-- dump date   	20140618_212245
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
568206000001	Lysozyme-like; Region: Lysozyme_like; pfam13702
568206000002	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
568206000003	NlpC/P60 family; Region: NLPC_P60; pfam00877
568206000004	AAA-like domain; Region: AAA_10; pfam12846
568206000005	K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927
568206000006	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
568206000007	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
568206000008	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568206000009	Walker A motif; other site
568206000010	ATP binding site [chemical binding]; other site
568206000011	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
568206000012	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
568206000013	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
568206000014	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568206000015	Walker A motif; other site
568206000016	ATP binding site [chemical binding]; other site
568206000017	Walker B motif; other site
568206000018	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
568206000019	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
568206000020	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
568206000021	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
568206000022	P-loop; other site
568206000023	Magnesium ion binding site [ion binding]; other site
568206000024	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
568206000025	Magnesium ion binding site [ion binding]; other site
568206000026	S-layer homology domain; Region: SLH; pfam00395
568206000027	S-layer homology domain; Region: SLH; pfam00395
568206000028	S-layer homology domain; Region: SLH; pfam00395
568206000029	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568206000030	active site
568206000031	metal binding site [ion binding]; metal-binding site
568206000032	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
568206000033	potential frameshift: common BLAST hit: gi|217962497|ref|YP_002341069.1| transposase in Marinococcus halophilus
568206000034	Integrase core domain; Region: rve; pfam00665
568206000035	putative transposase OrfB; Reviewed; Region: PHA02517
568206000036	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
568206000037	CAAX protease self-immunity; Region: Abi; pfam02517
568206000038	Uncharacterized conserved protein [Function unknown]; Region: COG1683
568206000039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206000040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206000041	potential frameshift: common BLAST hit: gi|56899913|ref|YP_173286.1| IS231 transposase
568206000042	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
568206000043	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
568206000044	potential frameshift: common BLAST hit: gi|152975800|ref|YP_001375317.1| phosphoesterase PA-phosphatase related
568206000045	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
568206000046	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
568206000047	active site
568206000048	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
568206000049	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
568206000050	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568206000051	Mga helix-turn-helix domain; Region: Mga; pfam05043
568206000052	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568206000053	active site
568206000054	P-loop; other site
568206000055	phosphorylation site [posttranslational modification]
568206000056	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
568206000057	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
568206000058	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
568206000059	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
568206000060	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
568206000061	putative active site [active]
568206000062	putative metal binding site [ion binding]; other site
568206000063	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
568206000064	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
568206000065	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568206000066	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206000067	dimerization interface [polypeptide binding]; other site
568206000068	putative DNA binding site [nucleotide binding]; other site
568206000069	putative Zn2+ binding site [ion binding]; other site
568206000070	potential frameshift: common BLAST hit: gi|217960993|ref|YP_002339561.1| transposase for insertion sequence element D
568206000071	potential frameshift: common BLAST hit: gi|21392741|ref|NP_652820.1| IS231-related, transposase
568206000072	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
568206000073	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568206000074	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206000075	Catalytic site [active]
568206000076	Histidine kinase N terminal; Region: HisK_N; pfam09385
568206000077	potential frameshift: common BLAST hit: gi|225871624|ref|YP_002752982.1| anthrax toxin expression trans-acting positive regulator
568206000078	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
568206000079	Mga helix-turn-helix domain; Region: Mga; pfam05043
568206000080	potential frameshift: common BLAST hit: gi|225871624|ref|YP_002752982.1| anthrax toxin expression trans-acting positive regulator
568206000081	PRD domain; Region: PRD; pfam00874
568206000082	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568206000083	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
568206000084	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
568206000085	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568206000086	Mga helix-turn-helix domain; Region: Mga; pfam05043
568206000087	CAAX protease self-immunity; Region: Abi; pfam02517
568206000088	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206000089	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206000090	peptide binding site [polypeptide binding]; other site
568206000091	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
568206000092	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206000093	DNA binding residues [nucleotide binding]
568206000094	DNA polymerase IV; Reviewed; Region: PRK03103
568206000095	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
568206000096	active site
568206000097	DNA binding site [nucleotide binding]
568206000098	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
568206000099	YolD-like protein; Region: YolD; pfam08863
568206000100	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
568206000101	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
568206000102	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
568206000103	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
568206000104	active site
568206000105	catalytic residues [active]
568206000106	DNA binding site [nucleotide binding]
568206000107	Int/Topo IB signature motif; other site
568206000108	CAAX protease self-immunity; Region: Abi; pfam02517
568206000109	potential frameshift: common BLAST hit: gi|56899941|ref|YP_173315.1| DNA topoisomerase
568206000110	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
568206000111	domain III; other site
568206000112	nucleotide binding site [chemical binding]; other site
568206000113	DNA binding groove [nucleotide binding]
568206000114	catalytic site [active]
568206000115	domain II; other site
568206000116	domain IV; other site
568206000117	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
568206000118	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
568206000119	active site
568206000120	putative interdomain interaction site [polypeptide binding]; other site
568206000121	putative metal-binding site [ion binding]; other site
568206000122	putative nucleotide binding site [chemical binding]; other site
568206000123	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
568206000124	domain I; other site
568206000125	phosphate binding site [ion binding]; other site
568206000126	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
568206000127	Toprim-like; Region: Toprim_2; pfam13155
568206000128	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
568206000129	Nuclease-related domain; Region: NERD; pfam08378
568206000130	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
568206000131	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
568206000132	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
568206000133	putative active site [active]
568206000134	putative NTP binding site [chemical binding]; other site
568206000135	putative nucleic acid binding site [nucleotide binding]; other site
568206000136	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
568206000137	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
568206000138	active site
568206000139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206000140	S-adenosylmethionine binding site [chemical binding]; other site
568206000141	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
568206000142	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206000143	non-specific DNA binding site [nucleotide binding]; other site
568206000144	sequence-specific DNA binding site [nucleotide binding]; other site
568206000145	salt bridge; other site
568206000146	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
568206000147	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
568206000148	active site
568206000149	catalytic residues [active]
568206000150	DNA binding site [nucleotide binding]
568206000151	Int/Topo IB signature motif; other site
568206000152	potential frameshift: common BLAST hit: gi|218848193|ref|YP_002454924.1| phosphoadenosine phosphosulfate reductase family protein
568206000153	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
568206000154	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
568206000155	Ligand Binding Site [chemical binding]; other site
568206000156	HEPN domain; Region: HEPN; pfam05168
568206000157	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
568206000158	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
568206000159	putative active site [active]
568206000160	putative NTP binding site [chemical binding]; other site
568206000161	putative nucleic acid binding site [nucleotide binding]; other site
568206000162	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
568206000163	active site
568206000164	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
568206000165	active site
568206000166	NTP binding site [chemical binding]; other site
568206000167	metal binding triad [ion binding]; metal-binding site
568206000168	antibiotic binding site [chemical binding]; other site
568206000169	Divergent AAA domain; Region: AAA_4; pfam04326
568206000170	30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806
568206000171	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
568206000172	metal binding triad [ion binding]; metal-binding site
568206000173	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
568206000174	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206000175	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206000176	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
568206000177	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
568206000178	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
568206000179	putative acetyltransferase; Provisional; Region: PRK03624
568206000180	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206000181	Coenzyme A binding pocket [chemical binding]; other site
568206000182	Abi-like protein; Region: Abi_2; pfam07751
568206000183	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
568206000184	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206000185	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206000186	non-specific DNA binding site [nucleotide binding]; other site
568206000187	salt bridge; other site
568206000188	sequence-specific DNA binding site [nucleotide binding]; other site
568206000189	Domain of unknown function (DUF373); Region: DUF373; cl12079
568206000190	AAA-like domain; Region: AAA_10; pfam12846
568206000191	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
568206000192	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
568206000193	Replication-relaxation; Region: Replic_Relax; pfam13814
568206000194	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
568206000195	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
568206000196	DNA binding residues [nucleotide binding]
568206000197	Domain of unknown function (DUF4320); Region: DUF4320; pfam14208
568206000198	S-layer homology domain; Region: SLH; pfam00395
568206000199	S-layer homology domain; Region: SLH; pfam00395
568206000200	S-layer homology domain; Region: SLH; pfam00395
568206000201	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
568206000202	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
568206000203	AAA domain; Region: AAA_31; pfam13614
568206000204	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
568206000205	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
568206000206	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568206000207	Walker A motif; other site
568206000208	ATP binding site [chemical binding]; other site
568206000209	Walker B motif; other site
568206000210	WxL domain surface cell wall-binding; Region: WxL; pfam13731
568206000211	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
568206000212	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
568206000213	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
568206000214	active site
568206000215	metal binding site [ion binding]; metal-binding site
568206000216	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
568206000217	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
568206000218	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
568206000219	PrgI family protein; Region: PrgI; pfam12666
568206000220	AAA-like domain; Region: AAA_10; pfam12846
568206000221	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
568206000222	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
568206000223	N-acetyl-D-glucosamine binding site [chemical binding]; other site
568206000224	catalytic residue [active]
568206000225	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206000226	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206000227	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
568206000228	NlpC/P60 family; Region: NLPC_P60; pfam00877
568206000229	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
568206000230	CAAX protease self-immunity; Region: Abi; pfam02517
568206000231	Predicted membrane protein [Function unknown]; Region: COG2311
568206000232	Protein of unknown function (DUF418); Region: DUF418; cl12135
568206000233	Protein of unknown function (DUF418); Region: DUF418; pfam04235
568206000234	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568206000235	catalytic residues [active]
568206000236	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206000237	heme-binding site [chemical binding]; other site
568206000238	S-layer homology domain; Region: SLH; pfam00395
568206000239	S-layer homology domain; Region: SLH; pfam00395
568206000240	S-layer homology domain; Region: SLH; pfam00395
568206000241	Acetokinase family; Region: Acetate_kinase; cl17229
568206000242	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
568206000243	active site
568206000244	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
568206000245	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
568206000246	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206000247	active site
568206000248	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
568206000249	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
568206000250	active site
568206000251	tetramer interface; other site
568206000252	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
568206000253	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
568206000254	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
568206000255	Winged helix-turn helix; Region: HTH_29; pfam13551
568206000256	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
568206000257	HTH-like domain; Region: HTH_21; pfam13276
568206000258	Integrase core domain; Region: rve; pfam00665
568206000259	Integrase core domain; Region: rve; pfam00665
568206000260	Integrase core domain; Region: rve_2; pfam13333
568206000261	Integrase core domain; Region: rve; pfam00665
568206000262	CRISPR/Cas system-associated protein Cas8c; Region: Csp2_I-U; cl11894
568206000263	Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737
568206000264	Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497
568206000265	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206000266	active site
568206000267	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
568206000268	Transposase domain (DUF772); Region: DUF772; pfam05598
568206000269	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
568206000270	HTH domain; Region: HTH_11; cl17392
568206000271	Mga helix-turn-helix domain; Region: Mga; pfam05043
568206000272	PRD domain; Region: PRD; pfam00874
568206000273	PRD domain; Region: PRD; pfam00874
568206000274	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568206000275	Histidine kinase N terminal; Region: HisK_N; pfam09385
568206000276	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
568206000277	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
568206000278	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
568206000279	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
568206000280	catalytic residues [active]
568206000281	catalytic nucleophile [active]
568206000282	Presynaptic Site I dimer interface [polypeptide binding]; other site
568206000283	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
568206000284	Synaptic Flat tetramer interface [polypeptide binding]; other site
568206000285	Synaptic Site I dimer interface [polypeptide binding]; other site
568206000286	DNA binding site [nucleotide binding]
568206000287	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
568206000288	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
568206000289	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
568206000290	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
568206000291	PA14 domain; Region: PA14; pfam07691
568206000292	Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495
568206000293	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206000294	dimerization interface [polypeptide binding]; other site
568206000295	putative DNA binding site [nucleotide binding]; other site
568206000296	putative Zn2+ binding site [ion binding]; other site
568206000297	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
568206000298	Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737
568206000299	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
568206000300	Anthrax toxin lethal factor, middle domain; Region: Anthrax-tox_M; pfam09156
568206000301	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
568206000302	active site
568206000303	conformational flexibility of ligand binding pocket; other site
568206000304	ADP-ribosylating toxin turn-turn motif; other site
568206000305	Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737
568206000306	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
568206000307	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
568206000308	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
568206000309	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
568206000310	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
568206000311	active site
568206000312	Int/Topo IB signature motif; other site
568206000313	DNA binding site [nucleotide binding]
568206000314	Helix-turn-helix domain; Region: HTH_17; pfam12728
568206000315	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
568206000316	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
568206000317	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
568206000318	putative transposase OrfB; Reviewed; Region: PHA02517
568206000319	HTH-like domain; Region: HTH_21; pfam13276
568206000320	Integrase core domain; Region: rve; pfam00665
568206000321	Integrase core domain; Region: rve_3; pfam13683
568206000322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
568206000323	Homeodomain-like domain; Region: HTH_23; cl17451
568206000324	Homeodomain-like domain; Region: HTH_23; cl17451
568206000325	HTH-like domain; Region: HTH_21; pfam13276
568206000326	Integrase core domain; Region: rve; pfam00665
568206000327	Integrase core domain; Region: rve_2; pfam13333
568206000328	YodA lipocalin-like domain; Region: YodA; pfam09223
568206000329	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568206000330	synthetase active site [active]
568206000331	NTP binding site [chemical binding]; other site
568206000332	metal binding site [ion binding]; metal-binding site
568206000333	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
568206000334	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
568206000335	active site
568206000336	DNA binding site [nucleotide binding]
568206000337	Int/Topo IB signature motif; other site
568206000338	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
568206000339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
568206000340	Walker A motif; other site
568206000341	ATP binding site [chemical binding]; other site
568206000342	Walker B motif; other site
568206000343	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
568206000344	TPR motif; other site
568206000345	binding surface
568206000346	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206000347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206000348	TPR motif; other site
568206000349	binding surface
568206000350	bacterial Hfq-like; Region: Hfq; cd01716
568206000351	hexamer interface [polypeptide binding]; other site
568206000352	Sm1 motif; other site
568206000353	RNA binding site [nucleotide binding]; other site
568206000354	Sm2 motif; other site
568206000355	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206000356	dimerization interface [polypeptide binding]; other site
568206000357	putative DNA binding site [nucleotide binding]; other site
568206000358	putative Zn2+ binding site [ion binding]; other site
568206000359	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
568206000360	Staphylococcal nuclease homologues; Region: SNc; smart00318
568206000361	Catalytic site; other site
568206000362	Staphylococcal nuclease homologue; Region: SNase; pfam00565
568206000363	DNA topoisomerase III; Provisional; Region: PRK07726
568206000364	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
568206000365	active site
568206000366	putative interdomain interaction site [polypeptide binding]; other site
568206000367	putative metal-binding site [ion binding]; other site
568206000368	putative nucleotide binding site [chemical binding]; other site
568206000369	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
568206000370	domain I; other site
568206000371	DNA binding groove [nucleotide binding]
568206000372	phosphate binding site [ion binding]; other site
568206000373	domain II; other site
568206000374	domain III; other site
568206000375	nucleotide binding site [chemical binding]; other site
568206000376	catalytic site [active]
568206000377	domain IV; other site
568206000378	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
568206000379	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
568206000380	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
568206000381	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
568206000382	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
568206000383	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
568206000384	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
568206000385	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
568206000386	DnaA N-terminal domain; Region: DnaA_N; pfam11638
568206000387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206000388	Walker A motif; other site
568206000389	ATP binding site [chemical binding]; other site
568206000390	Walker B motif; other site
568206000391	arginine finger; other site
568206000392	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
568206000393	DnaA box-binding interface [nucleotide binding]; other site
568206000394	DNA polymerase III subunit beta; Validated; Region: PRK05643
568206000395	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
568206000396	putative DNA binding surface [nucleotide binding]; other site
568206000397	dimer interface [polypeptide binding]; other site
568206000398	beta-clamp/clamp loader binding surface; other site
568206000399	beta-clamp/translesion DNA polymerase binding surface; other site
568206000400	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
568206000401	recombination protein F; Reviewed; Region: recF; PRK00064
568206000402	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
568206000403	Walker A/P-loop; other site
568206000404	ATP binding site [chemical binding]; other site
568206000405	Q-loop/lid; other site
568206000406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206000407	ABC transporter signature motif; other site
568206000408	Walker B; other site
568206000409	D-loop; other site
568206000410	H-loop/switch region; other site
568206000411	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
568206000412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206000413	Mg2+ binding site [ion binding]; other site
568206000414	G-X-G motif; other site
568206000415	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
568206000416	anchoring element; other site
568206000417	dimer interface [polypeptide binding]; other site
568206000418	ATP binding site [chemical binding]; other site
568206000419	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
568206000420	active site
568206000421	putative metal-binding site [ion binding]; other site
568206000422	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
568206000423	DNA gyrase subunit A; Validated; Region: PRK05560
568206000424	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
568206000425	CAP-like domain; other site
568206000426	active site
568206000427	primary dimer interface [polypeptide binding]; other site
568206000428	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206000429	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206000430	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206000431	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206000432	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206000433	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206000434	YaaC-like Protein; Region: YaaC; pfam14175
568206000435	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
568206000436	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
568206000437	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
568206000438	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
568206000439	active site
568206000440	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
568206000441	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206000442	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
568206000443	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
568206000444	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
568206000445	active site
568206000446	multimer interface [polypeptide binding]; other site
568206000447	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
568206000448	predicted active site [active]
568206000449	catalytic triad [active]
568206000450	seryl-tRNA synthetase; Provisional; Region: PRK05431
568206000451	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
568206000452	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
568206000453	dimer interface [polypeptide binding]; other site
568206000454	active site
568206000455	motif 1; other site
568206000456	motif 2; other site
568206000457	motif 3; other site
568206000458	Domain of unknown function (DUF3797); Region: DUF3797; pfam12677
568206000459	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
568206000460	DNA binding residues [nucleotide binding]
568206000461	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
568206000462	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
568206000463	Substrate-binding site [chemical binding]; other site
568206000464	Substrate specificity [chemical binding]; other site
568206000465	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
568206000466	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
568206000467	Substrate-binding site [chemical binding]; other site
568206000468	Substrate specificity [chemical binding]; other site
568206000469	Isochorismatase family; Region: Isochorismatase; pfam00857
568206000470	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
568206000471	catalytic triad [active]
568206000472	conserved cis-peptide bond; other site
568206000473	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
568206000474	nucleoside/Zn binding site; other site
568206000475	dimer interface [polypeptide binding]; other site
568206000476	catalytic motif [active]
568206000477	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
568206000478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206000479	Walker A motif; other site
568206000480	ATP binding site [chemical binding]; other site
568206000481	Walker B motif; other site
568206000482	arginine finger; other site
568206000483	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
568206000484	hypothetical protein; Validated; Region: PRK00153
568206000485	recombination protein RecR; Reviewed; Region: recR; PRK00076
568206000486	RecR protein; Region: RecR; pfam02132
568206000487	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
568206000488	putative active site [active]
568206000489	putative metal-binding site [ion binding]; other site
568206000490	tetramer interface [polypeptide binding]; other site
568206000491	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
568206000492	pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862
568206000493	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
568206000494	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
568206000495	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
568206000496	homodimer interface [polypeptide binding]; other site
568206000497	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206000498	catalytic residue [active]
568206000499	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
568206000500	thymidylate kinase; Validated; Region: tmk; PRK00698
568206000501	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
568206000502	TMP-binding site; other site
568206000503	ATP-binding site [chemical binding]; other site
568206000504	DNA polymerase III subunit delta'; Validated; Region: PRK08058
568206000505	DNA polymerase III subunit delta'; Validated; Region: PRK08485
568206000506	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
568206000507	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
568206000508	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
568206000509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206000510	S-adenosylmethionine binding site [chemical binding]; other site
568206000511	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
568206000512	GIY-YIG motif/motif A; other site
568206000513	putative active site [active]
568206000514	putative metal binding site [ion binding]; other site
568206000515	Predicted methyltransferases [General function prediction only]; Region: COG0313
568206000516	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
568206000517	putative SAM binding site [chemical binding]; other site
568206000518	putative homodimer interface [polypeptide binding]; other site
568206000519	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
568206000520	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
568206000521	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
568206000522	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
568206000523	active site
568206000524	HIGH motif; other site
568206000525	KMSKS motif; other site
568206000526	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
568206000527	tRNA binding surface [nucleotide binding]; other site
568206000528	anticodon binding site; other site
568206000529	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
568206000530	dimer interface [polypeptide binding]; other site
568206000531	putative tRNA-binding site [nucleotide binding]; other site
568206000532	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
568206000533	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
568206000534	active site
568206000535	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
568206000536	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
568206000537	putative active site [active]
568206000538	putative metal binding site [ion binding]; other site
568206000539	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
568206000540	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
568206000541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206000542	S-adenosylmethionine binding site [chemical binding]; other site
568206000543	sporulation peptidase YabG; Region: spore_yabG; TIGR02855
568206000544	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
568206000545	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
568206000546	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
568206000547	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
568206000548	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
568206000549	pur operon repressor; Provisional; Region: PRK09213
568206000550	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
568206000551	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206000552	active site
568206000553	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
568206000554	homotrimer interaction site [polypeptide binding]; other site
568206000555	putative active site [active]
568206000556	regulatory protein SpoVG; Reviewed; Region: PRK13259
568206000557	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
568206000558	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
568206000559	Substrate binding site; other site
568206000560	Mg++ binding site; other site
568206000561	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
568206000562	active site
568206000563	substrate binding site [chemical binding]; other site
568206000564	CoA binding site [chemical binding]; other site
568206000565	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
568206000566	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
568206000567	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206000568	active site
568206000569	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
568206000570	putative active site [active]
568206000571	catalytic residue [active]
568206000572	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
568206000573	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
568206000574	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
568206000575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206000576	ATP binding site [chemical binding]; other site
568206000577	putative Mg++ binding site [ion binding]; other site
568206000578	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206000579	nucleotide binding region [chemical binding]; other site
568206000580	ATP-binding site [chemical binding]; other site
568206000581	TRCF domain; Region: TRCF; pfam03461
568206000582	stage V sporulation protein T; Region: spore_V_T; TIGR02851
568206000583	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
568206000584	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568206000585	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
568206000586	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
568206000587	putative SAM binding site [chemical binding]; other site
568206000588	putative homodimer interface [polypeptide binding]; other site
568206000589	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
568206000590	homodimer interface [polypeptide binding]; other site
568206000591	metal binding site [ion binding]; metal-binding site
568206000592	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
568206000593	homodimer interface [polypeptide binding]; other site
568206000594	active site
568206000595	putative chemical substrate binding site [chemical binding]; other site
568206000596	metal binding site [ion binding]; metal-binding site
568206000597	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206000598	RNA binding surface [nucleotide binding]; other site
568206000599	sporulation protein YabP; Region: spore_yabP; TIGR02892
568206000600	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
568206000601	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
568206000602	Septum formation initiator; Region: DivIC; pfam04977
568206000603	hypothetical protein; Provisional; Region: PRK08582
568206000604	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
568206000605	RNA binding site [nucleotide binding]; other site
568206000606	stage II sporulation protein E; Region: spore_II_E; TIGR02865
568206000607	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
568206000608	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
568206000609	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
568206000610	Ligand Binding Site [chemical binding]; other site
568206000611	TilS substrate binding domain; Region: TilS; pfam09179
568206000612	TilS substrate C-terminal domain; Region: TilS_C; smart00977
568206000613	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206000614	active site
568206000615	FtsH Extracellular; Region: FtsH_ext; pfam06480
568206000616	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
568206000617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206000618	Walker A motif; other site
568206000619	ATP binding site [chemical binding]; other site
568206000620	Walker B motif; other site
568206000621	arginine finger; other site
568206000622	Peptidase family M41; Region: Peptidase_M41; pfam01434
568206000623	pantothenate kinase; Reviewed; Region: PRK13318
568206000624	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
568206000625	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
568206000626	dimerization interface [polypeptide binding]; other site
568206000627	domain crossover interface; other site
568206000628	redox-dependent activation switch; other site
568206000629	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
568206000630	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
568206000631	dimer interface [polypeptide binding]; other site
568206000632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206000633	catalytic residue [active]
568206000634	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
568206000635	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
568206000636	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
568206000637	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
568206000638	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
568206000639	glutamine binding [chemical binding]; other site
568206000640	catalytic triad [active]
568206000641	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
568206000642	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
568206000643	homodimer interface [polypeptide binding]; other site
568206000644	substrate-cofactor binding pocket; other site
568206000645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206000646	catalytic residue [active]
568206000647	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
568206000648	dihydropteroate synthase; Region: DHPS; TIGR01496
568206000649	substrate binding pocket [chemical binding]; other site
568206000650	dimer interface [polypeptide binding]; other site
568206000651	inhibitor binding site; inhibition site
568206000652	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
568206000653	homooctamer interface [polypeptide binding]; other site
568206000654	active site
568206000655	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
568206000656	catalytic center binding site [active]
568206000657	ATP binding site [chemical binding]; other site
568206000658	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206000659	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206000660	non-specific DNA binding site [nucleotide binding]; other site
568206000661	salt bridge; other site
568206000662	sequence-specific DNA binding site [nucleotide binding]; other site
568206000663	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
568206000664	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
568206000665	FMN binding site [chemical binding]; other site
568206000666	active site
568206000667	catalytic residues [active]
568206000668	substrate binding site [chemical binding]; other site
568206000669	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
568206000670	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
568206000671	dimer interface [polypeptide binding]; other site
568206000672	putative anticodon binding site; other site
568206000673	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
568206000674	motif 1; other site
568206000675	active site
568206000676	motif 2; other site
568206000677	motif 3; other site
568206000678	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
568206000679	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
568206000680	UvrB/uvrC motif; Region: UVR; pfam02151
568206000681	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
568206000682	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
568206000683	ADP binding site [chemical binding]; other site
568206000684	phosphagen binding site; other site
568206000685	substrate specificity loop; other site
568206000686	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
568206000687	Clp amino terminal domain; Region: Clp_N; pfam02861
568206000688	Clp amino terminal domain; Region: Clp_N; pfam02861
568206000689	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206000690	Walker A motif; other site
568206000691	ATP binding site [chemical binding]; other site
568206000692	Walker B motif; other site
568206000693	arginine finger; other site
568206000694	UvrB/uvrC motif; Region: UVR; pfam02151
568206000695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206000696	Walker A motif; other site
568206000697	ATP binding site [chemical binding]; other site
568206000698	Walker B motif; other site
568206000699	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
568206000700	DNA repair protein RadA; Provisional; Region: PRK11823
568206000701	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
568206000702	Walker A motif/ATP binding site; other site
568206000703	ATP binding site [chemical binding]; other site
568206000704	Walker B motif; other site
568206000705	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
568206000706	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
568206000707	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
568206000708	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
568206000709	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
568206000710	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
568206000711	putative active site [active]
568206000712	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
568206000713	substrate binding site; other site
568206000714	dimer interface; other site
568206000715	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
568206000716	homotrimer interaction site [polypeptide binding]; other site
568206000717	zinc binding site [ion binding]; other site
568206000718	CDP-binding sites; other site
568206000719	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
568206000720	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
568206000721	active site
568206000722	HIGH motif; other site
568206000723	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
568206000724	active site
568206000725	KMSKS motif; other site
568206000726	serine O-acetyltransferase; Region: cysE; TIGR01172
568206000727	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
568206000728	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
568206000729	trimer interface [polypeptide binding]; other site
568206000730	active site
568206000731	substrate binding site [chemical binding]; other site
568206000732	CoA binding site [chemical binding]; other site
568206000733	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
568206000734	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
568206000735	active site
568206000736	HIGH motif; other site
568206000737	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
568206000738	KMSKS motif; other site
568206000739	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
568206000740	tRNA binding surface [nucleotide binding]; other site
568206000741	anticodon binding site; other site
568206000742	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
568206000743	active site
568206000744	metal binding site [ion binding]; metal-binding site
568206000745	dimerization interface [polypeptide binding]; other site
568206000746	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
568206000747	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
568206000748	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
568206000749	YacP-like NYN domain; Region: NYN_YacP; pfam05991
568206000750	RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859
568206000751	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206000752	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
568206000753	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
568206000754	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
568206000755	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
568206000756	putative homodimer interface [polypeptide binding]; other site
568206000757	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
568206000758	heterodimer interface [polypeptide binding]; other site
568206000759	homodimer interface [polypeptide binding]; other site
568206000760	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
568206000761	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
568206000762	23S rRNA interface [nucleotide binding]; other site
568206000763	L7/L12 interface [polypeptide binding]; other site
568206000764	putative thiostrepton binding site; other site
568206000765	L25 interface [polypeptide binding]; other site
568206000766	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
568206000767	mRNA/rRNA interface [nucleotide binding]; other site
568206000768	Ribosomal protein L10 leader
568206000769	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
568206000770	23S rRNA interface [nucleotide binding]; other site
568206000771	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
568206000772	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
568206000773	core dimer interface [polypeptide binding]; other site
568206000774	peripheral dimer interface [polypeptide binding]; other site
568206000775	L10 interface [polypeptide binding]; other site
568206000776	L11 interface [polypeptide binding]; other site
568206000777	putative EF-Tu interaction site [polypeptide binding]; other site
568206000778	putative EF-G interaction site [polypeptide binding]; other site
568206000779	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
568206000780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206000781	S-adenosylmethionine binding site [chemical binding]; other site
568206000782	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
568206000783	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
568206000784	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
568206000785	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
568206000786	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
568206000787	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
568206000788	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
568206000789	RPB10 interaction site [polypeptide binding]; other site
568206000790	RPB1 interaction site [polypeptide binding]; other site
568206000791	RPB11 interaction site [polypeptide binding]; other site
568206000792	RPB3 interaction site [polypeptide binding]; other site
568206000793	RPB12 interaction site [polypeptide binding]; other site
568206000794	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
568206000795	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
568206000796	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
568206000797	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
568206000798	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
568206000799	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
568206000800	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
568206000801	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
568206000802	G-loop; other site
568206000803	DNA binding site [nucleotide binding]
568206000804	hypothetical protein; Provisional; Region: PRK06683
568206000805	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
568206000806	S17 interaction site [polypeptide binding]; other site
568206000807	S8 interaction site; other site
568206000808	16S rRNA interaction site [nucleotide binding]; other site
568206000809	streptomycin interaction site [chemical binding]; other site
568206000810	23S rRNA interaction site [nucleotide binding]; other site
568206000811	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
568206000812	30S ribosomal protein S7; Validated; Region: PRK05302
568206000813	elongation factor G; Reviewed; Region: PRK00007
568206000814	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
568206000815	G1 box; other site
568206000816	putative GEF interaction site [polypeptide binding]; other site
568206000817	GTP/Mg2+ binding site [chemical binding]; other site
568206000818	Switch I region; other site
568206000819	G2 box; other site
568206000820	G3 box; other site
568206000821	Switch II region; other site
568206000822	G4 box; other site
568206000823	G5 box; other site
568206000824	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
568206000825	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
568206000826	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
568206000827	elongation factor Tu; Reviewed; Region: PRK00049
568206000828	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
568206000829	G1 box; other site
568206000830	GEF interaction site [polypeptide binding]; other site
568206000831	GTP/Mg2+ binding site [chemical binding]; other site
568206000832	Switch I region; other site
568206000833	G2 box; other site
568206000834	G3 box; other site
568206000835	Switch II region; other site
568206000836	G4 box; other site
568206000837	G5 box; other site
568206000838	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
568206000839	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
568206000840	Antibiotic Binding Site [chemical binding]; other site
568206000841	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
568206000842	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
568206000843	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
568206000844	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
568206000845	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
568206000846	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
568206000847	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
568206000848	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
568206000849	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
568206000850	putative translocon binding site; other site
568206000851	protein-rRNA interface [nucleotide binding]; other site
568206000852	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
568206000853	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
568206000854	G-X-X-G motif; other site
568206000855	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
568206000856	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
568206000857	23S rRNA interface [nucleotide binding]; other site
568206000858	5S rRNA interface [nucleotide binding]; other site
568206000859	putative antibiotic binding site [chemical binding]; other site
568206000860	L25 interface [polypeptide binding]; other site
568206000861	L27 interface [polypeptide binding]; other site
568206000862	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
568206000863	23S rRNA interface [nucleotide binding]; other site
568206000864	putative translocon interaction site; other site
568206000865	signal recognition particle (SRP54) interaction site; other site
568206000866	L23 interface [polypeptide binding]; other site
568206000867	trigger factor interaction site; other site
568206000868	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
568206000869	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
568206000870	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
568206000871	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
568206000872	RNA binding site [nucleotide binding]; other site
568206000873	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
568206000874	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
568206000875	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
568206000876	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
568206000877	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
568206000878	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
568206000879	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
568206000880	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
568206000881	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
568206000882	5S rRNA interface [nucleotide binding]; other site
568206000883	L27 interface [polypeptide binding]; other site
568206000884	23S rRNA interface [nucleotide binding]; other site
568206000885	L5 interface [polypeptide binding]; other site
568206000886	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
568206000887	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
568206000888	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
568206000889	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
568206000890	23S rRNA binding site [nucleotide binding]; other site
568206000891	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
568206000892	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
568206000893	SecY translocase; Region: SecY; pfam00344
568206000894	adenylate kinase; Reviewed; Region: adk; PRK00279
568206000895	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
568206000896	AMP-binding site [chemical binding]; other site
568206000897	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
568206000898	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
568206000899	active site
568206000900	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
568206000901	rRNA binding site [nucleotide binding]; other site
568206000902	predicted 30S ribosome binding site; other site
568206000903	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
568206000904	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
568206000905	30S ribosomal protein S13; Region: bact_S13; TIGR03631
568206000906	30S ribosomal protein S11; Validated; Region: PRK05309
568206000907	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
568206000908	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
568206000909	alphaNTD - beta interaction site [polypeptide binding]; other site
568206000910	alphaNTD homodimer interface [polypeptide binding]; other site
568206000911	alphaNTD - beta' interaction site [polypeptide binding]; other site
568206000912	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
568206000913	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
568206000914	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
568206000915	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568206000916	Walker A/P-loop; other site
568206000917	ATP binding site [chemical binding]; other site
568206000918	Q-loop/lid; other site
568206000919	ABC transporter signature motif; other site
568206000920	Walker B; other site
568206000921	D-loop; other site
568206000922	H-loop/switch region; other site
568206000923	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
568206000924	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568206000925	Walker A/P-loop; other site
568206000926	ATP binding site [chemical binding]; other site
568206000927	Q-loop/lid; other site
568206000928	ABC transporter signature motif; other site
568206000929	Walker B; other site
568206000930	D-loop; other site
568206000931	H-loop/switch region; other site
568206000932	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
568206000933	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
568206000934	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
568206000935	dimerization interface 3.5A [polypeptide binding]; other site
568206000936	active site
568206000937	Ribosomal protein L13 leader
568206000938	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
568206000939	23S rRNA interface [nucleotide binding]; other site
568206000940	L3 interface [polypeptide binding]; other site
568206000941	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
568206000942	Protein of unknown function (DUF2521); Region: DUF2521; pfam10730
568206000943	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
568206000944	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568206000945	active site
568206000946	metal binding site [ion binding]; metal-binding site
568206000947	Domain of unknown function DUF59; Region: DUF59; pfam01883
568206000948	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
568206000949	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
568206000950	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
568206000951	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568206000952	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
568206000953	NodB motif; other site
568206000954	putative active site [active]
568206000955	putative catalytic site [active]
568206000956	Glycerate kinase family; Region: Gly_kinase; cl00841
568206000957	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
568206000958	Arginase family; Region: Arginase; cd09989
568206000959	agmatinase; Region: agmatinase; TIGR01230
568206000960	active site
568206000961	Mn binding site [ion binding]; other site
568206000962	oligomer interface [polypeptide binding]; other site
568206000963	Uncharacterized conserved protein [Function unknown]; Region: COG1624
568206000964	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
568206000965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
568206000966	YbbR-like protein; Region: YbbR; pfam07949
568206000967	YbbR-like protein; Region: YbbR; pfam07949
568206000968	YbbR-like protein; Region: YbbR; pfam07949
568206000969	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
568206000970	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
568206000971	active site
568206000972	substrate binding site [chemical binding]; other site
568206000973	metal binding site [ion binding]; metal-binding site
568206000974	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
568206000975	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
568206000976	glutaminase active site [active]
568206000977	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
568206000978	dimer interface [polypeptide binding]; other site
568206000979	active site
568206000980	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
568206000981	dimer interface [polypeptide binding]; other site
568206000982	active site
568206000983	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206000984	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568206000985	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206000986	DNA-binding site [nucleotide binding]; DNA binding site
568206000987	FCD domain; Region: FCD; pfam07729
568206000988	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568206000989	nucleotide binding site [chemical binding]; other site
568206000990	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
568206000991	N- and C-terminal domain interface [polypeptide binding]; other site
568206000992	active site
568206000993	carbohydrate binding site [chemical binding]; other site
568206000994	ATP binding site [chemical binding]; other site
568206000995	fructuronate transporter; Provisional; Region: PRK10034; cl15264
568206000996	gluconate transporter; Region: gntP; TIGR00791
568206000997	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
568206000998	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
568206000999	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
568206001000	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
568206001001	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
568206001002	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
568206001003	DoxX; Region: DoxX; cl17842
568206001004	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
568206001005	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
568206001006	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
568206001007	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206001008	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206001009	DNA binding residues [nucleotide binding]
568206001010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206001011	classical (c) SDRs; Region: SDR_c; cd05233
568206001012	NAD(P) binding site [chemical binding]; other site
568206001013	active site
568206001014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001015	ABC-ATPase subunit interface; other site
568206001016	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
568206001017	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
568206001018	Walker A/P-loop; other site
568206001019	ATP binding site [chemical binding]; other site
568206001020	Q-loop/lid; other site
568206001021	ABC transporter signature motif; other site
568206001022	Walker B; other site
568206001023	D-loop; other site
568206001024	H-loop/switch region; other site
568206001025	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568206001026	NIL domain; Region: NIL; pfam09383
568206001027	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
568206001028	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
568206001029	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568206001030	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
568206001031	putative NAD(P) binding site [chemical binding]; other site
568206001032	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
568206001033	FAD binding domain; Region: FAD_binding_4; pfam01565
568206001034	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206001035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206001036	putative substrate translocation pore; other site
568206001037	Domain of unknown function (DUF3981); Region: DUF3981; pfam13139
568206001038	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
568206001039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206001040	putative substrate translocation pore; other site
568206001041	Protein of unknown function (DUF3887); Region: DUF3887; pfam13026
568206001042	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
568206001043	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206001044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001045	dimer interface [polypeptide binding]; other site
568206001046	conserved gate region; other site
568206001047	putative PBP binding loops; other site
568206001048	ABC-ATPase subunit interface; other site
568206001049	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568206001050	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
568206001051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001052	dimer interface [polypeptide binding]; other site
568206001053	conserved gate region; other site
568206001054	putative PBP binding loops; other site
568206001055	ABC-ATPase subunit interface; other site
568206001056	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568206001057	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206001058	Walker A/P-loop; other site
568206001059	ATP binding site [chemical binding]; other site
568206001060	Q-loop/lid; other site
568206001061	ABC transporter signature motif; other site
568206001062	Walker B; other site
568206001063	D-loop; other site
568206001064	H-loop/switch region; other site
568206001065	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568206001066	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
568206001067	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206001068	Walker A/P-loop; other site
568206001069	ATP binding site [chemical binding]; other site
568206001070	Q-loop/lid; other site
568206001071	ABC transporter signature motif; other site
568206001072	Walker B; other site
568206001073	D-loop; other site
568206001074	H-loop/switch region; other site
568206001075	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
568206001076	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206001077	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206001078	peptide binding site [polypeptide binding]; other site
568206001079	YusW-like protein; Region: YusW; pfam14039
568206001080	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206001081	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568206001082	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206001083	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
568206001084	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206001085	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206001086	peptide binding site [polypeptide binding]; other site
568206001087	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206001088	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206001089	peptide binding site [polypeptide binding]; other site
568206001090	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206001091	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206001092	active site
568206001093	catalytic tetrad [active]
568206001094	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634
568206001095	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
568206001096	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
568206001097	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
568206001098	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
568206001099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001100	dimer interface [polypeptide binding]; other site
568206001101	conserved gate region; other site
568206001102	putative PBP binding loops; other site
568206001103	ABC-ATPase subunit interface; other site
568206001104	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
568206001105	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
568206001106	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
568206001107	DNA binding domain, excisionase family; Region: excise; TIGR01764
568206001108	PBP superfamily domain; Region: PBP_like; pfam12727
568206001109	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206001110	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206001111	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
568206001112	putative dimerization interface [polypeptide binding]; other site
568206001113	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206001114	EamA-like transporter family; Region: EamA; pfam00892
568206001115	YrzO-like protein; Region: YrzO; pfam14142
568206001116	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
568206001117	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
568206001118	putative acyl-acceptor binding pocket; other site
568206001119	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206001120	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206001121	DNA binding site [nucleotide binding]
568206001122	domain linker motif; other site
568206001123	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568206001124	putative ligand binding site [chemical binding]; other site
568206001125	putative dimerization interface [polypeptide binding]; other site
568206001126	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206001127	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206001128	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206001129	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206001130	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
568206001131	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
568206001132	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
568206001133	active site
568206001134	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
568206001135	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
568206001136	C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441
568206001137	lysozyme catalytic site [active]
568206001138	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
568206001139	nucleotide binding site/active site [active]
568206001140	HIT family signature motif; other site
568206001141	catalytic residue [active]
568206001142	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568206001143	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206001144	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206001145	ABC transporter; Region: ABC_tran_2; pfam12848
568206001146	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206001147	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
568206001148	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
568206001149	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206001150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001151	dimer interface [polypeptide binding]; other site
568206001152	conserved gate region; other site
568206001153	putative PBP binding loops; other site
568206001154	ABC-ATPase subunit interface; other site
568206001155	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568206001156	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
568206001157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001158	dimer interface [polypeptide binding]; other site
568206001159	conserved gate region; other site
568206001160	putative PBP binding loops; other site
568206001161	ABC-ATPase subunit interface; other site
568206001162	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568206001163	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206001164	Walker A/P-loop; other site
568206001165	ATP binding site [chemical binding]; other site
568206001166	Q-loop/lid; other site
568206001167	ABC transporter signature motif; other site
568206001168	Walker B; other site
568206001169	D-loop; other site
568206001170	H-loop/switch region; other site
568206001171	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
568206001172	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
568206001173	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206001174	Walker A/P-loop; other site
568206001175	ATP binding site [chemical binding]; other site
568206001176	Q-loop/lid; other site
568206001177	ABC transporter signature motif; other site
568206001178	Walker B; other site
568206001179	D-loop; other site
568206001180	H-loop/switch region; other site
568206001181	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
568206001182	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206001183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206001184	motif II; other site
568206001185	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
568206001186	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206001187	active site
568206001188	motif I; other site
568206001189	motif II; other site
568206001190	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
568206001191	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
568206001192	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
568206001193	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
568206001194	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
568206001195	dimer interface [polypeptide binding]; other site
568206001196	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
568206001197	active site
568206001198	Fe binding site [ion binding]; other site
568206001199	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
568206001200	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
568206001201	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
568206001202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206001203	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206001204	putative substrate translocation pore; other site
568206001205	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
568206001206	ATP-grasp domain; Region: ATP-grasp_4; cl17255
568206001207	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
568206001208	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568206001209	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568206001210	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568206001211	helicase 45; Provisional; Region: PTZ00424
568206001212	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
568206001213	ATP binding site [chemical binding]; other site
568206001214	Mg++ binding site [ion binding]; other site
568206001215	motif III; other site
568206001216	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206001217	nucleotide binding region [chemical binding]; other site
568206001218	ATP-binding site [chemical binding]; other site
568206001219	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
568206001220	Rhomboid family; Region: Rhomboid; pfam01694
568206001221	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
568206001222	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
568206001223	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
568206001224	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
568206001225	alanine racemase; Reviewed; Region: alr; PRK00053
568206001226	active site
568206001227	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568206001228	dimer interface [polypeptide binding]; other site
568206001229	substrate binding site [chemical binding]; other site
568206001230	catalytic residues [active]
568206001231	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
568206001232	PemK-like protein; Region: PemK; pfam02452
568206001233	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
568206001234	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
568206001235	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
568206001236	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
568206001237	RNA binding site [nucleotide binding]; other site
568206001238	hypothetical protein; Provisional; Region: PRK04351
568206001239	SprT homologues; Region: SprT; cl01182
568206001240	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
568206001241	Glycoprotease family; Region: Peptidase_M22; pfam00814
568206001242	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
568206001243	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
568206001244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206001245	Coenzyme A binding pocket [chemical binding]; other site
568206001246	UGMP family protein; Validated; Region: PRK09604
568206001247	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
568206001248	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568206001249	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568206001250	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206001251	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206001252	ABC transporter; Region: ABC_tran_2; pfam12848
568206001253	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206001254	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
568206001255	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
568206001256	CoA binding domain; Region: CoA_binding; pfam02629
568206001257	Domain of unknown function (DUF4305); Region: DUF4305; pfam14146
568206001258	CAAX protease self-immunity; Region: Abi; pfam02517
568206001259	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
568206001260	oligomerisation interface [polypeptide binding]; other site
568206001261	mobile loop; other site
568206001262	roof hairpin; other site
568206001263	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
568206001264	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
568206001265	ring oligomerisation interface [polypeptide binding]; other site
568206001266	ATP/Mg binding site [chemical binding]; other site
568206001267	stacking interactions; other site
568206001268	hinge regions; other site
568206001269	GMP synthase; Reviewed; Region: guaA; PRK00074
568206001270	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
568206001271	AMP/PPi binding site [chemical binding]; other site
568206001272	candidate oxyanion hole; other site
568206001273	catalytic triad [active]
568206001274	potential glutamine specificity residues [chemical binding]; other site
568206001275	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
568206001276	ATP Binding subdomain [chemical binding]; other site
568206001277	Ligand Binding sites [chemical binding]; other site
568206001278	Dimerization subdomain; other site
568206001279	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
568206001280	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206001281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206001282	active site
568206001283	phosphorylation site [posttranslational modification]
568206001284	intermolecular recognition site; other site
568206001285	dimerization interface [polypeptide binding]; other site
568206001286	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206001287	DNA binding site [nucleotide binding]
568206001288	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206001289	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206001290	dimerization interface [polypeptide binding]; other site
568206001291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206001292	dimer interface [polypeptide binding]; other site
568206001293	phosphorylation site [posttranslational modification]
568206001294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206001295	ATP binding site [chemical binding]; other site
568206001296	Mg2+ binding site [ion binding]; other site
568206001297	G-X-G motif; other site
568206001298	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
568206001299	putative ligand binding site [chemical binding]; other site
568206001300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206001301	S-adenosylmethionine binding site [chemical binding]; other site
568206001302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206001303	S-adenosylmethionine binding site [chemical binding]; other site
568206001304	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
568206001305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206001306	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568206001307	NAD(P) binding site [chemical binding]; other site
568206001308	active site
568206001309	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206001310	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206001311	S-adenosylmethionine binding site [chemical binding]; other site
568206001312	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206001313	potential frameshift: common BLAST hit: gi|49183297|ref|YP_026549.1| glycosyl transferase, group 1 family protein
568206001314	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568206001315	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206001316	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568206001317	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568206001318	active site
