor IF-2; Region: IF-2; TIGR00487
592021009549	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
592021009550	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
592021009551	G1 box; other site
592021009552	putative GEF interaction site [polypeptide binding]; other site
592021009553	GTP/Mg2+ binding site [chemical binding]; other site
592021009554	Switch I region; other site
592021009555	G2 box; other site
592021009556	G3 box; other site
592021009557	Switch II region; other site
592021009558	G4 box; other site
592021009559	G5 box; other site
592021009560	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
592021009561	Translation-initiation factor 2; Region: IF-2; pfam11987
592021009562	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
592021009563	hypothetical protein; Provisional; Region: PRK07714
592021009564	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
592021009565	putative RNA binding cleft [nucleotide binding]; other site
592021009566	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
592021009567	NusA N-terminal domain; Region: NusA_N; pfam08529
592021009568	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
592021009569	RNA binding site [nucleotide binding]; other site
592021009570	homodimer interface [polypeptide binding]; other site
592021009571	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
592021009572	G-X-X-G motif; other site
592021009573	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
592021009574	G-X-X-G motif; other site
592021009575	ribosome maturation protein RimP; Reviewed; Region: PRK00092
592021009576	Sm and related proteins; Region: Sm_like; cl00259
592021009577	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
592021009578	putative oligomer interface [polypeptide binding]; other site
592021009579	putative RNA binding site [nucleotide binding]; other site
592021009580	DNA polymerase III PolC; Validated; Region: polC; PRK00448
592021009581	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
592021009582	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
592021009583	generic binding surface II; other site
592021009584	generic binding surface I; other site
592021009585	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
592021009586	active site
592021009587	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
592021009588	active site
592021009589	catalytic site [active]
592021009590	substrate binding site [chemical binding]; other site
592021009591	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
592021009592	prolyl-tRNA synthetase; Provisional; Region: PRK09194
592021009593	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
592021009594	dimer interface [polypeptide binding]; other site
592021009595	motif 1; other site
592021009596	active site
592021009597	motif 2; other site
592021009598	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
592021009599	putative deacylase active site [active]
592021009600	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
592021009601	active site
592021009602	motif 3; other site
592021009603	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
592021009604	anticodon binding site; other site
592021009605	RIP metalloprotease RseP; Region: TIGR00054
592021009606	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
592021009607	active site
592021009608	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
592021009609	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
592021009610	protein binding site [polypeptide binding]; other site
592021009611	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
592021009612	putative substrate binding region [chemical binding]; other site
592021009613	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
592021009614	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
592021009615	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
592021009616	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
592021009617	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
592021009618	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
592021009619	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
592021009620	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
592021009621	catalytic residue [active]
592021009622	putative FPP diphosphate  binding site; other site
592021009623	putative FPP binding hydrophobic cleft; other site
592021009624	dimer interface [polypeptide binding]; other site
592021009625	putative IPP diphosphate binding site; other site
592021009626	ribosome recycling factor; Reviewed; Region: frr; PRK00083
592021009627	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
592021009628	hinge region; other site
592021009629	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
592021009630	putative nucleotide binding site [chemical binding]; other site
592021009631	uridine monophosphate binding site [chemical binding]; other site
592021009632	homohexameric interface [polypeptide binding]; other site
592021009633	elongation factor Ts; Provisional; Region: tsf; PRK09377
592021009634	UBA/TS-N domain; Region: UBA; pfam00627
592021009635	Elongation factor TS; Region: EF_TS; pfam00889
592021009636	Elongation factor TS; Region: EF_TS; pfam00889
592021009637	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
592021009638	rRNA interaction site [nucleotide binding]; other site
592021009639	S8 interaction site; other site
592021009640	putative laminin-1 binding site; other site
592021009641	transcriptional repressor CodY; Validated; Region: PRK04158
592021009642	CodY GAF-like domain; Region: CodY; pfam06018
592021009643	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
592021009644	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
592021009645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021009646	Walker A motif; other site
592021009647	ATP binding site [chemical binding]; other site
592021009648	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
592021009649	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
592021009650	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
592021009651	active site
592021009652	HslU subunit interaction site [polypeptide binding]; other site
592021009653	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
592021009654	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
592021009655	active site
592021009656	Int/Topo IB signature motif; other site
592021009657	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
592021009658	Glucose inhibited division protein A; Region: GIDA; pfam01134
592021009659	DNA topoisomerase I; Validated; Region: PRK05582
592021009660	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
592021009661	active site
592021009662	interdomain interaction site; other site
592021009663	putative metal-binding site [ion binding]; other site
592021009664	nucleotide binding site [chemical binding]; other site
592021009665	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
592021009666	domain I; other site
592021009667	DNA binding groove [nucleotide binding]
592021009668	phosphate binding site [ion binding]; other site
592021009669	domain II; other site
592021009670	domain III; other site
592021009671	nucleotide binding site [chemical binding]; other site
592021009672	catalytic site [active]
592021009673	domain IV; other site
592021009674	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
592021009675	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
592021009676	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
592021009677	CoA binding domain; Region: CoA_binding; smart00881
592021009678	CoA-ligase; Region: Ligase_CoA; pfam00549
592021009679	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
592021009680	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
592021009681	CoA-ligase; Region: Ligase_CoA; pfam00549
592021009682	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
592021009683	RNA/DNA hybrid binding site [nucleotide binding]; other site
592021009684	active site
592021009685	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
592021009686	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
592021009687	GTP/Mg2+ binding site [chemical binding]; other site
592021009688	G4 box; other site
592021009689	G5 box; other site
592021009690	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
592021009691	G1 box; other site
592021009692	G1 box; other site
592021009693	GTP/Mg2+ binding site [chemical binding]; other site
592021009694	Switch I region; other site
592021009695	G2 box; other site
592021009696	G2 box; other site
592021009697	G3 box; other site
592021009698	G3 box; other site
592021009699	Switch II region; other site
592021009700	Switch II region; other site
592021009701	G4 box; other site
592021009702	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
592021009703	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
592021009704	Catalytic site [active]
592021009705	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
592021009706	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
592021009707	Ribosomal protein L19 leader
592021009708	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
592021009709	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
592021009710	RimM N-terminal domain; Region: RimM; pfam01782
592021009711	PRC-barrel domain; Region: PRC; pfam05239
592021009712	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
592021009713	KH domain; Region: KH_4; pfam13083
592021009714	G-X-X-G motif; other site
592021009715	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
592021009716	signal recognition particle protein; Provisional; Region: PRK10867
592021009717	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
592021009718	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
592021009719	P loop; other site
592021009720	GTP binding site [chemical binding]; other site
592021009721	Signal peptide binding domain; Region: SRP_SPB; pfam02978
592021009722	putative DNA-binding protein; Validated; Region: PRK00118
592021009723	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
592021009724	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
592021009725	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
592021009726	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
592021009727	P loop; other site
592021009728	GTP binding site [chemical binding]; other site
592021009729	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
592021009730	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
592021009731	Walker A/P-loop; other site
592021009732	ATP binding site [chemical binding]; other site
592021009733	Q-loop/lid; other site
592021009734	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
592021009735	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
592021009736	ABC transporter signature motif; other site
592021009737	Walker B; other site
592021009738	D-loop; other site
592021009739	H-loop/switch region; other site
592021009740	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
592021009741	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
592021009742	dimerization interface [polypeptide binding]; other site
592021009743	active site
592021009744	metal binding site [ion binding]; metal-binding site
592021009745	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
592021009746	dsRNA binding site [nucleotide binding]; other site
592021009747	acyl carrier protein; Provisional; Region: acpP; PRK00982
592021009748	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
592021009749	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
592021009750	NAD(P) binding site [chemical binding]; other site
592021009751	homotetramer interface [polypeptide binding]; other site
592021009752	homodimer interface [polypeptide binding]; other site
592021009753	active site
592021009754	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
592021009755	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
592021009756	putative phosphate acyltransferase; Provisional; Region: PRK05331
592021009757	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
592021009758	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
592021009759	active site 2 [active]
592021009760	active site 1 [active]
592021009761	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
592021009762	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
592021009763	generic binding surface II; other site
592021009764	ssDNA binding site; other site
592021009765	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021009766	ATP binding site [chemical binding]; other site
592021009767	putative Mg++ binding site [ion binding]; other site
592021009768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021009769	nucleotide binding region [chemical binding]; other site
592021009770	ATP-binding site [chemical binding]; other site
592021009771	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
592021009772	DAK2 domain; Region: Dak2; pfam02734
592021009773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
592021009774	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
592021009775	Thiamine pyrophosphokinase; Region: TPK; cd07995
592021009776	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
592021009777	active site
592021009778	dimerization interface [polypeptide binding]; other site
592021009779	thiamine binding site [chemical binding]; other site
592021009780	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
592021009781	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
592021009782	substrate binding site [chemical binding]; other site
592021009783	hexamer interface [polypeptide binding]; other site
592021009784	metal binding site [ion binding]; metal-binding site
592021009785	GTPase RsgA; Reviewed; Region: PRK00098
592021009786	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
592021009787	RNA binding site [nucleotide binding]; other site
592021009788	homodimer interface [polypeptide binding]; other site
592021009789	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
592021009790	GTPase/Zn-binding domain interface [polypeptide binding]; other site
592021009791	GTP/Mg2+ binding site [chemical binding]; other site
592021009792	G4 box; other site
592021009793	G5 box; other site
592021009794	G1 box; other site
592021009795	Switch I region; other site
592021009796	G2 box; other site
592021009797	G3 box; other site
592021009798	Switch II region; other site
592021009799	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
592021009800	Catalytic domain of Protein Kinases; Region: PKc; cd00180
592021009801	active site
592021009802	ATP binding site [chemical binding]; other site
592021009803	substrate binding site [chemical binding]; other site
592021009804	activation loop (A-loop); other site
592021009805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
592021009806	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
592021009807	PASTA domain; Region: PASTA; pfam03793
592021009808	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
592021009809	Protein phosphatase 2C; Region: PP2C; pfam00481
592021009810	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
592021009811	active site
592021009812	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
592021009813	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021009814	FeS/SAM binding site; other site
592021009815	16S rRNA methyltransferase B; Provisional; Region: PRK14902
592021009816	NusB family; Region: NusB; pfam01029
592021009817	putative RNA binding site [nucleotide binding]; other site
592021009818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021009819	S-adenosylmethionine binding site [chemical binding]; other site
592021009820	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
592021009821	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
592021009822	putative active site [active]
592021009823	substrate binding site [chemical binding]; other site
592021009824	putative cosubstrate binding site; other site
592021009825	catalytic site [active]
592021009826	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
592021009827	substrate binding site [chemical binding]; other site
592021009828	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
592021009829	active site
592021009830	catalytic residues [active]
592021009831	metal binding site [ion binding]; metal-binding site
592021009832	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021009833	primosomal protein N' Region: priA; TIGR00595
592021009834	ATP binding site [chemical binding]; other site
592021009835	putative Mg++ binding site [ion binding]; other site
592021009836	helicase superfamily c-terminal domain; Region: HELICc; smart00490
592021009837	nucleotide binding region [chemical binding]; other site
592021009838	ATP-binding site [chemical binding]; other site
592021009839	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
592021009840	Flavoprotein; Region: Flavoprotein; pfam02441
592021009841	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
592021009842	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
592021009843	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
592021009844	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
592021009845	catalytic site [active]
592021009846	G-X2-G-X-G-K; other site
592021009847	hypothetical protein; Provisional; Region: PRK04323
592021009848	hypothetical protein; Provisional; Region: PRK11820
592021009849	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
592021009850	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
592021009851	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
592021009852	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
592021009853	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
592021009854	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
592021009855	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021009856	motif II; other site
592021009857	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
592021009858	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
592021009859	Domain of unknown function (DUF814); Region: DUF814; pfam05670
592021009860	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
592021009861	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
592021009862	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
592021009863	active site
592021009864	YoqO-like protein; Region: YoqO; pfam14037
592021009865	YoqO-like protein; Region: YoqO; pfam14037
592021009866	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
592021009867	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
592021009868	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021009869	active site
592021009870	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
592021009871	active site
592021009872	dimer interface [polypeptide binding]; other site
592021009873	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
592021009874	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
592021009875	heterodimer interface [polypeptide binding]; other site
592021009876	active site
592021009877	FMN binding site [chemical binding]; other site
592021009878	homodimer interface [polypeptide binding]; other site
592021009879	substrate binding site [chemical binding]; other site
592021009880	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
592021009881	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
592021009882	FAD binding pocket [chemical binding]; other site
592021009883	FAD binding motif [chemical binding]; other site
592021009884	phosphate binding motif [ion binding]; other site
592021009885	beta-alpha-beta structure motif; other site
592021009886	NAD binding pocket [chemical binding]; other site
592021009887	Iron coordination center [ion binding]; other site
592021009888	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
592021009889	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
592021009890	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
592021009891	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
592021009892	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
592021009893	ATP-grasp domain; Region: ATP-grasp_4; cl17255
592021009894	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
592021009895	IMP binding site; other site
592021009896	dimer interface [polypeptide binding]; other site
592021009897	interdomain contacts; other site
592021009898	partial ornithine binding site; other site
592021009899	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
592021009900	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
592021009901	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
592021009902	catalytic site [active]
592021009903	subunit interface [polypeptide binding]; other site
592021009904	dihydroorotase; Validated; Region: pyrC; PRK09357
592021009905	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
592021009906	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
592021009907	active site
592021009908	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
592021009909	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
592021009910	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
592021009911	uracil transporter; Provisional; Region: PRK10720
592021009912	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
592021009913	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021009914	active site
592021009915	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
592021009916	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021009917	RNA binding surface [nucleotide binding]; other site
592021009918	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
592021009919	active site
592021009920	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
592021009921	lipoprotein signal peptidase; Provisional; Region: PRK14787
592021009922	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
592021009923	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
592021009924	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
592021009925	active site
592021009926	HIGH motif; other site
592021009927	nucleotide binding site [chemical binding]; other site
592021009928	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
592021009929	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
592021009930	active site
592021009931	KMSKS motif; other site
592021009932	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
592021009933	tRNA binding surface [nucleotide binding]; other site
592021009934	anticodon binding site; other site
592021009935	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
592021009936	DivIVA protein; Region: DivIVA; pfam05103
592021009937	DivIVA domain; Region: DivI1A_domain; TIGR03544
592021009938	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
592021009939	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
592021009940	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021009941	RNA binding surface [nucleotide binding]; other site
592021009942	YGGT family; Region: YGGT; pfam02325
592021009943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
592021009944	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
592021009945	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
592021009946	catalytic residue [active]
592021009947	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
592021009948	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
592021009949	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
592021009950	sporulation sigma factor SigG; Reviewed; Region: PRK08215
592021009951	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021009952	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021009953	DNA binding residues [nucleotide binding]
592021009954	sporulation sigma factor SigE; Reviewed; Region: PRK08301
592021009955	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021009956	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021009957	DNA binding residues [nucleotide binding]
592021009958	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
592021009959	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
592021009960	cell division protein FtsZ; Validated; Region: PRK09330
592021009961	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
592021009962	nucleotide binding site [chemical binding]; other site
592021009963	SulA interaction site; other site
592021009964	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
592021009965	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
592021009966	nucleotide binding site [chemical binding]; other site
592021009967	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
592021009968	Cell division protein FtsA; Region: FtsA; pfam14450
592021009969	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
592021009970	Cell division protein FtsQ; Region: FtsQ; pfam03799
592021009971	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
592021009972	FAD binding domain; Region: FAD_binding_4; pfam01565
592021009973	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
592021009974	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
592021009975	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
592021009976	active site
592021009977	homodimer interface [polypeptide binding]; other site
592021009978	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
592021009979	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
592021009980	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
592021009981	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
592021009982	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
592021009983	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
592021009984	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
592021009985	Mg++ binding site [ion binding]; other site
592021009986	putative catalytic motif [active]
592021009987	putative substrate binding site [chemical binding]; other site
592021009988	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
592021009989	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
592021009990	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
592021009991	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
592021009992	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
592021009993	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021009994	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021009995	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
592021009996	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
592021009997	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021009998	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021009999	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
592021010000	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
592021010001	Cell division protein FtsL; Region: FtsL; cl11433
592021010002	MraW methylase family; Region: Methyltransf_5; pfam01795
592021010003	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
592021010004	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
592021010005	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
592021010006	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
592021010007	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
592021010008	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
592021010009	hypothetical protein; Provisional; Region: PRK13688
592021010010	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021010011	Coenzyme A binding pocket [chemical binding]; other site
592021010012	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
592021010013	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
592021010014	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
592021010015	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
592021010016	Replication-relaxation; Region: Replic_Relax; pfam13814
592021010017	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
592021010018	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021010019	non-specific DNA binding site [nucleotide binding]; other site
592021010020	salt bridge; other site
592021010021	sequence-specific DNA binding site [nucleotide binding]; other site
592021010022	hypothetical protein; Region: PHA02436
592021010023	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
592021010024	amidase catalytic site [active]
592021010025	Zn binding residues [ion binding]; other site
592021010026	substrate binding site [chemical binding]; other site
592021010027	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
592021010028	Holin family; Region: Phage_holin_4; pfam05105
592021010029	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
592021010030	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
592021010031	active site
592021010032	catalytic residues [active]
592021010033	DNA binding site [nucleotide binding]
592021010034	Int/Topo IB signature motif; other site
592021010035	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
592021010036	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
592021010037	putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633
592021010038	Phage tail protein; Region: Sipho_tail; cl17486
592021010039	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
592021010040	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
592021010041	phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725
592021010042	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
592021010043	oligomerization interface [polypeptide binding]; other site
592021010044	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
592021010045	Phage capsid family; Region: Phage_capsid; pfam05065
592021010046	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
592021010047	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
592021010048	oligomer interface [polypeptide binding]; other site
592021010049	active site residues [active]
592021010050	Phage-related protein [Function unknown]; Region: COG4695
592021010051	Phage portal protein; Region: Phage_portal; pfam04860
592021010052	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
592021010053	Phage terminase, small subunit; Region: Terminase_4; pfam05119
592021010054	HNH endonuclease; Region: HNH; pfam01844
592021010055	active site
592021010056	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
592021010057	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
592021010058	Int/Topo IB signature motif; other site
592021010059	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
592021010060	Protein of unknown function (DUF3983); Region: DUF3983; pfam13137
592021010061	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
592021010062	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
592021010063	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
592021010064	active site
592021010065	metal binding site [ion binding]; metal-binding site
592021010066	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
592021010067	trimer interface [polypeptide binding]; other site
592021010068	active site
592021010069	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
592021010070	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
592021010071	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021010072	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021010073	sequence-specific DNA binding site [nucleotide binding]; other site
592021010074	salt bridge; other site
592021010075	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
592021010076	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
592021010077	hypothetical protein; Validated; Region: PRK08116
592021010078	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021010079	Walker A motif; other site
592021010080	ATP binding site [chemical binding]; other site
592021010081	Helix-turn-helix domain; Region: HTH_36; pfam13730
592021010082	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
592021010083	Inositol polyphosphate kinase; Region: IPK; cl12283
592021010084	Helix-turn-helix domain; Region: HTH_17; pfam12728
592021010085	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021010086	non-specific DNA binding site [nucleotide binding]; other site
592021010087	salt bridge; other site
592021010088	sequence-specific DNA binding site [nucleotide binding]; other site
592021010089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021010090	non-specific DNA binding site [nucleotide binding]; other site
592021010091	salt bridge; other site
592021010092	sequence-specific DNA binding site [nucleotide binding]; other site
592021010093	V-type ATP synthase subunit I; Validated; Region: PRK05771
592021010094	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
592021010095	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
592021010096	Int/Topo IB signature motif; other site
592021010097	hypothetical protein; Provisional; Region: PRK13670
592021010098	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
592021010099	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
592021010100	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
592021010101	protein binding site [polypeptide binding]; other site
592021010102	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
592021010103	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
592021010104	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
592021010105	active site
592021010106	nucleophile elbow; other site
592021010107	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
592021010108	Nucleoside recognition; Region: Gate; pfam07670
592021010109	Nucleoside recognition; Region: Gate; pfam07670
592021010110	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
592021010111	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
592021010112	active site
592021010113	(T/H)XGH motif; other site
592021010114	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
592021010115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021010116	S-adenosylmethionine binding site [chemical binding]; other site
592021010117	ylbH leader
592021010118	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
592021010119	Protein of unknown function (DUF964); Region: DUF964; pfam06133
592021010120	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
592021010121	catalytic core [active]
592021010122	YlbE-like protein; Region: YlbE; pfam14003
592021010123	Putative coat protein; Region: YlbD_coat; pfam14071
592021010124	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
592021010125	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
592021010126	YugN-like family; Region: YugN; pfam08868
592021010127	formamidase; Provisional; Region: amiF; PRK13287
592021010128	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
592021010129	multimer interface [polypeptide binding]; other site
592021010130	active site
592021010131	catalytic triad [active]
592021010132	dimer interface [polypeptide binding]; other site
592021010133	cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737
592021010134	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
592021010135	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
592021010136	Subunit I/III interface [polypeptide binding]; other site
592021010137	Subunit III/IV interface [polypeptide binding]; other site
592021010138	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
592021010139	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
592021010140	D-pathway; other site
592021010141	Putative ubiquinol binding site [chemical binding]; other site
592021010142	Low-spin heme (heme b) binding site [chemical binding]; other site
592021010143	Putative water exit pathway; other site
592021010144	Binuclear center (heme o3/CuB) [ion binding]; other site
592021010145	K-pathway; other site
592021010146	Putative proton exit pathway; other site
592021010147	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
592021010148	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
592021010149	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
592021010150	Cytochrome c; Region: Cytochrom_C; pfam00034
592021010151	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
592021010152	UbiA prenyltransferase family; Region: UbiA; pfam01040
592021010153	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
592021010154	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
592021010155	pyruvate carboxylase; Reviewed; Region: PRK12999
592021010156	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
592021010157	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
592021010158	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
592021010159	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
592021010160	active site
592021010161	catalytic residues [active]
592021010162	metal binding site [ion binding]; metal-binding site
592021010163	homodimer binding site [polypeptide binding]; other site
