-- dump date 20140618_212153 -- class Genbank::misc_feature -- table misc_feature_note -- id note 198094000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 198094000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 198094000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094000004 Walker A motif; other site 198094000005 ATP binding site [chemical binding]; other site 198094000006 Walker B motif; other site 198094000007 arginine finger; other site 198094000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 198094000009 DnaA box-binding interface [nucleotide binding]; other site 198094000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 198094000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 198094000012 putative DNA binding surface [nucleotide binding]; other site 198094000013 dimer interface [polypeptide binding]; other site 198094000014 beta-clamp/clamp loader binding surface; other site 198094000015 beta-clamp/translesion DNA polymerase binding surface; other site 198094000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 198094000017 recombination protein F; Reviewed; Region: recF; PRK00064 198094000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 198094000019 Walker A/P-loop; other site 198094000020 ATP binding site [chemical binding]; other site 198094000021 Q-loop/lid; other site 198094000022 ABC transporter signature motif; other site 198094000023 Walker B; other site 198094000024 D-loop; other site 198094000025 H-loop/switch region; other site 198094000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 198094000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094000028 ATP binding site [chemical binding]; other site 198094000029 Mg2+ binding site [ion binding]; other site 198094000030 G-X-G motif; other site 198094000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 198094000032 anchoring element; other site 198094000033 dimer interface [polypeptide binding]; other site 198094000034 ATP binding site [chemical binding]; other site 198094000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 198094000036 active site 198094000037 putative metal-binding site [ion binding]; other site 198094000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 198094000039 DNA gyrase subunit A; Validated; Region: PRK05560 198094000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 198094000041 CAP-like domain; other site 198094000042 active site 198094000043 primary dimer interface [polypeptide binding]; other site 198094000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094000050 YaaC-like Protein; Region: YaaC; pfam14175 198094000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 198094000052 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 198094000053 active site 198094000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 198094000055 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198094000056 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 198094000057 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 198094000058 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 198094000059 active site 198094000060 multimer interface [polypeptide binding]; other site 198094000061 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 198094000062 predicted active site [active] 198094000063 catalytic triad [active] 198094000064 seryl-tRNA synthetase; Provisional; Region: PRK05431 198094000065 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 198094000066 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 198094000067 dimer interface [polypeptide binding]; other site 198094000068 active site 198094000069 motif 1; other site 198094000070 motif 2; other site 198094000071 motif 3; other site 198094000072 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 198094000073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 198094000074 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 198094000075 DNA binding residues [nucleotide binding] 198094000076 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 198094000077 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 198094000078 Substrate-binding site [chemical binding]; other site 198094000079 Substrate specificity [chemical binding]; other site 198094000080 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 198094000081 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 198094000082 Substrate-binding site [chemical binding]; other site 198094000083 Substrate specificity [chemical binding]; other site 198094000084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 198094000085 catalytic triad [active] 198094000086 conserved cis-peptide bond; other site 198094000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 198094000088 nucleoside/Zn binding site; other site 198094000089 dimer interface [polypeptide binding]; other site 198094000090 catalytic motif [active] 198094000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 198094000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094000093 Walker A motif; other site 198094000094 ATP binding site [chemical binding]; other site 198094000095 Walker B motif; other site 198094000096 arginine finger; other site 198094000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 198094000098 hypothetical protein; Validated; Region: PRK00153 198094000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 198094000100 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 198094000101 RecR protein; Region: RecR; pfam02132 198094000102 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 198094000103 putative active site [active] 198094000104 putative metal-binding site [ion binding]; other site 198094000105 tetramer interface [polypeptide binding]; other site 198094000106 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 198094000107 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 198094000108 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 198094000109 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 198094000110 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198094000111 homodimer interface [polypeptide binding]; other site 198094000112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094000113 catalytic residue [active] 198094000114 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198094000115 thymidylate kinase; Validated; Region: tmk; PRK00698 198094000116 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 198094000117 TMP-binding site; other site 198094000118 ATP-binding site [chemical binding]; other site 198094000119 DNA polymerase III subunit delta'; Validated; Region: PRK08058 198094000120 DNA polymerase III subunit delta'; Validated; Region: PRK08485 198094000121 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 198094000122 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 198094000123 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 198094000124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094000125 S-adenosylmethionine binding site [chemical binding]; other site 198094000126 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 198094000127 GIY-YIG motif/motif A; other site 198094000128 putative active site [active] 198094000129 putative metal binding site [ion binding]; other site 198094000130 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 198094000131 putative SAM binding site [chemical binding]; other site 198094000132 putative homodimer interface [polypeptide binding]; other site 198094000133 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 198094000134 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 198094000135 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 198094000136 active site 198094000137 HIGH motif; other site 198094000138 KMSKS motif; other site 198094000139 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 198094000140 tRNA binding surface [nucleotide binding]; other site 198094000141 anticodon binding site; other site 198094000142 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 198094000143 dimer interface [polypeptide binding]; other site 198094000144 putative tRNA-binding site [nucleotide binding]; other site 198094000145 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 198094000146 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198094000147 active site 198094000148 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 198094000149 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 198094000150 putative active site [active] 198094000151 putative metal binding site [ion binding]; other site 198094000152 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 198094000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094000154 S-adenosylmethionine binding site [chemical binding]; other site 198094000155 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 198094000156 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 198094000157 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 198094000158 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 198094000159 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198094000160 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 198094000161 pur operon repressor; Provisional; Region: PRK09213 198094000162 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 198094000163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094000164 active site 198094000165 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198094000166 homotrimer interaction site [polypeptide binding]; other site 198094000167 putative active site [active] 198094000168 regulatory protein SpoVG; Reviewed; Region: PRK13259 198094000169 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 198094000170 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 198094000171 Substrate binding site; other site 198094000172 Mg++ binding site; other site 198094000173 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 198094000174 active site 198094000175 substrate binding site [chemical binding]; other site 198094000176 CoA binding site [chemical binding]; other site 198094000177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 198094000178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 198094000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094000180 active site 198094000181 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 198094000182 putative active site [active] 198094000183 catalytic residue [active] 198094000184 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 198094000185 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 198094000186 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 198094000187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094000188 ATP binding site [chemical binding]; other site 198094000189 putative Mg++ binding site [ion binding]; other site 198094000190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094000191 nucleotide binding region [chemical binding]; other site 198094000192 ATP-binding site [chemical binding]; other site 198094000193 TRCF domain; Region: TRCF; pfam03461 198094000194 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 198094000195 stage V sporulation protein T; Region: spore_V_T; TIGR02851 198094000196 stage V sporulation protein B; Region: spore_V_B; TIGR02900 198094000197 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 198094000198 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 198094000199 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 198094000200 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 198094000201 putative SAM binding site [chemical binding]; other site 198094000202 putative homodimer interface [polypeptide binding]; other site 198094000203 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 198094000204 homodimer interface [polypeptide binding]; other site 198094000205 metal binding site [ion binding]; metal-binding site 198094000206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 198094000207 homodimer interface [polypeptide binding]; other site 198094000208 active site 198094000209 putative chemical substrate binding site [chemical binding]; other site 198094000210 metal binding site [ion binding]; metal-binding site 198094000211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094000212 RNA binding surface [nucleotide binding]; other site 198094000213 sporulation protein YabP; Region: spore_yabP; TIGR02892 198094000214 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 198094000215 Septum formation initiator; Region: DivIC; pfam04977 198094000216 hypothetical protein; Provisional; Region: PRK08582 198094000217 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 198094000218 RNA binding site [nucleotide binding]; other site 198094000219 stage II sporulation protein E; Region: spore_II_E; TIGR02865 198094000220 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 198094000221 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 198094000222 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 198094000223 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 198094000224 Ligand Binding Site [chemical binding]; other site 198094000225 TilS substrate binding domain; Region: TilS; pfam09179 198094000226 TilS substrate C-terminal domain; Region: TilS_C; smart00977 198094000227 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094000228 active site 198094000229 FtsH Extracellular; Region: FtsH_ext; pfam06480 198094000230 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 198094000231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094000232 Walker A motif; other site 198094000233 ATP binding site [chemical binding]; other site 198094000234 Walker B motif; other site 198094000235 arginine finger; other site 198094000236 Peptidase family M41; Region: Peptidase_M41; pfam01434 198094000237 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198094000238 nucleotide binding site [chemical binding]; other site 198094000239 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 198094000240 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 198094000241 dimerization interface [polypeptide binding]; other site 198094000242 domain crossover interface; other site 198094000243 redox-dependent activation switch; other site 198094000244 cysteine synthase; Region: PLN02565 198094000245 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198094000246 dimer interface [polypeptide binding]; other site 198094000247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094000248 catalytic residue [active] 198094000249 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 198094000250 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 198094000251 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 198094000252 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 198094000253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 198094000254 glutamine binding [chemical binding]; other site 198094000255 catalytic triad [active] 198094000256 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 198094000257 homodimer interface [polypeptide binding]; other site 198094000258 substrate-cofactor binding pocket; other site 198094000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094000260 catalytic residue [active] 198094000261 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 198094000262 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 198094000263 substrate binding pocket [chemical binding]; other site 198094000264 dimer interface [polypeptide binding]; other site 198094000265 inhibitor binding site; inhibition site 198094000266 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 198094000267 homooctamer interface [polypeptide binding]; other site 198094000268 active site 198094000269 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 198094000270 catalytic center binding site [active] 198094000271 ATP binding site [chemical binding]; other site 198094000272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094000273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094000274 non-specific DNA binding site [nucleotide binding]; other site 198094000275 salt bridge; other site 198094000276 sequence-specific DNA binding site [nucleotide binding]; other site 198094000277 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 198094000278 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198094000279 FMN binding site [chemical binding]; other site 198094000280 active site 198094000281 catalytic residues [active] 198094000282 substrate binding site [chemical binding]; other site 198094000283 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 198094000284 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 198094000285 dimer interface [polypeptide binding]; other site 198094000286 putative anticodon binding site; other site 198094000287 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 198094000288 motif 1; other site 198094000289 active site 198094000290 motif 2; other site 198094000291 motif 3; other site 198094000292 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 198094000293 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 198094000294 UvrB/uvrC motif; Region: UVR; pfam02151 198094000295 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 198094000296 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 198094000297 ADP binding site [chemical binding]; other site 198094000298 phosphagen binding site; other site 198094000299 substrate specificity loop; other site 198094000300 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 198094000301 Clp amino terminal domain; Region: Clp_N; pfam02861 198094000302 Clp amino terminal domain; Region: Clp_N; pfam02861 198094000303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094000304 Walker A motif; other site 198094000305 ATP binding site [chemical binding]; other site 198094000306 Walker B motif; other site 198094000307 arginine finger; other site 198094000308 UvrB/uvrC motif; Region: UVR; pfam02151 198094000309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094000310 Walker A motif; other site 198094000311 ATP binding site [chemical binding]; other site 198094000312 Walker B motif; other site 198094000313 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198094000314 DNA repair protein RadA; Provisional; Region: PRK11823 198094000315 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 198094000316 Walker A motif/ATP binding site; other site 198094000317 ATP binding site [chemical binding]; other site 198094000318 Walker B motif; other site 198094000319 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 198094000320 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 198094000321 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 198094000322 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 198094000323 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 198094000324 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 198094000325 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 198094000326 putative active site [active] 198094000327 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 198094000328 substrate binding site; other site 198094000329 dimer interface; other site 198094000330 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 198094000331 homotrimer interaction site [polypeptide binding]; other site 198094000332 zinc binding site [ion binding]; other site 198094000333 CDP-binding sites; other site 198094000334 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 198094000335 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 198094000336 active site 198094000337 HIGH motif; other site 198094000338 KMSKS motif; other site 198094000339 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 198094000340 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 198094000341 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 198094000342 trimer interface [polypeptide binding]; other site 198094000343 active site 198094000344 substrate binding site [chemical binding]; other site 198094000345 CoA binding site [chemical binding]; other site 198094000346 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 198094000347 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 198094000348 active site 198094000349 HIGH motif; other site 198094000350 KMSKS motif; other site 198094000351 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 198094000352 tRNA binding surface [nucleotide binding]; other site 198094000353 anticodon binding site; other site 198094000354 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 198094000355 active site 198094000356 metal binding site [ion binding]; metal-binding site 198094000357 dimerization interface [polypeptide binding]; other site 198094000358 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 198094000359 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 198094000360 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198094000361 YacP-like NYN domain; Region: NYN_YacP; pfam05991 198094000362 RNA polymerase factor sigma-70; Validated; Region: PRK08295 198094000363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094000364 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 198094000365 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 198094000366 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 198094000367 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 198094000368 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 198094000369 putative homodimer interface [polypeptide binding]; other site 198094000370 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 198094000371 heterodimer interface [polypeptide binding]; other site 198094000372 homodimer interface [polypeptide binding]; other site 198094000373 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 198094000374 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 198094000375 23S rRNA interface [nucleotide binding]; other site 198094000376 L7/L12 interface [polypeptide binding]; other site 198094000377 putative thiostrepton binding site; other site 198094000378 L25 interface [polypeptide binding]; other site 198094000379 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 198094000380 mRNA/rRNA interface [nucleotide binding]; other site 198094000381 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 198094000382 23S rRNA interface [nucleotide binding]; other site 198094000383 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 198094000384 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 198094000385 core dimer interface [polypeptide binding]; other site 198094000386 peripheral dimer interface [polypeptide binding]; other site 198094000387 L10 interface [polypeptide binding]; other site 198094000388 L11 interface [polypeptide binding]; other site 198094000389 putative EF-Tu interaction site [polypeptide binding]; other site 198094000390 putative EF-G interaction site [polypeptide binding]; other site 198094000391 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 198094000392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094000393 S-adenosylmethionine binding site [chemical binding]; other site 198094000394 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 198094000395 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 198094000396 RPB12 interaction site [polypeptide binding]; other site 198094000397 RPB1 interaction site [polypeptide binding]; other site 198094000398 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 198094000399 RPB10 interaction site [polypeptide binding]; other site 198094000400 RPB11 interaction site [polypeptide binding]; other site 198094000401 RPB3 interaction site [polypeptide binding]; other site 198094000402 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 198094000403 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 198094000404 beta and beta' interface [polypeptide binding]; other site 198094000405 beta' and sigma factor interface [polypeptide binding]; other site 198094000406 Zn-binding [ion binding]; other site 198094000407 active site region [active] 198094000408 catalytic site [active] 198094000409 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 198094000410 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 198094000411 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 198094000412 G-loop; other site 198094000413 DNA binding site [nucleotide binding] 198094000414 hypothetical protein; Provisional; Region: PRK06683 198094000415 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 198094000416 S17 interaction site [polypeptide binding]; other site 198094000417 S8 interaction site; other site 198094000418 16S rRNA interaction site [nucleotide binding]; other site 198094000419 streptomycin interaction site [chemical binding]; other site 198094000420 23S rRNA interaction site [nucleotide binding]; other site 198094000421 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 198094000422 30S ribosomal protein S7; Validated; Region: PRK05302 198094000423 elongation factor G; Reviewed; Region: PRK00007 198094000424 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 198094000425 G1 box; other site 198094000426 putative GEF interaction site [polypeptide binding]; other site 198094000427 GTP/Mg2+ binding site [chemical binding]; other site 198094000428 Switch I region; other site 198094000429 G2 box; other site 198094000430 G3 box; other site 198094000431 Switch II region; other site 198094000432 G4 box; other site 198094000433 G5 box; other site 198094000434 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 198094000435 Elongation Factor G, domain II; Region: EFG_II; pfam14492 198094000436 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 198094000437 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 198094000438 elongation factor Tu; Reviewed; Region: PRK00049 198094000439 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 198094000440 G1 box; other site 198094000441 GEF interaction site [polypeptide binding]; other site 198094000442 GTP/Mg2+ binding site [chemical binding]; other site 198094000443 Switch I region; other site 198094000444 G2 box; other site 198094000445 G3 box; other site 198094000446 Switch II region; other site 198094000447 G4 box; other site 198094000448 G5 box; other site 198094000449 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 198094000450 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 198094000451 Antibiotic Binding Site [chemical binding]; other site 198094000452 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 198094000453 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 198094000454 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 198094000455 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 198094000456 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 198094000457 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 198094000458 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 198094000459 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 198094000460 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 198094000461 putative translocon binding site; other site 198094000462 protein-rRNA interface [nucleotide binding]; other site 198094000463 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 198094000464 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 198094000465 G-X-X-G motif; other site 198094000466 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 198094000467 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 198094000468 23S rRNA interface [nucleotide binding]; other site 198094000469 5S rRNA interface [nucleotide binding]; other site 198094000470 putative antibiotic binding site [chemical binding]; other site 198094000471 L25 interface [polypeptide binding]; other site 198094000472 L27 interface [polypeptide binding]; other site 198094000473 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 198094000474 23S rRNA interface [nucleotide binding]; other site 198094000475 putative translocon interaction site; other site 198094000476 signal recognition particle (SRP54) interaction site; other site 198094000477 L23 interface [polypeptide binding]; other site 198094000478 trigger factor interaction site; other site 198094000479 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 198094000480 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 198094000481 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 198094000482 RNA binding site [nucleotide binding]; other site 198094000483 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 198094000484 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 198094000485 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 198094000486 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 198094000487 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 198094000488 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 198094000489 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 198094000490 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 198094000491 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 198094000492 5S rRNA interface [nucleotide binding]; other site 198094000493 L27 interface [polypeptide binding]; other site 198094000494 23S rRNA interface [nucleotide binding]; other site 198094000495 L5 interface [polypeptide binding]; other site 198094000496 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 198094000497 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 198094000498 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 198094000499 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 198094000500 23S rRNA binding site [nucleotide binding]; other site 198094000501 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 198094000502 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 198094000503 SecY translocase; Region: SecY; pfam00344 198094000504 adenylate kinase; Reviewed; Region: adk; PRK00279 198094000505 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 198094000506 AMP-binding site [chemical binding]; other site 198094000507 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 198094000508 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 198094000509 active site 198094000510 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 198094000511 rRNA binding site [nucleotide binding]; other site 198094000512 predicted 30S ribosome binding site; other site 198094000513 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 198094000514 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 198094000515 30S ribosomal protein S11; Validated; Region: PRK05309 198094000516 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 198094000517 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 198094000518 alphaNTD - beta interaction site [polypeptide binding]; other site 198094000519 alphaNTD homodimer interface [polypeptide binding]; other site 198094000520 alphaNTD - beta' interaction site [polypeptide binding]; other site 198094000521 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 198094000522 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 198094000523 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 198094000524 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198094000525 Walker A/P-loop; other site 198094000526 ATP binding site [chemical binding]; other site 198094000527 Q-loop/lid; other site 198094000528 ABC transporter signature motif; other site 198094000529 Walker B; other site 198094000530 D-loop; other site 198094000531 H-loop/switch region; other site 198094000532 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 198094000533 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198094000534 Walker A/P-loop; other site 198094000535 ATP binding site [chemical binding]; other site 198094000536 Q-loop/lid; other site 198094000537 ABC transporter signature motif; other site 198094000538 Walker B; other site 198094000539 D-loop; other site 198094000540 H-loop/switch region; other site 198094000541 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 198094000542 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 198094000543 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 198094000544 dimerization interface 3.5A [polypeptide binding]; other site 198094000545 active site 198094000546 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 198094000547 23S rRNA interface [nucleotide binding]; other site 198094000548 L3 interface [polypeptide binding]; other site 198094000549 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 198094000550 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 198094000551 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 198094000552 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198094000553 active site 198094000554 metal binding site [ion binding]; metal-binding site 198094000555 Domain of unknown function DUF59; Region: DUF59; cl00941 198094000556 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 198094000557 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 198094000558 Walker A motif; other site 198094000559 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 198094000560 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 198094000561 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 198094000562 NodB motif; other site 198094000563 putative active site [active] 198094000564 putative catalytic site [active] 198094000565 Arginase family; Region: Arginase; cd09989 198094000566 active site 198094000567 Mn binding site [ion binding]; other site 198094000568 oligomer interface [polypeptide binding]; other site 198094000569 Uncharacterized conserved protein [Function unknown]; Region: COG1624 198094000570 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 198094000571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 198094000572 YbbR-like protein; Region: YbbR; pfam07949 198094000573 YbbR-like protein; Region: YbbR; pfam07949 198094000574 YbbR-like protein; Region: YbbR; pfam07949 198094000575 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 198094000576 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 198094000577 active site 198094000578 substrate binding site [chemical binding]; other site 198094000579 metal binding site [ion binding]; metal-binding site 198094000580 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 198094000581 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 198094000582 glutaminase active site [active] 198094000583 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 198094000584 dimer interface [polypeptide binding]; other site 198094000585 active site 198094000586 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 198094000587 dimer interface [polypeptide binding]; other site 198094000588 active site 198094000589 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094000590 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094000591 Transcriptional regulators [Transcription]; Region: GntR; COG1802 198094000592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094000593 DNA-binding site [nucleotide binding]; DNA binding site 198094000594 FCD domain; Region: FCD; pfam07729 198094000595 gluconate transporter; Region: gntP; TIGR00791 198094000596 GntP family permease; Region: GntP_permease; pfam02447 198094000597 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 198094000598 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 198094000599 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 198094000600 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 198094000601 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198094000602 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198094000603 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 198094000604 Predicted membrane protein [Function unknown]; Region: COG2259 198094000605 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 198094000606 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 198094000607 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 198094000608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094000609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094000610 DNA binding residues [nucleotide binding] 198094000611 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 198094000612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094000613 dimer interface [polypeptide binding]; other site 198094000614 conserved gate region; other site 198094000615 putative PBP binding loops; other site 198094000616 ABC-ATPase subunit interface; other site 198094000617 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 198094000618 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 198094000619 Walker A/P-loop; other site 198094000620 ATP binding site [chemical binding]; other site 198094000621 Q-loop/lid; other site 198094000622 ABC transporter signature motif; other site 198094000623 Walker B; other site 198094000624 D-loop; other site 198094000625 H-loop/switch region; other site 198094000626 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094000627 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 198094000628 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 198094000629 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198094000630 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 198094000631 putative NAD(P) binding site [chemical binding]; other site 198094000632 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 198094000633 FAD binding domain; Region: FAD_binding_4; pfam01565 198094000634 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 198094000635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094000636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094000637 putative substrate translocation pore; other site 198094000638 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 198094000639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094000640 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 198094000641 putative substrate translocation pore; other site 198094000642 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 198094000643 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 198094000644 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198094000645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094000646 dimer interface [polypeptide binding]; other site 198094000647 conserved gate region; other site 198094000648 putative PBP binding loops; other site 198094000649 ABC-ATPase subunit interface; other site 198094000650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094000651 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198094000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094000653 dimer interface [polypeptide binding]; other site 198094000654 conserved gate region; other site 198094000655 putative PBP binding loops; other site 198094000656 ABC-ATPase subunit interface; other site 198094000657 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198094000658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094000659 Walker A/P-loop; other site 198094000660 ATP binding site [chemical binding]; other site 198094000661 Q-loop/lid; other site 198094000662 ABC transporter signature motif; other site 198094000663 Walker B; other site 198094000664 D-loop; other site 198094000665 H-loop/switch region; other site 198094000666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094000667 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198094000668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094000669 Walker A/P-loop; other site 198094000670 ATP binding site [chemical binding]; other site 198094000671 Q-loop/lid; other site 198094000672 ABC transporter signature motif; other site 198094000673 Walker B; other site 198094000674 D-loop; other site 198094000675 H-loop/switch region; other site 198094000676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094000677 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094000678 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094000679 peptide binding site [polypeptide binding]; other site 198094000680 YusW-like protein; Region: YusW; pfam14039 198094000681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094000682 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198094000683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094000684 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 198094000685 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094000686 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094000687 peptide binding site [polypeptide binding]; other site 198094000688 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094000689 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094000690 peptide binding site [polypeptide binding]; other site 198094000691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094000692 active site 198094000693 catalytic tetrad [active] 198094000694 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 198094000695 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 198094000696 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 198094000697 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 198094000698 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 198094000699 Sugar transport protein; Region: Sugar_transport; pfam06800 198094000700 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198094000701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094000702 dimer interface [polypeptide binding]; other site 198094000703 conserved gate region; other site 198094000704 putative PBP binding loops; other site 198094000705 ABC-ATPase subunit interface; other site 198094000706 DNA binding domain, excisionase family; Region: excise; TIGR01764 198094000707 PBP superfamily domain; Region: PBP_like; pfam12727 198094000708 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 198094000709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094000710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094000711 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 198094000712 putative dimerization interface [polypeptide binding]; other site 198094000713 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094000714 EamA-like transporter family; Region: EamA; pfam00892 198094000715 YrzO-like protein; Region: YrzO; pfam14142 198094000716 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 198094000717 putative acyl-acceptor binding pocket; other site 198094000718 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094000719 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094000720 DNA binding site [nucleotide binding] 198094000721 domain linker motif; other site 198094000722 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 198094000723 putative ligand binding site [chemical binding]; other site 198094000724 putative dimerization interface [polypeptide binding]; other site 198094000725 Bacterial PH domain; Region: bPH_3; pfam14470 198094000726 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094000727 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094000728 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094000729 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094000730 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 198094000731 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198094000732 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 198094000733 active site 198094000734 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 198094000735 NodB motif; other site 198094000736 putative active site [active] 198094000737 putative catalytic site [active] 198094000738 putative Zn binding site [ion binding]; other site 198094000739 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 198094000740 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 198094000741 lysozyme catalytic site [active] 198094000742 catalytic residue [active] 198094000743 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 198094000744 nucleotide binding site/active site [active] 198094000745 HIT family signature motif; other site 198094000746 catalytic residue [active] 198094000747 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 198094000748 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094000749 ABC transporter; Region: ABC_tran_2; pfam12848 198094000750 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094000751 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198094000752 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 198094000753 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198094000754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094000755 dimer interface [polypeptide binding]; other site 198094000756 conserved gate region; other site 198094000757 putative PBP binding loops; other site 198094000758 ABC-ATPase subunit interface; other site 198094000759 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094000760 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198094000761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094000762 dimer interface [polypeptide binding]; other site 198094000763 conserved gate region; other site 198094000764 putative PBP binding loops; other site 198094000765 ABC-ATPase subunit interface; other site 198094000766 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198094000767 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094000768 Walker A/P-loop; other site 198094000769 ATP binding site [chemical binding]; other site 198094000770 Q-loop/lid; other site 198094000771 ABC transporter signature motif; other site 198094000772 Walker B; other site 198094000773 D-loop; other site 198094000774 H-loop/switch region; other site 198094000775 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094000776 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 198094000777 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094000778 Walker A/P-loop; other site 198094000779 ATP binding site [chemical binding]; other site 198094000780 Q-loop/lid; other site 198094000781 ABC transporter signature motif; other site 198094000782 Walker B; other site 198094000783 D-loop; other site 198094000784 H-loop/switch region; other site 198094000785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094000786 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 198094000787 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 198094000788 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 198094000789 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 198094000790 dimer interface [polypeptide binding]; other site 198094000791 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 198094000792 active site 198094000793 Fe binding site [ion binding]; other site 198094000794 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 198094000795 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 198094000796 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 198094000797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094000798 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094000799 putative substrate translocation pore; other site 198094000800 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 198094000801 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198094000802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198094000803 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198094000804 helicase 45; Provisional; Region: PTZ00424 198094000805 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198094000806 ATP binding site [chemical binding]; other site 198094000807 Mg++ binding site [ion binding]; other site 198094000808 motif III; other site 198094000809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094000810 nucleotide binding region [chemical binding]; other site 198094000811 ATP-binding site [chemical binding]; other site 198094000812 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 198094000813 Rhomboid family; Region: Rhomboid; pfam01694 198094000814 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 198094000815 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 198094000816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 198094000817 alanine racemase; Reviewed; Region: alr; PRK00053 198094000818 active site 198094000819 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198094000820 dimer interface [polypeptide binding]; other site 198094000821 substrate binding site [chemical binding]; other site 198094000822 catalytic residues [active] 198094000823 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 198094000824 PemK-like protein; Region: PemK; pfam02452 198094000825 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 198094000826 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 198094000827 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 198094000828 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 198094000829 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 198094000830 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 198094000831 RNA binding site [nucleotide binding]; other site 198094000832 hypothetical protein; Provisional; Region: PRK04351 198094000833 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 198094000834 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 198094000835 Glycoprotease family; Region: Peptidase_M22; pfam00814 198094000836 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 198094000837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094000838 Coenzyme A binding pocket [chemical binding]; other site 198094000839 UGMP family protein; Validated; Region: PRK09604 198094000840 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 198094000841 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 198094000842 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 198094000843 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094000844 ABC transporter; Region: ABC_tran_2; pfam12848 198094000845 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094000846 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 198094000847 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 198094000848 CoA binding domain; Region: CoA_binding; pfam02629 198094000849 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 198094000850 CAAX protease self-immunity; Region: Abi; pfam02517 198094000851 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 198094000852 oligomerisation interface [polypeptide binding]; other site 198094000853 mobile loop; other site 198094000854 roof hairpin; other site 198094000855 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 198094000856 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 198094000857 ring oligomerisation interface [polypeptide binding]; other site 198094000858 ATP/Mg binding site [chemical binding]; other site 198094000859 stacking interactions; other site 198094000860 hinge regions; other site 198094000861 GMP synthase; Reviewed; Region: guaA; PRK00074 198094000862 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 198094000863 AMP/PPi binding site [chemical binding]; other site 198094000864 candidate oxyanion hole; other site 198094000865 catalytic triad [active] 198094000866 potential glutamine specificity residues [chemical binding]; other site 198094000867 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 198094000868 ATP Binding subdomain [chemical binding]; other site 198094000869 Ligand Binding sites [chemical binding]; other site 198094000870 Dimerization subdomain; other site 198094000871 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198094000872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094000873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094000874 active site 198094000875 phosphorylation site [posttranslational modification] 198094000876 intermolecular recognition site; other site 198094000877 dimerization interface [polypeptide binding]; other site 198094000878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094000879 DNA binding site [nucleotide binding] 198094000880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094000881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094000882 dimerization interface [polypeptide binding]; other site 198094000883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094000884 dimer interface [polypeptide binding]; other site 198094000885 phosphorylation site [posttranslational modification] 198094000886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094000887 ATP binding site [chemical binding]; other site 198094000888 Mg2+ binding site [ion binding]; other site 198094000889 G-X-G motif; other site 198094000890 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 198094000891 putative ligand binding site [chemical binding]; other site 198094000892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094000893 S-adenosylmethionine binding site [chemical binding]; other site 198094000894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094000895 S-adenosylmethionine binding site [chemical binding]; other site 198094000896 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 198094000897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094000898 S-adenosylmethionine binding site [chemical binding]; other site 198094000899 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094000900 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 198094000901 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 198094000902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094000903 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 198094000904 Walker A/P-loop; other site 198094000905 ATP binding site [chemical binding]; other site 198094000906 Q-loop/lid; other site 198094000907 ABC transporter signature motif; other site 198094000908 Walker B; other site 198094000909 D-loop; other site 198094000910 H-loop/switch region; other site 198094000911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094000912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094000913 dimer interface [polypeptide binding]; other site 198094000914 phosphorylation site [posttranslational modification] 198094000915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094000916 ATP binding site [chemical binding]; other site 198094000917 Mg2+ binding site [ion binding]; other site 198094000918 G-X-G motif; other site 198094000919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094000920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094000921 active site 198094000922 phosphorylation site [posttranslational modification] 198094000923 intermolecular recognition site; other site 198094000924 dimerization interface [polypeptide binding]; other site 198094000925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094000926 DNA binding site [nucleotide binding] 198094000927 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 198094000928 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 198094000929 ATP-grasp domain; Region: ATP-grasp; pfam02222 198094000930 adenylosuccinate lyase; Provisional; Region: PRK07492 198094000931 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 198094000932 tetramer interface [polypeptide binding]; other site 198094000933 active site 198094000934 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 198094000935 ATP binding site [chemical binding]; other site 198094000936 active site 198094000937 substrate binding site [chemical binding]; other site 198094000938 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 198094000939 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 198094000940 putative active site [active] 198094000941 catalytic triad [active] 198094000942 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 198094000943 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 198094000944 dimerization interface [polypeptide binding]; other site 198094000945 ATP binding site [chemical binding]; other site 198094000946 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 198094000947 dimerization interface [polypeptide binding]; other site 198094000948 ATP binding site [chemical binding]; other site 198094000949 amidophosphoribosyltransferase; Provisional; Region: PRK06781 198094000950 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 198094000951 active site 198094000952 tetramer interface [polypeptide binding]; other site 198094000953 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094000954 active site 198094000955 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 198094000956 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 198094000957 dimerization interface [polypeptide binding]; other site 198094000958 putative ATP binding site [chemical binding]; other site 198094000959 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 198094000960 active site 198094000961 substrate binding site [chemical binding]; other site 198094000962 cosubstrate binding site; other site 198094000963 catalytic site [active] 198094000964 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 198094000965 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 198094000966 purine monophosphate binding site [chemical binding]; other site 198094000967 dimer interface [polypeptide binding]; other site 198094000968 putative catalytic residues [active] 198094000969 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 198094000970 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 198094000971 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 198094000972 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 198094000973 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 198094000974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 198094000975 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 198094000976 prohibitin homologues; Region: PHB; smart00244 198094000977 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 198094000978 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 198094000979 substrate binding site [chemical binding]; other site 198094000980 putative active site [active] 198094000981 dimer interface [polypeptide binding]; other site 198094000982 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 198094000983 Part of AAA domain; Region: AAA_19; pfam13245 198094000984 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198094000985 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 198094000986 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 198094000987 nucleotide binding pocket [chemical binding]; other site 198094000988 K-X-D-G motif; other site 198094000989 catalytic site [active] 198094000990 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 198094000991 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 198094000992 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 198094000993 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 198094000994 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 198094000995 Dimer interface [polypeptide binding]; other site 198094000996 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 198094000997 putative dimer interface [polypeptide binding]; other site 198094000998 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 198094000999 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 198094001000 putative dimer interface [polypeptide binding]; other site 198094001001 hypothetical protein; Provisional; Region: PRK10621 198094001002 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 198094001003 Glutamate binding site [chemical binding]; other site 198094001004 homodimer interface [polypeptide binding]; other site 198094001005 NAD binding site [chemical binding]; other site 198094001006 catalytic residues [active] 198094001007 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 198094001008 catalytic triad [active] 198094001009 conserved cis-peptide bond; other site 198094001010 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 198094001011 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 198094001012 Walker A/P-loop; other site 198094001013 ATP binding site [chemical binding]; other site 198094001014 Q-loop/lid; other site 198094001015 ABC transporter signature motif; other site 198094001016 Walker B; other site 198094001017 D-loop; other site 198094001018 H-loop/switch region; other site 198094001019 NIL domain; Region: NIL; pfam09383 198094001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094001021 dimer interface [polypeptide binding]; other site 198094001022 conserved gate region; other site 198094001023 putative PBP binding loops; other site 198094001024 ABC-ATPase subunit interface; other site 198094001025 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 198094001026 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 198094001027 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 198094001028 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094001029 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094001030 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 198094001031 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 198094001032 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 198094001033 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 198094001034 GatB domain; Region: GatB_Yqey; pfam02637 198094001035 putative lipid kinase; Reviewed; Region: PRK13337 198094001036 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 198094001037 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 198094001038 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 198094001039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094001040 motif II; other site 198094001041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094001042 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198094001043 inhibitor-cofactor binding pocket; inhibition site 198094001044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094001045 catalytic residue [active] 198094001046 PAS domain; Region: PAS_9; pfam13426 198094001047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094001048 putative active site [active] 198094001049 heme pocket [chemical binding]; other site 198094001050 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 198094001051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094001052 Walker A motif; other site 198094001053 ATP binding site [chemical binding]; other site 198094001054 Walker B motif; other site 198094001055 arginine finger; other site 198094001056 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 198094001057 tetramerization interface [polypeptide binding]; other site 198094001058 NAD(P) binding site [chemical binding]; other site 198094001059 catalytic residues [active] 198094001060 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 198094001061 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 198094001062 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 198094001063 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 198094001064 putative active site [active] 198094001065 putative metal binding site [ion binding]; other site 198094001066 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 198094001067 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 198094001068 putative active site [active] 198094001069 putative metal binding site [ion binding]; other site 198094001070 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198094001071 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198094001072 Nucleoside recognition; Region: Gate; pfam07670 198094001073 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198094001074 TRAM domain; Region: TRAM; cl01282 198094001075 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 198094001076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094001077 S-adenosylmethionine binding site [chemical binding]; other site 198094001078 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198094001079 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 198094001080 FMN binding site [chemical binding]; other site 198094001081 active site 198094001082 catalytic residues [active] 198094001083 substrate binding site [chemical binding]; other site 198094001084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 198094001085 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 198094001086 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 198094001087 Protein of unknown function DUF45; Region: DUF45; pfam01863 198094001088 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 198094001089 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 198094001090 active site 198094001091 Predicted transcriptional regulator [Transcription]; Region: COG3355 198094001092 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 198094001093 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 198094001094 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 198094001095 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 198094001096 amidohydrolase; Region: amidohydrolases; TIGR01891 198094001097 metal binding site [ion binding]; metal-binding site 198094001098 putative dimer interface [polypeptide binding]; other site 198094001099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094001100 S-adenosylmethionine binding site [chemical binding]; other site 198094001101 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 198094001102 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 198094001103 catalytic residue [active] 198094001104 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 198094001105 catalytic residues [active] 198094001106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094001107 peroxiredoxin; Region: AhpC; TIGR03137 198094001108 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 198094001109 dimer interface [polypeptide binding]; other site 198094001110 decamer (pentamer of dimers) interface [polypeptide binding]; other site 198094001111 catalytic triad [active] 198094001112 peroxidatic and resolving cysteines [active] 198094001113 5-methylribose kinase; Reviewed; Region: PRK12396 198094001114 Phosphotransferase enzyme family; Region: APH; pfam01636 198094001115 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 198094001116 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 198094001117 intersubunit interface [polypeptide binding]; other site 198094001118 active site 198094001119 Zn2+ binding site [ion binding]; other site 198094001120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094001121 ABC-ATPase subunit interface; other site 198094001122 dimer interface [polypeptide binding]; other site 198094001123 putative PBP binding regions; other site 198094001124 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094001125 ABC-ATPase subunit interface; other site 198094001126 dimer interface [polypeptide binding]; other site 198094001127 putative PBP binding regions; other site 198094001128 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198094001129 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 198094001130 putative ligand binding residues [chemical binding]; other site 198094001131 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 198094001132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094001133 DNA binding domain, excisionase family; Region: excise; TIGR01764 198094001134 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 198094001135 Sm and related proteins; Region: Sm_like; cl00259 198094001136 Sm1 motif; other site 198094001137 RNA binding site [nucleotide binding]; other site 198094001138 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 198094001139 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 198094001140 hypothetical protein; Provisional; Region: PRK06851 198094001141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094001142 Walker A motif; other site 198094001143 ATP binding site [chemical binding]; other site 198094001144 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 198094001145 G1 box; other site 198094001146 GTP/Mg2+ binding site [chemical binding]; other site 198094001147 G2 box; other site 198094001148 Switch I region; other site 198094001149 G3 box; other site 198094001150 Switch II region; other site 198094001151 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 198094001152 benzoate transport; Region: 2A0115; TIGR00895 198094001153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094001154 putative substrate translocation pore; other site 198094001155 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 198094001156 FAD dependent oxidoreductase; Region: DAO; pfam01266 198094001157 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 198094001158 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 198094001159 [2Fe-2S] cluster binding site [ion binding]; other site 198094001160 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 198094001161 putative di-iron ligands [ion binding]; other site 198094001162 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 198094001163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094001164 dimer interface [polypeptide binding]; other site 198094001165 conserved gate region; other site 198094001166 putative PBP binding loops; other site 198094001167 ABC-ATPase subunit interface; other site 198094001168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198094001169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198094001170 substrate binding pocket [chemical binding]; other site 198094001171 membrane-bound complex binding site; other site 198094001172 hinge residues; other site 198094001173 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198094001174 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198094001175 Walker A/P-loop; other site 198094001176 ATP binding site [chemical binding]; other site 198094001177 Q-loop/lid; other site 198094001178 ABC transporter signature motif; other site 198094001179 Walker B; other site 198094001180 D-loop; other site 198094001181 H-loop/switch region; other site 198094001182 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198094001183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094001184 dimerization interface [polypeptide binding]; other site 198094001185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 198094001186 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094001187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198094001188 dimer interface [polypeptide binding]; other site 198094001189 putative CheW interface [polypeptide binding]; other site 198094001190 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198094001191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094001192 dimerization interface [polypeptide binding]; other site 198094001193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 198094001194 dimer interface [polypeptide binding]; other site 198094001195 putative CheW interface [polypeptide binding]; other site 198094001196 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 198094001197 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 198094001198 Ca binding site [ion binding]; other site 198094001199 active site 198094001200 catalytic site [active] 198094001201 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198094001202 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 198094001203 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198094001204 active site turn [active] 198094001205 phosphorylation site [posttranslational modification] 198094001206 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 198094001207 putative catalytic site [active] 198094001208 putative metal binding site [ion binding]; other site 198094001209 putative phosphate binding site [ion binding]; other site 198094001210 Predicted membrane protein [Function unknown]; Region: COG1511 198094001211 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 198094001212 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094001213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094001214 DNA topoisomerase III; Provisional; Region: PRK07726 198094001215 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 198094001216 active site 198094001217 putative interdomain interaction site [polypeptide binding]; other site 198094001218 putative metal-binding site [ion binding]; other site 198094001219 putative nucleotide binding site [chemical binding]; other site 198094001220 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198094001221 domain I; other site 198094001222 DNA binding groove [nucleotide binding] 198094001223 phosphate binding site [ion binding]; other site 198094001224 domain II; other site 198094001225 domain III; other site 198094001226 nucleotide binding site [chemical binding]; other site 198094001227 catalytic site [active] 198094001228 domain IV; other site 198094001229 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 198094001230 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 198094001231 substrate binding site [chemical binding]; other site 198094001232 multimerization interface [polypeptide binding]; other site 198094001233 ATP binding site [chemical binding]; other site 198094001234 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 198094001235 thiamine phosphate binding site [chemical binding]; other site 198094001236 active site 198094001237 pyrophosphate binding site [ion binding]; other site 198094001238 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 198094001239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094001240 dimerization interface [polypeptide binding]; other site 198094001241 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094001242 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198094001243 dimer interface [polypeptide binding]; other site 198094001244 putative CheW interface [polypeptide binding]; other site 198094001245 Domain of unknown function DUF77; Region: DUF77; pfam01910 198094001246 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198094001247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094001248 dimer interface [polypeptide binding]; other site 198094001249 conserved gate region; other site 198094001250 putative PBP binding loops; other site 198094001251 ABC-ATPase subunit interface; other site 198094001252 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 198094001253 NMT1/THI5 like; Region: NMT1; pfam09084 198094001254 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198094001255 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198094001256 Walker A/P-loop; other site 198094001257 ATP binding site [chemical binding]; other site 198094001258 Q-loop/lid; other site 198094001259 ABC transporter signature motif; other site 198094001260 Walker B; other site 198094001261 D-loop; other site 198094001262 H-loop/switch region; other site 198094001263 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 198094001264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094001265 Walker A/P-loop; other site 198094001266 ATP binding site [chemical binding]; other site 198094001267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094001268 ATP binding site [chemical binding]; other site 198094001269 Q-loop/lid; other site 198094001270 Q-loop/lid; other site 198094001271 ABC transporter signature motif; other site 198094001272 ABC transporter signature motif; other site 198094001273 Walker B; other site 198094001274 Walker B; other site 198094001275 D-loop; other site 198094001276 D-loop; other site 198094001277 H-loop/switch region; other site 198094001278 ABC transporter; Region: ABC_tran_2; pfam12848 198094001279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094001280 Glyco_18 domain; Region: Glyco_18; smart00636 198094001281 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 198094001282 active site 198094001283 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198094001284 Interdomain contacts; other site 198094001285 Cytokine receptor motif; other site 198094001286 Cellulose binding domain; Region: CBM_2; pfam00553 198094001287 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 198094001288 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198094001289 catalytic residues [active] 198094001290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094001291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094001292 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 198094001293 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094001294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094001295 putative substrate translocation pore; other site 198094001296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094001297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094001298 non-specific DNA binding site [nucleotide binding]; other site 198094001299 salt bridge; other site 198094001300 sequence-specific DNA binding site [nucleotide binding]; other site 198094001301 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 198094001302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094001303 putative substrate translocation pore; other site 198094001304 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 198094001305 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 198094001306 YesK-like protein; Region: YesK; pfam14150 198094001307 prolyl-tRNA synthetase; Provisional; Region: PRK08661 198094001308 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 198094001309 dimer interface [polypeptide binding]; other site 198094001310 motif 1; other site 198094001311 active site 198094001312 motif 2; other site 198094001313 motif 3; other site 198094001314 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 198094001315 anticodon binding site; other site 198094001316 zinc-binding site [ion binding]; other site 198094001317 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198094001318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198094001319 nucleotide binding site [chemical binding]; other site 198094001320 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 198094001321 putative metal binding site [ion binding]; other site 198094001322 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 198094001323 putative metal binding site [ion binding]; other site 198094001324 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 198094001325 putative metal binding site [ion binding]; other site 198094001326 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 198094001327 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 198094001328 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 198094001329 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 198094001330 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 198094001331 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 198094001332 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198094001333 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 198094001334 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 198094001335 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 198094001336 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 198094001337 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198094001338 active site 198094001339 YtxH-like protein; Region: YtxH; pfam12732 198094001340 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 198094001341 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 198094001342 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 198094001343 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198094001344 Soluble P-type ATPase [General function prediction only]; Region: COG4087 198094001345 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094001346 EamA-like transporter family; Region: EamA; pfam00892 198094001347 EamA-like transporter family; Region: EamA; pfam00892 198094001348 YhhN-like protein; Region: YhhN; pfam07947 198094001349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094001350 binding surface 198094001351 Tetratricopeptide repeat; Region: TPR_16; pfam13432 198094001352 TPR motif; other site 198094001353 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198094001354 Predicted membrane protein [Function unknown]; Region: COG2510 198094001355 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 198094001356 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 198094001357 calcium/proton exchanger (cax); Region: cax; TIGR00378 198094001358 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198094001359 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198094001360 YfkD-like protein; Region: YfkD; pfam14167 198094001361 Radical SAM superfamily; Region: Radical_SAM; pfam04055 198094001362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094001363 FeS/SAM binding site; other site 198094001364 YfkB-like domain; Region: YfkB; pfam08756 198094001365 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 198094001366 Fumarase C-terminus; Region: Fumerase_C; pfam05683 198094001367 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 198094001368 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 198094001369 NodB motif; other site 198094001370 active site 198094001371 catalytic site [active] 198094001372 Cd binding site [ion binding]; other site 198094001373 TRAM domain; Region: TRAM; pfam01938 198094001374 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 198094001375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094001376 S-adenosylmethionine binding site [chemical binding]; other site 198094001377 prophage; lysogenic prophage region. Best Hits not completed. attL/R; PHAGE01 198094001378 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 198094001379 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 198094001380 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 198094001381 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 198094001382 Int/Topo IB signature motif; other site 198094001383 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094001384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094001385 non-specific DNA binding site [nucleotide binding]; other site 198094001386 salt bridge; other site 198094001387 sequence-specific DNA binding site [nucleotide binding]; other site 198094001388 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094001389 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094001390 non-specific DNA binding site [nucleotide binding]; other site 198094001391 salt bridge; other site 198094001392 sequence-specific DNA binding site [nucleotide binding]; other site 198094001393 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094001394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094001395 non-specific DNA binding site [nucleotide binding]; other site 198094001396 salt bridge; other site 198094001397 sequence-specific DNA binding site [nucleotide binding]; other site 198094001398 phage regulatory protein, rha family; Region: phage_pRha; TIGR02681 198094001399 ORF6C domain; Region: ORF6C; pfam10552 198094001400 Helix-turn-helix domain; Region: HTH_17; cl17695 198094001401 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 198094001402 hypothetical protein; Validated; Region: PRK08116 198094001403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094001404 Walker A motif; other site 198094001405 ATP binding site [chemical binding]; other site 198094001406 Walker B motif; other site 198094001407 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 198094001408 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 198094001409 putative metal binding site [ion binding]; other site 198094001410 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 198094001411 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 198094001412 HNH endonuclease; Region: HNH; pfam01844 198094001413 Helix-turn-helix domain; Region: HTH_17; pfam12728 198094001414 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 198094001415 Phage Terminase; Region: Terminase_1; cl19862 198094001416 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 198094001417 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 198094001418 Phage capsid family; Region: Phage_capsid; pfam05065 198094001419 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 198094001420 oligomerization interface [polypeptide binding]; other site 198094001421 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 198094001422 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 198094001423 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 198094001424 Phage-related minor tail protein [Function unknown]; Region: COG5280 198094001425 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 198094001426 Domain of unknown function (DUF4515); Region: DUF4515; pfam14988 198094001427 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094001428 Phage tail protein; Region: Sipho_tail; pfam05709 198094001429 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 198094001430 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 198094001431 Haemolysin XhlA; Region: XhlA; pfam10779 198094001432 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 198094001433 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 198094001434 active site 198094001435 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 198094001436 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 198094001437 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 198094001438 dimerization interface 3.5A [polypeptide binding]; other site 198094001439 active site 198094001440 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 198094001441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094001442 Walker A motif; other site 198094001443 ATP binding site [chemical binding]; other site 198094001444 Walker B motif; other site 198094001445 arginine finger; other site 198094001446 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198094001447 hypothetical protein; Validated; Region: PRK06748 198094001448 S-methylmethionine transporter; Provisional; Region: PRK11387 198094001449 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094001450 acetylornithine deacetylase; Validated; Region: PRK08596 198094001451 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 198094001452 metal binding site [ion binding]; metal-binding site 198094001453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094001454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094001455 sequence-specific DNA binding site [nucleotide binding]; other site 198094001456 salt bridge; other site 198094001457 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 198094001458 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 198094001459 Domain of unknown function DUF; Region: DUF204; pfam02659 198094001460 Domain of unknown function DUF; Region: DUF204; pfam02659 198094001461 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 198094001462 glutaminase A; Region: Gln_ase; TIGR03814 198094001463 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 198094001464 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198094001465 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198094001466 active site turn [active] 198094001467 phosphorylation site [posttranslational modification] 198094001468 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094001469 Sm and related proteins; Region: Sm_like; cl00259 198094001470 heptamer interface [polypeptide binding]; other site 198094001471 Sm1 motif; other site 198094001472 hexamer interface [polypeptide binding]; other site 198094001473 RNA binding site [nucleotide binding]; other site 198094001474 Sm2 motif; other site 198094001475 Sm and related proteins; Region: Sm_like; cl00259 198094001476 heptamer interface [polypeptide binding]; other site 198094001477 Sm1 motif; other site 198094001478 hexamer interface [polypeptide binding]; other site 198094001479 RNA binding site [nucleotide binding]; other site 198094001480 Sm2 motif; other site 198094001481 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198094001482 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 198094001483 active site 198094001484 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198094001485 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094001486 active site 198094001487 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198094001488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094001489 NAD(P) binding site [chemical binding]; other site 198094001490 active site 198094001491 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094001492 active site 198094001493 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198094001494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094001495 active site 198094001496 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 198094001497 Pyruvate formate lyase 1; Region: PFL1; cd01678 198094001498 coenzyme A binding site [chemical binding]; other site 198094001499 active site 198094001500 catalytic residues [active] 198094001501 glycine loop; other site 198094001502 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 198094001503 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094001504 FeS/SAM binding site; other site 198094001505 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 198094001506 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 198094001507 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 198094001508 YfhE-like protein; Region: YfhE; pfam14152 198094001509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094001510 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 198094001511 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 198094001512 active site 198094001513 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 198094001514 TIGR01777 family protein; Region: yfcH 198094001515 putative NAD(P) binding site [chemical binding]; other site 198094001516 putative active site [active] 198094001517 recombination regulator RecX; Provisional; Region: recX; PRK14135 198094001518 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 198094001519 YpzG-like protein; Region: YpzG; pfam14139 198094001520 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 198094001521 WVELL protein; Region: WVELL; pfam14043 198094001522 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 198094001523 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 198094001524 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198094001525 minor groove reading motif; other site 198094001526 helix-hairpin-helix signature motif; other site 198094001527 substrate binding pocket [chemical binding]; other site 198094001528 active site 198094001529 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 198094001530 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 198094001531 DNA binding and oxoG recognition site [nucleotide binding] 198094001532 small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; TIGR01442 198094001533 YgaB-like protein; Region: YgaB; pfam14182 198094001534 hypothetical protein; Provisional; Region: PRK13662 198094001535 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 198094001536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094001537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094001538 Walker A/P-loop; other site 198094001539 ATP binding site [chemical binding]; other site 198094001540 Q-loop/lid; other site 198094001541 ABC transporter signature motif; other site 198094001542 Walker B; other site 198094001543 D-loop; other site 198094001544 H-loop/switch region; other site 198094001545 Predicted membrane protein [Function unknown]; Region: COG4129 198094001546 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 198094001547 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 198094001548 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 198094001549 active site 198094001550 dimer interface [polypeptide binding]; other site 198094001551 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 198094001552 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 198094001553 active site 198094001554 FMN binding site [chemical binding]; other site 198094001555 substrate binding site [chemical binding]; other site 198094001556 3Fe-4S cluster binding site [ion binding]; other site 198094001557 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 198094001558 domain_subunit interface; other site 198094001559 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 198094001560 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094001561 inhibitor-cofactor binding pocket; inhibition site 198094001562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094001563 catalytic residue [active] 198094001564 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 198094001565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094001566 Walker A/P-loop; other site 198094001567 ATP binding site [chemical binding]; other site 198094001568 Q-loop/lid; other site 198094001569 ABC transporter signature motif; other site 198094001570 Walker B; other site 198094001571 D-loop; other site 198094001572 H-loop/switch region; other site 198094001573 ABC-2 type transporter; Region: ABC2_membrane; cl17235 198094001574 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 198094001575 Ion channel; Region: Ion_trans_2; pfam07885 198094001576 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 198094001577 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 198094001578 catalytic triad [active] 198094001579 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198094001580 metal binding site 2 [ion binding]; metal-binding site 198094001581 putative DNA binding helix; other site 198094001582 metal binding site 1 [ion binding]; metal-binding site 198094001583 dimer interface [polypeptide binding]; other site 198094001584 structural Zn2+ binding site [ion binding]; other site 198094001585 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 198094001586 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 198094001587 hypothetical protein; Provisional; Region: PRK12378 198094001588 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 198094001589 nudix motif; other site 198094001590 Transglycosylase; Region: Transgly; pfam00912 198094001591 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 198094001592 Thioredoxin; Region: Thioredoxin_4; pfam13462 198094001593 epoxyqueuosine reductase; Region: TIGR00276 198094001594 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 198094001595 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 198094001596 HEAT-like repeat; Region: HEAT_EZ; pfam13513 198094001597 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 198094001598 Putative amidase domain; Region: Amidase_6; pfam12671 198094001599 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 198094001600 PAS fold; Region: PAS_4; pfam08448 198094001601 PAS domain S-box; Region: sensory_box; TIGR00229 198094001602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094001603 putative active site [active] 198094001604 heme pocket [chemical binding]; other site 198094001605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198094001606 metal binding site [ion binding]; metal-binding site 198094001607 active site 198094001608 I-site; other site 198094001609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198094001610 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 198094001611 PrkA AAA domain; Region: AAA_PrkA; smart00763 198094001612 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 198094001613 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 198094001614 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094001615 heme-binding site [chemical binding]; other site 198094001616 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198094001617 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 198094001618 Leucine rich repeat; Region: LRR_8; pfam13855 198094001619 Substrate binding site [chemical binding]; other site 198094001620 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198094001621 Leucine rich repeat; Region: LRR_8; pfam13855 198094001622 Leucine rich repeat; Region: LRR_8; pfam13855 198094001623 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198094001624 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198094001625 Leucine rich repeat; Region: LRR_8; pfam13855 198094001626 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198094001627 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198094001628 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198094001629 Leucine rich repeat; Region: LRR_8; pfam13855 198094001630 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198094001631 Neuromodulin; Region: Neuromodulin; pfam06614 198094001632 RCSD region; Region: RCSD; pfam05177 198094001633 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 198094001634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094001635 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198094001636 Coenzyme A binding pocket [chemical binding]; other site 198094001637 BCCT family transporter; Region: BCCT; pfam02028 198094001638 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 198094001639 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 198094001640 FOG: PKD repeat [General function prediction only]; Region: COG3291 198094001641 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 198094001642 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 198094001643 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 198094001644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 198094001645 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 198094001646 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 198094001647 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198094001648 Cache domain; Region: Cache_1; pfam02743 198094001649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094001650 dimerization interface [polypeptide binding]; other site 198094001651 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094001652 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198094001653 dimer interface [polypeptide binding]; other site 198094001654 putative CheW interface [polypeptide binding]; other site 198094001655 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 198094001656 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 198094001657 PAS domain; Region: PAS; smart00091 198094001658 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 198094001659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094001660 ATP binding site [chemical binding]; other site 198094001661 Mg2+ binding site [ion binding]; other site 198094001662 G-X-G motif; other site 198094001663 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 198094001664 Citrate transporter; Region: CitMHS; pfam03600 198094001665 hypothetical protein; Provisional; Region: PRK12784 198094001666 NosL; Region: NosL; cl01769 198094001667 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198094001668 Ankyrin repeat; Region: Ank; pfam00023 198094001669 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198094001670 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198094001671 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198094001672 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 198094001673 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 198094001674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094001675 Walker A/P-loop; other site 198094001676 ATP binding site [chemical binding]; other site 198094001677 Q-loop/lid; other site 198094001678 ABC transporter signature motif; other site 198094001679 Walker B; other site 198094001680 D-loop; other site 198094001681 H-loop/switch region; other site 198094001682 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198094001683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094001684 dimer interface [polypeptide binding]; other site 198094001685 conserved gate region; other site 198094001686 putative PBP binding loops; other site 198094001687 ABC-ATPase subunit interface; other site 198094001688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 198094001689 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198094001690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094001691 dimer interface [polypeptide binding]; other site 198094001692 conserved gate region; other site 198094001693 putative PBP binding loops; other site 198094001694 ABC-ATPase subunit interface; other site 198094001695 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198094001696 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198094001697 putative protein phosphatase; Region: PHA02239 198094001698 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 198094001699 active site 198094001700 metal binding site [ion binding]; metal-binding site 198094001701 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094001702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094001703 active site 198094001704 phosphorylation site [posttranslational modification] 198094001705 intermolecular recognition site; other site 198094001706 dimerization interface [polypeptide binding]; other site 198094001707 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094001708 DNA binding site [nucleotide binding] 198094001709 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094001710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094001711 dimer interface [polypeptide binding]; other site 198094001712 phosphorylation site [posttranslational modification] 198094001713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094001714 ATP binding site [chemical binding]; other site 198094001715 Mg2+ binding site [ion binding]; other site 198094001716 G-X-G motif; other site 198094001717 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 198094001718 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 198094001719 putative active site [active] 198094001720 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198094001721 Cache domain; Region: Cache_1; pfam02743 198094001722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094001723 dimerization interface [polypeptide binding]; other site 198094001724 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 198094001725 dimer interface [polypeptide binding]; other site 198094001726 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094001727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198094001728 dimer interface [polypeptide binding]; other site 198094001729 putative CheW interface [polypeptide binding]; other site 198094001730 sensory histidine kinase DcuS; Provisional; Region: PRK11086 198094001731 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 198094001732 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 198094001733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094001734 ATP binding site [chemical binding]; other site 198094001735 Mg2+ binding site [ion binding]; other site 198094001736 G-X-G motif; other site 198094001737 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 198094001738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094001739 active site 198094001740 phosphorylation site [posttranslational modification] 198094001741 intermolecular recognition site; other site 198094001742 dimerization interface [polypeptide binding]; other site 198094001743 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 198094001744 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 198094001745 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198094001746 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 198094001747 putative NAD(P) binding site [chemical binding]; other site 198094001748 EamA-like transporter family; Region: EamA; pfam00892 198094001749 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 198094001750 EamA-like transporter family; Region: EamA; pfam00892 198094001751 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198094001752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094001753 DNA-binding site [nucleotide binding]; DNA binding site 198094001754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094001755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094001756 homodimer interface [polypeptide binding]; other site 198094001757 catalytic residue [active] 198094001758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094001759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094001760 Coenzyme A binding pocket [chemical binding]; other site 198094001761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094001762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094001763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094001764 dimerization interface [polypeptide binding]; other site 198094001765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094001766 dimer interface [polypeptide binding]; other site 198094001767 phosphorylation site [posttranslational modification] 198094001768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094001769 ATP binding site [chemical binding]; other site 198094001770 Mg2+ binding site [ion binding]; other site 198094001771 G-X-G motif; other site 198094001772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094001773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094001774 active site 198094001775 phosphorylation site [posttranslational modification] 198094001776 intermolecular recognition site; other site 198094001777 dimerization interface [polypeptide binding]; other site 198094001778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094001779 DNA binding site [nucleotide binding] 198094001780 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094001781 Arrestin_N terminal like; Region: LDB19; pfam13002 198094001782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094001783 Coenzyme A binding pocket [chemical binding]; other site 198094001784 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 198094001785 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 198094001786 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198094001787 catalytic loop [active] 198094001788 iron binding site [ion binding]; other site 198094001789 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 198094001790 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198094001791 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 198094001792 [4Fe-4S] binding site [ion binding]; other site 198094001793 