568206001319	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568206001320	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
568206001321	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568206001322	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206001323	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
568206001324	Walker A/P-loop; other site
568206001325	ATP binding site [chemical binding]; other site
568206001326	Q-loop/lid; other site
568206001327	ABC transporter signature motif; other site
568206001328	Walker B; other site
568206001329	D-loop; other site
568206001330	H-loop/switch region; other site
568206001331	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206001332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206001333	dimer interface [polypeptide binding]; other site
568206001334	phosphorylation site [posttranslational modification]
568206001335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206001336	ATP binding site [chemical binding]; other site
568206001337	Mg2+ binding site [ion binding]; other site
568206001338	G-X-G motif; other site
568206001339	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206001340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206001341	active site
568206001342	phosphorylation site [posttranslational modification]
568206001343	intermolecular recognition site; other site
568206001344	dimerization interface [polypeptide binding]; other site
568206001345	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206001346	DNA binding site [nucleotide binding]
568206001347	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
568206001348	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
568206001349	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
568206001350	NAD binding site [chemical binding]; other site
568206001351	ATP-grasp domain; Region: ATP-grasp; pfam02222
568206001352	adenylosuccinate lyase; Provisional; Region: PRK07492
568206001353	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
568206001354	tetramer interface [polypeptide binding]; other site
568206001355	active site
568206001356	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
568206001357	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
568206001358	ATP binding site [chemical binding]; other site
568206001359	active site
568206001360	substrate binding site [chemical binding]; other site
568206001361	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
568206001362	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
568206001363	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
568206001364	putative active site [active]
568206001365	catalytic triad [active]
568206001366	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
568206001367	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
568206001368	dimerization interface [polypeptide binding]; other site
568206001369	ATP binding site [chemical binding]; other site
568206001370	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
568206001371	dimerization interface [polypeptide binding]; other site
568206001372	ATP binding site [chemical binding]; other site
568206001373	amidophosphoribosyltransferase; Provisional; Region: PRK06781
568206001374	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
568206001375	active site
568206001376	tetramer interface [polypeptide binding]; other site
568206001377	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206001378	active site
568206001379	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
568206001380	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
568206001381	dimerization interface [polypeptide binding]; other site
568206001382	putative ATP binding site [chemical binding]; other site
568206001383	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
568206001384	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
568206001385	active site
568206001386	substrate binding site [chemical binding]; other site
568206001387	cosubstrate binding site; other site
568206001388	catalytic site [active]
568206001389	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
568206001390	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
568206001391	purine monophosphate binding site [chemical binding]; other site
568206001392	dimer interface [polypeptide binding]; other site
568206001393	putative catalytic residues [active]
568206001394	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
568206001395	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
568206001396	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
568206001397	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
568206001398	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
568206001399	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
568206001400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
568206001401	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
568206001402	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
568206001403	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
568206001404	PcrB family; Region: PcrB; pfam01884
568206001405	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
568206001406	substrate binding site [chemical binding]; other site
568206001407	putative active site [active]
568206001408	dimer interface [polypeptide binding]; other site
568206001409	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
568206001410	Part of AAA domain; Region: AAA_19; pfam13245
568206001411	Family description; Region: UvrD_C_2; pfam13538
568206001412	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
568206001413	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
568206001414	nucleotide binding pocket [chemical binding]; other site
568206001415	K-X-D-G motif; other site
568206001416	catalytic site [active]
568206001417	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
568206001418	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
568206001419	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
568206001420	Dimer interface [polypeptide binding]; other site
568206001421	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
568206001422	putative dimer interface [polypeptide binding]; other site
568206001423	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
568206001424	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
568206001425	putative dimer interface [polypeptide binding]; other site
568206001426	hypothetical protein; Provisional; Region: PRK10621
568206001427	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
568206001428	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
568206001429	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
568206001430	Glutamate binding site [chemical binding]; other site
568206001431	homodimer interface [polypeptide binding]; other site
568206001432	NAD binding site [chemical binding]; other site
568206001433	catalytic residues [active]
568206001434	Isochorismatase family; Region: Isochorismatase; pfam00857
568206001435	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
568206001436	catalytic triad [active]
568206001437	conserved cis-peptide bond; other site
568206001438	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
568206001439	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
568206001440	Walker A/P-loop; other site
568206001441	ATP binding site [chemical binding]; other site
568206001442	Q-loop/lid; other site
568206001443	ABC transporter signature motif; other site
568206001444	Walker B; other site
568206001445	D-loop; other site
568206001446	H-loop/switch region; other site
568206001447	NIL domain; Region: NIL; pfam09383
568206001448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001449	dimer interface [polypeptide binding]; other site
568206001450	conserved gate region; other site
568206001451	ABC-ATPase subunit interface; other site
568206001452	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
568206001453	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
568206001454	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
568206001455	Protein of unknown function (DUF3926); Region: DUF3926; pfam13080
568206001456	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
568206001457	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
568206001458	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
568206001459	P loop; other site
568206001460	Nucleotide binding site [chemical binding]; other site
568206001461	DTAP/Switch II; other site
568206001462	Switch I; other site
568206001463	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206001464	MarR family; Region: MarR; pfam01047
568206001465	MarR family; Region: MarR_2; cl17246
568206001466	yiaA/B two helix domain; Region: YiaAB; pfam05360
568206001467	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
568206001468	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
568206001469	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
568206001470	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
568206001471	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
568206001472	GatB domain; Region: GatB_Yqey; pfam02637
568206001473	putative lipid kinase; Reviewed; Region: PRK13337
568206001474	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
568206001475	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
568206001476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206001477	motif II; other site
568206001478	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
568206001479	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206001480	inhibitor-cofactor binding pocket; inhibition site
568206001481	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206001482	catalytic residue [active]
568206001483	PAS domain; Region: PAS_9; pfam13426
568206001484	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206001485	putative active site [active]
568206001486	heme pocket [chemical binding]; other site
568206001487	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
568206001488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206001489	Walker A motif; other site
568206001490	ATP binding site [chemical binding]; other site
568206001491	Walker B motif; other site
568206001492	arginine finger; other site
568206001493	succinic semialdehyde dehydrogenase; Region: PLN02278
568206001494	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
568206001495	tetramerization interface [polypeptide binding]; other site
568206001496	NAD(P) binding site [chemical binding]; other site
568206001497	catalytic residues [active]
568206001498	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
568206001499	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
568206001500	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
568206001501	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568206001502	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
568206001503	putative active site [active]
568206001504	putative metal binding site [ion binding]; other site
568206001505	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568206001506	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
568206001507	putative active site [active]
568206001508	putative metal binding site [ion binding]; other site
568206001509	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
568206001510	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
568206001511	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
568206001512	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
568206001513	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
568206001514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206001515	S-adenosylmethionine binding site [chemical binding]; other site
568206001516	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
568206001517	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
568206001518	FMN binding site [chemical binding]; other site
568206001519	active site
568206001520	catalytic residues [active]
568206001521	substrate binding site [chemical binding]; other site
568206001522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
568206001523	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
568206001524	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
568206001525	Protein of unknown function DUF45; Region: DUF45; pfam01863
568206001526	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
568206001527	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
568206001528	active site
568206001529	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
568206001530	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568206001531	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
568206001532	metal binding site [ion binding]; metal-binding site
568206001533	putative dimer interface [polypeptide binding]; other site
568206001534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206001535	S-adenosylmethionine binding site [chemical binding]; other site
568206001536	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
568206001537	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
568206001538	catalytic residue [active]
568206001539	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
568206001540	catalytic residues [active]
568206001541	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206001542	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206001543	peroxiredoxin; Region: AhpC; TIGR03137
568206001544	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
568206001545	dimer interface [polypeptide binding]; other site
568206001546	decamer (pentamer of dimers) interface [polypeptide binding]; other site
568206001547	catalytic triad [active]
568206001548	peroxidatic and resolving cysteines [active]
568206001549	5-methylribose kinase; Reviewed; Region: PRK12396
568206001550	Phosphotransferase enzyme family; Region: APH; pfam01636
568206001551	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
568206001552	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
568206001553	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
568206001554	intersubunit interface [polypeptide binding]; other site
568206001555	active site
568206001556	Zn2+ binding site [ion binding]; other site
568206001557	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206001558	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206001559	ABC-ATPase subunit  interface; other site
568206001560	dimer interface [polypeptide binding]; other site
568206001561	putative PBP binding regions; other site
568206001562	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206001563	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206001564	ABC-ATPase subunit  interface; other site
568206001565	dimer interface [polypeptide binding]; other site
568206001566	putative PBP binding regions; other site
568206001567	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
568206001568	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
568206001569	putative ligand binding residues [chemical binding]; other site
568206001570	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
568206001571	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206001572	DNA binding domain, excisionase family; Region: excise; TIGR01764
568206001573	Sm and related proteins; Region: Sm_like; cl00259
568206001574	Sm1 motif; other site
568206001575	RNA binding site [nucleotide binding]; other site
568206001576	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
568206001577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206001578	ATP binding site [chemical binding]; other site
568206001579	G-X-G motif; other site
568206001580	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
568206001581	hypothetical protein; Provisional; Region: PRK06851
568206001582	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
568206001583	Walker A motif; other site
568206001584	ATP binding site [chemical binding]; other site
568206001585	NTPase; Region: NTPase_1; cl17478
568206001586	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
568206001587	benzoate transport; Region: 2A0115; TIGR00895
568206001588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206001589	putative substrate translocation pore; other site
568206001590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206001591	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
568206001592	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
568206001593	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
568206001594	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
568206001595	[2Fe-2S] cluster binding site [ion binding]; other site
568206001596	Fatty acid desaturase; Region: FA_desaturase; pfam00487
568206001597	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
568206001598	putative di-iron ligands [ion binding]; other site
568206001599	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001600	dimer interface [polypeptide binding]; other site
568206001601	conserved gate region; other site
568206001602	putative PBP binding loops; other site
568206001603	ABC-ATPase subunit interface; other site
568206001604	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568206001605	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568206001606	substrate binding pocket [chemical binding]; other site
568206001607	membrane-bound complex binding site; other site
568206001608	hinge residues; other site
568206001609	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568206001610	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
568206001611	Walker A/P-loop; other site
568206001612	ATP binding site [chemical binding]; other site
568206001613	Q-loop/lid; other site
568206001614	ABC transporter signature motif; other site
568206001615	Walker B; other site
568206001616	D-loop; other site
568206001617	H-loop/switch region; other site
568206001618	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
568206001619	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
568206001620	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206001621	dimerization interface [polypeptide binding]; other site
568206001622	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206001623	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206001624	dimer interface [polypeptide binding]; other site
568206001625	putative CheW interface [polypeptide binding]; other site
568206001626	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
568206001627	HAMP domain; Region: HAMP; pfam00672
568206001628	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206001629	dimer interface [polypeptide binding]; other site
568206001630	putative CheW interface [polypeptide binding]; other site
568206001631	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568206001632	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
568206001633	Ca binding site [ion binding]; other site
568206001634	active site
568206001635	catalytic site [active]
568206001636	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568206001637	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
568206001638	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568206001639	active site turn [active]
568206001640	phosphorylation site [posttranslational modification]
568206001641	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
568206001642	putative catalytic site [active]
568206001643	putative metal binding site [ion binding]; other site
568206001644	putative phosphate binding site [ion binding]; other site
568206001645	Predicted membrane protein [Function unknown]; Region: COG1511
568206001646	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568206001647	Predicted membrane protein [Function unknown]; Region: COG1511
568206001648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206001649	DNA topoisomerase III; Provisional; Region: PRK07726
568206001650	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
568206001651	active site
568206001652	putative interdomain interaction site [polypeptide binding]; other site
568206001653	putative metal-binding site [ion binding]; other site
568206001654	putative nucleotide binding site [chemical binding]; other site
568206001655	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
568206001656	domain I; other site
568206001657	DNA binding groove [nucleotide binding]
568206001658	phosphate binding site [ion binding]; other site
568206001659	domain II; other site
568206001660	domain III; other site
568206001661	nucleotide binding site [chemical binding]; other site
568206001662	catalytic site [active]
568206001663	domain IV; other site
568206001664	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
568206001665	substrate binding site [chemical binding]; other site
568206001666	multimerization interface [polypeptide binding]; other site
568206001667	ATP binding site [chemical binding]; other site
568206001668	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
568206001669	thiamine phosphate binding site [chemical binding]; other site
568206001670	active site
568206001671	pyrophosphate binding site [ion binding]; other site
568206001672	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
568206001673	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
568206001674	HAMP domain; Region: HAMP; pfam00672
568206001675	dimerization interface [polypeptide binding]; other site
568206001676	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206001677	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206001678	dimer interface [polypeptide binding]; other site
568206001679	putative CheW interface [polypeptide binding]; other site
568206001680	Domain of unknown function DUF77; Region: DUF77; pfam01910
568206001681	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
568206001682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206001683	dimer interface [polypeptide binding]; other site
568206001684	conserved gate region; other site
568206001685	putative PBP binding loops; other site
568206001686	ABC-ATPase subunit interface; other site
568206001687	NMT1/THI5 like; Region: NMT1; pfam09084
568206001688	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
568206001689	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
568206001690	Walker A/P-loop; other site
568206001691	ATP binding site [chemical binding]; other site
568206001692	Q-loop/lid; other site
568206001693	ABC transporter signature motif; other site
568206001694	Walker B; other site
568206001695	D-loop; other site
568206001696	H-loop/switch region; other site
568206001697	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568206001698	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206001699	Walker A/P-loop; other site
568206001700	ATP binding site [chemical binding]; other site
568206001701	Q-loop/lid; other site
568206001702	ABC transporter signature motif; other site
568206001703	Walker B; other site
568206001704	D-loop; other site
568206001705	H-loop/switch region; other site
568206001706	ABC transporter; Region: ABC_tran_2; pfam12848
568206001707	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206001708	Glyco_18 domain; Region: Glyco_18; smart00636
568206001709	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
568206001710	active site
568206001711	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
568206001712	Interdomain contacts; other site
568206001713	Cytokine receptor motif; other site
568206001714	CBD_II domain; Region: CBD_II; smart00637
568206001715	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
568206001716	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568206001717	catalytic residues [active]
568206001718	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206001719	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206001720	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
568206001721	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206001722	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206001723	putative substrate translocation pore; other site
568206001724	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206001725	non-specific DNA binding site [nucleotide binding]; other site
568206001726	salt bridge; other site
568206001727	sequence-specific DNA binding site [nucleotide binding]; other site
568206001728	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
568206001729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206001730	putative substrate translocation pore; other site
568206001731	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
568206001732	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
568206001733	YesK-like protein; Region: YesK; pfam14150
568206001734	prolyl-tRNA synthetase; Provisional; Region: PRK08661
568206001735	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
568206001736	dimer interface [polypeptide binding]; other site
568206001737	motif 1; other site
568206001738	active site
568206001739	motif 2; other site
568206001740	motif 3; other site
568206001741	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
568206001742	anticodon binding site; other site
568206001743	zinc-binding site [ion binding]; other site
568206001744	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568206001745	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568206001746	nucleotide binding site [chemical binding]; other site
568206001747	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
568206001748	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
568206001749	putative metal binding site [ion binding]; other site
568206001750	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
568206001751	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
568206001752	putative metal binding site [ion binding]; other site
568206001753	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
568206001754	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
568206001755	putative metal binding site [ion binding]; other site
568206001756	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
568206001757	potential frameshift: common BLAST hit: gi|49480821|ref|YP_034730.1| tellurium resistance protein
568206001758	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
568206001759	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
568206001760	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
568206001761	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
568206001762	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
568206001763	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568206001764	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
568206001765	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
568206001766	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
568206001767	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
568206001768	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
568206001769	Low molecular weight phosphatase family; Region: LMWPc; cd00115
568206001770	active site
568206001771	Domain of unknown function (DUF4075); Region: DUF4075; pfam13294
568206001772	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
568206001773	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
568206001774	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568206001775	Soluble P-type ATPase [General function prediction only]; Region: COG4087
568206001776	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206001777	EamA-like transporter family; Region: EamA; pfam00892
568206001778	EamA-like transporter family; Region: EamA; pfam00892
568206001779	YhhN-like protein; Region: YhhN; pfam07947
568206001780	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568206001781	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206001782	Catalytic site [active]
568206001783	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206001784	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206001785	binding surface
568206001786	Tetratricopeptide repeat; Region: TPR_16; pfam13432
568206001787	TPR motif; other site
568206001788	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568206001789	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568206001790	potential frameshift: common BLAST hit: gi|225862457|ref|YP_002747835.1| transporter, EamA family
568206001791	EamA-like transporter family; Region: EamA; cl17759
568206001792	EamA-like transporter family; Region: EamA; cl17759
568206001793	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
568206001794	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
568206001795	calcium/proton exchanger (cax); Region: cax; TIGR00378
568206001796	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
568206001797	YfkD-like protein; Region: YfkD; pfam14167
568206001798	Radical SAM superfamily; Region: Radical_SAM; pfam04055
568206001799	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206001800	FeS/SAM binding site; other site
568206001801	YfkB-like domain; Region: YfkB; pfam08756
568206001802	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
568206001803	Fumarase C-terminus; Region: Fumerase_C; pfam05683
568206001804	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
568206001805	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
568206001806	NodB motif; other site
568206001807	active site
568206001808	catalytic site [active]
568206001809	Cd binding site [ion binding]; other site
568206001810	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568206001811	endonuclease III; Region: ENDO3c; smart00478
568206001812	minor groove reading motif; other site
568206001813	helix-hairpin-helix signature motif; other site
568206001814	substrate binding pocket [chemical binding]; other site
568206001815	active site
568206001816	TRAM domain; Region: TRAM; pfam01938
568206001817	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
568206001818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206001819	S-adenosylmethionine binding site [chemical binding]; other site
568206001820	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
568206001821	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
568206001822	Int/Topo IB signature motif; other site
568206001823	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206001824	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206001825	non-specific DNA binding site [nucleotide binding]; other site
568206001826	salt bridge; other site
568206001827	sequence-specific DNA binding site [nucleotide binding]; other site
568206001828	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206001829	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206001830	non-specific DNA binding site [nucleotide binding]; other site
568206001831	salt bridge; other site
568206001832	sequence-specific DNA binding site [nucleotide binding]; other site
568206001833	phage regulatory protein, rha family; Region: phage_pRha; TIGR02681
568206001834	ORF6C domain; Region: ORF6C; pfam10552
568206001835	Helix-turn-helix domain; Region: HTH_17; pfam12728
568206001836	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
568206001837	hypothetical protein; Validated; Region: PRK08116
568206001838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206001839	Walker A motif; other site
568206001840	ATP binding site [chemical binding]; other site
568206001841	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
568206001842	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
568206001843	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
568206001844	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206001845	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206001846	sequence-specific DNA binding site [nucleotide binding]; other site
568206001847	salt bridge; other site
568206001848	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
568206001849	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
568206001850	trimer interface [polypeptide binding]; other site
568206001851	active site
568206001852	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
568206001853	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206001854	active site
568206001855	metal binding site [ion binding]; metal-binding site
568206001856	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869
568206001857	Protein of unknown function (DUF3983); Region: DUF3983; pfam13137
568206001858	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
568206001859	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
568206001860	Int/Topo IB signature motif; other site
568206001861	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
568206001862	HNH endonuclease; Region: HNH; pfam01844
568206001863	active site
568206001864	Phage terminase, small subunit; Region: Terminase_4; pfam05119
568206001865	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
568206001866	Phage-related protein [Function unknown]; Region: COG4695
568206001867	Phage portal protein; Region: Phage_portal; pfam04860
568206001868	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
568206001869	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
568206001870	oligomer interface [polypeptide binding]; other site
568206001871	active site residues [active]
568206001872	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
568206001873	Phage capsid family; Region: Phage_capsid; pfam05065
568206001874	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
568206001875	oligomerization interface [polypeptide binding]; other site
568206001876	phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725
568206001877	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
568206001878	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
568206001879	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
568206001880	putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633
568206001881	Phage tail protein; Region: Sipho_tail; cl17486
568206001882	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
568206001883	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
568206001884	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
568206001885	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
568206001886	active site
568206001887	catalytic residues [active]
568206001888	DNA binding site [nucleotide binding]
568206001889	Int/Topo IB signature motif; other site
568206001890	Holin family; Region: Phage_holin_4; pfam05105
568206001891	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
568206001892	amidase catalytic site [active]
568206001893	Zn binding residues [ion binding]; other site
568206001894	substrate binding site [chemical binding]; other site
568206001895	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
568206001896	hypothetical protein; Region: PHA02436
568206001897	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206001898	non-specific DNA binding site [nucleotide binding]; other site
568206001899	salt bridge; other site
568206001900	sequence-specific DNA binding site [nucleotide binding]; other site
568206001901	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568206001902	Replication-relaxation; Region: Replic_Relax; pfam13814
568206001903	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
568206001904	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
568206001905	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
568206001906	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
568206001907	hypothetical protein; Provisional; Region: PRK13688
568206001908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206001909	Coenzyme A binding pocket [chemical binding]; other site
568206001910	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
568206001911	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
568206001912	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
568206001913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
568206001914	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
568206001915	MraW methylase family; Region: Methyltransf_5; pfam01795
568206001916	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
568206001917	Cell division protein FtsL; Region: FtsL; cl11433
568206001918	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568206001919	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206001920	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206001921	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
568206001922	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
568206001923	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
568206001924	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206001925	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206001926	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
568206001927	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
568206001928	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568206001929	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568206001930	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568206001931	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
568206001932	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
568206001933	Mg++ binding site [ion binding]; other site
568206001934	putative catalytic motif [active]
568206001935	putative substrate binding site [chemical binding]; other site
568206001936	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
568206001937	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
568206001938	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568206001939	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568206001940	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
568206001941	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
568206001942	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
568206001943	active site
568206001944	homodimer interface [polypeptide binding]; other site
568206001945	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
568206001946	FAD binding domain; Region: FAD_binding_4; pfam01565
568206001947	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
568206001948	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
568206001949	Cell division protein FtsQ; Region: FtsQ; pfam03799
568206001950	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
568206001951	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568206001952	nucleotide binding site [chemical binding]; other site
568206001953	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
568206001954	Cell division protein FtsA; Region: FtsA; pfam14450
568206001955	cell division protein FtsZ; Validated; Region: PRK09330
568206001956	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
568206001957	nucleotide binding site [chemical binding]; other site
568206001958	SulA interaction site; other site
568206001959	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
568206001960	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
568206001961	sporulation sigma factor SigE; Reviewed; Region: PRK08301
568206001962	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206001963	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206001964	DNA binding residues [nucleotide binding]
568206001965	sporulation sigma factor SigG; Reviewed; Region: PRK08215
568206001966	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206001967	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206001968	DNA binding residues [nucleotide binding]
568206001969	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
568206001970	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
568206001971	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
568206001972	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
568206001973	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568206001974	catalytic residue [active]
568206001975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
568206001976	YGGT family; Region: YGGT; pfam02325
568206001977	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
568206001978	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206001979	RNA binding surface [nucleotide binding]; other site
568206001980	DivIVA protein; Region: DivIVA; pfam05103
568206001981	DivIVA domain; Region: DivI1A_domain; TIGR03544
568206001982	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
568206001983	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
568206001984	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
568206001985	active site
568206001986	HIGH motif; other site
568206001987	nucleotide binding site [chemical binding]; other site
568206001988	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
568206001989	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
568206001990	active site
568206001991	KMSKS motif; other site
568206001992	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
568206001993	tRNA binding surface [nucleotide binding]; other site
568206001994	anticodon binding site; other site
568206001995	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
568206001996	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
568206001997	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
568206001998	lipoprotein signal peptidase; Provisional; Region: PRK14787
568206001999	potential frameshift: common BLAST hit: gi|225865874|ref|YP_002751252.1| ribosomal large subunit pseudouridine synthase, RluA family
568206002000	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206002001	RNA binding surface [nucleotide binding]; other site
568206002002	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
568206002003	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
568206002004	active site
568206002005	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
568206002006	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206002007	active site
568206002008	uracil transporter; Provisional; Region: PRK10720
568206002009	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
568206002010	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
568206002011	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
568206002012	dihydroorotase; Validated; Region: pyrC; PRK09357
568206002013	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
568206002014	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
568206002015	active site
568206002016	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
568206002017	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
568206002018	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
568206002019	catalytic site [active]
568206002020	subunit interface [polypeptide binding]; other site
568206002021	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
568206002022	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568206002023	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
568206002024	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
568206002025	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568206002026	ATP-grasp domain; Region: ATP-grasp_4; cl17255
568206002027	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
568206002028	IMP binding site; other site
568206002029	dimer interface [polypeptide binding]; other site
568206002030	interdomain contacts; other site
568206002031	partial ornithine binding site; other site
568206002032	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
568206002033	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
568206002034	FAD binding pocket [chemical binding]; other site
568206002035	FAD binding motif [chemical binding]; other site
568206002036	phosphate binding motif [ion binding]; other site
568206002037	beta-alpha-beta structure motif; other site
568206002038	NAD binding pocket [chemical binding]; other site
568206002039	Iron coordination center [ion binding]; other site
568206002040	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
568206002041	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
568206002042	heterodimer interface [polypeptide binding]; other site
568206002043	active site
568206002044	FMN binding site [chemical binding]; other site
568206002045	homodimer interface [polypeptide binding]; other site
568206002046	substrate binding site [chemical binding]; other site
568206002047	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
568206002048	active site
568206002049	dimer interface [polypeptide binding]; other site
568206002050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206002051	active site
568206002052	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
568206002053	motif I; other site
568206002054	active site
568206002055	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
568206002056	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
568206002057	YoqO-like protein; Region: YoqO; pfam14037
568206002058	YoqO-like protein; Region: YoqO; pfam14037
568206002059	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
568206002060	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
568206002061	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
568206002062	active site
568206002063	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
568206002064	Domain of unknown function (DUF814); Region: DUF814; pfam05670
568206002065	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
568206002066	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
568206002067	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568206002068	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
568206002069	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206002070	motif II; other site
568206002071	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
568206002072	hypothetical protein; Provisional; Region: PRK11820
568206002073	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
568206002074	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
568206002075	hypothetical protein; Provisional; Region: PRK04323
568206002076	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
568206002077	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
568206002078	catalytic site [active]
568206002079	G-X2-G-X-G-K; other site
568206002080	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
568206002081	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
568206002082	Flavoprotein; Region: Flavoprotein; pfam02441
568206002083	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
568206002084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206002085	primosomal protein N' Region: priA; TIGR00595
568206002086	ATP binding site [chemical binding]; other site
568206002087	putative Mg++ binding site [ion binding]; other site
568206002088	helicase superfamily c-terminal domain; Region: HELICc; smart00490
568206002089	nucleotide binding region [chemical binding]; other site
568206002090	ATP-binding site [chemical binding]; other site
568206002091	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
568206002092	active site
568206002093	catalytic residues [active]
568206002094	metal binding site [ion binding]; metal-binding site
568206002095	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
568206002096	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
568206002097	putative active site [active]
568206002098	substrate binding site [chemical binding]; other site
568206002099	putative cosubstrate binding site; other site
568206002100	catalytic site [active]
568206002101	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
568206002102	substrate binding site [chemical binding]; other site
568206002103	16S rRNA methyltransferase B; Provisional; Region: PRK14902
568206002104	NusB family; Region: NusB; pfam01029
568206002105	putative RNA binding site [nucleotide binding]; other site
568206002106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206002107	S-adenosylmethionine binding site [chemical binding]; other site
568206002108	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
568206002109	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206002110	FeS/SAM binding site; other site
568206002111	Protein phosphatase 2C; Region: PP2C; pfam00481
568206002112	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
568206002113	active site
568206002114	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
568206002115	Catalytic domain of Protein Kinases; Region: PKc; cd00180
568206002116	active site
568206002117	ATP binding site [chemical binding]; other site
568206002118	substrate binding site [chemical binding]; other site
568206002119	activation loop (A-loop); other site
568206002120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
568206002121	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
568206002122	PASTA domain; Region: PASTA; pfam03793
568206002123	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
568206002124	GTPase RsgA; Reviewed; Region: PRK00098
568206002125	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
568206002126	RNA binding site [nucleotide binding]; other site
568206002127	homodimer interface [polypeptide binding]; other site
568206002128	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
568206002129	GTPase/Zn-binding domain interface [polypeptide binding]; other site
568206002130	GTP/Mg2+ binding site [chemical binding]; other site
568206002131	G4 box; other site
568206002132	G5 box; other site
568206002133	G1 box; other site
568206002134	Switch I region; other site
568206002135	G2 box; other site
568206002136	G3 box; other site
568206002137	Switch II region; other site
568206002138	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568206002139	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
568206002140	substrate binding site [chemical binding]; other site
568206002141	hexamer interface [polypeptide binding]; other site
568206002142	metal binding site [ion binding]; metal-binding site
568206002143	Thiamine pyrophosphokinase; Region: TPK; cd07995
568206002144	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
568206002145	active site
568206002146	dimerization interface [polypeptide binding]; other site
568206002147	thiamine binding site [chemical binding]; other site
568206002148	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
568206002149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
568206002150	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
568206002151	DAK2 domain; Region: Dak2; pfam02734
568206002152	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
568206002153	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
568206002154	generic binding surface II; other site
568206002155	ssDNA binding site; other site
568206002156	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206002157	ATP binding site [chemical binding]; other site
568206002158	putative Mg++ binding site [ion binding]; other site
568206002159	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206002160	nucleotide binding region [chemical binding]; other site
568206002161	ATP-binding site [chemical binding]; other site
568206002162	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
568206002163	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
568206002164	active site 2 [active]
568206002165	active site 1 [active]
568206002166	putative phosphate acyltransferase; Provisional; Region: PRK05331
568206002167	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
568206002168	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
568206002169	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
568206002170	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
568206002171	NAD(P) binding site [chemical binding]; other site
568206002172	homotetramer interface [polypeptide binding]; other site
568206002173	homodimer interface [polypeptide binding]; other site
568206002174	active site
568206002175	acyl carrier protein; Provisional; Region: acpP; PRK00982
568206002176	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
568206002177	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
568206002178	dimerization interface [polypeptide binding]; other site
568206002179	active site
568206002180	metal binding site [ion binding]; metal-binding site
568206002181	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
568206002182	dsRNA binding site [nucleotide binding]; other site
568206002183	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
568206002184	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
568206002185	Walker A/P-loop; other site
568206002186	ATP binding site [chemical binding]; other site
568206002187	Q-loop/lid; other site
568206002188	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
568206002189	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
568206002190	ABC transporter signature motif; other site
568206002191	Walker B; other site
568206002192	D-loop; other site
568206002193	H-loop/switch region; other site
568206002194	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
568206002195	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
568206002196	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
568206002197	P loop; other site
568206002198	GTP binding site [chemical binding]; other site
568206002199	putative DNA-binding protein; Validated; Region: PRK00118
568206002200	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
568206002201	signal recognition particle protein; Provisional; Region: PRK10867
568206002202	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
568206002203	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
568206002204	P loop; other site
568206002205	GTP binding site [chemical binding]; other site
568206002206	Signal peptide binding domain; Region: SRP_SPB; pfam02978
568206002207	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
568206002208	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
568206002209	KH domain; Region: KH_4; pfam13083
568206002210	G-X-X-G motif; other site
568206002211	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
568206002212	RimM N-terminal domain; Region: RimM; pfam01782
568206002213	PRC-barrel domain; Region: PRC; pfam05239
568206002214	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
568206002215	Ribosomal protein L19 leader
568206002216	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
568206002217	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568206002218	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206002219	Catalytic site [active]
568206002220	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206002221	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
568206002222	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
568206002223	GTP/Mg2+ binding site [chemical binding]; other site
568206002224	G4 box; other site
568206002225	G5 box; other site
568206002226	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
568206002227	G1 box; other site
568206002228	G1 box; other site
568206002229	GTP/Mg2+ binding site [chemical binding]; other site
568206002230	Switch I region; other site
568206002231	G2 box; other site
568206002232	G2 box; other site
568206002233	G3 box; other site
568206002234	G3 box; other site
568206002235	Switch II region; other site
568206002236	Switch II region; other site
568206002237	G4 box; other site
568206002238	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
568206002239	RNA/DNA hybrid binding site [nucleotide binding]; other site
568206002240	active site
568206002241	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
568206002242	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
568206002243	CoA-ligase; Region: Ligase_CoA; pfam00549
568206002244	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
568206002245	CoA binding domain; Region: CoA_binding; smart00881
568206002246	CoA-ligase; Region: Ligase_CoA; pfam00549
568206002247	DNA protecting protein DprA; Region: dprA; TIGR00732
568206002248	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
568206002249	DNA topoisomerase I; Validated; Region: PRK05582
568206002250	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
568206002251	active site
568206002252	interdomain interaction site; other site
568206002253	putative metal-binding site [ion binding]; other site
568206002254	nucleotide binding site [chemical binding]; other site
568206002255	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
568206002256	domain I; other site
568206002257	DNA binding groove [nucleotide binding]
568206002258	phosphate binding site [ion binding]; other site
568206002259	domain II; other site
568206002260	domain III; other site
568206002261	nucleotide binding site [chemical binding]; other site
568206002262	catalytic site [active]
568206002263	domain IV; other site
568206002264	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
568206002265	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
568206002266	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
568206002267	Glucose inhibited division protein A; Region: GIDA; pfam01134
568206002268	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
568206002269	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
568206002270	active site
568206002271	Int/Topo IB signature motif; other site
568206002272	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
568206002273	active site
568206002274	HslU subunit interaction site [polypeptide binding]; other site
568206002275	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
568206002276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206002277	Walker A motif; other site
568206002278	ATP binding site [chemical binding]; other site
568206002279	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
568206002280	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
568206002281	transcriptional repressor CodY; Validated; Region: PRK04158
568206002282	CodY GAF-like domain; Region: CodY; pfam06018
568206002283	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
568206002284	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
568206002285	rRNA interaction site [nucleotide binding]; other site
568206002286	S8 interaction site; other site
568206002287	putative laminin-1 binding site; other site
568206002288	elongation factor Ts; Provisional; Region: tsf; PRK09377
568206002289	UBA/TS-N domain; Region: UBA; pfam00627
568206002290	Elongation factor TS; Region: EF_TS; pfam00889
568206002291	Elongation factor TS; Region: EF_TS; pfam00889
568206002292	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
568206002293	putative nucleotide binding site [chemical binding]; other site
568206002294	uridine monophosphate binding site [chemical binding]; other site
568206002295	homohexameric interface [polypeptide binding]; other site
568206002296	ribosome recycling factor; Reviewed; Region: frr; PRK00083
568206002297	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
568206002298	hinge region; other site
568206002299	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
568206002300	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
568206002301	catalytic residue [active]
568206002302	putative FPP diphosphate  binding site; other site
568206002303	putative FPP binding hydrophobic cleft; other site
568206002304	dimer interface [polypeptide binding]; other site
568206002305	putative IPP diphosphate binding site; other site
568206002306	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
568206002307	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
568206002308	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
568206002309	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
568206002310	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
568206002311	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
568206002312	RIP metalloprotease RseP; Region: TIGR00054
568206002313	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
568206002314	active site
568206002315	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
568206002316	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
568206002317	protein binding site [polypeptide binding]; other site
568206002318	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
568206002319	putative substrate binding region [chemical binding]; other site
568206002320	prolyl-tRNA synthetase; Provisional; Region: PRK09194
568206002321	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
568206002322	dimer interface [polypeptide binding]; other site
568206002323	motif 1; other site
568206002324	active site
568206002325	motif 2; other site
568206002326	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
568206002327	putative deacylase active site [active]
568206002328	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
568206002329	active site
568206002330	motif 3; other site
568206002331	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
568206002332	anticodon binding site; other site
568206002333	DNA polymerase III PolC; Validated; Region: polC; PRK00448
568206002334	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
568206002335	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
568206002336	generic binding surface II; other site
568206002337	generic binding surface I; other site
568206002338	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
568206002339	active site
568206002340	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
568206002341	active site
568206002342	catalytic site [active]
568206002343	substrate binding site [chemical binding]; other site
568206002344	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
568206002345	ribosome maturation protein RimP; Reviewed; Region: PRK00092
568206002346	Sm and related proteins; Region: Sm_like; cl00259
568206002347	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
568206002348	putative oligomer interface [polypeptide binding]; other site
568206002349	putative RNA binding site [nucleotide binding]; other site
568206002350	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
568206002351	NusA N-terminal domain; Region: NusA_N; pfam08529
568206002352	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
568206002353	RNA binding site [nucleotide binding]; other site
568206002354	homodimer interface [polypeptide binding]; other site
568206002355	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
568206002356	G-X-X-G motif; other site
568206002357	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
568206002358	G-X-X-G motif; other site
568206002359	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
568206002360	putative RNA binding cleft [nucleotide binding]; other site
568206002361	hypothetical protein; Provisional; Region: PRK07714
568206002362	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
568206002363	translation initiation factor IF-2; Region: IF-2; TIGR00487
568206002364	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
568206002365	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
568206002366	G1 box; other site
568206002367	putative GEF interaction site [polypeptide binding]; other site
568206002368	GTP/Mg2+ binding site [chemical binding]; other site
568206002369	Switch I region; other site
568206002370	G2 box; other site
568206002371	G3 box; other site
568206002372	Switch II region; other site
568206002373	G4 box; other site
568206002374	G5 box; other site
568206002375	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
568206002376	Translation-initiation factor 2; Region: IF-2; pfam11987
568206002377	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
568206002378	Protein of unknown function (DUF503); Region: DUF503; pfam04456
568206002379	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
568206002380	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
568206002381	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
568206002382	RNA binding site [nucleotide binding]; other site
568206002383	active site
568206002384	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
568206002385	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
568206002386	active site
568206002387	Riboflavin kinase; Region: Flavokinase; smart00904
568206002388	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
568206002389	16S/18S rRNA binding site [nucleotide binding]; other site
568206002390	S13e-L30e interaction site [polypeptide binding]; other site
568206002391	25S rRNA binding site [nucleotide binding]; other site
568206002392	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
568206002393	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
568206002394	RNase E interface [polypeptide binding]; other site
568206002395	trimer interface [polypeptide binding]; other site
568206002396	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
568206002397	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
568206002398	RNase E interface [polypeptide binding]; other site
568206002399	trimer interface [polypeptide binding]; other site
568206002400	active site
568206002401	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
568206002402	putative nucleic acid binding region [nucleotide binding]; other site
568206002403	G-X-X-G motif; other site
568206002404	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
568206002405	RNA binding site [nucleotide binding]; other site
568206002406	domain interface; other site
568206002407	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
568206002408	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
568206002409	NodB motif; other site
568206002410	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
568206002411	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
568206002412	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
568206002413	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
568206002414	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
568206002415	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
568206002416	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
568206002417	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
568206002418	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
568206002419	aspartate kinase I; Reviewed; Region: PRK08210
568206002420	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
568206002421	nucleotide binding site [chemical binding]; other site
568206002422	substrate binding site [chemical binding]; other site
568206002423	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
568206002424	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
568206002425	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
568206002426	dihydrodipicolinate synthase; Region: dapA; TIGR00674
568206002427	dimer interface [polypeptide binding]; other site
568206002428	active site
568206002429	catalytic residue [active]
568206002430	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
568206002431	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206002432	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
568206002433	Clp protease; Region: CLP_protease; pfam00574
568206002434	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
568206002435	active site
568206002436	YlzJ-like protein; Region: YlzJ; pfam14035
568206002437	Tetraspanin family; Region: Tetraspannin; pfam00335
568206002438	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
568206002439	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568206002440	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
568206002441	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568206002442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206002443	DNA-binding site [nucleotide binding]; DNA binding site
568206002444	UTRA domain; Region: UTRA; pfam07702
568206002445	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
568206002446	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
568206002447	ligand binding site [chemical binding]; other site
568206002448	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
568206002449	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
568206002450	Walker A/P-loop; other site
568206002451	ATP binding site [chemical binding]; other site
568206002452	Q-loop/lid; other site
568206002453	ABC transporter signature motif; other site
568206002454	Walker B; other site
568206002455	D-loop; other site
568206002456	H-loop/switch region; other site
568206002457	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
568206002458	potential frameshift: common BLAST hit: gi|225865770|ref|YP_002751148.1| sugar ABC transporter, permease protein
568206002459	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603
568206002460	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
568206002461	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
568206002462	TM-ABC transporter signature motif; other site
568206002463	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
568206002464	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
568206002465	TM-ABC transporter signature motif; other site
568206002466	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
568206002467	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
568206002468	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
568206002469	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
568206002470	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
568206002471	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
568206002472	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206002473	NAD(P) binding site [chemical binding]; other site
568206002474	active site
568206002475	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
568206002476	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
568206002477	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
568206002478	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
568206002479	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206002480	non-specific DNA binding site [nucleotide binding]; other site
568206002481	salt bridge; other site
568206002482	sequence-specific DNA binding site [nucleotide binding]; other site
568206002483	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
568206002484	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
568206002485	competence damage-inducible protein A; Provisional; Region: PRK00549
568206002486	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
568206002487	putative MPT binding site; other site
568206002488	Competence-damaged protein; Region: CinA; pfam02464
568206002489	recA bacterial DNA recombination protein; Region: RecA; cl17211
568206002490	recA bacterial DNA recombination protein; Region: RecA; cl17211
568206002491	phosphodiesterase; Provisional; Region: PRK12704
568206002492	Uncharacterized conserved protein [Function unknown]; Region: COG3334
568206002493	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206002494	Zn2+ binding site [ion binding]; other site
568206002495	Mg2+ binding site [ion binding]; other site
568206002496	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
568206002497	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206002498	putative active site [active]
568206002499	metal binding site [ion binding]; metal-binding site
568206002500	homodimer binding site [polypeptide binding]; other site
568206002501	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
568206002502	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
568206002503	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
568206002504	active site
568206002505	dimer interface [polypeptide binding]; other site
568206002506	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
568206002507	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
568206002508	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
568206002509	dimer interface [polypeptide binding]; other site
568206002510	PYR/PP interface [polypeptide binding]; other site
568206002511	TPP binding site [chemical binding]; other site
568206002512	substrate binding site [chemical binding]; other site
568206002513	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568206002514	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
568206002515	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
568206002516	TPP-binding site [chemical binding]; other site
568206002517	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
568206002518	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
568206002519	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
568206002520	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206002521	FeS/SAM binding site; other site
568206002522	TRAM domain; Region: TRAM; pfam01938
568206002523	Predicted membrane protein [Function unknown]; Region: COG4550
568206002524	Outer spore coat protein E (CotE); Region: CotE; pfam10628
568206002525	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
568206002526	MutS domain I; Region: MutS_I; pfam01624
568206002527	MutS domain II; Region: MutS_II; pfam05188
568206002528	MutS domain III; Region: MutS_III; pfam05192
568206002529	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
568206002530	Walker A/P-loop; other site
568206002531	ATP binding site [chemical binding]; other site
568206002532	Q-loop/lid; other site
568206002533	ABC transporter signature motif; other site
568206002534	Walker B; other site
568206002535	D-loop; other site
568206002536	H-loop/switch region; other site
568206002537	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
568206002538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206002539	ATP binding site [chemical binding]; other site
568206002540	Mg2+ binding site [ion binding]; other site
568206002541	G-X-G motif; other site
568206002542	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
568206002543	ATP binding site [chemical binding]; other site
568206002544	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
568206002545	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
568206002546	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
568206002547	Walker A/P-loop; other site
568206002548	ATP binding site [chemical binding]; other site
568206002549	Q-loop/lid; other site
568206002550	ABC transporter signature motif; other site
568206002551	Walker B; other site
568206002552	D-loop; other site
568206002553	H-loop/switch region; other site
568206002554	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
568206002555	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568206002556	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
568206002557	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568206002558	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206002559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206002560	active site
568206002561	phosphorylation site [posttranslational modification]
568206002562	intermolecular recognition site; other site
568206002563	dimerization interface [polypeptide binding]; other site
568206002564	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206002565	DNA binding site [nucleotide binding]
568206002566	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206002567	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206002568	dimer interface [polypeptide binding]; other site
568206002569	phosphorylation site [posttranslational modification]
568206002570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206002571	ATP binding site [chemical binding]; other site
568206002572	Mg2+ binding site [ion binding]; other site
568206002573	G-X-G motif; other site
568206002574	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
568206002575	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
568206002576	active site
568206002577	Tetratricopeptide repeat; Region: TPR_16; pfam13432
568206002578	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206002579	binding surface
568206002580	TPR motif; other site
568206002581	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
568206002582	G1 box; other site
568206002583	GTP/Mg2+ binding site [chemical binding]; other site
568206002584	Switch I region; other site
568206002585	G3 box; other site
568206002586	Switch II region; other site
568206002587	G4 box; other site
568206002588	G5 box; other site
568206002589	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
568206002590	Sulfatase; Region: Sulfatase; pfam00884
568206002591	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
568206002592	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568206002593	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568206002594	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
568206002595	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568206002596	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
568206002597	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
568206002598	putative active site [active]
568206002599	putative catalytic triad [active]
568206002600	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
568206002601	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
568206002602	active site
568206002603	catalytic site [active]
568206002604	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
568206002605	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206002606	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
568206002607	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568206002608	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206002609	DNA-binding site [nucleotide binding]; DNA binding site
568206002610	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206002611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206002612	homodimer interface [polypeptide binding]; other site
568206002613	catalytic residue [active]
568206002614	holin-like protein; Validated; Region: PRK01658
568206002615	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
568206002616	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
568206002617	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
568206002618	PAS domain S-box; Region: sensory_box; TIGR00229
568206002619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206002620	putative active site [active]
568206002621	heme pocket [chemical binding]; other site
568206002622	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568206002623	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206002624	metal binding site [ion binding]; metal-binding site
568206002625	active site
568206002626	I-site; other site
568206002627	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568206002628	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206002629	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568206002630	active site
568206002631	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206002632	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568206002633	catalytic core [active]
568206002634	hypothetical protein; Provisional; Region: PRK06764
568206002635	Predicted membrane protein [Function unknown]; Region: COG2364
568206002636	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206002637	peptidase T; Region: peptidase-T; TIGR01882
568206002638	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
568206002639	metal binding site [ion binding]; metal-binding site
568206002640	dimer interface [polypeptide binding]; other site
568206002641	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
568206002642	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568206002643	endonuclease III; Region: ENDO3c; smart00478
568206002644	minor groove reading motif; other site
568206002645	helix-hairpin-helix signature motif; other site
568206002646	substrate binding pocket [chemical binding]; other site
568206002647	active site
568206002648	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
568206002649	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568206002650	DNA binding site [nucleotide binding]
568206002651	active site
568206002652	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
568206002653	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
568206002654	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206002655	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206002656	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