592021010164	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
592021010165	carboxyltransferase (CT) interaction site; other site
592021010166	biotinylation site [posttranslational modification]; other site
592021010167	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
592021010168	hypothetical protein; Provisional; Region: PRK13666
592021010169	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
592021010170	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
592021010171	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
592021010172	putative active site [active]
592021010173	PhoH-like protein; Region: PhoH; pfam02562
592021010174	hypothetical protein; Provisional; Region: PRK06733
592021010175	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
592021010176	YlaH-like protein; Region: YlaH; pfam14036
592021010177	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
592021010178	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
592021010179	G1 box; other site
592021010180	putative GEF interaction site [polypeptide binding]; other site
592021010181	GTP/Mg2+ binding site [chemical binding]; other site
592021010182	Switch I region; other site
592021010183	G2 box; other site
592021010184	G3 box; other site
592021010185	Switch II region; other site
592021010186	G4 box; other site
592021010187	G5 box; other site
592021010188	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
592021010189	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
592021010190	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
592021010191	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
592021010192	active site
592021010193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
592021010194	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
592021010195	hypothetical protein; Provisional; Region: PRK04387
592021010196	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
592021010197	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
592021010198	homodimer interface [polypeptide binding]; other site
592021010199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021010200	catalytic residue [active]
592021010201	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
592021010202	transglutaminase; Provisional; Region: tgl; PRK03187
592021010203	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
592021010204	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
592021010205	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
592021010206	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
592021010207	Domain of unknown function (DUF1885); Region: DUF1885; pfam08968
592021010208	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
592021010209	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021010210	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
592021010211	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
592021010212	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
592021010213	E3 interaction surface; other site
592021010214	lipoyl attachment site [posttranslational modification]; other site
592021010215	e3 binding domain; Region: E3_binding; pfam02817
592021010216	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
592021010217	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
592021010218	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
592021010219	alpha subunit interface [polypeptide binding]; other site
592021010220	TPP binding site [chemical binding]; other site
592021010221	heterodimer interface [polypeptide binding]; other site
592021010222	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
592021010223	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
592021010224	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
592021010225	TPP-binding site [chemical binding]; other site
592021010226	heterodimer interface [polypeptide binding]; other site
592021010227	tetramer interface [polypeptide binding]; other site
592021010228	phosphorylation loop region [posttranslational modification]
592021010229	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
592021010230	active site
592021010231	catalytic residues [active]
592021010232	metal binding site [ion binding]; metal-binding site
592021010233	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021010234	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021010235	active site
592021010236	motif I; other site
592021010237	motif II; other site
592021010238	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021010239	hypothetical protein; Provisional; Region: PRK13667
592021010240	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
592021010241	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021010242	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
592021010243	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
592021010244	TrkA-N domain; Region: TrkA_N; pfam02254
592021010245	TrkA-C domain; Region: TrkA_C; pfam02080
592021010246	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
592021010247	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
592021010248	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
592021010249	metal binding site [ion binding]; metal-binding site
592021010250	putative dimer interface [polypeptide binding]; other site
592021010251	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
592021010252	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
592021010253	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
592021010254	trimer interface [polypeptide binding]; other site
592021010255	active site
592021010256	substrate binding site [chemical binding]; other site
592021010257	CoA binding site [chemical binding]; other site
592021010258	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021010259	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021010260	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021010261	dimerization interface [polypeptide binding]; other site
592021010262	FOG: CBS domain [General function prediction only]; Region: COG0517
592021010263	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
592021010264	Antirepressor AbbA; Region: AbbA_antirepres; pfam14156
592021010265	Protein of unknown function (DUF458); Region: DUF458; pfam04308
592021010266	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
592021010267	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
592021010268	catalytic residues [active]
592021010269	Protein of unknown function (DUF3993); Region: DUF3993; pfam13158
592021010270	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
592021010271	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
592021010272	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
592021010273	short chain dehydrogenase; Provisional; Region: PRK07677
592021010274	NAD(P) binding site [chemical binding]; other site
592021010275	substrate binding site [chemical binding]; other site
592021010276	homotetramer interface [polypeptide binding]; other site
592021010277	active site
592021010278	homodimer interface [polypeptide binding]; other site
592021010279	phosphodiesterase YaeI; Provisional; Region: PRK11340
592021010280	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
592021010281	putative active site [active]
592021010282	putative metal binding site [ion binding]; other site
592021010283	polyphosphate kinase; Provisional; Region: PRK05443
592021010284	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
592021010285	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
592021010286	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
592021010287	putative domain interface [polypeptide binding]; other site
592021010288	putative active site [active]
592021010289	catalytic site [active]
592021010290	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
592021010291	putative domain interface [polypeptide binding]; other site
592021010292	putative active site [active]
592021010293	catalytic site [active]
592021010294	exopolyphosphatase; Region: exo_poly_only; TIGR03706
592021010295	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
592021010296	nucleotide binding site [chemical binding]; other site
592021010297	YkyB-like protein; Region: YkyB; pfam14177
592021010298	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
592021010299	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021010300	I-site; other site
592021010301	active site
592021010302	metal binding site [ion binding]; metal-binding site
592021010303	Phage lysis protein, holin; Region: Phage_holin; cl04675
592021010304	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021010305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021010306	putative substrate translocation pore; other site
592021010307	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021010308	Transcriptional regulator PadR-like family; Region: PadR; cl17335
592021010309	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
592021010310	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
592021010311	THF binding site; other site
592021010312	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
592021010313	substrate binding site [chemical binding]; other site
592021010314	THF binding site; other site
592021010315	zinc-binding site [ion binding]; other site
592021010316	Competence protein J (ComJ); Region: ComJ; pfam11033
592021010317	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
592021010318	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
592021010319	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021010320	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021010321	dimer interface [polypeptide binding]; other site
592021010322	phosphorylation site [posttranslational modification]
592021010323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021010324	ATP binding site [chemical binding]; other site
592021010325	Mg2+ binding site [ion binding]; other site
592021010326	G-X-G motif; other site
592021010327	aminotransferase A; Validated; Region: PRK07683
592021010328	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021010329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021010330	homodimer interface [polypeptide binding]; other site
592021010331	catalytic residue [active]
592021010332	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021010333	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021010334	DNA binding site [nucleotide binding]
592021010335	domain linker motif; other site
592021010336	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
592021010337	putative dimerization interface [polypeptide binding]; other site
592021010338	putative ligand binding site [chemical binding]; other site
592021010339	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
592021010340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021010341	dimer interface [polypeptide binding]; other site
592021010342	conserved gate region; other site
592021010343	putative PBP binding loops; other site
592021010344	ABC-ATPase subunit interface; other site
592021010345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021010346	dimer interface [polypeptide binding]; other site
592021010347	conserved gate region; other site
592021010348	putative PBP binding loops; other site
592021010349	ABC-ATPase subunit interface; other site
592021010350	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
592021010351	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
592021010352	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
592021010353	homodimer interface [polypeptide binding]; other site
592021010354	maltodextrin glucosidase; Provisional; Region: PRK10785
592021010355	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
592021010356	active site
592021010357	homodimer interface [polypeptide binding]; other site
592021010358	catalytic site [active]
592021010359	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
592021010360	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
592021010361	Ca binding site [ion binding]; other site
592021010362	active site
592021010363	catalytic site [active]
592021010364	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
592021010365	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
592021010366	Walker A/P-loop; other site
592021010367	ATP binding site [chemical binding]; other site
592021010368	Q-loop/lid; other site
592021010369	ABC transporter signature motif; other site
592021010370	Walker B; other site
592021010371	D-loop; other site
592021010372	H-loop/switch region; other site
592021010373	TOBE domain; Region: TOBE_2; pfam08402
592021010374	hypothetical protein; Provisional; Region: PRK06720
592021010375	NAD(P) binding site [chemical binding]; other site
592021010376	RDD family; Region: RDD; pfam06271
592021010377	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
592021010378	Protein of unknown function (DUF3997); Region: DUF3997; pfam13162
592021010379	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
592021010380	Predicted ATPase [General function prediction only]; Region: COG3910
592021010381	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021010382	Walker A/P-loop; other site
592021010383	ATP binding site [chemical binding]; other site
592021010384	Q-loop/lid; other site
592021010385	ABC transporter signature motif; other site
592021010386	Walker B; other site
592021010387	D-loop; other site
592021010388	H-loop/switch region; other site
592021010389	putative acyltransferase; Provisional; Region: PRK05790
592021010390	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
592021010391	dimer interface [polypeptide binding]; other site
592021010392	active site
592021010393	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
592021010394	nudix motif; other site
592021010395	Protein of unknown function (DUF3928); Region: DUF3928; pfam13065
592021010396	hypothetical protein; Validated; Region: PRK07668
592021010397	hypothetical protein; Validated; Region: PRK07668
592021010398	hypothetical protein; Validated; Region: PRK07668
592021010399	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021010400	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
592021010401	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
592021010402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
592021010403	NAD(P) binding site [chemical binding]; other site
592021010404	active site
592021010405	YvrJ protein family; Region: YvrJ; pfam12841
592021010406	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
592021010407	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
592021010408	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
592021010409	Phosphotransferase enzyme family; Region: APH; pfam01636
592021010410	Predicted amidohydrolase [General function prediction only]; Region: COG0388
592021010411	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
592021010412	putative active site [active]
592021010413	catalytic triad [active]
592021010414	putative dimer interface [polypeptide binding]; other site
592021010415	transaminase; Reviewed; Region: PRK08068
592021010416	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021010417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021010418	homodimer interface [polypeptide binding]; other site
592021010419	catalytic residue [active]
592021010420	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
592021010421	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
592021010422	dimer interface [polypeptide binding]; other site
592021010423	active site
592021010424	catalytic residue [active]
592021010425	metal binding site [ion binding]; metal-binding site
592021010426	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552
592021010427	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
592021010428	methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754
592021010429	intersubunit interface [polypeptide binding]; other site
592021010430	active site
592021010431	Zn2+ binding site [ion binding]; other site
592021010432	ARD/ARD' family; Region: ARD; pfam03079
592021010433	Cupin domain; Region: Cupin_2; pfam07883
592021010434	Protein of unknown function (DUF3909); Region: DUF3909; pfam13077
592021010435	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
592021010436	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021010437	metal binding site [ion binding]; metal-binding site
592021010438	active site
592021010439	I-site; other site
592021010440	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
592021010441	dimer interface [polypeptide binding]; other site
592021010442	FMN binding site [chemical binding]; other site
592021010443	Protein of unknown function (DUF3915); Region: DUF3915; pfam13054
592021010444	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
592021010445	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
592021010446	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
592021010447	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
592021010448	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
592021010449	dimerization domain swap beta strand [polypeptide binding]; other site
592021010450	regulatory protein interface [polypeptide binding]; other site
592021010451	active site
592021010452	regulatory phosphorylation site [posttranslational modification]; other site
592021010453	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
592021010454	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
592021010455	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
592021010456	active site turn [active]
592021010457	phosphorylation site [posttranslational modification]
592021010458	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
592021010459	HPr interaction site; other site
592021010460	glycerol kinase (GK) interaction site [polypeptide binding]; other site
592021010461	active site
592021010462	phosphorylation site [posttranslational modification]
592021010463	transcriptional antiterminator BglG; Provisional; Region: PRK09772
592021010464	CAT RNA binding domain; Region: CAT_RBD; smart01061
592021010465	PRD domain; Region: PRD; pfam00874
592021010466	PRD domain; Region: PRD; pfam00874
592021010467	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021010468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021010469	active site
592021010470	motif I; other site
592021010471	motif II; other site
592021010472	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021010473	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
592021010474	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
592021010475	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
592021010476	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
592021010477	active site
592021010478	trimer interface [polypeptide binding]; other site
592021010479	allosteric site; other site
592021010480	active site lid [active]
592021010481	hexamer (dimer of trimers) interface [polypeptide binding]; other site
592021010482	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
592021010483	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
592021010484	active site
592021010485	dimer interface [polypeptide binding]; other site
592021010486	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
592021010487	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021010488	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
592021010489	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
592021010490	Domain of unknown function (DUF309); Region: DUF309; pfam03745
592021010491	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021010492	Coenzyme A binding pocket [chemical binding]; other site
592021010493	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
592021010494	active site
592021010495	Predicted secreted protein [Function unknown]; Region: COG4086
592021010496	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
592021010497	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021010498	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
592021010499	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
592021010500	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
592021010501	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
592021010502	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
592021010503	stage V sporulation protein AD; Validated; Region: PRK08304
592021010504	stage V sporulation protein AD; Provisional; Region: PRK12404
592021010505	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
592021010506	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
592021010507	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
592021010508	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
592021010509	Na2 binding site [ion binding]; other site
592021010510	putative substrate binding site 1 [chemical binding]; other site
592021010511	Na binding site 1 [ion binding]; other site
592021010512	putative substrate binding site 2 [chemical binding]; other site
592021010513	sporulation sigma factor SigF; Validated; Region: PRK05572
592021010514	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021010515	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
592021010516	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021010517	DNA binding residues [nucleotide binding]
592021010518	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
592021010519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021010520	ATP binding site [chemical binding]; other site
592021010521	Mg2+ binding site [ion binding]; other site
592021010522	G-X-G motif; other site
592021010523	anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886
592021010524	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
592021010525	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021010526	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
592021010527	Predicted transcriptional regulators [Transcription]; Region: COG1725
592021010528	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021010529	DNA-binding site [nucleotide binding]; DNA binding site
592021010530	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021010531	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021010532	Walker A/P-loop; other site
592021010533	ATP binding site [chemical binding]; other site
592021010534	Q-loop/lid; other site
592021010535	ABC transporter signature motif; other site
592021010536	Walker B; other site
592021010537	D-loop; other site
592021010538	H-loop/switch region; other site
592021010539	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
592021010540	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021010541	MarR family; Region: MarR; pfam01047
592021010542	MarR family; Region: MarR_2; cl17246
592021010543	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
592021010544	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
592021010545	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
592021010546	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
592021010547	oligomer interface [polypeptide binding]; other site
592021010548	metal binding site [ion binding]; metal-binding site
592021010549	metal binding site [ion binding]; metal-binding site
592021010550	putative Cl binding site [ion binding]; other site
592021010551	aspartate ring; other site
592021010552	basic sphincter; other site
592021010553	hydrophobic gate; other site
592021010554	periplasmic entrance; other site
592021010555	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
592021010556	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
592021010557	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
592021010558	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
592021010559	purine nucleoside phosphorylase; Provisional; Region: PRK08202
592021010560	phosphopentomutase; Provisional; Region: PRK05362
592021010561	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
592021010562	YtkA-like; Region: YtkA; pfam13115
592021010563	YtkA-like; Region: YtkA; pfam13115
592021010564	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
592021010565	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
592021010566	active site
592021010567	Int/Topo IB signature motif; other site
592021010568	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
592021010569	ferric uptake regulator; Provisional; Region: fur; PRK09462
592021010570	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
592021010571	metal binding site 2 [ion binding]; metal-binding site
592021010572	putative DNA binding helix; other site
592021010573	metal binding site 1 [ion binding]; metal-binding site
592021010574	dimer interface [polypeptide binding]; other site
592021010575	structural Zn2+ binding site [ion binding]; other site
592021010576	stage II sporulation protein M; Region: spo_II_M; TIGR02831
592021010577	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021010578	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021010579	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
592021010580	dimer interface [polypeptide binding]; other site
592021010581	ADP-ribose binding site [chemical binding]; other site
592021010582	active site
592021010583	nudix motif; other site
592021010584	metal binding site [ion binding]; metal-binding site
592021010585	Protein of unknown function (DUF3936); Region: DUF3936; pfam13072
592021010586	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021010587	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021010588	active site
592021010589	catalytic tetrad [active]
592021010590	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021010591	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021010592	active site
592021010593	catalytic tetrad [active]
592021010594	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
592021010595	Protein of unknown function (DUF3886); Region: DUF3886; pfam13025
592021010596	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
592021010597	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
592021010598	putative active site [active]
592021010599	putative metal binding site [ion binding]; other site
592021010600	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
592021010601	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
592021010602	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
592021010603	Predicted permease [General function prediction only]; Region: COG2056
592021010604	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
592021010605	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
592021010606	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021010607	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021010608	DNA binding site [nucleotide binding]
592021010609	domain linker motif; other site
592021010610	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
592021010611	dimerization interface [polypeptide binding]; other site
592021010612	ligand binding site [chemical binding]; other site
592021010613	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
592021010614	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021010615	Coenzyme A binding pocket [chemical binding]; other site
592021010616	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
592021010617	Protein of unknown function (DUF2552); Region: DUF2552; pfam10827
592021010618	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
592021010619	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
592021010620	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
592021010621	catalytic motif [active]
592021010622	Zn binding site [ion binding]; other site
592021010623	RibD C-terminal domain; Region: RibD_C; cl17279
592021010624	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
592021010625	Lumazine binding domain; Region: Lum_binding; pfam00677
592021010626	Lumazine binding domain; Region: Lum_binding; pfam00677
592021010627	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
592021010628	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
592021010629	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
592021010630	dimerization interface [polypeptide binding]; other site
592021010631	active site
592021010632	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
592021010633	homopentamer interface [polypeptide binding]; other site
592021010634	active site
592021010635	biotin synthase; Validated; Region: PRK06256
592021010636	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021010637	FeS/SAM binding site; other site
592021010638	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
592021010639	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
592021010640	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021010641	S-adenosylmethionine binding site [chemical binding]; other site
592021010642	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021010643	TAP-like protein; Region: Abhydrolase_4; pfam08386
592021010644	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
592021010645	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
592021010646	substrate-cofactor binding pocket; other site
592021010647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021010648	catalytic residue [active]
592021010649	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
592021010650	AAA domain; Region: AAA_26; pfam13500
592021010651	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
592021010652	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021010653	inhibitor-cofactor binding pocket; inhibition site
592021010654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021010655	catalytic residue [active]
592021010656	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
592021010657	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418
592021010658	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
592021010659	active site
592021010660	metal binding site [ion binding]; metal-binding site
592021010661	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
592021010662	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
592021010663	active site
592021010664	catalytic triad [active]
592021010665	oxyanion hole [active]
592021010666	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021010667	dimerization interface [polypeptide binding]; other site
592021010668	putative DNA binding site [nucleotide binding]; other site
592021010669	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021010670	putative Zn2+ binding site [ion binding]; other site
592021010671	ornithine carbamoyltransferase; Provisional; Region: PRK00779
592021010672	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
592021010673	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
592021010674	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
592021010675	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021010676	inhibitor-cofactor binding pocket; inhibition site
592021010677	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021010678	catalytic residue [active]
592021010679	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
592021010680	nucleotide binding site [chemical binding]; other site
592021010681	N-acetyl-L-glutamate binding site [chemical binding]; other site
592021010682	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
592021010683	heterotetramer interface [polypeptide binding]; other site
592021010684	active site pocket [active]
592021010685	cleavage site
592021010686	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
592021010687	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
592021010688	YqzH-like protein; Region: YqzH; pfam14164
592021010689	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
592021010690	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
592021010691	NAD(P) binding site [chemical binding]; other site
592021010692	active site
592021010693	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679
592021010694	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
592021010695	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
592021010696	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
592021010697	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
592021010698	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
592021010699	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
592021010700	putative L-serine binding site [chemical binding]; other site
592021010701	ribonuclease Z; Region: RNase_Z; TIGR02651
592021010702	Protein of unknown function (DUF3932); Region: DUF3932; pfam13068
592021010703	DNA polymerase IV; Validated; Region: PRK01810
592021010704	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
592021010705	active site
592021010706	DNA binding site [nucleotide binding]
592021010707	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
592021010708	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
592021010709	peptidase T-like protein; Region: PepT-like; TIGR01883
592021010710	metal binding site [ion binding]; metal-binding site
592021010711	putative dimer interface [polypeptide binding]; other site
592021010712	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021010713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021010714	Protein of unknown function (DUF3894); Region: DUF3894; pfam13033
592021010715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
592021010716	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
592021010717	Predicted membrane protein [Function unknown]; Region: COG4129
592021010718	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
592021010719	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
592021010720	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
592021010721	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
592021010722	Walker A/P-loop; other site
592021010723	ATP binding site [chemical binding]; other site
592021010724	Q-loop/lid; other site
592021010725	ABC transporter signature motif; other site
592021010726	Walker B; other site
592021010727	D-loop; other site
592021010728	H-loop/switch region; other site
592021010729	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
592021010730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021010731	dimer interface [polypeptide binding]; other site
592021010732	conserved gate region; other site
592021010733	putative PBP binding loops; other site
592021010734	ABC-ATPase subunit interface; other site
592021010735	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
592021010736	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
592021010737	substrate binding pocket [chemical binding]; other site
592021010738	membrane-bound complex binding site; other site
592021010739	hinge residues; other site
592021010740	Disulphide isomerase; Region: Disulph_isomer; pfam06491
592021010741	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
592021010742	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
592021010743	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
592021010744	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
592021010745	E3 interaction surface; other site
592021010746	lipoyl attachment site [posttranslational modification]; other site
592021010747	e3 binding domain; Region: E3_binding; pfam02817
592021010748	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
592021010749	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
592021010750	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
592021010751	alpha subunit interface [polypeptide binding]; other site
592021010752	TPP binding site [chemical binding]; other site
592021010753	heterodimer interface [polypeptide binding]; other site
592021010754	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
592021010755	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
592021010756	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
592021010757	tetramer interface [polypeptide binding]; other site
592021010758	TPP-binding site [chemical binding]; other site
592021010759	heterodimer interface [polypeptide binding]; other site
592021010760	phosphorylation loop region [posttranslational modification]
592021010761	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
592021010762	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
592021010763	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021010764	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
592021010765	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
592021010766	nucleotide binding site [chemical binding]; other site
592021010767	Acetokinase family; Region: Acetate_kinase; cl17229
592021010768	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
592021010769	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
592021010770	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
592021010771	NAD binding site [chemical binding]; other site
592021010772	Phe binding site; other site