molybdopterin cofactor binding site; other site 198094001794 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 198094001795 molybdopterin cofactor binding site; other site 198094001796 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 198094001797 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 198094001798 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 198094001799 putative active site [active] 198094001800 catalytic site [active] 198094001801 putative metal binding site [ion binding]; other site 198094001802 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 198094001803 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 198094001804 hexamer interface [polypeptide binding]; other site 198094001805 ligand binding site [chemical binding]; other site 198094001806 putative active site [active] 198094001807 NAD(P) binding site [chemical binding]; other site 198094001808 amino acid transporter; Region: 2A0306; TIGR00909 198094001809 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094001810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094001811 dimerization interface [polypeptide binding]; other site 198094001812 putative DNA binding site [nucleotide binding]; other site 198094001813 putative Zn2+ binding site [ion binding]; other site 198094001814 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198094001815 metal-binding site [ion binding] 198094001816 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 198094001817 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198094001818 metal-binding site [ion binding] 198094001819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198094001820 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 198094001821 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 198094001822 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 198094001823 active site 198094001824 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094001825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094001826 non-specific DNA binding site [nucleotide binding]; other site 198094001827 salt bridge; other site 198094001828 sequence-specific DNA binding site [nucleotide binding]; other site 198094001829 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198094001830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094001831 TPR motif; other site 198094001832 binding surface 198094001833 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198094001834 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 198094001835 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 198094001836 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 198094001837 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 198094001838 active site 198094001839 Zn binding site [ion binding]; other site 198094001840 Uncharacterized conserved protein [Function unknown]; Region: COG0398 198094001841 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 198094001842 Transcriptional regulator PadR-like family; Region: PadR; cl17335 198094001843 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 198094001844 VanW like protein; Region: VanW; pfam04294 198094001845 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 198094001846 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198094001847 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198094001848 Nucleoside recognition; Region: Gate; pfam07670 198094001849 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198094001850 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 198094001851 putative metal binding site [ion binding]; other site 198094001852 Domain of unknown function DUF21; Region: DUF21; pfam01595 198094001853 FOG: CBS domain [General function prediction only]; Region: COG0517 198094001854 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198094001855 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 198094001856 Aspartase; Region: Aspartase; cd01357 198094001857 active sites [active] 198094001858 tetramer interface [polypeptide binding]; other site 198094001859 L-lactate permease; Region: Lactate_perm; cl00701 198094001860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094001861 dimerization interface [polypeptide binding]; other site 198094001862 putative DNA binding site [nucleotide binding]; other site 198094001863 putative Zn2+ binding site [ion binding]; other site 198094001864 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 198094001865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094001866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094001867 putative substrate translocation pore; other site 198094001868 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198094001869 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198094001870 siderophore binding site; other site 198094001871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094001872 ABC-ATPase subunit interface; other site 198094001873 dimer interface [polypeptide binding]; other site 198094001874 putative PBP binding regions; other site 198094001875 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094001876 ABC-ATPase subunit interface; other site 198094001877 dimer interface [polypeptide binding]; other site 198094001878 putative PBP binding regions; other site 198094001879 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198094001880 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198094001881 Walker A/P-loop; other site 198094001882 ATP binding site [chemical binding]; other site 198094001883 Q-loop/lid; other site 198094001884 ABC transporter signature motif; other site 198094001885 Walker B; other site 198094001886 D-loop; other site 198094001887 H-loop/switch region; other site 198094001888 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094001889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094001890 S-adenosylmethionine binding site [chemical binding]; other site 198094001891 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 198094001892 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 198094001893 substrate-cofactor binding pocket; other site 198094001894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094001895 catalytic residue [active] 198094001896 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198094001897 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 198094001898 NAD binding site [chemical binding]; other site 198094001899 homodimer interface [polypeptide binding]; other site 198094001900 active site 198094001901 putative substrate binding site [chemical binding]; other site 198094001902 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 198094001903 nudix motif; other site 198094001904 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 198094001905 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 198094001906 metal ion-dependent adhesion site (MIDAS); other site 198094001907 MoxR-like ATPases [General function prediction only]; Region: COG0714 198094001908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094001909 Walker A motif; other site 198094001910 ATP binding site [chemical binding]; other site 198094001911 Walker B motif; other site 198094001912 arginine finger; other site 198094001913 cardiolipin synthetase; Reviewed; Region: PRK12452 198094001914 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 198094001915 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 198094001916 putative active site [active] 198094001917 catalytic site [active] 198094001918 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 198094001919 putative active site [active] 198094001920 catalytic site [active] 198094001921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094001922 PAS domain; Region: PAS_9; pfam13426 198094001923 putative active site [active] 198094001924 heme pocket [chemical binding]; other site 198094001925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198094001926 metal binding site [ion binding]; metal-binding site 198094001927 active site 198094001928 I-site; other site 198094001929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198094001930 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 198094001931 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094001932 Spore germination protein; Region: Spore_permease; cl17796 198094001933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094001934 DNA-binding site [nucleotide binding]; DNA binding site 198094001935 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 198094001936 UTRA domain; Region: UTRA; pfam07702 198094001937 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 198094001938 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198094001939 active site turn [active] 198094001940 phosphorylation site [posttranslational modification] 198094001941 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198094001942 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 198094001943 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 198094001944 Ca binding site [ion binding]; other site 198094001945 active site 198094001946 catalytic site [active] 198094001947 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 198094001948 Spore germination protein; Region: Spore_permease; cl17796 198094001949 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 198094001950 CAAX protease self-immunity; Region: Abi; pfam02517 198094001951 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094001952 Phosphotransferase enzyme family; Region: APH; pfam01636 198094001953 active site 198094001954 ATP binding site [chemical binding]; other site 198094001955 substrate binding site [chemical binding]; other site 198094001956 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 198094001957 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 198094001958 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198094001959 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198094001960 Walker A/P-loop; other site 198094001961 ATP binding site [chemical binding]; other site 198094001962 Q-loop/lid; other site 198094001963 ABC transporter signature motif; other site 198094001964 Walker B; other site 198094001965 D-loop; other site 198094001966 H-loop/switch region; other site 198094001967 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 198094001968 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198094001969 substrate binding pocket [chemical binding]; other site 198094001970 membrane-bound complex binding site; other site 198094001971 hinge residues; other site 198094001972 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 198094001973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094001974 dimer interface [polypeptide binding]; other site 198094001975 conserved gate region; other site 198094001976 putative PBP binding loops; other site 198094001977 ABC-ATPase subunit interface; other site 198094001978 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 198094001979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094001980 dimer interface [polypeptide binding]; other site 198094001981 conserved gate region; other site 198094001982 putative PBP binding loops; other site 198094001983 ABC-ATPase subunit interface; other site 198094001984 S-methylmethionine transporter; Provisional; Region: PRK11387 198094001985 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094001986 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 198094001987 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 198094001988 nucleotide binding site/active site [active] 198094001989 HIT family signature motif; other site 198094001990 catalytic residue [active] 198094001991 RNA polymerase sigma factor; Provisional; Region: PRK12542 198094001992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094001993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094001994 DNA binding residues [nucleotide binding] 198094001995 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 198094001996 Predicted transcriptional regulator [Transcription]; Region: COG2378 198094001997 HTH domain; Region: HTH_11; pfam08279 198094001998 WYL domain; Region: WYL; pfam13280 198094001999 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 198094002000 folate binding site [chemical binding]; other site 198094002001 NADP+ binding site [chemical binding]; other site 198094002002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 198094002003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094002004 dimerization interface [polypeptide binding]; other site 198094002005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094002006 dimer interface [polypeptide binding]; other site 198094002007 phosphorylation site [posttranslational modification] 198094002008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094002009 ATP binding site [chemical binding]; other site 198094002010 Mg2+ binding site [ion binding]; other site 198094002011 G-X-G motif; other site 198094002012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094002013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094002014 active site 198094002015 phosphorylation site [posttranslational modification] 198094002016 intermolecular recognition site; other site 198094002017 dimerization interface [polypeptide binding]; other site 198094002018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094002019 DNA binding site [nucleotide binding] 198094002020 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 198094002021 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 198094002022 Sulfate transporter family; Region: Sulfate_transp; pfam00916 198094002023 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 198094002024 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198094002025 Ligand Binding Site [chemical binding]; other site 198094002026 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 198094002027 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198094002028 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 198094002029 peptide binding site [polypeptide binding]; other site 198094002030 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198094002031 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002033 dimer interface [polypeptide binding]; other site 198094002034 conserved gate region; other site 198094002035 putative PBP binding loops; other site 198094002036 ABC-ATPase subunit interface; other site 198094002037 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198094002038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002039 dimer interface [polypeptide binding]; other site 198094002040 conserved gate region; other site 198094002041 putative PBP binding loops; other site 198094002042 ABC-ATPase subunit interface; other site 198094002043 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198094002044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094002045 Walker A/P-loop; other site 198094002046 ATP binding site [chemical binding]; other site 198094002047 Q-loop/lid; other site 198094002048 ABC transporter signature motif; other site 198094002049 Walker B; other site 198094002050 D-loop; other site 198094002051 H-loop/switch region; other site 198094002052 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198094002053 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 198094002054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002055 putative substrate translocation pore; other site 198094002056 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094002057 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094002058 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094002059 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094002060 DNA binding site [nucleotide binding] 198094002061 domain linker motif; other site 198094002062 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 198094002063 dimerization interface [polypeptide binding]; other site 198094002064 ligand binding site [chemical binding]; other site 198094002065 sodium binding site [ion binding]; other site 198094002066 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 198094002067 substrate binding site [chemical binding]; other site 198094002068 dimer interface [polypeptide binding]; other site 198094002069 ATP binding site [chemical binding]; other site 198094002070 D-ribose pyranase; Provisional; Region: PRK11797 198094002071 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198094002072 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198094002073 Walker A/P-loop; other site 198094002074 ATP binding site [chemical binding]; other site 198094002075 Q-loop/lid; other site 198094002076 ABC transporter signature motif; other site 198094002077 Walker B; other site 198094002078 D-loop; other site 198094002079 H-loop/switch region; other site 198094002080 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198094002081 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198094002082 TM-ABC transporter signature motif; other site 198094002083 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 198094002084 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 198094002085 ligand binding site [chemical binding]; other site 198094002086 dimerization interface [polypeptide binding]; other site 198094002087 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 198094002088 active site 198094002089 intersubunit interactions; other site 198094002090 catalytic residue [active] 198094002091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 198094002092 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 198094002093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094002095 putative substrate translocation pore; other site 198094002096 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198094002097 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 198094002098 putative NAD(P) binding site [chemical binding]; other site 198094002099 catalytic Zn binding site [ion binding]; other site 198094002100 Ion channel; Region: Ion_trans_2; pfam07885 198094002101 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 198094002102 Zn binding site [ion binding]; other site 198094002103 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 198094002104 putative catalytic site [active] 198094002105 metal binding site A [ion binding]; metal-binding site 198094002106 phosphate binding site [ion binding]; other site 198094002107 metal binding site C [ion binding]; metal-binding site 198094002108 metal binding site B [ion binding]; metal-binding site 198094002109 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 198094002110 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 198094002111 dimer interface [polypeptide binding]; other site 198094002112 active site 198094002113 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198094002114 substrate binding site [chemical binding]; other site 198094002115 catalytic residue [active] 198094002116 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 198094002117 FAD binding domain; Region: FAD_binding_4; pfam01565 198094002118 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 198094002119 VanZ like family; Region: VanZ; pfam04892 198094002120 RDD family; Region: RDD; pfam06271 198094002121 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 198094002122 IncA protein; Region: IncA; pfam04156 198094002123 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094002124 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 198094002125 dimer interface [polypeptide binding]; other site 198094002126 putative CheW interface [polypeptide binding]; other site 198094002127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 198094002128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 198094002129 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094002130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094002131 non-specific DNA binding site [nucleotide binding]; other site 198094002132 salt bridge; other site 198094002133 sequence-specific DNA binding site [nucleotide binding]; other site 198094002134 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 198094002135 active site 198094002136 catalytic site [active] 198094002137 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 198094002138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002139 putative substrate translocation pore; other site 198094002140 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 198094002141 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 198094002142 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 198094002143 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 198094002144 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 198094002145 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198094002146 Sulfate transporter family; Region: Sulfate_transp; cl19250 198094002147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094002148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094002149 non-specific DNA binding site [nucleotide binding]; other site 198094002150 salt bridge; other site 198094002151 sequence-specific DNA binding site [nucleotide binding]; other site 198094002152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094002153 Coenzyme A binding pocket [chemical binding]; other site 198094002154 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 198094002155 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 198094002156 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 198094002157 TrkA-N domain; Region: TrkA_N; pfam02254 198094002158 TrkA-C domain; Region: TrkA_C; pfam02080 198094002159 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 198094002160 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 198094002161 Subunit I/III interface [polypeptide binding]; other site 198094002162 Subunit III/IV interface [polypeptide binding]; other site 198094002163 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 198094002164 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 198094002165 D-pathway; other site 198094002166 Putative ubiquinol binding site [chemical binding]; other site 198094002167 Low-spin heme (heme b) binding site [chemical binding]; other site 198094002168 Putative water exit pathway; other site 198094002169 Binuclear center (heme o3/CuB) [ion binding]; other site 198094002170 K-pathway; other site 198094002171 Putative proton exit pathway; other site 198094002172 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 198094002173 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 198094002174 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 198094002175 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 198094002176 putative active site [active] 198094002177 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198094002178 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 198094002179 metal binding site [ion binding]; metal-binding site 198094002180 dimer interface [polypeptide binding]; other site 198094002181 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 198094002182 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 198094002183 Na binding site [ion binding]; other site 198094002184 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 198094002185 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 198094002186 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 198094002187 FeoA domain; Region: FeoA; pfam04023 198094002188 phosphate binding protein; Region: ptsS_2; TIGR02136 198094002189 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 198094002190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002191 dimer interface [polypeptide binding]; other site 198094002192 conserved gate region; other site 198094002193 putative PBP binding loops; other site 198094002194 ABC-ATPase subunit interface; other site 198094002195 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 198094002196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002197 dimer interface [polypeptide binding]; other site 198094002198 conserved gate region; other site 198094002199 putative PBP binding loops; other site 198094002200 ABC-ATPase subunit interface; other site 198094002201 AAA domain; Region: AAA_17; cl19128 198094002202 AAA domain; Region: AAA_33; pfam13671 198094002203 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 198094002204 MMPL family; Region: MMPL; cl14618 198094002205 MMPL family; Region: MMPL; cl14618 198094002206 FOG: CBS domain [General function prediction only]; Region: COG0517 198094002207 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 198094002208 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 198094002209 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 198094002210 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094002211 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094002212 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094002213 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 198094002214 Peptidase family M23; Region: Peptidase_M23; pfam01551 198094002215 Putative transcription activator [Transcription]; Region: TenA; COG0819 198094002216 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198094002217 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198094002218 Walker A/P-loop; other site 198094002219 ATP binding site [chemical binding]; other site 198094002220 Q-loop/lid; other site 198094002221 ABC transporter signature motif; other site 198094002222 Walker B; other site 198094002223 D-loop; other site 198094002224 H-loop/switch region; other site 198094002225 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198094002226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002227 dimer interface [polypeptide binding]; other site 198094002228 conserved gate region; other site 198094002229 putative PBP binding loops; other site 198094002230 ABC-ATPase subunit interface; other site 198094002231 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 198094002232 NMT1/THI5 like; Region: NMT1; pfam09084 198094002233 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 198094002234 thiamine phosphate binding site [chemical binding]; other site 198094002235 active site 198094002236 pyrophosphate binding site [ion binding]; other site 198094002237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094002238 FAD dependent oxidoreductase; Region: DAO; pfam01266 198094002239 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 198094002240 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 198094002241 thiS-thiF/thiG interaction site; other site 198094002242 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 198094002243 ThiS interaction site; other site 198094002244 putative active site [active] 198094002245 tetramer interface [polypeptide binding]; other site 198094002246 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 198094002247 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198094002248 ATP binding site [chemical binding]; other site 198094002249 substrate interface [chemical binding]; other site 198094002250 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 198094002251 dimer interface [polypeptide binding]; other site 198094002252 substrate binding site [chemical binding]; other site 198094002253 ATP binding site [chemical binding]; other site 198094002254 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 198094002255 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 198094002256 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198094002257 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 198094002258 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 198094002259 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 198094002260 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 198094002261 Ligand Binding Site [chemical binding]; other site 198094002262 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 198094002263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002264 putative substrate translocation pore; other site 198094002265 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094002266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 198094002267 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 198094002268 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 198094002269 active site 198094002270 nucleophile elbow; other site 198094002271 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198094002272 oxidoreductase; Provisional; Region: PRK06128 198094002273 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 198094002274 NAD binding site [chemical binding]; other site 198094002275 metal binding site [ion binding]; metal-binding site 198094002276 active site 198094002277 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 198094002278 putative substrate binding site [chemical binding]; other site 198094002279 putative ATP binding site [chemical binding]; other site 198094002280 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 198094002281 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 198094002282 substrate binding [chemical binding]; other site 198094002283 active site 198094002284 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 198094002285 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 198094002286 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198094002287 active site turn [active] 198094002288 phosphorylation site [posttranslational modification] 198094002289 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198094002290 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094002291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094002292 DNA binding site [nucleotide binding] 198094002293 domain linker motif; other site 198094002294 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 198094002295 dimerization interface [polypeptide binding]; other site 198094002296 ligand binding site [chemical binding]; other site 198094002297 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198094002298 catalytic residues [active] 198094002299 putative disulfide oxidoreductase; Provisional; Region: PRK03113 198094002300 YhdB-like protein; Region: YhdB; pfam14148 198094002301 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 198094002302 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 198094002303 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 198094002304 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 198094002305 putative FMN binding site [chemical binding]; other site 198094002306 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 198094002307 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 198094002308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094002309 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094002310 putative DNA binding site [nucleotide binding]; other site 198094002311 putative Zn2+ binding site [ion binding]; other site 198094002312 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 198094002313 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 198094002314 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 198094002315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094002316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094002317 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 198094002318 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 198094002319 active site residue [active] 198094002320 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 198094002321 putative homodimer interface [polypeptide binding]; other site 198094002322 putative homotetramer interface [polypeptide binding]; other site 198094002323 putative metal binding site [ion binding]; other site 198094002324 putative homodimer-homodimer interface [polypeptide binding]; other site 198094002325 putative allosteric switch controlling residues; other site 198094002326 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 198094002327 CPxP motif; other site 198094002328 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198094002329 active site residue [active] 198094002330 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 198094002331 active site residue [active] 198094002332 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198094002333 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 198094002334 CPxP motif; other site 198094002335 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198094002336 active site residue [active] 198094002337 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198094002338 active site residue [active] 198094002339 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 198094002340 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198094002341 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 198094002342 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 198094002343 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 198094002344 NADP binding site [chemical binding]; other site 198094002345 dimer interface [polypeptide binding]; other site 198094002346 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 198094002347 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 198094002348 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 198094002349 PhoU domain; Region: PhoU; pfam01895 198094002350 PhoU domain; Region: PhoU; pfam01895 198094002351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094002353 putative substrate translocation pore; other site 198094002354 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 198094002355 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 198094002356 HTH domain; Region: HTH_11; pfam08279 198094002357 Mga helix-turn-helix domain; Region: Mga; pfam05043 198094002358 PRD domain; Region: PRD; pfam00874 198094002359 PRD domain; Region: PRD; pfam00874 198094002360 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 198094002361 active site 198094002362 P-loop; other site 198094002363 phosphorylation site [posttranslational modification] 198094002364 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198094002365 active site 198094002366 phosphorylation site [posttranslational modification] 198094002367 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 198094002368 active site 198094002369 methionine cluster; other site 198094002370 phosphorylation site [posttranslational modification] 198094002371 metal binding site [ion binding]; metal-binding site 198094002372 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 198094002373 active site 198094002374 P-loop; other site 198094002375 phosphorylation site [posttranslational modification] 198094002376 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 198094002377 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 198094002378 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094002379 Bacterial SH3 domain homologues; Region: SH3b; smart00287 198094002380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 198094002381 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198094002382 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094002383 FtsX-like permease family; Region: FtsX; pfam02687 198094002384 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094002385 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094002386 Walker A/P-loop; other site 198094002387 ATP binding site [chemical binding]; other site 198094002388 Q-loop/lid; other site 198094002389 ABC transporter signature motif; other site 198094002390 Walker B; other site 198094002391 D-loop; other site 198094002392 H-loop/switch region; other site 198094002393 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198094002394 HlyD family secretion protein; Region: HlyD_3; pfam13437 198094002395 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 198094002396 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094002397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002398 dimer interface [polypeptide binding]; other site 198094002399 conserved gate region; other site 198094002400 ABC-ATPase subunit interface; other site 198094002401 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 198094002402 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 198094002403 dimanganese center [ion binding]; other site 198094002404 CotJB protein; Region: CotJB; pfam12652 198094002405 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 198094002406 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 198094002407 active site 198094002408 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 198094002409 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 198094002410 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 198094002411 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 198094002412 putative DNA binding site [nucleotide binding]; other site 198094002413 putative homodimer interface [polypeptide binding]; other site 198094002414 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 198094002415 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198094002416 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 198094002417 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 198094002418 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 198094002419 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 198094002420 active site 198094002421 metal binding site [ion binding]; metal-binding site 198094002422 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198094002423 Interdomain contacts; other site 198094002424 Cytokine receptor motif; other site 198094002425 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 198094002426 amino acid transporter; Region: 2A0306; TIGR00909 198094002427 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094002428 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 198094002429 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 198094002430 DNA topoisomerase VI, subunit B [DNA replication, recombination, and repair]; Region: COG1389 198094002431 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 198094002432 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198094002433 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198094002434 putative active site [active] 198094002435 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 198094002436 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 198094002437 putative active site [active] 198094002438 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198094002439 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 198094002440 active site turn [active] 198094002441 phosphorylation site [posttranslational modification] 198094002442 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198094002443 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 198094002444 DoxX; Region: DoxX; pfam07681 198094002445 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 198094002446 hypothetical protein; Provisional; Region: PRK06770 198094002447 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094002448 EamA-like transporter family; Region: EamA; pfam00892 198094002449 EamA-like transporter family; Region: EamA; pfam00892 198094002450 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198094002451 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 198094002452 putative DNA binding site [nucleotide binding]; other site 198094002453 putative Zn2+ binding site [ion binding]; other site 198094002454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094002455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094002456 Coenzyme A binding pocket [chemical binding]; other site 198094002457 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 198094002458 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 198094002459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094002460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094002461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094002463 putative substrate translocation pore; other site 198094002464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094002465 putative DNA binding site [nucleotide binding]; other site 198094002466 putative Zn2+ binding site [ion binding]; other site 198094002467 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 198094002468 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 198094002469 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 198094002470 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 198094002471 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 198094002472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094002473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002474 putative substrate translocation pore; other site 198094002475 intracellular protease, PfpI family; Region: PfpI; TIGR01382 198094002476 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 198094002477 proposed catalytic triad [active] 198094002478 conserved cys residue [active] 198094002479 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 198094002480 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 198094002481 tetramer interface [polypeptide binding]; other site 198094002482 heme binding pocket [chemical binding]; other site 198094002483 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 198094002484 conserved cys residue [active] 198094002485 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 198094002486 arginine:agmatin antiporter; Provisional; Region: PRK10644 198094002487 Spore germination protein; Region: Spore_permease; cl17796 198094002488 glutamate racemase; Provisional; Region: PRK00865 198094002489 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 198094002490 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 198094002491 tetrameric interface [polypeptide binding]; other site 198094002492 activator binding site; other site 198094002493 NADP binding site [chemical binding]; other site 198094002494 substrate binding site [chemical binding]; other site 198094002495 catalytic residues [active] 198094002496 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094002497 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 198094002498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094002499 Walker A/P-loop; other site 198094002500 ATP binding site [chemical binding]; other site 198094002501 Q-loop/lid; other site 198094002502 ABC transporter signature motif; other site 198094002503 Walker B; other site 198094002504 D-loop; other site 198094002505 H-loop/switch region; other site 198094002506 cystine transporter subunit; Provisional; Region: PRK11260 198094002507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198094002508 substrate binding pocket [chemical binding]; other site 198094002509 membrane-bound complex binding site; other site 198094002510 hinge residues; other site 198094002511 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 198094002512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002513 dimer interface [polypeptide binding]; other site 198094002514 conserved gate region; other site 198094002515 putative PBP binding loops; other site 198094002516 ABC-ATPase subunit interface; other site 198094002517 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198094002518 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198094002519 Walker A/P-loop; other site 198094002520 ATP binding site [chemical binding]; other site 198094002521 Q-loop/lid; other site 198094002522 ABC transporter signature motif; other site 198094002523 Walker B; other site 198094002524 D-loop; other site 198094002525 H-loop/switch region; other site 198094002526 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 198094002527 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 198094002528 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 198094002529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 198094002530 Protein of unknown function (DUF445); Region: DUF445; pfam04286 198094002531 hypothetical protein; Provisional; Region: PRK13676 198094002532 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 198094002533 acetolactate synthase; Reviewed; Region: PRK08617 198094002534 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198094002535 PYR/PP interface [polypeptide binding]; other site 198094002536 dimer interface [polypeptide binding]; other site 198094002537 TPP binding site [chemical binding]; other site 198094002538 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198094002539 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 198094002540 TPP-binding site [chemical binding]; other site 198094002541 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 198094002542 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 198094002543 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 198094002544 active site 198094002545 DNA binding site [nucleotide binding] 198094002546 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 198094002547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094002548 active site 198094002549 motif I; other site 198094002550 motif II; other site 198094002551 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094002552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094002553 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 198094002554 Cna protein B-type domain; Region: Cna_B; pfam05738 198094002555 Cna protein B-type domain; Region: Cna_B; pfam05738 198094002556 Cna protein B-type domain; Region: Cna_B; pfam05738 198094002557 Cna protein B-type domain; Region: Cna_B; pfam05738 198094002558 Cna protein B-type domain; Region: Cna_B; pfam05738 198094002559 WTX protein; Region: WTX; pfam09422 198094002560 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 198094002561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094002562 FeS/SAM binding site; other site 198094002563 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 198094002564 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 198094002565 acyl-activating enzyme (AAE) consensus motif; other site 198094002566 putative AMP binding site [chemical binding]; other site 198094002567 putative active site [active] 198094002568 putative CoA binding site [chemical binding]; other site 198094002569 high affinity sulphate transporter 1; Region: sulP; TIGR00815 198094002570 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 198094002571 Sulfate transporter family; Region: Sulfate_transp; cl19250 198094002572 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 198094002573 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 198094002574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094002575 ATP binding site [chemical binding]; other site 198094002576 putative Mg++ binding site [ion binding]; other site 198094002577 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 198094002578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094002579 nucleotide binding region [chemical binding]; other site 198094002580 ATP-binding site [chemical binding]; other site 198094002581 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 198094002582 stage V sporulation protein B; Region: spore_V_B; TIGR02900 198094002583 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 198094002584 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 198094002585 S-layer homology domain; Region: SLH; pfam00395 198094002586 S-layer homology domain; Region: SLH; pfam00395 198094002587 S-layer homology domain; Region: SLH; pfam00395 198094002588 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 198094002589 S-layer homology domain; Region: SLH; pfam00395 198094002590 S-layer homology domain; Region: SLH; pfam00395 198094002591 S-layer homology domain; Region: SLH; pfam00395 198094002592 DHHW protein; Region: DHHW; pfam14286 198094002593 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 198094002594 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 198094002595 enoyl-CoA hydratase; Provisional; Region: PRK07659 198094002596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198094002597 substrate binding site [chemical binding]; other site 198094002598 oxyanion hole (OAH) forming residues; other site 198094002599 trimer interface [polypeptide binding]; other site 198094002600 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 198094002601 metal binding site [ion binding]; metal-binding site 198094002602 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 198094002603 putative oligomer interface [polypeptide binding]; other site 198094002604 putative active site [active] 198094002605 metal binding site [ion binding]; metal-binding site 198094002606 S-layer homology domain; Region: SLH; pfam00395 198094002607 S-layer homology domain; Region: SLH; pfam00395 198094002608 S-layer homology domain; Region: SLH; pfam00395 198094002609 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 198094002610 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198094002611 active site 198094002612 metal binding site [ion binding]; metal-binding site 198094002613 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 198094002614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094002615 S-adenosylmethionine binding site [chemical binding]; other site 198094002616 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 198094002617 proline racemase; Provisional; Region: PRK13969 198094002618 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 198094002619 ornithine cyclodeaminase; Validated; Region: PRK08618 198094002620 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 198094002621 Yip1 domain; Region: Yip1; pfam04893 198094002622 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198094002623 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 198094002624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198094002625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002626 dimer interface [polypeptide binding]; other site 198094002627 conserved gate region; other site 198094002628 putative PBP binding loops; other site 198094002629 ABC-ATPase subunit interface; other site 198094002630 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094002631 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198094002632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094002633 dimer interface [polypeptide binding]; other site 198094002634 conserved gate region; other site 198094002635 putative PBP binding loops; other site 198094002636 ABC-ATPase subunit interface; other site 198094002637 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 198094002638 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094002639 Walker A/P-loop; other site 198094002640 ATP binding site [chemical binding]; other site 198094002641 Q-loop/lid; other site 198094002642 ABC transporter signature motif; other site 198094002643 Walker B; other site 198094002644 D-loop; other site 198094002645 H-loop/switch region; other site 198094002646 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094002647 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 198094002648 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 198094002649 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 198094002650 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 198094002651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002652 putative substrate translocation pore; other site 198094002653 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 198094002654 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 198094002655 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094002656 putative active site [active] 198094002657 heme pocket [chemical binding]; other site 198094002658 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 198094002659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094002660 ATP binding site [chemical binding]; other site 198094002661 Mg2+ binding site [ion binding]; other site 198094002662 G-X-G motif; other site 198094002663 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 198094002664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094002665 active site 198094002666 phosphorylation site [posttranslational modification] 198094002667 intermolecular recognition site; other site 198094002668 dimerization interface [polypeptide binding]; other site 198094002669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 198094002670 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 198094002671 putative metal binding site [ion binding]; other site 198094002672 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 198094002673 putative metal binding site [ion binding]; other site 198094002674 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 198094002675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 198094002676 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 198094002677 Protein of unknown function (DUF524); Region: DUF524; pfam04411 198094002678 Tic20-like protein; Region: Tic20; pfam09685 198094002679 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 198094002680 DNA binding residues [nucleotide binding] 198094002681 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094002682 dimer interface [polypeptide binding]; other site 198094002683 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 198094002684 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 198094002685 replicative DNA helicase; Provisional; Region: PRK06749 198094002686 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 198094002687 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 198094002688 Walker A motif; other site 198094002689 ATP binding site [chemical binding]; other site 198094002690 Walker B motif; other site 198094002691 DNA binding loops [nucleotide binding] 198094002692 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 198094002693 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 198094002694 Predicted transcriptional regulators [Transcription]; Region: COG1378 198094002695 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 198094002696 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 198094002697 C-terminal domain interface [polypeptide binding]; other site 198094002698 sugar binding site [chemical binding]; other site 198094002699 hypothetical protein; Provisional; Region: PRK10621 198094002700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094002701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094002702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094002704 putative substrate translocation pore; other site 198094002705 Predicted permease; Region: DUF318; cl17795 198094002706 Predicted permease; Region: DUF318; cl17795 198094002707 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 198094002708 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 198094002709 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 198094002710 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 198094002711 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 198094002712 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 198094002713 CGNR zinc finger; Region: zf-CGNR; pfam11706 198094002714 HPP family; Region: HPP; pfam04982 198094002715 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 198094002716 Male sterility protein; Region: NAD_binding_4; pfam07993 198094002717 putative NAD(P) binding site [chemical binding]; other site 198094002718 active site 198094002719 putative substrate binding site [chemical binding]; other site 198094002720 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094002721 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094002722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094002723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094002724 YmzC-like protein; Region: YmzC; pfam14157 198094002725 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 198094002726 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094002727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 198094002728 putative DNA binding site [nucleotide binding]; other site 198094002729 putative Zn2+ binding site [ion binding]; other site 198094002730 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 198094002731 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 198094002732 ATP synthase I chain; Region: ATP_synt_I; pfam03899 198094002733 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 198094002734 VanZ like family; Region: VanZ; pfam04892 198094002735 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 198094002736 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 198094002737 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 198094002738 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 198094002739 dihydroxyacetone kinase; Provisional; Region: PRK14479 198094002740 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 198094002741 DAK2 domain; Region: Dak2; pfam02734 198094002742 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 198094002743 Predicted transcriptional regulator [Transcription]; Region: COG1959 198094002744 Rrf2 family protein; Region: rrf2_super; TIGR00738 198094002745 CAAX protease self-immunity; Region: Abi; pfam02517 198094002746 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 198094002747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094002748 Zn2+ binding site [ion binding]; other site 198094002749 Mg2+ binding site [ion binding]; other site 198094002750 S-layer homology domain; Region: SLH; pfam00395 198094002751 S-layer homology domain; Region: SLH; pfam00395 198094002752 S-layer homology domain; Region: SLH; pfam00395 198094002753 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 198094002754 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094002755 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 198094002756 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 198094002757 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 198094002758 Heat induced stress protein YflT; Region: YflT; pfam11181 198094002759 CsbD-like; Region: CsbD; pfam05532 198094002760 Predicted membrane protein [Function unknown]; Region: COG2261 198094002761 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 198094002762 anti sigma factor interaction site; other site 198094002763 regulatory phosphorylation site [posttranslational modification]; other site 198094002764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094002765 ATP binding site [chemical binding]; other site 198094002766 Mg2+ binding site [ion binding]; other site 198094002767 G-X-G motif; other site 198094002768 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 198094002769 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094002770 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198094002771 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094002772 DNA binding residues [nucleotide binding] 198094002773 Ferritin-like domain; Region: Ferritin; pfam00210 198094002774 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 198094002775 dinuclear metal binding motif [ion binding]; other site 198094002776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094002777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094002778 active site 198094002779 phosphorylation site [posttranslational modification] 198094002780 intermolecular recognition site; other site 198094002781 dimerization interface [polypeptide binding]; other site 198094002782 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 198094002783 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 198094002784 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 198094002785 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 198094002786 CHASE3 domain; Region: CHASE3; pfam05227 198094002787 HAMP domain; Region: HAMP; pfam00672 198094002788 GAF domain; Region: GAF_2; pfam13185 198094002789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094002790 Borna disease virus P24 protein; Region: BDV_P24; pfam06595 198094002791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094002792 dimer interface [polypeptide binding]; other site 198094002793 phosphorylation site [posttranslational modification] 198094002794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094002795 ATP binding site [chemical binding]; other site 198094002796 Mg2+ binding site [ion binding]; other site 198094002797 G-X-G motif; other site 198094002798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094002799 active site 198094002800 phosphorylation site [posttranslational modification] 198094002801 intermolecular recognition site; other site 198094002802 dimerization interface [polypeptide binding]; other site 198094002803 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 198094002804 Heat induced stress protein YflT; Region: YflT; pfam11181 198094002805 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 198094002806 hypothetical protein; Provisional; Region: PRK12856 198094002807 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 198094002808 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198094002809 NADP binding site [chemical binding]; other site 198094002810 dimer interface [polypeptide binding]; other site 198094002811 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 198094002812 YhzD-like protein; Region: YhzD; pfam14120 198094002813 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 198094002814 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 198094002815 active site 198094002816 metal binding site [ion binding]; metal-binding site 198094002817 DNA binding site [nucleotide binding] 198094002818 AAA domain; Region: AAA_23; pfam13476 198094002819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 198094002820 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 198094002821 Probable transposase; Region: OrfB_IS605; pfam01385 198094002822 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 198094002823 AAA domain; Region: AAA_27; pfam13514 198094002824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094002825 Q-loop/lid; other site 198094002826 ABC transporter signature motif; other site 198094002827 Walker B; other site 198094002828 D-loop; other site 198094002829 H-loop/switch region; other site 198094002830 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 198094002831 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 198094002832 generic binding surface II; other site 198094002833 generic binding surface I; other site 198094002834 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094002835 Zn2+ binding site [ion binding]; other site 198094002836 Mg2+ binding site [ion binding]; other site 198094002837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094002838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094002839 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198094002840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002841 putative substrate translocation pore; other site 198094002842 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 198094002843 Zn binding site [ion binding]; other site 198094002844 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 198094002845 Zn binding site [ion binding]; other site 198094002846 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 198094002847 Zn binding site [ion binding]; other site 198094002848 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 198094002849 Zn binding site [ion binding]; other site 198094002850 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198094002851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094002852 TPR motif; other site 198094002853 binding surface 198094002854 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094002855 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094002856 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 198094002857 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 198094002858 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 198094002859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094002860 non-specific DNA binding site [nucleotide binding]; other site 198094002861 salt bridge; other site 198094002862 sequence-specific DNA binding site [nucleotide binding]; other site 198094002863 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 198094002864 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 198094002865 amphipathic channel; other site 198094002866 Asn-Pro-Ala signature motifs; other site 198094002867 glycerol kinase; Provisional; Region: glpK; PRK00047 198094002868 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 198094002869 N- and C-terminal domain interface [polypeptide binding]; other site 198094002870 active site 198094002871 MgATP binding site [chemical binding]; other site 198094002872 catalytic site [active] 198094002873 metal binding site [ion binding]; metal-binding site 198094002874 glycerol binding site [chemical binding]; other site 198094002875 homotetramer interface [polypeptide binding]; other site 198094002876 homodimer interface [polypeptide binding]; other site 198094002877 FBP binding site [chemical binding]; other site 198094002878 protein IIAGlc interface [polypeptide binding]; other site 198094002879 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 198094002880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094002881 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 198094002882 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 198094002883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094002884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094002885 DNA binding residues [nucleotide binding] 198094002886 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 198094002887 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 198094002888 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094002889 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094002890 DoxX-like family; Region: DoxX_2; pfam13564 198094002891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094002893 putative substrate translocation pore; other site 198094002894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094002895 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094002896 putative substrate translocation pore; other site 198094002897 Putative integral membrane protein DUF46; Region: DUF46; cl17511 198094002898 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 198094002899 Part of AAA domain; Region: AAA_19; pfam13245 198094002900 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198094002901 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 198094002902 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 198094002903 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198094002904 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 198094002905 transcriptional regulator Hpr; Provisional; Region: PRK13777 198094002906 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094002907 YtxH-like protein; Region: YtxH; cl02079 198094002908 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 198094002909 HIT family signature motif; other site 198094002910 catalytic residue [active] 198094002911 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 198094002912 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094002913 Walker A/P-loop; other site 198094002914 ATP binding site [chemical binding]; other site 198094002915 Q-loop/lid; other site 198094002916 ABC transporter signature motif; other site 198094002917 Walker B; other site 198094002918 D-loop; other site 198094002919 H-loop/switch region; other site 198094002920 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 198094002921 EcsC protein family; Region: EcsC; pfam12787 198094002922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094002923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094002924 Bacterial PH domain; Region: bPH_2; cl01348 198094002925 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 198094002926 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 198094002927 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 198094002928 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094002929 DNA binding residues [nucleotide binding] 198094002930 drug binding residues [chemical binding]; other site 198094002931 dimer interface [polypeptide binding]; other site 198094002932 Bacterial PH domain; Region: bPH_2; cl01348 198094002933 Predicted membrane protein [Function unknown]; Region: COG3428 198094002934 Bacterial PH domain; Region: bPH_2; pfam03703 198094002935 Bacterial PH domain; Region: bPH_2; pfam03703 198094002936 Bacterial PH domain; Region: bPH_2; pfam03703 198094002937 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 198094002938 Transglycosylase; Region: Transgly; pfam00912 198094002939 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 198094002940 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094002941 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 198094002942 substrate binding site [chemical binding]; other site 198094002943 active site 198094002944 ferrochelatase; Provisional; Region: PRK12435 198094002945 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 198094002946 C-terminal domain interface [polypeptide binding]; other site 198094002947 active site 198094002948 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 198094002949 active site 198094002950 N-terminal domain interface [polypeptide binding]; other site 198094002951 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 198094002952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198094002953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094002954 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 198094002955 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl19625 198094002956 Fn3 associated; Region: Fn3_assoc; pfam13287 198094002957 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 198094002958 generic binding surface II; other site 198094002959 generic binding surface I; other site 198094002960 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 198094002961 putative active site [active] 198094002962 putative catalytic site [active] 198094002963 putative Mg binding site IVb [ion binding]; other site 198094002964 putative phosphate binding site [ion binding]; other site 198094002965 putative DNA binding site [nucleotide binding]; other site 198094002966 putative Mg binding site IVa [ion binding]; other site 198094002967 Penicillinase repressor; Region: Penicillinase_R; pfam03965 198094002968 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 198094002969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094002970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094002971 Predicted membrane protein [Function unknown]; Region: COG1511 198094002972 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 198094002973 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 198094002974 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094002975 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 198094002976 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 198094002977 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 198094002978 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 198094002979 Bacterial PH domain; Region: bPH_3; pfam14470 198094002980 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094002981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094002982 Coenzyme A binding pocket [chemical binding]; other site 198094002983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094002984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094002985 DNA binding site [nucleotide binding] 198094002986 domain linker motif; other site 198094002987 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 198094002988 putative dimerization interface [polypeptide binding]; other site 198094002989 putative ligand binding site [chemical binding]; other site 198094002990 YhfH-like protein; Region: YhfH; pfam14149 198094002991 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 198094002992 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 198094002993 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 198094002994 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 198094002995 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 198094002996 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 198094002997 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 198094002998 acyl-activating enzyme (AAE) consensus motif; other site 198094002999 putative AMP binding site [chemical binding]; other site 198094003000 putative active site [active] 198094003001 putative CoA binding site [chemical binding]; other site 198094003002 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094003003 heme-binding site [chemical binding]; other site 198094003004 S-layer homology domain; Region: SLH; pfam00395 198094003005 S-layer homology domain; Region: SLH; pfam00395 198094003006 S-layer homology domain; Region: SLH; pfam00395 198094003007 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198094003008 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 198094003009 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198094003010 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 198094003011 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198094003012 RHS Repeat; Region: RHS_repeat; pfam05593 198094003013 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 198094003014 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 198094003015 RHS protein; Region: RHS; pfam03527 198094003016 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198094003017 Aureocin-like type II bacteriocin; Region: Bacteriocin_IIi; pfam11758 198094003018 Regulator of ribonuclease activity B; Region: RraB; pfam06877 198094003019 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198094003020 RHS protein; Region: RHS; pfam03527 198094003021 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198094003022 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 198094003023 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 198094003024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094003025 Zn2+ binding site [ion binding]; other site 198094003026 Mg2+ binding site [ion binding]; other site 198094003027 Putative zinc-finger; Region: zf-HC2; pfam13490 198094003028 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 198094003029 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 198094003030 RNA polymerase sigma factor; Provisional; Region: PRK12541 198094003031 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094003032 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094003033 DNA binding residues [nucleotide binding] 198094003034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094003035 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198094003036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094003037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 198094003038 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 198094003039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094003040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094003041 dimer interface [polypeptide binding]; other site 198094003042 phosphorylation site [posttranslational modification] 198094003043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094003044 ATP binding site [chemical binding]; other site 198094003045 Mg2+ binding site [ion binding]; other site 198094003046 G-X-G motif; other site 198094003047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094003048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094003049 active site 198094003050 phosphorylation site [posttranslational modification] 198094003051 intermolecular recognition site; other site 198094003052 dimerization interface [polypeptide binding]; other site 198094003053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094003054 DNA binding site [nucleotide binding] 198094003055 CAAX protease self-immunity; Region: Abi; pfam02517 198094003056 Peptidase family M48; Region: Peptidase_M48; pfam01435 198094003057 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198094003058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094003059 dimerization interface [polypeptide binding]; other site 198094003060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094003061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198094003062 dimer interface [polypeptide binding]; other site 198094003063 putative CheW interface [polypeptide binding]; other site 198094003064 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094003065 EamA-like transporter family; Region: EamA; pfam00892 198094003066 EamA-like transporter family; Region: EamA; pfam00892 198094003067 S-layer homology domain; Region: SLH; pfam00395 198094003068 S-layer homology domain; Region: SLH; pfam00395 198094003069 S-layer homology domain; Region: SLH; pfam00395 198094003070 S-layer homology domain; Region: SLH; pfam00395 198094003071 S-layer homology domain; Region: SLH; pfam00395 198094003072 S-layer homology domain; Region: SLH; pfam00395 198094003073 S-layer homology domain; Region: SLH; pfam00395 198094003074 S-layer homology domain; Region: SLH; pfam00395 198094003075 S-layer homology domain; Region: SLH; pfam00395 198094003076 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 198094003077 active site 198094003078 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 198094003079 tetramer interface [polypeptide binding]; other site 198094003080 active site 198094003081 Mg2+/Mn2+ binding site [ion binding]; other site 198094003082 Phosphotransferase enzyme family; Region: APH; pfam01636 198094003083 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 198094003084 active site 198094003085 substrate binding site [chemical binding]; other site 198094003086 ATP binding site [chemical binding]; other site 198094003087 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198094003088 DNA-binding site [nucleotide binding]; DNA binding site 198094003089 RNA-binding motif; other site 198094003090 ComK protein; Region: ComK; pfam06338 198094003091 Uncharacterized conserved protein [Function unknown]; Region: COG0398 198094003092 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 198094003093 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198094003094 Catalytic site [active] 198094003095 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 198094003096 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 198094003097 AAA domain; Region: AAA_22; pfam13401 198094003098 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 198094003099 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 198094003100 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 198094003101 Part of AAA domain; Region: AAA_19; pfam13245 198094003102 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198094003103 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 198094003104 hypothetical protein; Provisional; Region: PRK07758 198094003105 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 198094003106 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 198094003107 Spore germination protein GerPC; Region: GerPC; pfam10737 198094003108 Spore germination GerPB; Region: GerPB; pfam10803 198094003109 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 198094003110 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 198094003111 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 198094003112 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094003113 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198094003114 inhibitor-cofactor binding pocket; inhibition site 198094003115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094003116 catalytic residue [active] 198094003117 hypothetical protein; Provisional; Region: PRK13673 198094003118 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 198094003119 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 198094003120 active site 198094003121 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 198094003122 dimer interface [polypeptide binding]; other site 198094003123 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 198094003124 Ligand Binding Site [chemical binding]; other site 198094003125 Molecular Tunnel; other site 198094003126 ferrochelatase; Provisional; Region: PRK12435 198094003127 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 198094003128 C-terminal domain interface [polypeptide binding]; other site 198094003129 active site 198094003130 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 198094003131 active site 198094003132 N-terminal domain interface [polypeptide binding]; other site 198094003133 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 198094003134 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 198094003135 tetramer interface [polypeptide binding]; other site 198094003136 heme binding pocket [chemical binding]; other site 198094003137 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 198094003138 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 198094003139 active site 198094003140 catalytic site [active] 198094003141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094003142 non-specific DNA binding site [nucleotide binding]; other site 198094003143 salt bridge; other site 198094003144 sequence-specific DNA binding site [nucleotide binding]; other site 198094003145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094003146 binding surface 198094003147 TPR motif; other site 198094003148 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198094003149 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 198094003150 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 198094003151 S1 domain; Region: S1_2; pfam13509 198094003152 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 198094003153 SurA N-terminal domain; Region: SurA_N_3; cl07813 198094003154 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198094003155 Domain of unknown function (DUF3941); Region: DUF3941; pfam13081 198094003156 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094003157 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094003158 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094003159 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094003160 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 198094003161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094003162 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 198094003163 active site 198094003164 motif I; other site 198094003165 motif II; other site 198094003166 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094003167 YjzC-like protein; Region: YjzC; pfam14168 198094003168 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 198094003169 Clp amino terminal domain; Region: Clp_N; pfam02861 198094003170 Clp amino terminal domain; Region: Clp_N; pfam02861 198094003171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094003172 Walker A motif; other site 198094003173 ATP binding site [chemical binding]; other site 198094003174 Walker B motif; other site 198094003175 arginine finger; other site 198094003176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094003177 Walker A motif; other site 198094003178 ATP binding site [chemical binding]; other site 198094003179 Walker B motif; other site 198094003180 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 198094003181 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 198094003182 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 198094003183 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 198094003184 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 198094003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094003186 NAD(P) binding site [chemical binding]; other site 198094003187 active site 198094003188 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 198094003189 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 198094003190 dimer interface [polypeptide binding]; other site 198094003191 active site 198094003192 CoA binding pocket [chemical binding]; other site 198094003193 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 198094003194 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 198094003195 dimer interface [polypeptide binding]; other site 198094003196 active site 198094003197 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 198094003198 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 198094003199 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 198094003200 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 198094003201 active site 198094003202 HIGH motif; other site 198094003203 dimer interface [polypeptide binding]; other site 198094003204 KMSKS motif; other site 198094003205 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 198094003206 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094003207 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094003208 peptide binding site [polypeptide binding]; other site 198094003209 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198094003210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094003211 dimer interface [polypeptide binding]; other site 198094003212 conserved gate region; other site 198094003213 putative PBP binding loops; other site 198094003214 ABC-ATPase subunit interface; other site 198094003215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094003216 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198094003217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094003218 dimer interface [polypeptide binding]; other site 198094003219 conserved gate region; other site 198094003220 putative PBP binding loops; other site 198094003221 ABC-ATPase subunit interface; other site 198094003222 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198094003223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094003224 Walker A/P-loop; other site 198094003225 ATP binding site [chemical binding]; other site 198094003226 Q-loop/lid; other site 198094003227 ABC transporter signature motif; other site 198094003228 Walker B; other site 198094003229 D-loop; other site 198094003230 H-loop/switch region; other site 198094003231 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094003232 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198094003233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094003234 Walker A/P-loop; other site 198094003235 ATP binding site [chemical binding]; other site 198094003236 Q-loop/lid; other site 198094003237 ABC transporter signature motif; other site 198094003238 Walker B; other site 198094003239 D-loop; other site 198094003240 H-loop/switch region; other site 198094003241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094003242 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 198094003243 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 198094003244 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094003245 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094003246 peptide binding site [polypeptide binding]; other site 198094003247 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 198094003248 putative catalytic residues [active] 198094003249 thiol/disulfide switch; other site 198094003250 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 198094003251 adaptor protein; Provisional; Region: PRK02315 198094003252 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 198094003253 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 198094003254 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 198094003255 putative active site [active] 198094003256 catalytic site [active] 198094003257 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 198094003258 putative active site [active] 198094003259 catalytic site [active] 198094003260 Competence protein CoiA-like family; Region: CoiA; cl11541 198094003261 oligoendopeptidase F; Region: pepF; TIGR00181 198094003262 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 198094003263 active site 198094003264 Zn binding site [ion binding]; other site 198094003265 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 198094003266 catalytic residues [active] 198094003267 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 198094003268 apolar tunnel; other site 198094003269 heme binding site [chemical binding]; other site 198094003270 dimerization interface [polypeptide binding]; other site 198094003271 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 198094003272 putative active site [active] 198094003273 putative metal binding residues [ion binding]; other site 198094003274 signature motif; other site 198094003275 putative triphosphate binding site [ion binding]; other site 198094003276 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198094003277 synthetase active site [active] 198094003278 NTP binding site [chemical binding]; other site 198094003279 metal binding site [ion binding]; metal-binding site 198094003280 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 198094003281 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 198094003282 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198094003283 active site 198094003284 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 198094003285 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 198094003286 active site 198094003287 metal binding site [ion binding]; metal-binding site 198094003288 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198094003289 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 198094003290 active site 198094003291 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094003292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094003293 S-adenosylmethionine binding site [chemical binding]; other site 198094003294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198094003295 exosporium leader peptide; Region: exospor_lead; TIGR03720 198094003296 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 198094003297 putative metal binding site; other site 198094003298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094003299 binding surface 198094003300 TPR motif; other site 198094003301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094003302 binding surface 198094003303 TPR motif; other site 198094003304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094003305 S-adenosylmethionine binding site [chemical binding]; other site 198094003306 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 198094003307 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 198094003308 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094003309 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 198094003310 active site 198094003311 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 198094003312 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 198094003313 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 198094003314 NAD binding site [chemical binding]; other site 198094003315 substrate binding site [chemical binding]; other site 198094003316 homodimer interface [polypeptide binding]; other site 198094003317 active site 198094003318 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 198094003319 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 198094003320 NADP binding site [chemical binding]; other site 198094003321 active site 198094003322 putative substrate binding site [chemical binding]; other site 198094003323 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 198094003324 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 198094003325 NAD binding site [chemical binding]; other site 198094003326 homotetramer interface [polypeptide binding]; other site 198094003327 homodimer interface [polypeptide binding]; other site 198094003328 substrate binding site [chemical binding]; other site 198094003329 active site 198094003330 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 198094003331 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 198094003332 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 198094003333 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 198094003334 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 198094003335 Part of AAA domain; Region: AAA_19; pfam13245 198094003336 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198094003337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094003338 Coenzyme A binding pocket [chemical binding]; other site 198094003339 hypothetical protein; Provisional; Region: PRK13679 198094003340 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198094003341 Putative esterase; Region: Esterase; pfam00756 198094003342 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 198094003343 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094003344 EamA-like transporter family; Region: EamA; pfam00892 198094003345 EamA-like transporter family; Region: EamA; pfam00892 198094003346 Bacterial PH domain; Region: bPH_4; pfam06713 198094003347 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 198094003348 Pectate lyase; Region: Pectate_lyase; pfam03211 198094003349 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 198094003350 Na binding site [ion binding]; other site 198094003351 anthranilate synthase component I; Provisional; Region: PRK13570 198094003352 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 198094003353 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 198094003354 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 198094003355 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 198094003356 glutamine binding [chemical binding]; other site 198094003357 catalytic triad [active] 198094003358 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 198094003359 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198094003360 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198094003361 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 198094003362 active site 198094003363 ribulose/triose binding site [chemical binding]; other site 198094003364 phosphate binding site [ion binding]; other site 198094003365 substrate (anthranilate) binding pocket [chemical binding]; other site 198094003366 product (indole) binding pocket [chemical binding]; other site 198094003367 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 198094003368 active site 198094003369 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 198094003370 cysteine synthase; Region: PLN02565 198094003371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094003372 catalytic residue [active] 198094003373 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 198094003374 substrate binding site [chemical binding]; other site 198094003375 active site 198094003376 catalytic residues [active] 198094003377 heterodimer interface [polypeptide binding]; other site 198094003378 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 198094003379 L-lactate permease; Region: Lactate_perm; cl00701 198094003380 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 198094003381 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 198094003382 Double zinc ribbon; Region: DZR; pfam12773 198094003383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094003384 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 198094003385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094003386 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 198094003387 Predicted acetyltransferase [General function prediction only]; Region: COG5628 198094003388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094003389 Coenzyme A binding pocket [chemical binding]; other site 198094003390 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 198094003391 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 198094003392 NADPH bind site [chemical binding]; other site 198094003393 putative FMN binding site [chemical binding]; other site 198094003394 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 198094003395 putative FMN binding site [chemical binding]; other site 198094003396 NADPH bind site [chemical binding]; other site 198094003397 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 198094003398 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 198094003399 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 198094003400 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 198094003401 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 198094003402 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198094003403 E3 interaction surface; other site 198094003404 lipoyl attachment site [posttranslational modification]; other site 198094003405 e3 binding domain; Region: E3_binding; pfam02817 198094003406 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198094003407 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 198094003408 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 198094003409 TPP-binding site [chemical binding]; other site 198094003410 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 198094003411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094003412 salt bridge; other site 198094003413 non-specific DNA binding site [nucleotide binding]; other site 198094003414 sequence-specific DNA binding site [nucleotide binding]; other site 198094003415 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 198094003416 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 198094003417 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 198094003418 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 198094003419 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 198094003420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094003421 S-adenosylmethionine binding site [chemical binding]; other site 198094003422 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198094003423 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094003424 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 198094003425 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198094003426 Catalytic site [active] 198094003427 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 198094003428 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 198094003429 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094003430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094003431 non-specific DNA binding site [nucleotide binding]; other site 198094003432 salt bridge; other site 198094003433 sequence-specific DNA binding site [nucleotide binding]; other site 198094003434 Anti-repressor SinI; Region: SinI; pfam08671 198094003435 Anti-repressor SinI; Region: SinI; pfam08671 198094003436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 198094003437 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 198094003438 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 198094003439 NAD(P) binding site [chemical binding]; other site 198094003440 catalytic residues [active] 198094003441 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 198094003442 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 198094003443 Walker A/P-loop; other site 198094003444 ATP binding site [chemical binding]; other site 198094003445 Q-loop/lid; other site 198094003446 ABC transporter signature motif; other site 198094003447 Walker B; other site 198094003448 D-loop; other site 198094003449 H-loop/switch region; other site 198094003450 TOBE domain; Region: TOBE_2; pfam08402 198094003451 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 198094003452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094003453 dimer interface [polypeptide binding]; other site 198094003454 conserved gate region; other site 198094003455 putative PBP binding loops; other site 198094003456 ABC-ATPase subunit interface; other site 198094003457 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198094003458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094003459 dimer interface [polypeptide binding]; other site 198094003460 conserved gate region; other site 198094003461 putative PBP binding loops; other site 198094003462 ABC-ATPase subunit interface; other site 198094003463 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 198094003464 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 198094003465 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198094003466 active site 198094003467 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 198094003468 MMPL family; Region: MMPL; cl14618 198094003469 MMPL family; Region: MMPL; cl14618 198094003470 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 198094003471 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198094003472 active site 198094003473 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 198094003474 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 198094003475 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 198094003476 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198094003477 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198094003478 Cysteine-rich domain; Region: CCG; pfam02754 198094003479 Cysteine-rich domain; Region: CCG; pfam02754 198094003480 FAD binding domain; Region: FAD_binding_4; pfam01565 198094003481 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 198094003482 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 198094003483 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 198094003484 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 198094003485 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 198094003486 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 198094003487 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 198094003488 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 198094003489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094003490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094003491 active site 198094003492 phosphorylation site [posttranslational modification] 198094003493 intermolecular recognition site; other site 198094003494 dimerization interface [polypeptide binding]; other site 198094003495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094003496 DNA binding site [nucleotide binding] 198094003497 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198094003498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094003499 dimerization interface [polypeptide binding]; other site 198094003500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094003501 dimer interface [polypeptide binding]; other site 198094003502 phosphorylation site [posttranslational modification] 198094003503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094003504 ATP binding site [chemical binding]; other site 198094003505 Mg2+ binding site [ion binding]; other site 198094003506 G-X-G motif; other site 198094003507 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198094003508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094003509 DNA-binding site [nucleotide binding]; DNA binding site 198094003510 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198094003511 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 198094003512 Cysteine-rich domain; Region: CCG; pfam02754 198094003513 Cysteine-rich domain; Region: CCG; pfam02754 198094003514 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 198094003515 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 198094003516 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198094003517 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 198094003518 Uncharacterized conserved protein [Function unknown]; Region: COG1556 198094003519 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 198094003520 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 198094003521 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 198094003522 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 198094003523 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 198094003524 Cation transport protein; Region: TrkH; cl17365 198094003525 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 198094003526 Cation transport protein; Region: TrkH; cl17365 198094003527 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 198094003528 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 198094003529 dimer interaction site [polypeptide binding]; other site 198094003530 substrate-binding tunnel; other site 198094003531 active site 198094003532 catalytic site [active] 198094003533 substrate binding site [chemical binding]; other site 198094003534 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 198094003535 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 198094003536 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094003537 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 198094003538 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 198094003539 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 198094003540 NAD(P) binding site [chemical binding]; other site 198094003541 active site 198094003542 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 198094003543 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 198094003544 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 198094003545 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 198094003546 FAD dependent oxidoreductase; Region: DAO; pfam01266 198094003547 Cation transport protein; Region: TrkH; cl17365 198094003548 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 198094003549 Cation transport protein; Region: TrkH; pfam02386 198094003550 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 198094003551 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 198094003552 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 198094003553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094003554 dimer interface [polypeptide binding]; other site 198094003555 conserved gate region; other site 198094003556 putative PBP binding loops; other site 198094003557 ABC-ATPase subunit interface; other site 198094003558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094003559 dimer interface [polypeptide binding]; other site 198094003560 conserved gate region; other site 198094003561 putative PBP binding loops; other site 198094003562 ABC-ATPase subunit interface; other site 198094003563 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 198094003564 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 198094003565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094003566 motif II; other site 198094003567 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 