568206002657	active site
568206002658	putative catalytic site [active]
568206002659	DNA binding site [nucleotide binding]
568206002660	putative phosphate binding site [ion binding]; other site
568206002661	metal binding site A [ion binding]; metal-binding site
568206002662	AP binding site [nucleotide binding]; other site
568206002663	metal binding site B [ion binding]; metal-binding site
568206002664	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
568206002665	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568206002666	putative ligand binding residues [chemical binding]; other site
568206002667	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
568206002668	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206002669	ABC-ATPase subunit  interface; other site
568206002670	dimer interface [polypeptide binding]; other site
568206002671	putative PBP binding regions; other site
568206002672	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
568206002673	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206002674	ABC-ATPase subunit  interface; other site
568206002675	dimer interface [polypeptide binding]; other site
568206002676	putative PBP binding regions; other site
568206002677	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568206002678	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568206002679	Walker A/P-loop; other site
568206002680	ATP binding site [chemical binding]; other site
568206002681	Q-loop/lid; other site
568206002682	ABC transporter signature motif; other site
568206002683	Walker B; other site
568206002684	D-loop; other site
568206002685	H-loop/switch region; other site
568206002686	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
568206002687	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
568206002688	putative homodimer interface [polypeptide binding]; other site
568206002689	putative homotetramer interface [polypeptide binding]; other site
568206002690	putative allosteric switch controlling residues; other site
568206002691	putative metal binding site [ion binding]; other site
568206002692	putative homodimer-homodimer interface [polypeptide binding]; other site
568206002693	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
568206002694	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
568206002695	metal-binding site [ion binding]
568206002696	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
568206002697	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
568206002698	metal-binding site [ion binding]
568206002699	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
568206002700	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
568206002701	metal-binding site [ion binding]
568206002702	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568206002703	Soluble P-type ATPase [General function prediction only]; Region: COG4087
568206002704	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
568206002705	IHF dimer interface [polypeptide binding]; other site
568206002706	IHF - DNA interface [nucleotide binding]; other site
568206002707	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
568206002708	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
568206002709	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206002710	putative active site [active]
568206002711	putative metal binding site [ion binding]; other site
568206002712	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
568206002713	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
568206002714	Glyco_18 domain; Region: Glyco_18; smart00636
568206002715	putative active site [active]
568206002716	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
568206002717	Predicted membrane protein [Function unknown]; Region: COG2322
568206002718	potential frameshift: common BLAST hit: gi|49478340|ref|YP_037785.1| NADH-dependent butanol dehydrogenase A
568206002719	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
568206002720	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
568206002721	active site
568206002722	metal binding site [ion binding]; metal-binding site
568206002723	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568206002724	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
568206002725	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568206002726	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
568206002727	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
568206002728	putative substrate binding site [chemical binding]; other site
568206002729	putative ATP binding site [chemical binding]; other site
568206002730	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
568206002731	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568206002732	active site
568206002733	phosphorylation site [posttranslational modification]
568206002734	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
568206002735	active site
568206002736	P-loop; other site
568206002737	phosphorylation site [posttranslational modification]
568206002738	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
568206002739	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206002740	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206002741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
568206002742	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
568206002743	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
568206002744	bacterial Hfq-like; Region: Hfq; cd01716
568206002745	hexamer interface [polypeptide binding]; other site
568206002746	Sm1 motif; other site
568206002747	RNA binding site [nucleotide binding]; other site
568206002748	Sm2 motif; other site
568206002749	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
568206002750	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
568206002751	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
568206002752	active site
568206002753	catalytic residues [active]
568206002754	DNA binding site [nucleotide binding]
568206002755	Int/Topo IB signature motif; other site
568206002756	stage V sporulation protein K; Region: spore_V_K; TIGR02881
568206002757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206002758	Walker A motif; other site
568206002759	ATP binding site [chemical binding]; other site
568206002760	Walker B motif; other site
568206002761	arginine finger; other site
568206002762	Predicted membrane protein [Function unknown]; Region: COG2860
568206002763	UPF0126 domain; Region: UPF0126; pfam03458
568206002764	UPF0126 domain; Region: UPF0126; pfam03458
568206002765	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
568206002766	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
568206002767	HflX GTPase family; Region: HflX; cd01878
568206002768	G1 box; other site
568206002769	GTP/Mg2+ binding site [chemical binding]; other site
568206002770	Switch I region; other site
568206002771	G2 box; other site
568206002772	G3 box; other site
568206002773	Switch II region; other site
568206002774	G4 box; other site
568206002775	G5 box; other site
568206002776	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
568206002777	Aluminium resistance protein; Region: Alum_res; pfam06838
568206002778	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
568206002779	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206002780	DNA binding residues [nucleotide binding]
568206002781	glutamine synthetase, type I; Region: GlnA; TIGR00653
568206002782	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
568206002783	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
568206002784	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
568206002785	Int/Topo IB signature motif; other site
568206002786	Domain of unknown function (DUF955); Region: DUF955; cl01076
568206002787	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
568206002788	ORF6C domain; Region: ORF6C; pfam10552
568206002789	Domain of unknown function (DUF771); Region: DUF771; pfam05595
568206002790	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
568206002791	Protein of unknown function (DUF1071); Region: DUF1071; pfam06378
568206002792	phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220
568206002793	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206002794	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
568206002795	Walker A motif; other site
568206002796	ATP binding site [chemical binding]; other site
568206002797	Walker B motif; other site
568206002798	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
568206002799	dUTPase; Region: dUTPase_2; pfam08761
568206002800	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
568206002801	active site
568206002802	homodimer interface [polypeptide binding]; other site
568206002803	metal binding site [ion binding]; metal-binding site
568206002804	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
568206002805	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
568206002806	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
568206002807	cofactor binding site; other site
568206002808	DNA binding site [nucleotide binding]
568206002809	substrate interaction site [chemical binding]; other site
568206002810	thymidylate synthase, flavin-dependent; Region: thyX; TIGR02170
568206002811	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
568206002812	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
568206002813	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
568206002814	PGAP1-like protein; Region: PGAP1; pfam07819
568206002815	positive control sigma-like factor; Validated; Region: PRK06930
568206002816	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206002817	DNA binding residues [nucleotide binding]
568206002818	AIPR protein; Region: AIPR; pfam10592
568206002819	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206002820	sequence-specific DNA binding site [nucleotide binding]; other site
568206002821	salt bridge; other site
568206002822	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
568206002823	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
568206002824	active site
568206002825	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
568206002826	homodimer interface [polypeptide binding]; other site
568206002827	chemical substrate binding site [chemical binding]; other site
568206002828	oligomer interface [polypeptide binding]; other site
568206002829	metal binding site [ion binding]; metal-binding site
568206002830	HNH endonuclease; Region: HNH_2; pfam13391
568206002831	Helix-turn-helix domain; Region: HTH_17; pfam12728
568206002832	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
568206002833	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
568206002834	Phage portal protein; Region: Phage_portal; pfam04860
568206002835	Phage-related protein [Function unknown]; Region: COG4695; cl01923
568206002836	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
568206002837	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
568206002838	Phage capsid family; Region: Phage_capsid; pfam05065
568206002839	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
568206002840	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
568206002841	DsrH like protein; Region: DsrH; cl17347
568206002842	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
568206002843	Phage-related minor tail protein [Function unknown]; Region: COG5280
568206002844	Phage-related protein [Function unknown]; Region: COG5412
568206002845	membrane protein P6; Region: PHA01399
568206002846	putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633
568206002847	Phage tail protein; Region: Sipho_tail; cl17486
568206002848	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
568206002849	gp58-like protein; Region: Gp58; pfam07902
568206002850	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
568206002851	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
568206002852	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
568206002853	amidase catalytic site [active]
568206002854	Zn binding residues [ion binding]; other site
568206002855	substrate binding site [chemical binding]; other site
568206002856	Bacterial SH3 domain; Region: SH3_3; cl17532
568206002857	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206002858	Helix-turn-helix domain; Region: HTH_17; pfam12728
568206002859	Helix-turn-helix domain; Region: HTH_17; pfam12728
568206002860	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206002861	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206002862	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568206002863	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
568206002864	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
568206002865	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
568206002866	LexA repressor; Validated; Region: PRK00215
568206002867	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206002868	putative DNA binding site [nucleotide binding]; other site
568206002869	putative Zn2+ binding site [ion binding]; other site
568206002870	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
568206002871	Catalytic site [active]
568206002872	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
568206002873	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
568206002874	catalytic residues [active]
568206002875	catalytic nucleophile [active]
568206002876	hypothetical protein; Provisional; Region: PRK01546
568206002877	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568206002878	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
568206002879	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206002880	active site
568206002881	metal binding site [ion binding]; metal-binding site
568206002882	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
568206002883	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568206002884	membrane-bound complex binding site; other site
568206002885	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
568206002886	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
568206002887	Walker A/P-loop; other site
568206002888	ATP binding site [chemical binding]; other site
568206002889	Q-loop/lid; other site
568206002890	ABC transporter signature motif; other site
568206002891	Walker B; other site
568206002892	D-loop; other site
568206002893	H-loop/switch region; other site
568206002894	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
568206002895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206002896	dimer interface [polypeptide binding]; other site
568206002897	conserved gate region; other site
568206002898	ABC-ATPase subunit interface; other site
568206002899	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
568206002900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206002901	dimer interface [polypeptide binding]; other site
568206002902	conserved gate region; other site
568206002903	ABC-ATPase subunit interface; other site
568206002904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
568206002905	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
568206002906	Probable transposase; Region: OrfB_IS605; pfam01385
568206002907	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
568206002908	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568206002909	TPP-binding site [chemical binding]; other site
568206002910	dimer interface [polypeptide binding]; other site
568206002911	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568206002912	PYR/PP interface [polypeptide binding]; other site
568206002913	dimer interface [polypeptide binding]; other site
568206002914	TPP binding site [chemical binding]; other site
568206002915	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568206002916	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
568206002917	hypothetical protein; Provisional; Region: PRK01844
568206002918	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206002919	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
568206002920	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206002921	Walker A/P-loop; other site
568206002922	ATP binding site [chemical binding]; other site
568206002923	Q-loop/lid; other site
568206002924	ABC transporter signature motif; other site
568206002925	Walker B; other site
568206002926	D-loop; other site
568206002927	H-loop/switch region; other site
568206002928	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568206002929	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206002930	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
568206002931	Walker A/P-loop; other site
568206002932	ATP binding site [chemical binding]; other site
568206002933	Q-loop/lid; other site
568206002934	ABC transporter signature motif; other site
568206002935	Walker B; other site
568206002936	D-loop; other site
568206002937	H-loop/switch region; other site
568206002938	Nuclease-related domain; Region: NERD; pfam08378
568206002939	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
568206002940	amidase catalytic site [active]
568206002941	Zn binding residues [ion binding]; other site
568206002942	substrate binding site [chemical binding]; other site
568206002943	S-layer homology domain; Region: SLH; pfam00395
568206002944	S-layer homology domain; Region: SLH; pfam00395
568206002945	S-layer homology domain; Region: SLH; pfam00395
568206002946	potential frameshift: common BLAST hit: gi|118478909|ref|YP_896060.1| permease
568206002947	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
568206002948	Domain of unknown function (DUF3903); Region: DUF3903; pfam13043
568206002949	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
568206002950	nudix motif; other site
568206002951	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
568206002952	holin-like protein; Validated; Region: PRK01658
568206002953	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
568206002954	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206002955	The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452
568206002956	putative dimerization interface [polypeptide binding]; other site
568206002957	putative substrate binding pocket [chemical binding]; other site
568206002958	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
568206002959	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
568206002960	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
568206002961	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002962	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002963	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002964	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002965	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002966	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002967	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002968	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002969	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002970	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002971	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002972	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002973	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002974	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002975	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002976	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002977	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206002978	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
568206002979	AAA domain; Region: AAA_28; pfam13521
568206002980	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
568206002981	active site
568206002982	DJ-1 family protein; Region: not_thiJ; TIGR01383
568206002983	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
568206002984	conserved cys residue [active]
568206002985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206002986	S-adenosylmethionine binding site [chemical binding]; other site
568206002987	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
568206002988	hexamer interface [polypeptide binding]; other site
568206002989	RNA binding site [nucleotide binding]; other site
568206002990	Histidine-zinc binding site [chemical binding]; other site
568206002991	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
568206002992	active sites [active]
568206002993	tetramer interface [polypeptide binding]; other site
568206002994	urocanate hydratase; Provisional; Region: PRK05414
568206002995	imidazolonepropionase; Validated; Region: PRK09356
568206002996	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
568206002997	active site
568206002998	agmatinase; Region: agmatinase; TIGR01230
568206002999	Agmatinase-like family; Region: Agmatinase-like; cd09990
568206003000	active site
568206003001	oligomer interface [polypeptide binding]; other site
568206003002	Mn binding site [ion binding]; other site
568206003003	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
568206003004	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
568206003005	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
568206003006	FMN binding site [chemical binding]; other site
568206003007	active site
568206003008	substrate binding site [chemical binding]; other site
568206003009	catalytic residue [active]
568206003010	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
568206003011	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
568206003012	active site
568206003013	FMN binding site [chemical binding]; other site
568206003014	substrate binding site [chemical binding]; other site
568206003015	3Fe-4S cluster binding site [ion binding]; other site
568206003016	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
568206003017	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
568206003018	Na binding site [ion binding]; other site
568206003019	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568206003020	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206003021	Zn binding site [ion binding]; other site
568206003022	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568206003023	Zn binding site [ion binding]; other site
568206003024	Predicted esterase [General function prediction only]; Region: COG0400
568206003025	putative hydrolase; Provisional; Region: PRK11460
568206003026	PAS domain S-box; Region: sensory_box; TIGR00229
568206003027	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206003028	putative active site [active]
568206003029	heme pocket [chemical binding]; other site
568206003030	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
568206003031	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206003032	putative active site [active]
568206003033	heme pocket [chemical binding]; other site
568206003034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206003035	dimer interface [polypeptide binding]; other site
568206003036	phosphorylation site [posttranslational modification]
568206003037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206003038	ATP binding site [chemical binding]; other site
568206003039	Mg2+ binding site [ion binding]; other site
568206003040	G-X-G motif; other site
568206003041	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206003042	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
568206003043	dimer interface [polypeptide binding]; other site
568206003044	putative metal binding site [ion binding]; other site
568206003045	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206003046	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206003047	active site
568206003048	Protein phosphatase 2C; Region: PP2C_2; pfam13672
568206003049	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
568206003050	amidase catalytic site [active]
568206003051	Zn binding residues [ion binding]; other site
568206003052	substrate binding site [chemical binding]; other site
568206003053	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
568206003054	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
568206003055	active site
568206003056	catalytic motif [active]
568206003057	Zn binding site [ion binding]; other site
568206003058	S-layer homology domain; Region: SLH; pfam00395
568206003059	S-layer homology domain; Region: SLH; pfam00395
568206003060	S-layer homology domain; Region: SLH; pfam00395
568206003061	GCN5-related N-acetyltransferases (GNAT) represent a large superfamily of functionally diverse enzymes that catalyze the transfer of an acetyl group from acetyl-Coenzyme A to the primary amine of a wide range of acceptor substrates. Members of this...; Region: GNAT; cl00443
568206003062	Coenzyme A binding pocket; other site
568206003063	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
568206003064	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
568206003065	dimer interface [polypeptide binding]; other site
568206003066	acyl-activating enzyme (AAE) consensus motif; other site
568206003067	putative active site [active]
568206003068	AMP binding site [chemical binding]; other site
568206003069	putative CoA binding site [chemical binding]; other site
568206003070	BioY family; Region: BioY; pfam02632
568206003071	acyl-CoA synthetase; Validated; Region: PRK07638
568206003072	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206003073	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206003074	acyl-activating enzyme (AAE) consensus motif; other site
568206003075	acyl-activating enzyme (AAE) consensus motif; other site
568206003076	AMP binding site [chemical binding]; other site
568206003077	active site
568206003078	CoA binding site [chemical binding]; other site
568206003079	acetyl-CoA acetyltransferase; Provisional; Region: PRK06690
568206003080	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
568206003081	dimer interface [polypeptide binding]; other site
568206003082	active site
568206003083	SAP domain; Region: SAP; pfam02037
568206003084	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
568206003085	nudix motif; other site
568206003086	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
568206003087	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
568206003088	BT1 family; Region: BT1; pfam03092
568206003089	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
568206003090	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
568206003091	putative dimer interface [polypeptide binding]; other site
568206003092	Small acid-soluble spore protein P family; Region: SspP; cl12105
568206003093	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568206003094	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
568206003095	NodB motif; other site
568206003096	active site
568206003097	catalytic site [active]
568206003098	metal binding site [ion binding]; metal-binding site
568206003099	acid-soluble spore protein O; Provisional; Region: sspO; PRK02984
568206003100	aconitate hydratase; Validated; Region: PRK09277
568206003101	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
568206003102	substrate binding site [chemical binding]; other site
568206003103	ligand binding site [chemical binding]; other site
568206003104	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
568206003105	substrate binding site [chemical binding]; other site
568206003106	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568206003107	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206003108	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206003109	Walker A/P-loop; other site
568206003110	ATP binding site [chemical binding]; other site
568206003111	Q-loop/lid; other site
568206003112	ABC transporter signature motif; other site
568206003113	Walker B; other site
568206003114	D-loop; other site
568206003115	H-loop/switch region; other site
568206003116	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
568206003117	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
568206003118	catalytic residues [active]
568206003119	DNA polymerase III subunit epsilon; Validated; Region: PRK06807
568206003120	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
568206003121	active site
568206003122	catalytic site [active]
568206003123	substrate binding site [chemical binding]; other site
568206003124	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
568206003125	acid-soluble spore protein N; Provisional; Region: sspN; PRK09398
568206003126	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
568206003127	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
568206003128	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568206003129	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568206003130	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
568206003131	active site
568206003132	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
568206003133	active site
568206003134	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
568206003135	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
568206003136	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
568206003137	Class III ribonucleotide reductase; Region: RNR_III; cd01675
568206003138	effector binding site; other site
568206003139	active site
568206003140	Zn binding site [ion binding]; other site
568206003141	glycine loop; other site
568206003142	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
568206003143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206003144	FeS/SAM binding site; other site
568206003145	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206003146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206003147	active site
568206003148	phosphorylation site [posttranslational modification]
568206003149	intermolecular recognition site; other site
568206003150	dimerization interface [polypeptide binding]; other site
568206003151	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206003152	DNA binding site [nucleotide binding]
568206003153	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
568206003154	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
568206003155	protein binding site [polypeptide binding]; other site
568206003156	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
568206003157	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
568206003158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206003159	ATP binding site [chemical binding]; other site
568206003160	Mg2+ binding site [ion binding]; other site
568206003161	G-X-G motif; other site
568206003162	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
568206003163	anchoring element; other site
568206003164	dimer interface [polypeptide binding]; other site
568206003165	ATP binding site [chemical binding]; other site
568206003166	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
568206003167	active site
568206003168	putative metal-binding site [ion binding]; other site
568206003169	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
568206003170	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
568206003171	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
568206003172	CAP-like domain; other site
568206003173	active site
568206003174	primary dimer interface [polypeptide binding]; other site
568206003175	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206003176	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206003177	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206003178	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568206003179	putative oxidoreductase; Provisional; Region: PRK11579
568206003180	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568206003181	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
568206003182	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206003183	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206003184	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206003185	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206003186	Walker A/P-loop; other site
568206003187	ATP binding site [chemical binding]; other site
568206003188	Q-loop/lid; other site
568206003189	ABC transporter signature motif; other site
568206003190	Walker B; other site
568206003191	D-loop; other site
568206003192	H-loop/switch region; other site
568206003193	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206003194	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206003195	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
568206003196	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206003197	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206003198	DNA binding residues [nucleotide binding]
568206003199	Transcriptional regulator [Transcription]; Region: LytR; COG1316
568206003200	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
568206003201	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
568206003202	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206003203	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206003204	peptide binding site [polypeptide binding]; other site
568206003205	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206003206	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206003207	peptide binding site [polypeptide binding]; other site
568206003208	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206003209	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206003210	peptide binding site [polypeptide binding]; other site
568206003211	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206003212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206003213	S-adenosylmethionine binding site [chemical binding]; other site
568206003214	O-methyltransferase; Region: Methyltransf_2; pfam00891
568206003215	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
568206003216	metal ion-dependent adhesion site (MIDAS); other site
568206003217	Tubulin like; Region: Tubulin_2; pfam13809
568206003218	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
568206003219	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
568206003220	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
568206003221	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
568206003222	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
568206003223	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
568206003224	catalytic loop [active]
568206003225	iron binding site [ion binding]; other site
568206003226	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
568206003227	4Fe-4S binding domain; Region: Fer4; pfam00037
568206003228	4Fe-4S binding domain; Region: Fer4; pfam00037
568206003229	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
568206003230	[4Fe-4S] binding site [ion binding]; other site
568206003231	molybdopterin cofactor binding site; other site
568206003232	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
568206003233	molybdopterin cofactor binding site; other site
568206003234	Uncharacterized conserved protein [Function unknown]; Region: COG2427
568206003235	Uncharacterized conserved protein [Function unknown]; Region: COG5609
568206003236	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
568206003237	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
568206003238	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206003239	FeS/SAM binding site; other site
568206003240	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
568206003241	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
568206003242	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
568206003243	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
568206003244	ATP binding site [chemical binding]; other site
568206003245	substrate interface [chemical binding]; other site
568206003246	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
568206003247	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
568206003248	dimer interface [polypeptide binding]; other site
568206003249	putative functional site; other site
568206003250	putative MPT binding site; other site
568206003251	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
568206003252	MoaE homodimer interface [polypeptide binding]; other site
568206003253	MoaD interaction [polypeptide binding]; other site
568206003254	active site residues [active]
568206003255	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
568206003256	MoaE interaction surface [polypeptide binding]; other site
568206003257	MoeB interaction surface [polypeptide binding]; other site
568206003258	thiocarboxylated glycine; other site
568206003259	antiporter inner membrane protein; Provisional; Region: PRK11670
568206003260	Domain of unknown function DUF59; Region: DUF59; pfam01883
568206003261	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
568206003262	Walker A motif; other site
568206003263	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
568206003264	Predicted permeases [General function prediction only]; Region: RarD; COG2962
568206003265	Divergent PAP2 family; Region: DUF212; pfam02681
568206003266	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
568206003267	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
568206003268	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
568206003269	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
568206003270	NAD(P) binding site [chemical binding]; other site
568206003271	homotetramer interface [polypeptide binding]; other site
568206003272	homodimer interface [polypeptide binding]; other site
568206003273	active site
568206003274	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
568206003275	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
568206003276	NAD(P) binding site [chemical binding]; other site
568206003277	catalytic residues [active]
568206003278	Protein of unknown function (DUF997); Region: DUF997; pfam06196
568206003279	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
568206003280	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
568206003281	Na binding site [ion binding]; other site
568206003282	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
568206003283	active site
568206003284	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206003285	potential frameshift: common BLAST hit: gi|49186348|ref|YP_029600.1| argininosuccinate lyase
568206003286	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
568206003287	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
568206003288	tetramer interface [polypeptide binding]; other site
568206003289	active sites [active]
568206003290	Predicted acetyltransferase [General function prediction only]; Region: COG3393
568206003291	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206003292	short chain dehydrogenase; Provisional; Region: PRK06924
568206003293	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
568206003294	NADP binding site [chemical binding]; other site
568206003295	homodimer interface [polypeptide binding]; other site
568206003296	active site
568206003297	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003298	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003299	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003300	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003301	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003302	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003303	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003304	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003305	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003306	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003307	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003308	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003309	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206003310	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
568206003311	trimer interface [polypeptide binding]; other site
568206003312	active site
568206003313	substrate binding site [chemical binding]; other site
568206003314	CoA binding site [chemical binding]; other site
568206003315	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
568206003316	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
568206003317	nudix motif; other site
568206003318	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
568206003319	flavodoxin; Provisional; Region: PRK06703
568206003320	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
568206003321	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568206003322	DNA-binding site [nucleotide binding]; DNA binding site
568206003323	RNA-binding motif; other site
568206003324	exonuclease; Provisional; Region: PRK06722
568206003325	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
568206003326	active site
568206003327	catalytic site [active]
568206003328	substrate binding site [chemical binding]; other site
568206003329	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
568206003330	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
568206003331	VanW like protein; Region: VanW; pfam04294
568206003332	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
568206003333	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
568206003334	putative metal binding site [ion binding]; other site
568206003335	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206003336	active site
568206003337	metal binding site [ion binding]; metal-binding site
568206003338	Predicted acetyltransferase [General function prediction only]; Region: COG3981
568206003339	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206003340	MgtC family; Region: MgtC; pfam02308
568206003341	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
568206003342	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
568206003343	FOG: PKD repeat [General function prediction only]; Region: COG3291
568206003344	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
568206003345	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
568206003346	enoyl-CoA hydratase; Provisional; Region: PRK06688
568206003347	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
568206003348	substrate binding site [chemical binding]; other site
568206003349	oxyanion hole (OAH) forming residues; other site
568206003350	trimer interface [polypeptide binding]; other site
568206003351	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
568206003352	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
568206003353	active site
568206003354	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568206003355	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206003356	active site
568206003357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206003358	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206003359	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
568206003360	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
568206003361	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
568206003362	inhibitor-cofactor binding pocket; inhibition site
568206003363	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206003364	catalytic residue [active]
568206003365	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
568206003366	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
568206003367	trimer interface [polypeptide binding]; other site
568206003368	active site
568206003369	substrate binding site [chemical binding]; other site
568206003370	CoA binding site [chemical binding]; other site
568206003371	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
568206003372	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206003373	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568206003374	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
568206003375	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
568206003376	FAD binding domain; Region: FAD_binding_4; pfam01565
568206003377	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
568206003378	Sodium Bile acid symporter family; Region: SBF; cl17470
568206003379	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
568206003380	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
568206003381	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
568206003382	potential frameshift: common BLAST hit: gi|218904640|ref|YP_002452474.1| putative response regulator
568206003383	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206003384	Uncharacterized conserved protein [Function unknown]; Region: COG0397
568206003385	hypothetical protein; Validated; Region: PRK00029
568206003386	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568206003387	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
568206003388	putative NAD(P) binding site [chemical binding]; other site
568206003389	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206003390	dimerization interface [polypeptide binding]; other site
568206003391	putative DNA binding site [nucleotide binding]; other site
568206003392	putative Zn2+ binding site [ion binding]; other site
568206003393	FAD binding domain; Region: FAD_binding_3; pfam01494
568206003394	hypothetical protein; Provisional; Region: PRK07236
568206003395	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
568206003396	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
568206003397	active site
568206003398	catalytic site [active]
568206003399	metal binding site [ion binding]; metal-binding site
568206003400	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568206003401	putative active site [active]
568206003402	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
568206003403	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206003404	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206003405	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
568206003406	putative dimerization interface [polypeptide binding]; other site
568206003407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206003408	putative substrate translocation pore; other site
568206003409	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206003410	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206003411	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206003412	oligoendopeptidase F; Region: pepF; TIGR00181
568206003413	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
568206003414	active site
568206003415	Zn binding site [ion binding]; other site
568206003416	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
568206003417	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
568206003418	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
568206003419	active site
568206003420	Na/Ca binding site [ion binding]; other site
568206003421	catalytic site [active]
568206003422	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
568206003423	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
568206003424	MutS domain III; Region: MutS_III; pfam05192
568206003425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206003426	Walker A/P-loop; other site
568206003427	ATP binding site [chemical binding]; other site
568206003428	Q-loop/lid; other site
568206003429	ABC transporter signature motif; other site
568206003430	Walker B; other site
568206003431	D-loop; other site
568206003432	H-loop/switch region; other site
568206003433	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206003434	Coenzyme A binding pocket [chemical binding]; other site
568206003435	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568206003436	catalytic core [active]
568206003437	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568206003438	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
568206003439	NADP binding site [chemical binding]; other site
568206003440	dimer interface [polypeptide binding]; other site
568206003441	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206003442	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206003443	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206003444	dimerization interface [polypeptide binding]; other site
568206003445	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
568206003446	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
568206003447	DinB family; Region: DinB; cl17821
568206003448	DinB superfamily; Region: DinB_2; pfam12867
568206003449	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
568206003450	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
568206003451	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
568206003452	Protein of unknown function (DUF817); Region: DUF817; pfam05675
568206003453	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206003454	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206003455	ABC-ATPase subunit  interface; other site
568206003456	dimer interface [polypeptide binding]; other site
568206003457	putative PBP binding regions; other site
568206003458	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
568206003459	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206003460	ABC-ATPase subunit  interface; other site
568206003461	dimer interface [polypeptide binding]; other site
568206003462	putative PBP binding regions; other site
568206003463	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
568206003464	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
568206003465	putative ligand binding residues [chemical binding]; other site
568206003466	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568206003467	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206003468	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206003469	Coenzyme A binding pocket [chemical binding]; other site
568206003470	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206003471	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
568206003472	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
568206003473	transmembrane helices; other site
568206003474	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
568206003475	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
568206003476	Haemolysin XhlA; Region: XhlA; pfam10779
568206003477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206003478	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
568206003479	putative substrate translocation pore; other site
568206003480	putative transport protein YifK; Provisional; Region: PRK10746
568206003481	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
568206003482	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
568206003483	putative NAD(P) binding site [chemical binding]; other site
568206003484	dimer interface [polypeptide binding]; other site
568206003485	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206003486	Protein of unknown function, DUF606; Region: DUF606; pfam04657
568206003487	Protein of unknown function, DUF606; Region: DUF606; pfam04657
568206003488	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
568206003489	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568206003490	ligand binding site [chemical binding]; other site
568206003491	flexible hinge region; other site
568206003492	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
568206003493	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
568206003494	dimer interface [polypeptide binding]; other site
568206003495	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206003496	ligand binding site [chemical binding]; other site
568206003497	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
568206003498	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
568206003499	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206003500	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206003501	hypothetical protein; Provisional; Region: PRK06771
568206003502	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
568206003503	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
568206003504	metal binding site [ion binding]; metal-binding site
568206003505	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
568206003506	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
568206003507	active site
568206003508	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206003509	hydroxylamine reductase; Provisional; Region: PRK12310
568206003510	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
568206003511	ACS interaction site; other site
568206003512	CODH interaction site; other site
568206003513	metal cluster binding site [ion binding]; other site
568206003514	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206003515	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568206003516	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
568206003517	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
568206003518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206003519	Walker A/P-loop; other site
568206003520	ATP binding site [chemical binding]; other site
568206003521	Q-loop/lid; other site
568206003522	ABC transporter signature motif; other site
568206003523	Walker B; other site
568206003524	D-loop; other site
568206003525	H-loop/switch region; other site
568206003526	ABC-2 type transporter; Region: ABC2_membrane; cl17235
568206003527	Protein of unknown function (DUF805); Region: DUF805; pfam05656
568206003528	Predicted transcriptional regulator [Transcription]; Region: COG2378
568206003529	HTH domain; Region: HTH_11; pfam08279
568206003530	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
568206003531	Protein of unknown function (DUF3963); Region: DUF3963; pfam13124
568206003532	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206003533	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206003534	CAAX protease self-immunity; Region: Abi; pfam02517
568206003535	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206003536	active site
568206003537	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
568206003538	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206003539	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
568206003540	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
568206003541	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
568206003542	active site
568206003543	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
568206003544	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
568206003545	NodB motif; other site
568206003546	putative active site [active]
568206003547	putative catalytic site [active]
568206003548	putative Zn binding site [ion binding]; other site
568206003549	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
568206003550	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
568206003551	DXD motif; other site
568206003552	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206003553	dimerization interface [polypeptide binding]; other site
568206003554	putative DNA binding site [nucleotide binding]; other site
568206003555	putative Zn2+ binding site [ion binding]; other site
568206003556	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
568206003557	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
568206003558	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
568206003559	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
568206003560	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
568206003561	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206003562	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206003563	dimerization interface [polypeptide binding]; other site
568206003564	putative DNA binding site [nucleotide binding]; other site
568206003565	putative Zn2+ binding site [ion binding]; other site
568206003566	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
568206003567	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
568206003568	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
568206003569	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206003570	acyl-activating enzyme (AAE) consensus motif; other site
568206003571	AMP binding site [chemical binding]; other site
568206003572	active site
568206003573	CoA binding site [chemical binding]; other site
568206003574	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206003575	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206003576	C factor cell-cell signaling protein; Provisional; Region: PRK09009
568206003577	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206003578	NAD(P) binding site [chemical binding]; other site
568206003579	active site
568206003580	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206003581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206003582	Coenzyme A binding pocket [chemical binding]; other site
568206003583	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
568206003584	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
568206003585	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
568206003586	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
568206003587	Phosphotransferase enzyme family; Region: APH; pfam01636
568206003588	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206003589	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
568206003590	putative hydrophobic ligand binding site [chemical binding]; other site
568206003591	protein interface [polypeptide binding]; other site
568206003592	gate; other site
568206003593	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206003594	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206003595	active site
568206003596	catalytic tetrad [active]
568206003597	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206003598	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206003599	dimerization interface [polypeptide binding]; other site
568206003600	putative DNA binding site [nucleotide binding]; other site
568206003601	putative Zn2+ binding site [ion binding]; other site
568206003602	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206003603	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
568206003604	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
568206003605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
568206003606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206003607	S-adenosylmethionine binding site [chemical binding]; other site
568206003608	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568206003609	putative oxidoreductase; Provisional; Region: PRK10206
568206003610	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
568206003611	potential frameshift: common BLAST hit: gi|49186209|ref|YP_029461.1| GntR family transcriptional regulator
568206003612	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206003613	DNA-binding site [nucleotide binding]; DNA binding site
568206003614	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568206003615	UTRA domain; Region: UTRA; pfam07702
568206003616	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206003617	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206003618	dimerization interface [polypeptide binding]; other site
568206003619	putative DNA binding site [nucleotide binding]; other site
568206003620	putative Zn2+ binding site [ion binding]; other site
568206003621	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
568206003622	ArsC family; Region: ArsC; pfam03960
568206003623	putative catalytic residues [active]
568206003624	thiol/disulfide switch; other site
568206003625	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
568206003626	Transcriptional regulator; Region: Rrf2; pfam02082
568206003627	Rrf2 family protein; Region: rrf2_super; TIGR00738
568206003628	IDEAL domain; Region: IDEAL; pfam08858
568206003629	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
568206003630	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
568206003631	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206003632	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568206003633	active site
568206003634	metal binding site [ion binding]; metal-binding site
568206003635	hypothetical protein; Provisional; Region: PRK02487
568206003636	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
568206003637	active site 1 [active]
568206003638	dimer interface [polypeptide binding]; other site
568206003639	hexamer interface [polypeptide binding]; other site
568206003640	active site 2 [active]
568206003641	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
568206003642	hexamer interface [polypeptide binding]; other site
568206003643	active site 2 [active]
568206003644	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568206003645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206003646	putative substrate translocation pore; other site
568206003647	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206003648	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206003649	active site
568206003650	catalytic tetrad [active]
568206003651	BNR repeat-like domain; Region: BNR_2; pfam13088
568206003652	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
568206003653	dimer interface [polypeptide binding]; other site
568206003654	FMN binding site [chemical binding]; other site
568206003655	Viral enhancin protein; Region: Enhancin; pfam03272
568206003656	Peptidase M60-like family; Region: M60-like; pfam13402
568206003657	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
568206003658	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
568206003659	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
568206003660	active site
568206003661	Zn binding site [ion binding]; other site
568206003662	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
568206003663	classical (c) SDRs; Region: SDR_c; cd05233
568206003664	NAD(P) binding site [chemical binding]; other site
568206003665	active site
568206003666	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
568206003667	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568206003668	putative NAD(P) binding site [chemical binding]; other site
568206003669	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
568206003670	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
568206003671	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568206003672	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
568206003673	putative NAD(P) binding site [chemical binding]; other site
568206003674	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
568206003675	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
568206003676	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
568206003677	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
568206003678	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
568206003679	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568206003680	TPP-binding site [chemical binding]; other site
568206003681	dimer interface [polypeptide binding]; other site
568206003682	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568206003683	PYR/PP interface [polypeptide binding]; other site
568206003684	dimer interface [polypeptide binding]; other site
568206003685	TPP binding site [chemical binding]; other site
568206003686	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568206003687	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
568206003688	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
568206003689	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
568206003690	active site
568206003691	intersubunit interactions; other site
568206003692	catalytic residue [active]
568206003693	GntP family permease; Region: GntP_permease; pfam02447
568206003694	fructuronate transporter; Provisional; Region: PRK10034; cl15264
568206003695	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
568206003696	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
568206003697	N- and C-terminal domain interface [polypeptide binding]; other site
568206003698	active site
568206003699	catalytic site [active]
568206003700	metal binding site [ion binding]; metal-binding site
568206003701	carbohydrate binding site [chemical binding]; other site
568206003702	ATP binding site [chemical binding]; other site
568206003703	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
568206003704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
568206003705	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
568206003706	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
568206003707	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
568206003708	EamA-like transporter family; Region: EamA; pfam00892
568206003709	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
568206003710	EamA-like transporter family; Region: EamA; pfam00892
568206003711	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
568206003712	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568206003713	DNA binding residues [nucleotide binding]
568206003714	putative dimer interface [polypeptide binding]; other site
568206003715	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568206003716	Domain of unknown function DUF21; Region: DUF21; pfam01595
568206003717	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568206003718	Transporter associated domain; Region: CorC_HlyC; smart01091
568206003719	ATP synthase I chain; Region: ATP_synt_I; cl09170
568206003720	hypothetical protein; Provisional; Region: PRK04164
568206003721	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206003722	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
568206003723	Tetratricopeptide repeat; Region: TPR_16; pfam13432
568206003724	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206003725	TPR motif; other site
568206003726	binding surface
568206003727	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
568206003728	binding surface
568206003729	TPR motif; other site
568206003730	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206003731	multidrug resistance protein MdtH; Provisional; Region: PRK11646
568206003732	putative substrate translocation pore; other site
568206003733	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
568206003734	CGNR zinc finger; Region: zf-CGNR; pfam11706
568206003735	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206003736	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206003737	S-adenosylmethionine binding site [chemical binding]; other site
568206003738	ydaO/yuaA leader
568206003739	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206003740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206003741	Coenzyme A binding pocket [chemical binding]; other site
568206003742	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568206003743	Domain of unknown function DUF20; Region: UPF0118; pfam01594
568206003744	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464
568206003745	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
568206003746	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
568206003747	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
568206003748	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
568206003749	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
568206003750	active site
568206003751	HIGH motif; other site
568206003752	dimer interface [polypeptide binding]; other site
568206003753	KMSKS motif; other site
568206003754	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206003755	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206003756	Walker A/P-loop; other site
568206003757	ATP binding site [chemical binding]; other site
568206003758	Q-loop/lid; other site
568206003759	ABC transporter signature motif; other site
568206003760	Walker B; other site
568206003761	D-loop; other site
568206003762	H-loop/switch region; other site
568206003763	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568206003764	FtsX-like permease family; Region: FtsX; pfam02687
568206003765	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568206003766	FtsX-like permease family; Region: FtsX; pfam02687
568206003767	maltose O-acetyltransferase; Provisional; Region: PRK10092
568206003768	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
568206003769	active site
568206003770	substrate binding site [chemical binding]; other site
568206003771	trimer interface [polypeptide binding]; other site
568206003772	CoA binding site [chemical binding]; other site
568206003773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206003774	putative substrate translocation pore; other site
568206003775	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206003776	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568206003777	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568206003778	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
568206003779	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206003780	putative metal binding site [ion binding]; other site
568206003781	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
568206003782	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
568206003783	nudix motif; other site
568206003784	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
568206003785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206003786	Coenzyme A binding pocket [chemical binding]; other site
568206003787	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
568206003788	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
568206003789	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
568206003790	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
568206003791	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206003792	motif II; other site
568206003793	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206003794	non-specific DNA binding site [nucleotide binding]; other site
568206003795	salt bridge; other site
568206003796	sequence-specific DNA binding site [nucleotide binding]; other site
568206003797	Protein of unknown function (DUF3796); Region: DUF3796; pfam12676
568206003798	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
568206003799	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206003800	Walker A/P-loop; other site
568206003801	ATP binding site [chemical binding]; other site
568206003802	Q-loop/lid; other site
568206003803	ABC transporter signature motif; other site
568206003804	Walker B; other site
568206003805	D-loop; other site
568206003806	H-loop/switch region; other site
568206003807	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
568206003808	classical (c) SDRs; Region: SDR_c; cd05233
568206003809	NAD(P) binding site [chemical binding]; other site
568206003810	active site
568206003811	pyruvate kinase; Validated; Region: PRK06739
568206003812	active site
568206003813	domain interfaces; other site
568206003814	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
568206003815	dimer interface [polypeptide binding]; other site
568206003816	FMN binding site [chemical binding]; other site
568206003817	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206003818	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
568206003819	histidyl-tRNA synthetase; Provisional; Region: PRK12420
568206003820	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
568206003821	dimer interface [polypeptide binding]; other site
568206003822	motif 1; other site
568206003823	active site
568206003824	motif 2; other site
568206003825	motif 3; other site
568206003826	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
568206003827	anticodon binding site; other site
568206003828	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
568206003829	putative deacylase active site [active]
568206003830	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
568206003831	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206003832	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206003833	non-specific DNA binding site [nucleotide binding]; other site
568206003834	salt bridge; other site
568206003835	sequence-specific DNA binding site [nucleotide binding]; other site
568206003836	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568206003837	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
568206003838	Endonuclease I; Region: Endonuclease_1; pfam04231
568206003839	Predicted membrane protein [Function unknown]; Region: COG1288
568206003840	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
568206003841	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
568206003842	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
568206003843	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
568206003844	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
568206003845	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568206003846	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568206003847	Walker A/P-loop; other site
568206003848	ATP binding site [chemical binding]; other site
568206003849	Q-loop/lid; other site
568206003850	ABC transporter signature motif; other site
568206003851	Walker B; other site
568206003852	D-loop; other site
568206003853	H-loop/switch region; other site
568206003854	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568206003855	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
568206003856	Walker A/P-loop; other site
568206003857	ATP binding site [chemical binding]; other site
568206003858	Q-loop/lid; other site
568206003859	ABC transporter signature motif; other site
568206003860	Walker B; other site
568206003861	D-loop; other site
568206003862	H-loop/switch region; other site
568206003863	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
568206003864	YwiC-like protein; Region: YwiC; pfam14256
568206003865	SWIM zinc finger; Region: SWIM; pfam04434
568206003866	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
568206003867	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568206003868	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
568206003869	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
568206003870	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206003871	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206003872	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
568206003873	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206003874	putative DNA binding site [nucleotide binding]; other site
568206003875	putative Zn2+ binding site [ion binding]; other site
568206003876	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
568206003877	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206003878	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206003879	Walker A/P-loop; other site
568206003880	ATP binding site [chemical binding]; other site
568206003881	Q-loop/lid; other site
568206003882	ABC transporter signature motif; other site
568206003883	Walker B; other site
568206003884	D-loop; other site
568206003885	H-loop/switch region; other site
568206003886	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
568206003887	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206003888	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206003889	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206003890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206003891	putative substrate translocation pore; other site
568206003892	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206003893	MarR family; Region: MarR_2; pfam12802
568206003894	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206003895	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568206003896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206003897	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206003898	putative substrate translocation pore; other site
568206003899	NETI protein; Region: NETI; pfam14044
568206003900	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
568206003901	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
568206003902	putative metal binding site [ion binding]; other site
568206003903	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206003904	S-layer homology domain; Region: SLH; pfam00395
568206003905	S-layer homology domain; Region: SLH; pfam00395
568206003906	S-layer homology domain; Region: SLH; pfam00395
568206003907	Protein of unknown function (DUF3895); Region: DUF3895; pfam13034
568206003908	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
568206003909	A new structural DNA glycosylase; Region: AlkD_like; cd06561
568206003910	active site
568206003911	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
568206003912	amidase catalytic site [active]
568206003913	Zn binding residues [ion binding]; other site
568206003914	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206003915	S-layer homology domain; Region: SLH; pfam00395
568206003916	S-layer homology domain; Region: SLH; pfam00395
568206003917	S-layer homology domain; Region: SLH; pfam00395
568206003918	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
568206003919	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
568206003920	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
568206003921	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
568206003922	active site
568206003923	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
568206003924	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206003925	Cupin domain; Region: Cupin_2; cl17218
568206003926	Uncharacterized conserved protein [Function unknown]; Region: COG2155
568206003927	RNA polymerase sigma factor SigM; Provisional; Region: PRK09644
568206003928	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206003929	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
568206003930	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
568206003931	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
568206003932	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
568206003933	homodimer interface [polypeptide binding]; other site
568206003934	substrate-cofactor binding pocket; other site
568206003935	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206003936	catalytic residue [active]
568206003937	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
568206003938	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
568206003939	putative ligand binding site [chemical binding]; other site
568206003940	putative NAD binding site [chemical binding]; other site
568206003941	putative catalytic site [active]
568206003942	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
568206003943	L-serine binding site [chemical binding]; other site
568206003944	ACT domain interface; other site
568206003945	Uncharacterized conserved protein [Function unknown]; Region: COG4198
568206003946	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
568206003947	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
568206003948	putative transporter; Provisional; Region: PRK11021
568206003949	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
568206003950	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206003951	putative DNA binding site [nucleotide binding]; other site
568206003952	putative Zn2+ binding site [ion binding]; other site
568206003953	AsnC family; Region: AsnC_trans_reg; pfam01037
568206003954	Isochorismatase family; Region: Isochorismatase; pfam00857
568206003955	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
568206003956	catalytic triad [active]
568206003957	conserved cis-peptide bond; other site
568206003958	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
568206003959	dimerization interface [polypeptide binding]; other site
568206003960	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
568206003961	ATP binding site [chemical binding]; other site
568206003962	Acylphosphatase; Region: Acylphosphatase; pfam00708
568206003963	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
568206003964	HypF finger; Region: zf-HYPF; pfam07503
568206003965	HypF finger; Region: zf-HYPF; pfam07503
568206003966	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
568206003967	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
568206003968	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206003969	inhibitor-cofactor binding pocket; inhibition site
568206003970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206003971	catalytic residue [active]
568206003972	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
568206003973	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
568206003974	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
568206003975	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
568206003976	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