592021010773	phosphate butyryltransferase; Validated; Region: PRK07742
592021010774	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
592021010775	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021010776	putative active site [active]
592021010777	heme pocket [chemical binding]; other site
592021010778	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021010779	putative active site [active]
592021010780	heme pocket [chemical binding]; other site
592021010781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021010782	Walker A motif; other site
592021010783	ATP binding site [chemical binding]; other site
592021010784	Walker B motif; other site
592021010785	arginine finger; other site
592021010786	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
592021010787	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
592021010788	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
592021010789	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
592021010790	active site
592021010791	catalytic site [active]
592021010792	metal binding site [ion binding]; metal-binding site
592021010793	dimer interface [polypeptide binding]; other site
592021010794	YycC-like protein; Region: YycC; pfam14174
592021010795	conserved hypothetical integral membrane protein; Region: TIGR03766
592021010796	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
592021010797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021010798	active site
592021010799	phosphorylation site [posttranslational modification]
592021010800	intermolecular recognition site; other site
592021010801	dimerization interface [polypeptide binding]; other site
592021010802	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
592021010803	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
592021010804	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
592021010805	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
592021010806	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
592021010807	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
592021010808	Walker A/P-loop; other site
592021010809	ATP binding site [chemical binding]; other site
592021010810	Q-loop/lid; other site
592021010811	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
592021010812	ABC transporter signature motif; other site
592021010813	Walker B; other site
592021010814	D-loop; other site
592021010815	H-loop/switch region; other site
592021010816	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
592021010817	arginine repressor; Provisional; Region: PRK04280
592021010818	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
592021010819	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
592021010820	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021010821	RNA binding surface [nucleotide binding]; other site
592021010822	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
592021010823	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
592021010824	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
592021010825	TPP-binding site; other site
592021010826	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
592021010827	PYR/PP interface [polypeptide binding]; other site
592021010828	dimer interface [polypeptide binding]; other site
592021010829	TPP binding site [chemical binding]; other site
592021010830	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
592021010831	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
592021010832	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
592021010833	substrate binding pocket [chemical binding]; other site
592021010834	chain length determination region; other site
592021010835	substrate-Mg2+ binding site; other site
592021010836	catalytic residues [active]
592021010837	aspartate-rich region 1; other site
592021010838	active site lid residues [active]
592021010839	aspartate-rich region 2; other site
592021010840	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063
592021010841	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
592021010842	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
592021010843	generic binding surface II; other site
592021010844	generic binding surface I; other site
592021010845	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
592021010846	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
592021010847	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
592021010848	homodimer interface [polypeptide binding]; other site
592021010849	NADP binding site [chemical binding]; other site
592021010850	substrate binding site [chemical binding]; other site
592021010851	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
592021010852	putative RNA binding site [nucleotide binding]; other site
592021010853	Asp23 family; Region: Asp23; pfam03780
592021010854	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
592021010855	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
592021010856	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
592021010857	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
592021010858	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
592021010859	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
592021010860	carboxyltransferase (CT) interaction site; other site
592021010861	biotinylation site [posttranslational modification]; other site
592021010862	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
592021010863	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
592021010864	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
592021010865	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
592021010866	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
592021010867	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
592021010868	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
592021010869	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
592021010870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021010871	Walker A motif; other site
592021010872	ATP binding site [chemical binding]; other site
592021010873	Walker B motif; other site
592021010874	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
592021010875	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021010876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021010877	elongation factor P; Validated; Region: PRK00529
592021010878	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
592021010879	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
592021010880	RNA binding site [nucleotide binding]; other site
592021010881	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
592021010882	RNA binding site [nucleotide binding]; other site
592021010883	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
592021010884	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
592021010885	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
592021010886	active site
592021010887	Dehydroquinase class II; Region: DHquinase_II; pfam01220
592021010888	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
592021010889	trimer interface [polypeptide binding]; other site
592021010890	active site
592021010891	dimer interface [polypeptide binding]; other site
592021010892	Conserved membrane protein YqhR; Region: YqhR; pfam11085
592021010893	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
592021010894	CCC1-related family of proteins; Region: CCC1_like; cl00278
592021010895	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
592021010896	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
592021010897	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021010898	motif II; other site
592021010899	manganese transport transcriptional regulator; Provisional; Region: PRK03902
592021010900	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
592021010901	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
592021010902	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
592021010903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021010904	FeS/SAM binding site; other site
592021010905	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
592021010906	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
592021010907	active site residue [active]
592021010908	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021010909	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021010910	DNA binding site [nucleotide binding]
592021010911	domain linker motif; other site
592021010912	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
592021010913	putative dimerization interface [polypeptide binding]; other site
592021010914	putative ligand binding site [chemical binding]; other site
592021010915	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021010916	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021010917	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
592021010918	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
592021010919	Protein of unknown function (DUF3975); Region: DUF3975; pfam13126
592021010920	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
592021010921	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
592021010922	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
592021010923	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021010924	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021010925	Walker A/P-loop; other site
592021010926	ATP binding site [chemical binding]; other site
592021010927	Q-loop/lid; other site
592021010928	ABC transporter signature motif; other site
592021010929	Walker B; other site
592021010930	D-loop; other site
592021010931	H-loop/switch region; other site
592021010932	Predicted transcriptional regulators [Transcription]; Region: COG1725
592021010933	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021010934	DNA-binding site [nucleotide binding]; DNA binding site
592021010935	Protein of unknown function (DUF3929); Region: DUF3929; pfam13066
592021010936	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
592021010937	tetramer interface [polypeptide binding]; other site
592021010938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021010939	catalytic residue [active]
592021010940	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
592021010941	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
592021010942	tetramer interface [polypeptide binding]; other site
592021010943	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021010944	catalytic residue [active]
592021010945	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
592021010946	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
592021010947	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
592021010948	DEAD-like helicases superfamily; Region: DEXDc; smart00487
592021010949	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021010950	ATP binding site [chemical binding]; other site
592021010951	putative Mg++ binding site [ion binding]; other site
592021010952	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021010953	nucleotide binding region [chemical binding]; other site
592021010954	ATP-binding site [chemical binding]; other site
592021010955	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
592021010956	YqzE-like protein; Region: YqzE; pfam14038
592021010957	shikimate kinase; Reviewed; Region: aroK; PRK00131
592021010958	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
592021010959	ADP binding site [chemical binding]; other site
592021010960	magnesium binding site [ion binding]; other site
592021010961	putative shikimate binding site; other site
592021010962	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
592021010963	dihydroorotase; Provisional; Region: PRK04250
592021010964	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
592021010965	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
592021010966	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
592021010967	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
592021010968	Type II/IV secretion system protein; Region: T2SE; pfam00437
592021010969	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
592021010970	Walker A motif; other site
592021010971	ATP binding site [chemical binding]; other site
592021010972	Walker B motif; other site
592021010973	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021010974	putative DNA binding site [nucleotide binding]; other site
592021010975	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
592021010976	putative Zn2+ binding site [ion binding]; other site
592021010977	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
592021010978	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
592021010979	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
592021010980	Protein of unknown function (DUF3912); Region: DUF3912; pfam13051
592021010981	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
592021010982	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
592021010983	Protein of unknown function (DUF3966); Region: DUF3966; pfam13110
592021010984	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
592021010985	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
592021010986	active site
592021010987	homodimer interface [polypeptide binding]; other site
592021010988	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
592021010989	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
592021010990	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
592021010991	substrate binding pocket [chemical binding]; other site
592021010992	dimer interface [polypeptide binding]; other site
592021010993	inhibitor binding site; inhibition site
592021010994	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
592021010995	B12 binding site [chemical binding]; other site
592021010996	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
592021010997	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
592021010998	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
592021010999	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
592021011000	FAD binding site [chemical binding]; other site
592021011001	cystathionine gamma-synthase; Reviewed; Region: PRK08247
592021011002	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
592021011003	homodimer interface [polypeptide binding]; other site
592021011004	substrate-cofactor binding pocket; other site
592021011005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021011006	catalytic residue [active]
592021011007	cystathionine beta-lyase; Provisional; Region: PRK08064
592021011008	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
592021011009	homodimer interface [polypeptide binding]; other site
592021011010	substrate-cofactor binding pocket; other site
592021011011	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021011012	catalytic residue [active]
592021011013	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021011014	dimerization interface [polypeptide binding]; other site
592021011015	putative DNA binding site [nucleotide binding]; other site
592021011016	putative Zn2+ binding site [ion binding]; other site
592021011017	Uncharacterized conserved protein [Function unknown]; Region: COG1565
592021011018	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
592021011019	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
592021011020	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
592021011021	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
592021011022	nucleotide binding site [chemical binding]; other site
592021011023	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
592021011024	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
592021011025	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
592021011026	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
592021011027	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
592021011028	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
592021011029	active site
592021011030	Substrate binding site; other site
592021011031	Mg++ binding site; other site
592021011032	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
592021011033	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
592021011034	active site
592021011035	metal binding site [ion binding]; metal-binding site
592021011036	substrate binding site [chemical binding]; other site
592021011037	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
592021011038	PhoU domain; Region: PhoU; pfam01895
592021011039	PhoU domain; Region: PhoU; pfam01895
592021011040	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
592021011041	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
592021011042	Walker A/P-loop; other site
592021011043	ATP binding site [chemical binding]; other site
592021011044	Q-loop/lid; other site
592021011045	ABC transporter signature motif; other site
592021011046	Walker B; other site
592021011047	D-loop; other site
592021011048	H-loop/switch region; other site
592021011049	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
592021011050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021011051	dimer interface [polypeptide binding]; other site
592021011052	conserved gate region; other site
592021011053	putative PBP binding loops; other site
592021011054	ABC-ATPase subunit interface; other site
592021011055	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
592021011056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021011057	dimer interface [polypeptide binding]; other site
592021011058	conserved gate region; other site
592021011059	putative PBP binding loops; other site
592021011060	ABC-ATPase subunit interface; other site
592021011061	PBP superfamily domain; Region: PBP_like_2; cl17296
592021011062	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
592021011063	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021011064	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021011065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021011066	putative substrate translocation pore; other site
592021011067	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021011068	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
592021011069	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
592021011070	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
592021011071	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
592021011072	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
592021011073	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
592021011074	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
592021011075	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
592021011076	metal binding site 2 [ion binding]; metal-binding site
592021011077	putative DNA binding helix; other site
592021011078	metal binding site 1 [ion binding]; metal-binding site
592021011079	dimer interface [polypeptide binding]; other site
592021011080	structural Zn2+ binding site [ion binding]; other site
592021011081	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
592021011082	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021011083	ABC-ATPase subunit  interface; other site
592021011084	dimer interface [polypeptide binding]; other site
592021011085	putative PBP binding regions; other site
592021011086	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
592021011087	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
592021011088	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021011089	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021011090	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021011091	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
592021011092	endonuclease IV; Provisional; Region: PRK01060
592021011093	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
592021011094	AP (apurinic/apyrimidinic) site pocket; other site
592021011095	DNA interaction; other site
592021011096	Metal-binding active site; metal-binding site
592021011097	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
592021011098	DEAD-like helicases superfamily; Region: DEXDc; smart00487
592021011099	ATP binding site [chemical binding]; other site
592021011100	Mg++ binding site [ion binding]; other site
592021011101	motif III; other site
592021011102	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021011103	nucleotide binding region [chemical binding]; other site
592021011104	ATP-binding site [chemical binding]; other site
592021011105	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
592021011106	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
592021011107	Uncharacterized conserved protein [Function unknown]; Region: COG0327
592021011108	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
592021011109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
592021011110	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
592021011111	Uncharacterized conserved protein [Function unknown]; Region: COG0327
592021011112	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
592021011113	Family of unknown function (DUF633); Region: DUF633; pfam04816
592021011114	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
592021011115	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
592021011116	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
592021011117	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
592021011118	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
592021011119	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021011120	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
592021011121	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021011122	DNA binding residues [nucleotide binding]
592021011123	DNA primase; Validated; Region: dnaG; PRK05667
592021011124	CHC2 zinc finger; Region: zf-CHC2; pfam01807
592021011125	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
592021011126	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
592021011127	active site
592021011128	metal binding site [ion binding]; metal-binding site
592021011129	interdomain interaction site; other site
592021011130	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
592021011131	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
592021011132	PEP synthetase regulatory protein; Provisional; Region: PRK05339
592021011133	HTH domain; Region: HTH_11; pfam08279
592021011134	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
592021011135	FOG: CBS domain [General function prediction only]; Region: COG0517
592021011136	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
592021011137	Recombination protein O N terminal; Region: RecO_N; pfam11967
592021011138	Recombination protein O C terminal; Region: RecO_C; pfam02565
592021011139	YqzL-like protein; Region: YqzL; pfam14006
592021011140	GTPase Era; Reviewed; Region: era; PRK00089
592021011141	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
592021011142	G1 box; other site
592021011143	GTP/Mg2+ binding site [chemical binding]; other site
592021011144	Switch I region; other site
592021011145	G2 box; other site
592021011146	Switch II region; other site
592021011147	G3 box; other site
592021011148	G4 box; other site
592021011149	G5 box; other site
592021011150	KH domain; Region: KH_2; pfam07650
592021011151	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
592021011152	active site
592021011153	catalytic motif [active]
592021011154	Zn binding site [ion binding]; other site
592021011155	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
592021011156	metal-binding heat shock protein; Provisional; Region: PRK00016
592021011157	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
592021011158	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
592021011159	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021011160	Zn2+ binding site [ion binding]; other site
592021011161	Mg2+ binding site [ion binding]; other site
592021011162	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
592021011163	PhoH-like protein; Region: PhoH; pfam02562
592021011164	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
592021011165	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
592021011166	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
592021011167	Yqey-like protein; Region: YqeY; pfam09424
592021011168	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
592021011169	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
592021011170	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
592021011171	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021011172	FeS/SAM binding site; other site
592021011173	TRAM domain; Region: TRAM; cl01282
592021011174	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
592021011175	RNA methyltransferase, RsmE family; Region: TIGR00046
592021011176	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
592021011177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021011178	S-adenosylmethionine binding site [chemical binding]; other site
592021011179	chaperone protein DnaJ; Provisional; Region: PRK14280
592021011180	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
592021011181	HSP70 interaction site [polypeptide binding]; other site
592021011182	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
592021011183	substrate binding site [polypeptide binding]; other site
592021011184	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
592021011185	Zn binding sites [ion binding]; other site
592021011186	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
592021011187	dimer interface [polypeptide binding]; other site
592021011188	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
592021011189	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
592021011190	nucleotide binding site [chemical binding]; other site
592021011191	NEF interaction site [polypeptide binding]; other site
592021011192	SBD interface [polypeptide binding]; other site
592021011193	GrpE; Region: GrpE; pfam01025
592021011194	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
592021011195	dimer interface [polypeptide binding]; other site
592021011196	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
592021011197	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
592021011198	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
592021011199	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
592021011200	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021011201	FeS/SAM binding site; other site
592021011202	HemN C-terminal domain; Region: HemN_C; pfam06969
592021011203	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021011204	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
592021011205	GTP-binding protein LepA; Provisional; Region: PRK05433
592021011206	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
592021011207	G1 box; other site
592021011208	putative GEF interaction site [polypeptide binding]; other site
592021011209	GTP/Mg2+ binding site [chemical binding]; other site
592021011210	Switch I region; other site
592021011211	G2 box; other site
592021011212	G3 box; other site
592021011213	Switch II region; other site
592021011214	G4 box; other site
592021011215	G5 box; other site
592021011216	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
592021011217	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
592021011218	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
592021011219	Protein of unknown function (DUF3679); Region: DUF3679; pfam12438
592021011220	germination protease; Provisional; Region: PRK02858
592021011221	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
592021011222	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
592021011223	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
592021011224	YqzM-like protein; Region: YqzM; pfam14141
592021011225	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
592021011226	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
592021011227	Competence protein; Region: Competence; pfam03772
592021011228	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021011229	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
592021011230	catalytic motif [active]
592021011231	Zn binding site [ion binding]; other site
592021011232	SLBB domain; Region: SLBB; pfam10531
592021011233	comEA protein; Region: comE; TIGR01259
592021011234	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
592021011235	late competence protein ComER; Validated; Region: PRK07680
592021011236	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
592021011237	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
592021011238	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021011239	S-adenosylmethionine binding site [chemical binding]; other site
592021011240	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
592021011241	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021011242	Zn2+ binding site [ion binding]; other site
592021011243	Mg2+ binding site [ion binding]; other site
592021011244	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
592021011245	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
592021011246	active site
592021011247	(T/H)XGH motif; other site
592021011248	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
592021011249	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
592021011250	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
592021011251	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
592021011252	shikimate binding site; other site
592021011253	NAD(P) binding site [chemical binding]; other site
592021011254	GTPase YqeH; Provisional; Region: PRK13796
592021011255	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
592021011256	GTP/Mg2+ binding site [chemical binding]; other site
592021011257	G4 box; other site
592021011258	G5 box; other site
592021011259	G1 box; other site
592021011260	Switch I region; other site
592021011261	G2 box; other site
592021011262	G3 box; other site
592021011263	Switch II region; other site
592021011264	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
592021011265	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021011266	active site
592021011267	motif I; other site
592021011268	motif II; other site
592021011269	Sporulation inhibitor A; Region: Sda; pfam08970
592021011270	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
592021011271	sporulation sigma factor SigK; Reviewed; Region: PRK05803
592021011272	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021011273	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021011274	DNA binding residues [nucleotide binding]
592021011275	Peptidase propeptide and YPEB domain; Region: PepSY; cl15480
592021011276	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
592021011277	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
592021011278	dimer interface [polypeptide binding]; other site
592021011279	FMN binding site [chemical binding]; other site
592021011280	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
592021011281	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
592021011282	synthetase active site [active]
592021011283	NTP binding site [chemical binding]; other site
592021011284	metal binding site [ion binding]; metal-binding site
592021011285	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
592021011286	dimer interface [polypeptide binding]; other site
592021011287	Alkaline phosphatase homologues; Region: alkPPc; smart00098
592021011288	active site
592021011289	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
592021011290	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021011291	Coenzyme A binding pocket [chemical binding]; other site
592021011292	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
592021011293	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021011294	DoxX; Region: DoxX; cl17842
592021011295	CHAT domain; Region: CHAT; cl17868
592021011296	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
592021011297	catalytic core [active]
592021011298	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
592021011299	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
592021011300	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
592021011301	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
592021011302	putative active site [active]
592021011303	catalytic triad [active]
592021011304	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
592021011305	putative integrin binding motif; other site
592021011306	PA/protease domain interface [polypeptide binding]; other site
592021011307	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
592021011308	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
592021011309	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
592021011310	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
592021011311	cofactor binding site; other site
592021011312	metal binding site [ion binding]; metal-binding site
592021011313	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
592021011314	aromatic arch; other site
592021011315	DCoH dimer interaction site [polypeptide binding]; other site
592021011316	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
592021011317	DCoH tetramer interaction site [polypeptide binding]; other site
592021011318	substrate binding site [chemical binding]; other site
592021011319	Predicted membrane protein [Function unknown]; Region: COG2259
592021011320	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
592021011321	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021011322	non-specific DNA binding site [nucleotide binding]; other site
592021011323	salt bridge; other site
592021011324	sequence-specific DNA binding site [nucleotide binding]; other site
592021011325	Cupin domain; Region: Cupin_2; pfam07883
592021011326	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
592021011327	dimer interaction site [polypeptide binding]; other site
592021011328	substrate-binding tunnel; other site
592021011329	active site
592021011330	catalytic site [active]
592021011331	substrate binding site [chemical binding]; other site
592021011332	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021011333	Coenzyme A binding pocket [chemical binding]; other site
592021011334	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021011335	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
592021011336	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
592021011337	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
592021011338	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
592021011339	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
592021011340	Walker A/P-loop; other site
592021011341	ATP binding site [chemical binding]; other site
592021011342	Q-loop/lid; other site
592021011343	ABC transporter signature motif; other site
592021011344	Walker B; other site
592021011345	D-loop; other site
592021011346	H-loop/switch region; other site
592021011347	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
592021011348	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021011349	ABC-ATPase subunit  interface; other site
592021011350	dimer interface [polypeptide binding]; other site
592021011351	putative PBP binding regions; other site
592021011352	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
592021011353	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
592021011354	intersubunit interface [polypeptide binding]; other site
592021011355	YrhC-like protein; Region: YrhC; pfam14143
592021011356	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
592021011357	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
592021011358	putative catalytic cysteine [active]
592021011359	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
592021011360	putative active site [active]
592021011361	metal binding site [ion binding]; metal-binding site
592021011362	cystathionine beta-lyase; Provisional; Region: PRK07671
592021011363	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
592021011364	homodimer interface [polypeptide binding]; other site
592021011365	substrate-cofactor binding pocket; other site
592021011366	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021011367	catalytic residue [active]
592021011368	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
592021011369	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
592021011370	dimer interface [polypeptide binding]; other site
592021011371	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021011372	catalytic residue [active]
592021011373	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
592021011374	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
592021011375	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021011376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021011377	S-adenosylmethionine binding site [chemical binding]; other site
592021011378	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
592021011379	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