198094003568 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094003569 catalytic residue [active] 198094003570 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 198094003571 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198094003572 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 198094003573 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198094003574 FOG: CBS domain [General function prediction only]; Region: COG0517 198094003575 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 198094003576 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 198094003577 NodB motif; other site 198094003578 putative active site [active] 198094003579 putative catalytic site [active] 198094003580 Zn binding site [ion binding]; other site 198094003581 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 198094003582 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 198094003583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094003584 dimer interface [polypeptide binding]; other site 198094003585 phosphorylation site [posttranslational modification] 198094003586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094003587 ATP binding site [chemical binding]; other site 198094003588 Mg2+ binding site [ion binding]; other site 198094003589 G-X-G motif; other site 198094003590 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094003591 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094003592 dimerization interface [polypeptide binding]; other site 198094003593 putative DNA binding site [nucleotide binding]; other site 198094003594 putative Zn2+ binding site [ion binding]; other site 198094003595 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 198094003596 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 198094003597 active site 198094003598 Zn binding site [ion binding]; other site 198094003599 DinB superfamily; Region: DinB_2; pfam12867 198094003600 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198094003601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094003602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094003603 dimer interface [polypeptide binding]; other site 198094003604 phosphorylation site [posttranslational modification] 198094003605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094003606 ATP binding site [chemical binding]; other site 198094003607 Mg2+ binding site [ion binding]; other site 198094003608 G-X-G motif; other site 198094003609 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 198094003610 Ligand Binding Site [chemical binding]; other site 198094003611 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 198094003612 active site 198094003613 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 198094003614 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 198094003615 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 198094003616 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 198094003617 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 198094003618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094003619 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198094003620 Coenzyme A binding pocket [chemical binding]; other site 198094003621 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 198094003622 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 198094003623 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 198094003624 Class I ribonucleotide reductase; Region: RNR_I; cd01679 198094003625 active site 198094003626 dimer interface [polypeptide binding]; other site 198094003627 catalytic residues [active] 198094003628 effector binding site; other site 198094003629 R2 peptide binding site; other site 198094003630 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 198094003631 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 198094003632 GIY-YIG motif/motif A; other site 198094003633 putative active site [active] 198094003634 catalytic site [active] 198094003635 putative metal binding site [ion binding]; other site 198094003636 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cd00283 198094003637 DNA binding site [nucleotide binding] 198094003638 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 198094003639 dimer interface [polypeptide binding]; other site 198094003640 putative radical transfer pathway; other site 198094003641 diiron center [ion binding]; other site 198094003642 tyrosyl radical; other site 198094003643 Predicted transcriptional regulators [Transcription]; Region: COG1725 198094003644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094003645 DNA-binding site [nucleotide binding]; DNA binding site 198094003646 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198094003647 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094003648 Walker A/P-loop; other site 198094003649 ATP binding site [chemical binding]; other site 198094003650 Q-loop/lid; other site 198094003651 ABC transporter signature motif; other site 198094003652 Walker B; other site 198094003653 D-loop; other site 198094003654 H-loop/switch region; other site 198094003655 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094003656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094003657 Walker A/P-loop; other site 198094003658 ATP binding site [chemical binding]; other site 198094003659 Q-loop/lid; other site 198094003660 ABC transporter signature motif; other site 198094003661 Walker B; other site 198094003662 D-loop; other site 198094003663 H-loop/switch region; other site 198094003664 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 198094003665 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 198094003666 CAAX protease self-immunity; Region: Abi; pfam02517 198094003667 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 198094003668 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 198094003669 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198094003670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094003671 putative DNA binding site [nucleotide binding]; other site 198094003672 putative Zn2+ binding site [ion binding]; other site 198094003673 AsnC family; Region: AsnC_trans_reg; pfam01037 198094003674 Uncharacterized conserved protein [Function unknown]; Region: COG2128 198094003675 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 198094003676 catalytic triad [active] 198094003677 conserved cis-peptide bond; other site 198094003678 SseB protein N-terminal domain; Region: SseB; pfam07179 198094003679 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 198094003680 dimer interface [polypeptide binding]; other site 198094003681 catalytic triad [active] 198094003682 Nitronate monooxygenase; Region: NMO; pfam03060 198094003683 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 198094003684 FMN binding site [chemical binding]; other site 198094003685 substrate binding site [chemical binding]; other site 198094003686 putative catalytic residue [active] 198094003687 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 198094003688 DltD N-terminal region; Region: DltD_N; pfam04915 198094003689 DltD central region; Region: DltD_M; pfam04918 198094003690 DltD C-terminal region; Region: DltD_C; pfam04914 198094003691 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 198094003692 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 198094003693 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 198094003694 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 198094003695 acyl-activating enzyme (AAE) consensus motif; other site 198094003696 AMP binding site [chemical binding]; other site 198094003697 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 198094003698 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198094003699 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 198094003700 metal binding site [ion binding]; metal-binding site 198094003701 dimer interface [polypeptide binding]; other site 198094003702 flavodoxin; Provisional; Region: PRK06756 198094003703 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 198094003704 Phosphotransferase enzyme family; Region: APH; pfam01636 198094003705 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094003706 active site 198094003707 substrate binding site [chemical binding]; other site 198094003708 ATP binding site [chemical binding]; other site 198094003709 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 198094003710 multidrug efflux protein; Reviewed; Region: PRK01766 198094003711 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 198094003712 cation binding site [ion binding]; other site 198094003713 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 198094003714 Thioredoxin; Region: Thioredoxin_9; pfam14595 198094003715 Regulatory protein YrvL; Region: YrvL; pfam14184 198094003716 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094003717 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094003718 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 198094003719 Cation transport protein; Region: TrkH; cl17365 198094003720 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 198094003721 Cation transport protein; Region: TrkH; pfam02386 198094003722 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 198094003723 hypothetical protein; Provisional; Region: PRK03094 198094003724 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 198094003725 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 198094003726 homodimer interface [polypeptide binding]; other site 198094003727 substrate-cofactor binding pocket; other site 198094003728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094003729 catalytic residue [active] 198094003730 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 198094003731 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198094003732 PYR/PP interface [polypeptide binding]; other site 198094003733 dimer interface [polypeptide binding]; other site 198094003734 TPP binding site [chemical binding]; other site 198094003735 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198094003736 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198094003737 TPP-binding site [chemical binding]; other site 198094003738 dimer interface [polypeptide binding]; other site 198094003739 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 198094003740 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 198094003741 putative valine binding site [chemical binding]; other site 198094003742 dimer interface [polypeptide binding]; other site 198094003743 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 198094003744 ketol-acid reductoisomerase; Provisional; Region: PRK05479 198094003745 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 198094003746 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 198094003747 2-isopropylmalate synthase; Validated; Region: PRK00915 198094003748 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 198094003749 active site 198094003750 catalytic residues [active] 198094003751 metal binding site [ion binding]; metal-binding site 198094003752 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 198094003753 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 198094003754 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 198094003755 substrate binding site [chemical binding]; other site 198094003756 ligand binding site [chemical binding]; other site 198094003757 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 198094003758 substrate binding site [chemical binding]; other site 198094003759 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 198094003760 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 198094003761 dimer interface [polypeptide binding]; other site 198094003762 motif 1; other site 198094003763 active site 198094003764 motif 2; other site 198094003765 motif 3; other site 198094003766 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 198094003767 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 198094003768 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 198094003769 histidinol dehydrogenase; Region: hisD; TIGR00069 198094003770 NAD binding site [chemical binding]; other site 198094003771 dimerization interface [polypeptide binding]; other site 198094003772 product binding site; other site 198094003773 substrate binding site [chemical binding]; other site 198094003774 zinc binding site [ion binding]; other site 198094003775 catalytic residues [active] 198094003776 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 198094003777 putative active site pocket [active] 198094003778 4-fold oligomerization interface [polypeptide binding]; other site 198094003779 metal binding residues [ion binding]; metal-binding site 198094003780 3-fold/trimer interface [polypeptide binding]; other site 198094003781 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 198094003782 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 198094003783 putative active site [active] 198094003784 oxyanion strand; other site 198094003785 catalytic triad [active] 198094003786 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 198094003787 catalytic residues [active] 198094003788 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 198094003789 substrate binding site [chemical binding]; other site 198094003790 glutamase interaction surface [polypeptide binding]; other site 198094003791 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 198094003792 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 198094003793 metal binding site [ion binding]; metal-binding site 198094003794 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 198094003795 dimer interface [polypeptide binding]; other site 198094003796 active site 198094003797 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 198094003798 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 198094003799 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 198094003800 putative ligand binding site [chemical binding]; other site 198094003801 putative NAD binding site [chemical binding]; other site 198094003802 catalytic site [active] 198094003803 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 198094003804 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 198094003805 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 198094003806 Sulfatase; Region: Sulfatase; pfam00884 198094003807 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 198094003808 diaminopimelate decarboxylase; Region: lysA; TIGR01048 198094003809 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 198094003810 active site 198094003811 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198094003812 substrate binding site [chemical binding]; other site 198094003813 catalytic residues [active] 198094003814 dimer interface [polypeptide binding]; other site 198094003815 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 198094003816 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 198094003817 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 198094003818 Active Sites [active] 198094003819 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 198094003820 ATP-sulfurylase; Region: ATPS; cd00517 198094003821 active site 198094003822 HXXH motif; other site 198094003823 flexible loop; other site 198094003824 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 198094003825 ligand-binding site [chemical binding]; other site 198094003826 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 198094003827 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198094003828 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 198094003829 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198094003830 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198094003831 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 198094003832 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 198094003833 active site 198094003834 SAM binding site [chemical binding]; other site 198094003835 homodimer interface [polypeptide binding]; other site 198094003836 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 198094003837 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 198094003838 putative active site [active] 198094003839 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 198094003840 putative active site [active] 198094003841 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 198094003842 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 198094003843 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 198094003844 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 198094003845 Na2 binding site [ion binding]; other site 198094003846 putative substrate binding site 1 [chemical binding]; other site 198094003847 Na binding site 1 [ion binding]; other site 198094003848 putative substrate binding site 2 [chemical binding]; other site 198094003849 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 198094003850 Protein of unknown function (DUF342); Region: DUF342; cl19219 198094003851 Peptidase family M23; Region: Peptidase_M23; pfam01551 198094003852 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 198094003853 Protein of unknown function (DUF402); Region: DUF402; cl00979 198094003854 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 198094003855 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 198094003856 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 198094003857 Uncharacterized conserved protein [Function unknown]; Region: COG2966 198094003858 PspA/IM30 family; Region: PspA_IM30; pfam04012 198094003859 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094003860 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 198094003861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 198094003862 Histidine kinase; Region: HisKA_3; pfam07730 198094003863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094003864 ATP binding site [chemical binding]; other site 198094003865 Mg2+ binding site [ion binding]; other site 198094003866 G-X-G motif; other site 198094003867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198094003868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094003869 active site 198094003870 phosphorylation site [posttranslational modification] 198094003871 intermolecular recognition site; other site 198094003872 dimerization interface [polypeptide binding]; other site 198094003873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198094003874 DNA binding residues [nucleotide binding] 198094003875 dimerization interface [polypeptide binding]; other site 198094003876 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 198094003877 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 198094003878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094003879 S-adenosylmethionine binding site [chemical binding]; other site 198094003880 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 198094003881 Peptidase family M50; Region: Peptidase_M50; pfam02163 198094003882 active site 198094003883 putative substrate binding region [chemical binding]; other site 198094003884 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 198094003885 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 198094003886 heme-binding site [chemical binding]; other site 198094003887 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 198094003888 FAD binding pocket [chemical binding]; other site 198094003889 FAD binding motif [chemical binding]; other site 198094003890 phosphate binding motif [ion binding]; other site 198094003891 beta-alpha-beta structure motif; other site 198094003892 NAD binding pocket [chemical binding]; other site 198094003893 Heme binding pocket [chemical binding]; other site 198094003894 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 198094003895 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198094003896 ligand binding site [chemical binding]; other site 198094003897 flexible hinge region; other site 198094003898 non-specific DNA interactions [nucleotide binding]; other site 198094003899 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 198094003900 DNA binding site [nucleotide binding] 198094003901 sequence specific DNA binding site [nucleotide binding]; other site 198094003902 putative cAMP binding site [chemical binding]; other site 198094003903 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198094003904 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198094003905 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 198094003906 TIGR00153 family protein; Region: TIGR00153 198094003907 Transglycosylase; Region: Transgly; pfam00912 198094003908 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 198094003909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094003910 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 198094003911 Protein of unknown function DUF72; Region: DUF72; pfam01904 198094003912 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 198094003913 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198094003914 active site 198094003915 DNA binding site [nucleotide binding] 198094003916 Int/Topo IB signature motif; other site 198094003917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 198094003918 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094003919 dimerization interface [polypeptide binding]; other site 198094003920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094003921 dimer interface [polypeptide binding]; other site 198094003922 phosphorylation site [posttranslational modification] 198094003923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094003924 ATP binding site [chemical binding]; other site 198094003925 Mg2+ binding site [ion binding]; other site 198094003926 G-X-G motif; other site 198094003927 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 198094003928 Probable transposase; Region: OrfB_IS605; pfam01385 198094003929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 198094003930 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 198094003931 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 198094003932 Predicted integral membrane protein [Function unknown]; Region: COG0392 198094003933 Uncharacterized conserved protein [Function unknown]; Region: COG2898 198094003934 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 198094003935 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 198094003936 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 198094003937 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 198094003938 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 198094003939 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198094003940 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094003941 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 198094003942 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 198094003943 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 198094003944 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 198094003945 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094003946 RNA binding surface [nucleotide binding]; other site 198094003947 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 198094003948 active site 198094003949 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 198094003950 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 198094003951 catalytic residues [active] 198094003952 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 198094003953 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 198094003954 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094003955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094003956 active site 198094003957 phosphorylation site [posttranslational modification] 198094003958 intermolecular recognition site; other site 198094003959 dimerization interface [polypeptide binding]; other site 198094003960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094003961 DNA binding site [nucleotide binding] 198094003962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 198094003963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094003964 dimerization interface [polypeptide binding]; other site 198094003965 PAS domain; Region: PAS; smart00091 198094003966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094003967 dimer interface [polypeptide binding]; other site 198094003968 phosphorylation site [posttranslational modification] 198094003969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094003970 ATP binding site [chemical binding]; other site 198094003971 Mg2+ binding site [ion binding]; other site 198094003972 G-X-G motif; other site 198094003973 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 198094003974 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 198094003975 Peptidase family M23; Region: Peptidase_M23; pfam01551 198094003976 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 198094003977 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198094003978 Predicted membrane protein [Function unknown]; Region: COG3601 198094003979 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 198094003980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 198094003981 Helix-turn-helix domain; Region: HTH_40; pfam14493 198094003982 DEAD-like helicases superfamily; Region: DEXDc; smart00487 198094003983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094003984 ATP binding site [chemical binding]; other site 198094003985 putative Mg++ binding site [ion binding]; other site 198094003986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094003987 nucleotide binding region [chemical binding]; other site 198094003988 ATP-binding site [chemical binding]; other site 198094003989 CAAX protease self-immunity; Region: Abi; pfam02517 198094003990 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198094003991 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094003992 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 198094003993 DNA binding residues [nucleotide binding] 198094003994 B12 binding domain; Region: B12-binding_2; pfam02607 198094003995 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 198094003996 adaptor protein; Provisional; Region: PRK02899 198094003997 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 198094003998 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 198094003999 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 198094004000 NAD(P) binding site [chemical binding]; other site 198094004001 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 198094004002 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198094004003 amidase catalytic site [active] 198094004004 Zn binding residues [ion binding]; other site 198094004005 substrate binding site [chemical binding]; other site 198094004006 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 198094004007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 198094004008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094004009 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 198094004010 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 198094004011 active site 198094004012 homotetramer interface [polypeptide binding]; other site 198094004013 homodimer interface [polypeptide binding]; other site 198094004014 cytidylate kinase; Provisional; Region: cmk; PRK00023 198094004015 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 198094004016 AAA domain; Region: AAA_18; pfam13238 198094004017 CMP-binding site; other site 198094004018 The sites determining sugar specificity; other site 198094004019 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 198094004020 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 198094004021 RNA binding site [nucleotide binding]; other site 198094004022 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 198094004023 RNA binding site [nucleotide binding]; other site 198094004024 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 198094004025 RNA binding site [nucleotide binding]; other site 198094004026 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 198094004027 RNA binding site [nucleotide binding]; other site 198094004028 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 198094004029 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 198094004030 homotetramer interface [polypeptide binding]; other site 198094004031 FMN binding site [chemical binding]; other site 198094004032 homodimer contacts [polypeptide binding]; other site 198094004033 putative active site [active] 198094004034 putative substrate binding site [chemical binding]; other site 198094004035 YpzI-like protein; Region: YpzI; pfam14140 198094004036 YIEGIA protein; Region: YIEGIA; pfam14045 198094004037 GTP-binding protein Der; Reviewed; Region: PRK00093 198094004038 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 198094004039 G1 box; other site 198094004040 GTP/Mg2+ binding site [chemical binding]; other site 198094004041 Switch I region; other site 198094004042 G2 box; other site 198094004043 Switch II region; other site 198094004044 G3 box; other site 198094004045 G4 box; other site 198094004046 G5 box; other site 198094004047 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 198094004048 G1 box; other site 198094004049 GTP/Mg2+ binding site [chemical binding]; other site 198094004050 Switch I region; other site 198094004051 G2 box; other site 198094004052 G3 box; other site 198094004053 Switch II region; other site 198094004054 G4 box; other site 198094004055 G5 box; other site 198094004056 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 198094004057 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 198094004058 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 198094004059 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 198094004060 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 198094004061 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 198094004062 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 198094004063 histone-like DNA-binding protein HU; Region: HU; cd13831 198094004064 dimer interface [polypeptide binding]; other site 198094004065 DNA binding site [nucleotide binding] 198094004066 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 198094004067 homodecamer interface [polypeptide binding]; other site 198094004068 active site 198094004069 putative catalytic site residues [active] 198094004070 zinc binding site [ion binding]; other site 198094004071 GTP-CH-I/GFRP interaction surface; other site 198094004072 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 198094004073 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 198094004074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094004075 S-adenosylmethionine binding site [chemical binding]; other site 198094004076 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 198094004077 substrate binding pocket [chemical binding]; other site 198094004078 chain length determination region; other site 198094004079 substrate-Mg2+ binding site; other site 198094004080 catalytic residues [active] 198094004081 aspartate-rich region 1; other site 198094004082 active site lid residues [active] 198094004083 aspartate-rich region 2; other site 198094004084 Nucleoside diphosphate kinase; Region: NDK; pfam00334 198094004085 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 198094004086 active site 198094004087 multimer interface [polypeptide binding]; other site 198094004088 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 198094004089 Tetramer interface [polypeptide binding]; other site 198094004090 active site 198094004091 FMN-binding site [chemical binding]; other site 198094004092 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 198094004093 active site 198094004094 dimer interface [polypeptide binding]; other site 198094004095 metal binding site [ion binding]; metal-binding site 198094004096 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 198094004097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094004098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094004099 homodimer interface [polypeptide binding]; other site 198094004100 catalytic residue [active] 198094004101 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 198094004102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094004103 binding surface 198094004104 TPR motif; other site 198094004105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094004106 binding surface 198094004107 TPR motif; other site 198094004108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094004109 binding surface 198094004110 TPR motif; other site 198094004111 hypothetical protein; Provisional; Region: PRK03636 198094004112 UPF0302 domain; Region: UPF0302; pfam08864 198094004113 IDEAL domain; Region: IDEAL; pfam08858 198094004114 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 198094004115 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 198094004116 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 198094004117 iron-sulfur cluster [ion binding]; other site 198094004118 [2Fe-2S] cluster binding site [ion binding]; other site 198094004119 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 198094004120 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 198094004121 interchain domain interface [polypeptide binding]; other site 198094004122 intrachain domain interface; other site 198094004123 heme bH binding site [chemical binding]; other site 198094004124 Qi binding site; other site 198094004125 heme bL binding site [chemical binding]; other site 198094004126 Qo binding site; other site 198094004127 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 198094004128 interchain domain interface [polypeptide binding]; other site 198094004129 intrachain domain interface; other site 198094004130 Qi binding site; other site 198094004131 Qo binding site; other site 198094004132 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 198094004133 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 198094004134 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 198094004135 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 198094004136 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 198094004137 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 198094004138 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 198094004139 active site 198094004140 Fe-S cluster binding site [ion binding]; other site 198094004141 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094004142 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094004143 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094004144 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094004145 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 198094004146 homodimer interface [polypeptide binding]; other site 198094004147 metal binding site [ion binding]; metal-binding site 198094004148 dihydrodipicolinate reductase; Provisional; Region: PRK00048 198094004149 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 198094004150 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 198094004151 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 198094004152 active site 198094004153 dimer interfaces [polypeptide binding]; other site 198094004154 catalytic residues [active] 198094004155 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 198094004156 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 198094004157 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 198094004158 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 198094004159 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 198094004160 active site 198094004161 NTP binding site [chemical binding]; other site 198094004162 metal binding triad [ion binding]; metal-binding site 198094004163 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 198094004164 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 198094004165 Biotin operon repressor [Transcription]; Region: BirA; COG1654 198094004166 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 198094004167 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 198094004168 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 198094004169 Uncharacterized subfamiy of Cupredoxin; Region: Cupredoxin_like_3; cd04203 198094004170 Type 1 (T1) Cu binding site [ion binding]; other site 198094004171 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 198094004172 oligomerization interface [polypeptide binding]; other site 198094004173 active site 198094004174 metal binding site [ion binding]; metal-binding site 198094004175 Pantoate-beta-alanine ligase; Region: PanC; cd00560 198094004176 active site 198094004177 ATP-binding site [chemical binding]; other site 198094004178 pantoate-binding site; other site 198094004179 HXXH motif; other site 198094004180 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 198094004181 tetramerization interface [polypeptide binding]; other site 198094004182 active site 198094004183 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 198094004184 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 198094004185 active site 198094004186 catalytic site [active] 198094004187 substrate binding site [chemical binding]; other site 198094004188 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 198094004189 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 198094004190 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 198094004191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 198094004192 aspartate aminotransferase; Provisional; Region: PRK05764 198094004193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094004194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094004195 homodimer interface [polypeptide binding]; other site 198094004196 catalytic residue [active] 198094004197 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 198094004198 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 198094004199 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 198094004200 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 198094004201 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198094004202 minor groove reading motif; other site 198094004203 helix-hairpin-helix signature motif; other site 198094004204 substrate binding pocket [chemical binding]; other site 198094004205 active site 198094004206 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 198094004207 Transglycosylase; Region: Transgly; pfam00912 198094004208 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 198094004209 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094004210 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198094004211 Interdomain contacts; other site 198094004212 Cytokine receptor motif; other site 198094004213 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 198094004214 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 198094004215 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 198094004216 YppF-like protein; Region: YppF; pfam14178 198094004217 YppG-like protein; Region: YppG; pfam14179 198094004218 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 198094004219 hypothetical protein; Provisional; Region: PRK13660 198094004220 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 198094004221 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 198094004222 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 198094004223 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 198094004224 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 198094004225 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 198094004226 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 198094004227 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 198094004228 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 198094004229 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 198094004230 active site 198094004231 Zn binding site [ion binding]; other site 198094004232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094004233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094004234 Coenzyme A binding pocket [chemical binding]; other site 198094004235 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 198094004236 Phosphotransferase enzyme family; Region: APH; pfam01636 198094004237 putative active site [active] 198094004238 putative substrate binding site [chemical binding]; other site 198094004239 ATP binding site [chemical binding]; other site 198094004240 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 198094004241 active site 198094004242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094004243 active site 198094004244 Sulfate transporter family; Region: Sulfate_transp; cl19250 198094004245 xanthine permease; Region: pbuX; TIGR03173 198094004246 Predicted membrane protein [Function unknown]; Region: COG2311 198094004247 Protein of unknown function (DUF418); Region: DUF418; pfam04235 198094004248 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 198094004249 G1 box; other site 198094004250 GTP/Mg2+ binding site [chemical binding]; other site 198094004251 G2 box; other site 198094004252 Switch I region; other site 198094004253 G3 box; other site 198094004254 Switch II region; other site 198094004255 G4 box; other site 198094004256 G5 box; other site 198094004257 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 198094004258 G1 box; other site 198094004259 GTP/Mg2+ binding site [chemical binding]; other site 198094004260 G2 box; other site 198094004261 Switch I region; other site 198094004262 G3 box; other site 198094004263 Switch II region; other site 198094004264 G4 box; other site 198094004265 G5 box; other site 198094004266 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 198094004267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094004268 Coenzyme A binding pocket [chemical binding]; other site 198094004269 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 198094004270 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 198094004271 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 198094004272 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 198094004273 active site residue [active] 198094004274 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 198094004275 active site residue [active] 198094004276 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 198094004277 Predicted membrane protein [Function unknown]; Region: COG3766 198094004278 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 198094004279 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 198094004280 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 198094004281 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198094004282 5'-3' exonuclease; Region: 53EXOc; smart00475 198094004283 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 198094004284 active site 198094004285 metal binding site 1 [ion binding]; metal-binding site 198094004286 putative 5' ssDNA interaction site; other site 198094004287 metal binding site 3; metal-binding site 198094004288 metal binding site 2 [ion binding]; metal-binding site 198094004289 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 198094004290 putative DNA binding site [nucleotide binding]; other site 198094004291 putative metal binding site [ion binding]; other site 198094004292 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 198094004293 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 198094004294 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 198094004295 Chain length determinant protein; Region: Wzz; pfam02706 198094004296 Bacterial sugar transferase; Region: Bac_transf; pfam02397 198094004297 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198094004298 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 198094004299 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 198094004300 O-Antigen ligase; Region: Wzy_C; pfam04932 198094004301 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198094004302 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 198094004303 active site 198094004304 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 198094004305 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004306 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004307 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004308 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004309 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004310 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004311 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004312 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004313 Domain of unknown function DUF11; Region: DUF11; cl17728 198094004314 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004315 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004316 Domain of unknown function DUF11; Region: DUF11; cl17728 198094004317 Domain of unknown function DUF11; Region: DUF11; cl17728 198094004318 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004319 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004320 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004321 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004322 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004323 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004324 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004325 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004326 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004327 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004328 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004329 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004330 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004331 Domain of unknown function DUF11; Region: DUF11; cl17728 198094004332 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004333 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004334 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004335 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094004336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094004337 Coenzyme A binding pocket [chemical binding]; other site 198094004338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094004339 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 198094004340 catalytic triad [active] 198094004341 conserved cis-peptide bond; other site 198094004342 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094004343 EamA-like transporter family; Region: EamA; pfam00892 198094004344 EamA-like transporter family; Region: EamA; pfam00892 198094004345 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 198094004346 RNA/DNA hybrid binding site [nucleotide binding]; other site 198094004347 active site 198094004348 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 198094004349 active site 198094004350 catalytic residues [active] 198094004351 QueT transporter; Region: QueT; pfam06177 198094004352 hypothetical protein; Validated; Region: PRK07708 198094004353 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 198094004354 RNA/DNA hybrid binding site [nucleotide binding]; other site 198094004355 active site 198094004356 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 198094004357 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 198094004358 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198094004359 DNA-binding site [nucleotide binding]; DNA binding site 198094004360 RNA-binding motif; other site 198094004361 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 198094004362 LysE type translocator; Region: LysE; cl00565 198094004363 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 198094004364 Protein of unknown function, DUF485; Region: DUF485; pfam04341 198094004365 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 198094004366 Na binding site [ion binding]; other site 198094004367 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198094004368 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094004369 inhibitor-cofactor binding pocket; inhibition site 198094004370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094004371 catalytic residue [active] 198094004372 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 198094004373 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 198094004374 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 198094004375 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094004376 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 198094004377 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094004378 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 198094004379 DNA binding residues [nucleotide binding] 198094004380 drug binding residues [chemical binding]; other site 198094004381 dimer interface [polypeptide binding]; other site 198094004382 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 198094004383 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 198094004384 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 198094004385 Predicted membrane protein [Function unknown]; Region: COG2323 198094004386 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198094004387 putative active site [active] 198094004388 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 198094004389 dimer interface [polypeptide binding]; other site 198094004390 FMN binding site [chemical binding]; other site 198094004391 NADPH bind site [chemical binding]; other site 198094004392 DJ-1 family protein; Region: not_thiJ; TIGR01383 198094004393 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 198094004394 conserved cys residue [active] 198094004395 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198094004396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094004397 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094004398 putative substrate translocation pore; other site 198094004399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094004400 dimerization interface [polypeptide binding]; other site 198094004401 putative DNA binding site [nucleotide binding]; other site 198094004402 putative Zn2+ binding site [ion binding]; other site 198094004403 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094004404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094004405 putative substrate translocation pore; other site 198094004406 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 198094004407 active site 198094004408 metal binding site [ion binding]; metal-binding site 198094004409 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 198094004410 bacterial Hfq-like; Region: Hfq; cd01716 198094004411 hexamer interface [polypeptide binding]; other site 198094004412 Sm1 motif; other site 198094004413 RNA binding site [nucleotide binding]; other site 198094004414 Sm2 motif; other site 198094004415 HD domain; Region: HD_3; pfam13023 198094004416 flagellar motor protein MotP; Reviewed; Region: PRK06743 198094004417 flagellar motor protein MotS; Reviewed; Region: PRK06742 198094004418 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198094004419 ligand binding site [chemical binding]; other site 198094004420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094004421 active site 198094004422 phosphorylation site [posttranslational modification] 198094004423 intermolecular recognition site; other site 198094004424 dimerization interface [polypeptide binding]; other site 198094004425 flagellar motor switch protein; Reviewed; Region: PRK06782 198094004426 CheC-like family; Region: CheC; pfam04509 198094004427 CheC-like family; Region: CheC; pfam04509 198094004428 CheC-like family; Region: CheC; pfam04509 198094004429 CheC-like family; Region: CheC; pfam04509 198094004430 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 198094004431 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 198094004432 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 198094004433 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 198094004434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094004435 Protein of unknown function (DUF327); Region: DUF327; pfam03885 198094004436 Glutamate-cysteine ligase; Region: GshA; cl19621 198094004437 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 198094004438 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198094004439 flagellar capping protein; Validated; Region: fliD; PRK06798 198094004440 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 198094004441 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 198094004442 Flagellar protein FliS; Region: FliS; cl00654 198094004443 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 198094004444 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 198094004445 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 198094004446 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198094004447 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 198094004448 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 198094004449 FliG N-terminal domain; Region: FliG_N; pfam14842 198094004450 FliG middle domain; Region: FliG_M; pfam14841 198094004451 FliG C-terminal domain; Region: FliG_C; pfam01706 198094004452 flagellar assembly protein H; Validated; Region: fliH; PRK06800 198094004453 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 198094004454 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198094004455 Walker A motif; other site 198094004456 ATP binding site [chemical binding]; other site 198094004457 Walker B motif; other site 198094004458 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 198094004459 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 198094004460 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 198094004461 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198094004462 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 198094004463 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 198094004464 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198094004465 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 198094004466 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 198094004467 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198094004468 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094004469 active site 198094004470 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 198094004471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198094004472 TPR repeat; Region: TPR_11; pfam13414 198094004473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094004474 binding surface 198094004475 TPR motif; other site 198094004476 flagellin; Provisional; Region: PRK12807 198094004477 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 198094004478 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 198094004479 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 198094004480 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198094004481 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198094004482 catalytic residue [active] 198094004483 flagellar motor switch protein; Validated; Region: PRK06788 198094004484 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 198094004485 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 198094004486 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 198094004487 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 198094004488 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 198094004489 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 198094004490 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 198094004491 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198094004492 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 198094004493 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 198094004494 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 198094004495 Predicted transcriptional regulators [Transcription]; Region: COG1378 198094004496 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 198094004497 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 198094004498 C-terminal domain interface [polypeptide binding]; other site 198094004499 sugar binding site [chemical binding]; other site 198094004500 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 198094004501 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 198094004502 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 198094004503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094004504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094004505 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 198094004506 Dienelactone hydrolase family; Region: DLH; pfam01738 198094004507 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 198094004508 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 198094004509 transcriptional repressor DicA; Reviewed; Region: PRK09706 198094004510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094004511 non-specific DNA binding site [nucleotide binding]; other site 198094004512 salt bridge; other site 198094004513 sequence-specific DNA binding site [nucleotide binding]; other site 198094004514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094004515 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094004516 putative substrate translocation pore; other site 198094004517 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 198094004518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094004519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094004520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198094004521 dimerization interface [polypeptide binding]; other site 198094004522 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 198094004523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094004524 Walker A/P-loop; other site 198094004525 ATP binding site [chemical binding]; other site 198094004526 Q-loop/lid; other site 198094004527 ABC transporter signature motif; other site 198094004528 Walker B; other site 198094004529 D-loop; other site 198094004530 H-loop/switch region; other site 198094004531 TOBE domain; Region: TOBE_2; pfam08402 198094004532 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 198094004533 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 198094004534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094004535 dimer interface [polypeptide binding]; other site 198094004536 conserved gate region; other site 198094004537 putative PBP binding loops; other site 198094004538 ABC-ATPase subunit interface; other site 198094004539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094004540 dimer interface [polypeptide binding]; other site 198094004541 conserved gate region; other site 198094004542 putative PBP binding loops; other site 198094004543 ABC-ATPase subunit interface; other site 198094004544 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 198094004545 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 198094004546 Beta-Casp domain; Region: Beta-Casp; pfam10996 198094004547 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 198094004548 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 198094004549 Cupin; Region: Cupin_1; smart00835 198094004550 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094004551 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 198094004552 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198094004553 catalytic core [active] 198094004554 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094004555 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094004556 hypothetical protein; Provisional; Region: PRK09272 198094004557 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 198094004558 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 198094004559 active site 198094004560 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 198094004561 dimer interface [polypeptide binding]; other site 198094004562 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 198094004563 Ligand Binding Site [chemical binding]; other site 198094004564 Molecular Tunnel; other site 198094004565 RNA polymerase factor sigma-70; Validated; Region: PRK06811 198094004566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094004567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094004568 DNA binding residues [nucleotide binding] 198094004569 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 198094004570 VPS10 domain; Region: VPS10; smart00602 198094004571 VPS10 domain; Region: VPS10; smart00602 198094004572 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 198094004573 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 198094004574 Transcriptional regulators [Transcription]; Region: GntR; COG1802 198094004575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094004576 DNA-binding site [nucleotide binding]; DNA binding site 198094004577 FCD domain; Region: FCD; pfam07729 198094004578 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094004579 EamA-like transporter family; Region: EamA; pfam00892 198094004580 EamA-like transporter family; Region: EamA; pfam00892 198094004581 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 198094004582 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 198094004583 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 198094004584 Predicted permeases [General function prediction only]; Region: COG0701 198094004585 TIGR03943 family protein; Region: TIGR03943 198094004586 Methyltransferase domain; Region: Methyltransf_24; pfam13578 198094004587 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 198094004588 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 198094004589 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 198094004590 fumarate hydratase; Reviewed; Region: fumC; PRK00485 198094004591 Class II fumarases; Region: Fumarase_classII; cd01362 198094004592 active site 198094004593 tetramer interface [polypeptide binding]; other site 198094004594 Bacterial PH domain; Region: bPH_4; pfam06713 198094004595 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 198094004596 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 198094004597 active site pocket [active] 198094004598 oxyanion hole [active] 198094004599 catalytic triad [active] 198094004600 active site nucleophile [active] 198094004601 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 198094004602 Penicillinase repressor; Region: Penicillinase_R; pfam03965 198094004603 Peptidase family M48; Region: Peptidase_M48; cl12018 198094004604 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 198094004605 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 198094004606 catalytic residues [active] 198094004607 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 198094004608 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 198094004609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094004610 non-specific DNA binding site [nucleotide binding]; other site 198094004611 salt bridge; other site 198094004612 sequence-specific DNA binding site [nucleotide binding]; other site 198094004613 Cupin domain; Region: Cupin_2; pfam07883 198094004614 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 198094004615 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094004616 catalytic residue [active] 198094004617 Protein of unknown function (DUF445); Region: DUF445; pfam04286 198094004618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 198094004619 Uncharacterized protein KIAA1328; Region: KIAA1328; pfam15369 198094004620 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 198094004621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094004622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094004623 DNA binding residues [nucleotide binding] 198094004624 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198094004625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094004626 active site 198094004627 phosphorylation site [posttranslational modification] 198094004628 intermolecular recognition site; other site 198094004629 dimerization interface [polypeptide binding]; other site 198094004630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198094004631 DNA binding residues [nucleotide binding] 198094004632 dimerization interface [polypeptide binding]; other site 198094004633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 198094004634 Histidine kinase; Region: HisKA_3; pfam07730 198094004635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094004636 Mg2+ binding site [ion binding]; other site 198094004637 G-X-G motif; other site 198094004638 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094004639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094004640 Walker A/P-loop; other site 198094004641 ATP binding site [chemical binding]; other site 198094004642 Q-loop/lid; other site 198094004643 ABC transporter signature motif; other site 198094004644 Walker B; other site 198094004645 D-loop; other site 198094004646 H-loop/switch region; other site 198094004647 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 198094004648 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 198094004649 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198094004650 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 198094004651 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 198094004652 PLD-like domain; Region: PLDc_2; pfam13091 198094004653 putative active site [active] 198094004654 catalytic site [active] 198094004655 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 198094004656 PLD-like domain; Region: PLDc_2; pfam13091 198094004657 putative active site [active] 198094004658 catalytic site [active] 198094004659 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 198094004660 putative nucleotide binding site [chemical binding]; other site 198094004661 uridine monophosphate binding site [chemical binding]; other site 198094004662 homohexameric interface [polypeptide binding]; other site 198094004663 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 198094004664 aspartate ammonia-lyase; Provisional; Region: PRK14515 198094004665 Aspartase; Region: Aspartase; cd01357 198094004666 active sites [active] 198094004667 tetramer interface [polypeptide binding]; other site 198094004668 malate dehydrogenase; Provisional; Region: PRK13529 198094004669 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198094004670 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 198094004671 NAD(P) binding site [chemical binding]; other site 198094004672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094004673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094004674 ATP binding site [chemical binding]; other site 198094004675 Mg2+ binding site [ion binding]; other site 198094004676 G-X-G motif; other site 198094004677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094004678 active site 198094004679 phosphorylation site [posttranslational modification] 198094004680 intermolecular recognition site; other site 198094004681 dimerization interface [polypeptide binding]; other site 198094004682 YcbB domain; Region: YcbB; pfam08664 198094004683 SWIM zinc finger; Region: SWIM; pfam04434 198094004684 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 198094004685 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 198094004686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094004687 ATP binding site [chemical binding]; other site 198094004688 putative Mg++ binding site [ion binding]; other site 198094004689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094004690 nucleotide binding region [chemical binding]; other site 198094004691 ATP-binding site [chemical binding]; other site 198094004692 Protein of unknown function (DUF3934); Region: DUF3934; pfam13070 198094004693 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 198094004694 dimer interface [polypeptide binding]; other site 198094004695 active site 198094004696 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 198094004697 putative dimer interface [polypeptide binding]; other site 198094004698 aspartate kinase; Reviewed; Region: PRK06635 198094004699 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 198094004700 putative nucleotide binding site [chemical binding]; other site 198094004701 putative catalytic residues [active] 198094004702 putative Mg ion binding site [ion binding]; other site 198094004703 putative aspartate binding site [chemical binding]; other site 198094004704 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 198094004705 putative allosteric regulatory site; other site 198094004706 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 198094004707 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 198094004708 YndJ-like protein; Region: YndJ; pfam14158 198094004709 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 198094004710 putative active site [active] 198094004711 nucleotide binding site [chemical binding]; other site 198094004712 nudix motif; other site 198094004713 putative metal binding site [ion binding]; other site 198094004714 S-layer homology domain; Region: SLH; pfam00395 198094004715 S-layer homology domain; Region: SLH; pfam00395 198094004716 S-layer homology domain; Region: SLH; pfam00395 198094004717 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 198094004718 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198094004719 active site 198094004720 metal binding site [ion binding]; metal-binding site 198094004721 S-layer homology domain; Region: SLH; pfam00395 198094004722 S-layer homology domain; Region: SLH; pfam00395 198094004723 S-layer homology domain; Region: SLH; pfam00395 198094004724 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 198094004725 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094004726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094004727 putative substrate translocation pore; other site 198094004728 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 198094004729 Carbon starvation protein CstA; Region: CstA; pfam02554 198094004730 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 198094004731 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 198094004732 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 198094004733 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 198094004734 dimer interface [polypeptide binding]; other site 198094004735 active site 198094004736 CoA binding pocket [chemical binding]; other site 198094004737 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 198094004738 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 198094004739 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 198094004740 HflX GTPase family; Region: HflX; cd01878 198094004741 G1 box; other site 198094004742 GTP/Mg2+ binding site [chemical binding]; other site 198094004743 Switch I region; other site 198094004744 G2 box; other site 198094004745 G3 box; other site 198094004746 Switch II region; other site 198094004747 G4 box; other site 198094004748 G5 box; other site 198094004749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094004750 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094004751 putative substrate translocation pore; other site 198094004752 cysteine synthase; Region: PLN02565 198094004753 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198094004754 dimer interface [polypeptide binding]; other site 198094004755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094004756 catalytic residue [active] 198094004757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094004758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094004759 Coenzyme A binding pocket [chemical binding]; other site 198094004760 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 198094004761 stage V sporulation protein B; Region: spore_V_B; TIGR02900 198094004762 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 198094004763 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 198094004764 Na2 binding site [ion binding]; other site 198094004765 putative substrate binding site 1 [chemical binding]; other site 198094004766 Na binding site 1 [ion binding]; other site 198094004767 putative substrate binding site 2 [chemical binding]; other site 198094004768 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 198094004769 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 198094004770 NodB motif; other site 198094004771 putative active site [active] 198094004772 putative catalytic site [active] 198094004773 putative Zn binding site [ion binding]; other site 198094004774 Mor transcription activator family; Region: Mor; cl02360 198094004775 Predicted membrane protein [Function unknown]; Region: COG2323 198094004776 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 198094004777 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 198094004778 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 198094004779 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 198094004780 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 198094004781 methionine sulfoxide reductase A; Provisional; Region: PRK14054 198094004782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 198094004783 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 198094004784 NADP binding site [chemical binding]; other site 198094004785 homodimer interface [polypeptide binding]; other site 198094004786 active site 198094004787 substrate binding site [chemical binding]; other site 198094004788 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 198094004789 homodimer interface [polypeptide binding]; other site 198094004790 substrate-cofactor binding pocket; other site 198094004791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094004792 catalytic residue [active] 198094004793 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 198094004794 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198094004795 PYR/PP interface [polypeptide binding]; other site 198094004796 dimer interface [polypeptide binding]; other site 198094004797 TPP binding site [chemical binding]; other site 198094004798 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198094004799 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198094004800 TPP-binding site [chemical binding]; other site 198094004801 dimer interface [polypeptide binding]; other site 198094004802 acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737 198094004803 ketol-acid reductoisomerase; Provisional; Region: PRK05479 198094004804 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 198094004805 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 198094004806 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 198094004807 threonine dehydratase; Validated; Region: PRK08639 198094004808 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 198094004809 tetramer interface [polypeptide binding]; other site 198094004810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094004811 catalytic residue [active] 198094004812 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 198094004813 putative Ile/Val binding site [chemical binding]; other site 198094004814 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 198094004815 putative active site [active] 198094004816 putative metal binding site [ion binding]; other site 198094004817 Protein of unknown function (DUF554); Region: DUF554; pfam04474 198094004818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094004819 Coenzyme A binding pocket [chemical binding]; other site 198094004820 drug efflux system protein MdtG; Provisional; Region: PRK09874 198094004821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094004822 putative substrate translocation pore; other site 198094004823 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 198094004824 putative active site [active] 198094004825 metal binding site [ion binding]; metal-binding site 198094004826 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 198094004827 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198094004828 LytTr DNA-binding domain; Region: LytTR; pfam04397 198094004829 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 198094004830 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 198094004831 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 198094004832 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 198094004833 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094004834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094004835 Coenzyme A binding pocket [chemical binding]; other site 198094004836 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 198094004837 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 198094004838 active site 198094004839 putative substrate binding pocket [chemical binding]; other site 198094004840 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094004841 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 198094004842 hypothetical protein; Provisional; Region: PRK06922 198094004843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094004844 S-adenosylmethionine binding site [chemical binding]; other site 198094004845 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 198094004846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094004847 FeS/SAM binding site; other site 198094004848 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 198094004849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094004850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094004851 Coenzyme A binding pocket [chemical binding]; other site 198094004852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094004853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094004854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094004855 active site 198094004856 phosphorylation site [posttranslational modification] 198094004857 intermolecular recognition site; other site 198094004858 dimerization interface [polypeptide binding]; other site 198094004859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094004860 DNA binding site [nucleotide binding] 198094004861 Peptidase family M23; Region: Peptidase_M23; pfam01551 198094004862 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 198094004863 manganese transport protein MntH; Reviewed; Region: PRK00701 198094004864 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 198094004865 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 198094004866 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 198094004867 active site residue [active] 198094004868 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 198094004869 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 198094004870 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 198094004871 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 198094004872 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 198094004873 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 198094004874 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 198094004875 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198094004876 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 198094004877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 198094004878 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 198094004879 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 198094004880 intersubunit interface [polypeptide binding]; other site 198094004881 active site 198094004882 catalytic residue [active] 198094004883 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198094004884 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198094004885 Nucleoside recognition; Region: Gate; pfam07670 198094004886 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198094004887 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 198094004888 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198094004889 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198094004890 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 198094004891 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 198094004892 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198094004893 active site 198094004894 catalytic motif [active] 198094004895 Zn binding site [ion binding]; other site 198094004896 hypothetical protein; Provisional; Region: PRK01631 198094004897 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 198094004898 VPS10 domain; Region: VPS10; smart00602 198094004899 proline aminopeptidase P II; Provisional; Region: PRK10879 198094004900 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 198094004901 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 198094004902 active site 198094004903 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 198094004904 The first cupredoxin domain of bacteria two domain multicopper oxidase; Region: CuRO_1_2dMco_1; cd13860 198094004905 putative trimer interface [polypeptide binding]; other site 198094004906 trinuclear Cu binding site [ion binding]; other site 198094004907 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 198094004908 trimer interface [polypeptide binding]; other site 198094004909 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 198094004910 trimer interface [polypeptide binding]; other site 198094004911 trinuclear Cu binding site [ion binding]; other site 198094004912 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094004913 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094004914 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094004915 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094004916 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 198094004917 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094004918 Peptidase family M23; Region: Peptidase_M23; pfam01551 198094004919 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 198094004920 DNA topoisomerase III; Provisional; Region: PRK07726 198094004921 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 198094004922 active site 198094004923 putative interdomain interaction site [polypeptide binding]; other site 198094004924 putative metal-binding site [ion binding]; other site 198094004925 putative nucleotide binding site [chemical binding]; other site 198094004926 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198094004927 domain I; other site 198094004928 DNA binding groove [nucleotide binding] 198094004929 phosphate binding site [ion binding]; other site 198094004930 domain II; other site 198094004931 domain III; other site 198094004932 nucleotide binding site [chemical binding]; other site 198094004933 catalytic site [active] 198094004934 domain IV; other site 198094004935 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198094004936 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 198094004937 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 198094004938 azoreductase; Provisional; Region: PRK13555 198094004939 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 198094004940 dimer interface [polypeptide binding]; other site 198094004941 substrate binding site [chemical binding]; other site 198094004942 metal binding site [ion binding]; metal-binding site 198094004943 CopC domain; Region: CopC; pfam04234 198094004944 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 198094004945 YtkA-like; Region: YtkA; pfam13115 198094004946 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 198094004947 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094004948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094004949 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094004950 EamA-like transporter family; Region: EamA; pfam00892 198094004951 EamA-like transporter family; Region: EamA; pfam00892 198094004952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094004953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094004954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198094004955 dimerization interface [polypeptide binding]; other site 198094004956 Rrf2 family protein; Region: rrf2_super; TIGR00738 198094004957 Transcriptional regulator; Region: Rrf2; pfam02082 198094004958 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 198094004959 catalytic residues [active] 198094004960 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 198094004961 dimer interface [polypeptide binding]; other site 198094004962 FMN binding site [chemical binding]; other site 198094004963 amidase; Provisional; Region: PRK06707 198094004964 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 198094004965 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 198094004966 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 198094004967 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198094004968 NAD binding site [chemical binding]; other site 198094004969 dimer interface [polypeptide binding]; other site 198094004970 substrate binding site [chemical binding]; other site 198094004971 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 198094004972 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198094004973 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 198094004974 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 198094004975 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 198094004976 S-layer homology domain; Region: SLH; pfam00395 198094004977 S-layer homology domain; Region: SLH; pfam00395 198094004978 S-layer homology domain; Region: SLH; pfam00395 198094004979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094004980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094004981 acyl-CoA synthetase; Validated; Region: PRK06839 198094004982 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 198094004983 acyl-activating enzyme (AAE) consensus motif; other site 198094004984 putative AMP binding site [chemical binding]; other site 198094004985 putative active site [active] 198094004986 putative CoA binding site [chemical binding]; other site 198094004987 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 198094004988 dimer interaction site [polypeptide binding]; other site 198094004989 substrate-binding tunnel; other site 198094004990 active site 198094004991 catalytic site [active] 198094004992 substrate binding site [chemical binding]; other site 198094004993 hypothetical protein; Validated; Region: PRK06840 198094004994 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 198094004995 active site 198094004996 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 198094004997 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 198094004998 putative ligand binding site [chemical binding]; other site 198094004999 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 198094005000 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 198094005001 Walker A/P-loop; other site 198094005002 ATP binding site [chemical binding]; other site 198094005003 Q-loop/lid; other site 198094005004 ABC transporter signature motif; other site 198094005005 Walker B; other site 198094005006 D-loop; other site 198094005007 H-loop/switch region; other site 198094005008 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 198094005009 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 198094005010 Walker A/P-loop; other site 198094005011 ATP binding site [chemical binding]; other site 198094005012 Q-loop/lid; other site 198094005013 ABC transporter signature motif; other site 198094005014 Walker B; other site 198094005015 D-loop; other site 198094005016 H-loop/switch region; other site 198094005017 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 198094005018 TM-ABC transporter signature motif; other site 198094005019 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 198094005020 TM-ABC transporter signature motif; other site 198094005021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094005022 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 198094005023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198094005024 dimerization interface [polypeptide binding]; other site 198094005025 Tautomerase enzyme; Region: Tautomerase_2; pfam14552 198094005026 active site 1 [active] 198094005027 dimer interface [polypeptide binding]; other site 198094005028 hexamer interface [polypeptide binding]; other site 198094005029 active site 2 [active] 198094005030 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 198094005031 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094005032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094005033 putative Zn2+ binding site [ion binding]; other site 198094005034 putative DNA binding site [nucleotide binding]; other site 198094005035 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 198094005036 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 198094005037 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 198094005038 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 198094005039 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 198094005040 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 198094005041 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094005042 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 198094005043 Walker A/P-loop; other site 198094005044 ATP binding site [chemical binding]; other site 198094005045 Q-loop/lid; other site 198094005046 ABC transporter signature motif; other site 198094005047 Walker B; other site 198094005048 D-loop; other site 198094005049 H-loop/switch region; other site 198094005050 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 198094005051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094005052 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 198094005053 Walker A/P-loop; other site 198094005054 ATP binding site [chemical binding]; other site 198094005055 Q-loop/lid; other site 198094005056 ABC transporter signature motif; other site 198094005057 Walker B; other site 198094005058 D-loop; other site 198094005059 H-loop/switch region; other site 198094005060 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 198094005061 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 198094005062 putative dimer interface [polypeptide binding]; other site 198094005063 catalytic triad [active] 198094005064 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198094005065 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094005066 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 198094005067 dimer interface [polypeptide binding]; other site 198094005068 FMN binding site [chemical binding]; other site 198094005069 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094005070 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094005071 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094005072 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198094005073 NlpC/P60 family; Region: NLPC_P60; pfam00877 198094005074 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094005075 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094005076 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094005077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094005078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094005079 active site 198094005080 phosphorylation site [posttranslational modification] 198094005081 intermolecular recognition site; other site 198094005082 dimerization interface [polypeptide binding]; other site 198094005083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094005084 DNA binding site [nucleotide binding] 198094005085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094005086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094005087 dimerization interface [polypeptide binding]; other site 198094005088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094005089 dimer interface [polypeptide binding]; other site 198094005090 phosphorylation site [posttranslational modification] 198094005091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094005092 ATP binding site [chemical binding]; other site 198094005093 Mg2+ binding site [ion binding]; other site 198094005094 G-X-G motif; other site 198094005095 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 198094005096 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 198094005097 classical (c) SDRs; Region: SDR_c; cd05233 198094005098 NAD(P) binding site [chemical binding]; other site 198094005099 active site 198094005100 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 198094005101 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 198094005102 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 198094005103 NodB motif; other site 198094005104 active site 198094005105 catalytic site [active] 198094005106 metal binding site [ion binding]; metal-binding site 198094005107 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 198094005108 nudix motif; other site 198094005109 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 198094005110 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 198094005111 homoserine dehydrogenase; Provisional; Region: PRK06349 198094005112 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198094005113 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198094005114 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 198094005115 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 198094005116 cysteine synthase; Region: PLN02565 198094005117 homodimer interface [polypeptide binding]; other site 198094005118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094005119 catalytic residue [active] 198094005120 homoserine kinase; Provisional; Region: PRK01212 198094005121 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198094005122 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 198094005123 Protein of unknown function (DUF1183); Region: DUF1183; pfam06682 198094005124 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 198094005125 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 198094005126 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094005127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094005128 active site 198094005129 phosphorylation site [posttranslational modification] 198094005130 intermolecular recognition site; other site 198094005131 dimerization interface [polypeptide binding]; other site 198094005132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094005133 DNA binding site [nucleotide binding] 198094005134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094005135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094005136 dimerization interface [polypeptide binding]; other site 198094005137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094005138 dimer interface [polypeptide binding]; other site 198094005139 phosphorylation site [posttranslational modification] 198094005140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094005141 ATP binding site [chemical binding]; other site 198094005142 Mg2+ binding site [ion binding]; other site 198094005143 G-X-G motif; other site 198094005144 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 198094005145 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 198094005146 NodB motif; other site 198094005147 active site 198094005148 catalytic site [active] 198094005149 Zn binding site [ion binding]; other site 198094005150 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 198094005151 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 198094005152 MgtC family; Region: MgtC; pfam02308 198094005153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094005154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005155 Coenzyme A binding pocket [chemical binding]; other site 198094005156 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 198094005157 IucA / IucC family; Region: IucA_IucC; pfam04183 198094005158 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198094005159 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 198094005160 IucA / IucC family; Region: IucA_IucC; pfam04183 198094005161 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198094005162 acyl-CoA synthetase; Validated; Region: PRK08308 198094005163 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198094005164 acyl-activating enzyme (AAE) consensus motif; other site 198094005165 AMP binding site [chemical binding]; other site 198094005166 active site 198094005167 CoA binding site [chemical binding]; other site 198094005168 acyl carrier protein; Provisional; Region: PRK07639 198094005169 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 198094005170 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198094005171 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 198094005172 Lysine efflux permease [General function prediction only]; Region: COG1279 198094005173 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 198094005174 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 198094005175 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 198094005176 active site 198094005177 nucleophile elbow; other site 198094005178 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 198094005179 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 198094005180 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 198094005181 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 198094005182 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 198094005183 nudix motif; other site 198094005184 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 198094005185 homodimer interface [polypeptide binding]; other site 198094005186 NAD binding pocket [chemical binding]; other site 198094005187 ATP binding pocket [chemical binding]; other site 198094005188 Mg binding site [ion binding]; other site 198094005189 active-site loop [active] 198094005190 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 198094005191 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 198094005192 Subtilase family; Region: Peptidase_S8; pfam00082 198094005193 active site 198094005194 catalytic residues [active] 198094005195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094005196 dimerization interface [polypeptide binding]; other site 198094005197 putative DNA binding site [nucleotide binding]; other site 198094005198 putative Zn2+ binding site [ion binding]; other site 198094005199 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 198094005200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094005201 active site 198094005202 catalytic tetrad [active] 198094005203 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198094005204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094005205 putative substrate translocation pore; other site 198094005206 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 198094005207 DinB superfamily; Region: DinB_2; pfam12867 198094005208 GTPase RsgA; Reviewed; Region: PRK01889 198094005209 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 198094005210 RNA binding site [nucleotide binding]; other site 198094005211 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 198094005212 GTPase/Zn-binding domain interface [polypeptide binding]; other site 198094005213 GTP/Mg2+ binding site [chemical binding]; other site 198094005214 G4 box; other site 198094005215 G5 box; other site 198094005216 G1 box; other site 198094005217 Switch I region; other site 198094005218 G2 box; other site 198094005219 G3 box; other site 198094005220 Switch II region; other site 198094005221 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198094005222 Cache domain; Region: Cache_1; pfam02743 198094005223 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198094005224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094005225 dimerization interface [polypeptide binding]; other site 198094005226 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198094005227 dimer interface [polypeptide binding]; other site 198094005228 putative CheW interface [polypeptide binding]; other site 198094005229 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 198094005230 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 198094005231 Ferritin-like domain; Region: Ferritin; pfam00210 198094005232 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 198094005233 dimerization interface [polypeptide binding]; other site 198094005234 DPS ferroxidase diiron center [ion binding]; other site 198094005235 ion pore; other site 198094005236 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 198094005237 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 198094005238 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 198094005239 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 198094005240 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 198094005241 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 198094005242 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 198094005243 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 198094005244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198094005245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094005246 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094005247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094005248 active site 198094005249 catalytic tetrad [active] 198094005250 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 198094005251 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 198094005252 P-loop, Walker A motif; other site 198094005253 Base recognition motif; other site 198094005254 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 198094005255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094005256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005257 Coenzyme A binding pocket [chemical binding]; other site 198094005258 exosporium leader peptide; Region: exospor_lead; TIGR03720 198094005259 Predicted membrane protein [Function unknown]; Region: COG4640 198094005260 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 198094005261 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 198094005262 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 198094005263 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 198094005264 metal binding site [ion binding]; metal-binding site 198094005265 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 198094005266 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 198094005267 NAD binding site [chemical binding]; other site 198094005268 active site 198094005269 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 198094005270 active site 198094005271 FMN binding site [chemical binding]; other site 198094005272 substrate binding site [chemical binding]; other site 198094005273 homotetramer interface [polypeptide binding]; other site 198094005274 catalytic residue [active] 198094005275 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 198094005276 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 198094005277 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198094005278 DNA binding site [nucleotide binding] 198094005279 active site 198094005280 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 198094005281 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094005282 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094005283 peptide binding site [polypeptide binding]; other site 198094005284 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 198094005285 active site 198094005286 metal binding site [ion binding]; metal-binding site 198094005287 short chain dehydrogenase; Provisional; Region: PRK08309 198094005288 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198094005289 catalytic core [active] 198094005290 CotH protein; Region: CotH; cl19892 198094005291 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 198094005292 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 198094005293 nudix motif; other site 198094005294 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198094005295 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198094005296 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 198094005297 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 198094005298 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 198094005299 Cl binding site [ion binding]; other site 198094005300 oligomer interface [polypeptide binding]; other site 198094005301 Predicted permeases [General function prediction only]; Region: COG0701 198094005302 Predicted membrane protein [Function unknown]; Region: COG3689 198094005303 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 198094005304 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 198094005305 PLD-like domain; Region: PLDc_2; pfam13091 198094005306 putative active site [active] 198094005307 catalytic site [active] 198094005308 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 198094005309 PLD-like domain; Region: PLDc_2; pfam13091 198094005310 putative active site [active] 198094005311 catalytic site [active] 198094005312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094005313 NAD(P) binding site [chemical binding]; other site 198094005314 active site 198094005315 Protein of unknown function (DUF456); Region: DUF456; pfam04306 198094005316 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 198094005317 Domain of unknown function DUF21; Region: DUF21; pfam01595 198094005318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198094005319 Transporter associated domain; Region: CorC_HlyC; smart01091 198094005320 FOG: CBS domain [General function prediction only]; Region: COG0517 198094005321 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 198094005322 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 198094005323 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 198094005324 dimer interface [polypeptide binding]; other site 198094005325 putative tRNA-binding site [nucleotide binding]; other site 198094005326 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 198094005327 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 198094005328 stage II sporulation protein P; Region: spore_II_P; TIGR02867 198094005329 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094005330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005331 Coenzyme A binding pocket [chemical binding]; other site 198094005332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094005333 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 198094005334 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 198094005335 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 198094005336 nudix motif; other site 198094005337 amidase; Provisional; Region: PRK06828 198094005338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094005339 putative substrate translocation