568206003977	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206003978	dimerization interface [polypeptide binding]; other site
568206003979	putative DNA binding site [nucleotide binding]; other site
568206003980	putative Zn2+ binding site [ion binding]; other site
568206003981	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206003982	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206003983	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568206003984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206003985	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
568206003986	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
568206003987	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
568206003988	FOG: PKD repeat [General function prediction only]; Region: COG3291
568206003989	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
568206003990	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
568206003991	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568206003992	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
568206003993	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206003994	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206003995	Coenzyme A binding pocket [chemical binding]; other site
568206003996	CAAX protease self-immunity; Region: Abi; pfam02517
568206003997	potential frameshift: common BLAST hit: gi|218904398|ref|YP_002452232.1| methyl-accepting chemotaxis protein
568206003998	Tar ligand binding domain homologue; Region: TarH; pfam02203
568206003999	Cache domain; Region: Cache_1; pfam02743
568206004000	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206004001	dimerization interface [polypeptide binding]; other site
568206004002	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206004003	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206004004	dimer interface [polypeptide binding]; other site
568206004005	putative CheW interface [polypeptide binding]; other site
568206004006	YolD-like protein; Region: YolD; pfam08863
568206004007	DNA polymerase IV; Reviewed; Region: PRK03103
568206004008	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
568206004009	active site
568206004010	DNA binding site [nucleotide binding]
568206004011	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
568206004012	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
568206004013	PKC phosphorylation site [posttranslational modification]; other site
568206004014	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
568206004015	TPR motif; other site
568206004016	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206004017	binding surface
568206004018	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206004019	TPR motif; other site
568206004020	binding surface
568206004021	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206004022	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206004023	DNA binding site [nucleotide binding]
568206004024	domain linker motif; other site
568206004025	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568206004026	putative dimerization interface [polypeptide binding]; other site
568206004027	putative ligand binding site [chemical binding]; other site
568206004028	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
568206004029	inhibitor-cofactor binding pocket; inhibition site
568206004030	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206004031	catalytic residue [active]
568206004032	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568206004033	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
568206004034	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206004035	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568206004036	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568206004037	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
568206004038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004039	putative substrate translocation pore; other site
568206004040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206004041	NADH(P)-binding; Region: NAD_binding_10; pfam13460
568206004042	active site
568206004043	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
568206004044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206004045	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
568206004046	putative dimer interface [polypeptide binding]; other site
568206004047	catalytic triad [active]
568206004048	F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763
568206004049	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206004050	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206004051	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206004052	dimerization interface [polypeptide binding]; other site
568206004053	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
568206004054	Cysteine-rich domain; Region: CCG; pfam02754
568206004055	Cysteine-rich domain; Region: CCG; pfam02754
568206004056	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
568206004057	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
568206004058	4Fe-4S binding domain; Region: Fer4; pfam00037
568206004059	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
568206004060	Uncharacterized conserved protein [Function unknown]; Region: COG1556
568206004061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004062	D-galactonate transporter; Region: 2A0114; TIGR00893
568206004063	putative substrate translocation pore; other site
568206004064	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206004065	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206004066	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206004067	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
568206004068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206004069	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004070	Coenzyme A binding pocket [chemical binding]; other site
568206004071	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568206004072	MarR family; Region: MarR; pfam01047
568206004073	Predicted membrane protein [Function unknown]; Region: COG2364
568206004074	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206004075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206004076	active site
568206004077	phosphorylation site [posttranslational modification]
568206004078	intermolecular recognition site; other site
568206004079	dimerization interface [polypeptide binding]; other site
568206004080	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206004081	DNA binding site [nucleotide binding]
568206004082	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
568206004083	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206004084	dimerization interface [polypeptide binding]; other site
568206004085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206004086	dimer interface [polypeptide binding]; other site
568206004087	phosphorylation site [posttranslational modification]
568206004088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206004089	ATP binding site [chemical binding]; other site
568206004090	Mg2+ binding site [ion binding]; other site
568206004091	G-X-G motif; other site
568206004092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004093	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206004094	putative substrate translocation pore; other site
568206004095	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206004096	dimerization interface [polypeptide binding]; other site
568206004097	putative DNA binding site [nucleotide binding]; other site
568206004098	Predicted transcriptional regulator [Transcription]; Region: COG2345
568206004099	putative Zn2+ binding site [ion binding]; other site
568206004100	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568206004101	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206004102	FtsX-like permease family; Region: FtsX; pfam02687
568206004103	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206004104	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206004105	Walker A/P-loop; other site
568206004106	ATP binding site [chemical binding]; other site
568206004107	Q-loop/lid; other site
568206004108	ABC transporter signature motif; other site
568206004109	Walker B; other site
568206004110	D-loop; other site
568206004111	H-loop/switch region; other site
568206004112	Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702
568206004113	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568206004114	AAA domain; Region: AAA_33; pfam13671
568206004115	AAA domain; Region: AAA_17; pfam13207
568206004116	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
568206004117	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
568206004118	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
568206004119	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
568206004120	dimer interface [polypeptide binding]; other site
568206004121	active site
568206004122	CoA binding pocket [chemical binding]; other site
568206004123	hypothetical protein; Provisional; Region: PRK06849
568206004124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206004125	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
568206004126	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568206004127	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206004128	NAD(P) binding site [chemical binding]; other site
568206004129	active site
568206004130	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
568206004131	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
568206004132	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
568206004133	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206004134	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206004135	salt bridge; other site
568206004136	non-specific DNA binding site [nucleotide binding]; other site
568206004137	sequence-specific DNA binding site [nucleotide binding]; other site
568206004138	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206004139	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206004140	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206004141	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
568206004142	active site
568206004143	metal binding site [ion binding]; metal-binding site
568206004144	Domain of unknown function (DUF4073); Region: DUF4073; pfam13285
568206004145	D-cysteine desulfhydrase; Validated; Region: PRK03910
568206004146	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
568206004147	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206004148	catalytic residue [active]
568206004149	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
568206004150	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
568206004151	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206004152	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206004153	dimerization interface [polypeptide binding]; other site
568206004154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206004155	dimer interface [polypeptide binding]; other site
568206004156	phosphorylation site [posttranslational modification]
568206004157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206004158	ATP binding site [chemical binding]; other site
568206004159	G-X-G motif; other site
568206004160	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206004161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206004162	active site
568206004163	phosphorylation site [posttranslational modification]
568206004164	intermolecular recognition site; other site
568206004165	dimerization interface [polypeptide binding]; other site
568206004166	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206004167	DNA binding site [nucleotide binding]
568206004168	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
568206004169	Malarial early transcribed membrane protein (ETRAMP); Region: ETRAMP; cl09917
568206004170	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568206004171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004172	putative substrate translocation pore; other site
568206004173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004174	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
568206004175	Cytochrome P450; Region: p450; pfam00067
568206004176	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
568206004177	Flavodoxin; Region: Flavodoxin_1; pfam00258
568206004178	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
568206004179	FAD binding pocket [chemical binding]; other site
568206004180	FAD binding motif [chemical binding]; other site
568206004181	catalytic residues [active]
568206004182	NAD binding pocket [chemical binding]; other site
568206004183	phosphate binding motif [ion binding]; other site
568206004184	beta-alpha-beta structure motif; other site
568206004185	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568206004186	MarR family; Region: MarR_2; pfam12802
568206004187	DoxX-like family; Region: DoxX_2; pfam13564
568206004188	putative monooxygenase; Provisional; Region: PRK11118
568206004189	hypothetical protein; Provisional; Region: PRK06770
568206004190	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206004191	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206004192	putative transporter; Provisional; Region: PRK11021
568206004193	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
568206004194	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206004195	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
568206004196	HEAT repeats; Region: HEAT_2; pfam13646
568206004197	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206004198	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568206004199	active site
568206004200	metal binding site [ion binding]; metal-binding site
568206004201	AAA domain; Region: AAA_11; pfam13086
568206004202	Part of AAA domain; Region: AAA_19; pfam13245
568206004203	Erp protein C-terminus; Region: Erp_C; pfam06780
568206004204	AAA domain; Region: AAA_30; pfam13604
568206004205	AAA domain; Region: AAA_12; pfam13087
568206004206	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
568206004207	putative active site [active]
568206004208	catalytic site [active]
568206004209	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
568206004210	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568206004211	metal binding site [ion binding]; metal-binding site
568206004212	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
568206004213	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206004214	putative DNA binding site [nucleotide binding]; other site
568206004215	putative Zn2+ binding site [ion binding]; other site
568206004216	AsnC family; Region: AsnC_trans_reg; pfam01037
568206004217	short chain dehydrogenase; Provisional; Region: PRK12746
568206004218	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
568206004219	NADP binding site [chemical binding]; other site
568206004220	homodimer interface [polypeptide binding]; other site
568206004221	active site
568206004222	substrate binding site [chemical binding]; other site
568206004223	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
568206004224	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
568206004225	nucleotide binding site [chemical binding]; other site
568206004226	putative NEF/HSP70 interaction site [polypeptide binding]; other site
568206004227	SBD interface [polypeptide binding]; other site
568206004228	DnaJ domain; Region: DnaJ; pfam00226
568206004229	HSP70 interaction site [polypeptide binding]; other site
568206004230	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206004231	binding surface
568206004232	TPR motif; other site
568206004233	TPR repeat; Region: TPR_11; pfam13414
568206004234	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
568206004235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206004236	dimerization interface [polypeptide binding]; other site
568206004237	putative DNA binding site [nucleotide binding]; other site
568206004238	putative Zn2+ binding site [ion binding]; other site
568206004239	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206004240	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
568206004241	putative metal binding site [ion binding]; other site
568206004242	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
568206004243	arsenical-resistance protein; Region: acr3; TIGR00832
568206004244	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
568206004245	Low molecular weight phosphatase family; Region: LMWPc; cd00115
568206004246	active site
568206004247	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
568206004248	Phosphotransferase enzyme family; Region: APH; pfam01636
568206004249	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
568206004250	active site
568206004251	ATP binding site [chemical binding]; other site
568206004252	DJ-1 family protein; Region: not_thiJ; TIGR01383
568206004253	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
568206004254	conserved cys residue [active]
568206004255	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
568206004256	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
568206004257	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
568206004258	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206004259	ABC-ATPase subunit  interface; other site
568206004260	dimer interface [polypeptide binding]; other site
568206004261	putative PBP binding regions; other site
568206004262	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
568206004263	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
568206004264	metal binding site [ion binding]; metal-binding site
568206004265	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206004266	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
568206004267	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
568206004268	UbiA prenyltransferase family; Region: UbiA; pfam01040
568206004269	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568206004270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004271	Coenzyme A binding pocket [chemical binding]; other site
568206004272	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
568206004273	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
568206004274	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
568206004275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
568206004276	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
568206004277	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
568206004278	zinc binding site [ion binding]; other site
568206004279	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
568206004280	DNA photolyase; Region: DNA_photolyase; pfam00875
568206004281	TspO/MBR family; Region: TspO_MBR; pfam03073
568206004282	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
568206004283	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
568206004284	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
568206004285	Heat induced stress protein YflT; Region: YflT; pfam11181
568206004286	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
568206004287	Mg binding site [ion binding]; other site
568206004288	nucleotide binding site [chemical binding]; other site
568206004289	putative protofilament interface [polypeptide binding]; other site
568206004290	Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821
568206004291	Cl binding site [ion binding]; other site
568206004292	oligomer interface [polypeptide binding]; other site
568206004293	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
568206004294	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206004295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206004296	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206004297	dimerization interface [polypeptide binding]; other site
568206004298	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
568206004299	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
568206004300	active site
568206004301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
568206004302	Isochorismatase family; Region: Isochorismatase; pfam00857
568206004303	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
568206004304	catalytic triad [active]
568206004305	dimer interface [polypeptide binding]; other site
568206004306	conserved cis-peptide bond; other site
568206004307	Isochorismatase family; Region: Isochorismatase; pfam00857
568206004308	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
568206004309	catalytic triad [active]
568206004310	dimer interface [polypeptide binding]; other site
568206004311	conserved cis-peptide bond; other site
568206004312	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206004313	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568206004314	TAP-like protein; Region: Abhydrolase_4; pfam08386
568206004315	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
568206004316	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
568206004317	tetramer interface [polypeptide binding]; other site
568206004318	heme binding pocket [chemical binding]; other site
568206004319	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
568206004320	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
568206004321	putative active site [active]
568206004322	putative metal binding site [ion binding]; other site
568206004323	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568206004324	Erythromycin esterase; Region: Erythro_esteras; cl17110
568206004325	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
568206004326	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
568206004327	active site
568206004328	active site
568206004329	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
568206004330	transmembrane helices; other site
568206004331	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
568206004332	amino acid carrier protein; Region: agcS; TIGR00835
568206004333	glutaminase; Reviewed; Region: PRK12357
568206004334	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
568206004335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206004336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206004337	ATP binding site [chemical binding]; other site
568206004338	Mg2+ binding site [ion binding]; other site
568206004339	G-X-G motif; other site
568206004340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206004341	Response regulator receiver domain; Region: Response_reg; pfam00072
568206004342	active site
568206004343	phosphorylation site [posttranslational modification]
568206004344	intermolecular recognition site; other site
568206004345	dimerization interface [polypeptide binding]; other site
568206004346	YcbB domain; Region: YcbB; pfam08664
568206004347	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
568206004348	Spore germination protein; Region: Spore_permease; cl17796
568206004349	Spore germination protein; Region: Spore_permease; cl17796
568206004350	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
568206004351	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
568206004352	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
568206004353	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
568206004354	Malic enzyme, N-terminal domain; Region: malic; pfam00390
568206004355	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
568206004356	putative NAD(P) binding site [chemical binding]; other site
568206004357	DoxX-like family; Region: DoxX_2; pfam13564
568206004358	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
568206004359	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
568206004360	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
568206004361	amino acid transporter; Region: 2A0306; TIGR00909
568206004362	Spore germination protein; Region: Spore_permease; cl17796
568206004363	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
568206004364	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
568206004365	GIY-YIG motif/motif A; other site
568206004366	active site
568206004367	catalytic site [active]
568206004368	putative DNA binding site [nucleotide binding]; other site
568206004369	metal binding site [ion binding]; metal-binding site
568206004370	Integrase core domain; Region: rve_3; cl15866
568206004371	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206004372	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206004373	non-specific DNA binding site [nucleotide binding]; other site
568206004374	salt bridge; other site
568206004375	sequence-specific DNA binding site [nucleotide binding]; other site
568206004376	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
568206004377	active site
568206004378	homodimer interface [polypeptide binding]; other site
568206004379	aspartate ammonia-lyase; Provisional; Region: PRK14515
568206004380	Aspartase; Region: Aspartase; cd01357
568206004381	active sites [active]
568206004382	tetramer interface [polypeptide binding]; other site
568206004383	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
568206004384	dimanganese center [ion binding]; other site
568206004385	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
568206004386	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
568206004387	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568206004388	NAD binding site [chemical binding]; other site
568206004389	catalytic Zn binding site [ion binding]; other site
568206004390	structural Zn binding site [ion binding]; other site
568206004391	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
568206004392	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
568206004393	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
568206004394	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
568206004395	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
568206004396	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
568206004397	LysE type translocator; Region: LysE; pfam01810
568206004398	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
568206004399	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
568206004400	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
568206004401	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
568206004402	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206004403	phosphoenolpyruvate synthase; Validated; Region: PRK06241
568206004404	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
568206004405	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
568206004406	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206004407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206004408	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
568206004409	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568206004410	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
568206004411	Uncharacterized conserved protein [Function unknown]; Region: COG1633
568206004412	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
568206004413	dinuclear metal binding motif [ion binding]; other site
568206004414	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004415	Coenzyme A binding pocket [chemical binding]; other site
568206004416	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
568206004417	Phosphotransferase enzyme family; Region: APH; pfam01636
568206004418	putative active site [active]
568206004419	putative substrate binding site [chemical binding]; other site
568206004420	ATP binding site [chemical binding]; other site
568206004421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
568206004422	Nucleoside recognition; Region: Gate; pfam07670
568206004423	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206004424	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206004425	Uncharacterized conserved protein [Function unknown]; Region: COG1434
568206004426	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568206004427	putative active site [active]
568206004428	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
568206004429	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
568206004430	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
568206004431	DinB superfamily; Region: DinB_2; pfam12867
568206004432	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206004433	dimerization interface [polypeptide binding]; other site
568206004434	putative DNA binding site [nucleotide binding]; other site
568206004435	putative Zn2+ binding site [ion binding]; other site
568206004436	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
568206004437	stage II sporulation protein P; Region: spore_II_P; TIGR02867
568206004438	CutC family; Region: CutC; cl01218
568206004439	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568206004440	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206004441	Catalytic site [active]
568206004442	Transcriptional regulator [Transcription]; Region: IclR; COG1414
568206004443	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
568206004444	Bacterial transcriptional regulator; Region: IclR; pfam01614
568206004445	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
568206004446	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
568206004447	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
568206004448	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
568206004449	putative active site [active]
568206004450	Protein of unknown function (DUF969); Region: DUF969; pfam06149
568206004451	Predicted membrane protein [Function unknown]; Region: COG3817
568206004452	Protein of unknown function (DUF979); Region: DUF979; pfam06166
568206004453	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
568206004454	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
568206004455	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
568206004456	putative substrate binding pocket [chemical binding]; other site
568206004457	AC domain interface; other site
568206004458	catalytic triad [active]
568206004459	AB domain interface; other site
568206004460	interchain disulfide; other site
568206004461	NAD-dependent deacetylase; Provisional; Region: PRK00481
568206004462	SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413
568206004463	NAD+ binding site [chemical binding]; other site
568206004464	substrate binding site [chemical binding]; other site
568206004465	Zn binding site [ion binding]; other site
568206004466	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568206004467	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206004468	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206004469	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568206004470	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206004471	Catalytic site [active]
568206004472	Cephalosporin hydroxylase; Region: CmcI; pfam04989
568206004473	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
568206004474	putative active site [active]
568206004475	nucleotide binding site [chemical binding]; other site
568206004476	nudix motif; other site
568206004477	putative metal binding site [ion binding]; other site
568206004478	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206004479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206004480	S-adenosylmethionine binding site [chemical binding]; other site
568206004481	Protein of unknown function (DUF2716); Region: DUF2716; pfam10898
568206004482	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
568206004483	lysine transporter; Provisional; Region: PRK10836
568206004484	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206004485	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004486	Coenzyme A binding pocket [chemical binding]; other site
568206004487	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
568206004488	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
568206004489	Phosphotransferase enzyme family; Region: APH; pfam01636
568206004490	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
568206004491	active site
568206004492	substrate binding site [chemical binding]; other site
568206004493	ATP binding site [chemical binding]; other site
568206004494	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
568206004495	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206004496	active site
568206004497	metal binding site [ion binding]; metal-binding site
568206004498	uridine kinase; Validated; Region: PRK06696
568206004499	active site
568206004500	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
568206004501	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206004502	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
568206004503	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206004504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206004505	active site
568206004506	phosphorylation site [posttranslational modification]
568206004507	intermolecular recognition site; other site
568206004508	dimerization interface [polypeptide binding]; other site
568206004509	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206004510	DNA binding site [nucleotide binding]
568206004511	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206004512	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
568206004513	phosphorylation site [posttranslational modification]
568206004514	dimer interface [polypeptide binding]; other site
568206004515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206004516	ATP binding site [chemical binding]; other site
568206004517	Mg2+ binding site [ion binding]; other site
568206004518	G-X-G motif; other site
568206004519	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
568206004520	hypothetical protein; Validated; Region: PRK00124
568206004521	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568206004522	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206004523	DNA-binding site [nucleotide binding]; DNA binding site
568206004524	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206004525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206004526	homodimer interface [polypeptide binding]; other site
568206004527	catalytic residue [active]
568206004528	EamA-like transporter family; Region: EamA; pfam00892
568206004529	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
568206004530	EamA-like transporter family; Region: EamA; pfam00892
568206004531	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
568206004532	nudix motif; other site
568206004533	Domain of unknown function (DUF3980); Region: DUF3980; pfam13140
568206004534	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206004535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004536	Coenzyme A binding pocket [chemical binding]; other site
568206004537	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568206004538	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206004539	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
568206004540	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206004541	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206004542	FtsX-like permease family; Region: FtsX; pfam02687
568206004543	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568206004544	FtsX-like permease family; Region: FtsX; pfam02687
568206004545	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206004546	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206004547	Walker A/P-loop; other site
568206004548	ATP binding site [chemical binding]; other site
568206004549	Q-loop/lid; other site
568206004550	ABC transporter signature motif; other site
568206004551	Walker B; other site
568206004552	D-loop; other site
568206004553	H-loop/switch region; other site
568206004554	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
568206004555	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
568206004556	putative NAD(P) binding site [chemical binding]; other site
568206004557	active site
568206004558	Predicted transcriptional regulators [Transcription]; Region: COG1725
568206004559	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206004560	DNA-binding site [nucleotide binding]; DNA binding site
568206004561	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206004562	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206004563	Walker A/P-loop; other site
568206004564	ATP binding site [chemical binding]; other site
568206004565	Q-loop/lid; other site
568206004566	ABC transporter signature motif; other site
568206004567	Walker B; other site
568206004568	D-loop; other site
568206004569	H-loop/switch region; other site
568206004570	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
568206004571	YfzA-like protein; Region: YfzA; pfam14118
568206004572	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
568206004573	nudix motif; other site
568206004574	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
568206004575	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
568206004576	G1 box; other site
568206004577	putative GEF interaction site [polypeptide binding]; other site
568206004578	GTP/Mg2+ binding site [chemical binding]; other site
568206004579	Switch I region; other site
568206004580	G2 box; other site
568206004581	G3 box; other site
568206004582	Switch II region; other site
568206004583	G4 box; other site
568206004584	G5 box; other site
568206004585	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
568206004586	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
568206004587	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
568206004588	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206004589	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206004590	putative DNA binding site [nucleotide binding]; other site
568206004591	putative Zn2+ binding site [ion binding]; other site
568206004592	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
568206004593	dimer interface [polypeptide binding]; other site
568206004594	FMN binding site [chemical binding]; other site
568206004595	Uncharacterized conserved protein [Function unknown]; Region: COG1359
568206004596	MoxR-like ATPases [General function prediction only]; Region: COG0714
568206004597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206004598	Walker A motif; other site
568206004599	ATP binding site [chemical binding]; other site
568206004600	Walker B motif; other site
568206004601	arginine finger; other site
568206004602	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
568206004603	Protein of unknown function DUF58; Region: DUF58; pfam01882
568206004604	potential frameshift: common BLAST hit: gi|52142485|ref|YP_084344.1| group-specific protein
568206004605	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
568206004606	Protein of unknown function (DUF3902); Region: DUF3902; pfam13042
568206004607	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206004608	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206004609	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
568206004610	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
568206004611	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
568206004612	active site
568206004613	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
568206004614	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
568206004615	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
568206004616	tetramer interface [polypeptide binding]; other site
568206004617	heme binding pocket [chemical binding]; other site
568206004618	acetylornithine aminotransferase; Provisional; Region: PRK02627
568206004619	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206004620	inhibitor-cofactor binding pocket; inhibition site
568206004621	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206004622	catalytic residue [active]
568206004623	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206004624	active site
568206004625	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
568206004626	Ligand binding site; other site
568206004627	Putative Catalytic site; other site
568206004628	DXD motif; other site
568206004629	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568206004630	active site
568206004631	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
568206004632	Ligand binding site; other site
568206004633	Putative Catalytic site; other site
568206004634	DXD motif; other site
568206004635	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206004636	active site
568206004637	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206004638	active site
568206004639	proline/glycine betaine transporter; Provisional; Region: PRK10642
568206004640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004641	putative substrate translocation pore; other site
568206004642	Domain of unknown function (DUF4018); Region: DUF4018; pfam13210
568206004643	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
568206004644	Protein of unknown function DUF58; Region: DUF58; pfam01882
568206004645	MoxR-like ATPases [General function prediction only]; Region: COG0714
568206004646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206004647	Walker A motif; other site
568206004648	ATP binding site [chemical binding]; other site
568206004649	Walker B motif; other site
568206004650	arginine finger; other site
568206004651	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206004652	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568206004653	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
568206004654	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206004655	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568206004656	active site
568206004657	metal binding site [ion binding]; metal-binding site
568206004658	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206004659	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206004661	Coenzyme A binding pocket [chemical binding]; other site
568206004662	uridine kinase; Provisional; Region: PRK07667
568206004663	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
568206004664	LytTr DNA-binding domain; Region: LytTR; pfam04397
568206004665	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
568206004666	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
568206004667	Protein of unknown function (DUF3887); Region: DUF3887; pfam13026
568206004668	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206004669	salt bridge; other site
568206004670	non-specific DNA binding site [nucleotide binding]; other site
568206004671	sequence-specific DNA binding site [nucleotide binding]; other site
568206004672	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
568206004673	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
568206004674	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
568206004675	dimer interface [polypeptide binding]; other site
568206004676	active site
568206004677	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
568206004678	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
568206004679	putative di-iron ligands [ion binding]; other site
568206004680	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
568206004681	S-methylmethionine transporter; Provisional; Region: PRK11387
568206004682	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
568206004683	Transcriptional regulator [Transcription]; Region: IclR; COG1414
568206004684	Bacterial transcriptional regulator; Region: IclR; pfam01614
568206004685	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
568206004686	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
568206004687	putative metal binding site [ion binding]; other site
568206004688	putative dimer interface [polypeptide binding]; other site
568206004689	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491
568206004690	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
568206004691	gamma-glutamyl kinase; Provisional; Region: PRK05429
568206004692	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
568206004693	nucleotide binding site [chemical binding]; other site
568206004694	homotetrameric interface [polypeptide binding]; other site
568206004695	putative phosphate binding site [ion binding]; other site
568206004696	putative allosteric binding site; other site
568206004697	PUA domain; Region: PUA; pfam01472
568206004698	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
568206004699	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
568206004700	putative catalytic cysteine [active]
568206004701	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
568206004702	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
568206004703	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
568206004704	DinB superfamily; Region: DinB_2; pfam12867
568206004705	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206004706	putative DNA binding site [nucleotide binding]; other site
568206004707	putative Zn2+ binding site [ion binding]; other site
568206004708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004709	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206004710	putative substrate translocation pore; other site
568206004711	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
568206004712	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
568206004713	active site
568206004714	NTP binding site [chemical binding]; other site
568206004715	metal binding triad [ion binding]; metal-binding site
568206004716	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206004717	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206004718	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
568206004719	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
568206004720	putative active site; other site
568206004721	catalytic residue [active]
568206004722	Cupin domain; Region: Cupin_2; pfam07883
568206004723	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568206004724	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
568206004725	putative N- and C-terminal domain interface [polypeptide binding]; other site
568206004726	putative MgATP binding site [chemical binding]; other site
568206004727	putative active site [active]
568206004728	catalytic site [active]
568206004729	metal binding site [ion binding]; metal-binding site
568206004730	putative carbohydrate binding site [chemical binding]; other site
568206004731	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568206004732	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568206004733	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
568206004734	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
568206004735	Walker A/P-loop; other site
568206004736	ATP binding site [chemical binding]; other site
568206004737	Q-loop/lid; other site
568206004738	ABC transporter signature motif; other site
568206004739	Walker B; other site
568206004740	D-loop; other site
568206004741	H-loop/switch region; other site
568206004742	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
568206004743	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
568206004744	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
568206004745	TM-ABC transporter signature motif; other site
568206004746	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
568206004747	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
568206004748	TM-ABC transporter signature motif; other site
568206004749	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
568206004750	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
568206004751	ligand binding site [chemical binding]; other site
568206004752	malate:quinone oxidoreductase; Validated; Region: PRK05257
568206004753	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
568206004754	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
568206004755	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
568206004756	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206004757	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206004758	DNA binding residues [nucleotide binding]
568206004759	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206004760	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206004761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
568206004762	hypothetical protein; Provisional; Region: PRK06762
568206004763	YfzA-like protein; Region: YfzA; pfam14118
568206004764	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206004765	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004766	Coenzyme A binding pocket [chemical binding]; other site
568206004767	Isochorismatase family; Region: Isochorismatase; pfam00857
568206004768	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
568206004769	catalytic triad [active]
568206004770	conserved cis-peptide bond; other site
568206004771	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
568206004772	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
568206004773	Domain of unknown function (DUF4020); Region: DUF4020; pfam13212
568206004774	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
568206004775	Chorismate mutase type II; Region: CM_2; cl00693
568206004776	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
568206004777	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
568206004778	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
568206004779	Tetramer interface [polypeptide binding]; other site
568206004780	active site
568206004781	FMN-binding site [chemical binding]; other site
568206004782	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
568206004783	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206004784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206004785	homodimer interface [polypeptide binding]; other site
568206004786	catalytic residue [active]
568206004787	prephenate dehydrogenase; Validated; Region: PRK06545
568206004788	prephenate dehydrogenase; Validated; Region: PRK08507
568206004789	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
568206004790	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
568206004791	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
568206004792	hinge; other site
568206004793	active site
568206004794	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
568206004795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004796	Coenzyme A binding pocket [chemical binding]; other site
568206004797	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206004798	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206004799	potential frameshift: common BLAST hit: gi|225864915|ref|YP_002750293.1| putative membrane protein, MmpL family
568206004800	MMPL family; Region: MMPL; pfam03176
568206004801	potential frameshift: common BLAST hit: gi|218904065|ref|YP_002451899.1| putative membrane protein, MmpL family
568206004802	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
568206004803	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
568206004804	hypothetical protein; Provisional; Region: PRK06761
568206004805	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
568206004806	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206004807	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206004808	ABC transporter; Region: ABC_tran_2; pfam12848
568206004809	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206004810	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
568206004811	Sulfatase; Region: Sulfatase; pfam00884
568206004812	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
568206004813	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
568206004814	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
568206004815	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
568206004816	NodB motif; other site
568206004817	active site
568206004818	catalytic site [active]
568206004819	Zn binding site [ion binding]; other site
568206004820	A new structural DNA glycosylase; Region: AlkD_like; cd06561
568206004821	active site
568206004822	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
568206004823	active site
568206004824	NTP binding site [chemical binding]; other site
568206004825	metal binding triad [ion binding]; metal-binding site
568206004826	antibiotic binding site [chemical binding]; other site
568206004827	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206004828	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206004829	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
568206004830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004831	Coenzyme A binding pocket [chemical binding]; other site
568206004832	DinB superfamily; Region: DinB_2; pfam12867
568206004833	Protein of unknown function (DUF664); Region: DUF664; pfam04978
568206004834	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
568206004835	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
568206004836	Coenzyme A binding pocket [chemical binding]; other site
568206004837	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
568206004838	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
568206004839	hypothetical protein; Provisional; Region: PRK09620
568206004840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
568206004841	binding surface
568206004842	TPR motif; other site
568206004843	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
568206004844	nudix motif; other site
568206004845	Protein of unknown function (DUF402); Region: DUF402; pfam04167
568206004846	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206004847	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206004848	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
568206004849	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
568206004850	Walker A/P-loop; other site
568206004851	ATP binding site [chemical binding]; other site
568206004852	Q-loop/lid; other site
568206004853	ABC transporter signature motif; other site
568206004854	Walker B; other site
568206004855	D-loop; other site
568206004856	H-loop/switch region; other site
568206004857	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
568206004858	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568206004859	substrate binding pocket [chemical binding]; other site
568206004860	membrane-bound complex binding site; other site
568206004861	hinge residues; other site
568206004862	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
568206004863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206004864	dimer interface [polypeptide binding]; other site
568206004865	conserved gate region; other site
568206004866	putative PBP binding loops; other site
568206004867	ABC-ATPase subunit interface; other site
568206004868	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
568206004869	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
568206004870	active site
568206004871	dimer interface [polypeptide binding]; other site
568206004872	non-prolyl cis peptide bond; other site
568206004873	insertion regions; other site
568206004874	HNH endonuclease; Region: HNH_5; pfam14279
568206004875	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568206004876	Domain of unknown function DUF20; Region: UPF0118; pfam01594
568206004877	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
568206004878	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
568206004879	Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413
568206004880	Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413
568206004881	Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413
568206004882	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206004883	DNA-binding site [nucleotide binding]; DNA binding site
568206004884	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206004885	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206004886	Walker A/P-loop; other site
568206004887	ATP binding site [chemical binding]; other site
568206004888	Q-loop/lid; other site
568206004889	ABC transporter signature motif; other site
568206004890	Walker B; other site
568206004891	D-loop; other site
568206004892	H-loop/switch region; other site
568206004893	Protein of unknown function (DUF4052); Region: DUF4052; pfam13261
568206004894	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
568206004895	CAAX protease self-immunity; Region: Abi; pfam02517
568206004896	pantothenate kinase; Provisional; Region: PRK13317
568206004897	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
568206004898	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
568206004899	aspartate aminotransferase; Provisional; Region: PRK07681
568206004900	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206004901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206004902	homodimer interface [polypeptide binding]; other site
568206004903	catalytic residue [active]
568206004904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004905	putative substrate translocation pore; other site
568206004906	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206004907	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206004908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206004909	S-adenosylmethionine binding site [chemical binding]; other site
568206004910	Protein of unknown function (DUF3970); Region: DUF3970; pfam13113
568206004911	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
568206004912	active site
568206004913	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
568206004914	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
568206004915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004916	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206004917	putative substrate translocation pore; other site
568206004918	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
568206004919	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
568206004920	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
568206004921	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
568206004922	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
568206004923	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
568206004924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004925	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206004926	putative substrate translocation pore; other site
568206004927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206004928	putative substrate translocation pore; other site
568206004929	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
568206004930	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206004931	Coenzyme A binding pocket [chemical binding]; other site
568206004932	EDD domain protein, DegV family; Region: DegV; TIGR00762
568206004933	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
568206004934	Short C-terminal domain; Region: SHOCT; pfam09851
568206004935	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
568206004936	Zn binding site [ion binding]; other site
568206004937	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
568206004938	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
568206004939	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
568206004940	Phosphotransferase enzyme family; Region: APH; pfam01636
568206004941	active site
568206004942	substrate binding site [chemical binding]; other site
568206004943	ATP binding site [chemical binding]; other site
568206004944	bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698
568206004945	bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697
568206004946	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206004947	motif II; other site
568206004948	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
568206004949	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206004950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206004951	active site
568206004952	phosphorylation site [posttranslational modification]
568206004953	intermolecular recognition site; other site
568206004954	dimerization interface [polypeptide binding]; other site
568206004955	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206004956	DNA binding site [nucleotide binding]
568206004957	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206004958	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206004959	dimerization interface [polypeptide binding]; other site
568206004960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206004961	dimer interface [polypeptide binding]; other site
568206004962	phosphorylation site [posttranslational modification]
568206004963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206004964	ATP binding site [chemical binding]; other site
568206004965	Mg2+ binding site [ion binding]; other site
568206004966	G-X-G motif; other site
568206004967	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
568206004968	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
568206004969	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206004970	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206004971	S-adenosylmethionine binding site [chemical binding]; other site
568206004972	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
568206004973	catalytic motif [active]
568206004974	Zn binding site [ion binding]; other site
568206004975	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
568206004976	Septum formation initiator; Region: DivIC; pfam04977
568206004977	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
568206004978	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
568206004979	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
568206004980	active site
568206004981	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
568206004982	NlpC/P60 family; Region: NLPC_P60; pfam00877
568206004983	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206004984	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206004985	peptide binding site [polypeptide binding]; other site
568206004986	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206004987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206004988	Coenzyme A binding pocket [chemical binding]; other site
568206004989	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
568206004990	DltD N-terminal region; Region: DltD_N; pfam04915
568206004991	DltD central region; Region: DltD_M; pfam04918
568206004992	DltD C-terminal region; Region: DltD_C; pfam04914
568206004993	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568206004994	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568206004995	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
568206004996	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
568206004997	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
568206004998	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568206004999	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
568206005000	catalytic loop [active]
568206005001	iron binding site [ion binding]; other site
568206005002	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206005003	Walker A/P-loop; other site
568206005004	PAS domain; Region: PAS; smart00091
568206005005	PAS domain; Region: PAS_9; pfam13426
568206005006	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
568206005007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206005008	Walker A motif; other site
568206005009	ATP binding site [chemical binding]; other site
568206005010	Walker B motif; other site
568206005011	arginine finger; other site
568206005012	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
568206005013	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
568206005014	hydroxyglutarate oxidase; Provisional; Region: PRK11728
568206005015	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
568206005016	Proline racemase; Region: Pro_racemase; pfam05544
568206005017	Proline racemase; Region: Pro_racemase; pfam05544
568206005018	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
568206005019	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
568206005020	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
568206005021	inhibitor site; inhibition site
568206005022	active site
568206005023	dimer interface [polypeptide binding]; other site
568206005024	catalytic residue [active]
568206005025	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
568206005026	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
568206005027	NAD(P) binding site [chemical binding]; other site
568206005028	catalytic residues [active]
568206005029	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
568206005030	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
568206005031	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
568206005032	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206005033	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005034	Coenzyme A binding pocket [chemical binding]; other site
568206005035	Chitin binding domain; Region: Chitin_bind_3; pfam03067
568206005036	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
568206005037	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
568206005038	DHHA2 domain; Region: DHHA2; pfam02833
568206005039	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
568206005040	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
568206005041	active site
568206005042	Zn binding site [ion binding]; other site
568206005043	Protein of unknown function (DUF4017); Region: DUF4017; pfam13209
568206005044	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
568206005045	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206005046	ATP binding site [chemical binding]; other site
568206005047	putative Mg++ binding site [ion binding]; other site
568206005048	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206005049	nucleotide binding region [chemical binding]; other site
568206005050	ATP-binding site [chemical binding]; other site
568206005051	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
568206005052	HRDC domain; Region: HRDC; pfam00570
568206005053	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
568206005054	putative active site pocket [active]
568206005055	dimerization interface [polypeptide binding]; other site
568206005056	putative catalytic residue [active]
568206005057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206005058	S-adenosylmethionine binding site [chemical binding]; other site
568206005059	CAAX protease self-immunity; Region: Abi; pfam02517
568206005060	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
568206005061	Part of AAA domain; Region: AAA_19; pfam13245
568206005062	Family description; Region: UvrD_C_2; pfam13538
568206005063	Protein of unknown function (DUF952); Region: DUF952; pfam06108
568206005064	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206005065	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568206005066	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
568206005067	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005068	Coenzyme A binding pocket [chemical binding]; other site
568206005069	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
568206005070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005071	Coenzyme A binding pocket [chemical binding]; other site
568206005072	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
568206005073	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
568206005074	active site
568206005075	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
568206005076	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
568206005077	S-layer homology domain; Region: SLH; pfam00395
568206005078	S-layer homology domain; Region: SLH; pfam00395
568206005079	S-layer homology domain; Region: SLH; pfam00395
568206005080	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
568206005081	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206005082	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005083	Coenzyme A binding pocket [chemical binding]; other site
568206005084	Protein of unknown function (DUF419); Region: DUF419; pfam04237
568206005085	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
568206005086	Protein of unknown function; Region: DUF3658; pfam12395
568206005087	Protein of unknown function (DUF419); Region: DUF419; cl15265
568206005088	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
568206005089	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
568206005090	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
568206005091	substrate binding site [chemical binding]; other site
568206005092	topology modulation protein; Reviewed; Region: PRK08118
568206005093	AAA domain; Region: AAA_17; pfam13207
568206005094	potential frameshift: common BLAST hit: gi|49185611|ref|YP_028863.1| chitin binding protein, putative
568206005095	Chitin binding domain; Region: Chitin_bind_3; pfam03067
568206005096	Chitin binding domain; Region: Chitin_bind_3; cl03871
568206005097	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
568206005098	Interdomain contacts; other site
568206005099	Cytokine receptor motif; other site
568206005100	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
568206005101	Interdomain contacts; other site
568206005102	Cytokine receptor motif; other site
568206005103	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
568206005104	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005105	Coenzyme A binding pocket [chemical binding]; other site
568206005106	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
568206005107	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568206005108	active site
568206005109	dimer interface [polypeptide binding]; other site
568206005110	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
568206005111	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
568206005112	catalytic loop [active]
568206005113	iron binding site [ion binding]; other site
568206005114	RNA polymerase factor sigma-70; Validated; Region: PRK06704
568206005115	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206005116	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
568206005117	DNA binding residues [nucleotide binding]
568206005118	Clp protease; Region: CLP_protease; pfam00574
568206005119	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
568206005120	oligomer interface [polypeptide binding]; other site
568206005121	active site residues [active]
568206005122	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
568206005123	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
568206005124	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
568206005125	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
568206005126	Walker A/P-loop; other site
568206005127	ATP binding site [chemical binding]; other site
568206005128	Q-loop/lid; other site
568206005129	ABC transporter signature motif; other site
568206005130	Walker B; other site
568206005131	D-loop; other site
568206005132	H-loop/switch region; other site
568206005133	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
568206005134	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206005135	dimer interface [polypeptide binding]; other site
568206005136	conserved gate region; other site
568206005137	putative PBP binding loops; other site
568206005138	ABC-ATPase subunit interface; other site
568206005139	Protein phosphatase 2C; Region: PP2C_2; pfam13672
568206005140	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
568206005141	nudix motif; other site
568206005142	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
568206005143	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
568206005144	short chain dehydrogenase; Provisional; Region: PRK06914
568206005145	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
568206005146	NADP binding site [chemical binding]; other site
568206005147	active site
568206005148	steroid binding site; other site
568206005149	DinB superfamily; Region: DinB_2; pfam12867
568206005150	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
568206005151	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
568206005152	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
568206005153	tetramer interface [polypeptide binding]; other site
568206005154	TPP-binding site [chemical binding]; other site
568206005155	heterodimer interface [polypeptide binding]; other site
568206005156	phosphorylation loop region [posttranslational modification]
568206005157	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
568206005158	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
568206005159	alpha subunit interface [polypeptide binding]; other site
568206005160	TPP binding site [chemical binding]; other site
568206005161	heterodimer interface [polypeptide binding]; other site
568206005162	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568206005163	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
568206005164	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568206005165	E3 interaction surface; other site
568206005166	lipoyl attachment site [posttranslational modification]; other site
568206005167	e3 binding domain; Region: E3_binding; pfam02817
568206005168	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
568206005169	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
568206005170	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206005171	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206005172	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568206005173	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
568206005174	Rrf2 family protein; Region: rrf2_super; TIGR00738
568206005175	Transcriptional regulator; Region: Rrf2; pfam02082
568206005176	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
568206005177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206005178	S-adenosylmethionine binding site [chemical binding]; other site
568206005179	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568206005180	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
568206005181	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568206005182	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
568206005183	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005184	Coenzyme A binding pocket [chemical binding]; other site
568206005185	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
568206005186	GAF domain; Region: GAF; pfam01590
568206005187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206005188	Walker A motif; other site
568206005189	ATP binding site [chemical binding]; other site
568206005190	Walker B motif; other site
568206005191	arginine finger; other site
568206005192	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
568206005193	Protein of unknown function (DUF3977); Region: DUF3977; pfam13122
568206005194	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
568206005195	hydrophobic ligand binding site; other site
568206005196	N-acetyltransferase; Region: Acetyltransf_2; cl00949
568206005197	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
568206005198	nudix motif; other site
568206005199	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206005200	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206005201	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568206005202	kynureninase; Region: kynureninase; TIGR01814
568206005203	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206005204	catalytic residue [active]
568206005205	arylformamidase; Region: trp_arylform; TIGR03035
568206005206	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
568206005207	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206005208	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206005209	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
568206005210	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
568206005211	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
568206005212	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
568206005213	germination protein YpeB; Region: spore_YpeB; TIGR02889
568206005214	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
568206005215	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
568206005216	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
568206005217	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206005218	Predicted membrane protein [Function unknown]; Region: COG4129
568206005219	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
568206005220	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
568206005221	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
568206005222	Mg binding site [ion binding]; other site
568206005223	nucleotide binding site [chemical binding]; other site
568206005224	putative protofilament interface [polypeptide binding]; other site
568206005225	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206005226	TAP-like protein; Region: Abhydrolase_4; pfam08386
568206005227	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568206005228	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206005229	DNA-binding site [nucleotide binding]; DNA binding site
568206005230	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206005231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206005232	homodimer interface [polypeptide binding]; other site
568206005233	catalytic residue [active]
568206005234	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
568206005235	EamA-like transporter family; Region: EamA; pfam00892
568206005236	EamA-like transporter family; Region: EamA; pfam00892
568206005237	hypothetical protein; Validated; Region: PRK06672
568206005238	DnaA N-terminal domain; Region: DnaA_N; pfam11638
568206005239	DnaA N-terminal domain; Region: DnaA_N; pfam11638
568206005240	DnaA N-terminal domain; Region: DnaA_N; pfam11638
568206005241	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
568206005242	SecY translocase; Region: SecY; pfam00344
568206005243	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
568206005244	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
568206005245	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206005246	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206005247	DNA binding residues [nucleotide binding]
568206005248	Putative zinc-finger; Region: zf-HC2; pfam13490
568206005249	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
568206005250	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
568206005251	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
568206005252	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
568206005253	active site
568206005254	Zn binding site [ion binding]; other site
568206005255	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
568206005256	carbohydrate binding site [chemical binding]; other site
568206005257	pullulanase, type I; Region: pulA_typeI; TIGR02104
568206005258	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
568206005259	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
568206005260	Ca binding site [ion binding]; other site
568206005261	active site
568206005262	catalytic site [active]
568206005263	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
568206005264	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
568206005265	putative FMN binding site [chemical binding]; other site
568206005266	NADPH bind site [chemical binding]; other site
568206005267	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
568206005268	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
568206005269	acyl-activating enzyme (AAE) consensus motif; other site
568206005270	AMP binding site [chemical binding]; other site
568206005271	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
568206005272	Condensation domain; Region: Condensation; pfam00668
568206005273	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
568206005274	Nonribosomal peptide synthase; Region: NRPS; pfam08415
568206005275	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
568206005276	acyl-activating enzyme (AAE) consensus motif; other site
568206005277	AMP binding site [chemical binding]; other site
568206005278	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
568206005279	Condensation domain; Region: Condensation; pfam00668
568206005280	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