592021011380	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
592021011381	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021011382	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
592021011383	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
592021011384	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
592021011385	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
592021011386	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
592021011387	ATP-binding site [chemical binding]; other site
592021011388	Sugar specificity; other site
592021011389	Pyrimidine base specificity; other site
592021011390	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
592021011391	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
592021011392	Peptidase family U32; Region: Peptidase_U32; pfam01136
592021011393	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
592021011394	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
592021011395	Peptidase family U32; Region: Peptidase_U32; pfam01136
592021011396	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
592021011397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021011398	S-adenosylmethionine binding site [chemical binding]; other site
592021011399	YceG-like family; Region: YceG; pfam02618
592021011400	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
592021011401	dimerization interface [polypeptide binding]; other site
592021011402	hypothetical protein; Provisional; Region: PRK13678
592021011403	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
592021011404	hypothetical protein; Provisional; Region: PRK05473
592021011405	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
592021011406	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
592021011407	motif 1; other site
592021011408	active site
592021011409	motif 2; other site
592021011410	motif 3; other site
592021011411	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
592021011412	DHHA1 domain; Region: DHHA1; pfam02272
592021011413	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
592021011414	Domain of unknown function DUF20; Region: UPF0118; pfam01594
592021011415	Protein of unknown function (DUF3918); Region: DUF3918; pfam13056
592021011416	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
592021011417	AAA domain; Region: AAA_30; pfam13604
592021011418	Family description; Region: UvrD_C_2; pfam13538
592021011419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021011420	TPR motif; other site
592021011421	TPR repeat; Region: TPR_11; pfam13414
592021011422	binding surface
592021011423	TPR repeat; Region: TPR_11; pfam13414
592021011424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021011425	binding surface
592021011426	TPR motif; other site
592021011427	TPR repeat; Region: TPR_11; pfam13414
592021011428	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
592021011429	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
592021011430	Ligand Binding Site [chemical binding]; other site
592021011431	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
592021011432	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
592021011433	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021011434	catalytic residue [active]
592021011435	Predicted transcriptional regulator [Transcription]; Region: COG1959
592021011436	Transcriptional regulator; Region: Rrf2; pfam02082
592021011437	recombination factor protein RarA; Reviewed; Region: PRK13342
592021011438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021011439	Walker A motif; other site
592021011440	ATP binding site [chemical binding]; other site
592021011441	Walker B motif; other site
592021011442	arginine finger; other site
592021011443	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
592021011444	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
592021011445	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
592021011446	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
592021011447	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
592021011448	putative ATP binding site [chemical binding]; other site
592021011449	putative substrate interface [chemical binding]; other site
592021011450	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
592021011451	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
592021011452	dimer interface [polypeptide binding]; other site
592021011453	anticodon binding site; other site
592021011454	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
592021011455	homodimer interface [polypeptide binding]; other site
592021011456	motif 1; other site
592021011457	active site
592021011458	motif 2; other site
592021011459	GAD domain; Region: GAD; pfam02938
592021011460	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
592021011461	motif 3; other site
592021011462	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
592021011463	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
592021011464	dimer interface [polypeptide binding]; other site
592021011465	motif 1; other site
592021011466	active site
592021011467	motif 2; other site
592021011468	motif 3; other site
592021011469	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
592021011470	anticodon binding site; other site
592021011471	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
592021011472	putative active site [active]
592021011473	dimerization interface [polypeptide binding]; other site
592021011474	putative tRNAtyr binding site [nucleotide binding]; other site
592021011475	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
592021011476	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021011477	Zn2+ binding site [ion binding]; other site
592021011478	Mg2+ binding site [ion binding]; other site
592021011479	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
592021011480	synthetase active site [active]
592021011481	NTP binding site [chemical binding]; other site
592021011482	metal binding site [ion binding]; metal-binding site
592021011483	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
592021011484	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
592021011485	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021011486	active site
592021011487	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
592021011488	DHH family; Region: DHH; pfam01368
592021011489	DHHA1 domain; Region: DHHA1; pfam02272
592021011490	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
592021011491	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
592021011492	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
592021011493	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
592021011494	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
592021011495	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
592021011496	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
592021011497	Protein export membrane protein; Region: SecD_SecF; pfam02355
592021011498	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
592021011499	stage V sporulation protein B; Region: spore_V_B; TIGR02900
592021011500	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
592021011501	Predicted membrane protein [Function unknown]; Region: COG2323
592021011502	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
592021011503	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
592021011504	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
592021011505	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
592021011506	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
592021011507	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
592021011508	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
592021011509	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
592021011510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021011511	Walker A motif; other site
592021011512	ATP binding site [chemical binding]; other site
592021011513	Walker B motif; other site
592021011514	arginine finger; other site
592021011515	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
592021011516	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
592021011517	RuvA N terminal domain; Region: RuvA_N; pfam01330
592021011518	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
592021011519	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
592021011520	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
592021011521	putative ligand binding residues [chemical binding]; other site
592021011522	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
592021011523	BofC C-terminal domain; Region: BofC_C; pfam08955
592021011524	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021011525	dimerization interface [polypeptide binding]; other site
592021011526	putative DNA binding site [nucleotide binding]; other site
592021011527	putative Zn2+ binding site [ion binding]; other site
592021011528	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
592021011529	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
592021011530	quinolinate synthetase; Provisional; Region: PRK09375
592021011531	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
592021011532	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
592021011533	dimerization interface [polypeptide binding]; other site
592021011534	active site
592021011535	L-aspartate oxidase; Provisional; Region: PRK08071
592021011536	L-aspartate oxidase; Provisional; Region: PRK06175
592021011537	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
592021011538	cysteine desulfurase; Provisional; Region: PRK02948
592021011539	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
592021011540	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021011541	catalytic residue [active]
592021011542	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
592021011543	HTH domain; Region: HTH_11; pfam08279
592021011544	3H domain; Region: 3H; pfam02829
592021011545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
592021011546	MOSC domain; Region: MOSC; pfam03473
592021011547	3-alpha domain; Region: 3-alpha; pfam03475
592021011548	prephenate dehydratase; Provisional; Region: PRK11898
592021011549	Prephenate dehydratase; Region: PDT; pfam00800
592021011550	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
592021011551	putative L-Phe binding site [chemical binding]; other site
592021011552	FtsX-like permease family; Region: FtsX; pfam02687
592021011553	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
592021011554	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
592021011555	FtsX-like permease family; Region: FtsX; pfam02687
592021011556	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021011557	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021011558	Walker A/P-loop; other site
592021011559	ATP binding site [chemical binding]; other site
592021011560	Q-loop/lid; other site
592021011561	ABC transporter signature motif; other site
592021011562	Walker B; other site
592021011563	D-loop; other site
592021011564	H-loop/switch region; other site
592021011565	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021011566	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021011567	active site
592021011568	phosphorylation site [posttranslational modification]
592021011569	intermolecular recognition site; other site
592021011570	dimerization interface [polypeptide binding]; other site
592021011571	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021011572	DNA binding site [nucleotide binding]
592021011573	GTPase CgtA; Reviewed; Region: obgE; PRK12297
592021011574	GTP1/OBG; Region: GTP1_OBG; pfam01018
592021011575	Obg GTPase; Region: Obg; cd01898
592021011576	G1 box; other site
592021011577	GTP/Mg2+ binding site [chemical binding]; other site
592021011578	Switch I region; other site
592021011579	G2 box; other site
592021011580	G3 box; other site
592021011581	Switch II region; other site
592021011582	G4 box; other site
592021011583	G5 box; other site
592021011584	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
592021011585	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
592021011586	hypothetical protein; Provisional; Region: PRK14553
592021011587	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
592021011588	Ribosomal protein L21 leader
592021011589	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
592021011590	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
592021011591	homodimer interface [polypeptide binding]; other site
592021011592	oligonucleotide binding site [chemical binding]; other site
592021011593	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
592021011594	Peptidase family M50; Region: Peptidase_M50; pfam02163
592021011595	active site
592021011596	putative substrate binding region [chemical binding]; other site
592021011597	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
592021011598	Peptidase family M23; Region: Peptidase_M23; pfam01551
592021011599	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
592021011600	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
592021011601	Switch I; other site
592021011602	Switch II; other site
592021011603	septum formation inhibitor; Reviewed; Region: minC; PRK00513
592021011604	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
592021011605	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
592021011606	rod shape-determining protein MreC; Provisional; Region: PRK13922
592021011607	rod shape-determining protein MreC; Region: MreC; pfam04085
592021011608	rod shape-determining protein MreB; Provisional; Region: PRK13927
592021011609	MreB and similar proteins; Region: MreB_like; cd10225
592021011610	nucleotide binding site [chemical binding]; other site
592021011611	Mg binding site [ion binding]; other site
592021011612	putative protofilament interaction site [polypeptide binding]; other site
592021011613	RodZ interaction site [polypeptide binding]; other site
592021011614	hypothetical protein; Reviewed; Region: PRK00024
592021011615	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
592021011616	MPN+ (JAMM) motif; other site
592021011617	Zinc-binding site [ion binding]; other site
592021011618	Maf-like protein; Region: Maf; pfam02545
592021011619	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
592021011620	active site
592021011621	dimer interface [polypeptide binding]; other site
592021011622	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
592021011623	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
592021011624	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
592021011625	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
592021011626	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
592021011627	active site
592021011628	HIGH motif; other site
592021011629	nucleotide binding site [chemical binding]; other site
592021011630	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
592021011631	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
592021011632	active site
592021011633	KMSKS motif; other site
592021011634	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
592021011635	tRNA binding surface [nucleotide binding]; other site
592021011636	anticodon binding site; other site
592021011637	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
592021011638	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
592021011639	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
592021011640	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
592021011641	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
592021011642	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
592021011643	inhibitor-cofactor binding pocket; inhibition site
592021011644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021011645	catalytic residue [active]
592021011646	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
592021011647	dimer interface [polypeptide binding]; other site
592021011648	active site
592021011649	Schiff base residues; other site
592021011650	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
592021011651	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
592021011652	active site
592021011653	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
592021011654	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
592021011655	domain interfaces; other site
592021011656	active site
592021011657	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
592021011658	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
592021011659	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
592021011660	tRNA; other site
592021011661	putative tRNA binding site [nucleotide binding]; other site
592021011662	putative NADP binding site [chemical binding]; other site
592021011663	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
592021011664	Transcriptional regulators [Transcription]; Region: MarR; COG1846
592021011665	MarR family; Region: MarR; pfam01047
592021011666	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
592021011667	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
592021011668	G1 box; other site
592021011669	GTP/Mg2+ binding site [chemical binding]; other site
592021011670	Switch I region; other site
592021011671	G2 box; other site
592021011672	G3 box; other site
592021011673	Switch II region; other site
592021011674	G4 box; other site
592021011675	G5 box; other site
592021011676	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
592021011677	Found in ATP-dependent protease La (LON); Region: LON; smart00464
592021011678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021011679	Walker A motif; other site
592021011680	ATP binding site [chemical binding]; other site
592021011681	Walker B motif; other site
592021011682	arginine finger; other site
592021011683	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
592021011684	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
592021011685	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021011686	Walker A motif; other site
592021011687	ATP binding site [chemical binding]; other site
592021011688	Walker B motif; other site
592021011689	arginine finger; other site
592021011690	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
592021011691	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
592021011692	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
592021011693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021011694	Walker A motif; other site
592021011695	ATP binding site [chemical binding]; other site
592021011696	Walker B motif; other site
592021011697	arginine finger; other site
592021011698	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
592021011699	trigger factor; Provisional; Region: tig; PRK01490
592021011700	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
592021011701	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
592021011702	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
592021011703	pentamer interface [polypeptide binding]; other site
592021011704	dodecaamer interface [polypeptide binding]; other site
592021011705	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
592021011706	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
592021011707	active site
592021011708	metal binding site [ion binding]; metal-binding site
592021011709	homotetramer interface [polypeptide binding]; other site
592021011710	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
592021011711	active site
592021011712	dimerization interface [polypeptide binding]; other site
592021011713	ribonuclease PH; Reviewed; Region: rph; PRK00173
592021011714	Ribonuclease PH; Region: RNase_PH_bact; cd11362
592021011715	hexamer interface [polypeptide binding]; other site
592021011716	active site
592021011717	Sporulation and spore germination; Region: Germane; pfam10646
592021011718	Spore germination protein [General function prediction only]; Region: COG5401
592021011719	Sporulation and spore germination; Region: Germane; pfam10646
592021011720	glutamate racemase; Provisional; Region: PRK00865
592021011721	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
592021011722	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
592021011723	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
592021011724	potential catalytic triad [active]
592021011725	conserved cys residue [active]
592021011726	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021011727	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021011728	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
592021011729	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
592021011730	potential catalytic triad [active]
592021011731	conserved cys residue [active]
592021011732	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
592021011733	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
592021011734	DNA binding residues [nucleotide binding]
592021011735	dimerization interface [polypeptide binding]; other site
592021011736	putative uracil/xanthine transporter; Provisional; Region: PRK11412
592021011737	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021011738	EamA-like transporter family; Region: EamA; pfam00892
592021011739	EamA-like transporter family; Region: EamA; pfam00892
592021011740	putative deaminase; Validated; Region: PRK06846
592021011741	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
592021011742	active site
592021011743	putative deaminase; Validated; Region: PRK06846
592021011744	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
592021011745	active site
592021011746	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
592021011747	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
592021011748	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
592021011749	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
592021011750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021011751	dimer interface [polypeptide binding]; other site
592021011752	conserved gate region; other site
592021011753	ABC-ATPase subunit interface; other site
592021011754	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
592021011755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021011756	dimer interface [polypeptide binding]; other site
592021011757	conserved gate region; other site
592021011758	putative PBP binding loops; other site
592021011759	ABC-ATPase subunit interface; other site
592021011760	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
592021011761	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021011762	Walker A/P-loop; other site
592021011763	ATP binding site [chemical binding]; other site
592021011764	Q-loop/lid; other site
592021011765	ABC transporter signature motif; other site
592021011766	Walker B; other site
592021011767	D-loop; other site
592021011768	H-loop/switch region; other site
592021011769	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
592021011770	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
592021011771	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
592021011772	Walker A/P-loop; other site
592021011773	ATP binding site [chemical binding]; other site
592021011774	Q-loop/lid; other site
592021011775	ABC transporter signature motif; other site
592021011776	Walker B; other site
592021011777	D-loop; other site
592021011778	H-loop/switch region; other site
592021011779	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
592021011780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021011781	Response regulator receiver domain; Region: Response_reg; pfam00072
592021011782	active site
592021011783	phosphorylation site [posttranslational modification]
592021011784	intermolecular recognition site; other site
592021011785	dimerization interface [polypeptide binding]; other site
592021011786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021011787	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
592021011788	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021011789	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
592021011790	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
592021011791	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021011792	non-specific DNA binding site [nucleotide binding]; other site
592021011793	salt bridge; other site
592021011794	sequence-specific DNA binding site [nucleotide binding]; other site
592021011795	Cupin domain; Region: Cupin_2; pfam07883
592021011796	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
592021011797	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
592021011798	amphipathic channel; other site
592021011799	Asn-Pro-Ala signature motifs; other site
592021011800	Predicted transcriptional regulator [Transcription]; Region: COG1959
592021011801	Transcriptional regulator; Region: Rrf2; pfam02082
592021011802	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
592021011803	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
592021011804	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021011805	Walker A/P-loop; other site
592021011806	ATP binding site [chemical binding]; other site
592021011807	Q-loop/lid; other site
592021011808	ABC transporter signature motif; other site
592021011809	Walker B; other site
592021011810	D-loop; other site
592021011811	H-loop/switch region; other site
592021011812	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
592021011813	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021011814	active site
592021011815	motif I; other site
592021011816	motif II; other site
592021011817	flagellar motor protein MotA; Validated; Region: PRK08124
592021011818	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
592021011819	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
592021011820	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
592021011821	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
592021011822	active site
592021011823	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
592021011824	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
592021011825	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
592021011826	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
592021011827	L-aspartate oxidase; Provisional; Region: PRK06175
592021011828	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
592021011829	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
592021011830	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
592021011831	putative Iron-sulfur protein interface [polypeptide binding]; other site
592021011832	proximal heme binding site [chemical binding]; other site
592021011833	distal heme binding site [chemical binding]; other site
592021011834	putative dimer interface [polypeptide binding]; other site
592021011835	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
592021011836	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
592021011837	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
592021011838	GIY-YIG motif/motif A; other site
592021011839	active site
592021011840	catalytic site [active]
592021011841	putative DNA binding site [nucleotide binding]; other site
592021011842	metal binding site [ion binding]; metal-binding site
592021011843	UvrB/uvrC motif; Region: UVR; pfam02151
592021011844	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
592021011845	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
592021011846	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
592021011847	catalytic residues [active]
592021011848	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
592021011849	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
592021011850	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
592021011851	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
592021011852	Ligand binding site [chemical binding]; other site
592021011853	Electron transfer flavoprotein domain; Region: ETF; pfam01012
592021011854	enoyl-CoA hydratase; Provisional; Region: PRK07658
592021011855	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
592021011856	substrate binding site [chemical binding]; other site
592021011857	oxyanion hole (OAH) forming residues; other site
592021011858	trimer interface [polypeptide binding]; other site
592021011859	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
592021011860	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021011861	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021011862	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
592021011863	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
592021011864	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
592021011865	acyl-activating enzyme (AAE) consensus motif; other site
592021011866	putative AMP binding site [chemical binding]; other site
592021011867	putative active site [active]
592021011868	putative CoA binding site [chemical binding]; other site
592021011869	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
592021011870	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021011871	ABC-ATPase subunit  interface; other site
592021011872	dimer interface [polypeptide binding]; other site
592021011873	putative PBP binding regions; other site
592021011874	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021011875	ABC-ATPase subunit  interface; other site
592021011876	dimer interface [polypeptide binding]; other site
592021011877	putative PBP binding regions; other site
592021011878	DinB family; Region: DinB; cl17821
592021011879	DinB superfamily; Region: DinB_2; pfam12867
592021011880	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
592021011881	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
592021011882	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
592021011883	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021011884	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
592021011885	Walker A/P-loop; other site
592021011886	ATP binding site [chemical binding]; other site
592021011887	Q-loop/lid; other site
592021011888	ABC transporter signature motif; other site
592021011889	Walker B; other site
592021011890	D-loop; other site
592021011891	H-loop/switch region; other site
592021011892	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021011893	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021011894	dimer interface [polypeptide binding]; other site
592021011895	phosphorylation site [posttranslational modification]
592021011896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021011897	ATP binding site [chemical binding]; other site
592021011898	Mg2+ binding site [ion binding]; other site
592021011899	G-X-G motif; other site
592021011900	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021011901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021011902	active site
592021011903	phosphorylation site [posttranslational modification]
592021011904	intermolecular recognition site; other site
592021011905	dimerization interface [polypeptide binding]; other site
592021011906	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021011907	DNA binding site [nucleotide binding]
592021011908	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
592021011909	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
592021011910	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
592021011911	putative RNA binding site [nucleotide binding]; other site
592021011912	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
592021011913	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
592021011914	TrkA-N domain; Region: TrkA_N; pfam02254
592021011915	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314
592021011916	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
592021011917	active site
592021011918	catalytic site [active]
592021011919	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
592021011920	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
592021011921	Walker A/P-loop; other site
592021011922	ATP binding site [chemical binding]; other site
592021011923	Q-loop/lid; other site
592021011924	ABC transporter signature motif; other site
592021011925	Walker B; other site
592021011926	D-loop; other site
592021011927	H-loop/switch region; other site
592021011928	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
592021011929	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021011930	ABC-ATPase subunit  interface; other site
592021011931	dimer interface [polypeptide binding]; other site
592021011932	putative PBP binding regions; other site
592021011933	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
592021011934	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
592021011935	intersubunit interface [polypeptide binding]; other site
592021011936	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
592021011937	heme-binding site [chemical binding]; other site
592021011938	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
592021011939	heme-binding site [chemical binding]; other site
592021011940	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
592021011941	heme-binding site [chemical binding]; other site
592021011942	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
592021011943	heme-binding site [chemical binding]; other site
592021011944	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
592021011945	heme-binding site [chemical binding]; other site
592021011946	heme uptake protein IsdC; Region: IsdC; TIGR03656
592021011947	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
592021011948	heme-binding site [chemical binding]; other site
592021011949	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
592021011950	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
592021011951	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
592021011952	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021011953	RNA binding surface [nucleotide binding]; other site
592021011954	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
592021011955	probable active site [active]
592021011956	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
592021011957	MutS domain III; Region: MutS_III; pfam05192
592021011958	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
592021011959	Walker A/P-loop; other site
592021011960	ATP binding site [chemical binding]; other site
592021011961	Q-loop/lid; other site
592021011962	ABC transporter signature motif; other site
592021011963	Walker B; other site
592021011964	D-loop; other site
592021011965	H-loop/switch region; other site
592021011966	Smr domain; Region: Smr; pfam01713
592021011967	hypothetical protein; Provisional; Region: PRK08609
592021011968	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
592021011969	active site
592021011970	primer binding site [nucleotide binding]; other site
592021011971	NTP  binding site [chemical binding]; other site
592021011972	metal binding triad [ion binding]; metal-binding site
592021011973	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
592021011974	active site
592021011975	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
592021011976	Colicin V production protein; Region: Colicin_V; pfam02674
592021011977	cell division protein ZapA; Provisional; Region: PRK14126
592021011978	ribonuclease HIII; Provisional; Region: PRK00996
592021011979	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
592021011980	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
592021011981	RNA/DNA hybrid binding site [nucleotide binding]; other site
592021011982	active site
592021011983	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
592021011984	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
592021011985	putative dimer interface [polypeptide binding]; other site
592021011986	putative anticodon binding site; other site
592021011987	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
592021011988	homodimer interface [polypeptide binding]; other site
592021011989	motif 1; other site
592021011990	motif 2; other site
592021011991	active site
592021011992	motif 3; other site
592021011993	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
592021011994	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
592021011995	putative tRNA-binding site [nucleotide binding]; other site
592021011996	B3/4 domain; Region: B3_4; pfam03483
592021011997	tRNA synthetase B5 domain; Region: B5; smart00874
592021011998	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
592021011999	dimer interface [polypeptide binding]; other site
592021012000	motif 1; other site
592021012001	motif 3; other site
592021012002	motif 2; other site
592021012003	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
592021012004	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
592021012005	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
592021012006	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
592021012007	dimer interface [polypeptide binding]; other site
592021012008	motif 1; other site
592021012009	active site