pore; other site 198094005340 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094005341 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 198094005342 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 198094005343 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 198094005344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198094005345 catalytic core [active] 198094005346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094005347 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 198094005348 active site 198094005349 motif I; other site 198094005350 motif II; other site 198094005351 DinB superfamily; Region: DinB_2; pfam12867 198094005352 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 198094005353 alanine racemase; Reviewed; Region: alr; PRK00053 198094005354 active site 198094005355 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198094005356 dimer interface [polypeptide binding]; other site 198094005357 substrate binding site [chemical binding]; other site 198094005358 catalytic residues [active] 198094005359 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 198094005360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094005361 S-adenosylmethionine binding site [chemical binding]; other site 198094005362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005363 Coenzyme A binding pocket [chemical binding]; other site 198094005364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005365 Coenzyme A binding pocket [chemical binding]; other site 198094005366 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094005367 active site 198094005368 ATP binding site [chemical binding]; other site 198094005369 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 198094005370 glycosyltransferase, MGT family; Region: MGT; TIGR01426 198094005371 active site 198094005372 TDP-binding site; other site 198094005373 acceptor substrate-binding pocket; other site 198094005374 homodimer interface [polypeptide binding]; other site 198094005375 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094005376 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094005377 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094005378 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198094005379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094005380 DNA-binding site [nucleotide binding]; DNA binding site 198094005381 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094005382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094005383 homodimer interface [polypeptide binding]; other site 198094005384 catalytic residue [active] 198094005385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094005386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005387 Coenzyme A binding pocket [chemical binding]; other site 198094005388 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 198094005389 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094005390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005391 Coenzyme A binding pocket [chemical binding]; other site 198094005392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094005393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094005394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005395 Coenzyme A binding pocket [chemical binding]; other site 198094005396 Cupin domain; Region: Cupin_2; cl17218 198094005397 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 198094005398 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 198094005399 Winged helix DNA-binding domain; Region: HTH_42; cl19833 198094005400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094005401 S-adenosylmethionine binding site [chemical binding]; other site 198094005402 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 198094005403 Potassium binding sites [ion binding]; other site 198094005404 Cesium cation binding sites [ion binding]; other site 198094005405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 198094005406 DEAD-like helicases superfamily; Region: DEXDc; smart00487 198094005407 ATP binding site [chemical binding]; other site 198094005408 putative Mg++ binding site [ion binding]; other site 198094005409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094005410 nucleotide binding region [chemical binding]; other site 198094005411 ATP-binding site [chemical binding]; other site 198094005412 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 198094005413 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198094005414 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 198094005415 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198094005416 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 198094005417 NADP binding site [chemical binding]; other site 198094005418 dimer interface [polypeptide binding]; other site 198094005419 RNA polymerase sigma factor; Provisional; Region: PRK12543 198094005420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094005421 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094005422 DNA binding residues [nucleotide binding] 198094005423 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 198094005424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094005425 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 198094005426 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 198094005427 catalytic residues [active] 198094005428 dimer interface [polypeptide binding]; other site 198094005429 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 198094005430 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 198094005431 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 198094005432 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 198094005433 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 198094005434 Protein of unknown function DUF58; Region: DUF58; pfam01882 198094005435 MoxR-like ATPases [General function prediction only]; Region: COG0714 198094005436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094005437 Walker A motif; other site 198094005438 ATP binding site [chemical binding]; other site 198094005439 Walker B motif; other site 198094005440 arginine finger; other site 198094005441 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 198094005442 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 198094005443 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 198094005444 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 198094005445 [4Fe-4S] binding site [ion binding]; other site 198094005446 molybdopterin cofactor binding site [chemical binding]; other site 198094005447 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 198094005448 molybdopterin cofactor binding site; other site 198094005449 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 198094005450 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198094005451 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 198094005452 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 198094005453 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 198094005454 Predicted transcriptional regulators [Transcription]; Region: COG1725 198094005455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094005456 DNA-binding site [nucleotide binding]; DNA binding site 198094005457 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094005458 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094005459 Walker A/P-loop; other site 198094005460 ATP binding site [chemical binding]; other site 198094005461 Q-loop/lid; other site 198094005462 ABC transporter signature motif; other site 198094005463 Walker B; other site 198094005464 D-loop; other site 198094005465 H-loop/switch region; other site 198094005466 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 198094005467 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198094005468 ligand binding site [chemical binding]; other site 198094005469 flexible hinge region; other site 198094005470 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 198094005471 putative switch regulator; other site 198094005472 non-specific DNA interactions [nucleotide binding]; other site 198094005473 DNA binding site [nucleotide binding] 198094005474 sequence specific DNA binding site [nucleotide binding]; other site 198094005475 putative cAMP binding site [chemical binding]; other site 198094005476 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 198094005477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094005478 FeS/SAM binding site; other site 198094005479 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 198094005480 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 198094005481 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198094005482 ATP binding site [chemical binding]; other site 198094005483 substrate interface [chemical binding]; other site 198094005484 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 198094005485 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 198094005486 dimer interface [polypeptide binding]; other site 198094005487 putative functional site; other site 198094005488 putative MPT binding site; other site 198094005489 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 198094005490 MoaE homodimer interface [polypeptide binding]; other site 198094005491 MoaD interaction [polypeptide binding]; other site 198094005492 active site residues [active] 198094005493 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 198094005494 MoaE interaction surface [polypeptide binding]; other site 198094005495 MoeB interaction surface [polypeptide binding]; other site 198094005496 thiocarboxylated glycine; other site 198094005497 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 198094005498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094005499 putative substrate translocation pore; other site 198094005500 Membrane transport protein; Region: Mem_trans; cl09117 198094005501 precorrin-2 dehydrogenase; Validated; Region: PRK06719 198094005502 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 198094005503 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 198094005504 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 198094005505 putative active site [active] 198094005506 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 198094005507 putative active site [active] 198094005508 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 198094005509 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 198094005510 active site 198094005511 SAM binding site [chemical binding]; other site 198094005512 homodimer interface [polypeptide binding]; other site 198094005513 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 198094005514 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 198094005515 [2Fe-2S] cluster binding site [ion binding]; other site 198094005516 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 198094005517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094005518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094005519 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198094005520 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198094005521 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198094005522 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 198094005523 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 198094005524 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 198094005525 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 198094005526 Fe binding site [ion binding]; other site 198094005527 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 198094005528 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 198094005529 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094005530 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 198094005531 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 198094005532 N-acetyltransferase; Region: Acetyltransf_2; cl00949 198094005533 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094005534 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094005535 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 198094005536 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 198094005537 DNA translocase FtsK; Provisional; Region: PRK10263 198094005538 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 198094005539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094005540 Zn2+ binding site [ion binding]; other site 198094005541 Mg2+ binding site [ion binding]; other site 198094005542 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 198094005543 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094005544 ABC transporter; Region: ABC_tran_2; pfam12848 198094005545 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094005546 Bax inhibitor 1 like; Region: BaxI_1; cl17691 198094005547 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 198094005548 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 198094005549 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 198094005550 dimer interface [polypeptide binding]; other site 198094005551 ssDNA binding site [nucleotide binding]; other site 198094005552 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198094005553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094005554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094005555 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 198094005556 Virulence factor; Region: Virulence_fact; pfam13769 198094005557 HEAT repeats; Region: HEAT_2; pfam13646 198094005558 HEAT repeats; Region: HEAT_2; pfam13646 198094005559 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 198094005560 Protein of unknown function, DUF393; Region: DUF393; pfam04134 198094005561 Disulphide isomerase; Region: Disulph_isomer; pfam06491 198094005562 Brix domain; Region: Brix; cl00935 198094005563 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 198094005564 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 198094005565 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 198094005566 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 198094005567 active site 198094005568 HIGH motif; other site 198094005569 KMSK motif region; other site 198094005570 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 198094005571 tRNA binding surface [nucleotide binding]; other site 198094005572 anticodon binding site; other site 198094005573 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 198094005574 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094005575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094005576 S-adenosylmethionine binding site [chemical binding]; other site 198094005577 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 198094005578 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 198094005579 active site 198094005580 HIGH motif; other site 198094005581 KMSKS motif; other site 198094005582 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 198094005583 tRNA binding surface [nucleotide binding]; other site 198094005584 anticodon binding site; other site 198094005585 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 198094005586 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 198094005587 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 198094005588 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 198094005589 Zn binding site [ion binding]; other site 198094005590 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 198094005591 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 198094005592 Dimer interface [polypeptide binding]; other site 198094005593 anticodon binding site; other site 198094005594 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 198094005595 homodimer interface [polypeptide binding]; other site 198094005596 motif 1; other site 198094005597 motif 2; other site 198094005598 active site 198094005599 motif 3; other site 198094005600 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 198094005601 metal ion-dependent adhesion site (MIDAS); other site 198094005602 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 198094005603 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 198094005604 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198094005605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094005606 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 198094005607 G1 box; other site 198094005608 Walker A motif; other site 198094005609 ATP binding site [chemical binding]; other site 198094005610 GTP/Mg2+ binding site [chemical binding]; other site 198094005611 Switch I region; other site 198094005612 G3 box; other site 198094005613 Switch II region; other site 198094005614 G4 box; other site 198094005615 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198094005616 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 198094005617 SseB protein N-terminal domain; Region: SseB; pfam07179 198094005618 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 198094005619 Pre-toxin TG; Region: PT-TG; pfam14449 198094005620 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 198094005621 Immunity protein Imm3; Region: Imm3; pfam14425 198094005622 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 198094005623 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 198094005624 catalytic residues [active] 198094005625 catalytic nucleophile [active] 198094005626 Recombinase; Region: Recombinase; pfam07508 198094005627 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 198094005628 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 198094005629 Glycerate kinase family; Region: Gly_kinase; cl00841 198094005630 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 198094005631 anion transporter; Region: dass; TIGR00785 198094005632 transmembrane helices; other site 198094005633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094005634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094005635 active site 198094005636 phosphorylation site [posttranslational modification] 198094005637 intermolecular recognition site; other site 198094005638 dimerization interface [polypeptide binding]; other site 198094005639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094005640 DNA binding site [nucleotide binding] 198094005641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094005642 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094005643 dimerization interface [polypeptide binding]; other site 198094005644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094005645 dimer interface [polypeptide binding]; other site 198094005646 phosphorylation site [posttranslational modification] 198094005647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094005648 ATP binding site [chemical binding]; other site 198094005649 Mg2+ binding site [ion binding]; other site 198094005650 G-X-G motif; other site 198094005651 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 198094005652 Predicted membrane protein [Function unknown]; Region: COG3212 198094005653 Predicted membrane protein [Function unknown]; Region: COG3212 198094005654 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 198094005655 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 198094005656 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 198094005657 Na2 binding site [ion binding]; other site 198094005658 putative substrate binding site 1 [chemical binding]; other site 198094005659 Na binding site 1 [ion binding]; other site 198094005660 putative substrate binding site 2 [chemical binding]; other site 198094005661 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094005662 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094005663 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 198094005664 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 198094005665 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 198094005666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094005667 active site 198094005668 motif I; other site 198094005669 motif II; other site 198094005670 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 198094005671 fructuronate transporter; Provisional; Region: PRK10034; cl15264 198094005672 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 198094005673 putative active site [active] 198094005674 metal binding site [ion binding]; metal-binding site 198094005675 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 198094005676 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 198094005677 homodimer interaction site [polypeptide binding]; other site 198094005678 cofactor binding site; other site 198094005679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005680 Coenzyme A binding pocket [chemical binding]; other site 198094005681 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198094005682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005683 Coenzyme A binding pocket [chemical binding]; other site 198094005684 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198094005685 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094005686 Walker A/P-loop; other site 198094005687 ATP binding site [chemical binding]; other site 198094005688 Q-loop/lid; other site 198094005689 ABC transporter signature motif; other site 198094005690 Walker B; other site 198094005691 D-loop; other site 198094005692 H-loop/switch region; other site 198094005693 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 198094005694 YpjP-like protein; Region: YpjP; pfam14005 198094005695 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 198094005696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094005697 active site 198094005698 motif I; other site 198094005699 motif II; other site 198094005700 hypothetical protein; Provisional; Region: PRK06724 198094005701 active site 198094005702 Phosphotransferase enzyme family; Region: APH; pfam01636 198094005703 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 198094005704 active site 198094005705 ATP binding site [chemical binding]; other site 198094005706 substrate binding site [chemical binding]; other site 198094005707 Peptidase family S41; Region: Peptidase_S41; pfam03572 198094005708 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094005709 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 198094005710 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 198094005711 dimerization interface [polypeptide binding]; other site 198094005712 active site 198094005713 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 198094005714 folate binding site [chemical binding]; other site 198094005715 NADP+ binding site [chemical binding]; other site 198094005716 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 198094005717 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198094005718 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 198094005719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094005720 azoreductase; Reviewed; Region: PRK00170 198094005721 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 198094005722 putative acyl-acceptor binding pocket; other site 198094005723 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 198094005724 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 198094005725 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 198094005726 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 198094005727 EDD domain protein, DegV family; Region: DegV; TIGR00762 198094005728 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 198094005729 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 198094005730 Cu(I) binding site [ion binding]; other site 198094005731 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198094005732 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 198094005733 putative dimer interface [polypeptide binding]; other site 198094005734 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 198094005735 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 198094005736 active site 198094005737 dimer interface [polypeptide binding]; other site 198094005738 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 198094005739 Ligand Binding Site [chemical binding]; other site 198094005740 Molecular Tunnel; other site 198094005741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094005742 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198094005743 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198094005744 siderophore binding site; other site 198094005745 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 198094005746 homodimer interface [polypeptide binding]; other site 198094005747 substrate-cofactor binding pocket; other site 198094005748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094005749 catalytic residue [active] 198094005750 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 198094005751 FMN binding site [chemical binding]; other site 198094005752 dimer interface [polypeptide binding]; other site 198094005753 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 198094005754 nudix motif; other site 198094005755 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198094005756 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 198094005757 putative dimer interface [polypeptide binding]; other site 198094005758 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 198094005759 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198094005760 GAF domain; Region: GAF_2; pfam13185 198094005761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 198094005762 Histidine kinase; Region: HisKA_3; pfam07730 198094005763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094005764 ATP binding site [chemical binding]; other site 198094005765 Mg2+ binding site [ion binding]; other site 198094005766 G-X-G motif; other site 198094005767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198094005768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094005769 active site 198094005770 phosphorylation site [posttranslational modification] 198094005771 intermolecular recognition site; other site 198094005772 dimerization interface [polypeptide binding]; other site 198094005773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198094005774 DNA binding residues [nucleotide binding] 198094005775 dimerization interface [polypeptide binding]; other site 198094005776 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 198094005777 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 198094005778 NAD binding site [chemical binding]; other site 198094005779 substrate binding site [chemical binding]; other site 198094005780 catalytic Zn binding site [ion binding]; other site 198094005781 tetramer interface [polypeptide binding]; other site 198094005782 structural Zn binding site [ion binding]; other site 198094005783 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094005784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094005785 dimer interface [polypeptide binding]; other site 198094005786 conserved gate region; other site 198094005787 ABC-ATPase subunit interface; other site 198094005788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 198094005789 Erythromycin esterase; Region: Erythro_esteras; cl17110 198094005790 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198094005791 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094005792 active site 198094005793 Predicted flavoprotein [General function prediction only]; Region: COG0431 198094005794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094005795 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094005796 putative substrate translocation pore; other site 198094005797 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198094005798 putative active site [active] 198094005799 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 198094005800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094005801 Walker A/P-loop; other site 198094005802 ATP binding site [chemical binding]; other site 198094005803 Q-loop/lid; other site 198094005804 ABC transporter signature motif; other site 198094005805 Walker B; other site 198094005806 D-loop; other site 198094005807 H-loop/switch region; other site 198094005808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094005809 dimer interface [polypeptide binding]; other site 198094005810 conserved gate region; other site 198094005811 putative PBP binding loops; other site 198094005812 ABC-ATPase subunit interface; other site 198094005813 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 198094005814 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 198094005815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 198094005816 Protein of unknown function (DUF524); Region: DUF524; pfam04411 198094005817 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 198094005818 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 198094005819 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 198094005820 Domain of unknown function DUF21; Region: DUF21; pfam01595 198094005821 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198094005822 Transporter associated domain; Region: CorC_HlyC; smart01091 198094005823 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 198094005824 NAD(P) binding site [chemical binding]; other site 198094005825 catalytic residues [active] 198094005826 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 198094005827 Histidine kinase N terminal; Region: HisK_N; pfam09385 198094005828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094005829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094005830 dimer interface [polypeptide binding]; other site 198094005831 phosphorylation site [posttranslational modification] 198094005832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094005833 ATP binding site [chemical binding]; other site 198094005834 Mg2+ binding site [ion binding]; other site 198094005835 G-X-G motif; other site 198094005836 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 198094005837 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 198094005838 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198094005839 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094005840 inhibitor-cofactor binding pocket; inhibition site 198094005841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094005842 catalytic residue [active] 198094005843 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 198094005844 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 198094005845 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 198094005846 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 198094005847 metal binding site [ion binding]; metal-binding site 198094005848 dimer interface [polypeptide binding]; other site 198094005849 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 198094005850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094005851 Coenzyme A binding pocket [chemical binding]; other site 198094005852 PAS fold; Region: PAS_4; pfam08448 198094005853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094005854 putative active site [active] 198094005855 heme pocket [chemical binding]; other site 198094005856 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 198094005857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094005858 Walker A motif; other site 198094005859 ATP binding site [chemical binding]; other site 198094005860 Walker B motif; other site 198094005861 arginine finger; other site 198094005862 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198094005863 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 198094005864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094005865 FeS/SAM binding site; other site 198094005866 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 198094005867 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 198094005868 toxin interface [polypeptide binding]; other site 198094005869 Zn binding site [ion binding]; other site 198094005870 hypothetical protein; Provisional; Region: PRK13672 198094005871 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 198094005872 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 198094005873 YozD-like protein; Region: YozD; pfam14162 198094005874 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 198094005875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 198094005876 active site 198094005877 ATP binding site [chemical binding]; other site 198094005878 substrate binding site [chemical binding]; other site 198094005879 activation loop (A-loop); other site 198094005880 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; cl19290 198094005881 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198094005882 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 198094005883 active site 198094005884 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 198094005885 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198094005886 catalytic residues [active] 198094005887 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198094005888 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 198094005889 DNA binding site [nucleotide binding] 198094005890 active site 198094005891 Int/Topo IB signature motif; other site 198094005892 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 198094005893 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 198094005894 S-layer homology domain; Region: SLH; pfam00395 198094005895 S-layer homology domain; Region: SLH; pfam00395 198094005896 S-layer homology domain; Region: SLH; pfam00395 198094005897 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 198094005898 PLD-like domain; Region: PLDc_2; pfam13091 198094005899 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 198094005900 putative active site [active] 198094005901 putative active site [active] 198094005902 catalytic site [active] 198094005903 catalytic site [active] 198094005904 Restriction endonuclease; Region: Mrr_cat; pfam04471 198094005905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094005906 non-specific DNA binding site [nucleotide binding]; other site 198094005907 salt bridge; other site 198094005908 sequence-specific DNA binding site [nucleotide binding]; other site 198094005909 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198094005910 Replication-relaxation; Region: Replic_Relax; pfam13814 198094005911 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198094005912 homotrimer interaction site [polypeptide binding]; other site 198094005913 putative active site [active] 198094005914 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 198094005915 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 198094005916 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 198094005917 C1q domain; Region: C1q; cl17543 198094005918 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 198094005919 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198094005920 YolD-like protein; Region: YolD; pfam08863 198094005921 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 198094005922 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 198094005923 KTSC domain; Region: KTSC; pfam13619 198094005924 Transglycosylase; Region: Transgly; pfam00912 198094005925 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 198094005926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094005927 Nucleoporin FG repeat region; Region: Nucleoporin_FG; pfam13634 198094005928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094005929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094005930 putative substrate translocation pore; other site 198094005931 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 198094005932 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 198094005933 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 198094005934 dimer interface [polypeptide binding]; other site 198094005935 active site 198094005936 coenzyme A binding site [chemical binding]; other site 198094005937 citrylCoA binding site [chemical binding]; other site 198094005938 oxalacetate/citrate binding site [chemical binding]; other site 198094005939 catalytic triad [active] 198094005940 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 198094005941 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 198094005942 tetramer interface [polypeptide binding]; other site 198094005943 active site 198094005944 Mg2+/Mn2+ binding site [ion binding]; other site 198094005945 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 198094005946 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 198094005947 active site 198094005948 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 198094005949 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 198094005950 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 198094005951 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 198094005952 tetrameric interface [polypeptide binding]; other site 198094005953 NAD binding site [chemical binding]; other site 198094005954 catalytic residues [active] 198094005955 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198094005956 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 198094005957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198094005958 substrate binding site [chemical binding]; other site 198094005959 oxyanion hole (OAH) forming residues; other site 198094005960 trimer interface [polypeptide binding]; other site 198094005961 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 198094005962 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 198094005963 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 198094005964 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 198094005965 active site 198094005966 metal binding site [ion binding]; metal-binding site 198094005967 DNA binding site [nucleotide binding] 198094005968 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 198094005969 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 198094005970 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 198094005971 Walker A/P-loop; other site 198094005972 ATP binding site [chemical binding]; other site 198094005973 Q-loop/lid; other site 198094005974 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 198094005975 ABC transporter signature motif; other site 198094005976 Walker B; other site 198094005977 D-loop; other site 198094005978 H-loop/switch region; other site 198094005979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094005980 dimerization interface [polypeptide binding]; other site 198094005981 putative DNA binding site [nucleotide binding]; other site 198094005982 putative Zn2+ binding site [ion binding]; other site 198094005983 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 198094005984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094005985 putative substrate translocation pore; other site 198094005986 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 198094005987 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 198094005988 NAD(P) binding site [chemical binding]; other site 198094005989 active site 198094005990 isochorismate synthase DhbC; Validated; Region: PRK06923 198094005991 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 198094005992 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 198094005993 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 198094005994 acyl-activating enzyme (AAE) consensus motif; other site 198094005995 active site 198094005996 AMP binding site [chemical binding]; other site 198094005997 substrate binding site [chemical binding]; other site 198094005998 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 198094005999 catalytic triad [active] 198094006000 conserved cis-peptide bond; other site 198094006001 Phosphopantetheine attachment site; Region: PP-binding; cl09936 198094006002 Condensation domain; Region: Condensation; cl19241 198094006003 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 198094006004 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 198094006005 acyl-activating enzyme (AAE) consensus motif; other site 198094006006 AMP binding site [chemical binding]; other site 198094006007 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198094006008 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 198094006009 Condensation domain; Region: Condensation; pfam00668 198094006010 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 198094006011 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 198094006012 acyl-activating enzyme (AAE) consensus motif; other site 198094006013 AMP binding site [chemical binding]; other site 198094006014 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198094006015 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 198094006016 MbtH-like protein; Region: MbtH; pfam03621 198094006017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006018 putative transporter; Provisional; Region: PRK10504 198094006019 putative substrate translocation pore; other site 198094006020 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 198094006021 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 198094006022 histone-like DNA-binding protein HU; Region: HU; cd13831 198094006023 dimer interface [polypeptide binding]; other site 198094006024 DNA binding site [nucleotide binding] 198094006025 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 198094006026 DinB family; Region: DinB; cl17821 198094006027 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 198094006028 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 198094006029 Subtilase family; Region: Peptidase_S8; pfam00082 198094006030 active site 198094006031 catalytic triad [active] 198094006032 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 198094006033 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 198094006034 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 198094006035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094006036 RNA binding surface [nucleotide binding]; other site 198094006037 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 198094006038 probable active site [active] 198094006039 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 198094006040 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 198094006041 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 198094006042 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 198094006043 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 198094006044 active site 198094006045 dimer interface [polypeptide binding]; other site 198094006046 motif 1; other site 198094006047 motif 2; other site 198094006048 motif 3; other site 198094006049 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 198094006050 anticodon binding site; other site 198094006051 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094006052 FtsX-like permease family; Region: FtsX; pfam02687 198094006053 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094006054 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094006055 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094006056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006057 putative substrate translocation pore; other site 198094006058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094006059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094006060 dimer interface [polypeptide binding]; other site 198094006061 conserved gate region; other site 198094006062 ABC-ATPase subunit interface; other site 198094006063 ZIP Zinc transporter; Region: Zip; cl00437 198094006064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006065 S-adenosylmethionine binding site [chemical binding]; other site 198094006066 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl19625 198094006067 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 198094006068 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094006069 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 198094006070 active site 198094006071 dimerization interface [polypeptide binding]; other site 198094006072 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 198094006073 multidrug resistance protein (mdr1); Provisional; Region: PTZ00265 198094006074 Bacterial PH domain; Region: bPH_3; pfam14470 198094006075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006076 Coenzyme A binding pocket [chemical binding]; other site 198094006077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094006078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094006079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094006080 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 198094006081 Transport protein; Region: actII; TIGR00833 198094006082 MMPL family; Region: MMPL; cl14618 198094006083 MMPL family; Region: MMPL; cl14618 198094006084 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 198094006085 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 198094006086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006087 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198094006088 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094006089 Coenzyme A binding pocket [chemical binding]; other site 198094006090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094006091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006092 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 198094006093 Coenzyme A binding pocket [chemical binding]; other site 198094006094 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198094006095 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 198094006096 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198094006097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094006098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006099 Coenzyme A binding pocket [chemical binding]; other site 198094006100 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094006101 EamA-like transporter family; Region: EamA; pfam00892 198094006102 EamA-like transporter family; Region: EamA; pfam00892 198094006103 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 198094006104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094006105 non-specific DNA binding site [nucleotide binding]; other site 198094006106 salt bridge; other site 198094006107 sequence-specific DNA binding site [nucleotide binding]; other site 198094006108 Cupin domain; Region: Cupin_2; pfam07883 198094006109 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 198094006110 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094006111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094006112 protoporphyrinogen oxidase; Provisional; Region: PRK12416 198094006113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198094006114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094006115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094006116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094006117 Cold-inducible protein YdjO; Region: YdjO; pfam14169 198094006118 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198094006119 DNA-binding site [nucleotide binding]; DNA binding site 198094006120 RNA-binding motif; other site 198094006121 AAA domain; Region: AAA_18; pfam13238 198094006122 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 198094006123 active site 198094006124 metal binding site [ion binding]; metal-binding site 198094006125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094006126 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 198094006127 active site 198094006128 motif I; other site 198094006129 motif II; other site 198094006130 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094006131 hypothetical protein; Provisional; Region: PRK06770 198094006132 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 198094006133 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 198094006134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094006135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094006136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198094006137 dimerization interface [polypeptide binding]; other site 198094006138 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 198094006139 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 198094006140 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 198094006141 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 198094006142 active site 198094006143 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 198094006144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094006145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198094006146 dimerization interface [polypeptide binding]; other site 198094006147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 198094006148 MOSC domain; Region: MOSC; pfam03473 198094006149 3-alpha domain; Region: 3-alpha; pfam03475 198094006150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006151 Coenzyme A binding pocket [chemical binding]; other site 198094006152 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 198094006153 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 198094006154 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094006155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094006156 Walker A/P-loop; other site 198094006157 ATP binding site [chemical binding]; other site 198094006158 Q-loop/lid; other site 198094006159 ABC transporter signature motif; other site 198094006160 Walker B; other site 198094006161 D-loop; other site 198094006162 H-loop/switch region; other site 198094006163 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 198094006164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094006165 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 198094006166 Walker A/P-loop; other site 198094006167 ATP binding site [chemical binding]; other site 198094006168 Q-loop/lid; other site 198094006169 ABC transporter signature motif; other site 198094006170 Walker B; other site 198094006171 D-loop; other site 198094006172 H-loop/switch region; other site 198094006173 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198094006174 active site 198094006175 metal binding site [ion binding]; metal-binding site 198094006176 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 198094006177 LysE type translocator; Region: LysE; cl00565 198094006178 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 198094006179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094006180 non-specific DNA binding site [nucleotide binding]; other site 198094006181 salt bridge; other site 198094006182 sequence-specific DNA binding site [nucleotide binding]; other site 198094006183 Cupin domain; Region: Cupin_2; pfam07883 198094006184 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 198094006185 BclB C-terminal domain; Region: exospore_TM; TIGR03721 198094006186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198094006187 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 198094006188 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 198094006189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094006190 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 198094006191 DNA binding residues [nucleotide binding] 198094006192 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094006193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006194 S-adenosylmethionine binding site [chemical binding]; other site 198094006195 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 198094006196 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 198094006197 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 198094006198 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 198094006199 active site 198094006200 P-loop; other site 198094006201 phosphorylation site [posttranslational modification] 198094006202 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 198094006203 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 198094006204 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198094006205 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 198094006206 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 198094006207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 198094006208 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 198094006209 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094006210 catalytic residue [active] 198094006211 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 198094006212 tetramer interface [polypeptide binding]; other site 198094006213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094006214 catalytic residue [active] 198094006215 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198094006216 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 198094006217 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198094006218 ATP binding site [chemical binding]; other site 198094006219 Mg++ binding site [ion binding]; other site 198094006220 motif III; other site 198094006221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094006222 nucleotide binding region [chemical binding]; other site 198094006223 ATP-binding site [chemical binding]; other site 198094006224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094006225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094006226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006227 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094006228 putative substrate translocation pore; other site 198094006229 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094006230 FtsX-like permease family; Region: FtsX; pfam02687 198094006231 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094006232 FtsX-like permease family; Region: FtsX; pfam02687 198094006233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094006234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094006235 Walker A/P-loop; other site 198094006236 ATP binding site [chemical binding]; other site 198094006237 Q-loop/lid; other site 198094006238 ABC transporter signature motif; other site 198094006239 Walker B; other site 198094006240 D-loop; other site 198094006241 H-loop/switch region; other site 198094006242 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094006243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006244 S-adenosylmethionine binding site [chemical binding]; other site 198094006245 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 198094006246 dimer interface [polypeptide binding]; other site 198094006247 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094006248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006249 S-adenosylmethionine binding site [chemical binding]; other site 198094006250 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 198094006251 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 198094006252 dimer interface [polypeptide binding]; other site 198094006253 PYR/PP interface [polypeptide binding]; other site 198094006254 TPP binding site [chemical binding]; other site 198094006255 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198094006256 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 198094006257 TPP-binding site [chemical binding]; other site 198094006258 dimer interface [polypeptide binding]; other site 198094006259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 198094006260 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094006261 putative DNA binding site [nucleotide binding]; other site 198094006262 putative Zn2+ binding site [ion binding]; other site 198094006263 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198094006264 catalytic core [active] 198094006265 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 198094006266 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 198094006267 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 198094006268 metal binding site [ion binding]; metal-binding site 198094006269 dimer interface [polypeptide binding]; other site 198094006270 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 198094006271 active site 198094006272 catalytic triad [active] 198094006273 oxyanion hole [active] 198094006274 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 198094006275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094006276 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094006277 DNA binding residues [nucleotide binding] 198094006278 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 198094006279 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198094006280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094006281 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094006282 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 198094006283 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 198094006284 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198094006285 active site 198094006286 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094006287 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094006288 DNA binding site [nucleotide binding] 198094006289 domain linker motif; other site 198094006290 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 198094006291 ligand binding site [chemical binding]; other site 198094006292 dimerization interface [polypeptide binding]; other site 198094006293 polyol permease family; Region: 2A0118; TIGR00897 198094006294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006295 putative substrate translocation pore; other site 198094006296 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198094006297 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198094006298 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198094006299 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 198094006300 substrate binding site [chemical binding]; other site 198094006301 ATP binding site [chemical binding]; other site 198094006302 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 198094006303 tetrameric interface [polypeptide binding]; other site 198094006304 NAD binding site [chemical binding]; other site 198094006305 catalytic residues [active] 198094006306 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 198094006307 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198094006308 PYR/PP interface [polypeptide binding]; other site 198094006309 dimer interface [polypeptide binding]; other site 198094006310 TPP binding site [chemical binding]; other site 198094006311 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198094006312 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 198094006313 TPP-binding site; other site 198094006314 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 198094006315 intersubunit interface [polypeptide binding]; other site 198094006316 active site 198094006317 zinc binding site [ion binding]; other site 198094006318 Na+ binding site [ion binding]; other site 198094006319 KduI/IolB family; Region: KduI; pfam04962 198094006320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094006321 TPR motif; other site 198094006322 binding surface 198094006323 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094006324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094006325 salt bridge; other site 198094006326 non-specific DNA binding site [nucleotide binding]; other site 198094006327 sequence-specific DNA binding site [nucleotide binding]; other site 198094006328 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 198094006329 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 198094006330 S-layer homology domain; Region: SLH; pfam00395 198094006331 S-layer homology domain; Region: SLH; pfam00395 198094006332 S-layer homology domain; Region: SLH; pfam00395 198094006333 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 198094006334 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198094006335 active site 198094006336 metal binding site [ion binding]; metal-binding site 198094006337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094006338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094006339 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 198094006340 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094006341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094006342 PAS domain; Region: PAS_9; pfam13426 198094006343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094006344 putative active site [active] 198094006345 heme pocket [chemical binding]; other site 198094006346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198094006347 metal binding site [ion binding]; metal-binding site 198094006348 active site 198094006349 I-site; other site 198094006350 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198094006351 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094006352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094006353 SMI1-KNR4 cell-wall; Region: SUKH_6; pfam14568 198094006354 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 198094006355 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198094006356 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 198094006357 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198094006358 active site residue [active] 198094006359 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 198094006360 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198094006361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094006362 Walker A/P-loop; other site 198094006363 ATP binding site [chemical binding]; other site 198094006364 Q-loop/lid; other site 198094006365 ABC transporter signature motif; other site 198094006366 Walker B; other site 198094006367 D-loop; other site 198094006368 H-loop/switch region; other site 198094006369 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198094006370 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 198094006371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094006372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094006373 Protein of unknown function (DUF523); Region: DUF523; pfam04463 198094006374 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 198094006375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 198094006376 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 198094006377 FAD binding site [chemical binding]; other site 198094006378 homotetramer interface [polypeptide binding]; other site 198094006379 substrate binding pocket [chemical binding]; other site 198094006380 catalytic base [active] 198094006381 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 198094006382 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198094006383 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198094006384 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 198094006385 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198094006386 carboxyltransferase (CT) interaction site; other site 198094006387 biotinylation site [posttranslational modification]; other site 198094006388 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 198094006389 active site 198094006390 catalytic residues [active] 198094006391 metal binding site [ion binding]; metal-binding site 198094006392 enoyl-CoA hydratase; Provisional; Region: PRK07657 198094006393 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198094006394 substrate binding site [chemical binding]; other site 198094006395 oxyanion hole (OAH) forming residues; other site 198094006396 trimer interface [polypeptide binding]; other site 198094006397 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 198094006398 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 198094006399 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 198094006400 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 198094006401 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 198094006402 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 198094006403 acyl-activating enzyme (AAE) consensus motif; other site 198094006404 putative AMP binding site [chemical binding]; other site 198094006405 putative active site [active] 198094006406 putative CoA binding site [chemical binding]; other site 198094006407 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094006408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006409 Coenzyme A binding pocket [chemical binding]; other site 198094006410 hypothetical protein; Provisional; Region: PRK08233 198094006411 active site 198094006412 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094006413 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094006414 DinB family; Region: DinB; cl17821 198094006415 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198094006416 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094006417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094006418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094006419 dimer interface [polypeptide binding]; other site 198094006420 phosphorylation site [posttranslational modification] 198094006421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094006422 ATP binding site [chemical binding]; other site 198094006423 Mg2+ binding site [ion binding]; other site 198094006424 G-X-G motif; other site 198094006425 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094006426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094006427 active site 198094006428 phosphorylation site [posttranslational modification] 198094006429 intermolecular recognition site; other site 198094006430 dimerization interface [polypeptide binding]; other site 198094006431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094006432 DNA binding site [nucleotide binding] 198094006433 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094006434 Zn2+ binding site [ion binding]; other site 198094006435 Mg2+ binding site [ion binding]; other site 198094006436 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 198094006437 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 198094006438 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 198094006439 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198094006440 NAD binding site [chemical binding]; other site 198094006441 substrate binding site [chemical binding]; other site 198094006442 putative active site [active] 198094006443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006444 Coenzyme A binding pocket [chemical binding]; other site 198094006445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094006446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006447 Coenzyme A binding pocket [chemical binding]; other site 198094006448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 198094006449 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 198094006450 putative hydrophobic ligand binding site [chemical binding]; other site 198094006451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094006452 Walker A/P-loop; other site 198094006453 ATP binding site [chemical binding]; other site 198094006454 Q-loop/lid; other site 198094006455 ABC transporter signature motif; other site 198094006456 Walker B; other site 198094006457 D-loop; other site 198094006458 H-loop/switch region; other site 198094006459 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 198094006460 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 198094006461 AAA domain; Region: AAA_22; pfam13401 198094006462 Predicted transcriptional regulators [Transcription]; Region: COG1695 198094006463 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094006464 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094006465 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 198094006466 DNA binding residues [nucleotide binding] 198094006467 drug binding residues [chemical binding]; other site 198094006468 dimer interface [polypeptide binding]; other site 198094006469 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 198094006470 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094006471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006472 putative substrate translocation pore; other site 198094006473 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 198094006474 nudix motif; other site 198094006475 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 198094006476 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 198094006477 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094006478 active site 198094006479 substrate binding site [chemical binding]; other site 198094006480 Phosphotransferase enzyme family; Region: APH; pfam01636 198094006481 ATP binding site [chemical binding]; other site 198094006482 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 198094006483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094006484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094006485 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 198094006486 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 198094006487 active site 198094006488 Zn binding site [ion binding]; other site 198094006489 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 198094006490 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198094006491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094006492 DNA-binding site [nucleotide binding]; DNA binding site 198094006493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094006494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094006495 homodimer interface [polypeptide binding]; other site 198094006496 catalytic residue [active] 198094006497 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198094006498 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 198094006499 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 198094006500 putative NAD(P) binding site [chemical binding]; other site 198094006501 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094006502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006503 S-adenosylmethionine binding site [chemical binding]; other site 198094006504 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094006505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006506 S-adenosylmethionine binding site [chemical binding]; other site 198094006507 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 198094006508 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 198094006509 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094006510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094006511 active site 198094006512 phosphorylation site [posttranslational modification] 198094006513 intermolecular recognition site; other site 198094006514 dimerization interface [polypeptide binding]; other site 198094006515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094006516 DNA binding site [nucleotide binding] 198094006517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094006518 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094006519 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 198094006520 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094006521 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094006522 Walker A/P-loop; other site 198094006523 ATP binding site [chemical binding]; other site 198094006524 Q-loop/lid; other site 198094006525 ABC transporter signature motif; other site 198094006526 Walker B; other site 198094006527 D-loop; other site 198094006528 H-loop/switch region; other site 198094006529 hypothetical protein; Provisional; Region: PRK06760 198094006530 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 198094006531 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094006532 homoserine dehydrogenase; Validated; Region: PRK06813 198094006533 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198094006534 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198094006535 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198094006536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094006537 DNA-binding site [nucleotide binding]; DNA binding site 198094006538 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094006539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094006540 homodimer interface [polypeptide binding]; other site 198094006541 catalytic residue [active] 198094006542 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 198094006543 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 198094006544 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198094006545 Putative transcription activator [Transcription]; Region: TenA; COG0819 198094006546 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 198094006547 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 198094006548 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 198094006549 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 198094006550 Protein of unknown function; Region: DUF3658; pfam12395 198094006551 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 198094006552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006553 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094006554 putative substrate translocation pore; other site 198094006555 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 198094006556 trimer interface [polypeptide binding]; other site 198094006557 active site 198094006558 substrate binding site [chemical binding]; other site 198094006559 CoA binding site [chemical binding]; other site 198094006560 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 198094006561 Predicted transcriptional regulators [Transcription]; Region: COG1695 198094006562 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 198094006563 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 198094006564 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094006565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094006566 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 198094006567 active site 198094006568 motif I; other site 198094006569 motif II; other site 198094006570 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094006571 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 198094006572 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198094006573 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094006574 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 198094006575 glycosyltransferase, MGT family; Region: MGT; TIGR01426 198094006576 active site 198094006577 TDP-binding site; other site 198094006578 acceptor substrate-binding pocket; other site 198094006579 homodimer interface [polypeptide binding]; other site 198094006580 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 198094006581 hypothetical protein; Provisional; Region: PRK13661 198094006582 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198094006583 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198094006584 Walker A/P-loop; other site 198094006585 ATP binding site [chemical binding]; other site 198094006586 Q-loop/lid; other site 198094006587 ABC transporter signature motif; other site 198094006588 Walker B; other site 198094006589 D-loop; other site 198094006590 H-loop/switch region; other site 198094006591 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 198094006592 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198094006593 Walker A/P-loop; other site 198094006594 ATP binding site [chemical binding]; other site 198094006595 Q-loop/lid; other site 198094006596 ABC transporter signature motif; other site 198094006597 Walker B; other site 198094006598 D-loop; other site 198094006599 H-loop/switch region; other site 198094006600 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 198094006601 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198094006602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094006603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094006604 dimer interface [polypeptide binding]; other site 198094006605 phosphorylation site [posttranslational modification] 198094006606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094006607 ATP binding site [chemical binding]; other site 198094006608 Mg2+ binding site [ion binding]; other site 198094006609 G-X-G motif; other site 198094006610 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 198094006611 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 198094006612 active site 198094006613 ATP binding site [chemical binding]; other site 198094006614 substrate binding site [chemical binding]; other site 198094006615 activation loop (A-loop); other site 198094006616 GrpB protein; Region: GrpB; pfam04229 198094006617 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198094006618 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 198094006619 NAD(P) binding site [chemical binding]; other site 198094006620 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 198094006621 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198094006622 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094006623 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 198094006624 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 198094006625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006626 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094006627 putative substrate translocation pore; other site 198094006628 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 198094006629 putative acetyltransferase; Provisional; Region: PRK03624 198094006630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006631 Coenzyme A binding pocket [chemical binding]; other site 198094006632 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 198094006633 EDD domain protein, DegV family; Region: DegV; TIGR00762 198094006634 DJ-1 family protein; Region: not_thiJ; TIGR01383 198094006635 Putative amidotransferase; Region: DUF4066; pfam13278 198094006636 conserved cys residue [active] 198094006637 Predicted transcriptional regulator [Transcription]; Region: COG2378 198094006638 HTH domain; Region: HTH_11; pfam08279 198094006639 WYL domain; Region: WYL; pfam13280 198094006640 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 198094006641 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 198094006642 conserved cys residue [active] 198094006643 Protein of unknown function (DUF975); Region: DUF975; cl10504 198094006644 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094006645 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094006646 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 198094006647 DNA binding residues [nucleotide binding] 198094006648 putative dimer interface [polypeptide binding]; other site 198094006649 Trm112p-like protein; Region: Trm112p; pfam03966 198094006650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006651 S-adenosylmethionine binding site [chemical binding]; other site 198094006652 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094006653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006654 putative substrate translocation pore; other site 198094006655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006656 Coenzyme A binding pocket [chemical binding]; other site 198094006657 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 198094006658 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 198094006659 active site 198094006660 catalytic site [active] 198094006661 metal binding site [ion binding]; metal-binding site 198094006662 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 198094006663 EamA-like transporter family; Region: EamA; pfam00892 198094006664 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 198094006665 EamA-like transporter family; Region: EamA; pfam00892 198094006666 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 198094006667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006668 Coenzyme A binding pocket [chemical binding]; other site 198094006669 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 198094006670 nudix motif; other site 198094006671 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 198094006672 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094006673 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 198094006674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094006675 putative substrate translocation pore; other site 198094006676 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 198094006677 nudix motif; other site 198094006678 DNA polymerase III subunit beta; Validated; Region: PRK06673 198094006679 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 198094006680 putative DNA binding surface [nucleotide binding]; other site 198094006681 dimer interface [polypeptide binding]; other site 198094006682 beta-clamp/clamp loader binding surface; other site 198094006683 beta-clamp/translesion DNA polymerase binding surface; other site 198094006684 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 198094006685 putative active site [active] 198094006686 nucleotide binding site [chemical binding]; other site 198094006687 nudix motif; other site 198094006688 putative metal binding site [ion binding]; other site 198094006689 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 198094006690 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 198094006691 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094006692 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 198094006693 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 198094006694 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 198094006695 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198094006696 homotrimer interaction site [polypeptide binding]; other site 198094006697 putative active site [active] 198094006698 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 198094006699 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 198094006700 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 198094006701 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 198094006702 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 198094006703 YxiJ-like protein; Region: YxiJ; pfam14176 198094006704 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 198094006705 pentamer interface [polypeptide binding]; other site 198094006706 dodecaamer interface [polypeptide binding]; other site 198094006707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006708 Coenzyme A binding pocket [chemical binding]; other site 198094006709 metal-dependent hydrolase; Provisional; Region: PRK13291 198094006710 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094006711 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094006712 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 198094006713 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 198094006714 GIY-YIG motif/motif A; other site 198094006715 active site 198094006716 catalytic site [active] 198094006717 putative DNA binding site [nucleotide binding]; other site 198094006718 metal binding site [ion binding]; metal-binding site 198094006719 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 198094006720 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 198094006721 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 198094006722 active site 198094006723 ATP binding site [chemical binding]; other site 198094006724 substrate binding site [chemical binding]; other site 198094006725 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 198094006726 nudix motif; other site 198094006727 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 198094006728 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 198094006729 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094006730 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 198094006731 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 198094006732 MepB protein; Region: MepB; pfam08877 198094006733 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 198094006734 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 198094006735 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 198094006736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094006737 motif II; other site 198094006738 DinB superfamily; Region: DinB_2; pfam12867 198094006739 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 198094006740 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094006741 catalytic residue [active] 198094006742 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 198094006743 putative FMN binding site [chemical binding]; other site 198094006744 NADPH bind site [chemical binding]; other site 198094006745 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 198094006746 carbohydrate binding site [chemical binding]; other site 198094006747 pullulanase, type I; Region: pulA_typeI; TIGR02104 198094006748 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 198094006749 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 198094006750 Ca binding site [ion binding]; other site 198094006751 active site 198094006752 catalytic site [active] 198094006753 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 198094006754 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 198094006755 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 198094006756 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 198094006757 active site 198094006758 Zn binding site [ion binding]; other site 198094006759 Putative zinc-finger; Region: zf-HC2; pfam13490 198094006760 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 198094006761 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 198094006762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094006763 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 198094006764 DNA binding residues [nucleotide binding] 198094006765 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 198094006766 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 198094006767 SecY translocase; Region: SecY; pfam00344 198094006768 hypothetical protein; Validated; Region: PRK06672 198094006769 DnaA N-terminal domain; Region: DnaA_N; pfam11638 198094006770 DnaA N-terminal domain; Region: DnaA_N; pfam11638 198094006771 DnaA N-terminal domain; Region: DnaA_N; pfam11638 198094006772 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 198094006773 EamA-like transporter family; Region: EamA; pfam00892 198094006774 EamA-like transporter family; Region: EamA; pfam00892 198094006775 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198094006776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094006777 DNA-binding site [nucleotide binding]; DNA binding site 198094006778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094006779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094006780 homodimer interface [polypeptide binding]; other site 198094006781 catalytic residue [active] 198094006782 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094006783 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094006784 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 198094006785 Mg binding site [ion binding]; other site 198094006786 nucleotide binding site [chemical binding]; other site 198094006787 putative protofilament interface [polypeptide binding]; other site 198094006788 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 198094006789 Predicted membrane protein [Function unknown]; Region: COG4129 198094006790 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 198094006791 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094006792 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 198094006793 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 198094006794 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 198094006795 germination protein YpeB; Region: spore_YpeB; TIGR02889 198094006796 YpeB sporulation; Region: YPEB; pfam14620 198094006797 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 198094006798 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198094006799 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 198094006800 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 198094006801 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 198094006802 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 198094006803 arylformamidase; Region: trp_arylform; TIGR03035 198094006804 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 198094006805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094006806 catalytic residue [active] 198094006807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094006808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094006809 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 198094006810 nudix motif; other site 198094006811 N-acetyltransferase; Region: Acetyltransf_2; cl00949 198094006812 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 198094006813 hydrophobic ligand binding site; other site 198094006814 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 198094006815 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 198094006816 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 198094006817 GAF domain; Region: GAF; pfam01590 198094006818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094006819 Walker A motif; other site 198094006820 ATP binding site [chemical binding]; other site 198094006821 Walker B motif; other site 198094006822 arginine finger; other site 198094006823 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198094006824 NIPSNAP; Region: NIPSNAP; pfam07978 198094006825 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094006826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006827 Coenzyme A binding pocket [chemical binding]; other site 198094006828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094006829 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198094006830 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 198094006831 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198094006832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006833 S-adenosylmethionine binding site [chemical binding]; other site 198094006834 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 198094006835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094006836 Predicted transcriptional regulator [Transcription]; Region: COG1959 198094006837 Rrf2 family protein; Region: rrf2_super; TIGR00738 198094006838 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 198094006839 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 198094006840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094006841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094006842 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 198094006843 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 198094006844 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198094006845 E3 interaction surface; other site 198094006846 lipoyl attachment site [posttranslational modification]; other site 198094006847 e3 binding domain; Region: E3_binding; pfam02817 198094006848 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198094006849 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 198094006850 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 198094006851 alpha subunit interface [polypeptide binding]; other site 198094006852 TPP binding site [chemical binding]; other site 198094006853 heterodimer interface [polypeptide binding]; other site 198094006854 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198094006855 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 198094006856 tetramer interface [polypeptide binding]; other site 198094006857 TPP-binding site [chemical binding]; other site 198094006858 heterodimer interface [polypeptide binding]; other site 198094006859 phosphorylation loop region [posttranslational modification] 198094006860 DinB superfamily; Region: DinB_2; pfam12867 198094006861 short chain dehydrogenase; Provisional; Region: PRK06914 198094006862 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 198094006863 NADP binding site [chemical binding]; other site 198094006864 active site 198094006865 steroid binding site; other site 198094006866 GrpB protein; Region: GrpB; pfam04229 198094006867 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 198094006868 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 198094006869 nudix motif; other site 198094006870 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 198094006871 Protein phosphatase 2C; Region: PP2C_2; pfam13672 198094006872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094006873 dimer interface [polypeptide binding]; other site 198094006874 conserved gate region; other site 198094006875 putative PBP binding loops; other site 198094006876 ABC-ATPase subunit interface; other site 198094006877 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 198094006878 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 198094006879 Walker A/P-loop; other site 198094006880 ATP binding site [chemical binding]; other site 198094006881 Q-loop/lid; other site 198094006882 ABC transporter signature motif; other site 198094006883 Walker B; other site 198094006884 D-loop; other site 198094006885 H-loop/switch region; other site 198094006886 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 198094006887 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 198094006888 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 198094006889 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 198094006890 oligomer interface [polypeptide binding]; other site 198094006891 active site residues [active] 198094006892 RNA polymerase factor sigma-70; Validated; Region: PRK06704 198094006893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094006894 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 198094006895 DNA binding residues [nucleotide binding] 198094006896 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198094006897 catalytic loop [active] 198094006898 iron binding site [ion binding]; other site 198094006899 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 198094006900 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198094006901 active site 198094006902 dimer interface [polypeptide binding]; other site 198094006903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006904 Coenzyme A binding pocket [chemical binding]; other site 198094006905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 198094006906 Chitin binding domain; Region: Chitin_bind_3; pfam03067 198094006907 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198094006908 Interdomain contacts; other site 198094006909 Cytokine receptor motif; other site 198094006910 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198094006911 Interdomain contacts; other site 198094006912 Cytokine receptor motif; other site 198094006913 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 198094006914 topology modulation protein; Reviewed; Region: PRK08118 198094006915 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 198094006916 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 198094006917 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 198094006918 Protein of unknown function; Region: DUF3658; pfam12395 198094006919 YjbR; Region: YjbR; pfam04237 198094006920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006921 Coenzyme A binding pocket [chemical binding]; other site 198094006922 S-layer homology domain; Region: SLH; pfam00395 198094006923 S-layer homology domain; Region: SLH; pfam00395 198094006924 S-layer homology domain; Region: SLH; pfam00395 198094006925 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 198094006926 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094006927 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 198094006928 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 198094006929 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 198094006930 active site 198094006931 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 198094006932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006933 Coenzyme A binding pocket [chemical binding]; other site 198094006934 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 198094006935 Predicted transcriptional regulators [Transcription]; Region: COG1695 198094006936 Protein of unknown function (DUF952); Region: DUF952; pfam06108 198094006937 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 198094006938 Part of AAA domain; Region: AAA_19; pfam13245 198094006939 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198094006940 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 198094006941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094006942 S-adenosylmethionine binding site [chemical binding]; other site 198094006943 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 198094006944 putative active site pocket [active] 198094006945 dimerization interface [polypeptide binding]; other site 198094006946 putative catalytic residue [active] 198094006947 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 198094006948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094006949 ATP binding site [chemical binding]; other site 198094006950 putative Mg++ binding site [ion binding]; other site 198094006951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094006952 nucleotide binding region [chemical binding]; other site 198094006953 ATP-binding site [chemical binding]; other site 198094006954 RQC domain; Region: RQC; pfam09382 198094006955 HRDC domain; Region: HRDC; pfam00570 198094006956 Helix-turn-helix domain; Region: HTH_40; pfam14493 198094006957 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 198094006958 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 198094006959 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 198094006960 active site 198094006961 Zn binding site [ion binding]; other site 198094006962 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 198094006963 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 198094006964 DHHA2 domain; Region: DHHA2; pfam02833 198094006965 Chitin binding domain; Region: Chitin_bind_3; pfam03067 198094006966 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198094006967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094006968 Coenzyme A binding pocket [chemical binding]; other site 198094006969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094006970 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 198094006971 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 198094006972 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 198094006973 NAD(P) binding site [chemical binding]; other site 198094006974 catalytic residues [active] 198094006975 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 198094006976 inhibitor site; inhibition site 198094006977 active site 198094006978 dimer interface [polypeptide binding]; other site 198094006979 catalytic residue [active] 198094006980 Proline racemase; Region: Pro_racemase; pfam05544 198094006981 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 198094006982 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 198094006983 Proline racemase; Region: Pro_racemase; pfam05544 198094006984 FAD dependent oxidoreductase; Region: DAO; pfam01266 198094006985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094006986 PAS domain; Region: PAS; smart00091 198094006987 PAS domain; Region: PAS_9; pfam13426 198094006988 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 198094006989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094006990 Walker A motif; other site 198094006991 ATP binding site [chemical binding]; other site 198094006992 Walker B motif; other site 198094006993 arginine finger; other site 198094006994 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198094006995 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 198094006996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094006997 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 198094006998 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 198094006999 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198094007000 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 198094007001 DltD N-terminal region; Region: DltD_N; pfam04915 198094007002 DltD central region; Region: DltD_M; pfam04918 198094007003 DltD C-terminal region; Region: DltD_C; pfam04914 198094007004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094007005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007006 Coenzyme A binding pocket [chemical binding]; other site 198094007007 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094007008 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094007009 peptide binding site [polypeptide binding]; other site 198094007010 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094007011 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198094007012 NlpC/P60 family; Region: NLPC_P60; pfam00877 198094007013 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 198094007014 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 198094007015 active site 198094007016 Septum formation initiator; Region: DivIC; pfam04977 198094007017 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 198094007018 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 198094007019 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198094007020 active site 198094007021 catalytic motif [active] 198094007022 Zn binding site [ion binding]; other site 198094007023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094007024 S-adenosylmethionine binding site [chemical binding]; other site 198094007025 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 198094007026 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 198094007027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 198094007028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094007029 dimerization interface [polypeptide binding]; other site 198094007030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094007031 dimer interface [polypeptide binding]; other site 198094007032 phosphorylation site [posttranslational modification] 198094007033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094007034 ATP binding site [chemical binding]; other site 198094007035 Mg2+ binding site [ion binding]; other site 198094007036 G-X-G motif; other site 198094007037 Flagellar protein (FlbD); Region: FlbD; cl00683 198094007038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094007039 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 198094007040 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 198094007041 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094007042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094007043 motif II; other site 198094007044 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094007045 Phosphotransferase enzyme family; Region: APH; pfam01636 198094007046 active site 198094007047 substrate binding site [chemical binding]; other site 198094007048 ATP binding site [chemical binding]; other site 198094007049 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 198094007050 EDD domain protein, DegV family; Region: DegV; TIGR00762 198094007051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007052 Coenzyme A binding pocket [chemical binding]; other site 198094007053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094007054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094007056 putative substrate translocation pore; other site 198094007057 Protein of unknown function (DUF342); Region: DUF342; cl19219 198094007058 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 198094007059 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 198094007060 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 198094007061 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 198094007062 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 198094007063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094007065 putative substrate translocation pore; other site 198094007066 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 198094007067 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 198094007068 Predicted membrane protein [Function unknown]; Region: COG2261 198094007069 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 198094007070 active site 198094007071 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 198094007072 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094007073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094007074 S-adenosylmethionine binding site [chemical binding]; other site 198094007075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007076 putative substrate translocation pore; other site 198094007077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094007078 aspartate aminotransferase; Provisional; Region: PRK07681 198094007079 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094007080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094007081 homodimer interface [polypeptide binding]; other site 198094007082 catalytic residue [active] 198094007083 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 198094007084 pantothenate kinase; Provisional; Region: PRK13317 198094007085 CAAX protease self-immunity; Region: Abi; pfam02517 198094007086 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 198094007087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094007088 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198094007089 Walker A/P-loop; other site 198094007090 ATP binding site [chemical binding]; other site 198094007091 Q-loop/lid; other site 198094007092 ABC transporter signature motif; other site 198094007093 Walker B; other site 198094007094 D-loop; other site 198094007095 H-loop/switch region; other site 198094007096 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 198094007097 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 198094007098 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 198094007099 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 198094007100 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 198094007101 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 198094007102 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 198094007103 HNH endonuclease; Region: HNH_5; pfam14279 198094007104 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 198094007105 active site 198094007106 dimer interface [polypeptide binding]; other site 198094007107 non-prolyl cis peptide bond; other site 198094007108 insertion regions; other site 198094007109 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198094007110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094007111 dimer interface [polypeptide binding]; other site 198094007112 