568206005281	tyrosine decarboxylase; Region: PLN02880
568206005282	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568206005283	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206005284	catalytic residue [active]
568206005285	potential frameshift: common BLAST hit: gi|218903849|ref|YP_002451683.1| carboxylesterase
568206005286	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
568206005287	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
568206005288	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
568206005289	DinB superfamily; Region: DinB_2; pfam12867
568206005290	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
568206005291	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
568206005292	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206005293	motif II; other site
568206005294	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
568206005295	MepB protein; Region: MepB; pfam08877
568206005296	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
568206005297	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
568206005298	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
568206005299	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568206005300	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
568206005301	nudix motif; other site
568206005302	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
568206005303	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
568206005304	active site
568206005305	ATP binding site [chemical binding]; other site
568206005306	substrate binding site [chemical binding]; other site
568206005307	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
568206005308	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206005309	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005310	Coenzyme A binding pocket [chemical binding]; other site
568206005311	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
568206005312	GIY-YIG motif/motif A; other site
568206005313	active site
568206005314	catalytic site [active]
568206005315	putative DNA binding site [nucleotide binding]; other site
568206005316	metal binding site [ion binding]; metal-binding site
568206005317	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
568206005318	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
568206005319	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206005320	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206005321	metal-dependent hydrolase; Provisional; Region: PRK13291
568206005322	DinB superfamily; Region: DinB_2; pfam12867
568206005323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005324	Coenzyme A binding pocket [chemical binding]; other site
568206005325	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
568206005326	pentamer interface [polypeptide binding]; other site
568206005327	dodecaamer interface [polypeptide binding]; other site
568206005328	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
568206005329	YxiJ-like protein; Region: YxiJ; pfam14176
568206005330	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
568206005331	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
568206005332	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
568206005333	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
568206005334	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
568206005335	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
568206005336	homotrimer interaction site [polypeptide binding]; other site
568206005337	putative active site [active]
568206005338	translation initiation factor IF-2; Provisional; Region: PRK14845
568206005339	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
568206005340	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
568206005341	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206005342	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
568206005343	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
568206005344	putative active site [active]
568206005345	nucleotide binding site [chemical binding]; other site
568206005346	nudix motif; other site
568206005347	putative metal binding site [ion binding]; other site
568206005348	DNA polymerase III subunit beta; Validated; Region: PRK06673
568206005349	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
568206005350	putative DNA binding surface [nucleotide binding]; other site
568206005351	dimer interface [polypeptide binding]; other site
568206005352	beta-clamp/clamp loader binding surface; other site
568206005353	beta-clamp/translesion DNA polymerase binding surface; other site
568206005354	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
568206005355	nudix motif; other site
568206005356	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
568206005357	Cadmium resistance transporter; Region: Cad; pfam03596
568206005358	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
568206005359	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206005360	putative substrate translocation pore; other site
568206005361	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206005362	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206005363	probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601
568206005364	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
568206005365	nudix motif; other site
568206005366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005367	Coenzyme A binding pocket [chemical binding]; other site
568206005368	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
568206005369	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
568206005370	EamA-like transporter family; Region: EamA; pfam00892
568206005371	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
568206005372	EamA-like transporter family; Region: EamA; pfam00892
568206005373	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568206005374	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206005375	DNA-binding site [nucleotide binding]; DNA binding site
568206005376	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206005377	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
568206005378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206005379	homodimer interface [polypeptide binding]; other site
568206005380	catalytic residue [active]
568206005381	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
568206005382	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
568206005383	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
568206005384	active site
568206005385	metal binding site [ion binding]; metal-binding site
568206005386	catalytic site [active]
568206005387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005388	Coenzyme A binding pocket [chemical binding]; other site
568206005389	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206005390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206005391	putative substrate translocation pore; other site
568206005392	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777
568206005393	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206005394	DNA binding residues [nucleotide binding]
568206005395	putative dimer interface [polypeptide binding]; other site
568206005396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206005397	S-adenosylmethionine binding site [chemical binding]; other site
568206005398	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206005399	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206005400	Protein of unknown function (DUF975); Region: DUF975; cl10504
568206005401	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
568206005402	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
568206005403	conserved cys residue [active]
568206005404	Predicted transcriptional regulator [Transcription]; Region: COG2378
568206005405	HTH domain; Region: HTH_11; pfam08279
568206005406	WYL domain; Region: WYL; pfam13280
568206005407	Putative amidotransferase; Region: DUF4066; pfam13278
568206005408	conserved cys residue [active]
568206005409	EDD domain protein, DegV family; Region: DegV; TIGR00762
568206005410	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
568206005411	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
568206005412	putative acetyltransferase; Provisional; Region: PRK03624
568206005413	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005414	Coenzyme A binding pocket [chemical binding]; other site
568206005415	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206005416	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206005417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206005418	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206005419	putative substrate translocation pore; other site
568206005420	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568206005421	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206005422	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206005423	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
568206005424	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
568206005425	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568206005426	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
568206005427	NAD(P) binding site [chemical binding]; other site
568206005428	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
568206005429	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
568206005430	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
568206005431	active site
568206005432	ATP binding site [chemical binding]; other site
568206005433	substrate binding site [chemical binding]; other site
568206005434	activation loop (A-loop); other site
568206005435	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
568206005436	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206005437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206005438	dimer interface [polypeptide binding]; other site
568206005439	phosphorylation site [posttranslational modification]
568206005440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206005441	ATP binding site [chemical binding]; other site
568206005442	Mg2+ binding site [ion binding]; other site
568206005443	G-X-G motif; other site
568206005444	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
568206005445	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
568206005446	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568206005447	Walker A/P-loop; other site
568206005448	ATP binding site [chemical binding]; other site
568206005449	Q-loop/lid; other site
568206005450	ABC transporter signature motif; other site
568206005451	Walker B; other site
568206005452	D-loop; other site
568206005453	H-loop/switch region; other site
568206005454	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
568206005455	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568206005456	Walker A/P-loop; other site
568206005457	ATP binding site [chemical binding]; other site
568206005458	Q-loop/lid; other site
568206005459	ABC transporter signature motif; other site
568206005460	Walker B; other site
568206005461	D-loop; other site
568206005462	H-loop/switch region; other site
568206005463	hypothetical protein; Provisional; Region: PRK13661
568206005464	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
568206005465	aspartate racemase; Region: asp_race; TIGR00035
568206005466	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
568206005467	glycosyltransferase, MGT family; Region: MGT; TIGR01426
568206005468	active site
568206005469	TDP-binding site; other site
568206005470	acceptor substrate-binding pocket; other site
568206005471	homodimer interface [polypeptide binding]; other site
568206005472	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568206005473	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206005474	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206005475	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206005476	PAS domain S-box; Region: sensory_box; TIGR00229
568206005477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206005478	putative active site [active]
568206005479	heme pocket [chemical binding]; other site
568206005480	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
568206005481	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206005482	dimer interface [polypeptide binding]; other site
568206005483	phosphorylation site [posttranslational modification]
568206005484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206005485	ATP binding site [chemical binding]; other site
568206005486	Mg2+ binding site [ion binding]; other site
568206005487	G-X-G motif; other site
568206005488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206005489	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206005490	active site
568206005491	motif I; other site
568206005492	motif II; other site
568206005493	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206005494	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
568206005495	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
568206005496	Cytochrome P450; Region: p450; cl12078
568206005497	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206005498	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568206005499	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
568206005500	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
568206005501	trimer interface [polypeptide binding]; other site
568206005502	active site
568206005503	substrate binding site [chemical binding]; other site
568206005504	CoA binding site [chemical binding]; other site
568206005505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206005506	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206005507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206005508	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
568206005509	Cytochrome P450; Region: p450; cl12078
568206005510	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
568206005511	Protein of unknown function; Region: DUF3658; pfam12395
568206005512	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
568206005513	Protein of unknown function (DUF3959); Region: DUF3959; pfam13105
568206005514	Protein of unknown function (DUF3959); Region: DUF3959; pfam13105
568206005515	Protein of unknown function (DUF3962); Region: DUF3962; pfam13111
568206005516	Domain of unknown function (DUF3893); Region: DUF3893; pfam13032
568206005517	ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111
568206005518	Putative transcription activator [Transcription]; Region: TenA; COG0819
568206005519	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
568206005520	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
568206005521	ATP-grasp domain; Region: ATP-grasp_4; cl17255
568206005522	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568206005523	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206005524	DNA-binding site [nucleotide binding]; DNA binding site
568206005525	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206005526	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206005527	homodimer interface [polypeptide binding]; other site
568206005528	catalytic residue [active]
568206005529	homoserine dehydrogenase; Validated; Region: PRK06813
568206005530	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
568206005531	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
568206005532	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
568206005533	Protein of unknown function (DUF3914); Region: DUF3914; pfam13053
568206005534	hypothetical protein; Provisional; Region: PRK06760
568206005535	Predicted permease; Region: FtsX; cl11418
568206005536	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206005537	FtsX-like permease family; Region: FtsX; pfam02687
568206005538	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206005539	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206005540	Walker A/P-loop; other site
568206005541	ATP binding site [chemical binding]; other site
568206005542	Q-loop/lid; other site
568206005543	ABC transporter signature motif; other site
568206005544	Walker B; other site
568206005545	D-loop; other site
568206005546	H-loop/switch region; other site
568206005547	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
568206005548	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206005549	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206005550	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568206005551	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206005552	ABC transporter; Region: ABC_tran_2; pfam12848
568206005553	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206005554	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
568206005555	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206005556	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
568206005557	phosphorylation site [posttranslational modification]
568206005558	dimer interface [polypeptide binding]; other site
568206005559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206005560	ATP binding site [chemical binding]; other site
568206005561	Mg2+ binding site [ion binding]; other site
568206005562	G-X-G motif; other site
568206005563	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206005564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206005565	active site
568206005566	phosphorylation site [posttranslational modification]
568206005567	intermolecular recognition site; other site
568206005568	dimerization interface [polypeptide binding]; other site
568206005569	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206005570	DNA binding site [nucleotide binding]
568206005571	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
568206005572	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
568206005573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206005574	S-adenosylmethionine binding site [chemical binding]; other site
568206005575	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568206005576	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
568206005577	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568206005578	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568206005579	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568206005580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206005581	S-adenosylmethionine binding site [chemical binding]; other site
568206005582	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206005583	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568206005584	Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240
568206005585	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
568206005586	putative NAD(P) binding site [chemical binding]; other site
568206005587	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568206005588	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206005589	DNA-binding site [nucleotide binding]; DNA binding site
568206005590	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206005591	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206005592	homodimer interface [polypeptide binding]; other site
568206005593	catalytic residue [active]
568206005594	Protein of unknown function (DUF4030); Region: DUF4030; pfam13222
568206005595	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
568206005596	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
568206005597	active site
568206005598	Zn binding site [ion binding]; other site
568206005599	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
568206005600	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206005601	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
568206005602	Phosphotransferase enzyme family; Region: APH; pfam01636
568206005603	active site
568206005604	substrate binding site [chemical binding]; other site
568206005605	ATP binding site [chemical binding]; other site
568206005606	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
568206005607	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206005608	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
568206005609	nudix motif; other site
568206005610	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206005611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206005612	putative substrate translocation pore; other site
568206005613	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
568206005614	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206005615	DNA binding residues [nucleotide binding]
568206005616	drug binding residues [chemical binding]; other site
568206005617	dimer interface [polypeptide binding]; other site
568206005618	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
568206005619	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206005620	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206005621	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206005622	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568206005623	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206005624	AAA domain; Region: AAA_21; pfam13304
568206005625	Walker A/P-loop; other site
568206005626	ATP binding site [chemical binding]; other site
568206005627	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206005628	ABC transporter signature motif; other site
568206005629	Walker B; other site
568206005630	D-loop; other site
568206005631	H-loop/switch region; other site
568206005632	ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238
568206005633	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
568206005634	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
568206005635	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
568206005636	putative hydrophobic ligand binding site [chemical binding]; other site
568206005637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
568206005638	potential frameshift: common BLAST hit: gi|218903697|ref|YP_002451531.1| neutral protease
568206005639	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
568206005640	active site
568206005641	Zn binding site [ion binding]; other site
568206005642	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568206005643	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568206005644	potential frameshift: common BLAST hit: gi|49185400|ref|YP_028652.1| thermolysin metallopeptidase catalytic subunit
568206005645	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
568206005646	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005647	Coenzyme A binding pocket [chemical binding]; other site
568206005648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005649	Coenzyme A binding pocket [chemical binding]; other site
568206005650	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
568206005651	NADH(P)-binding; Region: NAD_binding_10; pfam13460
568206005652	NAD binding site [chemical binding]; other site
568206005653	substrate binding site [chemical binding]; other site
568206005654	putative active site [active]
568206005655	S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714
568206005656	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
568206005657	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206005658	Zn2+ binding site [ion binding]; other site
568206005659	Mg2+ binding site [ion binding]; other site
568206005660	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206005661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206005662	active site
568206005663	phosphorylation site [posttranslational modification]
568206005664	intermolecular recognition site; other site
568206005665	dimerization interface [polypeptide binding]; other site
568206005666	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206005667	DNA binding site [nucleotide binding]
568206005668	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206005669	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206005670	dimer interface [polypeptide binding]; other site
568206005671	phosphorylation site [posttranslational modification]
568206005672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206005673	ATP binding site [chemical binding]; other site
568206005674	Mg2+ binding site [ion binding]; other site
568206005675	G-X-G motif; other site
568206005676	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
568206005677	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206005678	DinB family; Region: DinB; cl17821
568206005679	DinB superfamily; Region: DinB_2; pfam12867
568206005680	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206005681	hypothetical protein; Provisional; Region: PRK08233
568206005682	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
568206005683	active site
568206005684	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206005685	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005686	Coenzyme A binding pocket [chemical binding]; other site
568206005687	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
568206005688	acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188
568206005689	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
568206005690	acyl-activating enzyme (AAE) consensus motif; other site
568206005691	putative AMP binding site [chemical binding]; other site
568206005692	putative active site [active]
568206005693	putative CoA binding site [chemical binding]; other site
568206005694	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
568206005695	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
568206005696	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
568206005697	enoyl-CoA hydratase; Provisional; Region: PRK07657
568206005698	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
568206005699	substrate binding site [chemical binding]; other site
568206005700	oxyanion hole (OAH) forming residues; other site
568206005701	trimer interface [polypeptide binding]; other site
568206005702	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
568206005703	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
568206005704	active site
568206005705	catalytic residues [active]
568206005706	metal binding site [ion binding]; metal-binding site
568206005707	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
568206005708	carboxyltransferase (CT) interaction site; other site
568206005709	biotinylation site [posttranslational modification]; other site
568206005710	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
568206005711	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568206005712	ATP-grasp domain; Region: ATP-grasp_4; cl17255
568206005713	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
568206005714	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
568206005715	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
568206005716	FAD binding site [chemical binding]; other site
568206005717	homotetramer interface [polypeptide binding]; other site
568206005718	substrate binding pocket [chemical binding]; other site
568206005719	catalytic base [active]
568206005720	Protein of unknown function (DUF523); Region: DUF523; pfam04463
568206005721	Uncharacterized conserved protein [Function unknown]; Region: COG3272
568206005722	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
568206005723	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206005724	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206005725	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
568206005726	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
568206005727	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568206005728	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206005729	Walker A/P-loop; other site
568206005730	ATP binding site [chemical binding]; other site
568206005731	Q-loop/lid; other site
568206005732	ABC transporter signature motif; other site
568206005733	Walker B; other site
568206005734	D-loop; other site
568206005735	H-loop/switch region; other site
568206005736	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
568206005737	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
568206005738	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568206005739	active site residue [active]
568206005740	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568206005741	active site residue [active]
568206005742	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
568206005743	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206005744	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
568206005745	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
568206005746	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206005747	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206005748	PAS fold; Region: PAS_4; pfam08448
568206005749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206005750	putative active site [active]
568206005751	heme pocket [chemical binding]; other site
568206005752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568206005753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206005754	metal binding site [ion binding]; metal-binding site
568206005755	active site
568206005756	I-site; other site
568206005757	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568206005758	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568206005759	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206005760	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206005761	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206005762	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206005763	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
568206005764	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
568206005765	S-layer homology domain; Region: SLH; pfam00395
568206005766	S-layer homology domain; Region: SLH; pfam00395
568206005767	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
568206005768	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568206005769	active site
568206005770	metal binding site [ion binding]; metal-binding site
568206005771	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
568206005772	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
568206005773	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206005774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206005775	salt bridge; other site
568206005776	non-specific DNA binding site [nucleotide binding]; other site
568206005777	sequence-specific DNA binding site [nucleotide binding]; other site
568206005778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206005779	TPR motif; other site
568206005780	binding surface
568206005781	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568206005782	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
568206005783	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206005784	active site
568206005785	metal binding site [ion binding]; metal-binding site
568206005786	DinB superfamily; Region: DinB_2; pfam12867
568206005787	DinB superfamily; Region: DinB_2; pfam12867
568206005788	KduI/IolB family; Region: KduI; pfam04962
568206005789	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
568206005790	intersubunit interface [polypeptide binding]; other site
568206005791	active site
568206005792	zinc binding site [ion binding]; other site
568206005793	Na+ binding site [ion binding]; other site
568206005794	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
568206005795	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
568206005796	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568206005797	PYR/PP interface [polypeptide binding]; other site
568206005798	dimer interface [polypeptide binding]; other site
568206005799	TPP binding site [chemical binding]; other site
568206005800	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568206005801	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
568206005802	TPP-binding site; other site
568206005803	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
568206005804	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
568206005805	tetrameric interface [polypeptide binding]; other site
568206005806	NAD binding site [chemical binding]; other site
568206005807	catalytic residues [active]
568206005808	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
568206005809	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
568206005810	substrate binding site [chemical binding]; other site
568206005811	ATP binding site [chemical binding]; other site
568206005812	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568206005813	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568206005814	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
568206005815	polyol permease family; Region: 2A0118; TIGR00897
568206005816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206005817	putative substrate translocation pore; other site
568206005818	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206005819	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206005820	DNA binding site [nucleotide binding]
568206005821	domain linker motif; other site
568206005822	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568206005823	ligand binding site [chemical binding]; other site
568206005824	dimerization interface [polypeptide binding]; other site
568206005825	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
568206005826	active site
568206005827	beta-lactamase TEM; Provisional; Region: PRK15442
568206005828	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
568206005829	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568206005830	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206005831	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206005832	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206005833	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
568206005834	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206005835	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206005836	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
568206005837	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206005838	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206005839	DNA binding residues [nucleotide binding]
568206005840	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
568206005841	active site
568206005842	catalytic triad [active]
568206005843	oxyanion hole [active]
568206005844	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
568206005845	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
568206005846	metal binding site [ion binding]; metal-binding site
568206005847	dimer interface [polypeptide binding]; other site
568206005848	Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171
568206005849	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568206005850	catalytic core [active]
568206005851	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
568206005852	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206005853	MarR family; Region: MarR_2; pfam12802
568206005854	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
568206005855	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
568206005856	dimer interface [polypeptide binding]; other site
568206005857	PYR/PP interface [polypeptide binding]; other site
568206005858	TPP binding site [chemical binding]; other site
568206005859	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568206005860	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
568206005861	TPP-binding site [chemical binding]; other site
568206005862	dimer interface [polypeptide binding]; other site
568206005863	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206005864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206005865	S-adenosylmethionine binding site [chemical binding]; other site
568206005866	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568206005867	dimer interface [polypeptide binding]; other site
568206005868	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206005869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206005870	S-adenosylmethionine binding site [chemical binding]; other site
568206005871	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206005872	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206005873	Walker A/P-loop; other site
568206005874	ATP binding site [chemical binding]; other site
568206005875	Q-loop/lid; other site
568206005876	ABC transporter signature motif; other site
568206005877	Walker B; other site
568206005878	D-loop; other site
568206005879	H-loop/switch region; other site
568206005880	FtsX-like permease family; Region: FtsX; pfam02687
568206005881	potential frameshift: common BLAST hit: gi|47527770|ref|YP_019119.1| ABC transporter permease
568206005882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206005883	putative substrate translocation pore; other site
568206005884	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206005885	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206005886	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
568206005887	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
568206005888	ATP binding site [chemical binding]; other site
568206005889	Mg++ binding site [ion binding]; other site
568206005890	motif III; other site
568206005891	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206005892	nucleotide binding region [chemical binding]; other site
568206005893	ATP-binding site [chemical binding]; other site
568206005894	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
568206005895	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
568206005896	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
568206005897	tetramer interface [polypeptide binding]; other site
568206005898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206005899	catalytic residue [active]
568206005900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
568206005901	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
568206005902	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206005903	catalytic residue [active]
568206005904	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
568206005905	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568206005906	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568206005907	nucleotide binding site [chemical binding]; other site
568206005908	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
568206005909	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568206005910	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568206005911	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568206005912	active site
568206005913	P-loop; other site
568206005914	phosphorylation site [posttranslational modification]
568206005915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
568206005916	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
568206005917	Domain of unknown function (DUF3974); Region: DUF3974; pfam13120
568206005918	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
568206005919	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206005920	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206005921	S-adenosylmethionine binding site [chemical binding]; other site
568206005922	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
568206005923	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206005924	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
568206005925	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
568206005926	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568206005927	BclB C-terminal domain; Region: exospore_TM; TIGR03721
568206005928	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
568206005929	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206005930	non-specific DNA binding site [nucleotide binding]; other site
568206005931	salt bridge; other site
568206005932	sequence-specific DNA binding site [nucleotide binding]; other site
568206005933	Cupin domain; Region: Cupin_2; pfam07883
568206005934	LysE type translocator; Region: LysE; cl00565
568206005935	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568206005936	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
568206005937	active site
568206005938	metal binding site [ion binding]; metal-binding site
568206005939	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
568206005940	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568206005941	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206005942	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
568206005943	Walker A/P-loop; other site
568206005944	ATP binding site [chemical binding]; other site
568206005945	Q-loop/lid; other site
568206005946	ABC transporter signature motif; other site
568206005947	Walker B; other site
568206005948	D-loop; other site
568206005949	H-loop/switch region; other site
568206005950	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568206005951	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206005952	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206005953	Walker A/P-loop; other site
568206005954	ATP binding site [chemical binding]; other site
568206005955	Q-loop/lid; other site
568206005956	ABC transporter signature motif; other site
568206005957	Walker B; other site
568206005958	D-loop; other site
568206005959	H-loop/switch region; other site
568206005960	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
568206005961	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206005962	Coenzyme A binding pocket [chemical binding]; other site
568206005963	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
568206005964	MOSC domain; Region: MOSC; pfam03473
568206005965	3-alpha domain; Region: 3-alpha; pfam03475
568206005966	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
568206005967	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206005968	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206005969	dimerization interface [polypeptide binding]; other site
568206005970	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
568206005971	active site
568206005972	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
568206005973	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728
568206005974	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
568206005975	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
568206005976	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206005977	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206005978	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206005979	dimerization interface [polypeptide binding]; other site
568206005980	Protein of unknown function (DUF3956); Region: DUF3956; pfam13104
568206005981	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
568206005982	hypothetical protein; Provisional; Region: PRK06770
568206005983	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206005984	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206005985	active site
568206005986	motif I; other site
568206005987	motif II; other site
568206005988	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206005989	motif II; other site
568206005990	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
568206005991	active site
568206005992	metal binding site [ion binding]; metal-binding site
568206005993	AAA domain; Region: AAA_17; pfam13207
568206005994	AAA domain; Region: AAA_18; pfam13238
568206005995	CAAX protease self-immunity; Region: Abi; pfam02517
568206005996	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568206005997	DNA-binding site [nucleotide binding]; DNA binding site
568206005998	RNA-binding motif; other site
568206005999	Cold-inducible protein YdjO; Region: YdjO; pfam14169
568206006000	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206006001	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206006002	protoporphyrinogen oxidase; Provisional; Region: PRK12416
568206006003	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568206006004	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206006005	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568206006006	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
568206006007	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
568206006008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206006009	non-specific DNA binding site [nucleotide binding]; other site
568206006010	salt bridge; other site
568206006011	sequence-specific DNA binding site [nucleotide binding]; other site
568206006012	Cupin domain; Region: Cupin_2; pfam07883
568206006013	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206006014	EamA-like transporter family; Region: EamA; pfam00892
568206006015	EamA-like transporter family; Region: EamA; pfam00892
568206006016	putative acetyltransferase YhhY; Provisional; Region: PRK10140
568206006017	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006018	Coenzyme A binding pocket [chemical binding]; other site
568206006019	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206006020	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006021	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206006022	Coenzyme A binding pocket [chemical binding]; other site
568206006023	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
568206006024	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
568206006025	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
568206006026	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006027	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568206006028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206006029	Coenzyme A binding pocket [chemical binding]; other site
568206006030	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
568206006031	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
568206006032	Protein of unknown function (DUF4021); Region: DUF4021; pfam13213
568206006033	MMPL family; Region: MMPL; pfam03176
568206006034	MMPL family; Region: MMPL; pfam03176
568206006035	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206006036	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206006037	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206006038	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
568206006039	Protein of unknown function (DUF2441); Region: DUF2441; pfam10386
568206006040	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
568206006041	active site
568206006042	dimerization interface [polypeptide binding]; other site
568206006043	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206006044	Protein of unknown function (DUF2185); Region: DUF2185; pfam09951
568206006045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206006046	S-adenosylmethionine binding site [chemical binding]; other site
568206006047	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
568206006048	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568206006049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206006050	dimer interface [polypeptide binding]; other site
568206006051	conserved gate region; other site
568206006052	ABC-ATPase subunit interface; other site
568206006053	potential frameshift: common BLAST hit: gi|225864356|ref|YP_002749734.1| ABC transporter, permease protein
568206006054	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206006055	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206006056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206006057	Protein of unknown function (DUF867); Region: DUF867; cl01713
568206006058	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206006059	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568206006060	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
568206006061	potential frameshift: common BLAST hit: gi|49185234|ref|YP_028486.1| ABC transporter, permease protein, putative
568206006062	FtsX-like permease family; Region: FtsX; pfam02687
568206006063	potential frameshift: common BLAST hit: gi|225864352|ref|YP_002749730.1| ABC transporter, ATP-binding protein
568206006064	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206006065	H-loop/switch region; other site
568206006066	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206006067	Walker A/P-loop; other site
568206006068	ATP binding site [chemical binding]; other site
568206006069	ABC transporter; Region: ABC_tran; pfam00005
568206006070	Q-loop/lid; other site
568206006071	ABC transporter signature motif; other site
568206006072	Walker B; other site
568206006073	D-loop; other site
568206006074	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
568206006075	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
568206006076	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
568206006077	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
568206006078	active site
568206006079	dimer interface [polypeptide binding]; other site
568206006080	motif 1; other site
568206006081	motif 2; other site
568206006082	motif 3; other site
568206006083	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
568206006084	anticodon binding site; other site
568206006085	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
568206006086	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206006087	RNA binding surface [nucleotide binding]; other site
568206006088	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
568206006089	probable active site [active]
568206006090	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
568206006091	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
568206006092	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
568206006093	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
568206006094	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
568206006095	active site
568206006096	catalytic triad [active]
568206006097	DinB family; Region: DinB; cl17821
568206006098	DinB superfamily; Region: DinB_2; pfam12867
568206006099	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
568206006100	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
568206006101	IHF dimer interface [polypeptide binding]; other site
568206006102	IHF - DNA interface [nucleotide binding]; other site
568206006103	Chorismate lyase; Region: Chor_lyase; cl01230
568206006104	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
568206006105	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
568206006106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206006107	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206006108	putative substrate translocation pore; other site
568206006109	MbtH-like protein; Region: MbtH; cl01279
568206006110	Condensation domain; Region: Condensation; pfam00668
568206006111	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
568206006112	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
568206006113	acyl-activating enzyme (AAE) consensus motif; other site
568206006114	AMP binding site [chemical binding]; other site
568206006115	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
568206006116	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
568206006117	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
568206006118	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
568206006119	acyl-activating enzyme (AAE) consensus motif; other site
568206006120	AMP binding site [chemical binding]; other site
568206006121	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
568206006122	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
568206006123	hydrophobic substrate binding pocket; other site
568206006124	Isochorismatase family; Region: Isochorismatase; pfam00857
568206006125	active site
568206006126	conserved cis-peptide bond; other site
568206006127	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
568206006128	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
568206006129	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
568206006130	acyl-activating enzyme (AAE) consensus motif; other site
568206006131	active site
568206006132	AMP binding site [chemical binding]; other site
568206006133	substrate binding site [chemical binding]; other site
568206006134	isochorismate synthase DhbC; Validated; Region: PRK06923
568206006135	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
568206006136	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
568206006137	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
568206006138	putative NAD(P) binding site [chemical binding]; other site
568206006139	active site
568206006140	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
568206006141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206006142	putative substrate translocation pore; other site
568206006143	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206006144	dimerization interface [polypeptide binding]; other site
568206006145	putative DNA binding site [nucleotide binding]; other site
568206006146	putative Zn2+ binding site [ion binding]; other site
568206006147	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
568206006148	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
568206006149	Walker A/P-loop; other site
568206006150	ATP binding site [chemical binding]; other site
568206006151	Q-loop/lid; other site
568206006152	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
568206006153	ABC transporter signature motif; other site
568206006154	Walker B; other site
568206006155	D-loop; other site
568206006156	H-loop/switch region; other site
568206006157	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
568206006158	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
568206006159	active site
568206006160	metal binding site [ion binding]; metal-binding site
568206006161	DNA binding site [nucleotide binding]
568206006162	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
568206006163	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
568206006164	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
568206006165	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
568206006166	substrate binding site [chemical binding]; other site
568206006167	oxyanion hole (OAH) forming residues; other site
568206006168	trimer interface [polypeptide binding]; other site
568206006169	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
568206006170	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
568206006171	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
568206006172	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
568206006173	tetrameric interface [polypeptide binding]; other site
568206006174	NAD binding site [chemical binding]; other site
568206006175	catalytic residues [active]
568206006176	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
568206006177	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
568206006178	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
568206006179	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
568206006180	active site
568206006181	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
568206006182	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
568206006183	tetramer interface [polypeptide binding]; other site
568206006184	active site
568206006185	Mg2+/Mn2+ binding site [ion binding]; other site
568206006186	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
568206006187	2-methylcitrate dehydratase; Region: prpD; TIGR02330
568206006188	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
568206006189	dimer interface [polypeptide binding]; other site
568206006190	Citrate synthase; Region: Citrate_synt; pfam00285
568206006191	active site
568206006192	coenzyme A binding site [chemical binding]; other site
568206006193	citrylCoA binding site [chemical binding]; other site
568206006194	oxalacetate/citrate binding site [chemical binding]; other site
568206006195	catalytic triad [active]
568206006196	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
568206006197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206006198	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206006199	putative substrate translocation pore; other site
568206006200	Transglycosylase; Region: Transgly; pfam00912
568206006201	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568206006202	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206006203	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
568206006204	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
568206006205	YolD-like protein; Region: YolD; pfam08863
568206006206	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
568206006207	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
568206006208	C1q domain; Region: C1q; cl17543
568206006209	CHRD domain; Region: CHRD; pfam07452
568206006210	Protein of unknown function (DUF3956); Region: DUF3956; pfam13104
568206006211	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
568206006212	homotrimer interaction site [polypeptide binding]; other site
568206006213	putative active site [active]
568206006214	Replication-relaxation; Region: Replic_Relax; pfam13814
568206006215	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568206006216	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206006217	non-specific DNA binding site [nucleotide binding]; other site
568206006218	salt bridge; other site
568206006219	sequence-specific DNA binding site [nucleotide binding]; other site
568206006220	Restriction endonuclease; Region: Mrr_cat; pfam04471
568206006221	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
568206006222	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
568206006223	putative active site [active]
568206006224	putative active site [active]
568206006225	catalytic site [active]
568206006226	catalytic site [active]
568206006227	S-layer homology domain; Region: SLH; pfam00395
568206006228	S-layer homology domain; Region: SLH; pfam00395
568206006229	S-layer homology domain; Region: SLH; pfam00395
568206006230	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
568206006231	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
568206006232	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
568206006233	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
568206006234	DNA binding site [nucleotide binding]
568206006235	active site
568206006236	Int/Topo IB signature motif; other site
568206006237	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568206006238	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568206006239	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
568206006240	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
568206006241	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
568206006242	active site
568206006243	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
568206006244	SpoOM protein; Region: Spo0M; pfam07070
568206006245	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
568206006246	Catalytic domain of Protein Kinases; Region: PKc; cd00180
568206006247	active site
568206006248	ATP binding site [chemical binding]; other site
568206006249	substrate binding site [chemical binding]; other site
568206006250	activation loop (A-loop); other site
568206006251	YozD-like protein; Region: YozD; pfam14162
568206006252	Protein of unknown function (DUF3930); Region: DUF3930; pfam13067
568206006253	hypothetical protein; Provisional; Region: PRK13672
568206006254	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
568206006255	toxin interface [polypeptide binding]; other site
568206006256	Zn binding site [ion binding]; other site
568206006257	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
568206006258	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206006259	FeS/SAM binding site; other site
568206006260	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
568206006261	PAS fold; Region: PAS_4; pfam08448
568206006262	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
568206006263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206006264	Walker A motif; other site
568206006265	ATP binding site [chemical binding]; other site
568206006266	Walker B motif; other site
568206006267	arginine finger; other site
568206006268	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
568206006269	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
568206006270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206006271	acetylornithine deacetylase; Validated; Region: PRK06915
568206006272	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
568206006273	metal binding site [ion binding]; metal-binding site
568206006274	dimer interface [polypeptide binding]; other site
568206006275	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
568206006276	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
568206006277	hypothetical protein; Provisional; Region: PRK06917
568206006278	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206006279	inhibitor-cofactor binding pocket; inhibition site
568206006280	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206006281	catalytic residue [active]
568206006282	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
568206006283	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
568206006284	Histidine kinase N terminal; Region: HisK_N; pfam09385
568206006285	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206006286	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206006287	dimer interface [polypeptide binding]; other site
568206006288	phosphorylation site [posttranslational modification]
568206006289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206006290	ATP binding site [chemical binding]; other site
568206006291	Mg2+ binding site [ion binding]; other site
568206006292	G-X-G motif; other site
568206006293	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
568206006294	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
568206006295	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
568206006296	NAD(P) binding site [chemical binding]; other site
568206006297	catalytic residues [active]
568206006298	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568206006299	Domain of unknown function DUF21; Region: DUF21; pfam01595
568206006300	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568206006301	Transporter associated domain; Region: CorC_HlyC; smart01091
568206006302	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
568206006303	Helix-turn-helix domain; Region: HTH_17; cl17695
568206006304	Protein of unknown function (DUF524); Region: DUF524; pfam04411
568206006305	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
568206006306	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
568206006307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206006308	dimer interface [polypeptide binding]; other site
568206006309	conserved gate region; other site
568206006310	ABC-ATPase subunit interface; other site
568206006311	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
568206006312	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
568206006313	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
568206006314	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
568206006315	Walker A/P-loop; other site
568206006316	ATP binding site [chemical binding]; other site
568206006317	Q-loop/lid; other site
568206006318	ABC transporter signature motif; other site
568206006319	Walker B; other site
568206006320	D-loop; other site
568206006321	H-loop/switch region; other site
568206006322	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568206006323	Uncharacterized conserved protein [Function unknown]; Region: COG1434
568206006324	putative active site [active]
568206006325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206006326	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206006327	putative substrate translocation pore; other site
568206006328	Predicted flavoprotein [General function prediction only]; Region: COG0431
568206006329	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568206006330	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568206006331	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206006332	active site
568206006333	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568206006334	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568206006335	Erythromycin esterase; Region: Erythro_esteras; cl17110
568206006336	Erythromycin esterase; Region: Erythro_esteras; pfam05139
568206006337	potential frameshift: common BLAST hit: gi|225864249|ref|YP_002749627.1| alkaline D-peptidase
568206006338	Beta-lactamase; Region: Beta-lactamase; cl17358
568206006339	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206006340	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206006341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
568206006342	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206006343	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568206006344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206006345	dimer interface [polypeptide binding]; other site
568206006346	conserved gate region; other site
568206006347	ABC-ATPase subunit interface; other site
568206006348	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
568206006349	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
568206006350	NAD binding site [chemical binding]; other site
568206006351	substrate binding site [chemical binding]; other site
568206006352	catalytic Zn binding site [ion binding]; other site
568206006353	tetramer interface [polypeptide binding]; other site
568206006354	structural Zn binding site [ion binding]; other site
568206006355	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568206006356	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568206006357	putative active site [active]
568206006358	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
568206006359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568206006360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206006361	active site
568206006362	phosphorylation site [posttranslational modification]
568206006363	intermolecular recognition site; other site
568206006364	dimerization interface [polypeptide binding]; other site
568206006365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
568206006366	DNA binding residues [nucleotide binding]
568206006367	dimerization interface [polypeptide binding]; other site
568206006368	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
568206006369	GAF domain; Region: GAF; pfam01590
568206006370	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
568206006371	Histidine kinase; Region: HisKA_3; pfam07730
568206006372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206006373	ATP binding site [chemical binding]; other site
568206006374	Mg2+ binding site [ion binding]; other site
568206006375	G-X-G motif; other site
568206006376	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
568206006377	Mechanosensitive ion channel; Region: MS_channel; pfam00924
568206006378	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
568206006379	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
568206006380	putative dimer interface [polypeptide binding]; other site
568206006381	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
568206006382	nudix motif; other site
568206006383	Isochorismatase family; Region: Isochorismatase; pfam00857
568206006384	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
568206006385	catalytic triad [active]
568206006386	conserved cis-peptide bond; other site
568206006387	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
568206006388	FMN binding site [chemical binding]; other site
568206006389	dimer interface [polypeptide binding]; other site
568206006390	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
568206006391	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
568206006392	homodimer interface [polypeptide binding]; other site
568206006393	substrate-cofactor binding pocket; other site
568206006394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206006395	catalytic residue [active]
568206006396	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
568206006397	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
568206006398	siderophore binding site; other site
568206006399	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206006400	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
568206006401	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
568206006402	active site
568206006403	dimer interface [polypeptide binding]; other site
568206006404	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
568206006405	Ligand Binding Site [chemical binding]; other site
568206006406	Molecular Tunnel; other site
568206006407	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
568206006408	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
568206006409	putative dimer interface [polypeptide binding]; other site
568206006410	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
568206006411	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
568206006412	Cu(I) binding site [ion binding]; other site
568206006413	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
568206006414	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
568206006415	EDD domain protein, DegV family; Region: DegV; TIGR00762
568206006416	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
568206006417	Protein of unknown function (DUF2535); Region: DUF2535; pfam10751
568206006418	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
568206006419	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
568206006420	Haemolysin-III related; Region: HlyIII; cl03831
568206006421	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
568206006422	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
568206006423	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
568206006424	putative acyl-acceptor binding pocket; other site
568206006425	azoreductase; Reviewed; Region: PRK00170
568206006426	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568206006427	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
568206006428	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206006429	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
568206006430	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206006431	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
568206006432	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
568206006433	folate binding site [chemical binding]; other site
568206006434	NADP+ binding site [chemical binding]; other site
568206006435	thymidylate synthase; Region: thym_sym; TIGR03284
568206006436	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
568206006437	dimerization interface [polypeptide binding]; other site
568206006438	active site
568206006439	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206006440	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206006441	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
568206006442	Peptidase family S41; Region: Peptidase_S41; pfam03572
568206006443	Active site serine [active]
568206006444	Phosphotransferase enzyme family; Region: APH; pfam01636
568206006445	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
568206006446	active site
568206006447	ATP binding site [chemical binding]; other site
568206006448	substrate binding site [chemical binding]; other site
568206006449	hypothetical protein; Provisional; Region: PRK06724
568206006450	active site
568206006451	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
568206006452	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206006453	motif II; other site
568206006454	YpjP-like protein; Region: YpjP; pfam14005
568206006455	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
568206006456	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568206006457	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206006458	Walker A/P-loop; other site
568206006459	ATP binding site [chemical binding]; other site
568206006460	Q-loop/lid; other site
568206006461	ABC transporter signature motif; other site
568206006462	Walker B; other site
568206006463	D-loop; other site
568206006464	H-loop/switch region; other site
568206006465	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568206006466	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006467	Coenzyme A binding pocket [chemical binding]; other site
568206006468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206006469	active site
568206006470	motif I; other site
568206006471	motif II; other site
568206006472	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
568206006473	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206006474	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006475	Coenzyme A binding pocket [chemical binding]; other site
568206006476	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
568206006477	homodimer interaction site [polypeptide binding]; other site
568206006478	cofactor binding site; other site
568206006479	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
568206006480	aspartate racemase; Region: asp_race; TIGR00035
568206006481	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
568206006482	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
568206006483	active site
568206006484	NAD binding site [chemical binding]; other site
568206006485	metal binding site [ion binding]; metal-binding site
568206006486	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
568206006487	fructuronate transporter; Provisional; Region: PRK10034; cl15264
568206006488	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
568206006489	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206006490	motif II; other site
568206006491	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
568206006492	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
568206006493	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206006494	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
568206006495	Na2 binding site [ion binding]; other site
568206006496	putative substrate binding site 1 [chemical binding]; other site
568206006497	Na binding site 1 [ion binding]; other site
568206006498	putative substrate binding site 2 [chemical binding]; other site
568206006499	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568206006500	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568206006501	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568206006502	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206006503	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206006504	dimerization interface [polypeptide binding]; other site
568206006505	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206006506	dimer interface [polypeptide binding]; other site
568206006507	phosphorylation site [posttranslational modification]
568206006508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206006509	ATP binding site [chemical binding]; other site
568206006510	Mg2+ binding site [ion binding]; other site
568206006511	G-X-G motif; other site
568206006512	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206006513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206006514	active site
568206006515	phosphorylation site [posttranslational modification]
568206006516	intermolecular recognition site; other site
568206006517	dimerization interface [polypeptide binding]; other site
568206006518	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206006519	DNA binding site [nucleotide binding]
568206006520	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
568206006521	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
568206006522	transmembrane helices; other site
568206006523	glycerate kinase; Region: TIGR00045
568206006524	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
568206006525	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
568206006526	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
568206006527	Transposase; Region: DEDD_Tnp_IS110; pfam01548
568206006528	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
568206006529	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
568206006530	catalytic residues [active]
568206006531	catalytic nucleophile [active]
568206006532	Recombinase; Region: Recombinase; pfam07508
568206006533	Immunity protein Imm3; Region: Imm3; pfam14425
568206006534	Proteins of 100 residues with WXG; Region: WXG100; cl02005
568206006535	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
568206006536	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
568206006537	SseB protein; Region: SseB; cl06279
568206006538	potential frameshift: common BLAST hit: gi|225864174|ref|YP_002749552.1| group-specific protein
568206006539	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206006540	binding surface
568206006541	TPR motif; other site
568206006542	TPR repeat; Region: TPR_11; pfam13414
568206006543	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206006544	binding surface
568206006545	TPR motif; other site
568206006546	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206006547	binding surface
568206006548	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206006549	TPR motif; other site
568206006550	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
568206006551	active site
568206006552	ATP binding site [chemical binding]; other site
568206006553	substrate binding site [chemical binding]; other site
568206006554	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
568206006555	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
568206006556	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568206006557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206006558	Walker A motif; other site
568206006559	ATP binding site [chemical binding]; other site
568206006560	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568206006561	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
568206006562	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
568206006563	metal ion-dependent adhesion site (MIDAS); other site
568206006564	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
568206006565	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
568206006566	Dimer interface [polypeptide binding]; other site
568206006567	anticodon binding site; other site
568206006568	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
568206006569	homodimer interface [polypeptide binding]; other site
568206006570	motif 1; other site
568206006571	motif 2; other site
568206006572	active site
568206006573	motif 3; other site
568206006574	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568206006575	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
568206006576	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568206006577	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
568206006578	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
568206006579	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568206006580	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
568206006581	Zn binding site [ion binding]; other site
568206006582	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
568206006583	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
568206006584	HIGH motif; other site
568206006585	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
568206006586	active site
568206006587	KMSKS motif; other site
568206006588	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
568206006589	tRNA binding surface [nucleotide binding]; other site
568206006590	anticodon binding site; other site
568206006591	TPR repeat; Region: TPR_11; pfam13414
568206006592	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206006593	binding surface
568206006594	TPR motif; other site
568206006595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206006596	binding surface
568206006597	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206006598	TPR motif; other site
568206006599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206006600	Tetratricopeptide repeat; Region: TPR_16; pfam13432
568206006601	binding surface
568206006602	TPR motif; other site
568206006603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206006604	binding surface