592021012010	motif 2; other site
592021012011	motif 3; other site
592021012012	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
592021012013	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
592021012014	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
592021012015	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
592021012016	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021012017	Zn2+ binding site [ion binding]; other site
592021012018	Mg2+ binding site [ion binding]; other site
592021012019	CAAX protease self-immunity; Region: Abi; pfam02517
592021012020	CAAX protease self-immunity; Region: Abi; pfam02517
592021012021	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
592021012022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021012023	putative substrate translocation pore; other site
592021012024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021012025	HlyD family secretion protein; Region: HlyD_3; pfam13437
592021012026	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021012027	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021012028	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
592021012029	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
592021012030	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
592021012031	oligomer interface [polypeptide binding]; other site
592021012032	active site
592021012033	metal binding site [ion binding]; metal-binding site
592021012034	dUTPase; Region: dUTPase_2; pfam08761
592021012035	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
592021012036	active site
592021012037	homodimer interface [polypeptide binding]; other site
592021012038	metal binding site [ion binding]; metal-binding site
592021012039	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
592021012040	23S rRNA binding site [nucleotide binding]; other site
592021012041	L21 binding site [polypeptide binding]; other site
592021012042	L13 binding site [polypeptide binding]; other site
592021012043	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
592021012044	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
592021012045	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
592021012046	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
592021012047	Ribosomal protein L20 leader
592021012048	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
592021012049	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
592021012050	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
592021012051	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
592021012052	active site
592021012053	dimer interface [polypeptide binding]; other site
592021012054	motif 1; other site
592021012055	motif 2; other site
592021012056	motif 3; other site
592021012057	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
592021012058	anticodon binding site; other site
592021012059	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
592021012060	primosomal protein DnaI; Reviewed; Region: PRK08939
592021012061	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
592021012062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021012063	Walker A motif; other site
592021012064	ATP binding site [chemical binding]; other site
592021012065	Walker B motif; other site
592021012066	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
592021012067	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
592021012068	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
592021012069	ATP cone domain; Region: ATP-cone; pfam03477
592021012070	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
592021012071	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
592021012072	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
592021012073	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
592021012074	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
592021012075	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
592021012076	CoA-binding site [chemical binding]; other site
592021012077	ATP-binding [chemical binding]; other site
592021012078	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
592021012079	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
592021012080	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
592021012081	DNA binding site [nucleotide binding]
592021012082	catalytic residue [active]
592021012083	H2TH interface [polypeptide binding]; other site
592021012084	putative catalytic residues [active]
592021012085	turnover-facilitating residue; other site
592021012086	intercalation triad [nucleotide binding]; other site
592021012087	8OG recognition residue [nucleotide binding]; other site
592021012088	putative reading head residues; other site
592021012089	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
592021012090	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
592021012091	DNA polymerase I; Provisional; Region: PRK05755
592021012092	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
592021012093	active site
592021012094	metal binding site 1 [ion binding]; metal-binding site
592021012095	putative 5' ssDNA interaction site; other site
592021012096	metal binding site 3; metal-binding site
592021012097	metal binding site 2 [ion binding]; metal-binding site
592021012098	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
592021012099	putative DNA binding site [nucleotide binding]; other site
592021012100	putative metal binding site [ion binding]; other site
592021012101	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
592021012102	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
592021012103	active site
592021012104	DNA binding site [nucleotide binding]
592021012105	catalytic site [active]
592021012106	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021012107	dimerization interface [polypeptide binding]; other site
592021012108	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
592021012109	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021012110	putative active site [active]
592021012111	heme pocket [chemical binding]; other site
592021012112	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021012113	dimer interface [polypeptide binding]; other site
592021012114	phosphorylation site [posttranslational modification]
592021012115	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021012116	ATP binding site [chemical binding]; other site
592021012117	Mg2+ binding site [ion binding]; other site
592021012118	G-X-G motif; other site
592021012119	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021012120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021012121	active site
592021012122	phosphorylation site [posttranslational modification]
592021012123	intermolecular recognition site; other site
592021012124	dimerization interface [polypeptide binding]; other site
592021012125	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021012126	DNA binding site [nucleotide binding]
592021012127	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
592021012128	active site 2 [active]
592021012129	active site 1 [active]
592021012130	malate dehydrogenase; Reviewed; Region: PRK06223
592021012131	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
592021012132	NAD(P) binding site [chemical binding]; other site
592021012133	dimer interface [polypeptide binding]; other site
592021012134	tetramer (dimer of dimers) interface [polypeptide binding]; other site
592021012135	substrate binding site [chemical binding]; other site
592021012136	isocitrate dehydrogenase; Reviewed; Region: PRK07006
592021012137	isocitrate dehydrogenase; Validated; Region: PRK07362
592021012138	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
592021012139	dimer interface [polypeptide binding]; other site
592021012140	Citrate synthase; Region: Citrate_synt; pfam00285
592021012141	active site
592021012142	citrylCoA binding site [chemical binding]; other site
592021012143	oxalacetate/citrate binding site [chemical binding]; other site
592021012144	coenzyme A binding site [chemical binding]; other site
592021012145	catalytic triad [active]
592021012146	Protein of unknown function (DUF441); Region: DUF441; pfam04284
592021012147	sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872
592021012148	Domain of unknown function DUF20; Region: UPF0118; pfam01594
592021012149	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
592021012150	pyruvate kinase; Provisional; Region: PRK06354
592021012151	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
592021012152	domain interfaces; other site
592021012153	active site
592021012154	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
592021012155	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
592021012156	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
592021012157	active site
592021012158	ADP/pyrophosphate binding site [chemical binding]; other site
592021012159	dimerization interface [polypeptide binding]; other site
592021012160	allosteric effector site; other site
592021012161	fructose-1,6-bisphosphate binding site; other site
592021012162	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
592021012163	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
592021012164	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
592021012165	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
592021012166	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
592021012167	Transcriptional regulators [Transcription]; Region: FadR; COG2186
592021012168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021012169	DNA-binding site [nucleotide binding]; DNA binding site
592021012170	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
592021012171	Malic enzyme, N-terminal domain; Region: malic; pfam00390
592021012172	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
592021012173	putative NAD(P) binding site [chemical binding]; other site
592021012174	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
592021012175	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
592021012176	active site
592021012177	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
592021012178	generic binding surface II; other site
592021012179	generic binding surface I; other site
592021012180	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
592021012181	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
592021012182	DHH family; Region: DHH; pfam01368
592021012183	DHHA1 domain; Region: DHHA1; pfam02272
592021012184	YtpI-like protein; Region: YtpI; pfam14007
592021012185	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
592021012186	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
592021012187	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021012188	DNA-binding site [nucleotide binding]; DNA binding site
592021012189	DRTGG domain; Region: DRTGG; pfam07085
592021012190	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
592021012191	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
592021012192	active site 2 [active]
592021012193	active site 1 [active]
592021012194	metal-dependent hydrolase; Provisional; Region: PRK00685
592021012195	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
592021012196	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
592021012197	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
592021012198	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
592021012199	active site
592021012200	Protein of unknown function (DUF3221); Region: DUF3221; pfam11518
592021012201	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
592021012202	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
592021012203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021012204	Coenzyme A binding pocket [chemical binding]; other site
592021012205	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
592021012206	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021012207	Coenzyme A binding pocket [chemical binding]; other site
592021012208	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
592021012209	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021012210	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021012211	non-specific DNA binding site [nucleotide binding]; other site
592021012212	salt bridge; other site
592021012213	sequence-specific DNA binding site [nucleotide binding]; other site
592021012214	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
592021012215	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
592021012216	hexamer interface [polypeptide binding]; other site
592021012217	ligand binding site [chemical binding]; other site
592021012218	putative active site [active]
592021012219	NAD(P) binding site [chemical binding]; other site
592021012220	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
592021012221	classical (c) SDRs; Region: SDR_c; cd05233
592021012222	NAD(P) binding site [chemical binding]; other site
592021012223	active site
592021012224	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
592021012225	Ligand Binding Site [chemical binding]; other site
592021012226	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
592021012227	argininosuccinate lyase; Provisional; Region: PRK00855
592021012228	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
592021012229	active sites [active]
592021012230	tetramer interface [polypeptide binding]; other site
592021012231	argininosuccinate synthase; Provisional; Region: PRK13820
592021012232	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
592021012233	ANP binding site [chemical binding]; other site
592021012234	Substrate Binding Site II [chemical binding]; other site
592021012235	Substrate Binding Site I [chemical binding]; other site
592021012236	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021012237	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021012238	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021012239	EcsC protein family; Region: EcsC; pfam12787
592021012240	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
592021012241	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
592021012242	nudix motif; other site
592021012243	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
592021012244	propionate/acetate kinase; Provisional; Region: PRK12379
592021012245	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
592021012246	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021012247	S-adenosylmethionine binding site [chemical binding]; other site
592021012248	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
592021012249	dimer interface [polypeptide binding]; other site
592021012250	catalytic triad [active]
592021012251	peroxidatic and resolving cysteines [active]
592021012252	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
592021012253	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
592021012254	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
592021012255	ATP-NAD kinase; Region: NAD_kinase; pfam01513
592021012256	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
592021012257	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
592021012258	active site
592021012259	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021012260	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
592021012261	dimer interface [polypeptide binding]; other site
592021012262	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
592021012263	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
592021012264	active site
592021012265	acyl-activating enzyme (AAE) consensus motif; other site
592021012266	putative CoA binding site [chemical binding]; other site
592021012267	AMP binding site [chemical binding]; other site
592021012268	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
592021012269	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
592021012270	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
592021012271	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
592021012272	Ligand Binding Site [chemical binding]; other site
592021012273	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
592021012274	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
592021012275	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021012276	catalytic residue [active]
592021012277	septation ring formation regulator EzrA; Provisional; Region: PRK04778
592021012278	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021012279	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021012280	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
592021012281	dimerization interface [polypeptide binding]; other site
592021012282	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021012283	EamA-like transporter family; Region: EamA; pfam00892
592021012284	EamA-like transporter family; Region: EamA; pfam00892
592021012285	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
592021012286	GAF domain; Region: GAF_2; pfam13185
592021012287	methionine gamma-lyase; Provisional; Region: PRK06767
592021012288	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
592021012289	homodimer interface [polypeptide binding]; other site
592021012290	substrate-cofactor binding pocket; other site
592021012291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021012292	catalytic residue [active]
592021012293	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
592021012294	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
592021012295	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021012296	RNA binding surface [nucleotide binding]; other site
592021012297	Domain of unknown function (DUF4306); Region: DUF4306; pfam14154
592021012298	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
592021012299	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
592021012300	active site
592021012301	HIGH motif; other site
592021012302	dimer interface [polypeptide binding]; other site
592021012303	KMSKS motif; other site
592021012304	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021012305	RNA binding surface [nucleotide binding]; other site
592021012306	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
592021012307	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021012308	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021012309	DNA binding residues [nucleotide binding]
592021012310	acetyl-CoA synthetase; Provisional; Region: PRK04319
592021012311	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
592021012312	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
592021012313	active site
592021012314	acyl-activating enzyme (AAE) consensus motif; other site
592021012315	putative CoA binding site [chemical binding]; other site
592021012316	AMP binding site [chemical binding]; other site
592021012317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021012318	Coenzyme A binding pocket [chemical binding]; other site
592021012319	FOG: CBS domain [General function prediction only]; Region: COG0517
592021012320	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
592021012321	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
592021012322	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
592021012323	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
592021012324	active site
592021012325	Zn binding site [ion binding]; other site
592021012326	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021012327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021012328	active site
592021012329	phosphorylation site [posttranslational modification]
592021012330	intermolecular recognition site; other site
592021012331	dimerization interface [polypeptide binding]; other site
592021012332	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021012333	DNA binding site [nucleotide binding]
592021012334	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021012335	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021012336	dimerization interface [polypeptide binding]; other site
592021012337	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021012338	dimer interface [polypeptide binding]; other site
592021012339	phosphorylation site [posttranslational modification]
592021012340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021012341	ATP binding site [chemical binding]; other site
592021012342	Mg2+ binding site [ion binding]; other site
592021012343	G-X-G motif; other site
592021012344	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
592021012345	Ankyrin repeat; Region: Ank; pfam00023
592021012346	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
592021012347	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
592021012348	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
592021012349	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
592021012350	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
592021012351	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
592021012352	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
592021012353	Protein of unknown function (DUF3917); Region: DUF3917; pfam13055
592021012354	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
592021012355	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
592021012356	catabolite control protein A; Region: ccpA; TIGR01481
592021012357	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021012358	DNA binding site [nucleotide binding]
592021012359	domain linker motif; other site
592021012360	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
592021012361	dimerization interface [polypeptide binding]; other site
592021012362	effector binding site; other site
592021012363	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
592021012364	putative dimer interface [polypeptide binding]; other site
592021012365	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
592021012366	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
592021012367	putative dimer interface [polypeptide binding]; other site
592021012368	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
592021012369	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
592021012370	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
592021012371	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
592021012372	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
592021012373	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021012374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021012375	Coenzyme A binding pocket [chemical binding]; other site
592021012376	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
592021012377	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
592021012378	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
592021012379	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
592021012380	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
592021012381	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
592021012382	active site
592021012383	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
592021012384	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
592021012385	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
592021012386	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
592021012387	putative tRNA-binding site [nucleotide binding]; other site
592021012388	hypothetical protein; Provisional; Region: PRK13668
592021012389	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
592021012390	catalytic residues [active]
592021012391	NTPase; Reviewed; Region: PRK03114
592021012392	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
592021012393	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
592021012394	oligomer interface [polypeptide binding]; other site
592021012395	active site
592021012396	metal binding site [ion binding]; metal-binding site
592021012397	Predicted small secreted protein [Function unknown]; Region: COG5584
592021012398	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021012399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021012400	S-adenosylmethionine binding site [chemical binding]; other site
592021012401	YtzH-like protein; Region: YtzH; pfam14165
592021012402	Phosphotransferase enzyme family; Region: APH; pfam01636
592021012403	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
592021012404	active site
592021012405	substrate binding site [chemical binding]; other site
592021012406	ATP binding site [chemical binding]; other site
592021012407	pullulanase, type I; Region: pulA_typeI; TIGR02104
592021012408	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
592021012409	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
592021012410	Ca binding site [ion binding]; other site
592021012411	active site
592021012412	catalytic site [active]
592021012413	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
592021012414	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
592021012415	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
592021012416	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
592021012417	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
592021012418	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
592021012419	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021012420	RNA binding surface [nucleotide binding]; other site
592021012421	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
592021012422	active site
592021012423	uracil binding [chemical binding]; other site
592021012424	stage V sporulation protein B; Region: spore_V_B; TIGR02900
592021012425	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
592021012426	HI0933-like protein; Region: HI0933_like; pfam03486
592021012427	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021012428	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
592021012429	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021012430	putative substrate translocation pore; other site
592021012431	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021012432	dimerization interface [polypeptide binding]; other site
592021012433	putative DNA binding site [nucleotide binding]; other site
592021012434	putative Zn2+ binding site [ion binding]; other site
592021012435	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
592021012436	putative hydrophobic ligand binding site [chemical binding]; other site
592021012437	Domain of unknown function (DUF3973); Region: DUF3973; pfam13119
592021012438	Protein of unknown function (DUF2758); Region: DUF2758; pfam10957
592021012439	Protein of unknown function (DUF2553); Region: DUF2553; pfam10830
592021012440	glucose-1-dehydrogenase; Provisional; Region: PRK08936
592021012441	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
592021012442	NAD binding site [chemical binding]; other site
592021012443	homodimer interface [polypeptide binding]; other site
592021012444	active site
592021012445	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
592021012446	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
592021012447	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
592021012448	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
592021012449	MoaE interaction surface [polypeptide binding]; other site
592021012450	MoeB interaction surface [polypeptide binding]; other site
592021012451	thiocarboxylated glycine; other site
592021012452	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
592021012453	MoaE homodimer interface [polypeptide binding]; other site
592021012454	MoaD interaction [polypeptide binding]; other site
592021012455	active site residues [active]
592021012456	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
592021012457	Walker A motif; other site
592021012458	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
592021012459	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
592021012460	dimer interface [polypeptide binding]; other site
592021012461	putative functional site; other site
592021012462	putative MPT binding site; other site
592021012463	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
592021012464	trimer interface [polypeptide binding]; other site
592021012465	dimer interface [polypeptide binding]; other site
592021012466	putative active site [active]
592021012467	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
592021012468	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
592021012469	ATP binding site [chemical binding]; other site
592021012470	substrate interface [chemical binding]; other site
592021012471	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
592021012472	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
592021012473	active site residue [active]
592021012474	homoserine O-acetyltransferase; Provisional; Region: PRK06765
592021012475	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
592021012476	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
592021012477	Spore germination protein; Region: Spore_permease; pfam03845
592021012478	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
592021012479	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
592021012480	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
592021012481	putative nucleotide binding site [chemical binding]; other site
592021012482	putative metal binding site [ion binding]; other site
592021012483	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
592021012484	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
592021012485	HIGH motif; other site
592021012486	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
592021012487	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
592021012488	active site
592021012489	KMSKS motif; other site
592021012490	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
592021012491	tRNA binding surface [nucleotide binding]; other site
592021012492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021012493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021012494	putative substrate translocation pore; other site
592021012495	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
592021012496	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
592021012497	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
592021012498	TrkA-C domain; Region: TrkA_C; pfam02080
592021012499	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
592021012500	Int/Topo IB signature motif; other site
592021012501	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
592021012502	FtsX-like permease family; Region: FtsX; pfam02687
592021012503	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021012504	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021012505	Walker A/P-loop; other site
592021012506	ATP binding site [chemical binding]; other site
592021012507	Q-loop/lid; other site
592021012508	ABC transporter signature motif; other site
592021012509	Walker B; other site
592021012510	D-loop; other site
592021012511	H-loop/switch region; other site
592021012512	Protein of unknown function (DUF418); Region: DUF418; cl12135
592021012513	Protein of unknown function (DUF418); Region: DUF418; pfam04235
592021012514	Protein of unknown function (DUF2524); Region: DUF2524; pfam10732
592021012515	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
592021012516	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021012517	FeS/SAM binding site; other site
592021012518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021012519	S-adenosylmethionine binding site [chemical binding]; other site
592021012520	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021012521	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021012522	Walker A/P-loop; other site
592021012523	ATP binding site [chemical binding]; other site
592021012524	Q-loop/lid; other site
592021012525	ABC transporter signature motif; other site
592021012526	Walker B; other site
592021012527	D-loop; other site
592021012528	H-loop/switch region; other site
592021012529	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
592021012530	aspartate racemase; Region: asp_race; TIGR00035
592021012531	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
592021012532	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
592021012533	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
592021012534	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
592021012535	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
592021012536	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021012537	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
592021012538	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
592021012539	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
592021012540	trimer interface [polypeptide binding]; other site
592021012541	putative metal binding site [ion binding]; other site
592021012542	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
592021012543	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
592021012544	active site
592021012545	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
592021012546	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
592021012547	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
592021012548	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
592021012549	GTP binding site; other site
592021012550	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
592021012551	MPT binding site; other site
592021012552	trimer interface [polypeptide binding]; other site
592021012553	S-adenosylmethionine synthetase; Validated; Region: PRK05250
592021012554	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
592021012555	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
592021012556	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
592021012557	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
592021012558	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
592021012559	active site
592021012560	substrate-binding site [chemical binding]; other site
592021012561	metal-binding site [ion binding]
592021012562	ATP binding site [chemical binding]; other site
592021012563	ATP synthase I chain; Region: ATP_synt_I; pfam03899
592021012564	EamA-like transporter family; Region: EamA; pfam00892
592021012565	EamA-like transporter family; Region: EamA; pfam00892
592021012566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
592021012567	Uncharacterized conserved protein [Function unknown]; Region: COG0327
592021012568	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
592021012569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021012570	ATP binding site [chemical binding]; other site
592021012571	Mg2+ binding site [ion binding]; other site
592021012572	G-X-G motif; other site
592021012573	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021012574	dimer interface [polypeptide binding]; other site
592021012575	phosphorylation site [posttranslational modification]
592021012576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021012577	ATP binding site [chemical binding]; other site
592021012578	Mg2+ binding site [ion binding]; other site
592021012579	G-X-G motif; other site
592021012580	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
592021012581	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
592021012582	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
592021012583	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
592021012584	NMT1-like family; Region: NMT1_2; pfam13379
592021012585	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
592021012586	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
592021012587	Walker A/P-loop; other site
592021012588	ATP binding site [chemical binding]; other site
592021012589	Q-loop/lid; other site
592021012590	ABC transporter signature motif; other site
592021012591	Walker B; other site
592021012592	D-loop; other site
592021012593	H-loop/switch region; other site
592021012594	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
592021012595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021012596	dimer interface [polypeptide binding]; other site
592021012597	conserved gate region; other site
592021012598	putative PBP binding loops; other site
592021012599	ABC-ATPase subunit interface; other site
592021012600	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
592021012601	active site
592021012602	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
592021012603	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
592021012604	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
592021012605	nudix motif; other site
592021012606	Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606
592021012607	S-ribosylhomocysteinase; Provisional; Region: PRK02260
592021012608	Haemolytic domain; Region: Haemolytic; pfam01809
592021012609	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
592021012610	active site clefts [active]
592021012611	zinc binding site [ion binding]; other site
592021012612	dimer interface [polypeptide binding]; other site
592021012613	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