conserved gate region; other site 198094007113 putative PBP binding loops; other site 198094007114 ABC-ATPase subunit interface; other site 198094007115 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 198094007116 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198094007117 substrate binding pocket [chemical binding]; other site 198094007118 membrane-bound complex binding site; other site 198094007119 hinge residues; other site 198094007120 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198094007121 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198094007122 Walker A/P-loop; other site 198094007123 ATP binding site [chemical binding]; other site 198094007124 Q-loop/lid; other site 198094007125 ABC transporter signature motif; other site 198094007126 Walker B; other site 198094007127 D-loop; other site 198094007128 H-loop/switch region; other site 198094007129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094007130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094007131 Protein of unknown function (DUF402); Region: DUF402; pfam04167 198094007132 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 198094007133 nudix motif; other site 198094007134 Tetratrico peptide repeat; Region: TPR_5; pfam12688 198094007135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094007136 binding surface 198094007137 TPR motif; other site 198094007138 hypothetical protein; Provisional; Region: PRK09620 198094007139 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 198094007140 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 198094007141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007142 ESCO1/2 acetyl-transferase; Region: Acetyltransf_13; pfam13880 198094007143 Coenzyme A binding pocket [chemical binding]; other site 198094007144 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 198094007145 DinB superfamily; Region: DinB_2; pfam12867 198094007146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094007147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007148 Coenzyme A binding pocket [chemical binding]; other site 198094007149 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094007150 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094007151 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 198094007152 active site 198094007153 NTP binding site [chemical binding]; other site 198094007154 metal binding triad [ion binding]; metal-binding site 198094007155 antibiotic binding site [chemical binding]; other site 198094007156 A new structural DNA glycosylase; Region: AlkD_like; cd06561 198094007157 active site 198094007158 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 198094007159 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 198094007160 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 198094007161 NodB motif; other site 198094007162 active site 198094007163 catalytic site [active] 198094007164 Zn binding site [ion binding]; other site 198094007165 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 198094007166 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 198094007167 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 198094007168 Sulfatase; Region: Sulfatase; pfam00884 198094007169 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 198094007170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094007171 ABC transporter; Region: ABC_tran_2; pfam12848 198094007172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094007173 hypothetical protein; Provisional; Region: PRK06761 198094007174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094007175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094007176 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 198094007177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007178 Coenzyme A binding pocket [chemical binding]; other site 198094007179 Sterol carrier protein domain; Region: SCP2_2; pfam13530 198094007180 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 198094007181 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 198094007182 hinge; other site 198094007183 active site 198094007184 prephenate dehydrogenase; Validated; Region: PRK06545 198094007185 prephenate dehydrogenase; Validated; Region: PRK08507 198094007186 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 198094007187 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 198094007188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094007189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094007190 homodimer interface [polypeptide binding]; other site 198094007191 catalytic residue [active] 198094007192 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 198094007193 Tetramer interface [polypeptide binding]; other site 198094007194 active site 198094007195 FMN-binding site [chemical binding]; other site 198094007196 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 198094007197 Chorismate mutase type II; Region: CM_2; cl00693 198094007198 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 198094007199 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 198094007200 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 198094007201 catalytic triad [active] 198094007202 conserved cis-peptide bond; other site 198094007203 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094007204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007205 Coenzyme A binding pocket [chemical binding]; other site 198094007206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094007207 YfzA-like protein; Region: YfzA; pfam14118 198094007208 hypothetical protein; Provisional; Region: PRK06762 198094007209 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 198094007210 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094007211 Bacterial SH3 domain homologues; Region: SH3b; smart00287 198094007212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 198094007213 RNA polymerase sigma factor; Provisional; Region: PRK12543 198094007214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094007215 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094007216 DNA binding residues [nucleotide binding] 198094007217 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 198094007218 malate:quinone oxidoreductase; Validated; Region: PRK05257 198094007219 Predicted dehydrogenase [General function prediction only]; Region: COG0579 198094007220 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 198094007221 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 198094007222 ligand binding site [chemical binding]; other site 198094007223 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198094007224 TM-ABC transporter signature motif; other site 198094007225 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198094007226 TM-ABC transporter signature motif; other site 198094007227 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198094007228 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198094007229 Walker A/P-loop; other site 198094007230 ATP binding site [chemical binding]; other site 198094007231 Q-loop/lid; other site 198094007232 ABC transporter signature motif; other site 198094007233 Walker B; other site 198094007234 D-loop; other site 198094007235 H-loop/switch region; other site 198094007236 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198094007237 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 198094007238 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 198094007239 Cupin domain; Region: Cupin_2; pfam07883 198094007240 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 198094007241 putative active site; other site 198094007242 catalytic residue [active] 198094007243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094007244 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094007245 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 198094007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007247 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094007248 putative substrate translocation pore; other site 198094007249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094007250 dimerization interface [polypeptide binding]; other site 198094007251 putative DNA binding site [nucleotide binding]; other site 198094007252 putative Zn2+ binding site [ion binding]; other site 198094007253 DinB superfamily; Region: DinB_2; pfam12867 198094007254 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198094007255 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198094007256 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198094007257 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 198094007258 putative catalytic cysteine [active] 198094007259 gamma-glutamyl kinase; Provisional; Region: PRK05429 198094007260 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 198094007261 nucleotide binding site [chemical binding]; other site 198094007262 homotetrameric interface [polypeptide binding]; other site 198094007263 putative phosphate binding site [ion binding]; other site 198094007264 putative allosteric binding site; other site 198094007265 PUA domain; Region: PUA; pfam01472 198094007266 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 198094007267 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 198094007268 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 198094007269 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 198094007270 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 198094007271 putative metal binding site [ion binding]; other site 198094007272 putative dimer interface [polypeptide binding]; other site 198094007273 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 198094007274 Transcriptional regulator [Transcription]; Region: IclR; COG1414 198094007275 Bacterial transcriptional regulator; Region: IclR; pfam01614 198094007276 S-methylmethionine transporter; Provisional; Region: PRK11387 198094007277 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094007278 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 198094007279 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 198094007280 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 198094007281 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 198094007282 putative di-iron ligands [ion binding]; other site 198094007283 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 198094007284 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 198094007285 dimer interface [polypeptide binding]; other site 198094007286 active site 198094007287 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 198094007288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094007289 salt bridge; other site 198094007290 non-specific DNA binding site [nucleotide binding]; other site 198094007291 sequence-specific DNA binding site [nucleotide binding]; other site 198094007292 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 198094007293 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 198094007294 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 198094007295 Protein of unknown function (DUF973); Region: DUF973; pfam06157 198094007296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094007297 ATP binding site [chemical binding]; other site 198094007298 Mg2+ binding site [ion binding]; other site 198094007299 G-X-G motif; other site 198094007300 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 198094007301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 198094007302 LytTr DNA-binding domain; Region: LytTR; pfam04397 198094007303 uridine kinase; Provisional; Region: PRK07667 198094007304 active site 198094007305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094007306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007307 Coenzyme A binding pocket [chemical binding]; other site 198094007308 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 198094007309 active site 198094007310 metal binding site [ion binding]; metal-binding site 198094007311 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 198094007312 Predicted transcriptional regulators [Transcription]; Region: COG1695 198094007313 MoxR-like ATPases [General function prediction only]; Region: COG0714 198094007314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094007315 Walker A motif; other site 198094007316 ATP binding site [chemical binding]; other site 198094007317 Walker B motif; other site 198094007318 arginine finger; other site 198094007319 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 198094007320 Protein of unknown function DUF58; Region: DUF58; pfam01882 198094007321 proline/glycine betaine transporter; Provisional; Region: PRK10642 198094007322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007323 putative substrate translocation pore; other site 198094007324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094007325 active site 198094007326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094007327 active site 198094007328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 198094007329 active site 198094007330 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 198094007331 Ligand binding site; other site 198094007332 Putative Catalytic site; other site 198094007333 DXD motif; other site 198094007334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094007335 active site 198094007336 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 198094007337 Ligand binding site; other site 198094007338 Putative Catalytic site; other site 198094007339 DXD motif; other site 198094007340 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198094007341 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094007342 inhibitor-cofactor binding pocket; inhibition site 198094007343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094007344 catalytic residue [active] 198094007345 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 198094007346 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 198094007347 tetramer interface [polypeptide binding]; other site 198094007348 heme binding pocket [chemical binding]; other site 198094007349 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 198094007350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198094007351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198094007352 active site 198094007353 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094007354 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 198094007355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 198094007356 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 198094007357 Protein of unknown function DUF58; Region: DUF58; pfam01882 198094007358 MoxR-like ATPases [General function prediction only]; Region: COG0714 198094007359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094007360 Walker A motif; other site 198094007361 ATP binding site [chemical binding]; other site 198094007362 Walker B motif; other site 198094007363 arginine finger; other site 198094007364 Uncharacterized conserved protein [Function unknown]; Region: COG1359 198094007365 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 198094007366 dimer interface [polypeptide binding]; other site 198094007367 FMN binding site [chemical binding]; other site 198094007368 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094007369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094007370 putative DNA binding site [nucleotide binding]; other site 198094007371 putative Zn2+ binding site [ion binding]; other site 198094007372 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 198094007373 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 198094007374 G1 box; other site 198094007375 putative GEF interaction site [polypeptide binding]; other site 198094007376 GTP/Mg2+ binding site [chemical binding]; other site 198094007377 Switch I region; other site 198094007378 G2 box; other site 198094007379 G3 box; other site 198094007380 Switch II region; other site 198094007381 G4 box; other site 198094007382 G5 box; other site 198094007383 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 198094007384 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 198094007385 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 198094007386 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 198094007387 nudix motif; other site 198094007388 YfzA-like protein; Region: YfzA; pfam14118 198094007389 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 198094007390 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094007391 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094007392 Walker A/P-loop; other site 198094007393 ATP binding site [chemical binding]; other site 198094007394 Q-loop/lid; other site 198094007395 ABC transporter signature motif; other site 198094007396 Walker B; other site 198094007397 D-loop; other site 198094007398 H-loop/switch region; other site 198094007399 Predicted transcriptional regulators [Transcription]; Region: COG1725 198094007400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094007401 DNA-binding site [nucleotide binding]; DNA binding site 198094007402 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 198094007403 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 198094007404 putative NAD(P) binding site [chemical binding]; other site 198094007405 active site 198094007406 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094007407 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094007408 Walker A/P-loop; other site 198094007409 ATP binding site [chemical binding]; other site 198094007410 Q-loop/lid; other site 198094007411 ABC transporter signature motif; other site 198094007412 Walker B; other site 198094007413 D-loop; other site 198094007414 H-loop/switch region; other site 198094007415 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198094007416 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094007417 FtsX-like permease family; Region: FtsX; pfam02687 198094007418 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094007419 FtsX-like permease family; Region: FtsX; pfam02687 198094007420 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 198094007421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094007422 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198094007423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094007424 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 198094007425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094007426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007427 Coenzyme A binding pocket [chemical binding]; other site 198094007428 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 198094007429 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 198094007430 nudix motif; other site 198094007431 EamA-like transporter family; Region: EamA; pfam00892 198094007432 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 198094007433 EamA-like transporter family; Region: EamA; pfam00892 198094007434 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198094007435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094007436 DNA-binding site [nucleotide binding]; DNA binding site 198094007437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094007438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094007439 homodimer interface [polypeptide binding]; other site 198094007440 catalytic residue [active] 198094007441 hypothetical protein; Validated; Region: PRK00124 198094007442 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 198094007443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094007444 HAMP domain; Region: HAMP; pfam00672 198094007445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094007446 dimer interface [polypeptide binding]; other site 198094007447 phosphorylation site [posttranslational modification] 198094007448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094007449 ATP binding site [chemical binding]; other site 198094007450 Mg2+ binding site [ion binding]; other site 198094007451 G-X-G motif; other site 198094007452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094007453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094007454 active site 198094007455 phosphorylation site [posttranslational modification] 198094007456 intermolecular recognition site; other site 198094007457 dimerization interface [polypeptide binding]; other site 198094007458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 198094007459 DNA binding site [nucleotide binding] 198094007460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094007461 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 198094007462 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 198094007463 uridine kinase; Validated; Region: PRK06696 198094007464 active site 198094007465 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 198094007466 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 198094007467 active site 198094007468 metal binding site [ion binding]; metal-binding site 198094007469 Phosphotransferase enzyme family; Region: APH; pfam01636 198094007470 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094007471 active site 198094007472 substrate binding site [chemical binding]; other site 198094007473 ATP binding site [chemical binding]; other site 198094007474 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 198094007475 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198094007476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094007477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007478 Coenzyme A binding pocket [chemical binding]; other site 198094007479 lysine transporter; Provisional; Region: PRK10836 198094007480 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094007481 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 198094007482 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 198094007483 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 198094007484 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 198094007485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094007486 S-adenosylmethionine binding site [chemical binding]; other site 198094007487 FMN-binding domain; Region: FMN_bind; cl01081 198094007488 Cephalosporin hydroxylase; Region: CmcI; pfam04989 198094007489 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 198094007490 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198094007491 Catalytic site [active] 198094007492 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 198094007493 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 198094007494 NAD+ binding site [chemical binding]; other site 198094007495 substrate binding site [chemical binding]; other site 198094007496 Zn binding site [ion binding]; other site 198094007497 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 198094007498 putative substrate binding pocket [chemical binding]; other site 198094007499 AC domain interface; other site 198094007500 catalytic triad [active] 198094007501 AB domain interface; other site 198094007502 interchain disulfide; other site 198094007503 Protein of unknown function (DUF979); Region: DUF979; pfam06166 198094007504 Protein of unknown function (DUF969); Region: DUF969; pfam06149 198094007505 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 198094007506 putative active site [active] 198094007507 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 198094007508 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 198094007509 Transcriptional regulator [Transcription]; Region: IclR; COG1414 198094007510 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 198094007511 Bacterial transcriptional regulator; Region: IclR; pfam01614 198094007512 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 198094007513 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198094007514 Catalytic site [active] 198094007515 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 198094007516 CutC family; Region: CutC; cl01218 198094007517 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 198094007518 stage II sporulation protein P; Region: spore_II_P; TIGR02867 198094007519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094007520 dimerization interface [polypeptide binding]; other site 198094007521 putative DNA binding site [nucleotide binding]; other site 198094007522 putative Zn2+ binding site [ion binding]; other site 198094007523 DinB superfamily; Region: DinB_2; pfam12867 198094007524 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 198094007525 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 198094007526 active site 198094007527 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 198094007528 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198094007529 putative active site [active] 198094007530 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094007531 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094007532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 198094007533 Nucleoside recognition; Region: Gate; pfam07670 198094007534 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 198094007535 Phosphotransferase enzyme family; Region: APH; pfam01636 198094007536 putative active site [active] 198094007537 putative substrate binding site [chemical binding]; other site 198094007538 ATP binding site [chemical binding]; other site 198094007539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007540 Coenzyme A binding pocket [chemical binding]; other site 198094007541 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 198094007542 Ferritin-like domain; Region: Ferritin; pfam00210 198094007543 dinuclear metal binding motif [ion binding]; other site 198094007544 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 198094007545 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 198094007546 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 198094007547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094007548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094007549 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 198094007550 phosphoenolpyruvate synthase; Validated; Region: PRK06241 198094007551 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 198094007552 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198094007553 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094007554 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 198094007555 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 198094007556 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 198094007557 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 198094007558 LysE type translocator; Region: LysE; cl00565 198094007559 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 198094007560 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 198094007561 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 198094007562 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 198094007563 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 198094007564 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198094007565 NAD binding site [chemical binding]; other site 198094007566 catalytic Zn binding site [ion binding]; other site 198094007567 structural Zn binding site [ion binding]; other site 198094007568 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 198094007569 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 198094007570 dimanganese center [ion binding]; other site 198094007571 aspartate ammonia-lyase; Provisional; Region: PRK14515 198094007572 Aspartase; Region: Aspartase; cd01357 198094007573 active sites [active] 198094007574 tetramer interface [polypeptide binding]; other site 198094007575 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 198094007576 active site 198094007577 homodimer interface [polypeptide binding]; other site 198094007578 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094007579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094007580 non-specific DNA binding site [nucleotide binding]; other site 198094007581 salt bridge; other site 198094007582 sequence-specific DNA binding site [nucleotide binding]; other site 198094007583 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 198094007584 GIY-YIG motif/motif A; other site 198094007585 active site 198094007586 catalytic site [active] 198094007587 putative DNA binding site [nucleotide binding]; other site 198094007588 metal binding site [ion binding]; metal-binding site 198094007589 amino acid transporter; Region: 2A0306; TIGR00909 198094007590 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094007591 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 198094007592 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 198094007593 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 198094007594 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 198094007595 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 198094007596 DoxX-like family; Region: DoxX_2; pfam13564 198094007597 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 198094007598 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198094007599 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 198094007600 putative NAD(P) binding site [chemical binding]; other site 198094007601 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 198094007602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094007603 active site 198094007604 phosphorylation site [posttranslational modification] 198094007605 intermolecular recognition site; other site 198094007606 dimerization interface [polypeptide binding]; other site 198094007607 YcbB domain; Region: YcbB; pfam08664 198094007608 glutaminase; Reviewed; Region: PRK12357 198094007609 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 198094007610 transmembrane helices; other site 198094007611 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 198094007612 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 198094007613 active site 198094007614 active site 198094007615 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 198094007616 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 198094007617 putative active site [active] 198094007618 putative metal binding site [ion binding]; other site 198094007619 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198094007620 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 198094007621 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 198094007622 tetramer interface [polypeptide binding]; other site 198094007623 heme binding pocket [chemical binding]; other site 198094007624 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094007625 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094007626 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094007627 TAP-like protein; Region: Abhydrolase_4; pfam08386 198094007628 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 198094007629 catalytic triad [active] 198094007630 dimer interface [polypeptide binding]; other site 198094007631 conserved cis-peptide bond; other site 198094007632 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 198094007633 catalytic triad [active] 198094007634 dimer interface [polypeptide binding]; other site 198094007635 conserved cis-peptide bond; other site 198094007636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 198094007637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094007638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094007639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198094007640 dimerization interface [polypeptide binding]; other site 198094007641 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 198094007642 Mg binding site [ion binding]; other site 198094007643 nucleotide binding site [chemical binding]; other site 198094007644 putative protofilament interface [polypeptide binding]; other site 198094007645 Heat induced stress protein YflT; Region: YflT; pfam11181 198094007646 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 198094007647 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 198094007648 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 198094007649 TspO/MBR family; Region: TspO_MBR; pfam03073 198094007650 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 198094007651 DNA photolyase; Region: DNA_photolyase; pfam00875 198094007652 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 198094007653 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 198094007654 zinc binding site [ion binding]; other site 198094007655 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; cl19828 198094007656 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 198094007657 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198094007658 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 198094007659 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198094007660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007661 Coenzyme A binding pocket [chemical binding]; other site 198094007662 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 198094007663 putative active site [active] 198094007664 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094007665 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094007666 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 198094007667 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 198094007668 metal binding site [ion binding]; metal-binding site 198094007669 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094007670 ABC-ATPase subunit interface; other site 198094007671 dimer interface [polypeptide binding]; other site 198094007672 putative PBP binding regions; other site 198094007673 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 198094007674 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198094007675 DJ-1 family protein; Region: not_thiJ; TIGR01383 198094007676 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 198094007677 conserved cys residue [active] 198094007678 Phosphotransferase enzyme family; Region: APH; pfam01636 198094007679 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094007680 active site 198094007681 ATP binding site [chemical binding]; other site 198094007682 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 198094007683 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198094007684 active site 198094007685 arsenical-resistance protein; Region: acr3; TIGR00832 198094007686 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 198094007687 putative metal binding site [ion binding]; other site 198094007688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094007689 dimerization interface [polypeptide binding]; other site 198094007690 putative DNA binding site [nucleotide binding]; other site 198094007691 putative Zn2+ binding site [ion binding]; other site 198094007692 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 198094007693 DnaJ domain; Region: DnaJ; pfam00226 198094007694 HSP70 interaction site [polypeptide binding]; other site 198094007695 TPR repeat; Region: TPR_11; pfam13414 198094007696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094007697 binding surface 198094007698 TPR motif; other site 198094007699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198094007700 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 198094007701 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 198094007702 nucleotide binding site [chemical binding]; other site 198094007703 putative NEF/HSP70 interaction site [polypeptide binding]; other site 198094007704 SBD interface [polypeptide binding]; other site 198094007705 short chain dehydrogenase; Provisional; Region: PRK12746 198094007706 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 198094007707 NAD(P) binding site [chemical binding]; other site 198094007708 active site 198094007709 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198094007710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094007711 putative DNA binding site [nucleotide binding]; other site 198094007712 putative Zn2+ binding site [ion binding]; other site 198094007713 AsnC family; Region: AsnC_trans_reg; pfam01037 198094007714 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 198094007715 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198094007716 metal binding site [ion binding]; metal-binding site 198094007717 AAA domain; Region: AAA_11; pfam13086 198094007718 Part of AAA domain; Region: AAA_19; pfam13245 198094007719 Erp protein C-terminus; Region: Erp_C; pfam06780 198094007720 AAA domain; Region: AAA_30; pfam13604 198094007721 AAA domain; Region: AAA_12; pfam13087 198094007722 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 198094007723 putative active site [active] 198094007724 catalytic site [active] 198094007725 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 198094007726 active site 198094007727 metal binding site [ion binding]; metal-binding site 198094007728 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 198094007729 putative transporter; Provisional; Region: PRK11021 198094007730 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094007731 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094007732 putative monooxygenase; Provisional; Region: PRK11118 198094007733 DoxX-like family; Region: DoxX_2; pfam13564 198094007734 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094007735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 198094007736 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 198094007737 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 198094007738 Flavodoxin; Region: Flavodoxin_1; pfam00258 198094007739 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 198094007740 FAD binding pocket [chemical binding]; other site 198094007741 FAD binding motif [chemical binding]; other site 198094007742 catalytic residues [active] 198094007743 NAD binding pocket [chemical binding]; other site 198094007744 phosphate binding motif [ion binding]; other site 198094007745 beta-alpha-beta structure motif; other site 198094007746 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198094007747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007748 putative substrate translocation pore; other site 198094007749 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 198094007750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094007751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094007752 active site 198094007753 phosphorylation site [posttranslational modification] 198094007754 intermolecular recognition site; other site 198094007755 dimerization interface [polypeptide binding]; other site 198094007756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094007757 DNA binding site [nucleotide binding] 198094007758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094007759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094007760 dimerization interface [polypeptide binding]; other site 198094007761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094007762 dimer interface [polypeptide binding]; other site 198094007763 phosphorylation site [posttranslational modification] 198094007764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094007765 ATP binding site [chemical binding]; other site 198094007766 Mg2+ binding site [ion binding]; other site 198094007767 G-X-G motif; other site 198094007768 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 198094007769 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198094007770 D-cysteine desulfhydrase; Validated; Region: PRK03910 198094007771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094007772 catalytic residue [active] 198094007773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094007774 salt bridge; other site 198094007775 non-specific DNA binding site [nucleotide binding]; other site 198094007776 sequence-specific DNA binding site [nucleotide binding]; other site 198094007777 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 198094007778 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198094007779 active site 198094007780 CoA binding site [chemical binding]; other site 198094007781 AMP binding site [chemical binding]; other site 198094007782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 198094007783 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198094007784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094007785 NAD(P) binding site [chemical binding]; other site 198094007786 active site 198094007787 hypothetical protein; Provisional; Region: PRK06849 198094007788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094007789 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198094007790 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 198094007791 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 198094007792 dimer interface [polypeptide binding]; other site 198094007793 active site 198094007794 CoA binding pocket [chemical binding]; other site 198094007795 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 198094007796 AAA domain; Region: AAA_33; pfam13671 198094007797 AAA domain; Region: AAA_18; pfam13238 198094007798 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 198094007799 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 198094007800 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094007801 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094007802 Walker A/P-loop; other site 198094007803 ATP binding site [chemical binding]; other site 198094007804 Q-loop/lid; other site 198094007805 ABC transporter signature motif; other site 198094007806 Walker B; other site 198094007807 D-loop; other site 198094007808 H-loop/switch region; other site 198094007809 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198094007810 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094007811 FtsX-like permease family; Region: FtsX; pfam02687 198094007812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094007813 dimerization interface [polypeptide binding]; other site 198094007814 putative DNA binding site [nucleotide binding]; other site 198094007815 Predicted transcriptional regulator [Transcription]; Region: COG2345 198094007816 putative Zn2+ binding site [ion binding]; other site 198094007817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007818 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094007819 putative substrate translocation pore; other site 198094007820 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 198094007821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094007822 dimerization interface [polypeptide binding]; other site 198094007823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094007824 dimer interface [polypeptide binding]; other site 198094007825 phosphorylation site [posttranslational modification] 198094007826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094007827 ATP binding site [chemical binding]; other site 198094007828 Mg2+ binding site [ion binding]; other site 198094007829 G-X-G motif; other site 198094007830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094007831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094007832 active site 198094007833 phosphorylation site [posttranslational modification] 198094007834 intermolecular recognition site; other site 198094007835 dimerization interface [polypeptide binding]; other site 198094007836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094007837 DNA binding site [nucleotide binding] 198094007838 Predicted membrane protein [Function unknown]; Region: COG2364 198094007839 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094007840 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094007841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 198094007842 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 198094007843 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094007844 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094007845 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094007846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007847 D-galactonate transporter; Region: 2A0114; TIGR00893 198094007848 putative substrate translocation pore; other site 198094007849 Uncharacterized conserved protein [Function unknown]; Region: COG1556 198094007850 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 198094007851 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 198094007852 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198094007853 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 198094007854 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 198094007855 Cysteine-rich domain; Region: CCG; pfam02754 198094007856 Cysteine-rich domain; Region: CCG; pfam02754 198094007857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094007858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094007859 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198094007860 dimerization interface [polypeptide binding]; other site 198094007861 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 198094007862 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 198094007863 putative dimer interface [polypeptide binding]; other site 198094007864 catalytic triad [active] 198094007865 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 198094007866 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 198094007867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007868 putative substrate translocation pore; other site 198094007869 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198094007870 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198094007871 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198094007872 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 198094007873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094007874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094007875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094007876 DNA binding site [nucleotide binding] 198094007877 domain linker motif; other site 198094007878 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 198094007879 putative dimerization interface [polypeptide binding]; other site 198094007880 putative ligand binding site [chemical binding]; other site 198094007881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094007882 TPR motif; other site 198094007883 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198094007884 binding surface 198094007885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094007886 TPR motif; other site 198094007887 binding surface 198094007888 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 198094007889 PKC phosphorylation site [posttranslational modification]; other site 198094007890 DNA polymerase IV; Reviewed; Region: PRK03103 198094007891 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 198094007892 active site 198094007893 DNA binding site [nucleotide binding] 198094007894 YolD-like protein; Region: YolD; pfam08863 198094007895 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198094007896 Cache domain; Region: Cache_1; pfam02743 198094007897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094007898 dimerization interface [polypeptide binding]; other site 198094007899 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094007900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198094007901 dimer interface [polypeptide binding]; other site 198094007902 putative CheW interface [polypeptide binding]; other site 198094007903 CAAX protease self-immunity; Region: Abi; pfam02517 198094007904 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094007905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094007906 Coenzyme A binding pocket [chemical binding]; other site 198094007907 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 198094007908 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 198094007909 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 198094007910 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 198094007911 FOG: PKD repeat [General function prediction only]; Region: COG3291 198094007912 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 198094007913 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 198094007914 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198094007915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007916 putative substrate translocation pore; other site 198094007917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094007918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094007919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094007920 dimerization interface [polypeptide binding]; other site 198094007921 putative DNA binding site [nucleotide binding]; other site 198094007922 putative Zn2+ binding site [ion binding]; other site 198094007923 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198094007924 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 198094007925 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 198094007926 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 198094007927 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198094007928 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094007929 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198094007930 inhibitor-cofactor binding pocket; inhibition site 198094007931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094007932 catalytic residue [active] 198094007933 Acylphosphatase; Region: Acylphosphatase; pfam00708 198094007934 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 198094007935 HypF finger; Region: zf-HYPF; pfam07503 198094007936 HypF finger; Region: zf-HYPF; pfam07503 198094007937 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 198094007938 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 198094007939 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 198094007940 dimerization interface [polypeptide binding]; other site 198094007941 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 198094007942 ATP binding site [chemical binding]; other site 198094007943 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 198094007944 catalytic triad [active] 198094007945 conserved cis-peptide bond; other site 198094007946 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198094007947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094007948 putative DNA binding site [nucleotide binding]; other site 198094007949 putative Zn2+ binding site [ion binding]; other site 198094007950 AsnC family; Region: AsnC_trans_reg; pfam01037 198094007951 putative transporter; Provisional; Region: PRK11021 198094007952 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094007953 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 198094007954 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 198094007955 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 198094007956 putative ligand binding site [chemical binding]; other site 198094007957 putative NAD binding site [chemical binding]; other site 198094007958 putative catalytic site [active] 198094007959 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 198094007960 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 198094007961 homodimer interface [polypeptide binding]; other site 198094007962 substrate-cofactor binding pocket; other site 198094007963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094007964 catalytic residue [active] 198094007965 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 198094007966 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 198094007967 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 198094007968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094007969 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 198094007970 DNA binding residues [nucleotide binding] 198094007971 Domain of unknown function (DUF378); Region: DUF378; cl00943 198094007972 Cupin domain; Region: Cupin_2; cl17218 198094007973 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198094007974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094007975 Penicillin amidase; Region: Penicil_amidase; pfam01804 198094007976 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 198094007977 active site 198094007978 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 198094007979 A new structural DNA glycosylase; Region: AlkD_like; cd06561 198094007980 active site 198094007981 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 198094007982 S-layer homology domain; Region: SLH; pfam00395 198094007983 S-layer homology domain; Region: SLH; pfam00395 198094007984 S-layer homology domain; Region: SLH; pfam00395 198094007985 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 198094007986 putative metal binding site [ion binding]; other site 198094007987 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 198094007988 NETI protein; Region: NETI; pfam14044 198094007989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094007991 putative substrate translocation pore; other site 198094007992 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094007993 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094007994 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094007995 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094007996 putative DNA binding site [nucleotide binding]; other site 198094007997 putative Zn2+ binding site [ion binding]; other site 198094007998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094007999 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094008000 putative substrate translocation pore; other site 198094008001 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 198094008002 Acyltransferase family; Region: Acyl_transf_3; cl19154 198094008003 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094008004 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094008005 Walker A/P-loop; other site 198094008006 ATP binding site [chemical binding]; other site 198094008007 Q-loop/lid; other site 198094008008 ABC transporter signature motif; other site 198094008009 Walker B; other site 198094008010 D-loop; other site 198094008011 H-loop/switch region; other site 198094008012 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 198094008013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094008014 putative DNA binding site [nucleotide binding]; other site 198094008015 putative Zn2+ binding site [ion binding]; other site 198094008016 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 198094008017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094008018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094008019 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 198094008020 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 198094008021 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 198094008022 SWIM zinc finger; Region: SWIM; pfam04434 198094008023 YwiC-like protein; Region: YwiC; pfam14256 198094008024 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 198094008025 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198094008026 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198094008027 Walker A/P-loop; other site 198094008028 ATP binding site [chemical binding]; other site 198094008029 Q-loop/lid; other site 198094008030 ABC transporter signature motif; other site 198094008031 Walker B; other site 198094008032 D-loop; other site 198094008033 H-loop/switch region; other site 198094008034 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198094008035 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 198094008036 Walker A/P-loop; other site 198094008037 ATP binding site [chemical binding]; other site 198094008038 Q-loop/lid; other site 198094008039 ABC transporter signature motif; other site 198094008040 Walker B; other site 198094008041 D-loop; other site 198094008042 H-loop/switch region; other site 198094008043 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 198094008044 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 198094008045 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 198094008046 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 198094008047 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 198094008048 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 198094008049 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 198094008050 Predicted membrane protein [Function unknown]; Region: COG1288 198094008051 Endonuclease I; Region: Endonuclease_1; pfam04231 198094008052 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094008053 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 198094008054 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094008055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094008056 non-specific DNA binding site [nucleotide binding]; other site 198094008057 salt bridge; other site 198094008058 sequence-specific DNA binding site [nucleotide binding]; other site 198094008059 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 198094008060 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 198094008061 putative deacylase active site [active] 198094008062 histidyl-tRNA synthetase; Provisional; Region: PRK12420 198094008063 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 198094008064 dimer interface [polypeptide binding]; other site 198094008065 motif 1; other site 198094008066 active site 198094008067 motif 2; other site 198094008068 motif 3; other site 198094008069 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 198094008070 anticodon binding site; other site 198094008071 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 198094008072 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 198094008073 dimer interface [polypeptide binding]; other site 198094008074 FMN binding site [chemical binding]; other site 198094008075 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 198094008076 pyruvate kinase; Validated; Region: PRK06739 198094008077 protein kinase; Provisional; Region: PTZ00284 198094008078 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 198094008079 classical (c) SDRs; Region: SDR_c; cd05233 198094008080 NAD(P) binding site [chemical binding]; other site 198094008081 active site 198094008082 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 198094008083 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094008084 Walker A/P-loop; other site 198094008085 ATP binding site [chemical binding]; other site 198094008086 Q-loop/lid; other site 198094008087 ABC transporter signature motif; other site 198094008088 Walker B; other site 198094008089 D-loop; other site 198094008090 H-loop/switch region; other site 198094008091 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 198094008092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094008093 non-specific DNA binding site [nucleotide binding]; other site 198094008094 salt bridge; other site 198094008095 sequence-specific DNA binding site [nucleotide binding]; other site 198094008096 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 198094008097 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 198094008098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094008099 motif II; other site 198094008100 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 198094008101 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 198094008102 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 198094008103 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 198094008104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094008105 Coenzyme A binding pocket [chemical binding]; other site 198094008106 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 198094008107 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 198094008108 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 198094008109 putative metal binding site [ion binding]; other site 198094008110 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198094008111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198094008112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094008113 putative substrate translocation pore; other site 198094008114 D-galactonate transporter; Region: 2A0114; TIGR00893 198094008115 maltose O-acetyltransferase; Provisional; Region: PRK10092 198094008116 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 198094008117 active site 198094008118 substrate binding site [chemical binding]; other site 198094008119 trimer interface [polypeptide binding]; other site 198094008120 CoA binding site [chemical binding]; other site 198094008121 FtsX-like permease family; Region: FtsX; pfam02687 198094008122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198094008123 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 198094008124 FtsX-like permease family; Region: FtsX; pfam02687 198094008125 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094008126 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094008127 Walker A/P-loop; other site 198094008128 ATP binding site [chemical binding]; other site 198094008129 Q-loop/lid; other site 198094008130 ABC transporter signature motif; other site 198094008131 Walker B; other site 198094008132 D-loop; other site 198094008133 H-loop/switch region; other site 198094008134 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 198094008135 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 198094008136 active site 198094008137 HIGH motif; other site 198094008138 dimer interface [polypeptide binding]; other site 198094008139 KMSKS motif; other site 198094008140 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 198094008141 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 198094008142 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 198094008143 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 198094008144 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 198094008145 Predicted membrane protein [Function unknown]; Region: COG2261 198094008146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094008147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094008148 Coenzyme A binding pocket [chemical binding]; other site 198094008149 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 198094008150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094008151 S-adenosylmethionine binding site [chemical binding]; other site 198094008152 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198094008153 CGNR zinc finger; Region: zf-CGNR; pfam11706 198094008154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094008155 multidrug resistance protein MdtH; Provisional; Region: PRK11646 198094008156 putative substrate translocation pore; other site 198094008157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094008158 TPR motif; other site 198094008159 TPR repeat; Region: TPR_11; pfam13414 198094008160 binding surface 198094008161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094008162 binding surface 198094008163 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 198094008164 TPR motif; other site 198094008165 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 198094008166 hypothetical protein; Provisional; Region: PRK04164 198094008167 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 198094008168 ATP synthase I chain; Region: ATP_synt_I; pfam03899 198094008169 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 198094008170 Domain of unknown function DUF21; Region: DUF21; pfam01595 198094008171 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198094008172 Transporter associated domain; Region: CorC_HlyC; smart01091 198094008173 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 198094008174 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094008175 DNA binding residues [nucleotide binding] 198094008176 putative dimer interface [polypeptide binding]; other site 198094008177 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094008178 EamA-like transporter family; Region: EamA; pfam00892 198094008179 EamA-like transporter family; Region: EamA; pfam00892 198094008180 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 198094008181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 198094008182 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 198094008183 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 198094008184 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 198094008185 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 198094008186 N- and C-terminal domain interface [polypeptide binding]; other site 198094008187 active site 198094008188 catalytic site [active] 198094008189 metal binding site [ion binding]; metal-binding site 198094008190 carbohydrate binding site [chemical binding]; other site 198094008191 ATP binding site [chemical binding]; other site 198094008192 GntP family permease; Region: GntP_permease; pfam02447 198094008193 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 198094008194 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 198094008195 active site 198094008196 intersubunit interactions; other site 198094008197 catalytic residue [active] 198094008198 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 198094008199 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 198094008200 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 198094008201 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 198094008202 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198094008203 TPP-binding site [chemical binding]; other site 198094008204 dimer interface [polypeptide binding]; other site 198094008205 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198094008206 PYR/PP interface [polypeptide binding]; other site 198094008207 dimer interface [polypeptide binding]; other site 198094008208 TPP binding site [chemical binding]; other site 198094008209 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198094008210 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 198094008211 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 198094008212 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 198094008213 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 198094008214 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198094008215 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 198094008216 putative NAD(P) binding site [chemical binding]; other site 198094008217 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 198094008218 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 198094008219 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198094008220 putative NAD(P) binding site [chemical binding]; other site 198094008221 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 198094008222 classical (c) SDRs; Region: SDR_c; cd05233 198094008223 NAD(P) binding site [chemical binding]; other site 198094008224 active site 198094008225 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 198094008226 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 198094008227 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 198094008228 active site 198094008229 Zn binding site [ion binding]; other site 198094008230 Peptidase M60-like family; Region: M60-like; cl19940 198094008231 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 198094008232 dimer interface [polypeptide binding]; other site 198094008233 FMN binding site [chemical binding]; other site 198094008234 BNR repeat-like domain; Region: BNR_2; pfam13088 198094008235 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094008236 active site 198094008237 catalytic tetrad [active] 198094008238 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198094008239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094008240 putative substrate translocation pore; other site 198094008241 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 198094008242 active site 1 [active] 198094008243 dimer interface [polypeptide binding]; other site 198094008244 hexamer interface [polypeptide binding]; other site 198094008245 active site 2 [active] 198094008246 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 198094008247 hexamer interface [polypeptide binding]; other site 198094008248 active site 2 [active] 198094008249 hypothetical protein; Provisional; Region: PRK02487 198094008250 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 198094008251 active site 198094008252 metal binding site [ion binding]; metal-binding site 198094008253 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198094008254 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 198094008255 IDEAL domain; Region: IDEAL; pfam08858 198094008256 Predicted transcriptional regulator [Transcription]; Region: COG1959 198094008257 Rrf2 family protein; Region: rrf2_super; TIGR00738 198094008258 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 198094008259 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 198094008260 putative catalytic residues [active] 198094008261 thiol/disulfide switch; other site 198094008262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094008263 dimerization interface [polypeptide binding]; other site 198094008264 putative DNA binding site [nucleotide binding]; other site 198094008265 putative Zn2+ binding site [ion binding]; other site 198094008266 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198094008267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094008268 DNA-binding site [nucleotide binding]; DNA binding site 198094008269 UTRA domain; Region: UTRA; pfam07702 198094008270 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 198094008271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094008272 S-adenosylmethionine binding site [chemical binding]; other site 198094008273 Predicted transcriptional regulators [Transcription]; Region: COG1733 198094008274 dimerization interface [polypeptide binding]; other site 198094008275 putative DNA binding site [nucleotide binding]; other site 198094008276 putative Zn2+ binding site [ion binding]; other site 198094008277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094008278 dimerization interface [polypeptide binding]; other site 198094008279 putative DNA binding site [nucleotide binding]; other site 198094008280 putative Zn2+ binding site [ion binding]; other site 198094008281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094008282 active site 198094008283 catalytic tetrad [active] 198094008284 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 198094008285 putative hydrophobic ligand binding site [chemical binding]; other site 198094008286 protein interface [polypeptide binding]; other site 198094008287 gate; other site 198094008288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094008289 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094008290 active site 198094008291 substrate binding site [chemical binding]; other site 198094008292 ATP binding site [chemical binding]; other site 198094008293 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 198094008294 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 198094008295 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094008296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094008297 Coenzyme A binding pocket [chemical binding]; other site 198094008298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094008299 short chain dehydrogenase; Region: adh_short; pfam00106 198094008300 NAD(P) binding site [chemical binding]; other site 198094008301 active site 198094008302 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094008303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094008304 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 198094008305 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198094008306 acyl-activating enzyme (AAE) consensus motif; other site 198094008307 AMP binding site [chemical binding]; other site 198094008308 active site 198094008309 CoA binding site [chemical binding]; other site 198094008310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094008311 dimerization interface [polypeptide binding]; other site 198094008312 putative DNA binding site [nucleotide binding]; other site 198094008313 putative Zn2+ binding site [ion binding]; other site 198094008314 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 198094008315 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198094008316 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198094008317 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198094008318 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198094008319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094008320 dimerization interface [polypeptide binding]; other site 198094008321 putative DNA binding site [nucleotide binding]; other site 198094008322 putative Zn2+ binding site [ion binding]; other site 198094008323 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 198094008324 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 198094008325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094008326 CAAX protease self-immunity; Region: Abi; pfam02517 198094008327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094008328 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094008329 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 198094008330 Integron-associated effector binding protein; Region: Cass2; pfam14526 198094008331 Protein of unknown function (DUF805); Region: DUF805; pfam05656 198094008332 ABC-2 type transporter; Region: ABC2_membrane; cl17235 198094008333 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198094008334 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 198094008335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094008336 Walker A/P-loop; other site 198094008337 ATP binding site [chemical binding]; other site 198094008338 Q-loop/lid; other site 198094008339 ABC transporter signature motif; other site 198094008340 Walker B; other site 198094008341 D-loop; other site 198094008342 H-loop/switch region; other site 198094008343 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 198094008344 Predicted transcriptional regulators [Transcription]; Region: COG1695 198094008345 hydroxylamine reductase; Provisional; Region: PRK12310 198094008346 ACS interaction site; other site 198094008347 CODH interaction site; other site 198094008348 metal cluster binding site [ion binding]; other site 198094008349 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 198094008350 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094008351 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 198094008352 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 198094008353 active site 198094008354 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 198094008355 metal binding site [ion binding]; metal-binding site 198094008356 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 198094008357 hypothetical protein; Provisional; Region: PRK06771 198094008358 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094008359 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 198094008360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 198094008361 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 198094008362 dimer interface [polypeptide binding]; other site 198094008363 ligand binding site [chemical binding]; other site 198094008364 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 198094008365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198094008366 ligand binding site [chemical binding]; other site 198094008367 flexible hinge region; other site 198094008368 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 198094008369 Protein of unknown function, DUF606; Region: DUF606; pfam04657 198094008370 Protein of unknown function, DUF606; Region: DUF606; pfam04657 198094008371 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094008372 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 198094008373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094008374 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 198094008375 putative substrate translocation pore; other site 198094008376 Haemolysin XhlA; Region: XhlA; pfam10779 198094008377 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 198094008378 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 198094008379 Citrate transporter; Region: CitMHS; pfam03600 198094008380 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 198094008381 transmembrane helices; other site 198094008382 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094008383 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094008384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094008385 Coenzyme A binding pocket [chemical binding]; other site 198094008386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094008387 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 198094008388 putative ligand binding residues [chemical binding]; other site 198094008389 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198094008390 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094008391 ABC-ATPase subunit interface; other site 198094008392 dimer interface [polypeptide binding]; other site 198094008393 putative PBP binding regions; other site 198094008394 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094008395 ABC-ATPase subunit interface; other site 198094008396 dimer interface [polypeptide binding]; other site 198094008397 putative PBP binding regions; other site 198094008398 Protein of unknown function (DUF817); Region: DUF817; pfam05675 198094008399 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 198094008400 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 198094008401 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 198094008402 DinB superfamily; Region: DinB_2; pfam12867 198094008403 DinB family; Region: DinB; cl17821 198094008404 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 198094008405 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 198094008406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094008407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094008408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198094008409 dimerization interface [polypeptide binding]; other site 198094008410 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198094008411 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 198094008412 NADP binding site [chemical binding]; other site 198094008413 dimer interface [polypeptide binding]; other site 198094008414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198094008415 catalytic core [active] 198094008416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094008417 Coenzyme A binding pocket [chemical binding]; other site 198094008418 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 198094008419 MutS domain III; Region: MutS_III; pfam05192 198094008420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094008421 Walker A/P-loop; other site 198094008422 ATP binding site [chemical binding]; other site 198094008423 Q-loop/lid; other site 198094008424 ABC transporter signature motif; other site 198094008425 Walker B; other site 198094008426 D-loop; other site 198094008427 H-loop/switch region; other site 198094008428 exosporium leader peptide; Region: exospor_lead; TIGR03720 198094008429 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 198094008430 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 198094008431 active site 198094008432 Na/Ca binding site [ion binding]; other site 198094008433 catalytic site [active] 198094008434 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 198094008435 oligoendopeptidase F; Region: pepF; TIGR00181 198094008436 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 198094008437 active site 198094008438 Zn binding site [ion binding]; other site 198094008439 Beta-lactamase; Region: Beta-lactamase; pfam00144 198094008440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094008441 putative substrate translocation pore; other site 198094008442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094008443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094008444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094008445 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 198094008446 putative dimerization interface [polypeptide binding]; other site 198094008447 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 198094008448 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198094008449 putative active site [active] 198094008450 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 198094008451 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 198094008452 active site 198094008453 catalytic site [active] 198094008454 metal binding site [ion binding]; metal-binding site 198094008455 hypothetical protein; Provisional; Region: PRK06126 198094008456 FAD binding domain; Region: FAD_binding_3; pfam01494 198094008457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094008458 dimerization interface [polypeptide binding]; other site 198094008459 putative DNA binding site [nucleotide binding]; other site 198094008460 putative Zn2+ binding site [ion binding]; other site 198094008461 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198094008462 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 198094008463 putative NAD(P) binding site [chemical binding]; other site 198094008464 hypothetical protein; Validated; Region: PRK00029 198094008465 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 198094008466 GrpB protein; Region: GrpB; pfam04229 198094008467 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 198094008468 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 198094008469 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 198094008470 FAD binding domain; Region: FAD_binding_4; pfam01565 198094008471 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 198094008472 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 198094008473 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 198094008474 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 198094008475 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 198094008476 trimer interface [polypeptide binding]; other site 198094008477 active site 198094008478 substrate binding site [chemical binding]; other site 198094008479 CoA binding site [chemical binding]; other site 198094008480 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 198094008481 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094008482 catalytic residue [active] 198094008483 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 198094008484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094008485 active site 198094008486 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198094008487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094008488 active site 198094008489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094008490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 198094008491 enoyl-CoA hydratase; Provisional; Region: PRK06688 198094008492 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198094008493 substrate binding site [chemical binding]; other site 198094008494 oxyanion hole (OAH) forming residues; other site 198094008495 trimer interface [polypeptide binding]; other site 198094008496 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 198094008497 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 198094008498 FOG: PKD repeat [General function prediction only]; Region: COG3291 198094008499 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 198094008500 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 198094008501 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 198094008502 MgtC family; Region: MgtC; pfam02308 198094008503 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094008504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094008505 Coenzyme A binding pocket [chemical binding]; other site 198094008506 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 198094008507 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 198094008508 putative metal binding site [ion binding]; other site 198094008509 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 198094008510 active site 198094008511 metal binding site [ion binding]; metal-binding site 198094008512 VanW like protein; Region: VanW; pfam04294 198094008513 Haemolysin XhlA; Region: XhlA; pfam10779 198094008514 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 198094008515 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 198094008516 exonuclease; Provisional; Region: PRK06722 198094008517 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 198094008518 active site 198094008519 catalytic site [active] 198094008520 substrate binding site [chemical binding]; other site 198094008521 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198094008522 DNA-binding site [nucleotide binding]; DNA binding site 198094008523 RNA-binding motif; other site 198094008524 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 198094008525 flavodoxin; Provisional; Region: PRK06703 198094008526 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 198094008527 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669 198094008528 nudix motif; other site 198094008529 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 198094008530 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 198094008531 trimer interface [polypeptide binding]; other site 198094008532 active site 198094008533 substrate binding site [chemical binding]; other site 198094008534 CoA binding site [chemical binding]; other site 198094008535 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008536 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008537 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008538 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008539 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008540 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008541 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008542 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008543 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008544 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008545 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008546 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008547 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008548 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008549 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008550 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 198094008551 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 198094008552 NADP binding site [chemical binding]; other site 198094008553 homodimer interface [polypeptide binding]; other site 198094008554 active site 198094008555 Predicted acetyltransferase [General function prediction only]; Region: COG3393 198094008556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094008557 argininosuccinate lyase; Provisional; Region: PRK06705 198094008558 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 198094008559 active sites [active] 198094008560 tetramer interface [polypeptide binding]; other site 198094008561 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094008562 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094008563 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 198094008564 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 198094008565 active site 198094008566 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 198094008567 Na binding site [ion binding]; other site 198094008568 Protein of unknown function (DUF997); Region: DUF997; pfam06196 198094008569 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 198094008570 NAD(P) binding site [chemical binding]; other site 198094008571 catalytic residues [active] 198094008572 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 198094008573 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 198094008574 NAD(P) binding site [chemical binding]; other site 198094008575 homotetramer interface [polypeptide binding]; other site 198094008576 homodimer interface [polypeptide binding]; other site 198094008577 active site 198094008578 YfhD-like protein; Region: YfhD; pfam14151 198094008579 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 198094008580 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 198094008581 Divergent PAP2 family; Region: DUF212; pfam02681 198094008582 Predicted permeases [General function prediction only]; Region: RarD; COG2962 198094008583 EamA-like transporter family; Region: EamA; pfam00892 198094008584 EamA-like transporter family; Region: EamA; pfam00892 198094008585 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 198094008586 antiporter inner membrane protein; Provisional; Region: PRK11670 198094008587 Domain of unknown function DUF59; Region: DUF59; pfam01883 198094008588 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 198094008589 Walker A motif; other site 198094008590 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 198094008591 MoaE interaction surface [polypeptide binding]; other site 198094008592 MoeB interaction surface [polypeptide binding]; other site 198094008593 thiocarboxylated glycine; other site 198094008594 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 198094008595 MoaE homodimer interface [polypeptide binding]; other site 198094008596 MoaD interaction [polypeptide binding]; other site 198094008597 active site residues [active] 198094008598 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 198094008599 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 198094008600 dimer interface [polypeptide binding]; other site 198094008601 putative functional site; other site 198094008602 putative MPT binding site; other site 198094008603 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 198094008604 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198094008605 ATP binding site [chemical binding]; other site 198094008606 substrate interface [chemical binding]; other site 198094008607 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 198094008608 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 198094008609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094008610 FeS/SAM binding site; other site 198094008611 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 198094008612 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 198094008613 Uncharacterized conserved protein [Function unknown]; Region: COG5609 198094008614 Uncharacterized conserved protein [Function unknown]; Region: COG2427 198094008615 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 198094008616 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198094008617 catalytic loop [active] 198094008618 iron binding site [ion binding]; other site 198094008619 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 198094008620 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198094008621 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 198094008622 [4Fe-4S] binding site [ion binding]; other site 198094008623 molybdopterin cofactor binding site; other site 198094008624 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 198094008625 molybdopterin cofactor binding site; other site 198094008626 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 198094008627 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 198094008628 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 198094008629 Tubulin like; Region: Tubulin_2; pfam13809 198094008630 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 198094008631 metal ion-dependent adhesion site (MIDAS); other site 198094008632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094008633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094008634 S-adenosylmethionine binding site [chemical binding]; other site 198094008635 O-methyltransferase; Region: Methyltransf_2; pfam00891 198094008636 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094008637 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094008638 peptide binding site [polypeptide binding]; other site 198094008639 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094008640 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094008641 peptide binding site [polypeptide binding]; other site 198094008642 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198094008643 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198094008644 peptide binding site [polypeptide binding]; other site 198094008645 Transcriptional regulator [Transcription]; Region: LytR; COG1316 198094008646 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 198094008647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094008648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094008649 DNA binding residues [nucleotide binding] 198094008650 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 198094008651 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094008652 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094008653 Walker A/P-loop; other site 198094008654 ATP binding site [chemical binding]; other site 198094008655 Q-loop/lid; other site 198094008656 ABC transporter signature motif; other site 198094008657 Walker B; other site 198094008658 D-loop; other site 198094008659 H-loop/switch region; other site 198094008660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094008661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094008662 putative oxidoreductase; Provisional; Region: PRK11579 198094008663 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198094008664 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198094008665 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 198094008666 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 198094008667 CAP-like domain; other site 198094008668 active site 198094008669 primary dimer interface [polypeptide binding]; other site 198094008670 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094008671 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094008672 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094008673 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198094008674 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 198094008675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094008676 ATP binding site [chemical binding]; other site 198094008677 Mg2+ binding site [ion binding]; other site 198094008678 G-X-G motif; other site 198094008679 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 198094008680 anchoring element; other site 198094008681 dimer interface [polypeptide binding]; other site 198094008682 ATP binding site [chemical binding]; other site 198094008683 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 198094008684 active site 198094008685 metal binding site [ion binding]; metal-binding site 198094008686 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 198094008687 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 198094008688 Trypsin; Region: Trypsin; pfam00089 198094008689 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198094008690 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198094008691 protein binding site [polypeptide binding]; other site 198094008692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094008693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094008694 active site 198094008695 phosphorylation site [posttranslational modification] 198094008696 intermolecular recognition site; other site 198094008697 dimerization interface [polypeptide binding]; other site 198094008698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094008699 DNA binding site [nucleotide binding] 198094008700 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 198094008701 Class III ribonucleotide reductase; Region: RNR_III; cd01675 198094008702 effector binding site; other site 198094008703 active site 198094008704 Zn binding site [ion binding]; other site 198094008705 glycine loop; other site 198094008706 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 198094008707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 198094008708 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 198094008709 active site 198094008710 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 198094008711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198094008712 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198094008713 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 198094008714 active site 198094008715 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 198094008716 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 198094008717 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 198094008718 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 198094008719 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 198094008720 active site 198094008721 catalytic site [active] 198094008722 substrate binding site [chemical binding]; other site 198094008723 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 198094008724 catalytic residues [active] 198094008725 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 198094008726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094008727 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198094008728 Walker A/P-loop; other site 198094008729 ATP binding site [chemical binding]; other site 198094008730 ABC transporter signature motif; other site 198094008731 Walker B; other site 198094008732 D-loop; other site 198094008733 H-loop/switch region; other site 198094008734 aconitate hydratase; Validated; Region: PRK09277 198094008735 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 198094008736 substrate binding site [chemical binding]; other site 198094008737 ligand binding site [chemical binding]; other site 198094008738 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 198094008739 substrate binding site [chemical binding]; other site 198094008740 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 198094008741 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 198094008742 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 198094008743 NodB motif; other site 198094008744 active site 198094008745 catalytic site [active] 198094008746 metal binding site [ion binding]; metal-binding site 198094008747 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198094008748 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 198094008749 putative dimer interface [polypeptide binding]; other site 198094008750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094008751 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 198094008752 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 198094008753 DHHA1 domain; Region: DHHA1; pfam02272 198094008754 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 198094008755 nudix motif; other site 198094008756 SAP domain; Region: SAP; pfam02037 198094008757 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 198094008758 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198094008759 dimer interface [polypeptide binding]; other site 198094008760 active site 198094008761 acyl-CoA synthetase; Validated; Region: PRK07638 198094008762 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198094008763 acyl-activating enzyme (AAE) consensus motif; other site 198094008764 AMP binding site [chemical binding]; other site 198094008765 active site 198094008766 CoA binding site [chemical binding]; other site 198094008767 BioY family; Region: BioY; pfam02632 198094008768 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 198094008769 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 198094008770 dimer interface [polypeptide binding]; other site 198094008771 acyl-activating enzyme (AAE) consensus motif; other site 198094008772 putative active site [active] 198094008773 AMP binding site [chemical binding]; other site 198094008774 putative CoA binding site [chemical binding]; other site 198094008775 CsbD-like; Region: CsbD; pfam05532 198094008776 S-layer homology domain; Region: SLH; pfam00395 198094008777 S-layer homology domain; Region: SLH; pfam00395 198094008778 S-layer homology domain; Region: SLH; pfam00395 198094008779 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198094008780 active site 198094008781 catalytic motif [active] 198094008782 Zn binding site [ion binding]; other site 198094008783 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 198094008784 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198094008785 amidase catalytic site [active] 198094008786 Zn binding residues [ion binding]; other site 198094008787 substrate binding site [chemical binding]; other site 198094008788 active site 198094008789 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 198094008790 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094008791 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094008792 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094008793 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 198094008794 dimer interface [polypeptide binding]; other site 198094008795 putative metal binding site [ion binding]; other site 198094008796 PAS domain S-box; Region: sensory_box; TIGR00229 198094008797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094008798 putative active site [active] 198094008799 heme pocket [chemical binding]; other site 198094008800 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 198094008801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094008802 putative active site [active] 198094008803 heme pocket [chemical binding]; other site 198094008804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094008805 dimer interface [polypeptide binding]; other site 198094008806 phosphorylation site [posttranslational modification] 198094008807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094008808 ATP binding site [chemical binding]; other site 198094008809 Mg2+ binding site [ion binding]; other site 198094008810 G-X-G motif; other site 198094008811 Predicted esterase [General function prediction only]; Region: COG0400 198094008812 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 198094008813 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 198094008814 Zn binding site [ion binding]; other site 198094008815 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 198094008816 Zn binding site [ion binding]; other site 198094008817 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 198094008818 Na binding site [ion binding]; other site 198094008819 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 198094008820 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 198094008821 active site 198094008822 FMN binding site [chemical binding]; other site 198094008823 substrate binding site [chemical binding]; other site 198094008824 3Fe-4S cluster binding site [ion binding]; other site 198094008825 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 198094008826 FMN binding site [chemical binding]; other site 198094008827 active site 198094008828 substrate binding site [chemical binding]; other site 198094008829 catalytic residue [active] 198094008830 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 198094008831 Agmatinase-like family; Region: Agmatinase-like; cd09990 198094008832 active site 198094008833 oligomer interface [polypeptide binding]; other site 198094008834 Mn binding site [ion binding]; other site 198094008835 imidazolonepropionase; Validated; Region: PRK09356 198094008836 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 198094008837 active site 198094008838 urocanate hydratase; Provisional; Region: PRK05414 198094008839 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 198094008840 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 198094008841 active sites [active] 198094008842 tetramer interface [polypeptide binding]; other site 198094008843 anti-terminator HutP; Provisional; Region: hutP; PRK03065 198094008844 hexamer interface [polypeptide binding]; other site 198094008845 RNA binding site [nucleotide binding]; other site 198094008846 Histidine-zinc binding site [chemical binding]; other site 198094008847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094008848 S-adenosylmethionine binding site [chemical binding]; other site 198094008849 DJ-1 family protein; Region: not_thiJ; TIGR01383 198094008850 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 198094008851 conserved cys residue [active] 198094008852 AAA domain; Region: AAA_28; pfam13521 198094008853 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 198094008854 Domain of unknown function DUF11; Region: DUF11; cl17728 198094008855 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008856 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008857 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008858 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008859 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008860 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008861 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 198094008862 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008863 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008864 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008865 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008866 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008867 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008868 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008869 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008870 conserved repeat domain; Region: B_ant_repeat; TIGR01451 198094008871 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 198094008872 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 198094008873 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 198094008874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094008875 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 198094008876 putative dimerization interface [polypeptide binding]; other site 198094008877 putative substrate binding pocket [chemical binding]; other site 198094008878 holin-like protein; Validated; Region: PRK01658 198094008879 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 198094008880 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 198094008881 nudix motif; other site 198094008882 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 198094008883 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198094008884 amidase