568206006605	TPR motif; other site
568206006606	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
568206006607	putative active site [active]
568206006608	TPR repeat; Region: TPR_11; pfam13414
568206006609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206006610	TPR motif; other site
568206006611	binding surface
568206006612	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206006613	Methyltransferase domain; Region: Methyltransf_12; pfam08242
568206006614	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
568206006615	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
568206006616	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
568206006617	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
568206006618	active site
568206006619	HIGH motif; other site
568206006620	KMSK motif region; other site
568206006621	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
568206006622	tRNA binding surface [nucleotide binding]; other site
568206006623	anticodon binding site; other site
568206006624	Brix domain; Region: Brix; cl00935
568206006625	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
568206006626	Disulphide isomerase; Region: Disulph_isomer; pfam06491
568206006627	Protein of unknown function, DUF393; Region: DUF393; pfam04134
568206006628	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
568206006629	Virulence factor; Region: Virulence_fact; pfam13769
568206006630	HEAT repeats; Region: HEAT_2; pfam13646
568206006631	HEAT repeats; Region: HEAT_2; pfam13646
568206006632	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
568206006633	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
568206006634	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
568206006635	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206006636	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206006637	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
568206006638	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
568206006639	dimer interface [polypeptide binding]; other site
568206006640	ssDNA binding site [nucleotide binding]; other site
568206006641	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568206006642	Domain of unknown function (DUF4318); Region: DUF4318; pfam14201
568206006643	Bax inhibitor 1 like; Region: BaxI_1; cl17691
568206006644	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568206006645	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206006646	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206006647	ABC transporter; Region: ABC_tran_2; pfam12848
568206006648	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206006649	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
568206006650	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206006651	Zn2+ binding site [ion binding]; other site
568206006652	Mg2+ binding site [ion binding]; other site
568206006653	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
568206006654	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
568206006655	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
568206006656	PGAP1-like protein; Region: PGAP1; pfam07819
568206006657	N-acetyltransferase; Region: Acetyltransf_2; cl00949
568206006658	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
568206006659	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
568206006660	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
568206006661	Hemerythrin-like domain; Region: Hr-like; cd12108
568206006662	Fe binding site [ion binding]; other site
568206006663	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
568206006664	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206006665	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206006666	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
568206006667	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
568206006668	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
568206006669	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
568206006670	[2Fe-2S] cluster binding site [ion binding]; other site
568206006671	bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168
568206006672	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
568206006673	active site
568206006674	SAM binding site [chemical binding]; other site
568206006675	homodimer interface [polypeptide binding]; other site
568206006676	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
568206006677	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
568206006678	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
568206006679	putative active site [active]
568206006680	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
568206006681	putative active site [active]
568206006682	precorrin-2 dehydrogenase; Validated; Region: PRK06719
568206006683	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
568206006684	Predicted permeases [General function prediction only]; Region: COG0679
568206006685	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
568206006686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206006687	putative substrate translocation pore; other site
568206006688	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
568206006689	MoaE interaction surface [polypeptide binding]; other site
568206006690	MoeB interaction surface [polypeptide binding]; other site
568206006691	thiocarboxylated glycine; other site
568206006692	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
568206006693	MoaE homodimer interface [polypeptide binding]; other site
568206006694	MoaD interaction [polypeptide binding]; other site
568206006695	active site residues [active]
568206006696	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
568206006697	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
568206006698	dimer interface [polypeptide binding]; other site
568206006699	putative functional site; other site
568206006700	putative MPT binding site; other site
568206006701	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
568206006702	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
568206006703	ATP binding site [chemical binding]; other site
568206006704	substrate interface [chemical binding]; other site
568206006705	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
568206006706	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206006707	FeS/SAM binding site; other site
568206006708	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
568206006709	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568206006710	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568206006711	ligand binding site [chemical binding]; other site
568206006712	flexible hinge region; other site
568206006713	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
568206006714	putative switch regulator; other site
568206006715	non-specific DNA interactions [nucleotide binding]; other site
568206006716	DNA binding site [nucleotide binding]
568206006717	sequence specific DNA binding site [nucleotide binding]; other site
568206006718	putative cAMP binding site [chemical binding]; other site
568206006719	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
568206006720	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206006721	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206006722	Walker A/P-loop; other site
568206006723	ATP binding site [chemical binding]; other site
568206006724	Q-loop/lid; other site
568206006725	ABC transporter signature motif; other site
568206006726	Walker B; other site
568206006727	D-loop; other site
568206006728	H-loop/switch region; other site
568206006729	Predicted transcriptional regulators [Transcription]; Region: COG1725
568206006730	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206006731	DNA-binding site [nucleotide binding]; DNA binding site
568206006732	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
568206006733	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
568206006734	nitrate reductase, beta subunit; Region: narH; TIGR01660
568206006735	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
568206006736	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
568206006737	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
568206006738	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
568206006739	[4Fe-4S] binding site [ion binding]; other site
568206006740	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
568206006741	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
568206006742	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
568206006743	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
568206006744	molybdopterin cofactor binding site; other site
568206006745	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
568206006746	MoxR-like ATPases [General function prediction only]; Region: COG0714
568206006747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206006748	Walker A motif; other site
568206006749	ATP binding site [chemical binding]; other site
568206006750	Walker B motif; other site
568206006751	arginine finger; other site
568206006752	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
568206006753	Protein of unknown function DUF58; Region: DUF58; pfam01882
568206006754	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
568206006755	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
568206006756	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
568206006757	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
568206006758	catalytic residues [active]
568206006759	dimer interface [polypeptide binding]; other site
568206006760	Protein of unknown function (DUF3925); Region: DUF3925; pfam13063
568206006761	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206006762	Domain of unknown function (DUF3600); Region: DUF3600; pfam12207
568206006763	RNA polymerase sigma factor; Provisional; Region: PRK12543
568206006764	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206006765	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206006766	DNA binding residues [nucleotide binding]
568206006767	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568206006768	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
568206006769	NADP binding site [chemical binding]; other site
568206006770	dimer interface [polypeptide binding]; other site
568206006771	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206006772	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
568206006773	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
568206006774	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
568206006775	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568206006776	ATP binding site [chemical binding]; other site
568206006777	putative Mg++ binding site [ion binding]; other site
568206006778	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206006779	nucleotide binding region [chemical binding]; other site
568206006780	ATP-binding site [chemical binding]; other site
568206006781	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
568206006782	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
568206006783	Potassium binding sites [ion binding]; other site
568206006784	Cesium cation binding sites [ion binding]; other site
568206006785	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206006786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206006787	S-adenosylmethionine binding site [chemical binding]; other site
568206006788	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
568206006789	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
568206006790	Cupin domain; Region: Cupin_2; cl17218
568206006791	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206006792	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006793	Coenzyme A binding pocket [chemical binding]; other site
568206006794	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206006795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006796	Coenzyme A binding pocket [chemical binding]; other site
568206006797	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206006798	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
568206006799	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
568206006800	Src Homology 3 domain superfamily; Region: SH3; cl17036
568206006801	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206006802	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
568206006803	active site
568206006804	metal binding site [ion binding]; metal-binding site
568206006805	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006806	Coenzyme A binding pocket [chemical binding]; other site
568206006807	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568206006808	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206006809	DNA-binding site [nucleotide binding]; DNA binding site
568206006810	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206006811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206006812	homodimer interface [polypeptide binding]; other site
568206006813	catalytic residue [active]
568206006814	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206006815	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206006816	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206006817	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
568206006818	glycosyltransferase, MGT family; Region: MGT; TIGR01426
568206006819	active site
568206006820	TDP-binding site; other site
568206006821	acceptor substrate-binding pocket; other site
568206006822	homodimer interface [polypeptide binding]; other site
568206006823	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
568206006824	active site
568206006825	ATP binding site [chemical binding]; other site
568206006826	substrate binding site [chemical binding]; other site
568206006827	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006828	Coenzyme A binding pocket [chemical binding]; other site
568206006829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006830	Coenzyme A binding pocket [chemical binding]; other site
568206006831	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206006832	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206006833	S-adenosylmethionine binding site [chemical binding]; other site
568206006834	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
568206006835	alanine racemase; Reviewed; Region: alr; PRK00053
568206006836	active site
568206006837	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568206006838	dimer interface [polypeptide binding]; other site
568206006839	substrate binding site [chemical binding]; other site
568206006840	catalytic residues [active]
568206006841	DinB superfamily; Region: DinB_2; pfam12867
568206006842	DinB family; Region: DinB; cl17821
568206006843	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206006844	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206006845	active site
568206006846	motif I; other site
568206006847	motif II; other site
568206006848	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206006849	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568206006850	catalytic core [active]
568206006851	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
568206006852	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
568206006853	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
568206006854	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206006855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206006856	putative substrate translocation pore; other site
568206006857	amidase; Provisional; Region: PRK06828
568206006858	Amidase; Region: Amidase; pfam01425
568206006859	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663
568206006860	nudix motif; other site
568206006861	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
568206006862	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
568206006863	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206006864	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006865	Coenzyme A binding pocket [chemical binding]; other site
568206006866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206006867	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
568206006868	stage II sporulation protein P; Region: spore_II_P; TIGR02867
568206006869	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
568206006870	DinB superfamily; Region: DinB_2; pfam12867
568206006871	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
568206006872	dimer interface [polypeptide binding]; other site
568206006873	putative tRNA-binding site [nucleotide binding]; other site
568206006874	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
568206006875	FOG: CBS domain [General function prediction only]; Region: COG0517
568206006876	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
568206006877	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568206006878	Domain of unknown function DUF21; Region: DUF21; pfam01595
568206006879	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568206006880	Transporter associated domain; Region: CorC_HlyC; smart01091
568206006881	Protein of unknown function (DUF456); Region: DUF456; pfam04306
568206006882	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
568206006883	NADH(P)-binding; Region: NAD_binding_10; pfam13460
568206006884	NAD binding site [chemical binding]; other site
568206006885	substrate binding site [chemical binding]; other site
568206006886	putative active site [active]
568206006887	potential frameshift: common BLAST hit: gi|225864023|ref|YP_002749401.1| putative spore coat protein F
568206006888	Coat F domain; Region: Coat_F; pfam07875
568206006889	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
568206006890	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568206006891	putative active site [active]
568206006892	catalytic site [active]
568206006893	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568206006894	putative active site [active]
568206006895	catalytic site [active]
568206006896	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
568206006897	Predicted membrane protein [Function unknown]; Region: COG3689
568206006898	Predicted permeases [General function prediction only]; Region: COG0701
568206006899	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
568206006900	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
568206006901	Cl binding site [ion binding]; other site
568206006902	oligomer interface [polypeptide binding]; other site
568206006903	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
568206006904	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568206006905	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568206006906	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568206006907	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
568206006908	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
568206006909	nudix motif; other site
568206006910	CotH protein; Region: CotH; pfam08757
568206006911	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568206006912	catalytic core [active]
568206006913	short chain dehydrogenase; Provisional; Region: PRK08309
568206006914	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
568206006915	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206006916	active site
568206006917	metal binding site [ion binding]; metal-binding site
568206006918	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206006919	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206006920	peptide binding site [polypeptide binding]; other site
568206006921	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
568206006922	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
568206006923	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
568206006924	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568206006925	DNA binding site [nucleotide binding]
568206006926	active site
568206006927	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
568206006928	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
568206006929	active site
568206006930	FMN binding site [chemical binding]; other site
568206006931	substrate binding site [chemical binding]; other site
568206006932	homotetramer interface [polypeptide binding]; other site
568206006933	catalytic residue [active]
568206006934	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
568206006935	NADH(P)-binding; Region: NAD_binding_10; pfam13460
568206006936	NAD binding site [chemical binding]; other site
568206006937	active site
568206006938	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
568206006939	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
568206006940	metal binding site [ion binding]; metal-binding site
568206006941	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
568206006942	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959
568206006943	Replication-relaxation; Region: Replic_Relax; pfam13814
568206006944	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206006945	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206006946	Coenzyme A binding pocket [chemical binding]; other site
568206006947	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
568206006948	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
568206006949	P-loop, Walker A motif; other site
568206006950	Base recognition motif; other site
568206006951	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
568206006952	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206006953	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206006954	active site
568206006955	catalytic tetrad [active]
568206006956	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206006957	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206006958	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
568206006959	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568206006960	Protein of unknown function (DUF3896); Region: DUF3896; pfam13035
568206006961	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
568206006962	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
568206006963	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
568206006964	Protein of unknown function (DUF3939); Region: DUF3939; pfam13075
568206006965	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
568206006966	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
568206006967	dimerization interface [polypeptide binding]; other site
568206006968	DPS ferroxidase diiron center [ion binding]; other site
568206006969	ion pore; other site
568206006970	Uncharacterized membrane protein [Function unknown]; Region: COG3949
568206006971	Protein of unknown function (DUF3979); Region: DUF3979; pfam13141
568206006972	Tar ligand binding domain homologue; Region: TarH; pfam02203
568206006973	Cache domain; Region: Cache_1; pfam02743
568206006974	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
568206006975	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206006976	dimerization interface [polypeptide binding]; other site
568206006977	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206006978	dimer interface [polypeptide binding]; other site
568206006979	putative CheW interface [polypeptide binding]; other site
568206006980	GTPase RsgA; Reviewed; Region: PRK01889
568206006981	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
568206006982	RNA binding site [nucleotide binding]; other site
568206006983	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
568206006984	GTPase/Zn-binding domain interface [polypeptide binding]; other site
568206006985	GTP/Mg2+ binding site [chemical binding]; other site
568206006986	G4 box; other site
568206006987	G5 box; other site
568206006988	G1 box; other site
568206006989	Switch I region; other site
568206006990	G2 box; other site
568206006991	G3 box; other site
568206006992	Switch II region; other site
568206006993	Protein of unknown function (DUF664); Region: DUF664; pfam04978
568206006994	DinB superfamily; Region: DinB_2; pfam12867
568206006995	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
568206006996	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568206006997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206006998	putative substrate translocation pore; other site
568206006999	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206007000	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206007001	active site
568206007002	catalytic tetrad [active]
568206007003	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206007004	dimerization interface [polypeptide binding]; other site
568206007005	putative DNA binding site [nucleotide binding]; other site
568206007006	putative Zn2+ binding site [ion binding]; other site
568206007007	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
568206007008	active site
568206007009	catalytic residues [active]
568206007010	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
568206007011	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
568206007012	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206007013	FtsX-like permease family; Region: FtsX; pfam02687
568206007014	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
568206007015	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
568206007016	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
568206007017	homodimer interface [polypeptide binding]; other site
568206007018	NAD binding pocket [chemical binding]; other site
568206007019	ATP binding pocket [chemical binding]; other site
568206007020	Mg binding site [ion binding]; other site
568206007021	active-site loop [active]
568206007022	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
568206007023	nudix motif; other site
568206007024	Domain of unknown function (DUF4083); Region: DUF4083; pfam13314
568206007025	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
568206007026	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
568206007027	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
568206007028	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
568206007029	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
568206007030	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
568206007031	active site
568206007032	nucleophile elbow; other site
568206007033	Protein of unknown function (DUF3933); Region: DUF3933; pfam13069
568206007034	Lysine efflux permease [General function prediction only]; Region: COG1279
568206007035	potential frameshift: common BLAST hit: gi|218903139|ref|YP_002450973.1| putative multidrug resistance protein
568206007036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206007037	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206007038	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
568206007039	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
568206007040	acyl carrier protein; Provisional; Region: PRK07639
568206007041	potential frameshift: common BLAST hit: gi|49184852|ref|YP_028104.1| acyl-CoA synthetase
568206007042	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206007043	AMP binding site [chemical binding]; other site
568206007044	active site
568206007045	CoA binding site [chemical binding]; other site
568206007046	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206007047	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206007048	acyl-activating enzyme (AAE) consensus motif; other site
568206007049	acyl-activating enzyme (AAE) consensus motif; other site
568206007050	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
568206007051	IucA / IucC family; Region: IucA_IucC; pfam04183
568206007052	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
568206007053	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
568206007054	IucA / IucC family; Region: IucA_IucC; pfam04183
568206007055	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
568206007056	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206007057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206007058	Coenzyme A binding pocket [chemical binding]; other site
568206007059	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
568206007060	MgtC family; Region: MgtC; pfam02308
568206007061	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
568206007062	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568206007063	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
568206007064	NodB motif; other site
568206007065	active site
568206007066	catalytic site [active]
568206007067	Zn binding site [ion binding]; other site
568206007068	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206007069	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206007070	dimerization interface [polypeptide binding]; other site
568206007071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206007072	dimer interface [polypeptide binding]; other site
568206007073	phosphorylation site [posttranslational modification]
568206007074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206007075	ATP binding site [chemical binding]; other site
568206007076	Mg2+ binding site [ion binding]; other site
568206007077	G-X-G motif; other site
568206007078	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206007079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206007080	active site
568206007081	phosphorylation site [posttranslational modification]
568206007082	intermolecular recognition site; other site
568206007083	dimerization interface [polypeptide binding]; other site
568206007084	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206007085	DNA binding site [nucleotide binding]
568206007086	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
568206007087	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
568206007088	homoserine kinase; Provisional; Region: PRK01212
568206007089	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
568206007090	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
568206007091	threonine synthase; Reviewed; Region: PRK06721
568206007092	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
568206007093	homodimer interface [polypeptide binding]; other site
568206007094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206007095	catalytic residue [active]
568206007096	homoserine dehydrogenase; Provisional; Region: PRK06349
568206007097	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
568206007098	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
568206007099	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
568206007100	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
568206007101	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
568206007102	nudix motif; other site
568206007103	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568206007104	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
568206007105	NodB motif; other site
568206007106	active site
568206007107	catalytic site [active]
568206007108	metal binding site [ion binding]; metal-binding site
568206007109	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
568206007110	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
568206007111	classical (c) SDRs; Region: SDR_c; cd05233
568206007112	NAD(P) binding site [chemical binding]; other site
568206007113	active site
568206007114	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
568206007115	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206007116	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206007117	dimerization interface [polypeptide binding]; other site
568206007118	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206007119	dimer interface [polypeptide binding]; other site
568206007120	phosphorylation site [posttranslational modification]
568206007121	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206007122	ATP binding site [chemical binding]; other site
568206007123	Mg2+ binding site [ion binding]; other site
568206007124	G-X-G motif; other site
568206007125	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206007126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206007127	active site
568206007128	phosphorylation site [posttranslational modification]
568206007129	intermolecular recognition site; other site
568206007130	dimerization interface [polypeptide binding]; other site
568206007131	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206007132	DNA binding site [nucleotide binding]
568206007133	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206007134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206007135	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568206007136	Walker A/P-loop; other site
568206007137	ATP binding site [chemical binding]; other site
568206007138	Q-loop/lid; other site
568206007139	ABC transporter signature motif; other site
568206007140	Walker B; other site
568206007141	D-loop; other site
568206007142	H-loop/switch region; other site
568206007143	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568206007144	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206007145	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206007146	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206007147	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206007148	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206007149	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
568206007150	NlpC/P60 family; Region: NLPC_P60; pfam00877
568206007151	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
568206007152	dimer interface [polypeptide binding]; other site
568206007153	FMN binding site [chemical binding]; other site
568206007154	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206007155	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
568206007156	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
568206007157	putative dimer interface [polypeptide binding]; other site
568206007158	catalytic triad [active]
568206007159	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
568206007160	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206007161	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
568206007162	Walker A/P-loop; other site
568206007163	ATP binding site [chemical binding]; other site
568206007164	Q-loop/lid; other site
568206007165	ABC transporter signature motif; other site
568206007166	Walker B; other site
568206007167	D-loop; other site
568206007168	H-loop/switch region; other site
568206007169	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
568206007170	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206007171	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
568206007172	Walker A/P-loop; other site
568206007173	ATP binding site [chemical binding]; other site
568206007174	Q-loop/lid; other site
568206007175	ABC transporter signature motif; other site
568206007176	Walker B; other site
568206007177	D-loop; other site
568206007178	H-loop/switch region; other site
568206007179	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
568206007180	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
568206007181	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
568206007182	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
568206007183	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
568206007184	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
568206007185	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
568206007186	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206007187	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206007188	putative Zn2+ binding site [ion binding]; other site
568206007189	putative DNA binding site [nucleotide binding]; other site
568206007190	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
568206007191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206007192	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
568206007193	LysR substrate binding domain; Region: LysR_substrate; pfam03466
568206007194	dimerization interface [polypeptide binding]; other site
568206007195	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
568206007196	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
568206007197	TM-ABC transporter signature motif; other site
568206007198	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
568206007199	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
568206007200	TM-ABC transporter signature motif; other site
568206007201	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
568206007202	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
568206007203	Walker A/P-loop; other site
568206007204	ATP binding site [chemical binding]; other site
568206007205	Q-loop/lid; other site
568206007206	ABC transporter signature motif; other site
568206007207	Walker B; other site
568206007208	D-loop; other site
568206007209	H-loop/switch region; other site
568206007210	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
568206007211	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
568206007212	Walker A/P-loop; other site
568206007213	ATP binding site [chemical binding]; other site
568206007214	Q-loop/lid; other site
568206007215	ABC transporter signature motif; other site
568206007216	Walker B; other site
568206007217	D-loop; other site
568206007218	H-loop/switch region; other site
568206007219	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
568206007220	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
568206007221	putative ligand binding site [chemical binding]; other site
568206007222	hypothetical protein; Validated; Region: PRK06840
568206007223	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
568206007224	active site
568206007225	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
568206007226	dimer interaction site [polypeptide binding]; other site
568206007227	substrate-binding tunnel; other site
568206007228	active site
568206007229	catalytic site [active]
568206007230	substrate binding site [chemical binding]; other site
568206007231	acyl-CoA synthetase; Validated; Region: PRK06839
568206007232	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206007233	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
568206007234	acyl-activating enzyme (AAE) consensus motif; other site
568206007235	putative AMP binding site [chemical binding]; other site
568206007236	putative active site [active]
568206007237	putative CoA binding site [chemical binding]; other site
568206007238	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206007239	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206007240	S-layer homology domain; Region: SLH; pfam00395
568206007241	S-layer homology domain; Region: SLH; pfam00395
568206007242	S-layer homology domain; Region: SLH; pfam00395
568206007243	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
568206007244	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
568206007245	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
568206007246	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
568206007247	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568206007248	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
568206007249	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568206007250	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568206007251	NAD binding site [chemical binding]; other site
568206007252	dimer interface [polypeptide binding]; other site
568206007253	substrate binding site [chemical binding]; other site
568206007254	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568206007255	amidase; Provisional; Region: PRK06707
568206007256	Amidase; Region: Amidase; cl11426
568206007257	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
568206007258	dimer interface [polypeptide binding]; other site
568206007259	FMN binding site [chemical binding]; other site
568206007260	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
568206007261	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
568206007262	catalytic residues [active]
568206007263	Predicted transcriptional regulator [Transcription]; Region: COG1959
568206007264	Transcriptional regulator; Region: Rrf2; pfam02082
568206007265	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206007266	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206007267	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206007268	dimerization interface [polypeptide binding]; other site
568206007269	EamA-like transporter family; Region: EamA; pfam00892
568206007270	EamA-like transporter family; Region: EamA; pfam00892
568206007271	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206007272	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
568206007273	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
568206007274	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
568206007275	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
568206007276	YtkA-like; Region: YtkA; pfam13115
568206007277	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206007278	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
568206007279	dimer interface [polypeptide binding]; other site
568206007280	substrate binding site [chemical binding]; other site
568206007281	metal binding site [ion binding]; metal-binding site
568206007282	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
568206007283	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
568206007284	azoreductase; Provisional; Region: PRK13555
568206007285	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
568206007286	Sodium Bile acid symporter family; Region: SBF; cl17470
568206007287	DNA topoisomerase III; Provisional; Region: PRK07726
568206007288	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
568206007289	active site
568206007290	putative interdomain interaction site [polypeptide binding]; other site
568206007291	putative metal-binding site [ion binding]; other site
568206007292	putative nucleotide binding site [chemical binding]; other site
568206007293	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
568206007294	domain I; other site
568206007295	DNA binding groove [nucleotide binding]
568206007296	phosphate binding site [ion binding]; other site
568206007297	domain II; other site
568206007298	domain III; other site
568206007299	nucleotide binding site [chemical binding]; other site
568206007300	catalytic site [active]
568206007301	domain IV; other site
568206007302	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
568206007303	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
568206007304	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206007305	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206007306	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206007307	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206007308	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206007309	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206007310	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206007311	potential frameshift: common BLAST hit: gi|49184776|ref|YP_028028.1| multicopper oxidase family protein
568206007312	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
568206007313	Multicopper oxidase; Region: Cu-oxidase; pfam00394
568206007314	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
568206007315	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
568206007316	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
568206007317	proline aminopeptidase P II; Provisional; Region: PRK10879
568206007318	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
568206007319	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
568206007320	active site
568206007321	VPS10 domain; Region: VPS10; smart00602
568206007322	Family description; Region: DsbD_2; pfam13386
568206007323	hypothetical protein; Provisional; Region: PRK01631
568206007324	Protein of unknown function (DUF1453); Region: DUF1453; cl02009
568206007325	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
568206007326	active site
568206007327	catalytic motif [active]
568206007328	Zn binding site [ion binding]; other site
568206007329	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
568206007330	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
568206007331	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
568206007332	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
568206007333	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
568206007334	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
568206007335	Nucleoside recognition; Region: Gate; pfam07670
568206007336	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
568206007337	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
568206007338	intersubunit interface [polypeptide binding]; other site
568206007339	active site
568206007340	catalytic residue [active]
568206007341	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568206007342	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206007343	DNA binding residues [nucleotide binding]
568206007344	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568206007345	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
568206007346	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
568206007347	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
568206007348	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
568206007349	potential frameshift: common BLAST hit: gi|222095539|ref|YP_002529599.1| YdaO
568206007350	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
568206007351	ydaO/yuaA leader
568206007352	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
568206007353	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
568206007354	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
568206007355	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
568206007356	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
568206007357	active site residue [active]
568206007358	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
568206007359	manganese transport protein MntH; Reviewed; Region: PRK00701
568206007360	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
568206007361	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206007362	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206007363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206007364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206007365	dimer interface [polypeptide binding]; other site
568206007366	phosphorylation site [posttranslational modification]
568206007367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206007368	ATP binding site [chemical binding]; other site
568206007369	Mg2+ binding site [ion binding]; other site
568206007370	G-X-G motif; other site
568206007371	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206007372	dimerization interface [polypeptide binding]; other site
568206007373	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206007374	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206007375	active site
568206007376	phosphorylation site [posttranslational modification]
568206007377	intermolecular recognition site; other site
568206007378	dimerization interface [polypeptide binding]; other site
568206007379	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206007380	DNA binding site [nucleotide binding]
568206007381	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206007382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206007383	Coenzyme A binding pocket [chemical binding]; other site
568206007384	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
568206007385	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206007386	FeS/SAM binding site; other site
568206007387	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
568206007388	hypothetical protein; Provisional; Region: PRK06922
568206007389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206007390	S-adenosylmethionine binding site [chemical binding]; other site
568206007391	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
568206007392	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206007393	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206007394	peptide binding site [polypeptide binding]; other site
568206007395	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206007396	5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493
568206007397	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
568206007398	active site
568206007399	putative substrate binding pocket [chemical binding]; other site
568206007400	potential frameshift: common BLAST hit: gi|49184740|ref|YP_027992.1| acetyltransferase
568206007401	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206007402	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206007403	Coenzyme A binding pocket [chemical binding]; other site
568206007404	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
568206007405	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
568206007406	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
568206007407	LytTr DNA-binding domain; Region: LytTR; pfam04397
568206007408	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
568206007409	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
568206007410	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568206007411	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
568206007412	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
568206007413	putative active site [active]
568206007414	metal binding site [ion binding]; metal-binding site
568206007415	drug efflux system protein MdtG; Provisional; Region: PRK09874
568206007416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206007417	putative substrate translocation pore; other site
568206007418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206007419	Coenzyme A binding pocket [chemical binding]; other site
568206007420	Protein of unknown function (DUF554); Region: DUF554; pfam04474
568206007421	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
568206007422	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
568206007423	putative active site [active]
568206007424	putative metal binding site [ion binding]; other site
568206007425	threonine dehydratase; Validated; Region: PRK08639
568206007426	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
568206007427	tetramer interface [polypeptide binding]; other site
568206007428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206007429	catalytic residue [active]
568206007430	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
568206007431	putative Ile/Val binding site [chemical binding]; other site
568206007432	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
568206007433	ketol-acid reductoisomerase; Provisional; Region: PRK05479
568206007434	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
568206007435	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
568206007436	acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737
568206007437	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725
568206007438	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568206007439	PYR/PP interface [polypeptide binding]; other site
568206007440	dimer interface [polypeptide binding]; other site
568206007441	TPP binding site [chemical binding]; other site
568206007442	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568206007443	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
568206007444	TPP-binding site [chemical binding]; other site
568206007445	dimer interface [polypeptide binding]; other site
568206007446	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
568206007447	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
568206007448	homodimer interface [polypeptide binding]; other site
568206007449	substrate-cofactor binding pocket; other site
568206007450	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206007451	catalytic residue [active]
568206007452	short chain dehydrogenase; Provisional; Region: PRK12747
568206007453	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
568206007454	NADP binding site [chemical binding]; other site
568206007455	homodimer interface [polypeptide binding]; other site
568206007456	active site
568206007457	substrate binding site [chemical binding]; other site
568206007458	methionine sulfoxide reductase A; Provisional; Region: PRK14054
568206007459	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
568206007460	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
568206007461	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
568206007462	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
568206007463	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
568206007464	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
568206007465	Predicted membrane protein [Function unknown]; Region: COG2323
568206007466	Mor transcription activator family; Region: Mor; cl02360
568206007467	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568206007468	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
568206007469	NodB motif; other site
568206007470	putative active site [active]
568206007471	putative catalytic site [active]
568206007472	putative Zn binding site [ion binding]; other site
568206007473	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
568206007474	Na2 binding site [ion binding]; other site
568206007475	putative substrate binding site 1 [chemical binding]; other site
568206007476	Na binding site 1 [ion binding]; other site
568206007477	putative substrate binding site 2 [chemical binding]; other site
568206007478	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
568206007479	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568206007480	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
568206007481	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206007482	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206007483	Coenzyme A binding pocket [chemical binding]; other site
568206007484	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
568206007485	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
568206007486	dimer interface [polypeptide binding]; other site
568206007487	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206007488	catalytic residue [active]
568206007489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206007490	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206007491	putative substrate translocation pore; other site
568206007492	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206007493	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206007494	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
568206007495	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
568206007496	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
568206007497	HflX GTPase family; Region: HflX; cd01878
568206007498	G1 box; other site
568206007499	GTP/Mg2+ binding site [chemical binding]; other site
568206007500	Switch I region; other site
568206007501	G2 box; other site
568206007502	G3 box; other site
568206007503	Switch II region; other site
568206007504	G4 box; other site
568206007505	G5 box; other site
568206007506	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
568206007507	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
568206007508	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
568206007509	dimer interface [polypeptide binding]; other site
568206007510	active site
568206007511	CoA binding pocket [chemical binding]; other site
568206007512	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206007513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
568206007514	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
568206007515	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
568206007516	Carbon starvation protein CstA; Region: CstA; pfam02554
568206007517	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
568206007518	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206007519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206007520	putative substrate translocation pore; other site
568206007521	S-layer homology domain; Region: SLH; pfam00395
568206007522	S-layer homology domain; Region: SLH; pfam00395
568206007523	S-layer homology domain; Region: SLH; pfam00395
568206007524	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
568206007525	S-layer homology domain; Region: SLH; pfam00395
568206007526	S-layer homology domain; Region: SLH; pfam00395
568206007527	S-layer homology domain; Region: SLH; pfam00395
568206007528	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
568206007529	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568206007530	active site
568206007531	metal binding site [ion binding]; metal-binding site
568206007532	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
568206007533	putative active site [active]
568206007534	nucleotide binding site [chemical binding]; other site
568206007535	nudix motif; other site
568206007536	putative metal binding site [ion binding]; other site
568206007537	YndJ-like protein; Region: YndJ; pfam14158
568206007538	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
568206007539	DoxX-like family; Region: DoxX_3; pfam13781
568206007540	aspartate kinase; Reviewed; Region: PRK06635
568206007541	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
568206007542	putative nucleotide binding site [chemical binding]; other site
568206007543	putative catalytic residues [active]
568206007544	putative Mg ion binding site [ion binding]; other site
568206007545	putative aspartate binding site [chemical binding]; other site
568206007546	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
568206007547	putative allosteric regulatory site; other site
568206007548	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
568206007549	putative allosteric regulatory residue; other site
568206007550	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
568206007551	putative dimer interface [polypeptide binding]; other site
568206007552	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206007553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206007554	non-specific DNA binding site [nucleotide binding]; other site
568206007555	salt bridge; other site
568206007556	sequence-specific DNA binding site [nucleotide binding]; other site
568206007557	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
568206007558	dimer interface [polypeptide binding]; other site
568206007559	active site
568206007560	SWIM zinc finger; Region: SWIM; pfam04434
568206007561	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
568206007562	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
568206007563	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206007564	ATP binding site [chemical binding]; other site
568206007565	putative Mg++ binding site [ion binding]; other site
568206007566	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206007567	nucleotide binding region [chemical binding]; other site
568206007568	ATP-binding site [chemical binding]; other site
568206007569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206007570	Response regulator receiver domain; Region: Response_reg; pfam00072
568206007571	active site
568206007572	phosphorylation site [posttranslational modification]
568206007573	intermolecular recognition site; other site
568206007574	dimerization interface [polypeptide binding]; other site
568206007575	YcbB domain; Region: YcbB; pfam08664
568206007576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206007577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206007578	ATP binding site [chemical binding]; other site
568206007579	Mg2+ binding site [ion binding]; other site
568206007580	G-X-G motif; other site
568206007581	malate dehydrogenase; Provisional; Region: PRK13529
568206007582	Malic enzyme, N-terminal domain; Region: malic; pfam00390
568206007583	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
568206007584	NAD(P) binding site [chemical binding]; other site
568206007585	aspartate ammonia-lyase; Provisional; Region: PRK14515
568206007586	Aspartase; Region: Aspartase; cd01357
568206007587	active sites [active]
568206007588	tetramer interface [polypeptide binding]; other site
568206007589	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
568206007590	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
568206007591	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
568206007592	putative nucleotide binding site [chemical binding]; other site
568206007593	uridine monophosphate binding site [chemical binding]; other site
568206007594	homohexameric interface [polypeptide binding]; other site
568206007595	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568206007596	PLD-like domain; Region: PLDc_2; pfam13091
568206007597	putative active site [active]
568206007598	catalytic site [active]
568206007599	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568206007600	PLD-like domain; Region: PLDc_2; pfam13091
568206007601	putative active site [active]
568206007602	catalytic site [active]
568206007603	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
568206007604	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
568206007605	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
568206007606	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
568206007607	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206007608	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206007609	Walker A/P-loop; other site
568206007610	ATP binding site [chemical binding]; other site
568206007611	Q-loop/lid; other site
568206007612	ABC transporter signature motif; other site
568206007613	Walker B; other site
568206007614	D-loop; other site
568206007615	H-loop/switch region; other site
568206007616	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
568206007617	Histidine kinase; Region: HisKA_3; pfam07730
568206007618	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568206007619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206007620	active site
568206007621	phosphorylation site [posttranslational modification]
568206007622	intermolecular recognition site; other site
568206007623	dimerization interface [polypeptide binding]; other site
568206007624	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
568206007625	DNA binding residues [nucleotide binding]
568206007626	dimerization interface [polypeptide binding]; other site
568206007627	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
568206007628	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206007629	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206007630	DNA binding residues [nucleotide binding]
568206007631	Protein of unknown function (DUF445); Region: DUF445; pfam04286
568206007632	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
568206007633	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
568206007634	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206007635	catalytic residue [active]
568206007636	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
568206007637	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
568206007638	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
568206007639	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206007640	non-specific DNA binding site [nucleotide binding]; other site
568206007641	salt bridge; other site
568206007642	sequence-specific DNA binding site [nucleotide binding]; other site
568206007643	Cupin domain; Region: Cupin_2; pfam07883
568206007644	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
568206007645	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
568206007646	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
568206007647	catalytic residues [active]
568206007648	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
568206007649	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
568206007650	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
568206007651	Penicillinase repressor; Region: Pencillinase_R; pfam03965
568206007652	Protein of unknown function (DUF3942); Region: DUF3942; pfam13078
568206007653	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
568206007654	active site pocket [active]
568206007655	oxyanion hole [active]
568206007656	catalytic triad [active]
568206007657	active site nucleophile [active]
568206007658	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568206007659	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
568206007660	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568206007661	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
568206007662	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
568206007663	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
568206007664	fumarate hydratase; Reviewed; Region: fumC; PRK00485
568206007665	Class II fumarases; Region: Fumarase_classII; cd01362
568206007666	active site
568206007667	tetramer interface [polypeptide binding]; other site
568206007668	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
568206007669	Methyltransferase domain; Region: Methyltransf_24; pfam13578
568206007670	TIGR03943 family protein; Region: TIGR03943
568206007671	Predicted permeases [General function prediction only]; Region: COG0701
568206007672	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
568206007673	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
568206007674	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
568206007675	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206007676	EamA-like transporter family; Region: EamA; pfam00892
568206007677	EamA-like transporter family; Region: EamA; pfam00892
568206007678	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206007679	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
568206007680	DNA-binding site [nucleotide binding]; DNA binding site
568206007681	FCD domain; Region: FCD; pfam07729
568206007682	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
568206007683	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
568206007684	VPS10 domain; Region: VPS10; smart00602
568206007685	VPS10 domain; Region: VPS10; smart00602
568206007686	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
568206007687	RNA polymerase factor sigma-70; Validated; Region: PRK06811
568206007688	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206007689	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206007690	DNA binding residues [nucleotide binding]
568206007691	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
568206007692	active site
568206007693	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
568206007694	dimer interface [polypeptide binding]; other site
568206007695	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
568206007696	Ligand Binding Site [chemical binding]; other site
568206007697	Molecular Tunnel; other site
568206007698	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
568206007699	MarR family; Region: MarR_2; cl17246
568206007700	hypothetical protein; Provisional; Region: PRK09272
568206007701	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
568206007702	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568206007703	catalytic core [active]
568206007704	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
568206007705	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
568206007706	Cupin; Region: Cupin_1; smart00835
568206007707	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
568206007708	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
568206007709	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
568206007710	Beta-Casp domain; Region: Beta-Casp; smart01027
568206007711	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
568206007712	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
568206007713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206007714	dimer interface [polypeptide binding]; other site
568206007715	conserved gate region; other site
568206007716	putative PBP binding loops; other site
568206007717	ABC-ATPase subunit interface; other site
568206007718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206007719	dimer interface [polypeptide binding]; other site
568206007720	conserved gate region; other site
568206007721	putative PBP binding loops; other site
568206007722	ABC-ATPase subunit interface; other site
568206007723	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
568206007724	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
568206007725	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
568206007726	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206007727	Walker A/P-loop; other site
568206007728	ATP binding site [chemical binding]; other site
568206007729	Q-loop/lid; other site
568206007730	ABC transporter signature motif; other site
568206007731	Walker B; other site
568206007732	D-loop; other site
568206007733	H-loop/switch region; other site
568206007734	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206007735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206007736	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206007737	dimerization interface [polypeptide binding]; other site
568206007738	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
568206007739	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206007740	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206007741	putative substrate translocation pore; other site
568206007742	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206007743	non-specific DNA binding site [nucleotide binding]; other site
568206007744	salt bridge; other site
568206007745	sequence-specific DNA binding site [nucleotide binding]; other site
568206007746	small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861
568206007747	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
568206007748	Dienelactone hydrolase family; Region: DLH; pfam01738
568206007749	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206007750	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206007751	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
568206007752	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
568206007753	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
568206007754	Predicted transcriptional regulators [Transcription]; Region: COG1378
568206007755	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
568206007756	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
568206007757	C-terminal domain interface [polypeptide binding]; other site
568206007758	sugar binding site [chemical binding]; other site
568206007759	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
568206007760	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
568206007761	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
568206007762	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
568206007763	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889
568206007764	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
568206007765	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
568206007766	FHIPEP family; Region: FHIPEP; pfam00771
568206007767	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
568206007768	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
568206007769	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
568206007770	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
568206007771	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
568206007772	flagellar motor switch protein; Validated; Region: PRK06788
568206007773	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
568206007774	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
568206007775	flagellar motor switch protein; Validated; Region: PRK06789
568206007776	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
568206007777	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
568206007778	N-acetyl-D-glucosamine binding site [chemical binding]; other site
568206007779	catalytic residue [active]
568206007780	flagellin; Provisional; Region: PRK12807
568206007781	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
568206007782	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
568206007783	putative transposase OrfB; Reviewed; Region: PHA02517
568206007784	Tetratricopeptide repeat; Region: TPR_16; pfam13432
568206007785	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
568206007786	putative metal binding site; other site
568206007787	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568206007788	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206007789	TPR repeat; Region: TPR_11; pfam13414
568206007790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206007791	binding surface
568206007792	TPR motif; other site
568206007793	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568206007794	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206007795	active site
568206007796	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
568206007797	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
568206007798	putative CheA interaction surface; other site
568206007799	Response regulator receiver domain; Region: Response_reg; pfam00072
568206007800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206007801	active site
568206007802	phosphorylation site [posttranslational modification]
568206007803	intermolecular recognition site; other site
568206007804	dimerization interface [polypeptide binding]; other site
568206007805	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
568206007806	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
568206007807	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
568206007808	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
568206007809	flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792
568206007810	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
568206007811	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
568206007812	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
568206007813	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568206007814	Walker A motif; other site
568206007815	ATP binding site [chemical binding]; other site
568206007816	Walker B motif; other site
568206007817	flagellar assembly protein H; Validated; Region: fliH; PRK06800
568206007818	Flagellar assembly protein FliH; Region: FliH; pfam02108
568206007819	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
568206007820	FliG C-terminal domain; Region: FliG_C; pfam01706
568206007821	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
568206007822	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
568206007823	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
568206007824	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
568206007825	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
568206007826	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
568206007827	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
568206007828	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
568206007829	Flagellar protein FliS; Region: FliS; cl00654
568206007830	flagellar capping protein; Validated; Region: fliD; PRK06798
568206007831	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
568206007832	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
568206007833	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
568206007834	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
568206007835	potential frameshift: common BLAST hit: gi|49184566|ref|YP_027818.1| flagellar hook-associated protein FlgK
568206007836	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
568206007837	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
568206007838	Glutamate-cysteine ligase; Region: GshA; pfam08886
568206007839	Protein of unknown function (DUF327); Region: DUF327; pfam03885
568206007840	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
568206007841	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
568206007842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206007843	flagellar motor switch protein; Reviewed; Region: PRK06782
568206007844	CheC-like family; Region: CheC; pfam04509
568206007845	CheC-like family; Region: CheC; pfam04509
568206007846	CheC-like family; Region: CheC; pfam04509
568206007847	CheC-like family; Region: CheC; pfam04509
568206007848	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
568206007849	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
568206007850	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
568206007851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206007852	ATP binding site [chemical binding]; other site
568206007853	Mg2+ binding site [ion binding]; other site
568206007854	G-X-G motif; other site
568206007855	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
568206007856	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
568206007857	putative binding surface; other site
568206007858	active site
568206007859	P2 response regulator binding domain; Region: P2; pfam07194
568206007860	Response regulator receiver domain; Region: Response_reg; pfam00072
568206007861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206007862	active site
568206007863	phosphorylation site [posttranslational modification]
568206007864	intermolecular recognition site; other site
568206007865	dimerization interface [polypeptide binding]; other site
568206007866	flagellar motor protein MotS; Reviewed; Region: PRK06742
568206007867	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
568206007868	ligand binding site [chemical binding]; other site
568206007869	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
568206007870	flagellar motor protein MotP; Reviewed; Region: PRK06743
568206007871	HD domain; Region: HD_3; pfam13023
568206007872	bacterial Hfq-like; Region: Hfq; cd01716
568206007873	hexamer interface [polypeptide binding]; other site
568206007874	Sm1 motif; other site
568206007875	RNA binding site [nucleotide binding]; other site
568206007876	Sm2 motif; other site
568206007877	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
568206007878	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206007879	active site
568206007880	metal binding site [ion binding]; metal-binding site
568206007881	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206007882	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206007883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206007884	putative substrate translocation pore; other site
568206007885	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206007886	dimerization interface [polypeptide binding]; other site
568206007887	putative DNA binding site [nucleotide binding]; other site
568206007888	putative Zn2+ binding site [ion binding]; other site
568206007889	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206007890	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206007891	putative substrate translocation pore; other site
568206007892	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
568206007893	DJ-1 family protein; Region: not_thiJ; TIGR01383
568206007894	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
568206007895	conserved cys residue [active]
568206007896	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
568206007897	dimer interface [polypeptide binding]; other site
568206007898	FMN binding site [chemical binding]; other site
568206007899	NADPH bind site [chemical binding]; other site
568206007900	Tic20-like protein; Region: Tic20; pfam09685
568206007901	Uncharacterized conserved protein [Function unknown]; Region: COG1434
568206007902	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568206007903	putative active site [active]
568206007904	Predicted membrane protein [Function unknown]; Region: COG2323
568206007905	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
568206007906	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
568206007907	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568206007908	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
568206007909	DNA binding residues [nucleotide binding]
568206007910	drug binding residues [chemical binding]; other site
568206007911	dimer interface [polypeptide binding]; other site