592021012614	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
592021012615	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
592021012616	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
592021012617	S-layer homology domain; Region: SLH; pfam00395
592021012618	S-layer homology domain; Region: SLH; pfam00395
592021012619	S-layer homology domain; Region: SLH; pfam00395
592021012620	Excalibur calcium-binding domain; Region: Excalibur; smart00894
592021012621	Uncharacterized conserved protein [Function unknown]; Region: COG1434
592021012622	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
592021012623	putative active site [active]
592021012624	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021012625	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021012626	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021012627	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021012628	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
592021012629	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
592021012630	Predicted membrane protein [Function unknown]; Region: COG3766
592021012631	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
592021012632	hypothetical protein; Provisional; Region: PRK12473
592021012633	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
592021012634	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
592021012635	G1 box; other site
592021012636	GTP/Mg2+ binding site [chemical binding]; other site
592021012637	Switch I region; other site
592021012638	G2 box; other site
592021012639	G3 box; other site
592021012640	Switch II region; other site
592021012641	G4 box; other site
592021012642	G5 box; other site
592021012643	Nucleoside recognition; Region: Gate; pfam07670
592021012644	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
592021012645	Nucleoside recognition; Region: Gate; pfam07670
592021012646	FeoA domain; Region: FeoA; pfam04023
592021012647	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
592021012648	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021012649	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021012650	dimerization interface [polypeptide binding]; other site
592021012651	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021012652	dimer interface [polypeptide binding]; other site
592021012653	phosphorylation site [posttranslational modification]
592021012654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021012655	ATP binding site [chemical binding]; other site
592021012656	Mg2+ binding site [ion binding]; other site
592021012657	G-X-G motif; other site
592021012658	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021012659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021012660	active site
592021012661	phosphorylation site [posttranslational modification]
592021012662	intermolecular recognition site; other site
592021012663	dimerization interface [polypeptide binding]; other site
592021012664	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021012665	DNA binding site [nucleotide binding]
592021012666	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
592021012667	active site
592021012668	catalytic site [active]
592021012669	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021012670	active site
592021012671	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
592021012672	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
592021012673	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
592021012674	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
592021012675	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
592021012676	putative hydrophobic ligand binding site [chemical binding]; other site
592021012677	protein interface [polypeptide binding]; other site
592021012678	gate; other site
592021012679	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021012680	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021012681	active site
592021012682	catalytic tetrad [active]
592021012683	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
592021012684	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
592021012685	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
592021012686	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021012687	S-adenosylmethionine binding site [chemical binding]; other site
592021012688	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
592021012689	FtsX-like permease family; Region: FtsX; pfam02687
592021012690	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021012691	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021012692	Walker A/P-loop; other site
592021012693	ATP binding site [chemical binding]; other site
592021012694	Q-loop/lid; other site
592021012695	ABC transporter signature motif; other site
592021012696	Walker B; other site
592021012697	D-loop; other site
592021012698	H-loop/switch region; other site
592021012699	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
592021012700	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
592021012701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
592021012702	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021012703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021012704	active site
592021012705	phosphorylation site [posttranslational modification]
592021012706	intermolecular recognition site; other site
592021012707	dimerization interface [polypeptide binding]; other site
592021012708	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021012709	DNA binding site [nucleotide binding]
592021012710	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021012711	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
592021012712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021012713	ATP binding site [chemical binding]; other site
592021012714	Mg2+ binding site [ion binding]; other site
592021012715	G-X-G motif; other site
592021012716	FtsX-like permease family; Region: FtsX; pfam02687
592021012717	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021012718	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021012719	Walker A/P-loop; other site
592021012720	ATP binding site [chemical binding]; other site
592021012721	Q-loop/lid; other site
592021012722	ABC transporter signature motif; other site
592021012723	Walker B; other site
592021012724	D-loop; other site
592021012725	H-loop/switch region; other site
592021012726	GntP family permease; Region: GntP_permease; pfam02447
592021012727	fructuronate transporter; Provisional; Region: PRK10034; cl15264
592021012728	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
592021012729	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
592021012730	DNA-binding site [nucleotide binding]; DNA binding site
592021012731	UTRA domain; Region: UTRA; pfam07702
592021012732	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
592021012733	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
592021012734	substrate binding site [chemical binding]; other site
592021012735	ATP binding site [chemical binding]; other site
592021012736	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
592021012737	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
592021012738	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021012739	catalytic residue [active]
592021012740	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
592021012741	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
592021012742	active site
592021012743	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
592021012744	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
592021012745	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
592021012746	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021012747	dimerization interface [polypeptide binding]; other site
592021012748	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021012749	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021012750	dimer interface [polypeptide binding]; other site
592021012751	phosphorylation site [posttranslational modification]
592021012752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021012753	ATP binding site [chemical binding]; other site
592021012754	Mg2+ binding site [ion binding]; other site
592021012755	G-X-G motif; other site
592021012756	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021012757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021012758	active site
592021012759	phosphorylation site [posttranslational modification]
592021012760	intermolecular recognition site; other site
592021012761	dimerization interface [polypeptide binding]; other site
592021012762	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021012763	DNA binding site [nucleotide binding]
592021012764	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
592021012765	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
592021012766	active site
592021012767	octamer interface [polypeptide binding]; other site
592021012768	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
592021012769	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
592021012770	acyl-activating enzyme (AAE) consensus motif; other site
592021012771	putative AMP binding site [chemical binding]; other site
592021012772	putative active site [active]
592021012773	putative CoA binding site [chemical binding]; other site
592021012774	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
592021012775	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
592021012776	substrate binding site [chemical binding]; other site
592021012777	oxyanion hole (OAH) forming residues; other site
592021012778	trimer interface [polypeptide binding]; other site
592021012779	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
592021012780	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
592021012781	nucleophilic elbow; other site
592021012782	catalytic triad; other site
592021012783	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
592021012784	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
592021012785	dimer interface [polypeptide binding]; other site
592021012786	tetramer interface [polypeptide binding]; other site
592021012787	PYR/PP interface [polypeptide binding]; other site
592021012788	TPP binding site [chemical binding]; other site
592021012789	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
592021012790	TPP-binding site; other site
592021012791	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
592021012792	chorismate binding enzyme; Region: Chorismate_bind; cl10555
592021012793	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
592021012794	UbiA prenyltransferase family; Region: UbiA; pfam01040
592021012795	regulatory protein, yteA family; Region: bacill_yteA; TIGR02890
592021012796	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
592021012797	DNA-binding site [nucleotide binding]; DNA binding site
592021012798	RNA-binding motif; other site
592021012799	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
592021012800	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
592021012801	active site flap/lid [active]
592021012802	nucleophilic elbow; other site
592021012803	catalytic triad [active]
592021012804	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
592021012805	homodimer interface [polypeptide binding]; other site
592021012806	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
592021012807	active site pocket [active]
592021012808	glycogen synthase; Provisional; Region: glgA; PRK00654
592021012809	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
592021012810	ADP-binding pocket [chemical binding]; other site
592021012811	homodimer interface [polypeptide binding]; other site
592021012812	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
592021012813	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
592021012814	ligand binding site; other site
592021012815	oligomer interface; other site
592021012816	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
592021012817	dimer interface [polypeptide binding]; other site
592021012818	N-terminal domain interface [polypeptide binding]; other site
592021012819	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
592021012820	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
592021012821	ligand binding site; other site
592021012822	oligomer interface; other site
592021012823	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
592021012824	dimer interface [polypeptide binding]; other site
592021012825	N-terminal domain interface [polypeptide binding]; other site
592021012826	sulfate 1 binding site; other site
592021012827	glycogen branching enzyme; Provisional; Region: PRK12313
592021012828	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
592021012829	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
592021012830	active site
592021012831	catalytic site [active]
592021012832	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
592021012833	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
592021012834	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
592021012835	tetramer (dimer of dimers) interface [polypeptide binding]; other site
592021012836	NAD binding site [chemical binding]; other site
592021012837	dimer interface [polypeptide binding]; other site
592021012838	substrate binding site [chemical binding]; other site
592021012839	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
592021012840	MgtC family; Region: MgtC; pfam02308
592021012841	Ion channel; Region: Ion_trans_2; pfam07885
592021012842	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
592021012843	TrkA-N domain; Region: TrkA_N; pfam02254
592021012844	YugN-like family; Region: YugN; pfam08868
592021012845	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
592021012846	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
592021012847	active site
592021012848	dimer interface [polypeptide binding]; other site
592021012849	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
592021012850	dimer interface [polypeptide binding]; other site
592021012851	active site
592021012852	Domain of unknown function (DUF378); Region: DUF378; pfam04070
592021012853	general stress protein 13; Validated; Region: PRK08059
592021012854	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
592021012855	RNA binding site [nucleotide binding]; other site
592021012856	hypothetical protein; Validated; Region: PRK07682
592021012857	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021012858	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021012859	homodimer interface [polypeptide binding]; other site
592021012860	catalytic residue [active]
592021012861	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
592021012862	AsnC family; Region: AsnC_trans_reg; pfam01037
592021012863	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
592021012864	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
592021012865	dimerization interface [polypeptide binding]; other site
592021012866	ligand binding site [chemical binding]; other site
592021012867	NADP binding site [chemical binding]; other site
592021012868	catalytic site [active]
592021012869	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
592021012870	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
592021012871	nucleophilic elbow; other site
592021012872	catalytic triad; other site
592021012873	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
592021012874	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
592021012875	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
592021012876	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021012877	homodimer interface [polypeptide binding]; other site
592021012878	catalytic residue [active]
592021012879	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
592021012880	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
592021012881	E-class dimer interface [polypeptide binding]; other site
592021012882	P-class dimer interface [polypeptide binding]; other site
592021012883	active site
592021012884	Cu2+ binding site [ion binding]; other site
592021012885	Zn2+ binding site [ion binding]; other site
592021012886	Protein of unknown function (DUF2681); Region: DUF2681; pfam10883
592021012887	Kinase associated protein B; Region: KapB; pfam08810
592021012888	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
592021012889	active site
592021012890	catalytic site [active]
592021012891	substrate binding site [chemical binding]; other site
592021012892	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
592021012893	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
592021012894	transmembrane helices; other site
592021012895	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
592021012896	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
592021012897	active site
592021012898	glycyl-tRNA synthetase; Provisional; Region: PRK04173
592021012899	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
592021012900	motif 1; other site
592021012901	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
592021012902	active site
592021012903	motif 2; other site
592021012904	motif 3; other site
592021012905	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
592021012906	anticodon binding site; other site
592021012907	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
592021012908	CoenzymeA binding site [chemical binding]; other site
592021012909	subunit interaction site [polypeptide binding]; other site
592021012910	PHB binding site; other site
592021012911	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
592021012912	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
592021012913	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
592021012914	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
592021012915	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
592021012916	active site
592021012917	tetramer interface; other site
592021012918	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
592021012919	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
592021012920	active site
592021012921	substrate binding site [chemical binding]; other site
592021012922	metal binding site [ion binding]; metal-binding site
592021012923	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
592021012924	Uncharacterized conserved protein [Function unknown]; Region: COG1624
592021012925	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
592021012926	multifunctional aminopeptidase A; Provisional; Region: PRK00913
592021012927	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
592021012928	interface (dimer of trimers) [polypeptide binding]; other site
592021012929	Substrate-binding/catalytic site; other site
592021012930	Zn-binding sites [ion binding]; other site
592021012931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
592021012932	Putative membrane protein; Region: YuiB; pfam14068
592021012933	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
592021012934	nudix motif; other site
592021012935	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
592021012936	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021012937	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
592021012938	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021012939	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021012940	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
592021012941	H+ Antiporter protein; Region: 2A0121; TIGR00900
592021012942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021012943	putative substrate translocation pore; other site
592021012944	Helix-turn-helix domain; Region: HTH_36; pfam13730
592021012945	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
592021012946	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
592021012947	putative DNA binding site [nucleotide binding]; other site
592021012948	dimerization interface [polypeptide binding]; other site
592021012949	Protein of unknown function (DUF523); Region: DUF523; pfam04463
592021012950	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
592021012951	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
592021012952	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
592021012953	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
592021012954	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
592021012955	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
592021012956	hypothetical protein; Provisional; Region: PRK13669
592021012957	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
592021012958	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021012959	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
592021012960	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021012961	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021012962	Walker A/P-loop; other site
592021012963	ATP binding site [chemical binding]; other site
592021012964	Q-loop/lid; other site
592021012965	ABC transporter signature motif; other site
592021012966	Walker B; other site
592021012967	D-loop; other site
592021012968	H-loop/switch region; other site
592021012969	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
592021012970	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
592021012971	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
592021012972	PhnA protein; Region: PhnA; pfam03831
592021012973	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
592021012974	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
592021012975	PQQ-like domain; Region: PQQ_2; pfam13360
592021012976	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
592021012977	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
592021012978	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
592021012979	CAAX protease self-immunity; Region: Abi; pfam02517
592021012980	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
592021012981	active site
592021012982	NTP binding site [chemical binding]; other site
592021012983	metal binding triad [ion binding]; metal-binding site
592021012984	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
592021012985	Protein of unknown function (DUF1462); Region: DUF1462; pfam07315
592021012986	NifU-like domain; Region: NifU; pfam01106
592021012987	spore coat protein YutH; Region: spore_yutH; TIGR02905
592021012988	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
592021012989	tetramer interfaces [polypeptide binding]; other site
592021012990	binuclear metal-binding site [ion binding]; other site
592021012991	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
592021012992	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
592021012993	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
592021012994	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
592021012995	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021012996	active site
592021012997	motif I; other site
592021012998	motif II; other site
592021012999	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021013000	Predicted transcriptional regulator [Transcription]; Region: COG2345
592021013001	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021013002	putative Zn2+ binding site [ion binding]; other site
592021013003	putative DNA binding site [nucleotide binding]; other site
592021013004	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
592021013005	Uncharacterized conserved protein [Function unknown]; Region: COG2445
592021013006	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
592021013007	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
592021013008	putative active site [active]
592021013009	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
592021013010	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
592021013011	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
592021013012	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
592021013013	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021013014	DNA binding residues [nucleotide binding]
592021013015	dimer interface [polypeptide binding]; other site
592021013016	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
592021013017	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
592021013018	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
592021013019	catalytic core [active]
592021013020	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
592021013021	putative deacylase active site [active]
592021013022	lipoyl synthase; Provisional; Region: PRK05481
592021013023	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021013024	FeS/SAM binding site; other site
592021013025	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
592021013026	Peptidase family M23; Region: Peptidase_M23; pfam01551
592021013027	sporulation protein YunB; Region: spo_yunB; TIGR02832
592021013028	Uncharacterized conserved protein [Function unknown]; Region: COG3377
592021013029	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
592021013030	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
592021013031	active site
592021013032	metal binding site [ion binding]; metal-binding site
592021013033	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
592021013034	Predicted transcriptional regulators [Transcription]; Region: COG1695
592021013035	Transcriptional regulator PadR-like family; Region: PadR; cl17335
592021013036	VanZ like family; Region: VanZ; pfam04892
592021013037	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
592021013038	FeS assembly protein SufB; Region: sufB; TIGR01980
592021013039	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
592021013040	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
592021013041	trimerization site [polypeptide binding]; other site
592021013042	active site
592021013043	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
592021013044	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
592021013045	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
592021013046	catalytic residue [active]
592021013047	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
592021013048	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
592021013049	FeS assembly protein SufD; Region: sufD; TIGR01981
592021013050	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
592021013051	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
592021013052	Walker A/P-loop; other site
592021013053	ATP binding site [chemical binding]; other site
592021013054	Q-loop/lid; other site
592021013055	ABC transporter signature motif; other site
592021013056	Walker B; other site
592021013057	D-loop; other site
592021013058	H-loop/switch region; other site
592021013059	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
592021013060	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
592021013061	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
592021013062	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
592021013063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
592021013064	ABC-ATPase subunit interface; other site
592021013065	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
592021013066	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
592021013067	Walker A/P-loop; other site
592021013068	ATP binding site [chemical binding]; other site
592021013069	Q-loop/lid; other site
592021013070	ABC transporter signature motif; other site
592021013071	Walker B; other site
592021013072	D-loop; other site
592021013073	H-loop/switch region; other site
592021013074	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
592021013075	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
592021013076	catalytic residues [active]
592021013077	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
592021013078	putative active site [active]
592021013079	putative metal binding site [ion binding]; other site
592021013080	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
592021013081	lipoyl attachment site [posttranslational modification]; other site
592021013082	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
592021013083	ArsC family; Region: ArsC; pfam03960
592021013084	putative ArsC-like catalytic residues; other site
592021013085	putative TRX-like catalytic residues [active]
592021013086	Protein of unknown function (DUF3937); Region: DUF3937; pfam13073
592021013087	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
592021013088	active site
592021013089	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
592021013090	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
592021013091	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
592021013092	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
592021013093	tetramer (dimer of dimers) interface [polypeptide binding]; other site
592021013094	NAD binding site [chemical binding]; other site
592021013095	dimer interface [polypeptide binding]; other site
592021013096	substrate binding site [chemical binding]; other site
592021013097	Coat F domain; Region: Coat_F; pfam07875
592021013098	CAAX protease self-immunity; Region: Abi; pfam02517
592021013099	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021013100	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021013101	WHG domain; Region: WHG; pfam13305
592021013102	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
592021013103	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
592021013104	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
592021013105	active site
592021013106	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
592021013107	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
592021013108	dimer interface [polypeptide binding]; other site
592021013109	active site
592021013110	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
592021013111	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
592021013112	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
592021013113	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
592021013114	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
592021013115	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
592021013116	substrate binding site [chemical binding]; other site
592021013117	oxyanion hole (OAH) forming residues; other site
592021013118	YuzL-like protein; Region: YuzL; pfam14115
592021013119	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021013120	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
592021013121	Proline dehydrogenase; Region: Pro_dh; cl03282
592021013122	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
592021013123	Domain of unknown function DUF77; Region: DUF77; pfam01910
592021013124	Cache domain; Region: Cache_1; pfam02743
592021013125	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021013126	dimerization interface [polypeptide binding]; other site
592021013127	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021013128	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021013129	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021013130	dimer interface [polypeptide binding]; other site
592021013131	putative CheW interface [polypeptide binding]; other site
592021013132	Predicted transcriptional regulators [Transcription]; Region: COG1378
592021013133	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
592021013134	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
592021013135	C-terminal domain interface [polypeptide binding]; other site
592021013136	sugar binding site [chemical binding]; other site
592021013137	TQXA domain; Region: TQXA_dom; TIGR03934
592021013138	Cna protein B-type domain; Region: Cna_B; pfam05738
592021013139	Cna protein B-type domain; Region: Cna_B; pfam05738
592021013140	Cna protein B-type domain; Region: Cna_B; pfam05738
592021013141	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
592021013142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021013143	putative substrate translocation pore; other site
592021013144	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
592021013145	Spore germination protein; Region: Spore_permease; cl17796
592021013146	MAEBL; Provisional; Region: PTZ00121
592021013147	OxaA-like protein precursor; Validated; Region: PRK01622
592021013148	Uncharacterized conserved protein [Function unknown]; Region: COG1284
592021013149	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
592021013150	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
592021013151	hypothetical protein; Provisional; Region: PRK06758
592021013152	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
592021013153	active site
592021013154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021013155	non-specific DNA binding site [nucleotide binding]; other site
592021013156	salt bridge; other site
592021013157	sequence-specific DNA binding site [nucleotide binding]; other site
592021013158	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
592021013159	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
592021013160	Protein of unknown function (DUF3978); Region: DUF3978; pfam13123
592021013161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
592021013162	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
592021013163	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021013164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021013165	active site
592021013166	phosphorylation site [posttranslational modification]
592021013167	intermolecular recognition site; other site
592021013168	dimerization interface [polypeptide binding]; other site
592021013169	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021013170	DNA binding site [nucleotide binding]
592021013171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021013172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021013173	dimer interface [polypeptide binding]; other site
592021013174	phosphorylation site [posttranslational modification]
592021013175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021013176	ATP binding site [chemical binding]; other site
592021013177	Mg2+ binding site [ion binding]; other site
592021013178	G-X-G motif; other site
592021013179	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
592021013180	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
592021013181	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
592021013182	active site
592021013183	HIGH motif; other site
592021013184	KMSKS motif; other site
592021013185	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
592021013186	tRNA binding surface [nucleotide binding]; other site
592021013187	anticodon binding site; other site
592021013188	Methyltransferase domain; Region: Methyltransf_23; pfam13489
592021013189	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021013190	S-adenosylmethionine binding site [chemical binding]; other site
592021013191	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021013192	dimerization interface [polypeptide binding]; other site
592021013193	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021013194	dimer interface [polypeptide binding]; other site
592021013195	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021013196	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021013197	dimer interface [polypeptide binding]; other site
592021013198	putative CheW interface [polypeptide binding]; other site
592021013199	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
592021013200	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
592021013201	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
592021013202	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
592021013203	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
592021013204	active site
592021013205	Zn binding site [ion binding]; other site
592021013206	Pirin-related protein [General function prediction only]; Region: COG1741
592021013207	Pirin; Region: Pirin; pfam02678
592021013208	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
592021013209	MarR family; Region: MarR_2; pfam12802
592021013210	Protein of unknown function (DUF3920); Region: DUF3920; pfam13058
592021013211	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
592021013212	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
592021013213	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
592021013214	TrkA-C domain; Region: TrkA_C; pfam02080
592021013215	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
592021013216	amino acid carrier protein; Region: agcS; TIGR00835
592021013217	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
592021013218	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
592021013219	dimerization interface [polypeptide binding]; other site
592021013220	DPS ferroxidase diiron center [ion binding]; other site
592021013221	ion pore; other site
592021013222	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
592021013223	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