catalytic site [active] 198094008885 Zn binding residues [ion binding]; other site 198094008886 substrate binding site [chemical binding]; other site 198094008887 S-layer homology domain; Region: SLH; pfam00395 198094008888 S-layer homology domain; Region: SLH; pfam00395 198094008889 S-layer homology domain; Region: SLH; pfam00395 198094008890 Nuclease-related domain; Region: NERD; pfam08378 198094008891 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 198094008892 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094008893 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 198094008894 Walker A/P-loop; other site 198094008895 ATP binding site [chemical binding]; other site 198094008896 Q-loop/lid; other site 198094008897 ABC transporter signature motif; other site 198094008898 Walker B; other site 198094008899 D-loop; other site 198094008900 H-loop/switch region; other site 198094008901 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094008902 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 198094008903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094008904 Walker A/P-loop; other site 198094008905 ATP binding site [chemical binding]; other site 198094008906 Q-loop/lid; other site 198094008907 ABC transporter signature motif; other site 198094008908 Walker B; other site 198094008909 D-loop; other site 198094008910 H-loop/switch region; other site 198094008911 hypothetical protein; Provisional; Region: PRK01844 198094008912 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 198094008913 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 198094008914 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198094008915 TPP-binding site [chemical binding]; other site 198094008916 dimer interface [polypeptide binding]; other site 198094008917 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198094008918 PYR/PP interface [polypeptide binding]; other site 198094008919 dimer interface [polypeptide binding]; other site 198094008920 TPP binding site [chemical binding]; other site 198094008921 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198094008922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 198094008923 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 198094008924 Probable transposase; Region: OrfB_IS605; pfam01385 198094008925 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 198094008926 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 198094008927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094008928 dimer interface [polypeptide binding]; other site 198094008929 conserved gate region; other site 198094008930 putative PBP binding loops; other site 198094008931 ABC-ATPase subunit interface; other site 198094008932 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 198094008933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094008934 dimer interface [polypeptide binding]; other site 198094008935 conserved gate region; other site 198094008936 putative PBP binding loops; other site 198094008937 ABC-ATPase subunit interface; other site 198094008938 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 198094008939 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 198094008940 Walker A/P-loop; other site 198094008941 ATP binding site [chemical binding]; other site 198094008942 Q-loop/lid; other site 198094008943 ABC transporter signature motif; other site 198094008944 Walker B; other site 198094008945 D-loop; other site 198094008946 H-loop/switch region; other site 198094008947 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 198094008948 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 198094008949 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198094008950 membrane-bound complex binding site; other site 198094008951 hypothetical protein; Provisional; Region: PRK01546 198094008952 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 198094008953 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 198094008954 catalytic residues [active] 198094008955 catalytic nucleophile [active] 198094008956 LexA repressor; Validated; Region: PRK00215 198094008957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094008958 putative DNA binding site [nucleotide binding]; other site 198094008959 putative Zn2+ binding site [ion binding]; other site 198094008960 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 198094008961 Catalytic site [active] 198094008962 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 198094008963 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 198094008964 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 198094008965 Predicted transcriptional regulators [Transcription]; Region: COG1695 198094008966 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198094008967 Helix-turn-helix domain; Region: HTH_17; pfam12728 198094008968 Helix-turn-helix domain; Region: HTH_17; pfam12728 198094008969 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198094008970 amidase catalytic site [active] 198094008971 Zn binding residues [ion binding]; other site 198094008972 substrate binding site [chemical binding]; other site 198094008973 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 198094008974 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094008975 Holin family; Region: Phage_holin_4; pfam05105 198094008976 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 198094008977 Phage-related minor tail protein [Function unknown]; Region: COG5280 198094008978 membrane protein P6; Region: PHA01399 198094008979 membrane protein P6; Region: PHA01399 198094008980 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 198094008981 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 198094008982 DsrH like protein; Region: DsrH; cl17347 198094008983 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 198094008984 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 198094008985 uncharacterized phage protein (possible DNA packaging); Region: put_DNA_pack; TIGR01560 198094008986 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 198094008987 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 198094008988 Phage capsid family; Region: Phage_capsid; pfam05065 198094008989 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 198094008990 Phage portal protein; Region: Phage_portal; cl19194 198094008991 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 198094008992 Phage Terminase; Region: Terminase_1; cl19862 198094008993 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198094008994 active site 198094008995 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 198094008996 Helix-turn-helix domain; Region: HTH_17; pfam12728 198094008997 YtxH-like protein; Region: YtxH; cl02079 198094008998 WAX2 C-terminal domain; Region: Wax2_C; pfam12076 198094008999 HNH endonuclease; Region: HNH_2; pfam13391 198094009000 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 198094009001 homodimer interface [polypeptide binding]; other site 198094009002 chemical substrate binding site [chemical binding]; other site 198094009003 oligomer interface [polypeptide binding]; other site 198094009004 metal binding site [ion binding]; metal-binding site 198094009005 HB1, ASXL, restriction endonuclease HTH domain; Region: HARE-HTH; cl01319 198094009006 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198094009007 active site 198094009008 AIPR protein; Region: AIPR; pfam10592 198094009009 positive control sigma-like factor; Validated; Region: PRK06930 198094009010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094009011 DNA binding residues [nucleotide binding] 198094009012 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 198094009013 Lecithin:cholesterol acyltransferase; Region: LCAT; pfam02450 198094009014 PGAP1-like protein; Region: PGAP1; pfam07819 198094009015 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 198094009016 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 198094009017 thymidylate synthase, flavin-dependent; Region: thyX; TIGR02170 198094009018 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 198094009019 cofactor binding site; other site 198094009020 DNA binding site [nucleotide binding] 198094009021 substrate interaction site [chemical binding]; other site 198094009022 dUTPase; Region: dUTPase_2; pfam08761 198094009023 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 198094009024 active site 198094009025 homodimer interface [polypeptide binding]; other site 198094009026 metal binding site [ion binding]; metal-binding site 198094009027 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 198094009028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094009029 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198094009030 Walker A motif; other site 198094009031 ATP binding site [chemical binding]; other site 198094009032 Walker B motif; other site 198094009033 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 198094009034 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 198094009035 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 198094009036 Domain of unknown function (DUF771); Region: DUF771; pfam05595 198094009037 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 198094009038 ORF6C domain; Region: ORF6C; pfam10552 198094009039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009040 non-specific DNA binding site [nucleotide binding]; other site 198094009041 salt bridge; other site 198094009042 sequence-specific DNA binding site [nucleotide binding]; other site 198094009043 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094009044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009045 non-specific DNA binding site [nucleotide binding]; other site 198094009046 salt bridge; other site 198094009047 sequence-specific DNA binding site [nucleotide binding]; other site 198094009048 Domain of unknown function (DUF955); Region: DUF955; cl01076 198094009049 glutamine synthetase, type I; Region: GlnA; TIGR00653 198094009050 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 198094009051 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 198094009052 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 198094009053 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094009054 DNA binding residues [nucleotide binding] 198094009055 putative dimer interface [polypeptide binding]; other site 198094009056 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 198094009057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094009058 catalytic residue [active] 198094009059 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 198094009060 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 198094009061 HflX GTPase family; Region: HflX; cd01878 198094009062 G1 box; other site 198094009063 GTP/Mg2+ binding site [chemical binding]; other site 198094009064 Switch I region; other site 198094009065 G2 box; other site 198094009066 G3 box; other site 198094009067 Switch II region; other site 198094009068 G4 box; other site 198094009069 G5 box; other site 198094009070 Predicted membrane protein [Function unknown]; Region: COG2860 198094009071 UPF0126 domain; Region: UPF0126; pfam03458 198094009072 UPF0126 domain; Region: UPF0126; pfam03458 198094009073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094009074 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198094009075 Walker A motif; other site 198094009076 ATP binding site [chemical binding]; other site 198094009077 Walker B motif; other site 198094009078 arginine finger; other site 198094009079 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 198094009080 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 198094009081 active site 198094009082 catalytic residues [active] 198094009083 DNA binding site [nucleotide binding] 198094009084 Int/Topo IB signature motif; other site 198094009085 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198094009086 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 198094009087 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 198094009088 bacterial Hfq-like; Region: Hfq; cd01716 198094009089 hexamer interface [polypeptide binding]; other site 198094009090 Sm1 motif; other site 198094009091 RNA binding site [nucleotide binding]; other site 198094009092 Sm2 motif; other site 198094009093 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 198094009094 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094009095 Bacterial SH3 domain homologues; Region: SH3b; smart00287 198094009096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 198094009097 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 198094009098 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198094009099 active site 198094009100 phosphorylation site [posttranslational modification] 198094009101 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198094009102 active site 198094009103 P-loop; other site 198094009104 phosphorylation site [posttranslational modification] 198094009105 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 198094009106 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 198094009107 putative substrate binding site [chemical binding]; other site 198094009108 putative ATP binding site [chemical binding]; other site 198094009109 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198094009110 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198094009111 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198094009112 Predicted membrane protein [Function unknown]; Region: COG2322 198094009113 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 198094009114 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 198094009115 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 198094009116 Glyco_18 domain; Region: Glyco_18; smart00636 198094009117 putative active site [active] 198094009118 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 198094009119 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 198094009120 putative active site [active] 198094009121 putative metal binding site [ion binding]; other site 198094009122 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 198094009123 histone-like DNA-binding protein HU; Region: HU; cd13831 198094009124 dimer interface [polypeptide binding]; other site 198094009125 DNA binding site [nucleotide binding] 198094009126 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198094009127 metal-binding site [ion binding] 198094009128 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 198094009129 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198094009130 metal-binding site [ion binding] 198094009131 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198094009132 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 198094009133 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198094009134 metal-binding site [ion binding] 198094009135 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 198094009136 putative homodimer interface [polypeptide binding]; other site 198094009137 putative homotetramer interface [polypeptide binding]; other site 198094009138 putative allosteric switch controlling residues; other site 198094009139 putative metal binding site [ion binding]; other site 198094009140 putative homodimer-homodimer interface [polypeptide binding]; other site 198094009141 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 198094009142 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198094009143 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198094009144 Walker A/P-loop; other site 198094009145 ATP binding site [chemical binding]; other site 198094009146 Q-loop/lid; other site 198094009147 ABC transporter signature motif; other site 198094009148 Walker B; other site 198094009149 D-loop; other site 198094009150 H-loop/switch region; other site 198094009151 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094009152 ABC-ATPase subunit interface; other site 198094009153 dimer interface [polypeptide binding]; other site 198094009154 putative PBP binding regions; other site 198094009155 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094009156 ABC-ATPase subunit interface; other site 198094009157 dimer interface [polypeptide binding]; other site 198094009158 putative PBP binding regions; other site 198094009159 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 198094009160 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198094009161 putative ligand binding residues [chemical binding]; other site 198094009162 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 198094009163 active site 198094009164 putative catalytic site [active] 198094009165 DNA binding site [nucleotide binding] 198094009166 putative phosphate binding site [ion binding]; other site 198094009167 metal binding site A [ion binding]; metal-binding site 198094009168 AP binding site [nucleotide binding]; other site 198094009169 metal binding site B [ion binding]; metal-binding site 198094009170 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 198094009171 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 198094009172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094009173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094009174 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 198094009175 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 198094009176 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198094009177 DNA binding site [nucleotide binding] 198094009178 active site 198094009179 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 198094009180 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 198094009181 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198094009182 minor groove reading motif; other site 198094009183 helix-hairpin-helix signature motif; other site 198094009184 substrate binding pocket [chemical binding]; other site 198094009185 active site 198094009186 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 198094009187 peptidase T-like protein; Region: PepT-like; TIGR01883 198094009188 metal binding site [ion binding]; metal-binding site 198094009189 dimer interface [polypeptide binding]; other site 198094009190 Predicted membrane protein [Function unknown]; Region: COG2364 198094009191 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094009192 hypothetical protein; Provisional; Region: PRK06764 198094009193 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198094009194 catalytic core [active] 198094009195 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094009196 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094009197 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 198094009198 active site 198094009199 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 198094009200 PAS domain S-box; Region: sensory_box; TIGR00229 198094009201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094009202 putative active site [active] 198094009203 heme pocket [chemical binding]; other site 198094009204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198094009205 metal binding site [ion binding]; metal-binding site 198094009206 active site 198094009207 I-site; other site 198094009208 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198094009209 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 198094009210 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 198094009211 LrgB-like family; Region: LrgB; cl00596 198094009212 holin-like protein; Validated; Region: PRK01658 198094009213 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198094009214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094009215 DNA-binding site [nucleotide binding]; DNA binding site 198094009216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094009217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094009218 homodimer interface [polypeptide binding]; other site 198094009219 catalytic residue [active] 198094009220 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094009221 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094009222 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 198094009223 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 198094009224 active site 198094009225 catalytic site [active] 198094009226 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 198094009227 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 198094009228 putative active site [active] 198094009229 putative catalytic triad [active] 198094009230 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 198094009231 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198094009232 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 198094009233 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198094009234 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 198094009235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094009236 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 198094009237 Sulfatase; Region: Sulfatase; pfam00884 198094009238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094009239 binding surface 198094009240 Tetratricopeptide repeat; Region: TPR_16; pfam13432 198094009241 TPR motif; other site 198094009242 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 198094009243 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 198094009244 G1 box; other site 198094009245 GTP/Mg2+ binding site [chemical binding]; other site 198094009246 Switch I region; other site 198094009247 G3 box; other site 198094009248 Switch II region; other site 198094009249 G4 box; other site 198094009250 G5 box; other site 198094009251 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 198094009252 active site 198094009253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094009254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094009255 dimer interface [polypeptide binding]; other site 198094009256 phosphorylation site [posttranslational modification] 198094009257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094009258 ATP binding site [chemical binding]; other site 198094009259 Mg2+ binding site [ion binding]; other site 198094009260 G-X-G motif; other site 198094009261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094009262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094009263 active site 198094009264 phosphorylation site [posttranslational modification] 198094009265 intermolecular recognition site; other site 198094009266 dimerization interface [polypeptide binding]; other site 198094009267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094009268 DNA binding site [nucleotide binding] 198094009269 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 198094009270 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 198094009271 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 198094009272 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 198094009273 Walker A/P-loop; other site 198094009274 ATP binding site [chemical binding]; other site 198094009275 Q-loop/lid; other site 198094009276 ABC transporter signature motif; other site 198094009277 Walker B; other site 198094009278 D-loop; other site 198094009279 H-loop/switch region; other site 198094009280 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 198094009281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094009282 ATP binding site [chemical binding]; other site 198094009283 Mg2+ binding site [ion binding]; other site 198094009284 G-X-G motif; other site 198094009285 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 198094009286 ATP binding site [chemical binding]; other site 198094009287 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 198094009288 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 198094009289 MutS domain I; Region: MutS_I; pfam01624 198094009290 MutS domain II; Region: MutS_II; pfam05188 198094009291 MutS domain III; Region: MutS_III; pfam05192 198094009292 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 198094009293 Walker A/P-loop; other site 198094009294 ATP binding site [chemical binding]; other site 198094009295 Q-loop/lid; other site 198094009296 ABC transporter signature motif; other site 198094009297 Walker B; other site 198094009298 D-loop; other site 198094009299 H-loop/switch region; other site 198094009300 Outer spore coat protein E (CotE); Region: CotE; pfam10628 198094009301 Predicted membrane protein [Function unknown]; Region: COG4550 198094009302 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 198094009303 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 198094009304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094009305 FeS/SAM binding site; other site 198094009306 TRAM domain; Region: TRAM; pfam01938 198094009307 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 198094009308 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 198094009309 TPP-binding site [chemical binding]; other site 198094009310 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 198094009311 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 198094009312 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 198094009313 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 198094009314 dimer interface [polypeptide binding]; other site 198094009315 PYR/PP interface [polypeptide binding]; other site 198094009316 TPP binding site [chemical binding]; other site 198094009317 substrate binding site [chemical binding]; other site 198094009318 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 198094009319 active site 198094009320 dimer interface [polypeptide binding]; other site 198094009321 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 198094009322 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 198094009323 putative active site [active] 198094009324 metal binding site [ion binding]; metal-binding site 198094009325 homodimer binding site [polypeptide binding]; other site 198094009326 phosphodiesterase; Provisional; Region: PRK12704 198094009327 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094009328 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 198094009329 KH domain; Region: KH_1; pfam00013 198094009330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094009331 Zn2+ binding site [ion binding]; other site 198094009332 Mg2+ binding site [ion binding]; other site 198094009333 recombinase A; Provisional; Region: recA; PRK09354 198094009334 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 198094009335 hexamer interface [polypeptide binding]; other site 198094009336 Walker A motif; other site 198094009337 ATP binding site [chemical binding]; other site 198094009338 Walker B motif; other site 198094009339 competence damage-inducible protein A; Provisional; Region: PRK00549 198094009340 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 198094009341 putative MPT binding site; other site 198094009342 Competence-damaged protein; Region: CinA; pfam02464 198094009343 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 198094009344 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 198094009345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009346 non-specific DNA binding site [nucleotide binding]; other site 198094009347 salt bridge; other site 198094009348 sequence-specific DNA binding site [nucleotide binding]; other site 198094009349 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 198094009350 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 198094009351 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 198094009352 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 198094009353 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 198094009354 classical (c) SDRs; Region: SDR_c; cd05233 198094009355 NAD(P) binding site [chemical binding]; other site 198094009356 active site 198094009357 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 198094009358 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 198094009359 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198094009360 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 198094009361 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198094009362 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 198094009363 TM-ABC transporter signature motif; other site 198094009364 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 198094009365 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198094009366 Walker A/P-loop; other site 198094009367 ATP binding site [chemical binding]; other site 198094009368 Q-loop/lid; other site 198094009369 ABC transporter signature motif; other site 198094009370 Walker B; other site 198094009371 D-loop; other site 198094009372 H-loop/switch region; other site 198094009373 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198094009374 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 198094009375 ligand binding site [chemical binding]; other site 198094009376 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198094009377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094009378 DNA-binding site [nucleotide binding]; DNA binding site 198094009379 UTRA domain; Region: UTRA; pfam07702 198094009380 Tetraspanin family; Region: Tetraspannin; pfam00335 198094009381 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 198094009382 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198094009383 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 198094009384 YlzJ-like protein; Region: YlzJ; pfam14035 198094009385 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 198094009386 active site 198094009387 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 198094009388 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094009389 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 198094009390 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 198094009391 dimer interface [polypeptide binding]; other site 198094009392 active site 198094009393 catalytic residue [active] 198094009394 aspartate kinase I; Reviewed; Region: PRK08210 198094009395 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 198094009396 nucleotide binding site [chemical binding]; other site 198094009397 substrate binding site [chemical binding]; other site 198094009398 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 198094009399 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 198094009400 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 198094009401 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 198094009402 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 198094009403 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 198094009404 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 198094009405 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 198094009406 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 198094009407 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 198094009408 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 198094009409 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198094009410 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 198094009411 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 198094009412 NodB motif; other site 198094009413 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 198094009414 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 198094009415 RNase E interface [polypeptide binding]; other site 198094009416 trimer interface [polypeptide binding]; other site 198094009417 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 198094009418 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 198094009419 RNase E interface [polypeptide binding]; other site 198094009420 trimer interface [polypeptide binding]; other site 198094009421 active site 198094009422 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 198094009423 putative nucleic acid binding region [nucleotide binding]; other site 198094009424 G-X-X-G motif; other site 198094009425 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 198094009426 RNA binding site [nucleotide binding]; other site 198094009427 domain interface; other site 198094009428 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 198094009429 16S/18S rRNA binding site [nucleotide binding]; other site 198094009430 S13e-L30e interaction site [polypeptide binding]; other site 198094009431 25S rRNA binding site [nucleotide binding]; other site 198094009432 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 198094009433 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 198094009434 active site 198094009435 Riboflavin kinase; Region: Flavokinase; smart00904 198094009436 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 198094009437 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 198094009438 RNA binding site [nucleotide binding]; other site 198094009439 active site 198094009440 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 198094009441 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 198094009442 Protein of unknown function (DUF503); Region: DUF503; pfam04456 198094009443 translation initiation factor IF-2; Validated; Region: infB; PRK05306 198094009444 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 198094009445 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 198094009446 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 198094009447 G1 box; other site 198094009448 putative GEF interaction site [polypeptide binding]; other site 198094009449 GTP/Mg2+ binding site [chemical binding]; other site 198094009450 Switch I region; other site 198094009451 G2 box; other site 198094009452 G3 box; other site 198094009453 Switch II region; other site 198094009454 G4 box; other site 198094009455 G5 box; other site 198094009456 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 198094009457 Translation-initiation factor 2; Region: IF-2; pfam11987 198094009458 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 198094009459 hypothetical protein; Provisional; Region: PRK07714 198094009460 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 198094009461 putative RNA binding cleft [nucleotide binding]; other site 198094009462 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 198094009463 NusA N-terminal domain; Region: NusA_N; pfam08529 198094009464 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 198094009465 RNA binding site [nucleotide binding]; other site 198094009466 homodimer interface [polypeptide binding]; other site 198094009467 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 198094009468 G-X-X-G motif; other site 198094009469 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 198094009470 G-X-X-G motif; other site 198094009471 Sm and related proteins; Region: Sm_like; cl00259 198094009472 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 198094009473 putative oligomer interface [polypeptide binding]; other site 198094009474 putative RNA binding site [nucleotide binding]; other site 198094009475 DNA polymerase III PolC; Validated; Region: polC; PRK00448 198094009476 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 198094009477 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 198094009478 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 198094009479 generic binding surface II; other site 198094009480 generic binding surface I; other site 198094009481 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 198094009482 active site 198094009483 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 198094009484 active site 198094009485 catalytic site [active] 198094009486 substrate binding site [chemical binding]; other site 198094009487 putative PHP Thumb interface [polypeptide binding]; other site 198094009488 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 198094009489 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 198094009490 prolyl-tRNA synthetase; Provisional; Region: PRK09194 198094009491 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 198094009492 dimer interface [polypeptide binding]; other site 198094009493 motif 1; other site 198094009494 active site 198094009495 motif 2; other site 198094009496 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 198094009497 putative deacylase active site [active] 198094009498 motif 3; other site 198094009499 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 198094009500 anticodon binding site; other site 198094009501 RIP metalloprotease RseP; Region: TIGR00054 198094009502 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 198094009503 active site 198094009504 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 198094009505 protein binding site [polypeptide binding]; other site 198094009506 putative substrate binding region [chemical binding]; other site 198094009507 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 198094009508 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 198094009509 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 198094009510 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 198094009511 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 198094009512 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 198094009513 active site 198094009514 dimer interface [polypeptide binding]; other site 198094009515 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 198094009516 hinge region; other site 198094009517 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 198094009518 putative nucleotide binding site [chemical binding]; other site 198094009519 uridine monophosphate binding site [chemical binding]; other site 198094009520 homohexameric interface [polypeptide binding]; other site 198094009521 elongation factor Ts; Provisional; Region: tsf; PRK09377 198094009522 UBA/TS-N domain; Region: UBA; pfam00627 198094009523 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 198094009524 rRNA interaction site [nucleotide binding]; other site 198094009525 S8 interaction site; other site 198094009526 putative laminin-1 binding site; other site 198094009527 transcriptional repressor CodY; Validated; Region: PRK04158 198094009528 CodY GAF-like domain; Region: CodY; pfam06018 198094009529 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 198094009530 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 198094009531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094009532 Walker A motif; other site 198094009533 ATP binding site [chemical binding]; other site 198094009534 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 198094009535 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198094009536 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 198094009537 active site 198094009538 HslU subunit interaction site [polypeptide binding]; other site 198094009539 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 198094009540 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 198094009541 active site 198094009542 Int/Topo IB signature motif; other site 198094009543 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 198094009544 Glucose inhibited division protein A; Region: GIDA; pfam01134 198094009545 DNA topoisomerase I; Validated; Region: PRK05582 198094009546 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 198094009547 active site 198094009548 interdomain interaction site; other site 198094009549 putative metal-binding site [ion binding]; other site 198094009550 nucleotide binding site [chemical binding]; other site 198094009551 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198094009552 domain I; other site 198094009553 DNA binding groove [nucleotide binding] 198094009554 phosphate binding site [ion binding]; other site 198094009555 domain II; other site 198094009556 domain III; other site 198094009557 nucleotide binding site [chemical binding]; other site 198094009558 catalytic site [active] 198094009559 domain IV; other site 198094009560 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198094009561 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198094009562 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 198094009563 CoA binding domain; Region: CoA_binding; pfam02629 198094009564 CoA-ligase; Region: Ligase_CoA; pfam00549 198094009565 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 198094009566 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 198094009567 CoA-ligase; Region: Ligase_CoA; pfam00549 198094009568 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 198094009569 RNA/DNA hybrid binding site [nucleotide binding]; other site 198094009570 active site 198094009571 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 198094009572 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 198094009573 GTP/Mg2+ binding site [chemical binding]; other site 198094009574 G4 box; other site 198094009575 G5 box; other site 198094009576 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 198094009577 G1 box; other site 198094009578 G1 box; other site 198094009579 GTP/Mg2+ binding site [chemical binding]; other site 198094009580 Switch I region; other site 198094009581 G2 box; other site 198094009582 G2 box; other site 198094009583 G3 box; other site 198094009584 G3 box; other site 198094009585 Switch II region; other site 198094009586 Switch II region; other site 198094009587 G4 box; other site 198094009588 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 198094009589 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198094009590 Catalytic site [active] 198094009591 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 198094009592 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 198094009593 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 198094009594 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 198094009595 RimM N-terminal domain; Region: RimM; pfam01782 198094009596 PRC-barrel domain; Region: PRC; pfam05239 198094009597 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 198094009598 G-X-X-G motif; other site 198094009599 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 198094009600 signal recognition particle protein; Provisional; Region: PRK10867 198094009601 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 198094009602 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 198094009603 P loop; other site 198094009604 GTP binding site [chemical binding]; other site 198094009605 Signal peptide binding domain; Region: SRP_SPB; pfam02978 198094009606 putative DNA-binding protein; Validated; Region: PRK00118 198094009607 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 198094009608 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 198094009609 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 198094009610 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 198094009611 P loop; other site 198094009612 GTP binding site [chemical binding]; other site 198094009613 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 198094009614 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 198094009615 Walker A/P-loop; other site 198094009616 ATP binding site [chemical binding]; other site 198094009617 Q-loop/lid; other site 198094009618 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 198094009619 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 198094009620 ABC transporter signature motif; other site 198094009621 Walker B; other site 198094009622 D-loop; other site 198094009623 H-loop/switch region; other site 198094009624 ribonuclease III; Reviewed; Region: rnc; PRK00102 198094009625 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 198094009626 dimerization interface [polypeptide binding]; other site 198094009627 active site 198094009628 metal binding site [ion binding]; metal-binding site 198094009629 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 198094009630 dsRNA binding site [nucleotide binding]; other site 198094009631 acyl carrier protein; Provisional; Region: acpP; PRK00982 198094009632 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 198094009633 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 198094009634 NAD(P) binding site [chemical binding]; other site 198094009635 homotetramer interface [polypeptide binding]; other site 198094009636 homodimer interface [polypeptide binding]; other site 198094009637 active site 198094009638 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 198094009639 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 198094009640 putative phosphate acyltransferase; Provisional; Region: PRK05331 198094009641 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 198094009642 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 198094009643 active site 2 [active] 198094009644 active site 1 [active] 198094009645 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 198094009646 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 198094009647 generic binding surface II; other site 198094009648 ssDNA binding site; other site 198094009649 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094009650 ATP binding site [chemical binding]; other site 198094009651 putative Mg++ binding site [ion binding]; other site 198094009652 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094009653 nucleotide binding region [chemical binding]; other site 198094009654 ATP-binding site [chemical binding]; other site 198094009655 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 198094009656 DAK2 domain; Region: Dak2; pfam02734 198094009657 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 198094009658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 198094009659 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 198094009660 Thiamine pyrophosphokinase; Region: TPK; cd07995 198094009661 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 198094009662 active site 198094009663 dimerization interface [polypeptide binding]; other site 198094009664 thiamine binding site [chemical binding]; other site 198094009665 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 198094009666 substrate binding site [chemical binding]; other site 198094009667 hexamer interface [polypeptide binding]; other site 198094009668 metal binding site [ion binding]; metal-binding site 198094009669 GTPase RsgA; Reviewed; Region: PRK00098 198094009670 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 198094009671 RNA binding site [nucleotide binding]; other site 198094009672 homodimer interface [polypeptide binding]; other site 198094009673 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 198094009674 GTPase/Zn-binding domain interface [polypeptide binding]; other site 198094009675 GTP/Mg2+ binding site [chemical binding]; other site 198094009676 G4 box; other site 198094009677 G5 box; other site 198094009678 G1 box; other site 198094009679 Switch I region; other site 198094009680 G2 box; other site 198094009681 G3 box; other site 198094009682 Switch II region; other site 198094009683 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 198094009684 Catalytic domain of Protein Kinases; Region: PKc; cd00180 198094009685 active site 198094009686 ATP binding site [chemical binding]; other site 198094009687 substrate binding site [chemical binding]; other site 198094009688 activation loop (A-loop); other site 198094009689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 198094009690 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 198094009691 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 198094009692 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 198094009693 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 198094009694 active site 198094009695 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 198094009696 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 198094009697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094009698 FeS/SAM binding site; other site 198094009699 16S rRNA methyltransferase B; Provisional; Region: PRK14902 198094009700 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 198094009701 putative RNA binding site [nucleotide binding]; other site 198094009702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094009703 S-adenosylmethionine binding site [chemical binding]; other site 198094009704 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 198094009705 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 198094009706 putative active site [active] 198094009707 substrate binding site [chemical binding]; other site 198094009708 putative cosubstrate binding site; other site 198094009709 catalytic site [active] 198094009710 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 198094009711 substrate binding site [chemical binding]; other site 198094009712 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 198094009713 active site 198094009714 catalytic residues [active] 198094009715 metal binding site [ion binding]; metal-binding site 198094009716 primosome assembly protein PriA; Validated; Region: PRK05580 198094009717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094009718 ATP binding site [chemical binding]; other site 198094009719 putative Mg++ binding site [ion binding]; other site 198094009720 helicase superfamily c-terminal domain; Region: HELICc; smart00490 198094009721 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 198094009722 Flavoprotein; Region: Flavoprotein; cl19190 198094009723 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 198094009724 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 198094009725 Guanylate kinase; Region: Guanylate_kin; pfam00625 198094009726 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 198094009727 catalytic site [active] 198094009728 G-X2-G-X-G-K; other site 198094009729 hypothetical protein; Provisional; Region: PRK04323 198094009730 hypothetical protein; Provisional; Region: PRK11820 198094009731 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 198094009732 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 198094009733 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 198094009734 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 198094009735 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198094009736 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 198094009737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094009738 motif II; other site 198094009739 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 198094009740 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 198094009741 Domain of unknown function (DUF814); Region: DUF814; pfam05670 198094009742 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 198094009743 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 198094009744 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 198094009745 active site 198094009746 YoqO-like protein; Region: YoqO; pfam14037 198094009747 YoqO-like protein; Region: YoqO; pfam14037 198094009748 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 198094009749 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 198094009750 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094009751 active site 198094009752 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 198094009753 active site 198094009754 dimer interface [polypeptide binding]; other site 198094009755 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 198094009756 heterodimer interface [polypeptide binding]; other site 198094009757 active site 198094009758 FMN binding site [chemical binding]; other site 198094009759 homodimer interface [polypeptide binding]; other site 198094009760 substrate binding site [chemical binding]; other site 198094009761 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 198094009762 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 198094009763 FAD binding pocket [chemical binding]; other site 198094009764 FAD binding motif [chemical binding]; other site 198094009765 phosphate binding motif [ion binding]; other site 198094009766 beta-alpha-beta structure motif; other site 198094009767 NAD binding pocket [chemical binding]; other site 198094009768 Iron coordination center [ion binding]; other site 198094009769 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 198094009770 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198094009771 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 198094009772 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 198094009773 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198094009774 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198094009775 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 198094009776 IMP binding site; other site 198094009777 dimer interface [polypeptide binding]; other site 198094009778 interdomain contacts; other site 198094009779 partial ornithine binding site; other site 198094009780 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 198094009781 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 198094009782 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 198094009783 catalytic site [active] 198094009784 subunit interface [polypeptide binding]; other site 198094009785 dihydroorotase; Validated; Region: pyrC; PRK09357 198094009786 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198094009787 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 198094009788 active site 198094009789 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 198094009790 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 198094009791 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 198094009792 Sulfate transporter family; Region: Sulfate_transp; cl19250 198094009793 uracil-xanthine permease; Region: ncs2; TIGR00801 198094009794 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094009795 active site 198094009796 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 198094009797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094009798 RNA binding surface [nucleotide binding]; other site 198094009799 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198094009800 active site 198094009801 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 198094009802 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 198094009803 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 198094009804 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 198094009805 active site 198094009806 HIGH motif; other site 198094009807 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198094009808 KMSKS motif; other site 198094009809 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 198094009810 tRNA binding surface [nucleotide binding]; other site 198094009811 anticodon binding site; other site 198094009812 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198094009813 DivIVA protein; Region: DivIVA; pfam05103 198094009814 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 198094009815 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 198094009816 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094009817 RNA binding surface [nucleotide binding]; other site 198094009818 YGGT family; Region: YGGT; pfam02325 198094009819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 198094009820 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 198094009821 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198094009822 catalytic residue [active] 198094009823 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 198094009824 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 198094009825 sporulation sigma factor SigG; Reviewed; Region: PRK08215 198094009826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094009827 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198094009828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094009829 DNA binding residues [nucleotide binding] 198094009830 sporulation sigma factor SigE; Reviewed; Region: PRK08301 198094009831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094009832 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094009833 DNA binding residues [nucleotide binding] 198094009834 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 198094009835 cell division protein FtsZ; Validated; Region: PRK09330 198094009836 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 198094009837 nucleotide binding site [chemical binding]; other site 198094009838 SulA interaction site; other site 198094009839 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 198094009840 Cell division protein FtsA; Region: FtsA; smart00842 198094009841 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198094009842 nucleotide binding site [chemical binding]; other site 198094009843 Cell division protein FtsA; Region: FtsA; pfam14450 198094009844 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 198094009845 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 198094009846 Cell division protein FtsQ; Region: FtsQ; pfam03799 198094009847 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 198094009848 FAD binding domain; Region: FAD_binding_4; pfam01565 198094009849 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 198094009850 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 198094009851 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 198094009852 active site 198094009853 homodimer interface [polypeptide binding]; other site 198094009854 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 198094009855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094009856 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 198094009857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198094009858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198094009859 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 198094009860 Mg++ binding site [ion binding]; other site 198094009861 putative catalytic motif [active] 198094009862 putative substrate binding site [chemical binding]; other site 198094009863 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 198094009864 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198094009865 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198094009866 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198094009867 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 198094009868 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198094009869 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094009870 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 198094009871 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 198094009872 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198094009873 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094009874 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 198094009875 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 198094009876 Cell division protein FtsL; Region: FtsL; cl11433 198094009877 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 198094009878 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 198094009879 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 198094009880 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 198094009881 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 198094009882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094009883 Coenzyme A binding pocket [chemical binding]; other site 198094009884 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 198094009885 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 198094009886 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 198094009887 Replication-relaxation; Region: Replic_Relax; pfam13814 198094009888 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198094009889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009890 non-specific DNA binding site [nucleotide binding]; other site 198094009891 salt bridge; other site 198094009892 sequence-specific DNA binding site [nucleotide binding]; other site 198094009893 hypothetical protein; Region: PHA02436 198094009894 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198094009895 amidase catalytic site [active] 198094009896 Zn binding residues [ion binding]; other site 198094009897 substrate binding site [chemical binding]; other site 198094009898 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 198094009899 Holin family; Region: Phage_holin_4; pfam05105 198094009900 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 198094009901 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 198094009902 active site 198094009903 catalytic residues [active] 198094009904 DNA binding site [nucleotide binding] 198094009905 Int/Topo IB signature motif; other site 198094009906 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 198094009907 Phage tail protein; Region: Sipho_tail; cl17486 198094009908 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 198094009909 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 198094009910 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 198094009911 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 198094009912 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 198094009913 oligomerization interface [polypeptide binding]; other site 198094009914 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198094009915 Interdomain contacts; other site 198094009916 Cytokine receptor motif; other site 198094009917 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 198094009918 Phage capsid family; Region: Phage_capsid; pfam05065 198094009919 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 198094009920 oligomer interface [polypeptide binding]; other site 198094009921 active site residues [active] 198094009922 Phage portal protein; Region: Phage_portal; pfam04860 198094009923 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 198094009924 Phage Terminase; Region: Terminase_1; cl19862 198094009925 Phage terminase, small subunit; Region: Terminase_4; pfam05119 198094009926 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198094009927 active site 198094009928 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 198094009929 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 198094009930 Int/Topo IB signature motif; other site 198094009931 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 198094009932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094009933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009934 non-specific DNA binding site [nucleotide binding]; other site 198094009935 salt bridge; other site 198094009936 sequence-specific DNA binding site [nucleotide binding]; other site 198094009937 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 198094009938 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 198094009939 active site 198094009940 metal binding site [ion binding]; metal-binding site 198094009941 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 198094009942 trimer interface [polypeptide binding]; other site 198094009943 active site 198094009944 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 198094009945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094009946 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198094009947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009948 sequence-specific DNA binding site [nucleotide binding]; other site 198094009949 salt bridge; other site 198094009950 Helix-turn-helix domain; Region: HTH_38; pfam13936 198094009951 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 198094009952 hypothetical protein; Validated; Region: PRK08116 198094009953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094009954 Walker A motif; other site 198094009955 ATP binding site [chemical binding]; other site 198094009956 Walker B motif; other site 198094009957 Helix-turn-helix domain; Region: HTH_36; pfam13730 198094009958 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 198094009959 Inositol polyphosphate kinase; Region: IPK; cl12283 198094009960 Helix-turn-helix domain; Region: HTH_17; pfam12728 198094009961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009962 non-specific DNA binding site [nucleotide binding]; other site 198094009963 salt bridge; other site 198094009964 sequence-specific DNA binding site [nucleotide binding]; other site 198094009965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009966 non-specific DNA binding site [nucleotide binding]; other site 198094009967 salt bridge; other site 198094009968 sequence-specific DNA binding site [nucleotide binding]; other site 198094009969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094009970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094009971 non-specific DNA binding site [nucleotide binding]; other site 198094009972 salt bridge; other site 198094009973 sequence-specific DNA binding site [nucleotide binding]; other site 198094009974 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 198094009975 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 198094009976 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 198094009977 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 198094009978 Int/Topo IB signature motif; other site 198094009979 hypothetical protein; Provisional; Region: PRK13670 198094009980 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 198094009981 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 198094009982 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 198094009983 protein binding site [polypeptide binding]; other site 198094009984 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198094009985 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 198094009986 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 198094009987 active site 198094009988 nucleophile elbow; other site 198094009989 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 198094009990 Nucleoside recognition; Region: Gate; pfam07670 198094009991 Nucleoside recognition; Region: Gate; pfam07670 198094009992 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 198094009993 active site 198094009994 (T/H)XGH motif; other site 198094009995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094009996 S-adenosylmethionine binding site [chemical binding]; other site 198094009997 hypothetical protein; Provisional; Region: PRK02886 198094009998 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 198094009999 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198094010000 catalytic core [active] 198094010001 YlbE-like protein; Region: YlbE; pfam14003 198094010002 Putative coat protein; Region: YlbD_coat; pfam14071 198094010003 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 198094010004 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 198094010005 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 198094010006 YugN-like family; Region: YugN; pfam08868 198094010007 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 198094010008 multimer interface [polypeptide binding]; other site 198094010009 active site 198094010010 catalytic triad [active] 198094010011 dimer interface [polypeptide binding]; other site 198094010012 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 198094010013 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 198094010014 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 198094010015 Subunit I/III interface [polypeptide binding]; other site 198094010016 Subunit III/IV interface [polypeptide binding]; other site 198094010017 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 198094010018 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 198094010019 D-pathway; other site 198094010020 Putative ubiquinol binding site [chemical binding]; other site 198094010021 Low-spin heme (heme b) binding site [chemical binding]; other site 198094010022 Putative water exit pathway; other site 198094010023 Binuclear center (heme o3/CuB) [ion binding]; other site 198094010024 K-pathway; other site 198094010025 Putative proton exit pathway; other site 198094010026 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 198094010027 The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213 198094010028 oligomer interface [polypeptide binding]; other site 198094010029 CuA binuclear center [ion binding]; other site 198094010030 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 198094010031 Cytochrome c; Region: Cytochrom_C; pfam00034 198094010032 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 198094010033 putative active site [active] 198094010034 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 198094010035 pyruvate carboxylase; Reviewed; Region: PRK12999 198094010036 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198094010037 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 198094010038 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 198094010039 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 198094010040 active site 198094010041 catalytic residues [active] 198094010042 metal binding site [ion binding]; metal-binding site 198094010043 homodimer binding site [polypeptide binding]; other site 198094010044 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 198094010045 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198094010046 carboxyltransferase (CT) interaction site; other site 198094010047 biotinylation site [posttranslational modification]; other site 198094010048 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 198094010049 hypothetical protein; Provisional; Region: PRK13666 198094010050 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 198094010051 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 198094010052 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 198094010053 putative active site [active] 198094010054 PhoH-like protein; Region: PhoH; pfam02562 198094010055 hypothetical protein; Provisional; Region: PRK06733 198094010056 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 198094010057 YlaH-like protein; Region: YlaH; pfam14036 198094010058 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 198094010059 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 198094010060 G1 box; other site 198094010061 putative GEF interaction site [polypeptide binding]; other site 198094010062 GTP/Mg2+ binding site [chemical binding]; other site 198094010063 Switch I region; other site 198094010064 G2 box; other site 198094010065 G3 box; other site 198094010066 Switch II region; other site 198094010067 G4 box; other site 198094010068 G5 box; other site 198094010069 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 198094010070 Elongation Factor G, domain II; Region: EFG_II; pfam14492 198094010071 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 198094010072 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 198094010073 active site 198094010074 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 198094010075 hypothetical protein; Provisional; Region: PRK04387 198094010076 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 198094010077 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198094010078 homodimer interface [polypeptide binding]; other site 198094010079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010080 catalytic residue [active] 198094010081 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198094010082 transglutaminase; Provisional; Region: tgl; PRK03187 198094010083 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 198094010084 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 198094010085 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 198094010086 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 198094010087 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 198094010088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094010089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094010090 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 198094010091 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 198094010092 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198094010093 E3 interaction surface; other site 198094010094 lipoyl attachment site [posttranslational modification]; other site 198094010095 e3 binding domain; Region: E3_binding; pfam02817 198094010096 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198094010097 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 198094010098 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 198094010099 alpha subunit interface [polypeptide binding]; other site 198094010100 TPP binding site [chemical binding]; other site 198094010101 heterodimer interface [polypeptide binding]; other site 198094010102 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198094010103 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 198094010104 TPP-binding site [chemical binding]; other site 198094010105 heterodimer interface [polypeptide binding]; other site 198094010106 tetramer interface [polypeptide binding]; other site 198094010107 phosphorylation loop region [posttranslational modification] 198094010108 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 198094010109 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 198094010110 active site 198094010111 catalytic residues [active] 198094010112 metal binding site [ion binding]; metal-binding site 198094010113 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 198094010114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094010115 active site 198094010116 motif I; other site 198094010117 motif II; other site 198094010118 hypothetical protein; Provisional; Region: PRK13667 198094010119 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 198094010120 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094010121 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 198094010122 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 198094010123 TrkA-N domain; Region: TrkA_N; pfam02254 198094010124 TrkA-C domain; Region: TrkA_C; pfam02080 198094010125 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 198094010126 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198094010127 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 198094010128 metal binding site [ion binding]; metal-binding site 198094010129 putative dimer interface [polypeptide binding]; other site 198094010130 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 198094010131 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 198094010132 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 198094010133 trimer interface [polypeptide binding]; other site 198094010134 active site 198094010135 substrate binding site [chemical binding]; other site 198094010136 CoA binding site [chemical binding]; other site 198094010137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094010138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094010139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198094010140 dimerization interface [polypeptide binding]; other site 198094010141 FOG: CBS domain [General function prediction only]; Region: COG0517 198094010142 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 198094010143 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 198094010144 Protein of unknown function (DUF458); Region: DUF458; pfam04308 198094010145 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 198094010146 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 198094010147 catalytic residues [active] 198094010148 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 198094010149 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198094010150 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 198094010151 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 198094010152 short chain dehydrogenase; Provisional; Region: PRK07677 198094010153 NAD(P) binding site [chemical binding]; other site 198094010154 substrate binding site [chemical binding]; other site 198094010155 homotetramer interface [polypeptide binding]; other site 198094010156 active site 198094010157 homodimer interface [polypeptide binding]; other site 198094010158 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 198094010159 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 198094010160 putative active site [active] 198094010161 putative metal binding site [ion binding]; other site 198094010162 polyphosphate kinase; Provisional; Region: PRK05443 198094010163 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 198094010164 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 198094010165 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 198094010166 putative domain interface [polypeptide binding]; other site 198094010167 putative active site [active] 198094010168 catalytic site [active] 198094010169 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 198094010170 putative domain interface [polypeptide binding]; other site 198094010171 putative active site [active] 198094010172 catalytic site [active] 198094010173 exopolyphosphatase; Region: exo_poly_only; TIGR03706 198094010174 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 198094010175 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198094010176 nucleotide binding site [chemical binding]; other site 198094010177 YkyB-like protein; Region: YkyB; pfam14177 198094010178 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 198094010179 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 198094010180 metal binding site [ion binding]; metal-binding site 198094010181 Phage lysis protein, holin; Region: Phage_holin; cl04675 198094010182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094010183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094010184 putative substrate translocation pore; other site 198094010185 Predicted transcriptional regulators [Transcription]; Region: COG1695 198094010186 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 198094010187 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 198094010188 THF binding site; other site 198094010189 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 198094010190 substrate binding site [chemical binding]; other site 198094010191 THF binding site; other site 198094010192 zinc-binding site [ion binding]; other site 198094010193 Competence protein J (ComJ); Region: ComJ; pfam11033 198094010194 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 198094010195 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 198094010196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094010197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094010198 dimer interface [polypeptide binding]; other site 198094010199 phosphorylation site [posttranslational modification] 198094010200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094010201 ATP binding site [chemical binding]; other site 198094010202 Mg2+ binding site [ion binding]; other site 198094010203 G-X-G motif; other site 198094010204 aminotransferase A; Validated; Region: PRK07683 198094010205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094010206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010207 homodimer interface [polypeptide binding]; other site 198094010208 catalytic residue [active] 198094010209 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094010210 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094010211 DNA binding site [nucleotide binding] 198094010212 domain linker motif; other site 198094010213 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 198094010214 putative dimerization interface [polypeptide binding]; other site 198094010215 putative ligand binding site [chemical binding]; other site 198094010216 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198094010217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094010218 dimer interface [polypeptide binding]; other site 198094010219 conserved gate region; other site 198094010220 putative PBP binding loops; other site 198094010221 ABC-ATPase subunit interface; other site 198094010222 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198094010223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094010224 dimer interface [polypeptide binding]; other site 198094010225 conserved gate region; other site 198094010226 putative PBP binding loops; other site 198094010227 ABC-ATPase subunit interface; other site 198094010228 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 198094010229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198094010230 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 198094010231 homodimer interface [polypeptide binding]; other site 198094010232 maltodextrin glucosidase; Provisional; Region: PRK10785 198094010233 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 198094010234 active site 198094010235 homodimer interface [polypeptide binding]; other site 198094010236 catalytic site [active] 198094010237 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 198094010238 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 198094010239 Ca binding site [ion binding]; other site 198094010240 active site 198094010241 catalytic site [active] 198094010242 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 198094010243 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198094010244 Walker A/P-loop; other site 198094010245 ATP binding site [chemical binding]; other site 198094010246 Q-loop/lid; other site 198094010247 ABC transporter signature motif; other site 198094010248 Walker B; other site 198094010249 D-loop; other site 198094010250 H-loop/switch region; other site 198094010251 TOBE domain; Region: TOBE_2; pfam08402 198094010252 hypothetical protein; Provisional; Region: PRK06720 198094010253 NAD(P) binding site [chemical binding]; other site 198094010254 RDD family; Region: RDD; pfam06271 198094010255 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 198094010256 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 198094010257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094010258 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 198094010259 Walker A/P-loop; other site 198094010260 ATP binding site [chemical binding]; other site 198094010261 Q-loop/lid; other site 198094010262 ABC transporter signature motif; other site 198094010263 Walker B; other site 198094010264 D-loop; other site 198094010265 H-loop/switch region; other site 198094010266 putative acyltransferase; Provisional; Region: PRK05790 198094010267 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198094010268 dimer interface [polypeptide binding]; other site 198094010269 active site 198094010270 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 198094010271 nudix motif; other site 198094010272 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 198094010273 hypothetical protein; Validated; Region: PRK07668 198094010274 hypothetical protein; Validated; Region: PRK07668 198094010275 hypothetical protein; Validated; Region: PRK07668 198094010276 Predicted transcriptional regulators [Transcription]; Region: COG1695 198094010277 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 198094010278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094010279 NAD(P) binding site [chemical binding]; other site 198094010280 active site 198094010281 YvrJ protein family; Region: YvrJ; pfam12841 198094010282 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 198094010283 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 198094010284 Phosphotransferase enzyme family; Region: APH; pfam01636 198094010285 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 198094010286 putative active site [active] 198094010287 catalytic triad [active] 198094010288 putative dimer interface [polypeptide binding]; other site 198094010289 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 198094010290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094010291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010292 homodimer interface [polypeptide binding]; other site 198094010293 catalytic residue [active] 198094010294 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 198094010295 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 198094010296 dimer interface [polypeptide binding]; other site 198094010297 active site 198094010298 catalytic residue [active] 198094010299 metal binding site [ion binding]; metal-binding site 198094010300 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 198094010301 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 198094010302 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 198094010303 intersubunit interface [polypeptide binding]; other site 198094010304 active site 198094010305 Zn2+ binding site [ion binding]; other site 198094010306 Cupin domain; Region: Cupin_2; cl17218 198094010307 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 198094010308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198094010309 metal binding site [ion binding]; metal-binding site 198094010310 active site 198094010311 I-site; other site 198094010312 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 198094010313 dimer interface [polypeptide binding]; other site 198094010314 FMN binding site [chemical binding]; other site 198094010315 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 198094010316 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 198094010317 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 198094010318 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198094010319 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198094010320 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198094010321 dimerization domain swap beta strand [polypeptide binding]; other site 198094010322 regulatory protein interface [polypeptide binding]; other site 198094010323 active site 198094010324 regulatory phosphorylation site [posttranslational modification]; other site 198094010325 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198094010326 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 198094010327 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198094010328 active site turn [active] 198094010329 phosphorylation site [posttranslational modification] 198094010330 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198094010331 HPr interaction site; other site 198094010332 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198094010333 active site 198094010334 phosphorylation site [posttranslational modification] 198094010335 transcriptional antiterminator BglG; Provisional; Region: PRK09772 198094010336 CAT RNA binding domain; Region: CAT_RBD; smart01061 198094010337 PRD domain; Region: PRD; pfam00874 198094010338 PRD domain; Region: PRD; pfam00874 198094010339 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 198094010340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094010341 active site 198094010342 motif I; other site 198094010343 motif II; other site 198094010344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094010345 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094010346 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198094010347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094010348 DNA-binding site [nucleotide binding]; DNA binding site 198094010349 UTRA domain; Region: UTRA; pfam07702 198094010350 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 198094010351 active site 198094010352 trimer interface [polypeptide binding]; other site 198094010353 allosteric site; other site 198094010354 active site lid [active] 198094010355 hexamer (dimer of trimers) interface [polypeptide binding]; other site 198094010356 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 198094010357 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 198094010358 active site 198094010359 dimer interface [polypeptide binding]; other site 198094010360 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 198094010361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094010362 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 198094010363 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 198094010364 Domain of unknown function (DUF309); Region: DUF309; pfam03745 198094010365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094010366 Coenzyme A binding pocket [chemical binding]; other site 198094010367 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 198094010368 active site 198094010369 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 198094010370 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 198094010371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094010372 active site 198094010373 motif I; other site 198094010374 motif II; other site 198094010375 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 198094010376 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094010377 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 198094010378 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 198094010379 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 198094010380 stage V sporulation protein AD; Validated; Region: PRK08304 198094010381 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 198094010382 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 198094010383 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 198094010384 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 198094010385 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 198094010386 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 198094010387 Na2 binding site [ion binding]; other site 198094010388 putative substrate binding site 1 [chemical binding]; other site 198094010389 Na binding site 1 [ion binding]; other site 198094010390 putative substrate binding site 2 [chemical binding]; other site 198094010391 sporulation sigma factor SigF; Validated; Region: PRK05572 198094010392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094010393 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198094010394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094010395 DNA binding residues [nucleotide binding] 198094010396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094010397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094010398 ATP binding site [chemical binding]; other site 198094010399 Mg2+ binding site [ion binding]; other site 198094010400 G-X-G motif; other site 198094010401 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 198094010402 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198094010403 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 198094010404 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 198094010405 Predicted transcriptional regulators [Transcription]; Region: COG1725 198094010406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094010407 DNA-binding site [nucleotide binding]; DNA binding site 198094010408 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094010409 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094010410 Walker A/P-loop; other site 198094010411 ATP binding site [chemical binding]; other site 198094010412 Q-loop/lid; other site 198094010413 ABC transporter signature motif; other site 198094010414 Walker B; other site 198094010415 D-loop; other site 198094010416 H-loop/switch region; other site 198094010417 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 198094010418 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094010419 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094010420 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 198094010421 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198094010422 Sulfate transporter family; Region: Sulfate_transp; cl19250 198094010423 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 198094010424 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 198094010425 oligomer interface [polypeptide binding]; other site 198094010426 metal binding site [ion binding]; metal-binding site 198094010427 metal binding site [ion binding]; metal-binding site 198094010428 putative Cl binding site [ion binding]; other site 198094010429 aspartate ring; other site 198094010430 basic sphincter; other site 198094010431 hydrophobic gate; other site 198094010432 periplasmic entrance; other site 198094010433 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 198094010434 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198094010435 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198094010436 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 198094010437 purine nucleoside phosphorylase; Provisional; Region: PRK08202 198094010438 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 198094010439 phosphopentomutase; Provisional; Region: PRK05362 198094010440 YtkA-like; Region: YtkA; pfam13115 198094010441 YtkA-like; Region: YtkA; pfam13115 198094010442 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 198094010443 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 198094010444 active site 198094010445 Int/Topo IB signature motif; other site 198094010446 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 198094010447 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198094010448 metal binding site 2 [ion binding]; metal-binding site 198094010449 putative DNA binding helix; other site 198094010450 metal binding site 1 [ion binding]; metal-binding site 198094010451 dimer interface [polypeptide binding]; other site 198094010452 structural Zn2+ binding site [ion binding]; other site 198094010453 stage II sporulation protein M; Region: spo_II_M; TIGR02831 198094010454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094010455 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198094010456 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198094010457 dimer interface [polypeptide binding]; other site 198094010458 ADP-ribose binding site [chemical binding]; other site 198094010459 active site 198094010460 nudix motif; other site 198094010461 metal binding site [ion binding]; metal-binding site 198094010462 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 198094010463 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094010464 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 198094010465 active site 198094010466 catalytic tetrad [active] 198094010467 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094010468 active site 198094010469 catalytic tetrad [active] 198094010470 GrpB protein; Region: GrpB; pfam04229 198094010471 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 198094010472 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 198094010473 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 198094010474 putative active site [active] 198094010475 putative metal binding site [ion binding]; other site 198094010476 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198094010477 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 198094010478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094010479 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094010480 Predicted permease [General function prediction only]; Region: COG2056 198094010481 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 198094010482 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 198094010483 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094010484 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094010485 DNA binding site [nucleotide binding] 198094010486 domain linker motif; other site 198094010487 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 198094010488 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198094010489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094010490 Coenzyme A binding pocket [chemical binding]; other site 198094010491 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 198094010492 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094010493 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 198094010494 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 198094010495 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 198094010496 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 198094010497 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 198094010498 catalytic motif [active] 198094010499 Zn binding site [ion binding]; other site 198094010500 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 198094010501 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 198094010502 Lumazine binding domain; Region: Lum_binding; pfam00677 198094010503 Lumazine binding domain; Region: Lum_binding; pfam00677 198094010504 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 198094010505 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 198094010506 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 198094010507 dimerization interface [polypeptide binding]; other site 198094010508 active site 198094010509 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 198094010510 homopentamer interface [polypeptide binding]; other site 198094010511 active site 198094010512 biotin synthase; Validated; Region: PRK06256 198094010513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094010514 FeS/SAM binding site; other site 198094010515 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 198094010516 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 198094010517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094010518 S-adenosylmethionine binding site [chemical binding]; other site 198094010519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094010520 Protein of unknown function (DUF452); Region: DUF452; cl01062 198094010521 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094010522 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 198094010523 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 198094010524 substrate-cofactor binding pocket; other site 198094010525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010526 catalytic residue [active] 198094010527 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 198094010528 AAA domain; Region: AAA_26; pfam13500 198094010529 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198094010530 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094010531 inhibitor-cofactor binding pocket; inhibition site 198094010532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010533 catalytic residue [active] 198094010534 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198094010535 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 198094010536 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 198094010537 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 198094010538 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 198094010539 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 198094010540 active site 198094010541 metal binding site [ion binding]; metal-binding site 198094010542 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198094010543 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 198094010544 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 198094010545 active site 198094010546 catalytic triad [active] 198094010547 oxyanion hole [active] 198094010548 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094010549 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094010550 dimerization interface [polypeptide binding]; other site 198094010551 putative DNA binding site [nucleotide binding]; other site 198094010552 putative Zn2+ binding site [ion binding]; other site 198094010553 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 198094010554 ornithine carbamoyltransferase; Provisional; Region: PRK00779 198094010555 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 198094010556 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 198094010557 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198094010558 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094010559 inhibitor-cofactor binding pocket; inhibition site 198094010560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010561 catalytic residue [active] 198094010562 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 198094010563 nucleotide binding site [chemical binding]; other site 198094010564 N-acetyl-L-glutamate binding site [chemical binding]; other site 198094010565 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 198094010566 heterotetramer interface [polypeptide binding]; other site 198094010567 active site pocket [active] 198094010568 cleavage site 198094010569 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 198094010570 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 198094010571 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 198094010572 YqzH-like protein; Region: YqzH; pfam14164 198094010573 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 198094010574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094010575 NAD(P) binding site [chemical binding]; other site 198094010576 active site 198094010577 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 198094010578 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 198094010579 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 198094010580 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 198094010581 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 198094010582 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 198094010583 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198094010584 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 198094010585 putative L-serine binding site [chemical binding]; other site 198094010586 ribonuclease Z; Region: RNase_Z; TIGR02651 198094010587 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 198094010588 DNA polymerase IV; Validated; Region: PRK01810 198094010589 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 198094010590 active site 198094010591 DNA binding site [nucleotide binding] 198094010592 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 198094010593 peptidase T-like protein; Region: PepT-like; TIGR01883 198094010594 metal binding site [ion binding]; metal-binding site 198094010595 putative dimer interface [polypeptide binding]; other site 198094010596 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094010597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094010598 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 198094010599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 198094010600 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198094010601 Predicted membrane protein [Function unknown]; Region: COG4129 198094010602 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 198094010603 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 198094010604 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198094010605 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198094010606 Walker A/P-loop; other site 198094010607 ATP binding site [chemical binding]; other site 198094010608 Q-loop/lid; other site 198094010609 ABC transporter signature motif; other site 198094010610 Walker B; other site 198094010611 D-loop; other site 198094010612 H-loop/switch region; other site 198094010613 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 198094010614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094010615 dimer interface [polypeptide binding]; other site 198094010616 conserved gate region; other site 198094010617 putative PBP binding loops; other site 198094010618 ABC-ATPase subunit interface; other site 198094010619 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198094010620 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198094010621 substrate binding pocket [chemical binding]; other site 198094010622 membrane-bound complex binding site; other site 198094010623 hinge residues; other site 198094010624 Disulphide isomerase; Region: Disulph_isomer; pfam06491 198094010625 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 198094010626 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 198094010627 nudix motif; other site 198094010628 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 198094010629 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 198094010630 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198094010631 E3 interaction surface; other site 198094010632 lipoyl attachment site [posttranslational modification]; other site 198094010633 e3 binding domain; Region: E3_binding; pfam02817 198094010634 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198094010635 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 198094010636 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 198094010637 alpha subunit interface [polypeptide binding]; other site 198094010638 TPP binding site [chemical binding]; other site 198094010639 heterodimer interface [polypeptide binding]; other site 198094010640 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198094010641 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 198094010642 tetramer interface [polypeptide binding]; other site 198094010643 TPP-binding site [chemical binding]; other site 198094010644 heterodimer interface [polypeptide binding]; other site 198094010645 phosphorylation loop region [posttranslational modification] 198094010646 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 198094010647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094010648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094010649 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 198094010650 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198094010651 nucleotide binding site [chemical binding]; other site 198094010652 Acetokinase family; Region: Acetate_kinase; cl17229 198094010653 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 198094010654 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 198094010655 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 198094010656 NAD binding site [chemical binding]; other site 198094010657 Phe binding site; other site 198094010658 phosphate butyryltransferase; Validated; Region: PRK07742 198094010659 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 198094010660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094010661 putative active site [active] 198094010662 heme pocket [chemical binding]; other site 198094010663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094010664 putative active site [active] 198094010665 heme pocket [chemical binding]; other site 198094010666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094010667 Walker A motif; other site 198094010668 ATP binding site [chemical binding]; other site 198094010669 Walker B motif; other site 198094010670 arginine finger; other site 198094010671 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198094010672 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 198094010673 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 198094010674 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 198094010675 active site 198094010676 catalytic site [active] 