568206007912	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
568206007913	potential frameshift: common BLAST hit: gi|49184537|ref|YP_027789.1| metallo-beta-lactamase family protein
568206007914	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
568206007915	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
568206007916	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
568206007917	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206007918	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
568206007919	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
568206007920	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
568206007921	aminotransferase; Validated; Region: PRK07678
568206007922	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206007923	inhibitor-cofactor binding pocket; inhibition site
568206007924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206007925	catalytic residue [active]
568206007926	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
568206007927	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
568206007928	Na binding site [ion binding]; other site
568206007929	Protein of unknown function, DUF485; Region: DUF485; pfam04341
568206007930	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
568206007931	LysE type translocator; Region: LysE; pfam01810
568206007932	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
568206007933	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568206007934	DNA-binding site [nucleotide binding]; DNA binding site
568206007935	RNA-binding motif; other site
568206007936	Protein of unknown function (DUF2564); Region: DUF2564; pfam10819
568206007937	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
568206007938	hypothetical protein; Validated; Region: PRK07708
568206007939	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
568206007940	RNA/DNA hybrid binding site [nucleotide binding]; other site
568206007941	active site
568206007942	QueT transporter; Region: QueT; pfam06177
568206007943	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
568206007944	active site
568206007945	catalytic residues [active]
568206007946	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
568206007947	RNA/DNA hybrid binding site [nucleotide binding]; other site
568206007948	active site
568206007949	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206007950	EamA-like transporter family; Region: EamA; pfam00892
568206007951	EamA-like transporter family; Region: EamA; cl17759
568206007952	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
568206007953	Isochorismatase family; Region: Isochorismatase; pfam00857
568206007954	catalytic triad [active]
568206007955	conserved cis-peptide bond; other site
568206007956	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206007957	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206007958	Coenzyme A binding pocket [chemical binding]; other site
568206007959	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007960	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007961	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007962	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007963	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007964	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007965	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007966	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007967	Domain of unknown function DUF11; Region: DUF11; cl17728
568206007968	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007969	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007970	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007971	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007972	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007973	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007974	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007975	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007976	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007977	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007978	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007979	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007980	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007981	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007982	Domain of unknown function DUF11; Region: DUF11; cl17728
568206007983	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007984	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007985	conserved repeat domain; Region: B_ant_repeat; TIGR01451
568206007986	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
568206007987	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206007988	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
568206007989	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568206007990	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568206007991	active site
568206007992	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
568206007993	O-Antigen ligase; Region: Wzy_C; pfam04932
568206007994	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
568206007995	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
568206007996	Bacterial sugar transferase; Region: Bac_transf; pfam02397
568206007997	potential frameshift: common BLAST hit: gi|218902796|ref|YP_002450630.1| putative capsular polysaccharide biosynthesis protein tyrosine
568206007998	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
568206007999	Chain length determinant protein; Region: Wzz; cl15801
568206008000	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
568206008001	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
568206008002	5'-3' exonuclease; Region: 53EXOc; smart00475
568206008003	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
568206008004	active site
568206008005	metal binding site 1 [ion binding]; metal-binding site
568206008006	putative 5' ssDNA interaction site; other site
568206008007	metal binding site 3; metal-binding site
568206008008	metal binding site 2 [ion binding]; metal-binding site
568206008009	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
568206008010	putative DNA binding site [nucleotide binding]; other site
568206008011	putative metal binding site [ion binding]; other site
568206008012	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
568206008013	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568206008014	ykoK leader
568206008015	Predicted membrane protein [Function unknown]; Region: COG3766
568206008016	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
568206008017	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
568206008018	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
568206008019	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
568206008020	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
568206008021	active site residue [active]
568206008022	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
568206008023	active site residue [active]
568206008024	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
568206008025	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206008026	Coenzyme A binding pocket [chemical binding]; other site
568206008027	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
568206008028	Protein of unknown function (DUF3931); Region: DUF3931; pfam13082
568206008029	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
568206008030	Dynamin family; Region: Dynamin_N; pfam00350
568206008031	G1 box; other site
568206008032	GTP/Mg2+ binding site [chemical binding]; other site
568206008033	G2 box; other site
568206008034	Switch I region; other site
568206008035	G3 box; other site
568206008036	Switch II region; other site
568206008037	G4 box; other site
568206008038	G5 box; other site
568206008039	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
568206008040	Dynamin family; Region: Dynamin_N; pfam00350
568206008041	G1 box; other site
568206008042	GTP/Mg2+ binding site [chemical binding]; other site
568206008043	G2 box; other site
568206008044	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
568206008045	G3 box; other site
568206008046	Switch II region; other site
568206008047	GTP/Mg2+ binding site [chemical binding]; other site
568206008048	G4 box; other site
568206008049	G5 box; other site
568206008050	Predicted membrane protein [Function unknown]; Region: COG2311
568206008051	Protein of unknown function (DUF418); Region: DUF418; cl12135
568206008052	Protein of unknown function (DUF418); Region: DUF418; pfam04235
568206008053	xanthine permease; Region: pbuX; TIGR03173
568206008054	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206008055	active site
568206008056	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
568206008057	active site
568206008058	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
568206008059	Phosphotransferase enzyme family; Region: APH; pfam01636
568206008060	putative active site [active]
568206008061	putative substrate binding site [chemical binding]; other site
568206008062	ATP binding site [chemical binding]; other site
568206008063	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206008064	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206008065	Coenzyme A binding pocket [chemical binding]; other site
568206008066	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
568206008067	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
568206008068	active site
568206008069	Zn binding site [ion binding]; other site
568206008070	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
568206008071	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
568206008072	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
568206008073	Protein of unknown function (DUF3921); Region: DUF3921; pfam13060
568206008074	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
568206008075	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
568206008076	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
568206008077	cell division protein GpsB; Provisional; Region: PRK14127
568206008078	DivIVA domain; Region: DivI1A_domain; TIGR03544
568206008079	hypothetical protein; Provisional; Region: PRK13660
568206008080	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
568206008081	YppG-like protein; Region: YppG; pfam14179
568206008082	YppF-like protein; Region: YppF; pfam14178
568206008083	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
568206008084	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
568206008085	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
568206008086	Transglycosylase; Region: Transgly; pfam00912
568206008087	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568206008088	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
568206008089	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
568206008090	Interdomain contacts; other site
568206008091	Cytokine receptor motif; other site
568206008092	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
568206008093	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568206008094	minor groove reading motif; other site
568206008095	helix-hairpin-helix signature motif; other site
568206008096	substrate binding pocket [chemical binding]; other site
568206008097	active site
568206008098	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
568206008099	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
568206008100	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
568206008101	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
568206008102	aspartate aminotransferase; Provisional; Region: PRK05764
568206008103	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206008104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206008105	homodimer interface [polypeptide binding]; other site
568206008106	catalytic residue [active]
568206008107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
568206008108	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
568206008109	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
568206008110	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
568206008111	active site
568206008112	catalytic site [active]
568206008113	substrate binding site [chemical binding]; other site
568206008114	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
568206008115	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206008116	nucleotide binding region [chemical binding]; other site
568206008117	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
568206008118	tetramerization interface [polypeptide binding]; other site
568206008119	active site
568206008120	pantoate--beta-alanine ligase; Region: panC; TIGR00018
568206008121	Pantoate-beta-alanine ligase; Region: PanC; cd00560
568206008122	active site
568206008123	ATP-binding site [chemical binding]; other site
568206008124	pantoate-binding site; other site
568206008125	HXXH motif; other site
568206008126	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
568206008127	oligomerization interface [polypeptide binding]; other site
568206008128	active site
568206008129	metal binding site [ion binding]; metal-binding site
568206008130	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
568206008131	Biotin operon repressor [Transcription]; Region: BirA; COG1654
568206008132	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
568206008133	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
568206008134	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
568206008135	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
568206008136	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
568206008137	active site
568206008138	NTP binding site [chemical binding]; other site
568206008139	metal binding triad [ion binding]; metal-binding site
568206008140	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
568206008141	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
568206008142	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
568206008143	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
568206008144	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
568206008145	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
568206008146	active site
568206008147	dimer interfaces [polypeptide binding]; other site
568206008148	catalytic residues [active]
568206008149	dihydrodipicolinate reductase; Provisional; Region: PRK00048
568206008150	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
568206008151	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
568206008152	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
568206008153	homodimer interface [polypeptide binding]; other site
568206008154	metal binding site [ion binding]; metal-binding site
568206008155	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206008156	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206008157	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206008158	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206008159	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
568206008160	active site
568206008161	Fe-S cluster binding site [ion binding]; other site
568206008162	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
568206008163	sporulation protein YpjB; Region: spore_ypjB; TIGR02878
568206008164	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
568206008165	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
568206008166	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
568206008167	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
568206008168	interchain domain interface [polypeptide binding]; other site
568206008169	intrachain domain interface; other site
568206008170	Qi binding site; other site
568206008171	Qo binding site; other site
568206008172	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
568206008173	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
568206008174	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
568206008175	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
568206008176	interchain domain interface [polypeptide binding]; other site
568206008177	intrachain domain interface; other site
568206008178	heme bH binding site [chemical binding]; other site
568206008179	Qi binding site; other site
568206008180	heme bL binding site [chemical binding]; other site
568206008181	Qo binding site; other site
568206008182	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
568206008183	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
568206008184	iron-sulfur cluster [ion binding]; other site
568206008185	[2Fe-2S] cluster binding site [ion binding]; other site
568206008186	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
568206008187	hypothetical protein; Provisional; Region: PRK03636
568206008188	UPF0302 domain; Region: UPF0302; pfam08864
568206008189	IDEAL domain; Region: IDEAL; pfam08858
568206008190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206008191	binding surface
568206008192	TPR motif; other site
568206008193	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
568206008194	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206008195	binding surface
568206008196	TPR motif; other site
568206008197	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206008198	TPR repeat; Region: TPR_11; pfam13414
568206008199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206008200	binding surface
568206008201	TPR motif; other site
568206008202	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
568206008203	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206008204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206008205	homodimer interface [polypeptide binding]; other site
568206008206	catalytic residue [active]
568206008207	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
568206008208	active site
568206008209	dimer interface [polypeptide binding]; other site
568206008210	metal binding site [ion binding]; metal-binding site
568206008211	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
568206008212	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
568206008213	Tetramer interface [polypeptide binding]; other site
568206008214	active site
568206008215	FMN-binding site [chemical binding]; other site
568206008216	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
568206008217	active site
568206008218	multimer interface [polypeptide binding]; other site
568206008219	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
568206008220	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
568206008221	substrate binding pocket [chemical binding]; other site
568206008222	chain length determination region; other site
568206008223	substrate-Mg2+ binding site; other site
568206008224	catalytic residues [active]
568206008225	aspartate-rich region 1; other site
568206008226	active site lid residues [active]
568206008227	aspartate-rich region 2; other site
568206008228	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
568206008229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206008230	S-adenosylmethionine binding site [chemical binding]; other site
568206008231	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
568206008232	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
568206008233	homodecamer interface [polypeptide binding]; other site
568206008234	GTP cyclohydrolase I; Provisional; Region: PLN03044
568206008235	active site
568206008236	putative catalytic site residues [active]
568206008237	zinc binding site [ion binding]; other site
568206008238	GTP-CH-I/GFRP interaction surface; other site
568206008239	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
568206008240	IHF dimer interface [polypeptide binding]; other site
568206008241	IHF - DNA interface [nucleotide binding]; other site
568206008242	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
568206008243	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
568206008244	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
568206008245	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
568206008246	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
568206008247	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
568206008248	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
568206008249	GTP-binding protein Der; Reviewed; Region: PRK00093
568206008250	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
568206008251	G1 box; other site
568206008252	GTP/Mg2+ binding site [chemical binding]; other site
568206008253	Switch I region; other site
568206008254	G2 box; other site
568206008255	Switch II region; other site
568206008256	G3 box; other site
568206008257	G4 box; other site
568206008258	G5 box; other site
568206008259	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
568206008260	G1 box; other site
568206008261	GTP/Mg2+ binding site [chemical binding]; other site
568206008262	Switch I region; other site
568206008263	G2 box; other site
568206008264	G3 box; other site
568206008265	Switch II region; other site
568206008266	G4 box; other site
568206008267	G5 box; other site
568206008268	YIEGIA protein; Region: YIEGIA; pfam14045
568206008269	YpzI-like protein; Region: YpzI; pfam14140
568206008270	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
568206008271	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
568206008272	homotetramer interface [polypeptide binding]; other site
568206008273	FMN binding site [chemical binding]; other site
568206008274	homodimer contacts [polypeptide binding]; other site
568206008275	putative active site [active]
568206008276	putative substrate binding site [chemical binding]; other site
568206008277	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
568206008278	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
568206008279	RNA binding site [nucleotide binding]; other site
568206008280	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
568206008281	RNA binding site [nucleotide binding]; other site
568206008282	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
568206008283	RNA binding site [nucleotide binding]; other site
568206008284	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
568206008285	RNA binding site [nucleotide binding]; other site
568206008286	cytidylate kinase; Provisional; Region: cmk; PRK00023
568206008287	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
568206008288	CMP-binding site; other site
568206008289	The sites determining sugar specificity; other site
568206008290	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
568206008291	active site
568206008292	homodimer interface [polypeptide binding]; other site
568206008293	homotetramer interface [polypeptide binding]; other site
568206008294	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
568206008295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
568206008296	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206008297	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
568206008298	amidase catalytic site [active]
568206008299	Zn binding residues [ion binding]; other site
568206008300	substrate binding site [chemical binding]; other site
568206008301	Domain of unknown function (DUF3961); Region: DUF3961; pfam13106
568206008302	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
568206008303	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
568206008304	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
568206008305	NAD(P) binding site [chemical binding]; other site
568206008306	adaptor protein; Provisional; Region: PRK02899
568206008307	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206008308	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
568206008309	DNA binding residues [nucleotide binding]
568206008310	B12 binding domain; Region: B12-binding_2; pfam02607
568206008311	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
568206008312	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
568206008313	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
568206008314	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206008315	active site
568206008316	metal binding site [ion binding]; metal-binding site
568206008317	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568206008318	CAAX protease self-immunity; Region: Abi; pfam02517
568206008319	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568206008320	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206008321	ATP binding site [chemical binding]; other site
568206008322	putative Mg++ binding site [ion binding]; other site
568206008323	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206008324	nucleotide binding region [chemical binding]; other site
568206008325	ATP-binding site [chemical binding]; other site
568206008326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
568206008327	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
568206008328	Predicted membrane protein [Function unknown]; Region: COG3601
568206008329	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
568206008330	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206008331	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206008332	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
568206008333	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568206008334	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
568206008335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
568206008336	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206008337	dimerization interface [polypeptide binding]; other site
568206008338	PAS domain; Region: PAS; smart00091
568206008339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206008340	dimer interface [polypeptide binding]; other site
568206008341	phosphorylation site [posttranslational modification]
568206008342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206008343	ATP binding site [chemical binding]; other site
568206008344	Mg2+ binding site [ion binding]; other site
568206008345	G-X-G motif; other site
568206008346	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206008347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206008348	active site
568206008349	phosphorylation site [posttranslational modification]
568206008350	intermolecular recognition site; other site
568206008351	dimerization interface [polypeptide binding]; other site
568206008352	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206008353	DNA binding site [nucleotide binding]
568206008354	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
568206008355	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
568206008356	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
568206008357	ResB-like family; Region: ResB; pfam05140
568206008358	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
568206008359	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
568206008360	catalytic residues [active]
568206008361	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
568206008362	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206008363	RNA binding surface [nucleotide binding]; other site
568206008364	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
568206008365	active site
568206008366	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
568206008367	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
568206008368	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206008369	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
568206008370	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
568206008371	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
568206008372	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
568206008373	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
568206008374	Predicted integral membrane protein [Function unknown]; Region: COG0392
568206008375	Uncharacterized conserved protein [Function unknown]; Region: COG2898
568206008376	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
568206008377	Probable transposase; Region: OrfB_IS605; pfam01385
568206008378	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
568206008379	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
568206008380	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
568206008381	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
568206008382	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206008383	dimerization interface [polypeptide binding]; other site
568206008384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206008385	dimer interface [polypeptide binding]; other site
568206008386	phosphorylation site [posttranslational modification]
568206008387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206008388	ATP binding site [chemical binding]; other site
568206008389	Mg2+ binding site [ion binding]; other site
568206008390	G-X-G motif; other site
568206008391	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
568206008392	active site
568206008393	DNA binding site [nucleotide binding]
568206008394	Int/Topo IB signature motif; other site
568206008395	Protein of unknown function (DUF3924); Region: DUF3924; pfam13062
568206008396	Protein of unknown function DUF72; Region: DUF72; pfam01904
568206008397	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
568206008398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206008399	putative active site [active]
568206008400	heme pocket [chemical binding]; other site
568206008401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206008402	dimer interface [polypeptide binding]; other site
568206008403	phosphorylation site [posttranslational modification]
568206008404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206008405	ATP binding site [chemical binding]; other site
568206008406	Mg2+ binding site [ion binding]; other site
568206008407	G-X-G motif; other site
568206008408	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
568206008409	Transglycosylase; Region: Transgly; pfam00912
568206008410	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568206008411	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206008412	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
568206008413	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
568206008414	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
568206008415	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568206008416	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568206008417	ligand binding site [chemical binding]; other site
568206008418	flexible hinge region; other site
568206008419	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
568206008420	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
568206008421	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
568206008422	heme-binding site [chemical binding]; other site
568206008423	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
568206008424	FAD binding pocket [chemical binding]; other site
568206008425	FAD binding motif [chemical binding]; other site
568206008426	phosphate binding motif [ion binding]; other site
568206008427	beta-alpha-beta structure motif; other site
568206008428	NAD binding pocket [chemical binding]; other site
568206008429	Heme binding  pocket [chemical binding]; other site
568206008430	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
568206008431	Peptidase family M50; Region: Peptidase_M50; pfam02163
568206008432	active site
568206008433	putative substrate binding region [chemical binding]; other site
568206008434	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206008435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206008436	S-adenosylmethionine binding site [chemical binding]; other site
568206008437	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
568206008438	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568206008439	E3 interaction surface; other site
568206008440	lipoyl attachment site [posttranslational modification]; other site
568206008441	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568206008442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206008443	active site
568206008444	phosphorylation site [posttranslational modification]
568206008445	intermolecular recognition site; other site
568206008446	dimerization interface [polypeptide binding]; other site
568206008447	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
568206008448	DNA binding residues [nucleotide binding]
568206008449	dimerization interface [polypeptide binding]; other site
568206008450	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
568206008451	Histidine kinase; Region: HisKA_3; pfam07730
568206008452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206008453	ATP binding site [chemical binding]; other site
568206008454	Mg2+ binding site [ion binding]; other site
568206008455	G-X-G motif; other site
568206008456	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
568206008457	PspA/IM30 family; Region: PspA_IM30; pfam04012
568206008458	Vpu protein; Region: Vpu; pfam00558
568206008459	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
568206008460	Protein of unknown function (DUF402); Region: DUF402; cl00979
568206008461	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
568206008462	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
568206008463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
568206008464	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206008465	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206008466	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
568206008467	Na2 binding site [ion binding]; other site
568206008468	putative substrate binding site 1 [chemical binding]; other site
568206008469	Na binding site 1 [ion binding]; other site
568206008470	putative substrate binding site 2 [chemical binding]; other site
568206008471	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
568206008472	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
568206008473	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
568206008474	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
568206008475	putative active site [active]
568206008476	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
568206008477	putative active site [active]
568206008478	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
568206008479	diphthine synthase; Region: dph5; TIGR00522
568206008480	active site
568206008481	SAM binding site [chemical binding]; other site
568206008482	homodimer interface [polypeptide binding]; other site
568206008483	Protein of unknown function (DUF3906); Region: DUF3906; pfam13046
568206008484	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
568206008485	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
568206008486	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
568206008487	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
568206008488	ligand-binding site [chemical binding]; other site
568206008489	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
568206008490	ATP-sulfurylase; Region: ATPS; cd00517
568206008491	active site
568206008492	HXXH motif; other site
568206008493	flexible loop; other site
568206008494	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
568206008495	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
568206008496	Active Sites [active]
568206008497	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
568206008498	diaminopimelate decarboxylase; Region: lysA; TIGR01048
568206008499	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
568206008500	active site
568206008501	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568206008502	substrate binding site [chemical binding]; other site
568206008503	catalytic residues [active]
568206008504	dimer interface [polypeptide binding]; other site
568206008505	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
568206008506	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
568206008507	Sulfatase; Region: Sulfatase; pfam00884
568206008508	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
568206008509	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
568206008510	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
568206008511	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
568206008512	putative ligand binding site [chemical binding]; other site
568206008513	putative NAD binding site [chemical binding]; other site
568206008514	catalytic site [active]
568206008515	histidinol-phosphatase; Validated; Region: PRK06740
568206008516	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
568206008517	dimer interface [polypeptide binding]; other site
568206008518	active site
568206008519	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
568206008520	metal binding site [ion binding]; metal-binding site
568206008521	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
568206008522	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
568206008523	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
568206008524	substrate binding site [chemical binding]; other site
568206008525	glutamase interaction surface [polypeptide binding]; other site
568206008526	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
568206008527	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
568206008528	catalytic residues [active]
568206008529	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
568206008530	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
568206008531	putative active site [active]
568206008532	oxyanion strand; other site
568206008533	catalytic triad [active]
568206008534	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
568206008535	putative active site pocket [active]
568206008536	4-fold oligomerization interface [polypeptide binding]; other site
568206008537	metal binding residues [ion binding]; metal-binding site
568206008538	3-fold/trimer interface [polypeptide binding]; other site
568206008539	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
568206008540	histidinol dehydrogenase; Region: hisD; TIGR00069
568206008541	NAD binding site [chemical binding]; other site
568206008542	dimerization interface [polypeptide binding]; other site
568206008543	product binding site; other site
568206008544	substrate binding site [chemical binding]; other site
568206008545	zinc binding site [ion binding]; other site
568206008546	catalytic residues [active]
568206008547	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
568206008548	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
568206008549	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
568206008550	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
568206008551	dimer interface [polypeptide binding]; other site
568206008552	motif 1; other site
568206008553	active site
568206008554	motif 2; other site
568206008555	motif 3; other site
568206008556	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
568206008557	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
568206008558	substrate binding site [chemical binding]; other site
568206008559	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
568206008560	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
568206008561	substrate binding site [chemical binding]; other site
568206008562	ligand binding site [chemical binding]; other site
568206008563	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
568206008564	tartrate dehydrogenase; Region: TTC; TIGR02089
568206008565	2-isopropylmalate synthase; Validated; Region: PRK00915
568206008566	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
568206008567	active site
568206008568	catalytic residues [active]
568206008569	metal binding site [ion binding]; metal-binding site
568206008570	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
568206008571	ketol-acid reductoisomerase; Provisional; Region: PRK05479
568206008572	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
568206008573	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
568206008574	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
568206008575	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
568206008576	putative valine binding site [chemical binding]; other site
568206008577	dimer interface [polypeptide binding]; other site
568206008578	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
568206008579	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
568206008580	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568206008581	PYR/PP interface [polypeptide binding]; other site
568206008582	dimer interface [polypeptide binding]; other site
568206008583	TPP binding site [chemical binding]; other site
568206008584	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568206008585	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
568206008586	TPP-binding site [chemical binding]; other site
568206008587	dimer interface [polypeptide binding]; other site
568206008588	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
568206008589	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
568206008590	homodimer interface [polypeptide binding]; other site
568206008591	substrate-cofactor binding pocket; other site
568206008592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206008593	catalytic residue [active]
568206008594	Protein of unknown function (DUF3911); Region: DUF3911; pfam13050
568206008595	hypothetical protein; Provisional; Region: PRK03094
568206008596	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
568206008597	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
568206008598	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
568206008599	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
568206008600	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
568206008601	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206008602	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
568206008603	Regulatory protein YrvL; Region: YrvL; pfam14184
568206008604	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568206008605	catalytic residues [active]
568206008606	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
568206008607	multidrug efflux protein; Reviewed; Region: PRK01766
568206008608	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
568206008609	cation binding site [ion binding]; other site
568206008610	Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908
568206008611	Phosphotransferase enzyme family; Region: APH; pfam01636
568206008612	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
568206008613	active site
568206008614	substrate binding site [chemical binding]; other site
568206008615	ATP binding site [chemical binding]; other site
568206008616	flavodoxin; Provisional; Region: PRK06756
568206008617	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
568206008618	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568206008619	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
568206008620	metal binding site [ion binding]; metal-binding site
568206008621	dimer interface [polypeptide binding]; other site
568206008622	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
568206008623	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
568206008624	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
568206008625	acyl-activating enzyme (AAE) consensus motif; other site
568206008626	AMP binding site [chemical binding]; other site
568206008627	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
568206008628	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
568206008629	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
568206008630	DltD N-terminal region; Region: DltD_N; pfam04915
568206008631	DltD central region; Region: DltD_M; pfam04918
568206008632	DltD C-terminal region; Region: DltD_C; pfam04914
568206008633	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
568206008634	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
568206008635	FMN binding site [chemical binding]; other site
568206008636	substrate binding site [chemical binding]; other site
568206008637	putative catalytic residue [active]
568206008638	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
568206008639	dimer interface [polypeptide binding]; other site
568206008640	catalytic triad [active]
568206008641	SseB protein; Region: SseB; cl06279
568206008642	Isochorismatase family; Region: Isochorismatase; pfam00857
568206008643	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
568206008644	catalytic triad [active]
568206008645	conserved cis-peptide bond; other site
568206008646	Uncharacterized conserved protein [Function unknown]; Region: COG2128
568206008647	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
568206008648	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206008649	putative DNA binding site [nucleotide binding]; other site
568206008650	putative Zn2+ binding site [ion binding]; other site
568206008651	AsnC family; Region: AsnC_trans_reg; pfam01037
568206008652	Protein of unknown function (DUF3913); Region: DUF3913; pfam13052
568206008653	CAAX protease self-immunity; Region: Abi; pfam02517
568206008654	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
568206008655	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
568206008656	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568206008657	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206008658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206008659	Walker A/P-loop; other site
568206008660	ATP binding site [chemical binding]; other site
568206008661	Q-loop/lid; other site
568206008662	ABC transporter signature motif; other site
568206008663	Walker B; other site
568206008664	D-loop; other site
568206008665	H-loop/switch region; other site
568206008666	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568206008667	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206008668	Walker A/P-loop; other site
568206008669	ATP binding site [chemical binding]; other site
568206008670	Q-loop/lid; other site
568206008671	ABC transporter signature motif; other site
568206008672	Walker B; other site
568206008673	D-loop; other site
568206008674	H-loop/switch region; other site
568206008675	Predicted transcriptional regulators [Transcription]; Region: COG1725
568206008676	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206008677	DNA-binding site [nucleotide binding]; DNA binding site
568206008678	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
568206008679	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
568206008680	dimer interface [polypeptide binding]; other site
568206008681	putative radical transfer pathway; other site
568206008682	diiron center [ion binding]; other site
568206008683	tyrosyl radical; other site
568206008684	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
568206008685	N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437
568206008686	group I intron endonuclease; Region: grpIintron_endo; TIGR01453
568206008687	GIY-YIG motif/motif A; other site
568206008688	putative active site [active]
568206008689	catalytic site [active]
568206008690	putative metal binding site [ion binding]; other site
568206008691	GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508
568206008692	DNA binding site [nucleotide binding]
568206008693	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
568206008694	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
568206008695	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
568206008696	potential frameshift: common BLAST hit: gi|218902554|ref|YP_002450388.1| acetyltransferase, GNAT family
568206008697	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568206008698	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206008699	Coenzyme A binding pocket [chemical binding]; other site
568206008700	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
568206008701	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953
568206008702	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
568206008703	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
568206008704	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
568206008705	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
568206008706	active site
568206008707	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
568206008708	Ligand Binding Site [chemical binding]; other site
568206008709	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
568206008710	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206008711	dimer interface [polypeptide binding]; other site
568206008712	phosphorylation site [posttranslational modification]
568206008713	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206008714	ATP binding site [chemical binding]; other site
568206008715	Mg2+ binding site [ion binding]; other site
568206008716	G-X-G motif; other site
568206008717	DinB superfamily; Region: DinB_2; pfam12867
568206008718	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
568206008719	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
568206008720	active site
568206008721	Zn binding site [ion binding]; other site
568206008722	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206008723	MarR family; Region: MarR; pfam01047
568206008724	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
568206008725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206008726	dimer interface [polypeptide binding]; other site
568206008727	phosphorylation site [posttranslational modification]
568206008728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206008729	ATP binding site [chemical binding]; other site
568206008730	Mg2+ binding site [ion binding]; other site
568206008731	G-X-G motif; other site
568206008732	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
568206008733	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
568206008734	NodB motif; other site
568206008735	putative active site [active]
568206008736	putative catalytic site [active]
568206008737	Zn binding site [ion binding]; other site
568206008738	FOG: CBS domain [General function prediction only]; Region: COG0517
568206008739	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
568206008740	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
568206008741	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
568206008742	Leucine rich repeat; Region: LRR_8; pfam13855
568206008743	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568206008744	Leucine rich repeat; Region: LRR_8; pfam13855
568206008745	Leucine-rich repeats; other site
568206008746	Substrate binding site [chemical binding]; other site
568206008747	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206008748	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206008749	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206008750	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206008751	S-layer homology domain; Region: SLH; pfam00395
568206008752	S-layer homology domain; Region: SLH; pfam00395
568206008753	S-layer homology domain; Region: SLH; pfam00395
568206008754	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206008755	heme-binding site [chemical binding]; other site
568206008756	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760
568206008757	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568206008758	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
568206008759	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568206008760	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
568206008761	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
568206008762	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206008763	catalytic residue [active]
568206008764	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
568206008765	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206008766	motif II; other site
568206008767	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
568206008768	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206008769	dimer interface [polypeptide binding]; other site
568206008770	conserved gate region; other site
568206008771	putative PBP binding loops; other site
568206008772	ABC-ATPase subunit interface; other site
568206008773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206008774	dimer interface [polypeptide binding]; other site
568206008775	conserved gate region; other site
568206008776	putative PBP binding loops; other site
568206008777	ABC-ATPase subunit interface; other site
568206008778	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206008779	ABC transporter signature motif; other site
568206008780	Walker B; other site
568206008781	D-loop; other site
568206008782	H-loop/switch region; other site
568206008783	TOBE domain; Region: TOBE_2; pfam08402
568206008784	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206008785	Q-loop/lid; other site
568206008786	putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261
568206008787	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
568206008788	Protein of unknown function (DUF3905); Region: DUF3905; pfam13045
568206008789	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
568206008790	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
568206008791	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
568206008792	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
568206008793	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
568206008794	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
568206008795	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
568206008796	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
568206008797	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
568206008798	NAD(P) binding site [chemical binding]; other site
568206008799	homotetramer interface [polypeptide binding]; other site
568206008800	homodimer interface [polypeptide binding]; other site
568206008801	active site
568206008802	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
568206008803	poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719
568206008804	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206008805	Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820
568206008806	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
568206008807	dimer interaction site [polypeptide binding]; other site
568206008808	substrate-binding tunnel; other site
568206008809	active site
568206008810	catalytic site [active]
568206008811	substrate binding site [chemical binding]; other site
568206008812	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
568206008813	potential frameshift: common BLAST hit: gi|218902516|ref|YP_002450350.1| potassium uptake protein, TrkH family
568206008814	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
568206008815	Cation transport protein; Region: TrkH; cl17365
568206008816	yybP-ykoY leader
568206008817	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
568206008818	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
568206008819	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
568206008820	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
568206008821	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
568206008822	Uncharacterized conserved protein [Function unknown]; Region: COG1556
568206008823	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
568206008824	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
568206008825	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
568206008826	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
568206008827	Cysteine-rich domain; Region: CCG; pfam02754
568206008828	Cysteine-rich domain; Region: CCG; pfam02754
568206008829	Transcriptional regulators [Transcription]; Region: FadR; COG2186
568206008830	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206008831	DNA-binding site [nucleotide binding]; DNA binding site
568206008832	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
568206008833	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
568206008834	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206008835	dimerization interface [polypeptide binding]; other site
568206008836	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206008837	dimer interface [polypeptide binding]; other site
568206008838	phosphorylation site [posttranslational modification]
568206008839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206008840	ATP binding site [chemical binding]; other site
568206008841	Mg2+ binding site [ion binding]; other site
568206008842	G-X-G motif; other site
568206008843	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206008844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206008845	active site
568206008846	phosphorylation site [posttranslational modification]
568206008847	intermolecular recognition site; other site
568206008848	dimerization interface [polypeptide binding]; other site
568206008849	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206008850	DNA binding site [nucleotide binding]
568206008851	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
568206008852	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
568206008853	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
568206008854	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
568206008855	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
568206008856	FAD binding domain; Region: FAD_binding_4; pfam01565
568206008857	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
568206008858	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
568206008859	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
568206008860	Cysteine-rich domain; Region: CCG; pfam02754
568206008861	Cysteine-rich domain; Region: CCG; pfam02754
568206008862	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
568206008863	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
568206008864	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
568206008865	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
568206008866	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
568206008867	active site
568206008868	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
568206008869	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
568206008870	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
568206008871	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
568206008872	active site
568206008873	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
568206008874	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
568206008875	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
568206008876	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206008877	dimer interface [polypeptide binding]; other site
568206008878	conserved gate region; other site
568206008879	putative PBP binding loops; other site
568206008880	ABC-ATPase subunit interface; other site
568206008881	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
568206008882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206008883	dimer interface [polypeptide binding]; other site
568206008884	conserved gate region; other site
568206008885	putative PBP binding loops; other site
568206008886	ABC-ATPase subunit interface; other site
568206008887	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
568206008888	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
568206008889	Walker A/P-loop; other site
568206008890	ATP binding site [chemical binding]; other site
568206008891	Q-loop/lid; other site
568206008892	ABC transporter signature motif; other site
568206008893	Walker B; other site
568206008894	D-loop; other site
568206008895	H-loop/switch region; other site
568206008896	TOBE domain; Region: TOBE_2; pfam08402
568206008897	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
568206008898	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
568206008899	NAD(P) binding site [chemical binding]; other site
568206008900	catalytic residues [active]
568206008901	potential frameshift: common BLAST hit: gi|218902490|ref|YP_002450324.1| immune inhibitor A metalloprotease InhA1
568206008902	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
568206008903	Anti-repressor SinI; Region: SinI; pfam08671
568206008904	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206008905	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206008906	non-specific DNA binding site [nucleotide binding]; other site
568206008907	salt bridge; other site
568206008908	sequence-specific DNA binding site [nucleotide binding]; other site
568206008909	Anti-repressor SinI; Region: SinI; pfam08671
568206008910	Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389
568206008911	Domain of unknown function (DUF4047); Region: DUF4047; pfam13256
568206008912	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
568206008913	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
568206008914	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206008915	Catalytic site [active]
568206008916	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206008917	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
568206008918	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
568206008919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206008920	S-adenosylmethionine binding site [chemical binding]; other site
568206008921	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
568206008922	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
568206008923	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
568206008924	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
568206008925	Domain of unknown function (DUF3976); Region: DUF3976; pfam13121
568206008926	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206008927	salt bridge; other site
568206008928	non-specific DNA binding site [nucleotide binding]; other site
568206008929	sequence-specific DNA binding site [nucleotide binding]; other site
568206008930	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
568206008931	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
568206008932	TPP-binding site [chemical binding]; other site
568206008933	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
568206008934	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
568206008935	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568206008936	E3 interaction surface; other site
568206008937	lipoyl attachment site [posttranslational modification]; other site
568206008938	e3 binding domain; Region: E3_binding; pfam02817
568206008939	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
568206008940	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
568206008941	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
568206008942	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
568206008943	YcaO-like family; Region: YcaO; pfam02624
568206008944	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
568206008945	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
568206008946	NADPH bind site [chemical binding]; other site
568206008947	putative FMN binding site [chemical binding]; other site
568206008948	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
568206008949	putative FMN binding site [chemical binding]; other site
568206008950	NADPH bind site [chemical binding]; other site
568206008951	Protein of unknown function (DUF3908); Region: DUF3908; pfam13048
568206008952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206008953	Coenzyme A binding pocket [chemical binding]; other site
568206008954	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206008955	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
568206008956	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206008957	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568206008958	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
568206008959	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
568206008960	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
568206008961	L-lactate permease; Region: Lactate_perm; cl00701
568206008962	Protein of unknown function (DUF4029); Region: DUF4029; pfam13221
568206008963	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
568206008964	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
568206008965	substrate binding site [chemical binding]; other site
568206008966	active site
568206008967	catalytic residues [active]
568206008968	heterodimer interface [polypeptide binding]; other site
568206008969	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
568206008970	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
568206008971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206008972	catalytic residue [active]
568206008973	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
568206008974	active site
568206008975	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
568206008976	active site
568206008977	ribulose/triose binding site [chemical binding]; other site
568206008978	phosphate binding site [ion binding]; other site
568206008979	substrate (anthranilate) binding pocket [chemical binding]; other site
568206008980	product (indole) binding pocket [chemical binding]; other site
568206008981	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
568206008982	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
568206008983	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
568206008984	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
568206008985	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
568206008986	glutamine binding [chemical binding]; other site
568206008987	catalytic triad [active]
568206008988	anthranilate synthase component I; Provisional; Region: PRK13570
568206008989	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
568206008990	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
568206008991	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
568206008992	Na binding site [ion binding]; other site
568206008993	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
568206008994	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
568206008995	EamA-like transporter family; Region: EamA; pfam00892
568206008996	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
568206008997	EamA-like transporter family; Region: EamA; pfam00892
568206008998	Putative esterase; Region: Esterase; pfam00756
568206008999	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
568206009000	hypothetical protein; Provisional; Region: PRK13679
568206009001	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
568206009002	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
568206009003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206009004	Coenzyme A binding pocket [chemical binding]; other site
568206009005	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
568206009006	Part of AAA domain; Region: AAA_19; pfam13245
568206009007	Family description; Region: UvrD_C_2; pfam13538
568206009008	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
568206009009	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
568206009010	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
568206009011	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
568206009012	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
568206009013	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
568206009014	NAD binding site [chemical binding]; other site
568206009015	homotetramer interface [polypeptide binding]; other site
568206009016	homodimer interface [polypeptide binding]; other site
568206009017	substrate binding site [chemical binding]; other site
568206009018	active site
568206009019	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
568206009020	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
568206009021	NADP binding site [chemical binding]; other site
568206009022	active site
568206009023	putative substrate binding site [chemical binding]; other site
568206009024	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
568206009025	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
568206009026	NAD binding site [chemical binding]; other site
568206009027	substrate binding site [chemical binding]; other site
568206009028	homodimer interface [polypeptide binding]; other site
568206009029	active site
568206009030	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
568206009031	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206009032	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
568206009033	active site
568206009034	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
568206009035	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
568206009036	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206009037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206009038	S-adenosylmethionine binding site [chemical binding]; other site
568206009039	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
568206009040	putative metal binding site; other site
568206009041	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206009042	binding surface
568206009043	TPR motif; other site
568206009044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
568206009045	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206009046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206009047	S-adenosylmethionine binding site [chemical binding]; other site
568206009048	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
568206009049	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568206009050	active site
568206009051	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
568206009052	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
568206009053	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
568206009054	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
568206009055	active site
568206009056	metal binding site [ion binding]; metal-binding site
568206009057	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
568206009058	trimer interface [polypeptide binding]; other site
568206009059	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
568206009060	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
568206009061	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
568206009062	active site
568206009063	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
568206009064	ATP-NAD kinase; Region: NAD_kinase; pfam01513
568206009065	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568206009066	synthetase active site [active]
568206009067	NTP binding site [chemical binding]; other site
568206009068	metal binding site [ion binding]; metal-binding site
568206009069	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
568206009070	putative active site [active]
568206009071	putative metal binding residues [ion binding]; other site
568206009072	signature motif; other site
568206009073	putative triphosphate binding site [ion binding]; other site
568206009074	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
568206009075	apolar tunnel; other site
568206009076	heme binding site [chemical binding]; other site
568206009077	dimerization interface [polypeptide binding]; other site
568206009078	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
568206009079	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
568206009080	catalytic residues [active]
568206009081	oligoendopeptidase F; Region: pepF; TIGR00181
568206009082	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
568206009083	active site
568206009084	Zn binding site [ion binding]; other site
568206009085	Competence protein CoiA-like family; Region: CoiA; cl11541
568206009086	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
568206009087	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
568206009088	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568206009089	putative active site [active]
568206009090	catalytic site [active]
568206009091	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568206009092	putative active site [active]
568206009093	catalytic site [active]
568206009094	adaptor protein; Provisional; Region: PRK02315
568206009095	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
568206009096	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
568206009097	ArsC family; Region: ArsC; pfam03960
568206009098	putative catalytic residues [active]
568206009099	thiol/disulfide switch; other site
568206009100	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206009101	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206009102	peptide binding site [polypeptide binding]; other site
568206009103	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568206009104	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
568206009105	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
568206009106	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206009107	Walker A/P-loop; other site
568206009108	ATP binding site [chemical binding]; other site
568206009109	Q-loop/lid; other site
568206009110	ABC transporter signature motif; other site
568206009111	Walker B; other site
568206009112	D-loop; other site
568206009113	H-loop/switch region; other site
568206009114	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568206009115	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568206009116	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206009117	Walker A/P-loop; other site
568206009118	ATP binding site [chemical binding]; other site
568206009119	Q-loop/lid; other site
568206009120	ABC transporter signature motif; other site
568206009121	Walker B; other site
568206009122	D-loop; other site
568206009123	H-loop/switch region; other site
568206009124	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568206009125	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
568206009126	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
568206009127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206009128	dimer interface [polypeptide binding]; other site
568206009129	conserved gate region; other site
568206009130	putative PBP binding loops; other site
568206009131	ABC-ATPase subunit interface; other site
568206009132	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206009133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206009134	dimer interface [polypeptide binding]; other site
568206009135	conserved gate region; other site
568206009136	putative PBP binding loops; other site
568206009137	ABC-ATPase subunit interface; other site
568206009138	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568206009139	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568206009140	peptide binding site [polypeptide binding]; other site
568206009141	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
568206009142	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
568206009143	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
568206009144	active site
568206009145	HIGH motif; other site
568206009146	dimer interface [polypeptide binding]; other site
568206009147	KMSKS motif; other site
568206009148	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
568206009149	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
568206009150	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
568206009151	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
568206009152	dimer interface [polypeptide binding]; other site
568206009153	active site
568206009154	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
568206009155	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
568206009156	dimer interface [polypeptide binding]; other site
568206009157	active site
568206009158	CoA binding pocket [chemical binding]; other site
568206009159	ComZ; Region: ComZ; pfam10815
568206009160	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
568206009161	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206009162	NAD(P) binding site [chemical binding]; other site
568206009163	active site
568206009164	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
568206009165	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
568206009166	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
568206009167	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
568206009168	Clp amino terminal domain; Region: Clp_N; pfam02861
568206009169	Clp amino terminal domain; Region: Clp_N; pfam02861
568206009170	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206009171	Walker A motif; other site
568206009172	ATP binding site [chemical binding]; other site
568206009173	Walker B motif; other site
568206009174	arginine finger; other site
568206009175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206009176	Walker A motif; other site
568206009177	ATP binding site [chemical binding]; other site
568206009178	Walker B motif; other site
568206009179	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
568206009180	YjzC-like protein; Region: YjzC; pfam14168
568206009181	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206009182	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206009183	active site
568206009184	motif I; other site
568206009185	motif II; other site
568206009186	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
568206009187	Protein of unknown function (DUF3813); Region: DUF3813; pfam12758
568206009188	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206009189	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206009190	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206009191	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206009192	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
568206009193	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
568206009194	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
568206009195	S1 domain; Region: S1_2; pfam13509
568206009196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
568206009197	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
568206009198	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206009199	non-specific DNA binding site [nucleotide binding]; other site
568206009200	salt bridge; other site
568206009201	sequence-specific DNA binding site [nucleotide binding]; other site
568206009202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
568206009203	binding surface
568206009204	TPR motif; other site
568206009205	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206009206	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
568206009207	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
568206009208	active site
568206009209	catalytic site [active]
568206009210	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
568206009211	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
568206009212	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
568206009213	tetramer interface [polypeptide binding]; other site
568206009214	heme binding pocket [chemical binding]; other site
568206009215	ferrochelatase; Provisional; Region: PRK12435
568206009216	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
568206009217	C-terminal domain interface [polypeptide binding]; other site
568206009218	active site
568206009219	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
568206009220	active site
568206009221	N-terminal domain interface [polypeptide binding]; other site
568206009222	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
568206009223	active site
568206009224	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
568206009225	dimer interface [polypeptide binding]; other site
568206009226	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
568206009227	Ligand Binding Site [chemical binding]; other site
568206009228	Molecular Tunnel; other site
568206009229	Protein of unknown function (DUF2777); Region: DUF2777; pfam10949
568206009230	hypothetical protein; Provisional; Region: PRK13673
568206009231	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
568206009232	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206009233	inhibitor-cofactor binding pocket; inhibition site
568206009234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206009235	catalytic residue [active]
568206009236	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
568206009237	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