592021013224	metal binding site [ion binding]; metal-binding site
592021013225	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
592021013226	Ferritin-like domain; Region: Ferritin; pfam00210
592021013227	ferroxidase diiron center [ion binding]; other site
592021013228	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
592021013229	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
592021013230	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
592021013231	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
592021013232	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
592021013233	Nucleoside recognition; Region: Gate; pfam07670
592021013234	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
592021013235	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
592021013236	amino acid carrier protein; Region: agcS; TIGR00835
592021013237	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
592021013238	amino acid carrier protein; Region: agcS; TIGR00835
592021013239	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
592021013240	NADH(P)-binding; Region: NAD_binding_10; pfam13460
592021013241	NAD binding site [chemical binding]; other site
592021013242	substrate binding site [chemical binding]; other site
592021013243	putative active site [active]
592021013244	TQXA domain; Region: TQXA_dom; TIGR03934
592021013245	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
592021013246	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
592021013247	active site
592021013248	catalytic tetrad [active]
592021013249	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
592021013250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021013251	putative substrate translocation pore; other site
592021013252	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021013253	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021013254	dimerization interface [polypeptide binding]; other site
592021013255	putative DNA binding site [nucleotide binding]; other site
592021013256	putative Zn2+ binding site [ion binding]; other site
592021013257	Uncharacterized conserved protein [Function unknown]; Region: COG2427
592021013258	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
592021013259	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021013260	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
592021013261	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
592021013262	active site
592021013263	HIGH motif; other site
592021013264	dimer interface [polypeptide binding]; other site
592021013265	KMSKS motif; other site
592021013266	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
592021013267	RNA binding surface [nucleotide binding]; other site
592021013268	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436
592021013269	FAD binding domain; Region: FAD_binding_4; pfam01565
592021013270	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
592021013271	SET domain; Region: SET; pfam00856
592021013272	Domain of unknown function (DUF4077); Region: DUF4077; pfam13295
592021013273	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021013274	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021013275	dimer interface [polypeptide binding]; other site
592021013276	putative CheW interface [polypeptide binding]; other site
592021013277	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
592021013278	putative phosphate binding site [ion binding]; other site
592021013279	camphor resistance protein CrcB; Provisional; Region: PRK14219
592021013280	camphor resistance protein CrcB; Provisional; Region: PRK14205
592021013281	Protein of unknown function (DUF3947); Region: DUF3947; pfam13135
592021013282	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
592021013283	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
592021013284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
592021013285	Coenzyme A binding pocket [chemical binding]; other site
592021013286	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
592021013287	Nuclease-related domain; Region: NERD; pfam08378
592021013288	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
592021013289	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
592021013290	Walker A/P-loop; other site
592021013291	ATP binding site [chemical binding]; other site
592021013292	Q-loop/lid; other site
592021013293	ABC transporter signature motif; other site
592021013294	Walker B; other site
592021013295	D-loop; other site
592021013296	H-loop/switch region; other site
592021013297	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021013298	ABC-ATPase subunit  interface; other site
592021013299	dimer interface [polypeptide binding]; other site
592021013300	putative PBP binding regions; other site
592021013301	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
592021013302	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021013303	ABC-ATPase subunit  interface; other site
592021013304	dimer interface [polypeptide binding]; other site
592021013305	putative PBP binding regions; other site
592021013306	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
592021013307	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
592021013308	putative ligand binding residues [chemical binding]; other site
592021013309	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021013310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021013311	active site
592021013312	phosphorylation site [posttranslational modification]
592021013313	intermolecular recognition site; other site
592021013314	dimerization interface [polypeptide binding]; other site
592021013315	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021013316	DNA binding site [nucleotide binding]
592021013317	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
592021013318	SmpB-tmRNA interface; other site
592021013319	ribonuclease R; Region: RNase_R; TIGR02063
592021013320	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
592021013321	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
592021013322	RNB domain; Region: RNB; pfam00773
592021013323	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
592021013324	RNA binding site [nucleotide binding]; other site
592021013325	Esterase/lipase [General function prediction only]; Region: COG1647
592021013326	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
592021013327	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
592021013328	holin-like protein; Validated; Region: PRK01658
592021013329	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
592021013330	active site
592021013331	NUMOD4 motif; Region: NUMOD4; pfam07463
592021013332	HNH endonuclease; Region: HNH_3; pfam13392
592021013333	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
592021013334	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
592021013335	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
592021013336	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
592021013337	active site
592021013338	Phage-related protein [Function unknown]; Region: COG4695; cl01923
592021013339	Phage portal protein; Region: Phage_portal; pfam04860
592021013340	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
592021013341	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
592021013342	Phage capsid family; Region: Phage_capsid; pfam05065
592021013343	Phage capsid family; Region: Phage_capsid; pfam05065
592021013344	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
592021013345	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
592021013346	active site
592021013347	DNA binding site [nucleotide binding]
592021013348	Int/Topo IB signature motif; other site
592021013349	enolase; Provisional; Region: eno; PRK00077
592021013350	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
592021013351	dimer interface [polypeptide binding]; other site
592021013352	metal binding site [ion binding]; metal-binding site
592021013353	substrate binding pocket [chemical binding]; other site
592021013354	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
592021013355	phosphoglyceromutase; Provisional; Region: PRK05434
592021013356	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
592021013357	triosephosphate isomerase; Provisional; Region: PRK14565
592021013358	substrate binding site [chemical binding]; other site
592021013359	dimer interface [polypeptide binding]; other site
592021013360	catalytic triad [active]
592021013361	Phosphoglycerate kinase; Region: PGK; pfam00162
592021013362	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
592021013363	substrate binding site [chemical binding]; other site
592021013364	hinge regions; other site
592021013365	ADP binding site [chemical binding]; other site
592021013366	catalytic site [active]
592021013367	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
592021013368	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
592021013369	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
592021013370	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
592021013371	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
592021013372	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
592021013373	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
592021013374	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
592021013375	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
592021013376	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
592021013377	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
592021013378	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
592021013379	stage V sporulation protein AD; Provisional; Region: PRK12404
592021013380	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
592021013381	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
592021013382	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
592021013383	Predicted membrane protein [Function unknown]; Region: COG2323
592021013384	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
592021013385	Clp protease; Region: CLP_protease; pfam00574
592021013386	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
592021013387	oligomer interface [polypeptide binding]; other site
592021013388	active site residues [active]
592021013389	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
592021013390	dimerization domain swap beta strand [polypeptide binding]; other site
592021013391	regulatory protein interface [polypeptide binding]; other site
592021013392	active site
592021013393	regulatory phosphorylation site [posttranslational modification]; other site
592021013394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
592021013395	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
592021013396	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
592021013397	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
592021013398	phosphate binding site [ion binding]; other site
592021013399	putative substrate binding pocket [chemical binding]; other site
592021013400	dimer interface [polypeptide binding]; other site
592021013401	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
592021013402	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
592021013403	putative active site [active]
592021013404	nucleotide binding site [chemical binding]; other site
592021013405	nudix motif; other site
592021013406	putative metal binding site [ion binding]; other site
592021013407	Domain of unknown function (DUF368); Region: DUF368; pfam04018
592021013408	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
592021013409	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
592021013410	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
592021013411	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021013412	binding surface
592021013413	TPR motif; other site
592021013414	Tetratricopeptide repeat; Region: TPR_12; pfam13424
592021013415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
592021013416	binding surface
592021013417	Tetratricopeptide repeat; Region: TPR_16; pfam13432
592021013418	TPR motif; other site
592021013419	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
592021013420	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
592021013421	trimer interface [polypeptide binding]; other site
592021013422	active site
592021013423	substrate binding site [chemical binding]; other site
592021013424	CoA binding site [chemical binding]; other site
592021013425	pyrophosphatase PpaX; Provisional; Region: PRK13288
592021013426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021013427	active site
592021013428	motif I; other site
592021013429	motif II; other site
592021013430	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
592021013431	HPr kinase/phosphorylase; Provisional; Region: PRK05428
592021013432	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
592021013433	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
592021013434	Hpr binding site; other site
592021013435	active site
592021013436	homohexamer subunit interaction site [polypeptide binding]; other site
592021013437	Predicted membrane protein [Function unknown]; Region: COG1950
592021013438	Domain of unknown function (DUF4275); Region: DUF4275; pfam14101
592021013439	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
592021013440	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
592021013441	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
592021013442	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
592021013443	excinuclease ABC subunit B; Provisional; Region: PRK05298
592021013444	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021013445	ATP binding site [chemical binding]; other site
592021013446	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021013447	nucleotide binding region [chemical binding]; other site
592021013448	ATP-binding site [chemical binding]; other site
592021013449	Ultra-violet resistance protein B; Region: UvrB; pfam12344
592021013450	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
592021013451	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
592021013452	Probable transposase; Region: OrfB_IS605; pfam01385
592021013453	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
592021013454	Domain of unknown function (DUF4362); Region: DUF4362; pfam14275
592021013455	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
592021013456	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021013457	DNA binding residues [nucleotide binding]
592021013458	dimer interface [polypeptide binding]; other site
592021013459	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
592021013460	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021013461	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021013462	non-specific DNA binding site [nucleotide binding]; other site
592021013463	salt bridge; other site
592021013464	sequence-specific DNA binding site [nucleotide binding]; other site
592021013465	Predicted membrane protein [Function unknown]; Region: COG2855
592021013466	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021013467	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021013468	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
592021013469	putative dimerization interface [polypeptide binding]; other site
592021013470	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
592021013471	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
592021013472	DNA binding residues [nucleotide binding]
592021013473	putative dimer interface [polypeptide binding]; other site
592021013474	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
592021013475	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
592021013476	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
592021013477	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021013478	ABC transporter; Region: ABC_tran_2; pfam12848
592021013479	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021013480	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
592021013481	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
592021013482	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
592021013483	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
592021013484	Walker A/P-loop; other site
592021013485	ATP binding site [chemical binding]; other site
592021013486	Q-loop/lid; other site
592021013487	ABC transporter signature motif; other site
592021013488	Walker B; other site
592021013489	D-loop; other site
592021013490	H-loop/switch region; other site
592021013491	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
592021013492	protein binding site [polypeptide binding]; other site
592021013493	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
592021013494	C-terminal peptidase (prc); Region: prc; TIGR00225
592021013495	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
592021013496	protein binding site [polypeptide binding]; other site
592021013497	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
592021013498	Catalytic dyad [active]
592021013499	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
592021013500	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
592021013501	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
592021013502	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
592021013503	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
592021013504	Walker A/P-loop; other site
592021013505	ATP binding site [chemical binding]; other site
592021013506	Q-loop/lid; other site
592021013507	ABC transporter signature motif; other site
592021013508	Walker B; other site
592021013509	D-loop; other site
592021013510	H-loop/switch region; other site
592021013511	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
592021013512	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
592021013513	peptide chain release factor 2; Provisional; Region: PRK06746
592021013514	This domain is found in peptide chain release factors; Region: PCRF; smart00937
592021013515	RF-1 domain; Region: RF-1; pfam00472
592021013516	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
592021013517	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
592021013518	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
592021013519	nucleotide binding region [chemical binding]; other site
592021013520	ATP-binding site [chemical binding]; other site
592021013521	SEC-C motif; Region: SEC-C; pfam02810
592021013522	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
592021013523	30S subunit binding site; other site
592021013524	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
592021013525	DNA-binding site [nucleotide binding]; DNA binding site
592021013526	RNA-binding motif; other site
592021013527	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
592021013528	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021013529	active site
592021013530	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
592021013531	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021013532	ATP binding site [chemical binding]; other site
592021013533	putative Mg++ binding site [ion binding]; other site
592021013534	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021013535	nucleotide binding region [chemical binding]; other site
592021013536	ATP-binding site [chemical binding]; other site
592021013537	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
592021013538	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
592021013539	NlpC/P60 family; Region: NLPC_P60; pfam00877
592021013540	Predicted transcriptional regulators [Transcription]; Region: COG1733
592021013541	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
592021013542	dimerization interface [polypeptide binding]; other site
592021013543	putative DNA binding site [nucleotide binding]; other site
592021013544	putative Zn2+ binding site [ion binding]; other site
592021013545	EDD domain protein, DegV family; Region: DegV; TIGR00762
592021013546	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
592021013547	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
592021013548	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
592021013549	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
592021013550	Transcriptional regulator [Transcription]; Region: LytR; COG1316
592021013551	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
592021013552	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
592021013553	active site
592021013554	homodimer interface [polypeptide binding]; other site
592021013555	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
592021013556	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
592021013557	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
592021013558	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
592021013559	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
592021013560	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
592021013561	Mg++ binding site [ion binding]; other site
592021013562	putative catalytic motif [active]
592021013563	substrate binding site [chemical binding]; other site
592021013564	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
592021013565	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
592021013566	NodB motif; other site
592021013567	active site
592021013568	catalytic site [active]
592021013569	Zn binding site [ion binding]; other site
592021013570	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
592021013571	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
592021013572	Walker A motif; other site
592021013573	ATP binding site [chemical binding]; other site
592021013574	Walker B motif; other site
592021013575	arginine finger; other site
592021013576	Transcriptional antiterminator [Transcription]; Region: COG3933
592021013577	PRD domain; Region: PRD; pfam00874
592021013578	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
592021013579	active pocket/dimerization site; other site
592021013580	active site
592021013581	phosphorylation site [posttranslational modification]
592021013582	PRD domain; Region: PRD; pfam00874
592021013583	A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754
592021013584	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
592021013585	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
592021013586	Chromate transporter; Region: Chromate_transp; pfam02417
592021013587	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
592021013588	putative active site [active]
592021013589	YdjC motif; other site
592021013590	Mg binding site [ion binding]; other site
592021013591	putative homodimer interface [polypeptide binding]; other site
592021013592	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
592021013593	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
592021013594	NAD binding site [chemical binding]; other site
592021013595	sugar binding site [chemical binding]; other site
592021013596	divalent metal binding site [ion binding]; other site
592021013597	tetramer (dimer of dimers) interface [polypeptide binding]; other site
592021013598	dimer interface [polypeptide binding]; other site
592021013599	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
592021013600	active site
592021013601	methionine cluster; other site
592021013602	phosphorylation site [posttranslational modification]
592021013603	metal binding site [ion binding]; metal-binding site
592021013604	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
592021013605	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
592021013606	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
592021013607	active site
592021013608	P-loop; other site
592021013609	phosphorylation site [posttranslational modification]
592021013610	spermidine synthase; Provisional; Region: PRK03612
592021013611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021013612	S-adenosylmethionine binding site [chemical binding]; other site
592021013613	S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706
592021013614	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
592021013615	methionine cluster; other site
592021013616	active site
592021013617	phosphorylation site [posttranslational modification]
592021013618	metal binding site [ion binding]; metal-binding site
592021013619	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
592021013620	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
592021013621	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
592021013622	active site
592021013623	P-loop; other site
592021013624	phosphorylation site [posttranslational modification]
592021013625	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
592021013626	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
592021013627	Acyltransferase family; Region: Acyl_transf_3; pfam01757
592021013628	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
592021013629	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
592021013630	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
592021013631	Predicted membrane protein [Function unknown]; Region: COG1511
592021013632	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
592021013633	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
592021013634	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
592021013635	Transcriptional regulator [Transcription]; Region: LysR; COG0583
592021013636	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
592021013637	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
592021013638	putative dimerization interface [polypeptide binding]; other site
592021013639	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
592021013640	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
592021013641	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
592021013642	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
592021013643	transmembrane helices; other site
592021013644	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
592021013645	ThiC-associated domain; Region: ThiC-associated; pfam13667
592021013646	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
592021013647	L-lactate permease; Region: Lactate_perm; cl00701
592021013648	glycolate transporter; Provisional; Region: PRK09695
592021013649	Tic20-like protein; Region: Tic20; pfam09685
592021013650	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
592021013651	Uncharacterized conserved protein [Function unknown]; Region: COG3339
592021013652	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
592021013653	Sulfatase; Region: Sulfatase; pfam00884
592021013654	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
592021013655	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
592021013656	homodimer interface [polypeptide binding]; other site
592021013657	substrate-cofactor binding pocket; other site
592021013658	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021013659	catalytic residue [active]
592021013660	Bacterial SH3 domain; Region: SH3_3; cl17532
592021013661	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021013662	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021013663	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
592021013664	NlpC/P60 family; Region: NLPC_P60; pfam00877
592021013665	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
592021013666	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
592021013667	Nucleoside recognition; Region: Gate; pfam07670
592021013668	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
592021013669	BCCT family transporter; Region: BCCT; pfam02028
592021013670	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021013671	Bacterial SH3 domain; Region: SH3_3; pfam08239
592021013672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
592021013673	Protein of unknown function (DUF3910); Region: DUF3910; pfam13049
592021013674	Predicted membrane protein [Function unknown]; Region: COG4640
592021013675	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
592021013676	Double zinc ribbon; Region: DZR; pfam12773
592021013677	Double zinc ribbon; Region: DZR; pfam12773
592021013678	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
592021013679	SNF2 Helicase protein; Region: DUF3670; pfam12419
592021013680	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
592021013681	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
592021013682	ATP binding site [chemical binding]; other site
592021013683	putative Mg++ binding site [ion binding]; other site
592021013684	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
592021013685	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021013686	nucleotide binding region [chemical binding]; other site
592021013687	ATP-binding site [chemical binding]; other site
592021013688	Predicted integral membrane protein [Function unknown]; Region: COG5652
592021013689	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
592021013690	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
592021013691	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
592021013692	ComK protein; Region: ComK; pfam06338
592021013693	RNA polymerase factor sigma-70; Validated; Region: PRK06759
592021013694	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021013695	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021013696	DNA binding residues [nucleotide binding]
592021013697	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
592021013698	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
592021013699	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
592021013700	FtsX-like permease family; Region: FtsX; pfam02687
592021013701	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
592021013702	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
592021013703	Walker A/P-loop; other site
592021013704	ATP binding site [chemical binding]; other site
592021013705	Q-loop/lid; other site
592021013706	ABC transporter signature motif; other site
592021013707	Walker B; other site
592021013708	D-loop; other site
592021013709	H-loop/switch region; other site
592021013710	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
592021013711	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
592021013712	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
592021013713	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
592021013714	non-specific DNA binding site [nucleotide binding]; other site
592021013715	salt bridge; other site
592021013716	sequence-specific DNA binding site [nucleotide binding]; other site
592021013717	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
592021013718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021013719	putative substrate translocation pore; other site
592021013720	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
592021013721	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
592021013722	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
592021013723	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
592021013724	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
592021013725	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021013726	dimerization interface [polypeptide binding]; other site
592021013727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021013728	dimer interface [polypeptide binding]; other site
592021013729	phosphorylation site [posttranslational modification]
592021013730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021013731	ATP binding site [chemical binding]; other site
592021013732	Mg2+ binding site [ion binding]; other site
592021013733	G-X-G motif; other site
592021013734	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021013735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021013736	active site
592021013737	phosphorylation site [posttranslational modification]
592021013738	intermolecular recognition site; other site
592021013739	dimerization interface [polypeptide binding]; other site
592021013740	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021013741	DNA binding site [nucleotide binding]
592021013742	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
592021013743	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
592021013744	NAD binding site [chemical binding]; other site
592021013745	homodimer interface [polypeptide binding]; other site
592021013746	active site
592021013747	substrate binding site [chemical binding]; other site
592021013748	membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379
592021013749	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
592021013750	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
592021013751	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
592021013752	active site
592021013753	homodimer interface [polypeptide binding]; other site
592021013754	teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545
592021013755	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
592021013756	Walker A/P-loop; other site
592021013757	ATP binding site [chemical binding]; other site
592021013758	Q-loop/lid; other site
592021013759	ABC transporter signature motif; other site
592021013760	Walker B; other site
592021013761	D-loop; other site
592021013762	H-loop/switch region; other site
592021013763	Bacterial SH3 domain homologues; Region: SH3b; smart00287
592021013764	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
592021013765	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
592021013766	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
592021013767	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
592021013768	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
592021013769	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
592021013770	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
592021013771	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
592021013772	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
592021013773	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
592021013774	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
592021013775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
592021013776	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
592021013777	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
592021013778	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
592021013779	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
592021013780	putative glycosyl transferase; Provisional; Region: PRK10307
592021013781	rod shape-determining protein Mbl; Provisional; Region: PRK13928
592021013782	MreB and similar proteins; Region: MreB_like; cd10225
592021013783	nucleotide binding site [chemical binding]; other site
592021013784	Mg binding site [ion binding]; other site
592021013785	putative protofilament interaction site [polypeptide binding]; other site
592021013786	RodZ interaction site [polypeptide binding]; other site
592021013787	Stage III sporulation protein D; Region: SpoIIID; pfam12116
592021013788	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
592021013789	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
592021013790	Peptidase family M23; Region: Peptidase_M23; pfam01551
592021013791	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
592021013792	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
592021013793	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021013794	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021013795	Walker A/P-loop; other site
592021013796	ATP binding site [chemical binding]; other site
592021013797	Q-loop/lid; other site
592021013798	ABC transporter signature motif; other site
592021013799	Walker B; other site
592021013800	D-loop; other site
592021013801	H-loop/switch region; other site
592021013802	Stage II sporulation protein; Region: SpoIID; pfam08486
592021013803	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
592021013804	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
592021013805	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
592021013806	hinge; other site
592021013807	active site
592021013808	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
592021013809	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
592021013810	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
592021013811	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
592021013812	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
592021013813	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
592021013814	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
592021013815	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
592021013816	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
592021013817	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
592021013818	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
592021013819	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
592021013820	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
592021013821	4Fe-4S binding domain; Region: Fer4; cl02805