198094010677 metal binding site [ion binding]; metal-binding site 198094010678 dimer interface [polypeptide binding]; other site 198094010679 YycC-like protein; Region: YycC; pfam14174 198094010680 conserved hypothetical integral membrane protein; Region: TIGR03766 198094010681 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 198094010682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094010683 active site 198094010684 phosphorylation site [posttranslational modification] 198094010685 intermolecular recognition site; other site 198094010686 dimerization interface [polypeptide binding]; other site 198094010687 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 198094010688 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 198094010689 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 198094010690 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 198094010691 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 198094010692 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 198094010693 Walker A/P-loop; other site 198094010694 ATP binding site [chemical binding]; other site 198094010695 Q-loop/lid; other site 198094010696 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 198094010697 ABC transporter signature motif; other site 198094010698 Walker B; other site 198094010699 D-loop; other site 198094010700 H-loop/switch region; other site 198094010701 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 198094010702 arginine repressor; Provisional; Region: PRK04280 198094010703 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 198094010704 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 198094010705 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094010706 RNA binding surface [nucleotide binding]; other site 198094010707 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 198094010708 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 198094010709 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 198094010710 TPP-binding site; other site 198094010711 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198094010712 PYR/PP interface [polypeptide binding]; other site 198094010713 dimer interface [polypeptide binding]; other site 198094010714 TPP binding site [chemical binding]; other site 198094010715 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198094010716 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 198094010717 substrate binding pocket [chemical binding]; other site 198094010718 chain length determination region; other site 198094010719 active site lid residues [active] 198094010720 substrate-Mg2+ binding site; other site 198094010721 catalytic residues [active] 198094010722 aspartate-rich region 1; other site 198094010723 aspartate-rich region 2; other site 198094010724 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 198094010725 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 198094010726 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 198094010727 generic binding surface II; other site 198094010728 generic binding surface I; other site 198094010729 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 198094010730 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 198094010731 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 198094010732 homodimer interface [polypeptide binding]; other site 198094010733 NADP binding site [chemical binding]; other site 198094010734 substrate binding site [chemical binding]; other site 198094010735 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 198094010736 putative RNA binding site [nucleotide binding]; other site 198094010737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 198094010738 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 198094010739 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198094010740 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198094010741 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 198094010742 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 198094010743 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198094010744 carboxyltransferase (CT) interaction site; other site 198094010745 biotinylation site [posttranslational modification]; other site 198094010746 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 198094010747 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 198094010748 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 198094010749 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 198094010750 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 198094010751 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 198094010752 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 198094010753 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 198094010754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094010755 Walker A motif; other site 198094010756 ATP binding site [chemical binding]; other site 198094010757 Walker B motif; other site 198094010758 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 198094010759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094010760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094010761 elongation factor P; Validated; Region: PRK00529 198094010762 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 198094010763 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 198094010764 RNA binding site [nucleotide binding]; other site 198094010765 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 198094010766 RNA binding site [nucleotide binding]; other site 198094010767 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 198094010768 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 198094010769 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 198094010770 active site 198094010771 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 198094010772 trimer interface [polypeptide binding]; other site 198094010773 active site 198094010774 dimer interface [polypeptide binding]; other site 198094010775 Conserved membrane protein YqhR; Region: YqhR; pfam11085 198094010776 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 198094010777 CCC1-related family of proteins; Region: CCC1_like; cl00278 198094010778 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 198094010779 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 198094010780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094010781 motif II; other site 198094010782 manganese transport transcriptional regulator; Provisional; Region: PRK03902 198094010783 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 198094010784 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 198094010785 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 198094010786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094010787 FeS/SAM binding site; other site 198094010788 ribonuclease E; Reviewed; Region: rne; PRK10811 198094010789 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 198094010790 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198094010791 active site residue [active] 198094010792 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094010793 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094010794 DNA binding site [nucleotide binding] 198094010795 domain linker motif; other site 198094010796 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 198094010797 putative dimerization interface [polypeptide binding]; other site 198094010798 putative ligand binding site [chemical binding]; other site 198094010799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094010800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094010801 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 198094010802 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 198094010803 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 198094010804 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 198094010805 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 198094010806 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 198094010807 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094010808 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094010809 Walker A/P-loop; other site 198094010810 ATP binding site [chemical binding]; other site 198094010811 Q-loop/lid; other site 198094010812 ABC transporter signature motif; other site 198094010813 Walker B; other site 198094010814 D-loop; other site 198094010815 H-loop/switch region; other site 198094010816 Predicted transcriptional regulators [Transcription]; Region: COG1725 198094010817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094010818 DNA-binding site [nucleotide binding]; DNA binding site 198094010819 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 198094010820 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 198094010821 tetramer interface [polypeptide binding]; other site 198094010822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010823 catalytic residue [active] 198094010824 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 198094010825 tetramer interface [polypeptide binding]; other site 198094010826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010827 catalytic residue [active] 198094010828 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 198094010829 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 198094010830 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 198094010831 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 198094010832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094010833 ATP binding site [chemical binding]; other site 198094010834 putative Mg++ binding site [ion binding]; other site 198094010835 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 198094010836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094010837 nucleotide binding region [chemical binding]; other site 198094010838 ATP-binding site [chemical binding]; other site 198094010839 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 198094010840 YqzE-like protein; Region: YqzE; pfam14038 198094010841 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 198094010842 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 198094010843 ADP binding site [chemical binding]; other site 198094010844 magnesium binding site [ion binding]; other site 198094010845 putative shikimate binding site; other site 198094010846 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 198094010847 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 198094010848 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 198094010849 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 198094010850 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 198094010851 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 198094010852 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198094010853 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198094010854 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198094010855 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198094010856 Walker A motif; other site 198094010857 ATP binding site [chemical binding]; other site 198094010858 Walker B motif; other site 198094010859 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094010860 putative DNA binding site [nucleotide binding]; other site 198094010861 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 198094010862 putative Zn2+ binding site [ion binding]; other site 198094010863 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 198094010864 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 198094010865 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 198094010866 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 198094010867 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 198094010868 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 198094010869 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 198094010870 active site 198094010871 homodimer interface [polypeptide binding]; other site 198094010872 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 198094010873 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 198094010874 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 198094010875 substrate binding pocket [chemical binding]; other site 198094010876 dimer interface [polypeptide binding]; other site 198094010877 inhibitor binding site; inhibition site 198094010878 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 198094010879 B12 binding site [chemical binding]; other site 198094010880 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 198094010881 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 198094010882 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 198094010883 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 198094010884 FAD binding site [chemical binding]; other site 198094010885 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198094010886 homodimer interface [polypeptide binding]; other site 198094010887 substrate-cofactor binding pocket; other site 198094010888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010889 catalytic residue [active] 198094010890 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198094010891 homodimer interface [polypeptide binding]; other site 198094010892 substrate-cofactor binding pocket; other site 198094010893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094010894 catalytic residue [active] 198094010895 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094010896 dimerization interface [polypeptide binding]; other site 198094010897 putative DNA binding site [nucleotide binding]; other site 198094010898 putative Zn2+ binding site [ion binding]; other site 198094010899 Uncharacterized conserved protein [Function unknown]; Region: COG1565 198094010900 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 198094010901 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198094010902 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 198094010903 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 198094010904 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198094010905 nucleotide binding site [chemical binding]; other site 198094010906 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 198094010907 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 198094010908 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 198094010909 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 198094010910 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 198094010911 active site 198094010912 Substrate binding site; other site 198094010913 Mg++ binding site; other site 198094010914 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 198094010915 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 198094010916 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 198094010917 active site 198094010918 metal binding site [ion binding]; metal-binding site 198094010919 substrate binding site [chemical binding]; other site 198094010920 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 198094010921 PhoU domain; Region: PhoU; pfam01895 198094010922 PhoU domain; Region: PhoU; pfam01895 198094010923 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 198094010924 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 198094010925 Walker A/P-loop; other site 198094010926 ATP binding site [chemical binding]; other site 198094010927 Q-loop/lid; other site 198094010928 ABC transporter signature motif; other site 198094010929 Walker B; other site 198094010930 D-loop; other site 198094010931 H-loop/switch region; other site 198094010932 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 198094010933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094010934 dimer interface [polypeptide binding]; other site 198094010935 conserved gate region; other site 198094010936 putative PBP binding loops; other site 198094010937 ABC-ATPase subunit interface; other site 198094010938 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 198094010939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094010940 dimer interface [polypeptide binding]; other site 198094010941 conserved gate region; other site 198094010942 putative PBP binding loops; other site 198094010943 ABC-ATPase subunit interface; other site 198094010944 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 198094010945 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 198094010946 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198094010947 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094010948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094010949 putative substrate translocation pore; other site 198094010950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094010951 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 198094010952 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 198094010953 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 198094010954 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 198094010955 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 198094010956 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 198094010957 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198094010958 metal binding site 2 [ion binding]; metal-binding site 198094010959 putative DNA binding helix; other site 198094010960 metal binding site 1 [ion binding]; metal-binding site 198094010961 dimer interface [polypeptide binding]; other site 198094010962 structural Zn2+ binding site [ion binding]; other site 198094010963 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094010964 ABC-ATPase subunit interface; other site 198094010965 dimer interface [polypeptide binding]; other site 198094010966 putative PBP binding regions; other site 198094010967 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 198094010968 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198094010969 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094010970 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094010971 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 198094010972 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 198094010973 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 198094010974 AP (apurinic/apyrimidinic) site pocket; other site 198094010975 DNA interaction; other site 198094010976 Metal-binding active site; metal-binding site 198094010977 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198094010978 DEAD-like helicases superfamily; Region: DEXDc; smart00487 198094010979 ATP binding site [chemical binding]; other site 198094010980 Mg++ binding site [ion binding]; other site 198094010981 motif III; other site 198094010982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094010983 nucleotide binding region [chemical binding]; other site 198094010984 ATP-binding site [chemical binding]; other site 198094010985 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 198094010986 Fe-S cluster binding site [ion binding]; other site 198094010987 substrate binding site [chemical binding]; other site 198094010988 catalytic site [active] 198094010989 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 198094010990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 198094010991 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 198094010992 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 198094010993 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 198094010994 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 198094010995 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 198094010996 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 198094010997 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094010998 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198094010999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094011000 DNA binding residues [nucleotide binding] 198094011001 DNA primase; Validated; Region: dnaG; PRK05667 198094011002 CHC2 zinc finger; Region: zf-CHC2; pfam01807 198094011003 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 198094011004 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 198094011005 active site 198094011006 metal binding site [ion binding]; metal-binding site 198094011007 interdomain interaction site; other site 198094011008 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 198094011009 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 198094011010 PEP synthetase regulatory protein; Provisional; Region: PRK05339 198094011011 HTH domain; Region: HTH_11; pfam08279 198094011012 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 198094011013 FOG: CBS domain [General function prediction only]; Region: COG0517 198094011014 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 198094011015 Recombination protein O N terminal; Region: RecO_N; pfam11967 198094011016 Recombination protein O C terminal; Region: RecO_C; pfam02565 198094011017 YqzL-like protein; Region: YqzL; pfam14006 198094011018 GTPase Era; Reviewed; Region: era; PRK00089 198094011019 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 198094011020 G1 box; other site 198094011021 GTP/Mg2+ binding site [chemical binding]; other site 198094011022 Switch I region; other site 198094011023 G2 box; other site 198094011024 Switch II region; other site 198094011025 G3 box; other site 198094011026 G4 box; other site 198094011027 G5 box; other site 198094011028 KH domain; Region: KH_2; pfam07650 198094011029 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 198094011030 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198094011031 active site 198094011032 catalytic motif [active] 198094011033 Zn binding site [ion binding]; other site 198094011034 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 198094011035 trimer interface [polypeptide binding]; other site 198094011036 putative active site [active] 198094011037 Zn binding site [ion binding]; other site 198094011038 metal-binding heat shock protein; Provisional; Region: PRK00016 198094011039 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 198094011040 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 198094011041 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 198094011042 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094011043 Zn2+ binding site [ion binding]; other site 198094011044 Mg2+ binding site [ion binding]; other site 198094011045 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 198094011046 PhoH-like protein; Region: PhoH; pfam02562 198094011047 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 198094011048 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 198094011049 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 198094011050 Yqey-like protein; Region: YqeY; pfam09424 198094011051 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 198094011052 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 198094011053 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 198094011054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094011055 FeS/SAM binding site; other site 198094011056 TRAM domain; Region: TRAM; cl01282 198094011057 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 198094011058 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 198094011059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094011060 S-adenosylmethionine binding site [chemical binding]; other site 198094011061 chaperone protein DnaJ; Provisional; Region: PRK14280 198094011062 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198094011063 HSP70 interaction site [polypeptide binding]; other site 198094011064 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 198094011065 substrate binding site [polypeptide binding]; other site 198094011066 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 198094011067 Zn binding sites [ion binding]; other site 198094011068 dimer interface [polypeptide binding]; other site 198094011069 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 198094011070 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 198094011071 nucleotide binding site [chemical binding]; other site 198094011072 NEF interaction site [polypeptide binding]; other site 198094011073 SBD interface [polypeptide binding]; other site 198094011074 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 198094011075 dimer interface [polypeptide binding]; other site 198094011076 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 198094011077 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 198094011078 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 198094011079 HrcA protein C terminal domain; Region: HrcA; pfam01628 198094011080 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 198094011081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094011082 FeS/SAM binding site; other site 198094011083 HemN C-terminal domain; Region: HemN_C; pfam06969 198094011084 Predicted transcriptional regulators [Transcription]; Region: COG1733 198094011085 dimerization interface [polypeptide binding]; other site 198094011086 putative DNA binding site [nucleotide binding]; other site 198094011087 putative Zn2+ binding site [ion binding]; other site 198094011088 GTP-binding protein LepA; Provisional; Region: PRK05433 198094011089 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 198094011090 G1 box; other site 198094011091 putative GEF interaction site [polypeptide binding]; other site 198094011092 GTP/Mg2+ binding site [chemical binding]; other site 198094011093 Switch I region; other site 198094011094 G2 box; other site 198094011095 G3 box; other site 198094011096 Switch II region; other site 198094011097 G4 box; other site 198094011098 G5 box; other site 198094011099 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 198094011100 Elongation Factor G, domain II; Region: EFG_II; pfam14492 198094011101 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 198094011102 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 198094011103 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 198094011104 germination protease; Provisional; Region: PRK02858 198094011105 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 198094011106 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 198094011107 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 198094011108 YqzM-like protein; Region: YqzM; pfam14141 198094011109 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 198094011110 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 198094011111 Competence protein; Region: Competence; pfam03772 198094011112 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094011113 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 198094011114 catalytic motif [active] 198094011115 Zn binding site [ion binding]; other site 198094011116 SLBB domain; Region: SLBB; pfam10531 198094011117 comEA protein; Region: comE; TIGR01259 198094011118 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 198094011119 late competence protein ComER; Validated; Region: PRK07680 198094011120 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 198094011121 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 198094011122 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 198094011123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094011124 S-adenosylmethionine binding site [chemical binding]; other site 198094011125 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 198094011126 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 198094011127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094011128 Zn2+ binding site [ion binding]; other site 198094011129 Mg2+ binding site [ion binding]; other site 198094011130 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 198094011131 active site 198094011132 (T/H)XGH motif; other site 198094011133 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 198094011134 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 198094011135 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 198094011136 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 198094011137 shikimate binding site; other site 198094011138 NAD(P) binding site [chemical binding]; other site 198094011139 GTPase YqeH; Provisional; Region: PRK13796 198094011140 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 198094011141 GTP/Mg2+ binding site [chemical binding]; other site 198094011142 G4 box; other site 198094011143 G5 box; other site 198094011144 G1 box; other site 198094011145 Switch I region; other site 198094011146 G2 box; other site 198094011147 G3 box; other site 198094011148 Switch II region; other site 198094011149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094011150 active site 198094011151 motif I; other site 198094011152 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 198094011153 motif II; other site 198094011154 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 198094011155 sporulation sigma factor SigK; Reviewed; Region: PRK05803 198094011156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094011157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094011158 DNA binding residues [nucleotide binding] 198094011159 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 198094011160 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 198094011161 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 198094011162 dimer interface [polypeptide binding]; other site 198094011163 FMN binding site [chemical binding]; other site 198094011164 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198094011165 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 198094011166 synthetase active site [active] 198094011167 NTP binding site [chemical binding]; other site 198094011168 metal binding site [ion binding]; metal-binding site 198094011169 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 198094011170 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 198094011171 dimer interface [polypeptide binding]; other site 198094011172 active site 198094011173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094011174 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198094011175 Coenzyme A binding pocket [chemical binding]; other site 198094011176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094011177 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094011178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094011179 Predicted membrane protein [Function unknown]; Region: COG2259 198094011180 CHAT domain; Region: CHAT; cl19248 198094011181 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 198094011182 catalytic core [active] 198094011183 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 198094011184 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 198094011185 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 198094011186 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 198094011187 Subtilase family; Region: Peptidase_S8; pfam00082 198094011188 catalytic triad [active] 198094011189 putative active site [active] 198094011190 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 198094011191 PA/protease or protease-like domain interface [polypeptide binding]; other site 198094011192 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 198094011193 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 198094011194 cofactor binding site; other site 198094011195 metal binding site [ion binding]; metal-binding site 198094011196 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 198094011197 aromatic arch; other site 198094011198 DCoH dimer interaction site [polypeptide binding]; other site 198094011199 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 198094011200 DCoH tetramer interaction site [polypeptide binding]; other site 198094011201 substrate binding site [chemical binding]; other site 198094011202 Predicted membrane protein [Function unknown]; Region: COG2259 198094011203 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 198094011204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094011205 non-specific DNA binding site [nucleotide binding]; other site 198094011206 salt bridge; other site 198094011207 sequence-specific DNA binding site [nucleotide binding]; other site 198094011208 Cupin domain; Region: Cupin_2; pfam07883 198094011209 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 198094011210 dimer interaction site [polypeptide binding]; other site 198094011211 substrate-binding tunnel; other site 198094011212 active site 198094011213 catalytic site [active] 198094011214 substrate binding site [chemical binding]; other site 198094011215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094011216 Coenzyme A binding pocket [chemical binding]; other site 198094011217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094011218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094011219 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198094011220 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198094011221 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198094011222 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198094011223 Walker A/P-loop; other site 198094011224 ATP binding site [chemical binding]; other site 198094011225 Q-loop/lid; other site 198094011226 ABC transporter signature motif; other site 198094011227 Walker B; other site 198094011228 D-loop; other site 198094011229 H-loop/switch region; other site 198094011230 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094011231 ABC-ATPase subunit interface; other site 198094011232 dimer interface [polypeptide binding]; other site 198094011233 putative PBP binding regions; other site 198094011234 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 198094011235 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198094011236 intersubunit interface [polypeptide binding]; other site 198094011237 YrhC-like protein; Region: YrhC; pfam14143 198094011238 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 198094011239 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 198094011240 putative catalytic cysteine [active] 198094011241 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 198094011242 putative active site [active] 198094011243 metal binding site [ion binding]; metal-binding site 198094011244 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198094011245 homodimer interface [polypeptide binding]; other site 198094011246 substrate-cofactor binding pocket; other site 198094011247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094011248 catalytic residue [active] 198094011249 cysteine synthase; Region: PLN02565 198094011250 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198094011251 dimer interface [polypeptide binding]; other site 198094011252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094011253 catalytic residue [active] 198094011254 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 198094011255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094011256 S-adenosylmethionine binding site [chemical binding]; other site 198094011257 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 198094011258 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 198094011259 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 198094011260 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198094011261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198094011262 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 198094011263 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 198094011264 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198094011265 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 198094011266 ATP-binding site [chemical binding]; other site 198094011267 Sugar specificity; other site 198094011268 Pyrimidine base specificity; other site 198094011269 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 198094011270 putative protease; Provisional; Region: PRK15452 198094011271 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 198094011272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094011273 S-adenosylmethionine binding site [chemical binding]; other site 198094011274 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 198094011275 dimerization interface [polypeptide binding]; other site 198094011276 hypothetical protein; Provisional; Region: PRK13678 198094011277 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 198094011278 hypothetical protein; Provisional; Region: PRK05473 198094011279 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 198094011280 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 198094011281 motif 1; other site 198094011282 active site 198094011283 motif 2; other site 198094011284 motif 3; other site 198094011285 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 198094011286 DHHA1 domain; Region: DHHA1; pfam02272 198094011287 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 198094011288 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 198094011289 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 198094011290 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 198094011291 AAA domain; Region: AAA_30; pfam13604 198094011292 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198094011293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094011294 TPR motif; other site 198094011295 TPR repeat; Region: TPR_11; pfam13414 198094011296 binding surface 198094011297 TPR repeat; Region: TPR_11; pfam13414 198094011298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094011299 binding surface 198094011300 TPR motif; other site 198094011301 TPR repeat; Region: TPR_11; pfam13414 198094011302 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 198094011303 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 198094011304 Ligand Binding Site [chemical binding]; other site 198094011305 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 198094011306 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094011307 catalytic residue [active] 198094011308 Predicted transcriptional regulator [Transcription]; Region: COG1959 198094011309 Rrf2 family protein; Region: rrf2_super; TIGR00738 198094011310 recombination factor protein RarA; Reviewed; Region: PRK13342 198094011311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094011312 Walker A motif; other site 198094011313 ATP binding site [chemical binding]; other site 198094011314 Walker B motif; other site 198094011315 arginine finger; other site 198094011316 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 198094011317 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 198094011318 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 198094011319 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 198094011320 putative ATP binding site [chemical binding]; other site 198094011321 putative substrate interface [chemical binding]; other site 198094011322 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 198094011323 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 198094011324 dimer interface [polypeptide binding]; other site 198094011325 anticodon binding site; other site 198094011326 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 198094011327 homodimer interface [polypeptide binding]; other site 198094011328 motif 1; other site 198094011329 active site 198094011330 motif 2; other site 198094011331 GAD domain; Region: GAD; pfam02938 198094011332 motif 3; other site 198094011333 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 198094011334 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 198094011335 dimer interface [polypeptide binding]; other site 198094011336 motif 1; other site 198094011337 active site 198094011338 motif 2; other site 198094011339 motif 3; other site 198094011340 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 198094011341 anticodon binding site; other site 198094011342 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 198094011343 putative active site [active] 198094011344 dimerization interface [polypeptide binding]; other site 198094011345 putative tRNAtyr binding site [nucleotide binding]; other site 198094011346 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 198094011347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094011348 Zn2+ binding site [ion binding]; other site 198094011349 Mg2+ binding site [ion binding]; other site 198094011350 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198094011351 synthetase active site [active] 198094011352 NTP binding site [chemical binding]; other site 198094011353 metal binding site [ion binding]; metal-binding site 198094011354 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 198094011355 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 198094011356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094011357 active site 198094011358 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 198094011359 DHH family; Region: DHH; pfam01368 198094011360 DHHA1 domain; Region: DHHA1; pfam02272 198094011361 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 198094011362 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 198094011363 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 198094011364 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 198094011365 MMPL family; Region: MMPL; cl14618 198094011366 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 198094011367 Protein export membrane protein; Region: SecD_SecF; pfam02355 198094011368 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 198094011369 stage V sporulation protein B; Region: spore_V_B; TIGR02900 198094011370 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 198094011371 Predicted membrane protein [Function unknown]; Region: COG2323 198094011372 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 198094011373 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 198094011374 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 198094011375 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 198094011376 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 198094011377 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 198094011378 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 198094011379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094011380 Walker A motif; other site 198094011381 ATP binding site [chemical binding]; other site 198094011382 Walker B motif; other site 198094011383 arginine finger; other site 198094011384 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 198094011385 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 198094011386 RuvA N terminal domain; Region: RuvA_N; pfam01330 198094011387 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 198094011388 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 198094011389 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198094011390 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 198094011391 putative ligand binding residues [chemical binding]; other site 198094011392 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 198094011393 BofC C-terminal domain; Region: BofC_C; pfam08955 198094011394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094011395 dimerization interface [polypeptide binding]; other site 198094011396 putative DNA binding site [nucleotide binding]; other site 198094011397 putative Zn2+ binding site [ion binding]; other site 198094011398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198094011399 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 198094011400 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198094011401 quinolinate synthetase; Provisional; Region: PRK09375 198094011402 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 198094011403 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 198094011404 dimerization interface [polypeptide binding]; other site 198094011405 active site 198094011406 L-aspartate oxidase; Provisional; Region: PRK08071 198094011407 L-aspartate oxidase; Provisional; Region: PRK06175 198094011408 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198094011409 cysteine desulfurase; Provisional; Region: PRK02948 198094011410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094011411 catalytic residue [active] 198094011412 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 198094011413 HTH domain; Region: HTH_11; pfam08279 198094011414 3H domain; Region: 3H; pfam02829 198094011415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 198094011416 MOSC domain; Region: MOSC; pfam03473 198094011417 3-alpha domain; Region: 3-alpha; pfam03475 198094011418 prephenate dehydratase; Provisional; Region: PRK11898 198094011419 Prephenate dehydratase; Region: PDT; pfam00800 198094011420 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 198094011421 putative L-Phe binding site [chemical binding]; other site 198094011422 FtsX-like permease family; Region: FtsX; pfam02687 198094011423 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094011424 FtsX-like permease family; Region: FtsX; pfam02687 198094011425 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094011426 FtsX-like permease family; Region: FtsX; pfam02687 198094011427 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094011428 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094011429 Walker A/P-loop; other site 198094011430 ATP binding site [chemical binding]; other site 198094011431 Q-loop/lid; other site 198094011432 ABC transporter signature motif; other site 198094011433 Walker B; other site 198094011434 D-loop; other site 198094011435 H-loop/switch region; other site 198094011436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094011437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094011438 active site 198094011439 phosphorylation site [posttranslational modification] 198094011440 intermolecular recognition site; other site 198094011441 dimerization interface [polypeptide binding]; other site 198094011442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094011443 DNA binding site [nucleotide binding] 198094011444 GTPase CgtA; Reviewed; Region: obgE; PRK12297 198094011445 GTP1/OBG; Region: GTP1_OBG; pfam01018 198094011446 Obg GTPase; Region: Obg; cd01898 198094011447 G1 box; other site 198094011448 GTP/Mg2+ binding site [chemical binding]; other site 198094011449 Switch I region; other site 198094011450 G2 box; other site 198094011451 G3 box; other site 198094011452 Switch II region; other site 198094011453 G4 box; other site 198094011454 G5 box; other site 198094011455 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 198094011456 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 198094011457 Sporulation initiation phospho-transferase B, C-terminal; Region: SPOB_ab; pfam14682 198094011458 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 198094011459 hypothetical protein; Provisional; Region: PRK14553 198094011460 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 198094011461 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 198094011462 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 198094011463 homodimer interface [polypeptide binding]; other site 198094011464 oligonucleotide binding site [chemical binding]; other site 198094011465 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 198094011466 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 198094011467 Peptidase family M50; Region: Peptidase_M50; pfam02163 198094011468 active site 198094011469 putative substrate binding region [chemical binding]; other site 198094011470 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 198094011471 Peptidase family M23; Region: Peptidase_M23; pfam01551 198094011472 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 198094011473 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 198094011474 P-loop; other site 198094011475 ADP binding residues [chemical binding]; other site 198094011476 Switch I; other site 198094011477 Switch II; other site 198094011478 septum formation inhibitor; Reviewed; Region: minC; PRK00513 198094011479 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 198094011480 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 198094011481 rod shape-determining protein MreC; Provisional; Region: PRK13922 198094011482 rod shape-determining protein MreB; Provisional; Region: PRK13927 198094011483 MreB and similar proteins; Region: MreB_like; cd10225 198094011484 nucleotide binding site [chemical binding]; other site 198094011485 Mg binding site [ion binding]; other site 198094011486 putative protofilament interaction site [polypeptide binding]; other site 198094011487 RodZ interaction site [polypeptide binding]; other site 198094011488 hypothetical protein; Reviewed; Region: PRK00024 198094011489 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 198094011490 MPN+ (JAMM) motif; other site 198094011491 Zinc-binding site [ion binding]; other site 198094011492 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 198094011493 active site 198094011494 dimer interface [polypeptide binding]; other site 198094011495 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 198094011496 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198094011497 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198094011498 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 198094011499 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 198094011500 active site 198094011501 HIGH motif; other site 198094011502 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198094011503 KMSKS motif; other site 198094011504 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 198094011505 tRNA binding surface [nucleotide binding]; other site 198094011506 anticodon binding site; other site 198094011507 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 198094011508 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 198094011509 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 198094011510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198094011511 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 198094011512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198094011513 inhibitor-cofactor binding pocket; inhibition site 198094011514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094011515 catalytic residue [active] 198094011516 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 198094011517 dimer interface [polypeptide binding]; other site 198094011518 active site 198094011519 Schiff base residues; other site 198094011520 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 198094011521 active site 198094011522 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 198094011523 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 198094011524 domain interfaces; other site 198094011525 active site 198094011526 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 198094011527 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 198094011528 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 198094011529 tRNA; other site 198094011530 putative tRNA binding site [nucleotide binding]; other site 198094011531 putative NADP binding site [chemical binding]; other site 198094011532 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 198094011533 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094011534 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094011535 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 198094011536 Predicted GTPase [General function prediction only]; Region: COG0218 198094011537 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 198094011538 G1 box; other site 198094011539 GTP/Mg2+ binding site [chemical binding]; other site 198094011540 Switch I region; other site 198094011541 G2 box; other site 198094011542 G3 box; other site 198094011543 Switch II region; other site 198094011544 G4 box; other site 198094011545 G5 box; other site 198094011546 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 198094011547 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 198094011548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094011549 Walker A motif; other site 198094011550 ATP binding site [chemical binding]; other site 198094011551 Walker B motif; other site 198094011552 arginine finger; other site 198094011553 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198094011554 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 198094011555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094011556 Walker A motif; other site 198094011557 ATP binding site [chemical binding]; other site 198094011558 Walker B motif; other site 198094011559 arginine finger; other site 198094011560 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198094011561 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 198094011562 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 198094011563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094011564 Walker A motif; other site 198094011565 ATP binding site [chemical binding]; other site 198094011566 Walker B motif; other site 198094011567 arginine finger; other site 198094011568 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198094011569 trigger factor; Provisional; Region: tig; PRK01490 198094011570 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 198094011571 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198094011572 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 198094011573 Bacterial PH domain; Region: bPH_1; pfam08000 198094011574 YvbH-like oligomerization region; Region: YvbH_ext; pfam11724 198094011575 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 198094011576 active site 198094011577 metal binding site [ion binding]; metal-binding site 198094011578 homotetramer interface [polypeptide binding]; other site 198094011579 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 198094011580 active site 198094011581 dimerization interface [polypeptide binding]; other site 198094011582 ribonuclease PH; Reviewed; Region: rph; PRK00173 198094011583 Ribonuclease PH; Region: RNase_PH_bact; cd11362 198094011584 hexamer interface [polypeptide binding]; other site 198094011585 active site 198094011586 Sporulation and spore germination; Region: Germane; pfam10646 198094011587 Spore germination protein [General function prediction only]; Region: COG5401 198094011588 Sporulation and spore germination; Region: Germane; pfam10646 198094011589 glutamate racemase; Provisional; Region: PRK00865 198094011590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094011591 putative substrate translocation pore; other site 198094011592 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198094011593 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 198094011594 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 198094011595 potential catalytic triad [active] 198094011596 conserved cys residue [active] 198094011597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094011598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094011599 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 198094011600 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 198094011601 potential catalytic triad [active] 198094011602 conserved cys residue [active] 198094011603 Gar1/Naf1 RNA binding region; Region: Gar1; cl01285 198094011604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198094011605 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198094011606 DNA binding residues [nucleotide binding] 198094011607 dimerization interface [polypeptide binding]; other site 198094011608 Sulfate transporter family; Region: Sulfate_transp; cl19250 198094011609 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 198094011610 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094011611 EamA-like transporter family; Region: EamA; pfam00892 198094011612 EamA-like transporter family; Region: EamA; pfam00892 198094011613 cytosine deaminase; Provisional; Region: PRK05985 198094011614 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 198094011615 active site 198094011616 cytosine deaminase; Provisional; Region: PRK05985 198094011617 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 198094011618 active site 198094011619 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198094011620 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 198094011621 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198094011622 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198094011623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094011624 dimer interface [polypeptide binding]; other site 198094011625 conserved gate region; other site 198094011626 putative PBP binding loops; other site 198094011627 ABC-ATPase subunit interface; other site 198094011628 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198094011629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094011630 dimer interface [polypeptide binding]; other site 198094011631 conserved gate region; other site 198094011632 putative PBP binding loops; other site 198094011633 ABC-ATPase subunit interface; other site 198094011634 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198094011635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094011636 Walker A/P-loop; other site 198094011637 ATP binding site [chemical binding]; other site 198094011638 Q-loop/lid; other site 198094011639 ABC transporter signature motif; other site 198094011640 Walker B; other site 198094011641 D-loop; other site 198094011642 H-loop/switch region; other site 198094011643 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094011644 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 198094011645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198094011646 Walker A/P-loop; other site 198094011647 ATP binding site [chemical binding]; other site 198094011648 Q-loop/lid; other site 198094011649 ABC transporter signature motif; other site 198094011650 Walker B; other site 198094011651 D-loop; other site 198094011652 H-loop/switch region; other site 198094011653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198094011654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094011655 active site 198094011656 phosphorylation site [posttranslational modification] 198094011657 intermolecular recognition site; other site 198094011658 dimerization interface [polypeptide binding]; other site 198094011659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094011660 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198094011661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094011662 PspC domain; Region: PspC; pfam04024 198094011663 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 198094011664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094011665 non-specific DNA binding site [nucleotide binding]; other site 198094011666 salt bridge; other site 198094011667 sequence-specific DNA binding site [nucleotide binding]; other site 198094011668 Cupin domain; Region: Cupin_2; pfam07883 198094011669 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 198094011670 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 198094011671 amphipathic channel; other site 198094011672 Asn-Pro-Ala signature motifs; other site 198094011673 Predicted transcriptional regulator [Transcription]; Region: COG1959 198094011674 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 198094011675 Acyltransferase family; Region: Acyl_transf_3; cl19154 198094011676 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 198094011677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094011678 Walker A/P-loop; other site 198094011679 ATP binding site [chemical binding]; other site 198094011680 Q-loop/lid; other site 198094011681 ABC transporter signature motif; other site 198094011682 Walker B; other site 198094011683 D-loop; other site 198094011684 H-loop/switch region; other site 198094011685 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 198094011686 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 198094011687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094011688 active site 198094011689 motif I; other site 198094011690 motif II; other site 198094011691 flagellar motor protein MotA; Validated; Region: PRK08124 198094011692 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 198094011693 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 198094011694 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 198094011695 active site 198094011696 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 198094011697 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 198094011698 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198094011699 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 198094011700 L-aspartate oxidase; Provisional; Region: PRK06175 198094011701 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198094011702 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 198094011703 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 198094011704 putative Iron-sulfur protein interface [polypeptide binding]; other site 198094011705 proximal heme binding site [chemical binding]; other site 198094011706 distal heme binding site [chemical binding]; other site 198094011707 putative dimer interface [polypeptide binding]; other site 198094011708 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 198094011709 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 198094011710 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 198094011711 GIY-YIG motif/motif A; other site 198094011712 active site 198094011713 catalytic site [active] 198094011714 putative DNA binding site [nucleotide binding]; other site 198094011715 metal binding site [ion binding]; metal-binding site 198094011716 Cytochrome P450; Region: p450; cl12078 198094011717 UvrB/uvrC motif; Region: UVR; pfam02151 198094011718 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 198094011719 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 198094011720 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198094011721 catalytic residues [active] 198094011722 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 198094011723 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 198094011724 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 198094011725 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 198094011726 Ligand binding site [chemical binding]; other site 198094011727 enoyl-CoA hydratase; Provisional; Region: PRK07658 198094011728 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198094011729 substrate binding site [chemical binding]; other site 198094011730 oxyanion hole (OAH) forming residues; other site 198094011731 trimer interface [polypeptide binding]; other site 198094011732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094011733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094011734 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 198094011735 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 198094011736 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 198094011737 acyl-activating enzyme (AAE) consensus motif; other site 198094011738 putative AMP binding site [chemical binding]; other site 198094011739 putative active site [active] 198094011740 putative CoA binding site [chemical binding]; other site 198094011741 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 198094011742 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 198094011743 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198094011744 siderophore binding site; other site 198094011745 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198094011746 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094011747 ABC-ATPase subunit interface; other site 198094011748 dimer interface [polypeptide binding]; other site 198094011749 putative PBP binding regions; other site 198094011750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094011751 ABC-ATPase subunit interface; other site 198094011752 dimer interface [polypeptide binding]; other site 198094011753 putative PBP binding regions; other site 198094011754 DinB family; Region: DinB; cl17821 198094011755 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 198094011756 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 198094011757 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 198094011758 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 198094011759 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094011760 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 198094011761 Walker A/P-loop; other site 198094011762 ATP binding site [chemical binding]; other site 198094011763 Q-loop/lid; other site 198094011764 ABC transporter signature motif; other site 198094011765 Walker B; other site 198094011766 D-loop; other site 198094011767 H-loop/switch region; other site 198094011768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094011769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094011770 dimer interface [polypeptide binding]; other site 198094011771 phosphorylation site [posttranslational modification] 198094011772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094011773 ATP binding site [chemical binding]; other site 198094011774 Mg2+ binding site [ion binding]; other site 198094011775 G-X-G motif; other site 198094011776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094011777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094011778 active site 198094011779 phosphorylation site [posttranslational modification] 198094011780 intermolecular recognition site; other site 198094011781 dimerization interface [polypeptide binding]; other site 198094011782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094011783 DNA binding site [nucleotide binding] 198094011784 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 198094011785 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 198094011786 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 198094011787 putative RNA binding site [nucleotide binding]; other site 198094011788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198094011789 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 198094011790 TrkA-N domain; Region: TrkA_N; pfam02254 198094011791 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 198094011792 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 198094011793 active site 198094011794 catalytic site [active] 198094011795 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198094011796 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198094011797 Walker A/P-loop; other site 198094011798 ATP binding site [chemical binding]; other site 198094011799 Q-loop/lid; other site 198094011800 ABC transporter signature motif; other site 198094011801 Walker B; other site 198094011802 D-loop; other site 198094011803 H-loop/switch region; other site 198094011804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094011805 ABC-ATPase subunit interface; other site 198094011806 dimer interface [polypeptide binding]; other site 198094011807 putative PBP binding regions; other site 198094011808 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 198094011809 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198094011810 intersubunit interface [polypeptide binding]; other site 198094011811 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094011812 heme-binding site [chemical binding]; other site 198094011813 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094011814 heme-binding site [chemical binding]; other site 198094011815 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094011816 heme-binding site [chemical binding]; other site 198094011817 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094011818 heme-binding site [chemical binding]; other site 198094011819 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094011820 heme-binding site [chemical binding]; other site 198094011821 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094011822 heme-binding site [chemical binding]; other site 198094011823 heme uptake protein IsdC; Region: IsdC; TIGR03656 198094011824 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 198094011825 heme-binding site [chemical binding]; other site 198094011826 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 198094011827 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 198094011828 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 198094011829 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094011830 RNA binding surface [nucleotide binding]; other site 198094011831 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 198094011832 probable active site [active] 198094011833 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 198094011834 MutS domain III; Region: MutS_III; pfam05192 198094011835 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 198094011836 Walker A/P-loop; other site 198094011837 ATP binding site [chemical binding]; other site 198094011838 Q-loop/lid; other site 198094011839 ABC transporter signature motif; other site 198094011840 Walker B; other site 198094011841 D-loop; other site 198094011842 H-loop/switch region; other site 198094011843 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094011844 Smr domain; Region: Smr; pfam01713 198094011845 hypothetical protein; Provisional; Region: PRK08609 198094011846 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 198094011847 active site 198094011848 primer binding site [nucleotide binding]; other site 198094011849 NTP binding site [chemical binding]; other site 198094011850 metal binding triad [ion binding]; metal-binding site 198094011851 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 198094011852 active site 198094011853 Colicin V production protein; Region: Colicin_V; pfam02674 198094011854 cell division protein ZapA; Provisional; Region: PRK14126 198094011855 ribonuclease HIII; Provisional; Region: PRK00996 198094011856 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 198094011857 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 198094011858 RNA/DNA hybrid binding site [nucleotide binding]; other site 198094011859 active site 198094011860 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 198094011861 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 198094011862 putative dimer interface [polypeptide binding]; other site 198094011863 putative anticodon binding site; other site 198094011864 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 198094011865 homodimer interface [polypeptide binding]; other site 198094011866 motif 1; other site 198094011867 motif 2; other site 198094011868 active site 198094011869 motif 3; other site 198094011870 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 198094011871 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 198094011872 putative tRNA-binding site [nucleotide binding]; other site 198094011873 B3/4 domain; Region: B3_4; pfam03483 198094011874 tRNA synthetase B5 domain; Region: B5; smart00874 198094011875 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 198094011876 dimer interface [polypeptide binding]; other site 198094011877 motif 1; other site 198094011878 motif 3; other site 198094011879 motif 2; other site 198094011880 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 198094011881 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 198094011882 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 198094011883 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 198094011884 dimer interface [polypeptide binding]; other site 198094011885 motif 1; other site 198094011886 active site 198094011887 motif 2; other site 198094011888 motif 3; other site 198094011889 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 198094011890 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 198094011891 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198094011892 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 198094011893 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094011894 Zn2+ binding site [ion binding]; other site 198094011895 Mg2+ binding site [ion binding]; other site 198094011896 CAAX protease self-immunity; Region: Abi; pfam02517 198094011897 CAAX protease self-immunity; Region: Abi; pfam02517 198094011898 ComEC family competence protein; Provisional; Region: PRK11539 198094011899 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198094011900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094011901 putative substrate translocation pore; other site 198094011902 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 198094011903 HlyD family secretion protein; Region: HlyD_3; pfam13437 198094011904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094011905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094011906 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 198094011907 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 198094011908 oligomer interface [polypeptide binding]; other site 198094011909 active site 198094011910 metal binding site [ion binding]; metal-binding site 198094011911 dUTPase; Region: dUTPase_2; pfam08761 198094011912 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 198094011913 active site 198094011914 homodimer interface [polypeptide binding]; other site 198094011915 metal binding site [ion binding]; metal-binding site 198094011916 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 198094011917 23S rRNA binding site [nucleotide binding]; other site 198094011918 L21 binding site [polypeptide binding]; other site 198094011919 L13 binding site [polypeptide binding]; other site 198094011920 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 198094011921 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 198094011922 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 198094011923 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 198094011924 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 198094011925 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 198094011926 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 198094011927 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 198094011928 active site 198094011929 dimer interface [polypeptide binding]; other site 198094011930 motif 1; other site 198094011931 motif 2; other site 198094011932 motif 3; other site 198094011933 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 198094011934 anticodon binding site; other site 198094011935 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 198094011936 primosomal protein DnaI; Reviewed; Region: PRK08939 198094011937 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 198094011938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 198094011939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094011940 Walker A motif; other site 198094011941 ATP binding site [chemical binding]; other site 198094011942 Walker B motif; other site 198094011943 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 198094011944 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 198094011945 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 198094011946 ATP cone domain; Region: ATP-cone; pfam03477 198094011947 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 198094011948 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 198094011949 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 198094011950 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198094011951 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 198094011952 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 198094011953 CoA-binding site [chemical binding]; other site 198094011954 ATP-binding [chemical binding]; other site 198094011955 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 198094011956 Domain of unknown function DUF; Region: DUF204; pfam02659 198094011957 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 198094011958 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 198094011959 DNA binding site [nucleotide binding] 198094011960 catalytic residue [active] 198094011961 H2TH interface [polypeptide binding]; other site 198094011962 putative catalytic residues [active] 198094011963 turnover-facilitating residue; other site 198094011964 intercalation triad [nucleotide binding]; other site 198094011965 8OG recognition residue [nucleotide binding]; other site 198094011966 putative reading head residues; other site 198094011967 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 198094011968 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198094011969 DNA polymerase I; Provisional; Region: PRK05755 198094011970 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 198094011971 active site 198094011972 metal binding site 1 [ion binding]; metal-binding site 198094011973 putative 5' ssDNA interaction site; other site 198094011974 metal binding site 3; metal-binding site 198094011975 metal binding site 2 [ion binding]; metal-binding site 198094011976 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 198094011977 putative DNA binding site [nucleotide binding]; other site 198094011978 putative metal binding site [ion binding]; other site 198094011979 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 198094011980 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 198094011981 active site 198094011982 DNA binding site [nucleotide binding] 198094011983 catalytic site [active] 198094011984 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198094011985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094011986 dimerization interface [polypeptide binding]; other site 198094011987 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 198094011988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094011989 putative active site [active] 198094011990 heme pocket [chemical binding]; other site 198094011991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094011992 dimer interface [polypeptide binding]; other site 198094011993 phosphorylation site [posttranslational modification] 198094011994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094011995 ATP binding site [chemical binding]; other site 198094011996 Mg2+ binding site [ion binding]; other site 198094011997 G-X-G motif; other site 198094011998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094011999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094012000 active site 198094012001 phosphorylation site [posttranslational modification] 198094012002 intermolecular recognition site; other site 198094012003 dimerization interface [polypeptide binding]; other site 198094012004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094012005 DNA binding site [nucleotide binding] 198094012006 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 198094012007 active site 2 [active] 198094012008 active site 1 [active] 198094012009 malate dehydrogenase; Reviewed; Region: PRK06223 198094012010 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 198094012011 NAD(P) binding site [chemical binding]; other site 198094012012 dimer interface [polypeptide binding]; other site 198094012013 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198094012014 substrate binding site [chemical binding]; other site 198094012015 isocitrate dehydrogenase; Reviewed; Region: PRK07006 198094012016 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 198094012017 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 198094012018 dimer interface [polypeptide binding]; other site 198094012019 active site 198094012020 citrylCoA binding site [chemical binding]; other site 198094012021 oxalacetate/citrate binding site [chemical binding]; other site 198094012022 coenzyme A binding site [chemical binding]; other site 198094012023 catalytic triad [active] 198094012024 Protein of unknown function (DUF441); Region: DUF441; pfam04284 198094012025 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 198094012026 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 198094012027 pyruvate kinase; Provisional; Region: PRK06354 198094012028 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 198094012029 domain interfaces; other site 198094012030 active site 198094012031 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 198094012032 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 198094012033 active site 198094012034 ADP/pyrophosphate binding site [chemical binding]; other site 198094012035 dimerization interface [polypeptide binding]; other site 198094012036 allosteric effector site; other site 198094012037 fructose-1,6-bisphosphate binding site; other site 198094012038 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 198094012039 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 198094012040 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198094012041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094012042 DNA-binding site [nucleotide binding]; DNA binding site 198094012043 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 198094012044 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198094012045 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 198094012046 putative NAD(P) binding site [chemical binding]; other site 198094012047 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 198094012048 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 198094012049 active site 198094012050 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 198094012051 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 198094012052 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 198094012053 generic binding surface II; other site 198094012054 generic binding surface I; other site 198094012055 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 198094012056 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 198094012057 DHH family; Region: DHH; pfam01368 198094012058 DHHA1 domain; Region: DHHA1; pfam02272 198094012059 YtpI-like protein; Region: YtpI; pfam14007 198094012060 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 198094012061 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 198094012062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 198094012063 DNA-binding site [nucleotide binding]; DNA binding site 198094012064 DRTGG domain; Region: DRTGG; pfam07085 198094012065 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 198094012066 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 198094012067 active site 2 [active] 198094012068 active site 1 [active] 198094012069 metal-dependent hydrolase; Provisional; Region: PRK00685 198094012070 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 198094012071 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 198094012072 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 198094012073 active site 198094012074 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 198094012075 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 198094012076 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198094012077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094012078 Coenzyme A binding pocket [chemical binding]; other site 198094012079 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 198094012080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094012081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094012082 Coenzyme A binding pocket [chemical binding]; other site 198094012083 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 198094012084 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 198094012085 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 198094012086 hexamer interface [polypeptide binding]; other site 198094012087 ligand binding site [chemical binding]; other site 198094012088 putative active site [active] 198094012089 NAD(P) binding site [chemical binding]; other site 198094012090 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 198094012091 classical (c) SDRs; Region: SDR_c; cd05233 198094012092 NAD(P) binding site [chemical binding]; other site 198094012093 active site 198094012094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198094012095 Ligand Binding Site [chemical binding]; other site 198094012096 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 198094012097 argininosuccinate lyase; Provisional; Region: PRK00855 198094012098 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 198094012099 active sites [active] 198094012100 tetramer interface [polypeptide binding]; other site 198094012101 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 198094012102 ANP binding site [chemical binding]; other site 198094012103 Substrate Binding Site II [chemical binding]; other site 198094012104 Substrate Binding Site I [chemical binding]; other site 198094012105 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094012106 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094012107 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094012108 EcsC protein family; Region: EcsC; pfam12787 198094012109 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 198094012110 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 198094012111 nudix motif; other site 198094012112 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 198094012113 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 198094012114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094012115 S-adenosylmethionine binding site [chemical binding]; other site 198094012116 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 198094012117 dimer interface [polypeptide binding]; other site 198094012118 catalytic triad [active] 198094012119 peroxidatic and resolving cysteines [active] 198094012120 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 198094012121 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 198094012122 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 198094012123 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 198094012124 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 198094012125 active site 198094012126 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 198094012127 dimer interface [polypeptide binding]; other site 198094012128 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 198094012129 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198094012130 acyl-activating enzyme (AAE) consensus motif; other site 198094012131 AMP binding site [chemical binding]; other site 198094012132 active site 198094012133 CoA binding site [chemical binding]; other site 198094012134 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 198094012135 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 198094012136 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 198094012137 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 198094012138 Ligand Binding Site [chemical binding]; other site 198094012139 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 198094012140 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094012141 catalytic residue [active] 198094012142 septation ring formation regulator EzrA; Provisional; Region: PRK04778 198094012143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094012144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094012145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198094012146 dimerization interface [polypeptide binding]; other site 198094012147 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094012148 EamA-like transporter family; Region: EamA; pfam00892 198094012149 EamA-like transporter family; Region: EamA; pfam00892 198094012150 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 198094012151 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198094012152 homodimer interface [polypeptide binding]; other site 198094012153 substrate-cofactor binding pocket; other site 198094012154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094012155 catalytic residue [active] 198094012156 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 198094012157 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 198094012158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094012159 RNA binding surface [nucleotide binding]; other site 198094012160 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 198094012161 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 198094012162 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 198094012163 active site 198094012164 HIGH motif; other site 198094012165 dimer interface [polypeptide binding]; other site 198094012166 KMSKS motif; other site 198094012167 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094012168 RNA binding surface [nucleotide binding]; other site 198094012169 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 198094012170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094012171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094012172 DNA binding residues [nucleotide binding] 198094012173 acetyl-CoA synthetase; Provisional; Region: PRK04319 198094012174 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198094012175 acyl-activating enzyme (AAE) consensus motif; other site 198094012176 AMP binding site [chemical binding]; other site 198094012177 active site 198094012178 CoA binding site [chemical binding]; other site 198094012179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094012180 Coenzyme A binding pocket [chemical binding]; other site 198094012181 FOG: CBS domain [General function prediction only]; Region: COG0517 198094012182 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 198094012183 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 198094012184 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 198094012185 active site 198094012186 Zn binding site [ion binding]; other site 198094012187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094012188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094012189 active site 198094012190 phosphorylation site [posttranslational modification] 198094012191 intermolecular recognition site; other site 198094012192 dimerization interface [polypeptide binding]; other site 198094012193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094012194 DNA binding site [nucleotide binding] 198094012195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094012196 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094012197 dimerization interface [polypeptide binding]; other site 198094012198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094012199 dimer interface [polypeptide binding]; other site 198094012200 phosphorylation site [posttranslational modification] 198094012201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094012202 ATP binding site [chemical binding]; other site 198094012203 Mg2+ binding site [ion binding]; other site 198094012204 G-X-G motif; other site 198094012205 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 198094012206 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198094012207 Ankyrin repeat; Region: Ank; pfam00023 198094012208 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198094012209 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198094012210 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 198094012211 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198094012212 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198094012213 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 198094012214 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 198094012215 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 198094012216 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 198094012217 catabolite control protein A; Region: ccpA; TIGR01481 198094012218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094012219 DNA binding site [nucleotide binding] 198094012220 domain linker motif; other site 198094012221 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 198094012222 dimerization interface [polypeptide binding]; other site 198094012223 effector binding site; other site 198094012224 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 198094012225 putative dimer interface [polypeptide binding]; other site 198094012226 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 198094012227 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 198094012228 putative dimer interface [polypeptide binding]; other site 198094012229 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 198094012230 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 198094012231 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 198094012232 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 198094012233 Flavin Reductases; Region: FlaRed; cl00801 198094012234 Bacterial PH domain; Region: bPH_4; pfam06713 198094012235 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094012236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094012237 Coenzyme A binding pocket [chemical binding]; other site 198094012238 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 198094012239 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198094012240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198094012241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198094012242 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 198094012243 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 198094012244 active site 198094012245 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 198094012246 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198094012247 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 198094012248 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 198094012249 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 198094012250 putative tRNA-binding site [nucleotide binding]; other site 198094012251 hypothetical protein; Provisional; Region: PRK13668 198094012252 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198094012253 catalytic residues [active] 198094012254 NTPase; Reviewed; Region: PRK03114 198094012255 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 198094012256 oligomer interface [polypeptide binding]; other site 198094012257 active site 198094012258 metal binding site [ion binding]; metal-binding site 198094012259 Predicted small secreted protein [Function unknown]; Region: COG5584 198094012260 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094012261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094012262 S-adenosylmethionine binding site [chemical binding]; other site 198094012263 YtzH-like protein; Region: YtzH; pfam14165 198094012264 Phosphotransferase enzyme family; Region: APH; pfam01636 198094012265 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 198094012266 active site 198094012267 substrate binding site [chemical binding]; other site 198094012268 ATP binding site [chemical binding]; other site 198094012269 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198094012270 pullulanase, type I; Region: pulA_typeI; TIGR02104 198094012271 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 198094012272 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 198094012273 Ca binding site [ion binding]; other site 198094012274 active site 198094012275 catalytic site [active] 198094012276 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 198094012277 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 198094012278 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198094012279 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198094012280 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 198094012281 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 198094012282 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094012283 RNA binding surface [nucleotide binding]; other site 198094012284 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 198094012285 active site 198094012286 uracil binding [chemical binding]; other site 198094012287 stage V sporulation protein B; Region: spore_V_B; TIGR02900 198094012288 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 198094012289 HI0933-like protein; Region: HI0933_like; pfam03486 198094012290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094012291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094012292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094012293 putative substrate translocation pore; other site 198094012294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094012295 dimerization interface [polypeptide binding]; other site 198094012296 putative DNA binding site [nucleotide binding]; other site 198094012297 putative Zn2+ binding site [ion binding]; other site 198094012298 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 198094012299 putative hydrophobic ligand binding site [chemical binding]; other site 198094012300 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 198094012301 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 198094012302 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 198094012303 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 198094012304 glucose-1-dehydrogenase; Provisional; Region: PRK08936 198094012305 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 198094012306 NAD binding site [chemical binding]; other site 198094012307 homodimer interface [polypeptide binding]; other site 198094012308 active site 198094012309 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 198094012310 Sugar transport protein; Region: Sugar_transport; pfam06800 198094012311 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 198094012312 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 198094012313 MoaE interaction surface [polypeptide binding]; other site 198094012314 MoeB interaction surface [polypeptide binding]; other site 198094012315 thiocarboxylated glycine; other site 198094012316 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 198094012317 MoaE homodimer interface [polypeptide binding]; other site 198094012318 MoaD interaction [polypeptide binding]; other site 198094012319 active site residues [active] 198094012320 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 198094012321 Walker A motif; other site 198094012322 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 198094012323 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 198094012324 dimer interface [polypeptide binding]; other site 198094012325 putative functional site; other site 198094012326 putative MPT binding site; other site 198094012327 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 198094012328 trimer interface [polypeptide binding]; other site 198094012329 dimer interface [polypeptide binding]; other site 198094012330 putative active site [active] 198094012331 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 198094012332 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198094012333 ATP binding site [chemical binding]; other site 198094012334 substrate interface [chemical binding]; other site 198094012335 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 198094012336 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 198094012337 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 198094012338 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198094012339 active site residue [active] 198094012340 homoserine O-acetyltransferase; Provisional; Region: PRK06765 198094012341 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 198094012342 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 198094012343 Spore germination protein; Region: Spore_permease; pfam03845 198094012344 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 198094012345 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 198094012346 putative nucleotide binding site [chemical binding]; other site 198094012347 putative metal binding site [ion binding]; other site 198094012348 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 198094012349 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 198094012350 active site 198094012351 HIGH motif; other site 198094012352 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198094012353 KMSKS motif; other site 198094012354 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 198094012355 tRNA binding surface [nucleotide binding]; other site 198094012356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094012357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094012358 putative substrate translocation pore; other site 198094012359 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 198094012360 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 198094012361 TrkA-C domain; Region: TrkA_C; pfam02080 198094012362 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 198094012363 Int/Topo IB signature motif; other site 198094012364 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094012365 FtsX-like permease family; Region: FtsX; pfam02687 198094012366 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094012367 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094012368 Walker A/P-loop; other site 198094012369 ATP binding site [chemical binding]; other site 198094012370 Q-loop/lid; other site 198094012371 ABC transporter signature motif; other site 198094012372 Walker B; other site 198094012373 D-loop; other site 198094012374 H-loop/switch region; other site 198094012375 Predicted membrane protein [Function unknown]; Region: COG2311 198094012376 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 198094012377 Protein of unknown function (DUF418); Region: DUF418; pfam04235 198094012378 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 198094012379 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 198094012380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094012381 FeS/SAM binding site; other site 198094012382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094012383 S-adenosylmethionine binding site [chemical binding]; other site 198094012384 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094012385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094012386 Walker A/P-loop; other site 198094012387 ATP binding site [chemical binding]; other site 198094012388 Q-loop/lid; other site 198094012389 ABC transporter signature motif; other site 198094012390 Walker B; other site 198094012391 D-loop; other site 198094012392 H-loop/switch region; other site 198094012393 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 198094012394 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 198094012395 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 198094012396 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 198094012397 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 198094012398 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198094012399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094012400 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 198094012401 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 198094012402 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 198094012403 trimer interface [polypeptide binding]; other site 198094012404 putative metal binding site [ion binding]; other site 198094012405 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198094012406 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 198094012407 active site 198094012408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198094012409 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 198094012410 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 198094012411 GTP binding site; other site 198094012412 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 198094012413 MPT binding site; other site 198094012414 trimer interface [polypeptide binding]; other site 198094012415 S-adenosylmethionine synthetase; Validated; Region: PRK05250 198094012416 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 198094012417 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 198094012418 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 198094012419 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 198094012420 active site 198094012421 substrate-binding site [chemical binding]; other site 198094012422 metal-binding site [ion binding] 198094012423 ATP binding site [chemical binding]; other site 198094012424 ATP synthase I chain; Region: ATP_synt_I; pfam03899 198094012425 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094012426 EamA-like transporter family; Region: EamA; pfam00892 198094012427 EamA-like transporter family; Region: EamA; pfam00892 198094012428 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 198094012429 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 198094012430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094012431 ATP binding site [chemical binding]; other site 198094012432 Mg2+ binding site [ion binding]; other site 198094012433 G-X-G motif; other site 198094012434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094012435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094012436 dimer interface [polypeptide binding]; other site 198094012437 phosphorylation site [posttranslational modification] 198094012438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094012439 ATP binding site [chemical binding]; other site 198094012440 Mg2+ binding site [ion binding]; other site 198094012441 G-X-G motif; other site 198094012442 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198094012443 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094012444 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094012445 Secretory lipase; Region: LIP; pfam03583 198094012446 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 198094012447 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 198094012448 NMT1-like family; Region: NMT1_2; pfam13379 198094012449 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198094012450 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198094012451 Walker A/P-loop; other site 198094012452 ATP binding site [chemical binding]; other site 198094012453 Q-loop/lid; other site 198094012454 ABC transporter signature motif; other site 198094012455 Walker B; other site 198094012456 D-loop; other site 198094012457 H-loop/switch region; other site 198094012458 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198094012459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094012460 dimer interface [polypeptide binding]; other site 198094012461 conserved gate region; other site 198094012462 putative PBP binding loops; other site 198094012463 ABC-ATPase subunit interface; other site 198094012464 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 198094012465 