592021013822	4Fe-4S binding domain; Region: Fer4; pfam00037
592021013823	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
592021013824	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
592021013825	NADH dehydrogenase subunit D; Provisional; Region: PRK12322
592021013826	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
592021013827	NADH dehydrogenase subunit C; Validated; Region: PRK07735
592021013828	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
592021013829	NADH dehydrogenase subunit B; Validated; Region: PRK06411
592021013830	NADH dehydrogenase subunit A; Validated; Region: PRK07756
592021013831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021013832	PAS domain; Region: PAS_9; pfam13426
592021013833	putative active site [active]
592021013834	heme pocket [chemical binding]; other site
592021013835	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
592021013836	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021013837	metal binding site [ion binding]; metal-binding site
592021013838	active site
592021013839	I-site; other site
592021013840	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
592021013841	Protein of unknown function (DUF975); Region: DUF975; cl10504
592021013842	Protein of unknown function (DUF975); Region: DUF975; cl10504
592021013843	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
592021013844	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
592021013845	gamma subunit interface [polypeptide binding]; other site
592021013846	epsilon subunit interface [polypeptide binding]; other site
592021013847	LBP interface [polypeptide binding]; other site
592021013848	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
592021013849	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
592021013850	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
592021013851	alpha subunit interaction interface [polypeptide binding]; other site
592021013852	Walker A motif; other site
592021013853	ATP binding site [chemical binding]; other site
592021013854	Walker B motif; other site
592021013855	inhibitor binding site; inhibition site
592021013856	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
592021013857	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
592021013858	core domain interface [polypeptide binding]; other site
592021013859	delta subunit interface [polypeptide binding]; other site
592021013860	epsilon subunit interface [polypeptide binding]; other site
592021013861	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
592021013862	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
592021013863	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
592021013864	beta subunit interaction interface [polypeptide binding]; other site
592021013865	Walker A motif; other site
592021013866	ATP binding site [chemical binding]; other site
592021013867	Walker B motif; other site
592021013868	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
592021013869	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
592021013870	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
592021013871	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
592021013872	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
592021013873	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
592021013874	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
592021013875	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
592021013876	ATP synthase I chain; Region: ATP_synt_I; pfam03899
592021013877	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
592021013878	Protein of unknown function (DUF4024); Region: DUF4024; pfam13216
592021013879	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
592021013880	active site
592021013881	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
592021013882	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
592021013883	dimer interface [polypeptide binding]; other site
592021013884	active site
592021013885	glycine-pyridoxal phosphate binding site [chemical binding]; other site
592021013886	folate binding site [chemical binding]; other site
592021013887	hypothetical protein; Provisional; Region: PRK13690
592021013888	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
592021013889	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
592021013890	Low molecular weight phosphatase family; Region: LMWPc; cd00115
592021013891	active site
592021013892	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
592021013893	HPr interaction site; other site
592021013894	glycerol kinase (GK) interaction site [polypeptide binding]; other site
592021013895	active site
592021013896	phosphorylation site [posttranslational modification]
592021013897	Predicted membrane protein [Function unknown]; Region: COG2259
592021013898	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
592021013899	Protein of unknown function (DUF3935); Region: DUF3935; pfam13071
592021013900	Predicted membrane protein [Function unknown]; Region: COG1971
592021013901	Domain of unknown function DUF; Region: DUF204; pfam02659
592021013902	Domain of unknown function DUF; Region: DUF204; pfam02659
592021013903	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
592021013904	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
592021013905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
592021013906	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
592021013907	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
592021013908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021013909	S-adenosylmethionine binding site [chemical binding]; other site
592021013910	peptide chain release factor 1; Validated; Region: prfA; PRK00591
592021013911	This domain is found in peptide chain release factors; Region: PCRF; smart00937
592021013912	RF-1 domain; Region: RF-1; pfam00472
592021013913	thymidine kinase; Provisional; Region: PRK04296
592021013914	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
592021013915	transcription termination factor Rho; Provisional; Region: rho; PRK09376
592021013916	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
592021013917	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
592021013918	RNA binding site [nucleotide binding]; other site
592021013919	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
592021013920	multimer interface [polypeptide binding]; other site
592021013921	Walker A motif; other site
592021013922	ATP binding site [chemical binding]; other site
592021013923	Walker B motif; other site
592021013924	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
592021013925	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
592021013926	putative active site [active]
592021013927	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
592021013928	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
592021013929	hinge; other site
592021013930	active site
592021013931	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
592021013932	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
592021013933	intersubunit interface [polypeptide binding]; other site
592021013934	active site
592021013935	zinc binding site [ion binding]; other site
592021013936	Na+ binding site [ion binding]; other site
592021013937	Response regulator receiver domain; Region: Response_reg; pfam00072
592021013938	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021013939	active site
592021013940	phosphorylation site [posttranslational modification]
592021013941	intermolecular recognition site; other site
592021013942	dimerization interface [polypeptide binding]; other site
592021013943	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
592021013944	CTP synthetase; Validated; Region: pyrG; PRK05380
592021013945	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
592021013946	Catalytic site [active]
592021013947	active site
592021013948	UTP binding site [chemical binding]; other site
592021013949	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
592021013950	active site
592021013951	putative oxyanion hole; other site
592021013952	catalytic triad [active]
592021013953	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
592021013954	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021013955	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021013956	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
592021013957	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
592021013958	FAD binding site [chemical binding]; other site
592021013959	homotetramer interface [polypeptide binding]; other site
592021013960	substrate binding pocket [chemical binding]; other site
592021013961	catalytic base [active]
592021013962	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
592021013963	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
592021013964	FAD binding site [chemical binding]; other site
592021013965	homotetramer interface [polypeptide binding]; other site
592021013966	substrate binding pocket [chemical binding]; other site
592021013967	catalytic base [active]
592021013968	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
592021013969	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
592021013970	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
592021013971	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
592021013972	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
592021013973	dimer interface [polypeptide binding]; other site
592021013974	active site
592021013975	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
592021013976	4Fe-4S binding domain; Region: Fer4; cl02805
592021013977	Cysteine-rich domain; Region: CCG; pfam02754
592021013978	Cysteine-rich domain; Region: CCG; pfam02754
592021013979	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
592021013980	PLD-like domain; Region: PLDc_2; pfam13091
592021013981	putative active site [active]
592021013982	catalytic site [active]
592021013983	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
592021013984	PLD-like domain; Region: PLDc_2; pfam13091
592021013985	putative active site [active]
592021013986	catalytic site [active]
592021013987	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
592021013988	Domain of unknown function (DUF4084); Region: DUF4084; pfam13321
592021013989	PAS domain S-box; Region: sensory_box; TIGR00229
592021013990	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021013991	putative active site [active]
592021013992	heme pocket [chemical binding]; other site
592021013993	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
592021013994	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021013995	metal binding site [ion binding]; metal-binding site
592021013996	active site
592021013997	I-site; other site
592021013998	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
592021013999	Bacillus PapR protein; Region: Bacillus_PapR; pfam05968
592021014000	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
592021014001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021014002	active site
592021014003	phosphorylation site [posttranslational modification]
592021014004	intermolecular recognition site; other site
592021014005	dimerization interface [polypeptide binding]; other site
592021014006	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
592021014007	DNA binding residues [nucleotide binding]
592021014008	dimerization interface [polypeptide binding]; other site
592021014009	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
592021014010	Histidine kinase; Region: HisKA_3; pfam07730
592021014011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021014012	ATP binding site [chemical binding]; other site
592021014013	Mg2+ binding site [ion binding]; other site
592021014014	G-X-G motif; other site
592021014015	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
592021014016	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
592021014017	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021014018	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
592021014019	Walker A/P-loop; other site
592021014020	ATP binding site [chemical binding]; other site
592021014021	Q-loop/lid; other site
592021014022	ABC transporter signature motif; other site
592021014023	Walker B; other site
592021014024	D-loop; other site
592021014025	H-loop/switch region; other site
592021014026	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
592021014027	active site
592021014028	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
592021014029	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
592021014030	PA/protease or protease-like domain interface [polypeptide binding]; other site
592021014031	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
592021014032	Peptidase family M28; Region: Peptidase_M28; pfam04389
592021014033	metal binding site [ion binding]; metal-binding site
592021014034	RNA polymerase sigma factor; Provisional; Region: PRK12522
592021014035	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
592021014036	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
592021014037	DNA binding residues [nucleotide binding]
592021014038	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
592021014039	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
592021014040	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
592021014041	active site
592021014042	HIGH motif; other site
592021014043	KMSK motif region; other site
592021014044	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
592021014045	tRNA binding surface [nucleotide binding]; other site
592021014046	anticodon binding site; other site
592021014047	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
592021014048	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
592021014049	putative dimer interface [polypeptide binding]; other site
592021014050	catalytic triad [active]
592021014051	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
592021014052	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
592021014053	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
592021014054	agmatinase; Region: agmatinase; TIGR01230
592021014055	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
592021014056	putative active site [active]
592021014057	Mn binding site [ion binding]; other site
592021014058	spermidine synthase; Provisional; Region: PRK00811
592021014059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021014060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021014061	Major Facilitator Superfamily; Region: MFS_1; pfam07690
592021014062	putative substrate translocation pore; other site
592021014063	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
592021014064	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
592021014065	DNA binding residues [nucleotide binding]
592021014066	putative dimer interface [polypeptide binding]; other site
592021014067	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
592021014068	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
592021014069	active site
592021014070	catalytic site [active]
592021014071	metal binding site [ion binding]; metal-binding site
592021014072	dimer interface [polypeptide binding]; other site
592021014073	Transglycosylase; Region: Transgly; pfam00912
592021014074	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
592021014075	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
592021014076	YwhD family; Region: YwhD; pfam08741
592021014077	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
592021014078	Peptidase family M50; Region: Peptidase_M50; pfam02163
592021014079	active site
592021014080	putative substrate binding region [chemical binding]; other site
592021014081	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
592021014082	active site 1 [active]
592021014083	dimer interface [polypeptide binding]; other site
592021014084	hexamer interface [polypeptide binding]; other site
592021014085	active site 2 [active]
592021014086	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
592021014087	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
592021014088	Zn2+ binding site [ion binding]; other site
592021014089	Mg2+ binding site [ion binding]; other site
592021014090	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
592021014091	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
592021014092	intersubunit interface [polypeptide binding]; other site
592021014093	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
592021014094	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
592021014095	Walker A/P-loop; other site
592021014096	ATP binding site [chemical binding]; other site
592021014097	Q-loop/lid; other site
592021014098	ABC transporter signature motif; other site
592021014099	Walker B; other site
592021014100	D-loop; other site
592021014101	H-loop/switch region; other site
592021014102	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
592021014103	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
592021014104	ABC-ATPase subunit  interface; other site
592021014105	dimer interface [polypeptide binding]; other site
592021014106	putative PBP binding regions; other site
592021014107	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
592021014108	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
592021014109	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
592021014110	hypothetical protein; Provisional; Region: PRK12473
592021014111	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
592021014112	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
592021014113	putative heme peroxidase; Provisional; Region: PRK12276
592021014114	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
592021014115	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
592021014116	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
592021014117	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
592021014118	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
592021014119	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
592021014120	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
592021014121	putative uracil/xanthine transporter; Provisional; Region: PRK11412
592021014122	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
592021014123	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021014124	motif II; other site
592021014125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021014126	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
592021014127	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
592021014128	ligand binding site [chemical binding]; other site
592021014129	active site
592021014130	UGI interface [polypeptide binding]; other site
592021014131	catalytic site [active]
592021014132	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
592021014133	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
592021014134	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
592021014135	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
592021014136	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
592021014137	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
592021014138	Walker A/P-loop; other site
592021014139	ATP binding site [chemical binding]; other site
592021014140	Q-loop/lid; other site
592021014141	ABC transporter signature motif; other site
592021014142	Walker B; other site
592021014143	D-loop; other site
592021014144	H-loop/switch region; other site
592021014145	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
592021014146	active site
592021014147	catalytic triad [active]
592021014148	oxyanion hole [active]
592021014149	Transcriptional regulators [Transcription]; Region: PurR; COG1609
592021014150	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
592021014151	DNA binding site [nucleotide binding]
592021014152	domain linker motif; other site
592021014153	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
592021014154	putative dimerization interface [polypeptide binding]; other site
592021014155	putative ligand binding site [chemical binding]; other site
592021014156	Predicted membrane protein [Function unknown]; Region: COG2364
592021014157	homoserine dehydrogenase; Provisional; Region: PRK06349
592021014158	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
592021014159	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
592021014160	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
592021014161	homoserine O-succinyltransferase; Provisional; Region: PRK05368
592021014162	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
592021014163	proposed active site lysine [active]
592021014164	conserved cys residue [active]
592021014165	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702
592021014166	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
592021014167	homodimer interface [polypeptide binding]; other site
592021014168	substrate-cofactor binding pocket; other site
592021014169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
592021014170	catalytic residue [active]
592021014171	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
592021014172	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
592021014173	Cl- selectivity filter; other site
592021014174	Cl- binding residues [ion binding]; other site
592021014175	pore gating glutamate residue; other site
592021014176	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
592021014177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
592021014178	active site
592021014179	motif I; other site
592021014180	motif II; other site
592021014181	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
592021014182	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
592021014183	ligand binding site [chemical binding]; other site
592021014184	flexible hinge region; other site
592021014185	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
592021014186	azoreductase; Provisional; Region: PRK13556
592021014187	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
592021014188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021014189	active site
592021014190	phosphorylation site [posttranslational modification]
592021014191	intermolecular recognition site; other site
592021014192	dimerization interface [polypeptide binding]; other site
592021014193	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
592021014194	DNA binding residues [nucleotide binding]
592021014195	dimerization interface [polypeptide binding]; other site
592021014196	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
592021014197	dimer interface [polypeptide binding]; other site
592021014198	substrate binding site [chemical binding]; other site
592021014199	ATP binding site [chemical binding]; other site
592021014200	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
592021014201	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
592021014202	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
592021014203	metal binding site [ion binding]; metal-binding site
592021014204	active site
592021014205	I-site; other site
592021014206	Protein of unknown function (DUF466); Region: DUF466; pfam04328
592021014207	carbon starvation protein A; Provisional; Region: PRK15015
592021014208	Carbon starvation protein CstA; Region: CstA; pfam02554
592021014209	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
592021014210	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
592021014211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021014212	active site
592021014213	phosphorylation site [posttranslational modification]
592021014214	intermolecular recognition site; other site
592021014215	dimerization interface [polypeptide binding]; other site
592021014216	LytTr DNA-binding domain; Region: LytTR; pfam04397
592021014217	benzoate transport; Region: 2A0115; TIGR00895
592021014218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021014219	putative substrate translocation pore; other site
592021014220	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
592021014221	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
592021014222	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
592021014223	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
592021014224	Predicted membrane protein [Function unknown]; Region: COG2860
592021014225	UPF0126 domain; Region: UPF0126; pfam03458
592021014226	UPF0126 domain; Region: UPF0126; pfam03458
592021014227	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
592021014228	heme-binding site [chemical binding]; other site
592021014229	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
592021014230	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
592021014231	dimer interface [polypeptide binding]; other site
592021014232	putative CheW interface [polypeptide binding]; other site
592021014233	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
592021014234	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
592021014235	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
592021014236	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
592021014237	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
592021014238	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
592021014239	active site
592021014240	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
592021014241	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021014242	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021014243	ABC transporter; Region: ABC_tran_2; pfam12848
592021014244	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
592021014245	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
592021014246	Predicted membrane protein [Function unknown]; Region: COG2246
592021014247	GtrA-like protein; Region: GtrA; pfam04138
592021014248	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
592021014249	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
592021014250	Ligand binding site; other site
592021014251	Putative Catalytic site; other site
592021014252	DXD motif; other site
592021014253	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
592021014254	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
592021014255	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
592021014256	Protein export membrane protein; Region: SecD_SecF; cl14618
592021014257	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
592021014258	methionine sulfoxide reductase B; Provisional; Region: PRK00222
592021014259	SelR domain; Region: SelR; pfam01641
592021014260	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
592021014261	antiholin-like protein LrgB; Provisional; Region: PRK04288
592021014262	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
592021014263	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
592021014264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021014265	active site
592021014266	phosphorylation site [posttranslational modification]
592021014267	intermolecular recognition site; other site
592021014268	dimerization interface [polypeptide binding]; other site
592021014269	LytTr DNA-binding domain; Region: LytTR; pfam04397
592021014270	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
592021014271	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
592021014272	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
592021014273	Histidine kinase; Region: His_kinase; pfam06580
592021014274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021014275	ATP binding site [chemical binding]; other site
592021014276	Mg2+ binding site [ion binding]; other site
592021014277	G-X-G motif; other site
592021014278	benzoate transport; Region: 2A0115; TIGR00895
592021014279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
592021014280	putative substrate translocation pore; other site
592021014281	BCCT family transporter; Region: BCCT; pfam02028
592021014282	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
592021014283	active site
592021014284	dimer interface [polypeptide binding]; other site
592021014285	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
592021014286	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
592021014287	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
592021014288	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
592021014289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
592021014290	NAD(P) binding site [chemical binding]; other site
592021014291	active site
592021014292	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
592021014293	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
592021014294	UDP-glucose 4-epimerase; Region: PLN02240
592021014295	NAD binding site [chemical binding]; other site
592021014296	homodimer interface [polypeptide binding]; other site
592021014297	active site
592021014298	substrate binding site [chemical binding]; other site
592021014299	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
592021014300	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
592021014301	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
592021014302	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
592021014303	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
592021014304	ATP binding site [chemical binding]; other site
592021014305	Mg++ binding site [ion binding]; other site
592021014306	motif III; other site
592021014307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
592021014308	nucleotide binding region [chemical binding]; other site
592021014309	ATP-binding site [chemical binding]; other site
592021014310	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
592021014311	RNA binding site [nucleotide binding]; other site
592021014312	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
592021014313	Acyltransferase family; Region: Acyl_transf_3; pfam01757
592021014314	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
592021014315	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
592021014316	active site
592021014317	oligoendopeptidase F; Region: pepF; TIGR00181
592021014318	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
592021014319	active site
592021014320	Zn binding site [ion binding]; other site
592021014321	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
592021014322	FeS/SAM binding site; other site
592021014323	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
592021014324	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
592021014325	CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129
592021014326	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
592021014327	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
592021014328	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
592021014329	protein binding site [polypeptide binding]; other site
592021014330	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
592021014331	YycH protein; Region: YycI; pfam09648
592021014332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
592021014333	YycH protein; Region: YycH; pfam07435
592021014334	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
592021014335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
592021014336	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
592021014337	dimerization interface [polypeptide binding]; other site
592021014338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
592021014339	putative active site [active]
592021014340	heme pocket [chemical binding]; other site
592021014341	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
592021014342	dimer interface [polypeptide binding]; other site
592021014343	phosphorylation site [posttranslational modification]
592021014344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
592021014345	ATP binding site [chemical binding]; other site
592021014346	Mg2+ binding site [ion binding]; other site
592021014347	G-X-G motif; other site
592021014348	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
592021014349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
592021014350	active site
592021014351	phosphorylation site [posttranslational modification]
592021014352	intermolecular recognition site; other site
592021014353	dimerization interface [polypeptide binding]; other site
592021014354	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
592021014355	DNA binding site [nucleotide binding]
592021014356	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
592021014357	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
592021014358	GDP-binding site [chemical binding]; other site
592021014359	ACT binding site; other site
592021014360	IMP binding site; other site
592021014361	replicative DNA helicase; Provisional; Region: PRK05748
592021014362	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
592021014363	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
592021014364	Walker A motif; other site
592021014365	ATP binding site [chemical binding]; other site
592021014366	Walker B motif; other site
592021014367	DNA binding loops [nucleotide binding]
592021014368	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
592021014369	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
592021014370	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
592021014371	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
592021014372	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
592021014373	DHH family; Region: DHH; pfam01368
592021014374	DHHA1 domain; Region: DHHA1; pfam02272
592021014375	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
592021014376	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
592021014377	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
592021014378	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
592021014379	dimer interface [polypeptide binding]; other site
592021014380	ssDNA binding site [nucleotide binding]; other site
592021014381	tetramer (dimer of dimers) interface [polypeptide binding]; other site
592021014382	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
592021014383	GTP-binding protein YchF; Reviewed; Region: PRK09601
592021014384	YchF GTPase; Region: YchF; cd01900
592021014385	G1 box; other site
592021014386	GTP/Mg2+ binding site [chemical binding]; other site
592021014387	Switch I region; other site
592021014388	G2 box; other site
592021014389	Switch II region; other site
592021014390	G3 box; other site
592021014391	G4 box; other site
592021014392	G5 box; other site
592021014393	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
592021014394	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
592021014395	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
592021014396	Mechanosensitive ion channel; Region: MS_channel; pfam00924
592021014397	putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841
592021014398	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
592021014399	ParB-like nuclease domain; Region: ParB; smart00470
592021014400	KorB domain; Region: KorB; pfam08535
592021014401	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
592021014402	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
592021014403	P-loop; other site
592021014404	Magnesium ion binding site [ion binding]; other site
592021014405	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
592021014406	Magnesium ion binding site [ion binding]; other site
592021014407	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
592021014408	ParB-like nuclease domain; Region: ParBc; pfam02195
592021014409	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
592021014410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
592021014411	S-adenosylmethionine binding site [chemical binding]; other site
592021014412	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
592021014413	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
592021014414	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
592021014415	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
592021014416	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
592021014417	trmE is a tRNA modification GTPase; Region: trmE; cd04164
592021014418	G1 box; other site
592021014419	GTP/Mg2+ binding site [chemical binding]; other site
592021014420	Switch I region; other site
592021014421	G2 box; other site
592021014422	Switch II region; other site
592021014423	G3 box; other site
592021014424	G4 box; other site
592021014425	G5 box; other site
592021014426	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
592021014427	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
592021014428	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
592021014429	G-X-X-G motif; other site
592021014430	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
592021014431	RxxxH motif; other site
592021014432	OxaA-like protein precursor; Validated; Region: PRK02944
592021014433	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
592021014434	ribonuclease P; Reviewed; Region: rnpA; PRK00499
592021014435	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399