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 198094012466 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 198094012467 nudix motif; other site 198094012468 tumor necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 198094012469 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 198094012470 S-ribosylhomocysteinase; Provisional; Region: PRK02260 198094012471 hypothetical protein; Validated; Region: PRK00041 198094012472 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 198094012473 active site clefts [active] 198094012474 zinc binding site [ion binding]; other site 198094012475 dimer interface [polypeptide binding]; other site 198094012476 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 198094012477 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 198094012478 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 198094012479 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 198094012480 S-layer homology domain; Region: SLH; pfam00395 198094012481 S-layer homology domain; Region: SLH; pfam00395 198094012482 S-layer homology domain; Region: SLH; pfam00395 198094012483 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 198094012484 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198094012485 putative active site [active] 198094012486 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094012487 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094012488 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094012489 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 198094012490 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 198094012491 Predicted membrane protein [Function unknown]; Region: COG3766 198094012492 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198094012493 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 198094012494 hypothetical protein; Provisional; Region: PRK12473 198094012495 Virus attachment protein p12 family; Region: P12; pfam12669 198094012496 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 198094012497 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 198094012498 G1 box; other site 198094012499 GTP/Mg2+ binding site [chemical binding]; other site 198094012500 Switch I region; other site 198094012501 G2 box; other site 198094012502 G3 box; other site 198094012503 Switch II region; other site 198094012504 G4 box; other site 198094012505 G5 box; other site 198094012506 Nucleoside recognition; Region: Gate; pfam07670 198094012507 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 198094012508 Nucleoside recognition; Region: Gate; pfam07670 198094012509 FeoA domain; Region: FeoA; pfam04023 198094012510 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 198094012511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 198094012512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094012513 dimerization interface [polypeptide binding]; other site 198094012514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094012515 dimer interface [polypeptide binding]; other site 198094012516 phosphorylation site [posttranslational modification] 198094012517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094012518 ATP binding site [chemical binding]; other site 198094012519 Mg2+ binding site [ion binding]; other site 198094012520 G-X-G motif; other site 198094012521 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094012522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094012523 active site 198094012524 phosphorylation site [posttranslational modification] 198094012525 intermolecular recognition site; other site 198094012526 dimerization interface [polypeptide binding]; other site 198094012527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094012528 DNA binding site [nucleotide binding] 198094012529 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 198094012530 active site 198094012531 catalytic site [active] 198094012532 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 198094012533 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 198094012534 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094012535 active site 198094012536 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 198094012537 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 198094012538 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 198094012539 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 198094012540 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 198094012541 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 198094012542 putative hydrophobic ligand binding site [chemical binding]; other site 198094012543 protein interface [polypeptide binding]; other site 198094012544 gate; other site 198094012545 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094012546 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 198094012547 active site 198094012548 catalytic tetrad [active] 198094012549 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 198094012550 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198094012551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094012552 S-adenosylmethionine binding site [chemical binding]; other site 198094012553 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 198094012554 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094012555 FtsX-like permease family; Region: FtsX; pfam02687 198094012556 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094012557 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094012558 Walker A/P-loop; other site 198094012559 ATP binding site [chemical binding]; other site 198094012560 Q-loop/lid; other site 198094012561 ABC transporter signature motif; other site 198094012562 Walker B; other site 198094012563 D-loop; other site 198094012564 H-loop/switch region; other site 198094012565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094012566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198094012567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198094012568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 198094012569 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094012570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094012571 active site 198094012572 phosphorylation site [posttranslational modification] 198094012573 intermolecular recognition site; other site 198094012574 dimerization interface [polypeptide binding]; other site 198094012575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094012576 DNA binding site [nucleotide binding] 198094012577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094012578 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 198094012579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094012580 ATP binding site [chemical binding]; other site 198094012581 Mg2+ binding site [ion binding]; other site 198094012582 G-X-G motif; other site 198094012583 FtsX-like permease family; Region: FtsX; pfam02687 198094012584 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094012585 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094012586 Walker A/P-loop; other site 198094012587 ATP binding site [chemical binding]; other site 198094012588 Q-loop/lid; other site 198094012589 ABC transporter signature motif; other site 198094012590 Walker B; other site 198094012591 D-loop; other site 198094012592 H-loop/switch region; other site 198094012593 GntP family permease; Region: GntP_permease; pfam02447 198094012594 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 198094012595 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198094012596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198094012597 DNA-binding site [nucleotide binding]; DNA binding site 198094012598 UTRA domain; Region: UTRA; pfam07702 198094012599 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 198094012600 substrate binding site [chemical binding]; other site 198094012601 ATP binding site [chemical binding]; other site 198094012602 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 198094012603 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 198094012604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094012605 catalytic residue [active] 198094012606 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 198094012607 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 198094012608 active site 198094012609 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 198094012610 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 198094012611 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 198094012612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094012613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094012614 dimerization interface [polypeptide binding]; other site 198094012615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094012616 dimer interface [polypeptide binding]; other site 198094012617 phosphorylation site [posttranslational modification] 198094012618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094012619 ATP binding site [chemical binding]; other site 198094012620 Mg2+ binding site [ion binding]; other site 198094012621 G-X-G motif; other site 198094012622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094012623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094012624 active site 198094012625 phosphorylation site [posttranslational modification] 198094012626 intermolecular recognition site; other site 198094012627 dimerization interface [polypeptide binding]; other site 198094012628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094012629 DNA binding site [nucleotide binding] 198094012630 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 198094012631 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 198094012632 active site 198094012633 octamer interface [polypeptide binding]; other site 198094012634 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 198094012635 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 198094012636 acyl-activating enzyme (AAE) consensus motif; other site 198094012637 putative AMP binding site [chemical binding]; other site 198094012638 putative active site [active] 198094012639 putative CoA binding site [chemical binding]; other site 198094012640 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 198094012641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198094012642 substrate binding site [chemical binding]; other site 198094012643 oxyanion hole (OAH) forming residues; other site 198094012644 trimer interface [polypeptide binding]; other site 198094012645 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 198094012646 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094012647 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 198094012648 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 198094012649 dimer interface [polypeptide binding]; other site 198094012650 tetramer interface [polypeptide binding]; other site 198094012651 PYR/PP interface [polypeptide binding]; other site 198094012652 TPP binding site [chemical binding]; other site 198094012653 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198094012654 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 198094012655 TPP-binding site; other site 198094012656 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 198094012657 chorismate binding enzyme; Region: Chorismate_bind; cl10555 198094012658 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 198094012659 putative active site [active] 198094012660 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 198094012661 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198094012662 DNA-binding site [nucleotide binding]; DNA binding site 198094012663 RNA-binding motif; other site 198094012664 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 198094012665 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 198094012666 active site flap/lid [active] 198094012667 nucleophilic elbow; other site 198094012668 catalytic triad [active] 198094012669 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 198094012670 homodimer interface [polypeptide binding]; other site 198094012671 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 198094012672 active site pocket [active] 198094012673 glycogen synthase; Provisional; Region: glgA; PRK00654 198094012674 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 198094012675 ADP-binding pocket [chemical binding]; other site 198094012676 homodimer interface [polypeptide binding]; other site 198094012677 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 198094012678 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 198094012679 ligand binding site; other site 198094012680 oligomer interface; other site 198094012681 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 198094012682 dimer interface [polypeptide binding]; other site 198094012683 N-terminal domain interface [polypeptide binding]; other site 198094012684 sulfate 1 binding site; other site 198094012685 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 198094012686 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 198094012687 ligand binding site; other site 198094012688 oligomer interface; other site 198094012689 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 198094012690 dimer interface [polypeptide binding]; other site 198094012691 N-terminal domain interface [polypeptide binding]; other site 198094012692 sulfate 1 binding site; other site 198094012693 glycogen branching enzyme; Provisional; Region: PRK12313 198094012694 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 198094012695 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 198094012696 active site 198094012697 catalytic site [active] 198094012698 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 198094012699 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 198094012700 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 198094012701 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198094012702 NAD binding site [chemical binding]; other site 198094012703 dimer interface [polypeptide binding]; other site 198094012704 substrate binding site [chemical binding]; other site 198094012705 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 198094012706 MgtC family; Region: MgtC; pfam02308 198094012707 Ion channel; Region: Ion_trans_2; pfam07885 198094012708 TrkA-N domain; Region: TrkA_N; pfam02254 198094012709 YugN-like family; Region: YugN; pfam08868 198094012710 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 198094012711 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 198094012712 active site 198094012713 dimer interface [polypeptide binding]; other site 198094012714 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 198094012715 dimer interface [polypeptide binding]; other site 198094012716 active site 198094012717 Domain of unknown function (DUF378); Region: DUF378; pfam04070 198094012718 general stress protein 13; Validated; Region: PRK08059 198094012719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 198094012720 RNA binding site [nucleotide binding]; other site 198094012721 aspartate aminotransferase; Provisional; Region: PRK05764 198094012722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094012723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094012724 homodimer interface [polypeptide binding]; other site 198094012725 catalytic residue [active] 198094012726 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198094012727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 198094012728 AsnC family; Region: AsnC_trans_reg; pfam01037 198094012729 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 198094012730 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 198094012731 dimerization interface [polypeptide binding]; other site 198094012732 ligand binding site [chemical binding]; other site 198094012733 NADP binding site [chemical binding]; other site 198094012734 catalytic site [active] 198094012735 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094012736 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198094012737 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198094012738 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 198094012739 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 198094012740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198094012741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094012742 homodimer interface [polypeptide binding]; other site 198094012743 catalytic residue [active] 198094012744 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 198094012745 E-class dimer interface [polypeptide binding]; other site 198094012746 P-class dimer interface [polypeptide binding]; other site 198094012747 active site 198094012748 Cu2+ binding site [ion binding]; other site 198094012749 Zn2+ binding site [ion binding]; other site 198094012750 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 198094012751 Kinase associated protein B; Region: KapB; pfam08810 198094012752 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 198094012753 active site 198094012754 catalytic site [active] 198094012755 substrate binding site [chemical binding]; other site 198094012756 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198094012757 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 198094012758 transmembrane helices; other site 198094012759 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 198094012760 active site 198094012761 glycyl-tRNA synthetase; Provisional; Region: PRK04173 198094012762 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 198094012763 dimer interface [polypeptide binding]; other site 198094012764 motif 1; other site 198094012765 active site 198094012766 motif 2; other site 198094012767 motif 3; other site 198094012768 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 198094012769 anticodon binding site; other site 198094012770 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198094012771 CoenzymeA binding site [chemical binding]; other site 198094012772 subunit interaction site [polypeptide binding]; other site 198094012773 PHB binding site; other site 198094012774 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 198094012775 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 198094012776 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 198094012777 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 198094012778 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 198094012779 active site 198094012780 tetramer interface; other site 198094012781 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 198094012782 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 198094012783 active site 198094012784 substrate binding site [chemical binding]; other site 198094012785 metal binding site [ion binding]; metal-binding site 198094012786 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 198094012787 Uncharacterized conserved protein [Function unknown]; Region: COG1624 198094012788 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 198094012789 multifunctional aminopeptidase A; Provisional; Region: PRK00913 198094012790 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 198094012791 interface (dimer of trimers) [polypeptide binding]; other site 198094012792 Substrate-binding/catalytic site; other site 198094012793 Zn-binding sites [ion binding]; other site 198094012794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 198094012795 Putative membrane protein; Region: YuiB; pfam14068 198094012796 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 198094012797 nudix motif; other site 198094012798 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 198094012799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094012800 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 198094012801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094012802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094012803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 198094012804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094012805 H+ Antiporter protein; Region: 2A0121; TIGR00900 198094012806 putative substrate translocation pore; other site 198094012807 Helix-turn-helix domain; Region: HTH_36; pfam13730 198094012808 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198094012809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 198094012810 putative DNA binding site [nucleotide binding]; other site 198094012811 dimerization interface [polypeptide binding]; other site 198094012812 Protein of unknown function (DUF523); Region: DUF523; pfam04463 198094012813 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 198094012814 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198094012815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094012816 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 198094012817 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 198094012818 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 198094012819 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 198094012820 hypothetical protein; Provisional; Region: PRK13669 198094012821 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 198094012822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094012823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094012824 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 198094012825 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094012826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094012827 Walker A/P-loop; other site 198094012828 ATP binding site [chemical binding]; other site 198094012829 Q-loop/lid; other site 198094012830 ABC transporter signature motif; other site 198094012831 Walker B; other site 198094012832 D-loop; other site 198094012833 H-loop/switch region; other site 198094012834 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 198094012835 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 198094012836 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 198094012837 PhnA protein; Region: PhnA; pfam03831 198094012838 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 198094012839 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 198094012840 PQQ-like domain; Region: PQQ_2; pfam13360 198094012841 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 198094012842 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 198094012843 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 198094012844 CAAX protease self-immunity; Region: Abi; pfam02517 198094012845 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 198094012846 active site 198094012847 NTP binding site [chemical binding]; other site 198094012848 metal binding triad [ion binding]; metal-binding site 198094012849 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 198094012850 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 198094012851 NifU-like domain; Region: NifU; pfam01106 198094012852 spore coat protein YutH; Region: spore_yutH; TIGR02905 198094012853 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 198094012854 tetramer interfaces [polypeptide binding]; other site 198094012855 binuclear metal-binding site [ion binding]; other site 198094012856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094012857 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094012858 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 198094012859 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 198094012860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094012861 active site 198094012862 motif I; other site 198094012863 motif II; other site 198094012864 Predicted transcriptional regulator [Transcription]; Region: COG2345 198094012865 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094012866 putative Zn2+ binding site [ion binding]; other site 198094012867 putative DNA binding site [nucleotide binding]; other site 198094012868 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 198094012869 Uncharacterized conserved protein [Function unknown]; Region: COG2445 198094012870 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 198094012871 putative active site [active] 198094012872 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 198094012873 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 198094012874 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 198094012875 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094012876 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 198094012877 DNA binding residues [nucleotide binding] 198094012878 dimer interface [polypeptide binding]; other site 198094012879 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 198094012880 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 198094012881 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198094012882 catalytic core [active] 198094012883 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 198094012884 putative deacylase active site [active] 198094012885 lipoyl synthase; Provisional; Region: PRK05481 198094012886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094012887 FeS/SAM binding site; other site 198094012888 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 198094012889 Peptidase family M23; Region: Peptidase_M23; pfam01551 198094012890 sporulation protein YunB; Region: spo_yunB; TIGR02832 198094012891 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 198094012892 Transcriptional regulator PadR-like family; Region: PadR; cl17335 198094012893 VanZ like family; Region: VanZ; pfam04892 198094012894 FeS assembly protein SufB; Region: sufB; TIGR01980 198094012895 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 198094012896 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 198094012897 trimerization site [polypeptide binding]; other site 198094012898 active site 198094012899 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 198094012900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198094012901 catalytic residue [active] 198094012902 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 198094012903 FeS assembly protein SufD; Region: sufD; TIGR01981 198094012904 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 198094012905 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 198094012906 Walker A/P-loop; other site 198094012907 ATP binding site [chemical binding]; other site 198094012908 Q-loop/lid; other site 198094012909 ABC transporter signature motif; other site 198094012910 Walker B; other site 198094012911 D-loop; other site 198094012912 H-loop/switch region; other site 198094012913 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 198094012914 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 198094012915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198094012916 dimer interface [polypeptide binding]; other site 198094012917 conserved gate region; other site 198094012918 putative PBP binding loops; other site 198094012919 ABC-ATPase subunit interface; other site 198094012920 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 198094012921 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 198094012922 Walker A/P-loop; other site 198094012923 ATP binding site [chemical binding]; other site 198094012924 Q-loop/lid; other site 198094012925 ABC transporter signature motif; other site 198094012926 Walker B; other site 198094012927 D-loop; other site 198094012928 H-loop/switch region; other site 198094012929 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 198094012930 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198094012931 catalytic residues [active] 198094012932 Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair]; Region: COG1658 198094012933 active site 198094012934 metal binding site [ion binding]; metal-binding site 198094012935 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 198094012936 lipoyl attachment site [posttranslational modification]; other site 198094012937 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 198094012938 putative ArsC-like catalytic residues; other site 198094012939 putative TRX-like catalytic residues [active] 198094012940 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 198094012941 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 198094012942 active site 198094012943 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 198094012944 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 198094012945 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 198094012946 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198094012947 NAD binding site [chemical binding]; other site 198094012948 dimer interface [polypeptide binding]; other site 198094012949 substrate binding site [chemical binding]; other site 198094012950 Coat F domain; Region: Coat_F; pfam07875 198094012951 CAAX protease self-immunity; Region: Abi; pfam02517 198094012952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094012953 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 198094012954 WHG domain; Region: WHG; pfam13305 198094012955 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198094012956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 198094012957 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 198094012958 active site 198094012959 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 198094012960 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198094012961 dimer interface [polypeptide binding]; other site 198094012962 active site 198094012963 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 198094012964 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 198094012965 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198094012966 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198094012967 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198094012968 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 198094012969 substrate binding site [chemical binding]; other site 198094012970 oxyanion hole (OAH) forming residues; other site 198094012971 YuzL-like protein; Region: YuzL; pfam14115 198094012972 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198094012973 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094012974 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 198094012975 Proline dehydrogenase; Region: Pro_dh; pfam01619 198094012976 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 198094012977 Domain of unknown function DUF77; Region: DUF77; pfam01910 198094012978 Cache domain; Region: Cache_1; pfam02743 198094012979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094012980 dimerization interface [polypeptide binding]; other site 198094012981 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 198094012982 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094012983 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 198094012984 dimer interface [polypeptide binding]; other site 198094012985 putative CheW interface [polypeptide binding]; other site 198094012986 Predicted transcriptional regulators [Transcription]; Region: COG1378 198094012987 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 198094012988 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 198094012989 C-terminal domain interface [polypeptide binding]; other site 198094012990 sugar binding site [chemical binding]; other site 198094012991 TQXA domain; Region: TQXA_dom; TIGR03934 198094012992 Cna protein B-type domain; Region: Cna_B; pfam05738 198094012993 Cna protein B-type domain; Region: Cna_B; pfam05738 198094012994 Cna protein B-type domain; Region: Cna_B; pfam05738 198094012995 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198094012996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094012997 putative substrate translocation pore; other site 198094012998 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 198094012999 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198094013000 MAEBL; Provisional; Region: PTZ00121 198094013001 OxaA-like protein precursor; Validated; Region: PRK01622 198094013002 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198094013003 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094013004 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094013005 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 198094013006 hypothetical protein; Provisional; Region: PRK06758 198094013007 Protein of unknown function (DUF3985); Region: DUF3985; pfam13153 198094013008 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 198094013009 active site 198094013010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094013011 non-specific DNA binding site [nucleotide binding]; other site 198094013012 salt bridge; other site 198094013013 sequence-specific DNA binding site [nucleotide binding]; other site 198094013014 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198094013015 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 198094013016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 198094013017 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198094013018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094013019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094013020 active site 198094013021 phosphorylation site [posttranslational modification] 198094013022 intermolecular recognition site; other site 198094013023 dimerization interface [polypeptide binding]; other site 198094013024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094013025 DNA binding site [nucleotide binding] 198094013026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198094013027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094013028 dimer interface [polypeptide binding]; other site 198094013029 phosphorylation site [posttranslational modification] 198094013030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094013031 ATP binding site [chemical binding]; other site 198094013032 Mg2+ binding site [ion binding]; other site 198094013033 G-X-G motif; other site 198094013034 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198094013035 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 198094013036 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 198094013037 active site 198094013038 HIGH motif; other site 198094013039 KMSKS motif; other site 198094013040 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 198094013041 tRNA binding surface [nucleotide binding]; other site 198094013042 anticodon binding site; other site 198094013043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094013044 S-adenosylmethionine binding site [chemical binding]; other site 198094013045 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198094013046 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094013047 dimerization interface [polypeptide binding]; other site 198094013048 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 198094013049 dimer interface [polypeptide binding]; other site 198094013050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198094013051 dimer interface [polypeptide binding]; other site 198094013052 putative CheW interface [polypeptide binding]; other site 198094013053 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 198094013054 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 198094013055 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 198094013056 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 198094013057 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 198094013058 active site 198094013059 Zn binding site [ion binding]; other site 198094013060 Pirin-related protein [General function prediction only]; Region: COG1741 198094013061 Pirin; Region: Pirin; pfam02678 198094013062 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 198094013063 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198094013064 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198094013065 putative Zn2+ binding site [ion binding]; other site 198094013066 putative DNA binding site [nucleotide binding]; other site 198094013067 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 198094013068 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 198094013069 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 198094013070 TrkA-C domain; Region: TrkA_C; pfam02080 198094013071 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 198094013072 Ferritin-like domain; Region: Ferritin; pfam00210 198094013073 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 198094013074 dimerization interface [polypeptide binding]; other site 198094013075 DPS ferroxidase diiron center [ion binding]; other site 198094013076 ion pore; other site 198094013077 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 198094013078 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 198094013079 metal binding site [ion binding]; metal-binding site 198094013080 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 198094013081 Ferritin-like domain; Region: Ferritin; pfam00210 198094013082 ferroxidase diiron center [ion binding]; other site 198094013083 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198094013084 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198094013085 Nucleoside recognition; Region: Gate; pfam07670 198094013086 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198094013087 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198094013088 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198094013089 Nucleoside recognition; Region: Gate; pfam07670 198094013090 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198094013091 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 198094013092 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 198094013093 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 198094013094 NAD binding site [chemical binding]; other site 198094013095 substrate binding site [chemical binding]; other site 198094013096 putative active site [active] 198094013097 TQXA domain; Region: TQXA_dom; TIGR03934 198094013098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198094013099 active site 198094013100 catalytic tetrad [active] 198094013101 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198094013102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094013103 putative substrate translocation pore; other site 198094013104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094013105 dimerization interface [polypeptide binding]; other site 198094013106 putative DNA binding site [nucleotide binding]; other site 198094013107 putative Zn2+ binding site [ion binding]; other site 198094013108 Uncharacterized conserved protein [Function unknown]; Region: COG2427 198094013109 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 198094013110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094013111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094013112 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 198094013113 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 198094013114 active site 198094013115 HIGH motif; other site 198094013116 dimer interface [polypeptide binding]; other site 198094013117 KMSKS motif; other site 198094013118 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198094013119 RNA binding surface [nucleotide binding]; other site 198094013120 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 198094013121 FAD binding domain; Region: FAD_binding_4; pfam01565 198094013122 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 198094013123 SET domain; Region: SET; pfam00856 198094013124 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 198094013125 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198094013126 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 198094013127 dimer interface [polypeptide binding]; other site 198094013128 putative CheW interface [polypeptide binding]; other site 198094013129 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 198094013130 putative phosphate binding site [ion binding]; other site 198094013131 camphor resistance protein CrcB; Provisional; Region: PRK14219 198094013132 camphor resistance protein CrcB; Provisional; Region: PRK14205 198094013133 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 198094013134 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 198094013135 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198094013136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198094013137 Coenzyme A binding pocket [chemical binding]; other site 198094013138 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 198094013139 Nuclease-related domain; Region: NERD; pfam08378 198094013140 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 198094013141 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198094013142 Walker A/P-loop; other site 198094013143 ATP binding site [chemical binding]; other site 198094013144 Q-loop/lid; other site 198094013145 ABC transporter signature motif; other site 198094013146 Walker B; other site 198094013147 D-loop; other site 198094013148 H-loop/switch region; other site 198094013149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094013150 ABC-ATPase subunit interface; other site 198094013151 dimer interface [polypeptide binding]; other site 198094013152 putative PBP binding regions; other site 198094013153 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094013154 ABC-ATPase subunit interface; other site 198094013155 dimer interface [polypeptide binding]; other site 198094013156 putative PBP binding regions; other site 198094013157 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 198094013158 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198094013159 putative ligand binding residues [chemical binding]; other site 198094013160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094013161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094013162 active site 198094013163 phosphorylation site [posttranslational modification] 198094013164 intermolecular recognition site; other site 198094013165 dimerization interface [polypeptide binding]; other site 198094013166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094013167 DNA binding site [nucleotide binding] 198094013168 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 198094013169 SmpB-tmRNA interface; other site 198094013170 ribonuclease R; Region: RNase_R; TIGR02063 198094013171 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198094013172 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198094013173 RNB domain; Region: RNB; pfam00773 198094013174 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 198094013175 RNA binding site [nucleotide binding]; other site 198094013176 Esterase/lipase [General function prediction only]; Region: COG1647 198094013177 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 198094013178 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 198094013179 holin-like protein; Validated; Region: PRK01658 198094013180 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 198094013181 active site 198094013182 NUMOD4 motif; Region: NUMOD4; pfam07463 198094013183 HNH endonuclease; Region: HNH_3; pfam13392 198094013184 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 198094013185 Helix-turn-helix domain; Region: HTH_17; pfam12728 198094013186 Phage Terminase; Region: Terminase_1; cl19862 198094013187 Phage portal protein; Region: Phage_portal; pfam04860 198094013188 Phage capsid family; Region: Phage_capsid; pfam05065 198094013189 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198094013190 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 198094013191 active site 198094013192 DNA binding site [nucleotide binding] 198094013193 Int/Topo IB signature motif; other site 198094013194 enolase; Provisional; Region: eno; PRK00077 198094013195 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 198094013196 dimer interface [polypeptide binding]; other site 198094013197 metal binding site [ion binding]; metal-binding site 198094013198 substrate binding pocket [chemical binding]; other site 198094013199 phosphoglyceromutase; Provisional; Region: PRK05434 198094013200 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 198094013201 substrate binding site [chemical binding]; other site 198094013202 dimer interface [polypeptide binding]; other site 198094013203 catalytic triad [active] 198094013204 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 198094013205 substrate binding site [chemical binding]; other site 198094013206 hinge regions; other site 198094013207 ADP binding site [chemical binding]; other site 198094013208 catalytic site [active] 198094013209 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 198094013210 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 198094013211 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198094013212 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 198094013213 Predicted transcriptional regulator [Transcription]; Region: COG3388 198094013214 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 198094013215 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 198094013216 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 198094013217 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 198094013218 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 198094013219 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 198094013220 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 198094013221 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 198094013222 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 198094013223 stage V sporulation protein AD; Provisional; Region: PRK12404 198094013224 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 198094013225 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 198094013226 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 198094013227 Predicted membrane protein [Function unknown]; Region: COG2323 198094013228 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 198094013229 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 198094013230 oligomer interface [polypeptide binding]; other site 198094013231 active site residues [active] 198094013232 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198094013233 dimerization domain swap beta strand [polypeptide binding]; other site 198094013234 regulatory protein interface [polypeptide binding]; other site 198094013235 active site 198094013236 regulatory phosphorylation site [posttranslational modification]; other site 198094013237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 198094013238 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 198094013239 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 198094013240 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 198094013241 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 198094013242 phosphate binding site [ion binding]; other site 198094013243 putative substrate binding pocket [chemical binding]; other site 198094013244 dimer interface [polypeptide binding]; other site 198094013245 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 198094013246 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 198094013247 putative active site [active] 198094013248 nucleotide binding site [chemical binding]; other site 198094013249 nudix motif; other site 198094013250 putative metal binding site [ion binding]; other site 198094013251 Domain of unknown function (DUF368); Region: DUF368; pfam04018 198094013252 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 198094013253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198094013254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198094013255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094013256 binding surface 198094013257 TPR motif; other site 198094013258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198094013259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198094013260 binding surface 198094013261 Tetratricopeptide repeat; Region: TPR_16; pfam13432 198094013262 TPR motif; other site 198094013263 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 198094013264 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 198094013265 trimer interface [polypeptide binding]; other site 198094013266 active site 198094013267 substrate binding site [chemical binding]; other site 198094013268 CoA binding site [chemical binding]; other site 198094013269 pyrophosphatase PpaX; Provisional; Region: PRK13288 198094013270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094013271 active site 198094013272 motif I; other site 198094013273 motif II; other site 198094013274 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 198094013275 HPr kinase/phosphorylase; Provisional; Region: PRK05428 198094013276 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 198094013277 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 198094013278 Hpr binding site; other site 198094013279 active site 198094013280 homohexamer subunit interaction site [polypeptide binding]; other site 198094013281 Predicted membrane protein [Function unknown]; Region: COG1950 198094013282 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 198094013283 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 198094013284 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 198094013285 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 198094013286 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 198094013287 excinuclease ABC subunit B; Provisional; Region: PRK05298 198094013288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094013289 ATP binding site [chemical binding]; other site 198094013290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094013291 nucleotide binding region [chemical binding]; other site 198094013292 ATP-binding site [chemical binding]; other site 198094013293 Ultra-violet resistance protein B; Region: UvrB; pfam12344 198094013294 UvrB/uvrC motif; Region: UVR; pfam02151 198094013295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 198094013296 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 198094013297 Probable transposase; Region: OrfB_IS605; pfam01385 198094013298 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 198094013299 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 198094013300 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 198094013301 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094013302 DNA binding residues [nucleotide binding] 198094013303 dimer interface [polypeptide binding]; other site 198094013304 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 198094013305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094013306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094013307 non-specific DNA binding site [nucleotide binding]; other site 198094013308 salt bridge; other site 198094013309 sequence-specific DNA binding site [nucleotide binding]; other site 198094013310 Predicted membrane protein [Function unknown]; Region: COG2855 198094013311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094013312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094013313 Retrotransposon hot spot protein; Region: RHSP; cl19421 198094013314 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 198094013315 putative dimerization interface [polypeptide binding]; other site 198094013316 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094013317 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 198094013318 DNA binding residues [nucleotide binding] 198094013319 putative dimer interface [polypeptide binding]; other site 198094013320 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 198094013321 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 198094013322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094013323 ABC transporter; Region: ABC_tran_2; pfam12848 198094013324 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094013325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 198094013326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198094013327 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 198094013328 Walker A/P-loop; other site 198094013329 ATP binding site [chemical binding]; other site 198094013330 Q-loop/lid; other site 198094013331 ABC transporter signature motif; other site 198094013332 Walker B; other site 198094013333 D-loop; other site 198094013334 H-loop/switch region; other site 198094013335 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198094013336 protein binding site [polypeptide binding]; other site 198094013337 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 198094013338 C-terminal peptidase (prc); Region: prc; TIGR00225 198094013339 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 198094013340 protein binding site [polypeptide binding]; other site 198094013341 Catalytic dyad [active] 198094013342 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198094013343 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 198094013344 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 198094013345 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 198094013346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198094013347 Walker A/P-loop; other site 198094013348 ATP binding site [chemical binding]; other site 198094013349 Q-loop/lid; other site 198094013350 ABC transporter signature motif; other site 198094013351 Walker B; other site 198094013352 D-loop; other site 198094013353 H-loop/switch region; other site 198094013354 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 198094013355 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 198094013356 peptide chain release factor 2; Provisional; Region: PRK06746 198094013357 This domain is found in peptide chain release factors; Region: PCRF; smart00937 198094013358 RF-1 domain; Region: RF-1; pfam00472 198094013359 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 198094013360 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 198094013361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094013362 nucleotide binding region [chemical binding]; other site 198094013363 ATP-binding site [chemical binding]; other site 198094013364 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 198094013365 SEC-C motif; Region: SEC-C; cl19389 198094013366 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 198094013367 30S subunit binding site; other site 198094013368 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198094013369 DNA-binding site [nucleotide binding]; DNA binding site 198094013370 RNA-binding motif; other site 198094013371 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 198094013372 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094013373 active site 198094013374 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 198094013375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094013376 ATP binding site [chemical binding]; other site 198094013377 putative Mg++ binding site [ion binding]; other site 198094013378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094013379 nucleotide binding region [chemical binding]; other site 198094013380 ATP-binding site [chemical binding]; other site 198094013381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 198094013382 Sperm tail; Region: NYD-SP28; pfam14772 198094013383 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198094013384 NlpC/P60 family; Region: NLPC_P60; pfam00877 198094013385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198094013386 dimerization interface [polypeptide binding]; other site 198094013387 putative DNA binding site [nucleotide binding]; other site 198094013388 putative Zn2+ binding site [ion binding]; other site 198094013389 EDD domain protein, DegV family; Region: DegV; TIGR00762 198094013390 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 198094013391 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 198094013392 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 198094013393 Transcriptional regulator [Transcription]; Region: LytR; COG1316 198094013394 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 198094013395 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 198094013396 active site 198094013397 homodimer interface [polypeptide binding]; other site 198094013398 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 198094013399 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 198094013400 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 198094013401 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 198094013402 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 198094013403 Mg++ binding site [ion binding]; other site 198094013404 putative catalytic motif [active] 198094013405 substrate binding site [chemical binding]; other site 198094013406 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 198094013407 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 198094013408 NodB motif; other site 198094013409 active site 198094013410 catalytic site [active] 198094013411 Zn binding site [ion binding]; other site 198094013412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198094013413 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198094013414 Walker A motif; other site 198094013415 ATP binding site [chemical binding]; other site 198094013416 Walker B motif; other site 198094013417 arginine finger; other site 198094013418 Transcriptional antiterminator [Transcription]; Region: COG3933 198094013419 PRD domain; Region: PRD; pfam00874 198094013420 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198094013421 active pocket/dimerization site; other site 198094013422 active site 198094013423 phosphorylation site [posttranslational modification] 198094013424 PRD domain; Region: PRD; pfam00874 198094013425 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 198094013426 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 198094013427 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 198094013428 Chromate transporter; Region: Chromate_transp; pfam02417 198094013429 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 198094013430 putative active site [active] 198094013431 YdjC motif; other site 198094013432 Mg binding site [ion binding]; other site 198094013433 putative homodimer interface [polypeptide binding]; other site 198094013434 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 198094013435 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 198094013436 NAD binding site [chemical binding]; other site 198094013437 sugar binding site [chemical binding]; other site 198094013438 divalent metal binding site [ion binding]; other site 198094013439 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198094013440 dimer interface [polypeptide binding]; other site 198094013441 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 198094013442 active site 198094013443 methionine cluster; other site 198094013444 phosphorylation site [posttranslational modification] 198094013445 metal binding site [ion binding]; metal-binding site 198094013446 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 198094013447 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 198094013448 active site 198094013449 P-loop; other site 198094013450 phosphorylation site [posttranslational modification] 198094013451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094013452 S-adenosylmethionine binding site [chemical binding]; other site 198094013453 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 198094013454 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 198094013455 methionine cluster; other site 198094013456 active site 198094013457 phosphorylation site [posttranslational modification] 198094013458 metal binding site [ion binding]; metal-binding site 198094013459 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 198094013460 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 198094013461 active site 198094013462 P-loop; other site 198094013463 phosphorylation site [posttranslational modification] 198094013464 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 198094013465 Acyltransferase family; Region: Acyl_transf_3; pfam01757 198094013466 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 198094013467 Predicted membrane protein [Function unknown]; Region: COG1511 198094013468 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 198094013469 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 198094013470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198094013471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198094013472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198094013473 dimerization interface [polypeptide binding]; other site 198094013474 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 198094013475 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 198094013476 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 198094013477 transmembrane helices; other site 198094013478 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 198094013479 ThiC-associated domain; Region: ThiC-associated; pfam13667 198094013480 ThiC family; Region: ThiC; pfam01964 198094013481 L-lactate permease; Region: Lactate_perm; cl00701 198094013482 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 198094013483 Uncharacterized conserved protein [Function unknown]; Region: COG3339 198094013484 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 198094013485 Sulfatase; Region: Sulfatase; pfam00884 198094013486 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 198094013487 homodimer interface [polypeptide binding]; other site 198094013488 substrate-cofactor binding pocket; other site 198094013489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094013490 catalytic residue [active] 198094013491 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198094013492 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198094013493 Nucleoside recognition; Region: Gate; pfam07670 198094013494 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198094013495 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 198094013496 rod shape-determining protein MreC; Region: MreC; cl19252 198094013497 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 198094013498 BCCT family transporter; Region: BCCT; pfam02028 198094013499 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094013500 Bacterial SH3 domain homologues; Region: SH3b; smart00287 198094013501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 198094013502 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 198094013503 Predicted membrane protein [Function unknown]; Region: COG4640 198094013504 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 198094013505 Double zinc ribbon; Region: DZR; pfam12773 198094013506 Double zinc ribbon; Region: DZR; pfam12773 198094013507 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 198094013508 Uncharacterized conserved protein [Function unknown]; Region: COG4715 198094013509 SNF2 Helicase protein; Region: DUF3670; pfam12419 198094013510 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 198094013511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198094013512 ATP binding site [chemical binding]; other site 198094013513 putative Mg++ binding site [ion binding]; other site 198094013514 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 198094013515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094013516 nucleotide binding region [chemical binding]; other site 198094013517 ATP-binding site [chemical binding]; other site 198094013518 Predicted integral membrane protein [Function unknown]; Region: COG5652 198094013519 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 198094013520 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 198094013521 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 198094013522 ComK protein; Region: ComK; cl11560 198094013523 RNA polymerase factor sigma-70; Validated; Region: PRK06759 198094013524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094013525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 198094013526 DNA binding residues [nucleotide binding] 198094013527 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 198094013528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198094013529 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198094013530 FtsX-like permease family; Region: FtsX; pfam02687 198094013531 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198094013532 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198094013533 Walker A/P-loop; other site 198094013534 ATP binding site [chemical binding]; other site 198094013535 Q-loop/lid; other site 198094013536 ABC transporter signature motif; other site 198094013537 Walker B; other site 198094013538 D-loop; other site 198094013539 H-loop/switch region; other site 198094013540 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198094013541 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198094013542 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198094013543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198094013544 non-specific DNA binding site [nucleotide binding]; other site 198094013545 salt bridge; other site 198094013546 sequence-specific DNA binding site [nucleotide binding]; other site 198094013547 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 198094013548 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 198094013549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094013550 putative substrate translocation pore; other site 198094013551 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 198094013552 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 198094013553 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 198094013554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094013555 dimerization interface [polypeptide binding]; other site 198094013556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094013557 dimer interface [polypeptide binding]; other site 198094013558 phosphorylation site [posttranslational modification] 198094013559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094013560 ATP binding site [chemical binding]; other site 198094013561 Mg2+ binding site [ion binding]; other site 198094013562 G-X-G motif; other site 198094013563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094013564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094013565 active site 198094013566 phosphorylation site [posttranslational modification] 198094013567 intermolecular recognition site; other site 198094013568 dimerization interface [polypeptide binding]; other site 198094013569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094013570 DNA binding site [nucleotide binding] 198094013571 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 198094013572 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 198094013573 NAD binding site [chemical binding]; other site 198094013574 homodimer interface [polypeptide binding]; other site 198094013575 active site 198094013576 substrate binding site [chemical binding]; other site 198094013577 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 198094013578 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 198094013579 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 198094013580 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 198094013581 active site 198094013582 homodimer interface [polypeptide binding]; other site 198094013583 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 198094013584 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 198094013585 Walker A/P-loop; other site 198094013586 ATP binding site [chemical binding]; other site 198094013587 Q-loop/lid; other site 198094013588 ABC transporter signature motif; other site 198094013589 Walker B; other site 198094013590 D-loop; other site 198094013591 H-loop/switch region; other site 198094013592 Bacterial SH3 domain; Region: SH3_3; pfam08239 198094013593 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 198094013594 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198094013595 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 198094013596 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 198094013597 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 198094013598 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 198094013599 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 198094013600 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 198094013601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 198094013602 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 198094013603 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 198094013604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198094013605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198094013606 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 198094013607 rod shape-determining protein Mbl; Provisional; Region: PRK13928 198094013608 MreB and similar proteins; Region: MreB_like; cd10225 198094013609 nucleotide binding site [chemical binding]; other site 198094013610 Mg binding site [ion binding]; other site 198094013611 putative protofilament interaction site [polypeptide binding]; other site 198094013612 RodZ interaction site [polypeptide binding]; other site 198094013613 sporulation transcriptional regulator SpoIIID; Region: spore_III_D; TIGR02844 198094013614 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 198094013615 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 198094013616 Peptidase family M23; Region: Peptidase_M23; pfam01551 198094013617 ABC-2 type transporter; Region: ABC2_membrane; cl17235 198094013618 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 198094013619 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094013620 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094013621 Walker A/P-loop; other site 198094013622 ATP binding site [chemical binding]; other site 198094013623 Q-loop/lid; other site 198094013624 ABC transporter signature motif; other site 198094013625 Walker B; other site 198094013626 D-loop; other site 198094013627 H-loop/switch region; other site 198094013628 stage II sporulation protein D; Region: spore_II_D; TIGR02870 198094013629 Stage II sporulation protein; Region: SpoIID; pfam08486 198094013630 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 198094013631 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 198094013632 hinge; other site 198094013633 active site 198094013634 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 198094013635 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 198094013636 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 198094013637 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198094013638 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 198094013639 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198094013640 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 198094013641 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 198094013642 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198094013643 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 198094013644 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 198094013645 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 198094013646 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 198094013647 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 198094013648 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 198094013649 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 198094013650 NADH dehydrogenase subunit C; Validated; Region: PRK07735 198094013651 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 198094013652 NADH dehydrogenase subunit B; Validated; Region: PRK06411 198094013653 NADH dehydrogenase subunit A; Validated; Region: PRK07756 198094013654 PAS domain; Region: PAS_9; pfam13426 198094013655 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094013656 putative active site [active] 198094013657 heme pocket [chemical binding]; other site 198094013658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198094013659 metal binding site [ion binding]; metal-binding site 198094013660 active site 198094013661 I-site; other site 198094013662 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198094013663 Protein of unknown function (DUF975); Region: DUF975; cl10504 198094013664 Protein of unknown function (DUF975); Region: DUF975; cl10504 198094013665 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 198094013666 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 198094013667 gamma subunit interface [polypeptide binding]; other site 198094013668 epsilon subunit interface [polypeptide binding]; other site 198094013669 LBP interface [polypeptide binding]; other site 198094013670 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 198094013671 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198094013672 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 198094013673 alpha subunit interaction interface [polypeptide binding]; other site 198094013674 Walker A motif; other site 198094013675 ATP binding site [chemical binding]; other site 198094013676 Walker B motif; other site 198094013677 inhibitor binding site; inhibition site 198094013678 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 198094013679 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 198094013680 core domain interface [polypeptide binding]; other site 198094013681 delta subunit interface [polypeptide binding]; other site 198094013682 epsilon subunit interface [polypeptide binding]; other site 198094013683 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 198094013684 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198094013685 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 198094013686 beta subunit interaction interface [polypeptide binding]; other site 198094013687 Walker A motif; other site 198094013688 ATP binding site [chemical binding]; other site 198094013689 Walker B motif; other site 198094013690 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 198094013691 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 198094013692 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 198094013693 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 198094013694 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 198094013695 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 198094013696 ATP synthase I chain; Region: ATP_synt_I; pfam03899 198094013697 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 198094013698 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 198094013699 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198094013700 active site 198094013701 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 198094013702 dimer interface [polypeptide binding]; other site 198094013703 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 198094013704 active site 198094013705 glycine-pyridoxal phosphate binding site [chemical binding]; other site 198094013706 folate binding site [chemical binding]; other site 198094013707 hypothetical protein; Provisional; Region: PRK13690 198094013708 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 198094013709 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198094013710 active site 198094013711 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 198094013712 HPr interaction site; other site 198094013713 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198094013714 active site 198094013715 phosphorylation site [posttranslational modification] 198094013716 Predicted membrane protein [Function unknown]; Region: COG2259 198094013717 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 198094013718 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 198094013719 Predicted membrane protein [Function unknown]; Region: COG1971 198094013720 Domain of unknown function DUF; Region: DUF204; pfam02659 198094013721 Domain of unknown function DUF; Region: DUF204; pfam02659 198094013722 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 198094013723 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 198094013724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198094013725 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 198094013726 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 198094013727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094013728 S-adenosylmethionine binding site [chemical binding]; other site 198094013729 peptide chain release factor 1; Validated; Region: prfA; PRK00591 198094013730 This domain is found in peptide chain release factors; Region: PCRF; smart00937 198094013731 RF-1 domain; Region: RF-1; pfam00472 198094013732 thymidine kinase; Provisional; Region: PRK04296 198094013733 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 198094013734 transcription termination factor Rho; Provisional; Region: rho; PRK09376 198094013735 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 198094013736 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 198094013737 RNA binding site [nucleotide binding]; other site 198094013738 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 198094013739 multimer interface [polypeptide binding]; other site 198094013740 Walker A motif; other site 198094013741 ATP binding site [chemical binding]; other site 198094013742 Walker B motif; other site 198094013743 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 198094013744 putative active site [active] 198094013745 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 198094013746 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 198094013747 hinge; other site 198094013748 active site 198094013749 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 198094013750 intersubunit interface [polypeptide binding]; other site 198094013751 active site 198094013752 zinc binding site [ion binding]; other site 198094013753 Na+ binding site [ion binding]; other site 198094013754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094013755 active site 198094013756 phosphorylation site [posttranslational modification] 198094013757 intermolecular recognition site; other site 198094013758 dimerization interface [polypeptide binding]; other site 198094013759 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 198094013760 CTP synthetase; Validated; Region: pyrG; PRK05380 198094013761 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 198094013762 Catalytic site [active] 198094013763 active site 198094013764 UTP binding site [chemical binding]; other site 198094013765 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 198094013766 active site 198094013767 putative oxyanion hole; other site 198094013768 catalytic triad [active] 198094013769 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 198094013770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094013771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094013772 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 198094013773 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 198094013774 FAD binding site [chemical binding]; other site 198094013775 homotetramer interface [polypeptide binding]; other site 198094013776 substrate binding pocket [chemical binding]; other site 198094013777 catalytic base [active] 198094013778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 198094013779 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 198094013780 FAD binding site [chemical binding]; other site 198094013781 homotetramer interface [polypeptide binding]; other site 198094013782 substrate binding pocket [chemical binding]; other site 198094013783 catalytic base [active] 198094013784 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 198094013785 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 198094013786 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198094013787 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 198094013788 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198094013789 dimer interface [polypeptide binding]; other site 198094013790 active site 198094013791 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198094013792 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198094013793 Cysteine-rich domain; Region: CCG; pfam02754 198094013794 Cysteine-rich domain; Region: CCG; pfam02754 198094013795 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 198094013796 PLD-like domain; Region: PLDc_2; pfam13091 198094013797 putative active site [active] 198094013798 catalytic site [active] 198094013799 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 198094013800 PLD-like domain; Region: PLDc_2; pfam13091 198094013801 putative active site [active] 198094013802 catalytic site [active] 198094013803 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 198094013804 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 198094013805 PAS domain S-box; Region: sensory_box; TIGR00229 198094013806 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094013807 putative active site [active] 198094013808 heme pocket [chemical binding]; other site 198094013809 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198094013810 metal binding site [ion binding]; metal-binding site 198094013811 active site 198094013812 I-site; other site 198094013813 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198094013814 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 198094013815 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198094013816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094013817 active site 198094013818 phosphorylation site [posttranslational modification] 198094013819 intermolecular recognition site; other site 198094013820 dimerization interface [polypeptide binding]; other site 198094013821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198094013822 DNA binding residues [nucleotide binding] 198094013823 dimerization interface [polypeptide binding]; other site 198094013824 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 198094013825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 198094013826 Histidine kinase; Region: HisKA_3; pfam07730 198094013827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094013828 ATP binding site [chemical binding]; other site 198094013829 Mg2+ binding site [ion binding]; other site 198094013830 G-X-G motif; other site 198094013831 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198094013832 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094013833 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198094013834 Walker A/P-loop; other site 198094013835 ATP binding site [chemical binding]; other site 198094013836 Q-loop/lid; other site 198094013837 ABC transporter signature motif; other site 198094013838 Walker B; other site 198094013839 D-loop; other site 198094013840 H-loop/switch region; other site 198094013841 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 198094013842 active site 198094013843 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 198094013844 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 198094013845 PA/protease or protease-like domain interface [polypeptide binding]; other site 198094013846 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 198094013847 metal binding site [ion binding]; metal-binding site 198094013848 RNA polymerase sigma factor; Provisional; Region: PRK12522 198094013849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198094013850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198094013851 DNA binding residues [nucleotide binding] 198094013852 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 198094013853 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 198094013854 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 198094013855 active site 198094013856 HIGH motif; other site 198094013857 KMSK motif region; other site 198094013858 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 198094013859 tRNA binding surface [nucleotide binding]; other site 198094013860 anticodon binding site; other site 198094013861 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 198094013862 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 198094013863 putative dimer interface [polypeptide binding]; other site 198094013864 catalytic triad [active] 198094013865 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 198094013866 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 198094013867 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 198094013868 putative active site [active] 198094013869 Mn binding site [ion binding]; other site 198094013870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094013871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094013872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198094013873 putative substrate translocation pore; other site 198094013874 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 198094013875 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 198094013876 DNA binding residues [nucleotide binding] 198094013877 putative dimer interface [polypeptide binding]; other site 198094013878 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 198094013879 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 198094013880 active site 198094013881 catalytic site [active] 198094013882 metal binding site [ion binding]; metal-binding site 198094013883 dimer interface [polypeptide binding]; other site 198094013884 Transglycosylase; Region: Transgly; pfam00912 198094013885 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 198094013886 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 198094013887 YwhD family; Region: YwhD; pfam08741 198094013888 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 198094013889 Peptidase family M50; Region: Peptidase_M50; pfam02163 198094013890 active site 198094013891 putative substrate binding region [chemical binding]; other site 198094013892 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 198094013893 active site 1 [active] 198094013894 dimer interface [polypeptide binding]; other site 198094013895 hexamer interface [polypeptide binding]; other site 198094013896 active site 2 [active] 198094013897 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 198094013898 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198094013899 Zn2+ binding site [ion binding]; other site 198094013900 Mg2+ binding site [ion binding]; other site 198094013901 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198094013902 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 198094013903 intersubunit interface [polypeptide binding]; other site 198094013904 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198094013905 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198094013906 Walker A/P-loop; other site 198094013907 ATP binding site [chemical binding]; other site 198094013908 Q-loop/lid; other site 198094013909 ABC transporter signature motif; other site 198094013910 Walker B; other site 198094013911 D-loop; other site 198094013912 H-loop/switch region; other site 198094013913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198094013914 ABC-ATPase subunit interface; other site 198094013915 dimer interface [polypeptide binding]; other site 198094013916 putative PBP binding regions; other site 198094013917 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 198094013918 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 198094013919 hypothetical protein; Provisional; Region: PRK12473 198094013920 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 198094013921 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 198094013922 putative heme peroxidase; Provisional; Region: PRK12276 198094013923 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198094013924 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 198094013925 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 198094013926 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 198094013927 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 198094013928 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 198094013929 Protein of unknown function (DUF423); Region: DUF423; pfam04241 198094013930 Sulfate transporter family; Region: Sulfate_transp; cl19250 198094013931 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 198094013932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094013933 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 198094013934 motif II; other site 198094013935 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198094013936 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 198094013937 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 198094013938 ligand binding site [chemical binding]; other site 198094013939 active site 198094013940 UGI interface [polypeptide binding]; other site 198094013941 catalytic site [active] 198094013942 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 198094013943 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 198094013944 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198094013945 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 198094013946 Walker A/P-loop; other site 198094013947 ATP binding site [chemical binding]; other site 198094013948 Q-loop/lid; other site 198094013949 ABC transporter signature motif; other site 198094013950 Walker B; other site 198094013951 D-loop; other site 198094013952 H-loop/switch region; other site 198094013953 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 198094013954 active site 198094013955 catalytic triad [active] 198094013956 oxyanion hole [active] 198094013957 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198094013958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198094013959 DNA binding site [nucleotide binding] 198094013960 domain linker motif; other site 198094013961 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 198094013962 putative dimerization interface [polypeptide binding]; other site 198094013963 putative ligand binding site [chemical binding]; other site 198094013964 Predicted membrane protein [Function unknown]; Region: COG2364 198094013965 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198094013966 homoserine dehydrogenase; Provisional; Region: PRK06349 198094013967 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198094013968 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198094013969 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 198094013970 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 198094013971 proposed active site lysine [active] 198094013972 conserved cys residue [active] 198094013973 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198094013974 homodimer interface [polypeptide binding]; other site 198094013975 substrate-cofactor binding pocket; other site 198094013976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198094013977 catalytic residue [active] 198094013978 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 198094013979 Cl- selectivity filter; other site 198094013980 Cl- binding residues [ion binding]; other site 198094013981 pore gating glutamate residue; other site 198094013982 dimer interface [polypeptide binding]; other site 198094013983 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 198094013984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198094013985 active site 198094013986 motif I; other site 198094013987 motif II; other site 198094013988 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 198094013989 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198094013990 ligand binding site [chemical binding]; other site 198094013991 flexible hinge region; other site 198094013992 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 198094013993 azoreductase; Provisional; Region: PRK13556 198094013994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198094013995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094013996 active site 198094013997 phosphorylation site [posttranslational modification] 198094013998 intermolecular recognition site; other site 198094013999 dimerization interface [polypeptide binding]; other site 198094014000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198094014001 DNA binding residues [nucleotide binding] 198094014002 dimerization interface [polypeptide binding]; other site 198094014003 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 198094014004 dimer interface [polypeptide binding]; other site 198094014005 substrate binding site [chemical binding]; other site 198094014006 ATP binding site [chemical binding]; other site 198094014007 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198094014008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198094014009 metal binding site [ion binding]; metal-binding site 198094014010 active site 198094014011 I-site; other site 198094014012 Protein of unknown function (DUF466); Region: DUF466; pfam04328 198094014013 carbon starvation protein A; Provisional; Region: PRK15015 198094014014 Carbon starvation protein CstA; Region: CstA; pfam02554 198094014015 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 198094014016 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 198094014017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094014018 active site 198094014019 phosphorylation site [posttranslational modification] 198094014020 intermolecular recognition site; other site 198094014021 dimerization interface [polypeptide binding]; other site 198094014022 LytTr DNA-binding domain; Region: LytTR; pfam04397 198094014023 benzoate transport; Region: 2A0115; TIGR00895 198094014024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094014025 putative substrate translocation pore; other site 198094014026 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 198094014027 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198094014028 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198094014029 Predicted membrane protein [Function unknown]; Region: COG2860 198094014030 UPF0126 domain; Region: UPF0126; pfam03458 198094014031 UPF0126 domain; Region: UPF0126; pfam03458 198094014032 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 198094014033 heme-binding site [chemical binding]; other site 198094014034 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 198094014035 dimer interface [polypeptide binding]; other site 198094014036 putative CheW interface [polypeptide binding]; other site 198094014037 conserved hypothetical integral membrane protein; Region: TIGR03766 198094014038 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 198094014039 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 198094014040 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198094014041 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 198094014042 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 198094014043 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 198094014044 active site 198094014045 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 198094014046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094014047 ABC transporter; Region: ABC_tran_2; pfam12848 198094014048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198094014049 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 198094014050 GtrA-like protein; Region: GtrA; pfam04138 198094014051 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 198094014052 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 198094014053 Ligand binding site; other site 198094014054 Putative Catalytic site; other site 198094014055 DXD motif; other site 198094014056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198094014057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198094014058 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 198094014059 MMPL family; Region: MMPL; cl14618 198094014060 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 198094014061 MMPL family; Region: MMPL; cl14618 198094014062 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 198094014063 methionine sulfoxide reductase B; Provisional; Region: PRK00222 198094014064 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 198094014065 antiholin-like protein LrgB; Provisional; Region: PRK04288 198094014066 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 198094014067 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 198094014068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094014069 active site 198094014070 phosphorylation site [posttranslational modification] 198094014071 intermolecular recognition site; other site 198094014072 dimerization interface [polypeptide binding]; other site 198094014073 LytTr DNA-binding domain; Region: LytTR; pfam04397 198094014074 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 198094014075 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198094014076 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198094014077 Histidine kinase; Region: His_kinase; pfam06580 198094014078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094014079 ATP binding site [chemical binding]; other site 198094014080 Mg2+ binding site [ion binding]; other site 198094014081 G-X-G motif; other site 198094014082 benzoate transport; Region: 2A0115; TIGR00895 198094014083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198094014084 putative substrate translocation pore; other site 198094014085 BCCT family transporter; Region: BCCT; pfam02028 198094014086 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 198094014087 active site 198094014088 dimer interface [polypeptide binding]; other site 198094014089 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 198094014090 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 198094014091 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 198094014092 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198094014093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198094014094 NAD(P) binding site [chemical binding]; other site 198094014095 active site 198094014096 UreI/AmiS family, subgroup 2. Putative transporters related to proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like_2; cd13429 198094014097 hexamer interface [polypeptide binding]; other site 198094014098 transport channel [chemical binding]; other site 198094014099 constriction site 1 [chemical binding]; other site 198094014100 constriction site 2 [chemical binding]; other site 198094014101 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 198094014102 UDP-glucose 4-epimerase; Region: PLN02240 198094014103 NAD binding site [chemical binding]; other site 198094014104 homodimer interface [polypeptide binding]; other site 198094014105 active site 198094014106 substrate binding site [chemical binding]; other site 198094014107 Haemolysin-III related; Region: HlyIII; cl03831 198094014108 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 198094014109 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 198094014110 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198094014111 ATP binding site [chemical binding]; other site 198094014112 Mg++ binding site [ion binding]; other site 198094014113 motif III; other site 198094014114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198094014115 nucleotide binding region [chemical binding]; other site 198094014116 ATP-binding site [chemical binding]; other site 198094014117 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 198094014118 RNA binding site [nucleotide binding]; other site 198094014119 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 198094014120 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 198094014121 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 198094014122 active site 198094014123 oligoendopeptidase F; Region: pepF; TIGR00181 198094014124 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 198094014125 active site 198094014126 Zn binding site [ion binding]; other site 198094014127 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 198094014128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198094014129 FeS/SAM binding site; other site 198094014130 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 198094014131 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 198094014132 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 198094014133 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 198094014134 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198094014135 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198094014136 protein binding site [polypeptide binding]; other site 198094014137 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 198094014138 YycH protein; Region: YycI; pfam09648 198094014139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 198094014140 YycH protein; Region: YycH; pfam07435 198094014141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 198094014142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198094014143 dimerization interface [polypeptide binding]; other site 198094014144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198094014145 putative active site [active] 198094014146 heme pocket [chemical binding]; other site 198094014147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198094014148 dimer interface [polypeptide binding]; other site 198094014149 phosphorylation site [posttranslational modification] 198094014150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198094014151 ATP binding site [chemical binding]; other site 198094014152 Mg2+ binding site [ion binding]; other site 198094014153 G-X-G motif; other site 198094014154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198094014155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198094014156 active site 198094014157 phosphorylation site [posttranslational modification] 198094014158 intermolecular recognition site; other site 198094014159 dimerization interface [polypeptide binding]; other site 198094014160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198094014161 DNA binding site [nucleotide binding] 198094014162 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 198094014163 GDP-binding site [chemical binding]; other site 198094014164 ACT binding site; other site 198094014165 IMP binding site; other site 198094014166 replicative DNA helicase; Provisional; Region: PRK05748 198094014167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 198094014168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 198094014169 Walker A motif; other site 198094014170 ATP binding site [chemical binding]; other site 198094014171 Walker B motif; other site 198094014172 DNA binding loops [nucleotide binding] 198094014173 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 198094014174 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 198094014175 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 198094014176 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 198094014177 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 198094014178 DHH family; Region: DHH; pfam01368 198094014179 DHHA1 domain; Region: DHHA1; pfam02272 198094014180 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 198094014181 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 198094014182 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 198094014183 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 198094014184 dimer interface [polypeptide binding]; other site 198094014185 ssDNA binding site [nucleotide binding]; other site 198094014186 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198094014187 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 198094014188 GTP-binding protein YchF; Reviewed; Region: PRK09601 198094014189 YchF GTPase; Region: YchF; cd01900 198094014190 G1 box; other site 198094014191 GTP/Mg2+ binding site [chemical binding]; other site 198094014192 Switch I region; other site 198094014193 G2 box; other site 198094014194 Switch II region; other site 198094014195 G3 box; other site 198094014196 G4 box; other site 198094014197 G5 box; other site 198094014198 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 198094014199 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 198094014200 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 198094014201 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198094014202 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 198094014203 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 198094014204 ParB-like nuclease domain; Region: ParB; smart00470 198094014205 KorB domain; Region: KorB; pfam08535 198094014206 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 198094014207 VirC1 protein; Region: VirC1; cl17401 198094014208 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 198094014209 P-loop; other site 198094014210 Magnesium ion binding site [ion binding]; other site 198094014211 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 198094014212 ParB-like nuclease domain; Region: ParBc; pfam02195 198094014213 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 198094014214 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198094014215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198094014216 S-adenosylmethionine binding site [chemical binding]; other site 198094014217 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 198094014218 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 198094014219 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 198094014220 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 198094014221 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 198094014222 trmE is a tRNA modification GTPase; Region: trmE; cd04164 198094014223 G1 box; other site 198094014224 GTP/Mg2+ binding site [chemical binding]; other site 198094014225 Switch I region; other site 198094014226 G2 box; other site 198094014227 Switch II region; other site 198094014228 G3 box; other site 198094014229 G4 box; other site 198094014230 G5 box; other site 198094014231 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 198094014232 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 198094014233 Jag N-terminus; Region: Jag_N; pfam14804 198094014234 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 198094014235 G-X-X-G motif; other site 198094014236 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 198094014237 RxxxH motif; other site 198094014238 OxaA-like protein precursor; Validated; Region: PRK02944 198094014239 ribonuclease P; Reviewed; Region: rnpA; PRK00499 198094014240 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399