568206009238	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
568206009239	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
568206009240	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
568206009241	Spore germination protein GerPC; Region: GerPC; pfam10737
568206009242	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
568206009243	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
568206009244	hypothetical protein; Provisional; Region: PRK07758
568206009245	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
568206009246	Part of AAA domain; Region: AAA_19; pfam13245
568206009247	Family description; Region: UvrD_C_2; pfam13538
568206009248	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
568206009249	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
568206009250	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
568206009251	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568206009252	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206009253	Catalytic site [active]
568206009254	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568206009255	Uncharacterized conserved protein [Function unknown]; Region: COG0398
568206009256	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568206009257	ComK protein; Region: ComK; pfam06338
568206009258	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568206009259	DNA-binding site [nucleotide binding]; DNA binding site
568206009260	RNA-binding motif; other site
568206009261	Phosphotransferase enzyme family; Region: APH; pfam01636
568206009262	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
568206009263	active site
568206009264	substrate binding site [chemical binding]; other site
568206009265	ATP binding site [chemical binding]; other site
568206009266	isocitrate lyase; Provisional; Region: PRK15063
568206009267	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
568206009268	tetramer interface [polypeptide binding]; other site
568206009269	active site
568206009270	Mg2+/Mn2+ binding site [ion binding]; other site
568206009271	malate synthase A; Region: malate_syn_A; TIGR01344
568206009272	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
568206009273	active site
568206009274	S-layer homology domain; Region: SLH; pfam00395
568206009275	S-layer homology domain; Region: SLH; pfam00395
568206009276	S-layer homology domain; Region: SLH; pfam00395
568206009277	S-layer homology domain; Region: SLH; pfam00395
568206009278	S-layer homology domain; Region: SLH; pfam00395
568206009279	S-layer homology domain; Region: SLH; pfam00395
568206009280	S-layer homology domain; Region: SLH; pfam00395
568206009281	S-layer homology domain; Region: SLH; pfam00395
568206009282	S-layer homology domain; Region: SLH; pfam00395
568206009283	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
568206009284	EamA-like transporter family; Region: EamA; pfam00892
568206009285	EamA-like transporter family; Region: EamA; pfam00892
568206009286	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
568206009287	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206009288	dimerization interface [polypeptide binding]; other site
568206009289	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206009290	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206009291	dimer interface [polypeptide binding]; other site
568206009292	putative CheW interface [polypeptide binding]; other site
568206009293	Peptidase family M48; Region: Peptidase_M48; pfam01435
568206009294	CAAX protease self-immunity; Region: Abi; pfam02517
568206009295	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206009296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206009297	active site
568206009298	phosphorylation site [posttranslational modification]
568206009299	intermolecular recognition site; other site
568206009300	dimerization interface [polypeptide binding]; other site
568206009301	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206009302	DNA binding site [nucleotide binding]
568206009303	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206009304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206009305	dimer interface [polypeptide binding]; other site
568206009306	phosphorylation site [posttranslational modification]
568206009307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206009308	ATP binding site [chemical binding]; other site
568206009309	Mg2+ binding site [ion binding]; other site
568206009310	G-X-G motif; other site
568206009311	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206009312	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
568206009313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206009314	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568206009315	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206009316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
568206009317	RNA polymerase sigma factor; Provisional; Region: PRK12541
568206009318	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206009319	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206009320	DNA binding residues [nucleotide binding]
568206009321	Putative zinc-finger; Region: zf-HC2; pfam13490
568206009322	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
568206009323	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
568206009324	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206009325	Zn2+ binding site [ion binding]; other site
568206009326	Mg2+ binding site [ion binding]; other site
568206009327	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
568206009328	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206009329	putative active site [active]
568206009330	putative metal binding site [ion binding]; other site
568206009331	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
568206009332	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
568206009333	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
568206009334	RHS protein; Region: RHS; pfam03527
568206009335	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
568206009336	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
568206009337	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
568206009338	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
568206009339	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
568206009340	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
568206009341	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
568206009342	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
568206009343	Aureocin-like type II bacteriocin; Region: Bacteriocin_IIi; pfam11758
568206009344	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206009345	heme-binding site [chemical binding]; other site
568206009346	S-layer homology domain; Region: SLH; pfam00395
568206009347	S-layer homology domain; Region: SLH; pfam00395
568206009348	S-layer homology domain; Region: SLH; pfam00395
568206009349	rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150
568206009350	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
568206009351	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
568206009352	acyl-activating enzyme (AAE) consensus motif; other site
568206009353	putative AMP binding site [chemical binding]; other site
568206009354	putative active site [active]
568206009355	putative CoA binding site [chemical binding]; other site
568206009356	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462
568206009357	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
568206009358	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
568206009359	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
568206009360	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
568206009361	YhfH-like protein; Region: YhfH; pfam14149
568206009362	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206009363	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206009364	DNA binding site [nucleotide binding]
568206009365	domain linker motif; other site
568206009366	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568206009367	putative dimerization interface [polypeptide binding]; other site
568206009368	putative ligand binding site [chemical binding]; other site
568206009369	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206009370	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206009371	Coenzyme A binding pocket [chemical binding]; other site
568206009372	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
568206009373	Predicted membrane protein [Function unknown]; Region: COG1511
568206009374	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568206009375	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
568206009376	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
568206009377	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
568206009378	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206009379	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206009380	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
568206009381	Penicillinase repressor; Region: Pencillinase_R; pfam03965
568206009382	Fn3 associated; Region: Fn3_assoc; pfam13287
568206009383	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
568206009384	generic binding surface II; other site
568206009385	generic binding surface I; other site
568206009386	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
568206009387	putative active site [active]
568206009388	putative catalytic site [active]
568206009389	putative Mg binding site IVb [ion binding]; other site
568206009390	putative phosphate binding site [ion binding]; other site
568206009391	putative DNA binding site [nucleotide binding]; other site
568206009392	putative Mg binding site IVa [ion binding]; other site
568206009393	Protein of unknown function (DUF4026); Region: DUF4026; pfam13218
568206009394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
568206009395	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
568206009396	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206009397	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206009398	ferrochelatase; Provisional; Region: PRK12435
568206009399	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
568206009400	C-terminal domain interface [polypeptide binding]; other site
568206009401	active site
568206009402	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
568206009403	active site
568206009404	N-terminal domain interface [polypeptide binding]; other site
568206009405	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
568206009406	substrate binding site [chemical binding]; other site
568206009407	active site
568206009408	Transglycosylase; Region: Transgly; pfam00912
568206009409	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568206009410	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206009411	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
568206009412	Bacterial PH domain; Region: DUF304; pfam03703
568206009413	Bacterial PH domain; Region: DUF304; pfam03703
568206009414	Bacterial PH domain; Region: DUF304; pfam03703
568206009415	Uncharacterized conserved protein [Function unknown]; Region: COG3402
568206009416	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
568206009417	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206009418	DNA binding residues [nucleotide binding]
568206009419	drug binding residues [chemical binding]; other site
568206009420	dimer interface [polypeptide binding]; other site
568206009421	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
568206009422	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
568206009423	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
568206009424	Predicted membrane protein [Function unknown]; Region: COG3428
568206009425	Bacterial PH domain; Region: DUF304; cl01348
568206009426	Bacterial PH domain; Region: DUF304; pfam03703
568206009427	Bacterial PH domain; Region: DUF304; pfam03703
568206009428	Uncharacterized conserved protein [Function unknown]; Region: COG3402
568206009429	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206009430	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206009431	EcsC protein family; Region: EcsC; pfam12787
568206009432	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
568206009433	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
568206009434	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206009435	Walker A/P-loop; other site
568206009436	ATP binding site [chemical binding]; other site
568206009437	Q-loop/lid; other site
568206009438	ABC transporter signature motif; other site
568206009439	Walker B; other site
568206009440	D-loop; other site
568206009441	H-loop/switch region; other site
568206009442	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
568206009443	HIT family signature motif; other site
568206009444	catalytic residue [active]
568206009445	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
568206009446	transcriptional regulator Hpr; Provisional; Region: PRK13777
568206009447	MarR family; Region: MarR; pfam01047
568206009448	Protein of unknown function (DUF1878); Region: DUF1878; pfam08963
568206009449	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
568206009450	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
568206009451	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
568206009452	Part of AAA domain; Region: AAA_19; pfam13245
568206009453	Family description; Region: UvrD_C_2; pfam13538
568206009454	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568206009455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009456	putative substrate translocation pore; other site
568206009457	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568206009458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009459	putative substrate translocation pore; other site
568206009460	DoxX-like family; Region: DoxX_2; pfam13564
568206009461	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206009462	MarR family; Region: MarR; pfam01047
568206009463	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
568206009464	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
568206009465	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206009466	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
568206009467	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206009468	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206009469	DNA binding residues [nucleotide binding]
568206009470	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
568206009471	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
568206009472	glycerol kinase; Provisional; Region: glpK; PRK00047
568206009473	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
568206009474	N- and C-terminal domain interface [polypeptide binding]; other site
568206009475	active site
568206009476	MgATP binding site [chemical binding]; other site
568206009477	catalytic site [active]
568206009478	metal binding site [ion binding]; metal-binding site
568206009479	glycerol binding site [chemical binding]; other site
568206009480	homotetramer interface [polypeptide binding]; other site
568206009481	homodimer interface [polypeptide binding]; other site
568206009482	FBP binding site [chemical binding]; other site
568206009483	protein IIAGlc interface [polypeptide binding]; other site
568206009484	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
568206009485	amphipathic channel; other site
568206009486	Asn-Pro-Ala signature motifs; other site
568206009487	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
568206009488	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206009489	non-specific DNA binding site [nucleotide binding]; other site
568206009490	salt bridge; other site
568206009491	sequence-specific DNA binding site [nucleotide binding]; other site
568206009492	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
568206009493	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
568206009494	Sporulation protein YhaL; Region: Spore_YhaL; pfam14147
568206009495	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206009496	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
568206009497	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206009498	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206009499	TPR motif; other site
568206009500	binding surface
568206009501	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568206009502	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206009503	Zn binding site [ion binding]; other site
568206009504	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568206009505	Zn binding site [ion binding]; other site
568206009506	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568206009507	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206009508	Zn binding site [ion binding]; other site
568206009509	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568206009510	Zn binding site [ion binding]; other site
568206009511	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568206009512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009513	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206009514	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206009515	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
568206009516	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
568206009517	generic binding surface II; other site
568206009518	generic binding surface I; other site
568206009519	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206009520	Zn2+ binding site [ion binding]; other site
568206009521	Mg2+ binding site [ion binding]; other site
568206009522	AAA domain; Region: AAA_27; pfam13514
568206009523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206009524	Q-loop/lid; other site
568206009525	ABC transporter signature motif; other site
568206009526	Walker B; other site
568206009527	D-loop; other site
568206009528	H-loop/switch region; other site
568206009529	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
568206009530	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
568206009531	Probable transposase; Region: OrfB_IS605; pfam01385
568206009532	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
568206009533	AAA domain; Region: AAA_27; pfam13514
568206009534	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
568206009535	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
568206009536	active site
568206009537	metal binding site [ion binding]; metal-binding site
568206009538	DNA binding site [nucleotide binding]
568206009539	YhzD-like protein; Region: YhzD; pfam14120
568206009540	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
568206009541	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
568206009542	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568206009543	NADP binding site [chemical binding]; other site
568206009544	dimer interface [polypeptide binding]; other site
568206009545	hypothetical protein; Provisional; Region: PRK12856
568206009546	Protein of unknown function (DUF4028); Region: DUF4028; pfam13220
568206009547	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
568206009548	CHASE3 domain; Region: CHASE3; pfam05227
568206009549	GAF domain; Region: GAF; pfam01590
568206009550	GAF domain; Region: GAF_2; pfam13185
568206009551	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206009552	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206009553	dimer interface [polypeptide binding]; other site
568206009554	phosphorylation site [posttranslational modification]
568206009555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206009556	ATP binding site [chemical binding]; other site
568206009557	Mg2+ binding site [ion binding]; other site
568206009558	G-X-G motif; other site
568206009559	Response regulator receiver domain; Region: Response_reg; pfam00072
568206009560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206009561	active site
568206009562	phosphorylation site [posttranslational modification]
568206009563	intermolecular recognition site; other site
568206009564	dimerization interface [polypeptide binding]; other site
568206009565	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
568206009566	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
568206009567	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
568206009568	Response regulator receiver domain; Region: Response_reg; pfam00072
568206009569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206009570	active site
568206009571	phosphorylation site [posttranslational modification]
568206009572	intermolecular recognition site; other site
568206009573	dimerization interface [polypeptide binding]; other site
568206009574	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
568206009575	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
568206009576	Ferritin-like domain; Region: Ferritin; pfam00210
568206009577	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
568206009578	dinuclear metal binding motif [ion binding]; other site
568206009579	RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941
568206009580	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206009581	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
568206009582	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206009583	DNA binding residues [nucleotide binding]
568206009584	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
568206009585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206009586	ATP binding site [chemical binding]; other site
568206009587	Mg2+ binding site [ion binding]; other site
568206009588	G-X-G motif; other site
568206009589	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
568206009590	anti sigma factor interaction site; other site
568206009591	regulatory phosphorylation site [posttranslational modification]; other site
568206009592	Predicted membrane protein [Function unknown]; Region: COG2261
568206009593	CsbD-like; Region: CsbD; pfam05532
568206009594	Heat induced stress protein YflT; Region: YflT; pfam11181
568206009595	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
568206009596	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206009597	Transcriptional regulator PadR-like family; Region: PadR; cl17335
568206009598	S-layer homology domain; Region: SLH; pfam00395
568206009599	S-layer homology domain; Region: SLH; pfam00395
568206009600	S-layer homology domain; Region: SLH; pfam00395
568206009601	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
568206009602	potential frameshift: common BLAST hit: gi|225862925|ref|YP_002748303.1| HD domain protein
568206009603	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
568206009604	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206009605	Zn2+ binding site [ion binding]; other site
568206009606	Mg2+ binding site [ion binding]; other site
568206009607	CAAX protease self-immunity; Region: Abi; pfam02517
568206009608	Predicted transcriptional regulator [Transcription]; Region: COG1959
568206009609	Transcriptional regulator; Region: Rrf2; pfam02082
568206009610	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
568206009611	dihydroxyacetone kinase; Provisional; Region: PRK14479
568206009612	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
568206009613	DAK2 domain; Region: Dak2; pfam02734
568206009614	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
568206009615	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
568206009616	DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483
568206009617	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
568206009618	VanZ like family; Region: VanZ; pfam04892
568206009619	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
568206009620	ATP synthase I chain; Region: ATP_synt_I; pfam03899
568206009621	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
568206009622	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
568206009623	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568206009624	MarR family; Region: MarR_2; pfam12802
568206009625	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
568206009626	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
568206009627	YmzC-like protein; Region: YmzC; pfam14157
568206009628	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206009629	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206009630	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
568206009631	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
568206009632	putative NAD(P) binding site [chemical binding]; other site
568206009633	active site
568206009634	putative substrate binding site [chemical binding]; other site
568206009635	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206009636	HPP family; Region: HPP; pfam04982
568206009637	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
568206009638	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
568206009639	CGNR zinc finger; Region: zf-CGNR; pfam11706
568206009640	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
568206009641	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
568206009642	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206009643	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568206009644	Predicted permeases [General function prediction only]; Region: COG0701
568206009645	Predicted permease; Region: DUF318; cl17795
568206009646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009647	putative substrate translocation pore; other site
568206009648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009649	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206009650	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206009651	hypothetical protein; Provisional; Region: PRK10621
568206009652	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
568206009653	Predicted transcriptional regulators [Transcription]; Region: COG1378
568206009654	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
568206009655	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
568206009656	C-terminal domain interface [polypeptide binding]; other site
568206009657	sugar binding site [chemical binding]; other site
568206009658	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
568206009659	replicative DNA helicase; Provisional; Region: PRK06749
568206009660	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
568206009661	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
568206009662	Walker A motif; other site
568206009663	ATP binding site [chemical binding]; other site
568206009664	Walker B motif; other site
568206009665	DNA binding loops [nucleotide binding]
568206009666	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
568206009667	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
568206009668	DNA binding residues [nucleotide binding]
568206009669	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568206009670	dimer interface [polypeptide binding]; other site
568206009671	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
568206009672	Tic20-like protein; Region: Tic20; pfam09685
568206009673	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
568206009674	Protein of unknown function (DUF524); Region: DUF524; pfam04411
568206009675	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
568206009676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
568206009677	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
568206009678	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
568206009679	putative metal binding site [ion binding]; other site
568206009680	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
568206009681	putative metal binding site [ion binding]; other site
568206009682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
568206009683	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
568206009684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206009685	active site
568206009686	phosphorylation site [posttranslational modification]
568206009687	intermolecular recognition site; other site
568206009688	dimerization interface [polypeptide binding]; other site
568206009689	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
568206009690	PAS domain; Region: PAS; smart00091
568206009691	putative active site [active]
568206009692	heme pocket [chemical binding]; other site
568206009693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206009694	ATP binding site [chemical binding]; other site
568206009695	Mg2+ binding site [ion binding]; other site
568206009696	G-X-G motif; other site
568206009697	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
568206009698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009699	putative substrate translocation pore; other site
568206009700	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
568206009701	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
568206009702	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
568206009703	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
568206009704	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206009705	Walker A/P-loop; other site
568206009706	ATP binding site [chemical binding]; other site
568206009707	Q-loop/lid; other site
568206009708	ABC transporter signature motif; other site
568206009709	Walker B; other site
568206009710	D-loop; other site
568206009711	H-loop/switch region; other site
568206009712	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
568206009713	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568206009714	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206009715	Walker B; other site
568206009716	D-loop; other site
568206009717	H-loop/switch region; other site
568206009718	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
568206009719	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568206009720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206009721	Walker A/P-loop; other site
568206009722	ATP binding site [chemical binding]; other site
568206009723	Q-loop/lid; other site
568206009724	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568206009725	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
568206009726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206009727	dimer interface [polypeptide binding]; other site
568206009728	conserved gate region; other site
568206009729	putative PBP binding loops; other site
568206009730	ABC-ATPase subunit interface; other site
568206009731	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206009732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206009733	dimer interface [polypeptide binding]; other site
568206009734	conserved gate region; other site
568206009735	putative PBP binding loops; other site
568206009736	ABC-ATPase subunit interface; other site
568206009737	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
568206009738	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
568206009739	Yip1 domain; Region: Yip1; pfam04893
568206009740	ornithine cyclodeaminase; Validated; Region: PRK08618
568206009741	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
568206009742	NAD(P) binding site [chemical binding]; other site
568206009743	proline racemase; Provisional; Region: PRK13969
568206009744	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
568206009745	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
568206009746	Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041
568206009747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206009748	S-adenosylmethionine binding site [chemical binding]; other site
568206009749	S-layer homology domain; Region: SLH; pfam00395
568206009750	S-layer homology domain; Region: SLH; pfam00395
568206009751	S-layer homology domain; Region: SLH; pfam00395
568206009752	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
568206009753	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568206009754	active site
568206009755	metal binding site [ion binding]; metal-binding site
568206009756	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568206009757	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
568206009758	putative oligomer interface [polypeptide binding]; other site
568206009759	putative active site [active]
568206009760	metal binding site [ion binding]; metal-binding site
568206009761	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
568206009762	metal binding site [ion binding]; metal-binding site
568206009763	enoyl-CoA hydratase; Provisional; Region: PRK07659
568206009764	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
568206009765	substrate binding site [chemical binding]; other site
568206009766	oxyanion hole (OAH) forming residues; other site
568206009767	trimer interface [polypeptide binding]; other site
568206009768	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
568206009769	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
568206009770	DHHW protein; Region: DHHW; pfam14286
568206009771	DHHW protein; Region: DHHW; pfam14286
568206009772	S-layer homology domain; Region: SLH; pfam00395
568206009773	S-layer homology domain; Region: SLH; pfam00395
568206009774	S-layer homology domain; Region: SLH; pfam00395
568206009775	S-layer homology domain; Region: SLH; pfam00395
568206009776	S-layer homology domain; Region: SLH; pfam00395
568206009777	S-layer homology domain; Region: SLH; pfam00395
568206009778	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
568206009779	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
568206009780	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
568206009781	stage V sporulation protein B; Region: spore_V_B; TIGR02900
568206009782	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568206009783	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
568206009784	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
568206009785	ATP binding site [chemical binding]; other site
568206009786	putative Mg++ binding site [ion binding]; other site
568206009787	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
568206009788	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206009789	nucleotide binding region [chemical binding]; other site
568206009790	ATP-binding site [chemical binding]; other site
568206009791	high affinity sulphate transporter 1; Region: sulP; TIGR00815
568206009792	Sulfate transporter family; Region: Sulfate_transp; pfam00916
568206009793	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
568206009794	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
568206009795	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206009796	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
568206009797	acyl-activating enzyme (AAE) consensus motif; other site
568206009798	acyl-activating enzyme (AAE) consensus motif; other site
568206009799	putative AMP binding site [chemical binding]; other site
568206009800	putative active site [active]
568206009801	putative CoA binding site [chemical binding]; other site
568206009802	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
568206009803	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
568206009804	amidase catalytic site [active]
568206009805	Zn binding residues [ion binding]; other site
568206009806	substrate binding site [chemical binding]; other site
568206009807	S-layer homology domain; Region: SLH; pfam00395
568206009808	S-layer homology domain; Region: SLH; pfam00395
568206009809	S-layer homology domain; Region: SLH; pfam00395
568206009810	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
568206009811	Cna protein B-type domain; Region: Cna_B; pfam05738
568206009812	Cna protein B-type domain; Region: Cna_B; pfam05738
568206009813	Cna protein B-type domain; Region: Cna_B; pfam05738
568206009814	Cna protein B-type domain; Region: Cna_B; pfam05738
568206009815	Cna protein B-type domain; Region: Cna_B; pfam05738
568206009816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
568206009817	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206009818	active site
568206009819	motif I; other site
568206009820	motif II; other site
568206009821	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206009822	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
568206009823	active site
568206009824	DNA binding site [nucleotide binding]
568206009825	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
568206009826	acetolactate synthase; Reviewed; Region: PRK08617
568206009827	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568206009828	PYR/PP interface [polypeptide binding]; other site
568206009829	dimer interface [polypeptide binding]; other site
568206009830	TPP binding site [chemical binding]; other site
568206009831	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568206009832	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
568206009833	TPP-binding site [chemical binding]; other site
568206009834	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
568206009835	hypothetical protein; Provisional; Region: PRK13676
568206009836	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
568206009837	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
568206009838	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
568206009839	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
568206009840	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568206009841	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
568206009842	Walker A/P-loop; other site
568206009843	ATP binding site [chemical binding]; other site
568206009844	Q-loop/lid; other site
568206009845	ABC transporter signature motif; other site
568206009846	Walker B; other site
568206009847	D-loop; other site
568206009848	H-loop/switch region; other site
568206009849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206009850	dimer interface [polypeptide binding]; other site
568206009851	conserved gate region; other site
568206009852	putative PBP binding loops; other site
568206009853	ABC-ATPase subunit interface; other site
568206009854	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568206009855	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568206009856	substrate binding pocket [chemical binding]; other site
568206009857	membrane-bound complex binding site; other site
568206009858	hinge residues; other site
568206009859	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
568206009860	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568206009861	Walker A/P-loop; other site
568206009862	ATP binding site [chemical binding]; other site
568206009863	Q-loop/lid; other site
568206009864	ABC transporter signature motif; other site
568206009865	Walker B; other site
568206009866	D-loop; other site
568206009867	H-loop/switch region; other site
568206009868	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568206009869	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206009870	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206009871	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
568206009872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206009873	Walker A/P-loop; other site
568206009874	ATP binding site [chemical binding]; other site
568206009875	Q-loop/lid; other site
568206009876	ABC transporter signature motif; other site
568206009877	Walker B; other site
568206009878	D-loop; other site
568206009879	H-loop/switch region; other site
568206009880	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
568206009881	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
568206009882	tetrameric interface [polypeptide binding]; other site
568206009883	activator binding site; other site
568206009884	NADP binding site [chemical binding]; other site
568206009885	substrate binding site [chemical binding]; other site
568206009886	catalytic residues [active]
568206009887	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
568206009888	glutamate racemase; Provisional; Region: PRK00865
568206009889	arginine:agmatin antiporter; Provisional; Region: PRK10644
568206009890	Spore germination protein; Region: Spore_permease; cl17796
568206009891	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
568206009892	hydroperoxidase II; Provisional; Region: katE; PRK11249
568206009893	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
568206009894	tetramer interface [polypeptide binding]; other site
568206009895	heme binding pocket [chemical binding]; other site
568206009896	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
568206009897	domain interactions; other site
568206009898	intracellular protease, PfpI family; Region: PfpI; TIGR01382
568206009899	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
568206009900	proposed catalytic triad [active]
568206009901	conserved cys residue [active]
568206009902	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206009903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009904	putative substrate translocation pore; other site
568206009905	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
568206009906	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
568206009907	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
568206009908	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568206009909	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
568206009910	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
568206009911	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206009912	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206009913	putative DNA binding site [nucleotide binding]; other site
568206009914	putative Zn2+ binding site [ion binding]; other site
568206009915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009916	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206009917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206009918	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206009919	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206009920	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
568206009921	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
568206009922	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206009923	Coenzyme A binding pocket [chemical binding]; other site
568206009924	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
568206009925	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
568206009926	AsnC family; Region: AsnC_trans_reg; pfam01037
568206009927	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206009928	EamA-like transporter family; Region: EamA; pfam00892
568206009929	EamA-like transporter family; Region: EamA; pfam00892
568206009930	hypothetical protein; Provisional; Region: PRK06770
568206009931	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
568206009932	DoxX; Region: DoxX; pfam07681
568206009933	Uncharacterized conserved protein [Function unknown]; Region: COG3589
568206009934	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
568206009935	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568206009936	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
568206009937	active site turn [active]
568206009938	phosphorylation site [posttranslational modification]
568206009939	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568206009940	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
568206009941	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
568206009942	putative active site [active]
568206009943	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568206009944	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568206009945	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568206009946	putative active site [active]
568206009947	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
568206009948	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
568206009949	amino acid transporter; Region: 2A0306; TIGR00909
568206009950	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
568206009951	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206009952	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
568206009953	active site
568206009954	metal binding site [ion binding]; metal-binding site
568206009955	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
568206009956	Interdomain contacts; other site
568206009957	Cytokine receptor motif; other site
568206009958	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
568206009959	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
568206009960	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
568206009961	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568206009962	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568206009963	Uncharacterized conserved protein [Function unknown]; Region: COG3339
568206009964	yybP-ykoY leader
568206009965	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
568206009966	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
568206009967	putative DNA binding site [nucleotide binding]; other site
568206009968	putative homodimer interface [polypeptide binding]; other site
568206009969	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
568206009970	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
568206009971	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206009972	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206009973	active site
568206009974	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
568206009975	CotJB protein; Region: CotJB; pfam12652
568206009976	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
568206009977	dimanganese center [ion binding]; other site
568206009978	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
568206009979	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568206009980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206009981	dimer interface [polypeptide binding]; other site
568206009982	conserved gate region; other site
568206009983	ABC-ATPase subunit interface; other site
568206009984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
568206009985	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206009986	conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381
568206009987	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
568206009988	HlyD family secretion protein; Region: HlyD_3; pfam13437
568206009989	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206009990	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206009991	Walker A/P-loop; other site
568206009992	ATP binding site [chemical binding]; other site
568206009993	Q-loop/lid; other site
568206009994	ABC transporter signature motif; other site
568206009995	Walker B; other site
568206009996	D-loop; other site
568206009997	H-loop/switch region; other site
568206009998	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568206009999	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206010000	FtsX-like permease family; Region: FtsX; pfam02687
568206010001	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206010002	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206010003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
568206010004	Uncharacterized conserved protein [Function unknown]; Region: COG3589
568206010005	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
568206010006	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568206010007	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568206010008	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568206010009	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568206010010	active site
568206010011	methionine cluster; other site
568206010012	phosphorylation site [posttranslational modification]
568206010013	metal binding site [ion binding]; metal-binding site
568206010014	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568206010015	HTH domain; Region: HTH_11; pfam08279
568206010016	Mga helix-turn-helix domain; Region: Mga; pfam05043
568206010017	PRD domain; Region: PRD; pfam00874
568206010018	PRD domain; Region: PRD; pfam00874
568206010019	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568206010020	active site
568206010021	P-loop; other site
568206010022	phosphorylation site [posttranslational modification]
568206010023	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568206010024	active site
568206010025	phosphorylation site [posttranslational modification]
568206010026	Uncharacterized conserved protein [Function unknown]; Region: COG3589
568206010027	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
568206010028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206010029	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206010030	putative substrate translocation pore; other site
568206010031	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
568206010032	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
568206010033	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
568206010034	PhoU domain; Region: PhoU; pfam01895
568206010035	PhoU domain; Region: PhoU; pfam01895
568206010036	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
568206010037	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
568206010038	NADP binding site [chemical binding]; other site
568206010039	dimer interface [polypeptide binding]; other site
568206010040	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
568206010041	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
568206010042	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
568206010043	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568206010044	active site residue [active]
568206010045	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568206010046	active site residue [active]
568206010047	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
568206010048	CPxP  motif; other site
568206010049	Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523
568206010050	active site residue [active]
568206010051	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206010052	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
568206010053	CPxP  motif; other site
568206010054	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568206010055	active site residue [active]
568206010056	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
568206010057	putative homodimer interface [polypeptide binding]; other site
568206010058	putative homotetramer interface [polypeptide binding]; other site
568206010059	putative metal binding site [ion binding]; other site
568206010060	putative homodimer-homodimer interface [polypeptide binding]; other site
568206010061	putative allosteric switch controlling residues; other site
568206010062	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
568206010063	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206010064	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568206010065	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
568206010066	active site residue [active]
568206010067	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
568206010068	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
568206010069	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206010070	putative DNA binding site [nucleotide binding]; other site
568206010071	putative Zn2+ binding site [ion binding]; other site
568206010072	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206010073	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
568206010074	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
568206010075	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
568206010076	SpoVR like protein; Region: SpoVR; pfam04293
568206010077	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
568206010078	putative FMN binding site [chemical binding]; other site
568206010079	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
568206010080	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
568206010081	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
568206010082	potential frameshift: common BLAST hit: gi|218901950|ref|YP_002449784.1| spore germination protein GerYB
568206010083	Spore germination protein; Region: Spore_permease; cl17796
568206010084	Spore germination protein; Region: Spore_permease; cl17796
568206010085	Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798
568206010086	YhdB-like protein; Region: YhdB; pfam14148
568206010087	putative disulfide oxidoreductase; Provisional; Region: PRK03113
568206010088	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568206010089	catalytic residues [active]
568206010090	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
568206010091	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206010092	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206010093	DNA binding site [nucleotide binding]
568206010094	domain linker motif; other site
568206010095	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
568206010096	dimerization interface [polypeptide binding]; other site
568206010097	ligand binding site [chemical binding]; other site
568206010098	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
568206010099	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568206010100	active site turn [active]
568206010101	phosphorylation site [posttranslational modification]
568206010102	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568206010103	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
568206010104	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
568206010105	substrate binding [chemical binding]; other site
568206010106	active site
568206010107	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
568206010108	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
568206010109	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
568206010110	putative substrate binding site [chemical binding]; other site
568206010111	putative ATP binding site [chemical binding]; other site
568206010112	potential frameshift: common BLAST hit: gi|49480296|ref|YP_035009.1| ErfK/YbiS/YcfS/YnhG family protein
568206010113	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
568206010114	short chain dehydrogenase; Provisional; Region: PRK06701
568206010115	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
568206010116	NAD binding site [chemical binding]; other site
568206010117	metal binding site [ion binding]; metal-binding site
568206010118	active site
568206010119	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
568206010120	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
568206010121	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
568206010122	active site
568206010123	nucleophile elbow; other site
568206010124	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206010125	MarR family; Region: MarR; pfam01047
568206010126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206010127	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206010128	putative substrate translocation pore; other site
568206010129	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
568206010130	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
568206010131	Ligand Binding Site [chemical binding]; other site
568206010132	potassium-transporting ATPase subunit C; Provisional; Region: PRK13997
568206010133	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
568206010134	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568206010135	Soluble P-type ATPase [General function prediction only]; Region: COG4087
568206010136	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
568206010137	ydaO/yuaA leader
568206010138	ydaO/yuaA leader
568206010139	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
568206010140	dimer interface [polypeptide binding]; other site
568206010141	substrate binding site [chemical binding]; other site
568206010142	ATP binding site [chemical binding]; other site
568206010143	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
568206010144	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
568206010145	ATP binding site [chemical binding]; other site
568206010146	substrate interface [chemical binding]; other site
568206010147	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
568206010148	ThiS interaction site; other site
568206010149	putative active site [active]
568206010150	tetramer interface [polypeptide binding]; other site
568206010151	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
568206010152	thiS-thiF/thiG interaction site; other site
568206010153	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
568206010154	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
568206010155	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
568206010156	thiamine phosphate binding site [chemical binding]; other site
568206010157	active site
568206010158	pyrophosphate binding site [ion binding]; other site
568206010159	NMT1/THI5 like; Region: NMT1; pfam09084
568206010160	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
568206010161	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
568206010162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010163	dimer interface [polypeptide binding]; other site
568206010164	conserved gate region; other site
568206010165	putative PBP binding loops; other site
568206010166	ABC-ATPase subunit interface; other site
568206010167	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
568206010168	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
568206010169	Walker A/P-loop; other site
568206010170	ATP binding site [chemical binding]; other site
568206010171	Q-loop/lid; other site
568206010172	ABC transporter signature motif; other site
568206010173	Walker B; other site
568206010174	D-loop; other site
568206010175	H-loop/switch region; other site
568206010176	Putative transcription activator [Transcription]; Region: TenA; COG0819
568206010177	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206010178	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206010179	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206010180	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206010181	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206010182	Domain of unknown function (DUF3960); Region: DUF3960; pfam13142
568206010183	Protein of unknown function (DUF3965); Region: DUF3965; pfam13112
568206010184	FOG: CBS domain [General function prediction only]; Region: COG0517
568206010185	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
568206010186	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
568206010187	AAA domain; Region: AAA_33; pfam13671
568206010188	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
568206010189	active site
568206010190	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
568206010191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010192	dimer interface [polypeptide binding]; other site
568206010193	conserved gate region; other site
568206010194	putative PBP binding loops; other site
568206010195	ABC-ATPase subunit interface; other site
568206010196	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
568206010197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010198	dimer interface [polypeptide binding]; other site
568206010199	conserved gate region; other site
568206010200	putative PBP binding loops; other site
568206010201	ABC-ATPase subunit interface; other site
568206010202	PBP superfamily domain; Region: PBP_like_2; cl17296
568206010203	PBP superfamily domain; Region: PBP_like_2; cl17296
568206010204	FeoA domain; Region: FeoA; pfam04023
568206010205	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
568206010206	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
568206010207	G1 box; other site
568206010208	GTP/Mg2+ binding site [chemical binding]; other site
568206010209	Switch I region; other site
568206010210	G2 box; other site
568206010211	G3 box; other site
568206010212	Switch II region; other site
568206010213	G4 box; other site
568206010214	G5 box; other site
568206010215	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
568206010216	Nucleoside recognition; Region: Gate; pfam07670
568206010217	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
568206010218	Nucleoside recognition; Region: Gate; pfam07670
568206010219	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
568206010220	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
568206010221	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
568206010222	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
568206010223	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
568206010224	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
568206010225	Na binding site [ion binding]; other site
568206010226	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
568206010227	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568206010228	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
568206010229	metal binding site [ion binding]; metal-binding site
568206010230	dimer interface [polypeptide binding]; other site
568206010231	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
568206010232	putative active site [active]
568206010233	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
568206010234	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
568206010235	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
568206010236	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
568206010237	D-pathway; other site
568206010238	Putative ubiquinol binding site [chemical binding]; other site
568206010239	Low-spin heme (heme b) binding site [chemical binding]; other site
568206010240	Putative water exit pathway; other site
568206010241	Binuclear center (heme o3/CuB) [ion binding]; other site
568206010242	K-pathway; other site
568206010243	Putative proton exit pathway; other site
568206010244	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
568206010245	Subunit I/III interface [polypeptide binding]; other site
568206010246	Subunit III/IV interface [polypeptide binding]; other site
568206010247	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
568206010248	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
568206010249	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
568206010250	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
568206010251	TrkA-N domain; Region: TrkA_N; pfam02254
568206010252	TrkA-C domain; Region: TrkA_C; pfam02080
568206010253	Protein of unknown function (DUF4022); Region: DUF4022; pfam13214
568206010254	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206010255	Coenzyme A binding pocket [chemical binding]; other site
568206010256	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206010257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206010258	non-specific DNA binding site [nucleotide binding]; other site
568206010259	salt bridge; other site
568206010260	sequence-specific DNA binding site [nucleotide binding]; other site
568206010261	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
568206010262	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
568206010263	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
568206010264	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943
568206010265	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
568206010266	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
568206010267	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
568206010268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206010269	putative substrate translocation pore; other site
568206010270	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
568206010271	active site
568206010272	catalytic site [active]
568206010273	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206010274	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206010275	non-specific DNA binding site [nucleotide binding]; other site
568206010276	salt bridge; other site
568206010277	sequence-specific DNA binding site [nucleotide binding]; other site
568206010278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
568206010279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
568206010280	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206010281	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206010282	dimer interface [polypeptide binding]; other site
568206010283	putative CheW interface [polypeptide binding]; other site
568206010284	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
568206010285	VanZ like family; Region: VanZ; pfam04892
568206010286	RDD family; Region: RDD; pfam06271
568206010287	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
568206010288	FAD binding domain; Region: FAD_binding_4; pfam01565
568206010289	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
568206010290	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
568206010291	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
568206010292	dimer interface [polypeptide binding]; other site
568206010293	active site
568206010294	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568206010295	substrate binding site [chemical binding]; other site
568206010296	catalytic residue [active]
568206010297	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
568206010298	putative catalytic site [active]
568206010299	metal binding site A [ion binding]; metal-binding site
568206010300	phosphate binding site [ion binding]; other site
568206010301	metal binding site C [ion binding]; metal-binding site
568206010302	metal binding site B [ion binding]; metal-binding site
568206010303	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
568206010304	Zn binding site [ion binding]; other site
568206010305	Ion channel; Region: Ion_trans_2; pfam07885
568206010306	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568206010307	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
568206010308	putative NAD(P) binding site [chemical binding]; other site
568206010309	catalytic Zn binding site [ion binding]; other site
568206010310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206010311	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206010312	putative substrate translocation pore; other site
568206010313	potential frameshift: common BLAST hit: gi|49183663|ref|YP_026915.1| immune inhibitor A metalloprotease
568206010314	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
568206010315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
568206010316	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
568206010317	active site
568206010318	intersubunit interactions; other site
568206010319	catalytic residue [active]
568206010320	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
568206010321	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
568206010322	ligand binding site [chemical binding]; other site
568206010323	dimerization interface [polypeptide binding]; other site
568206010324	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
568206010325	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
568206010326	TM-ABC transporter signature motif; other site
568206010327	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
568206010328	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
568206010329	Walker A/P-loop; other site
568206010330	ATP binding site [chemical binding]; other site
568206010331	Q-loop/lid; other site
568206010332	ABC transporter signature motif; other site
568206010333	Walker B; other site
568206010334	D-loop; other site
568206010335	H-loop/switch region; other site
568206010336	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
568206010337	D-ribose pyranase; Provisional; Region: PRK11797
568206010338	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
568206010339	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
568206010340	substrate binding site [chemical binding]; other site
568206010341	dimer interface [polypeptide binding]; other site
568206010342	ATP binding site [chemical binding]; other site
568206010343	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206010344	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206010345	DNA binding site [nucleotide binding]
568206010346	domain linker motif; other site
568206010347	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
568206010348	dimerization interface [polypeptide binding]; other site
568206010349	ligand binding site [chemical binding]; other site
568206010350	sodium binding site [ion binding]; other site
568206010351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206010352	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206010353	putative substrate translocation pore; other site
568206010354	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206010355	MarR family; Region: MarR; pfam01047
568206010356	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
568206010357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206010358	putative substrate translocation pore; other site
568206010359	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568206010360	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206010361	Walker A/P-loop; other site
568206010362	ATP binding site [chemical binding]; other site
568206010363	Q-loop/lid; other site
568206010364	ABC transporter signature motif; other site
568206010365	Walker B; other site
568206010366	D-loop; other site
568206010367	H-loop/switch region; other site
568206010368	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568206010369	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
568206010370	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206010371	Walker A/P-loop; other site
568206010372	ATP binding site [chemical binding]; other site
568206010373	Q-loop/lid; other site
568206010374	ABC transporter signature motif; other site
568206010375	Walker B; other site
568206010376	D-loop; other site
568206010377	H-loop/switch region; other site
568206010378	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
568206010379	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206010380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010381	putative PBP binding loops; other site
568206010382	ABC-ATPase subunit interface; other site
568206010383	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
568206010384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010385	dimer interface [polypeptide binding]; other site
568206010386	conserved gate region; other site
568206010387	putative PBP binding loops; other site
568206010388	ABC-ATPase subunit interface; other site
568206010389	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
568206010390	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
568206010391	peptide binding site [polypeptide binding]; other site
568206010392	Protein of unknown function (DUF4027); Region: DUF4027; pfam13219
568206010393	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
568206010394	Ligand Binding Site [chemical binding]; other site
568206010395	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
568206010396	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
568206010397	Sulfate transporter family; Region: Sulfate_transp; pfam00916
568206010398	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
568206010399	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
568206010400	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206010401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206010402	active site
568206010403	phosphorylation site [posttranslational modification]
568206010404	intermolecular recognition site; other site
568206010405	dimerization interface [polypeptide binding]; other site
568206010406	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206010407	DNA binding site [nucleotide binding]
568206010408	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206010409	dimerization interface [polypeptide binding]; other site
568206010410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206010411	dimer interface [polypeptide binding]; other site
568206010412	phosphorylation site [posttranslational modification]
568206010413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206010414	ATP binding site [chemical binding]; other site
568206010415	Mg2+ binding site [ion binding]; other site
568206010416	G-X-G motif; other site
568206010417	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
568206010418	RibD C-terminal domain; Region: RibD_C; cl17279
568206010419	Predicted transcriptional regulator [Transcription]; Region: COG2378
568206010420	HTH domain; Region: HTH_11; pfam08279
568206010421	WYL domain; Region: WYL; pfam13280
568206010422	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
568206010423	RNA polymerase sigma factor; Provisional; Region: PRK12542
568206010424	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206010425	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206010426	DNA binding residues [nucleotide binding]
568206010427	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
568206010428	nucleotide binding site/active site [active]
568206010429	HIT family signature motif; other site
568206010430	catalytic residue [active]
568206010431	OsmC-like protein; Region: OsmC; pfam02566
568206010432	S-methylmethionine transporter; Provisional; Region: PRK11387
568206010433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010434	dimer interface [polypeptide binding]; other site
568206010435	conserved gate region; other site
568206010436	putative PBP binding loops; other site
568206010437	ABC-ATPase subunit interface; other site
568206010438	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568206010439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010440	dimer interface [polypeptide binding]; other site
568206010441	conserved gate region; other site
568206010442	putative PBP binding loops; other site
568206010443	ABC-ATPase subunit interface; other site
568206010444	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568206010445	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568206010446	substrate binding pocket [chemical binding]; other site
568206010447	membrane-bound complex binding site; other site
568206010448	hinge residues; other site
568206010449	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568206010450	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
568206010451	Walker A/P-loop; other site
568206010452	ATP binding site [chemical binding]; other site
568206010453	Q-loop/lid; other site
568206010454	ABC transporter signature motif; other site
568206010455	Walker B; other site
568206010456	D-loop; other site
568206010457	H-loop/switch region; other site
568206010458	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
568206010459	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
568206010460	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
568206010461	active site
568206010462	ATP binding site [chemical binding]; other site
568206010463	substrate binding site [chemical binding]; other site
568206010464	CAAX protease self-immunity; Region: Abi; pfam02517
568206010465	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
568206010466	Spore germination protein; Region: Spore_permease; cl17796
568206010467	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
568206010468	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
568206010469	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568206010470	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
568206010471	Ca binding site [ion binding]; other site
568206010472	active site
568206010473	catalytic site [active]
568206010474	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
568206010475	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568206010476	active site turn [active]
568206010477	phosphorylation site [posttranslational modification]
568206010478	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568206010479	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206010480	DNA-binding site [nucleotide binding]; DNA binding site
568206010481	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
568206010482	UTRA domain; Region: UTRA; pfam07702
568206010483	Amino acid permease; Region: AA_permease_2; pfam13520
568206010484	Spore germination protein; Region: Spore_permease; cl17796
568206010485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206010486	PAS domain; Region: PAS_9; pfam13426
568206010487	putative active site [active]
568206010488	heme pocket [chemical binding]; other site
568206010489	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206010490	metal binding site [ion binding]; metal-binding site
568206010491	active site
568206010492	I-site; other site
568206010493	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568206010494	cardiolipin synthetase; Reviewed; Region: PRK12452
568206010495	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568206010496	putative active site [active]
568206010497	catalytic site [active]
568206010498	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568206010499	putative active site [active]
568206010500	catalytic site [active]
568206010501	MoxR-like ATPases [General function prediction only]; Region: COG0714
568206010502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206010503	Walker A motif; other site
568206010504	ATP binding site [chemical binding]; other site
568206010505	Walker B motif; other site
568206010506	arginine finger; other site
568206010507	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
568206010508	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
568206010509	metal ion-dependent adhesion site (MIDAS); other site
568206010510	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
568206010511	nudix motif; other site
568206010512	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568206010513	L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272
568206010514	NAD binding site [chemical binding]; other site
568206010515	homodimer interface [polypeptide binding]; other site
568206010516	active site
568206010517	putative substrate binding site [chemical binding]; other site
568206010518	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
568206010519	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
568206010520	substrate-cofactor binding pocket; other site
568206010521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206010522	catalytic residue [active]
568206010523	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568206010524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206010525	S-adenosylmethionine binding site [chemical binding]; other site
568206010526	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568206010527	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568206010528	Walker A/P-loop; other site
568206010529	ATP binding site [chemical binding]; other site
568206010530	Q-loop/lid; other site
568206010531	ABC transporter signature motif; other site
568206010532	Walker B; other site
568206010533	D-loop; other site
568206010534	H-loop/switch region; other site
568206010535	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
568206010536	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206010537	ABC-ATPase subunit  interface; other site
568206010538	dimer interface [polypeptide binding]; other site
568206010539	putative PBP binding regions; other site
568206010540	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206010541	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206010542	ABC-ATPase subunit  interface; other site
568206010543	dimer interface [polypeptide binding]; other site
568206010544	putative PBP binding regions; other site
568206010545	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
568206010546	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568206010547	siderophore binding site; other site
568206010548	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
568206010549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206010550	putative substrate translocation pore; other site
568206010551	acid-soluble spore protein H; Provisional; Region: sspH; PRK01625
568206010552	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206010553	dimerization interface [polypeptide binding]; other site
568206010554	putative Zn2+ binding site [ion binding]; other site
568206010555	putative DNA binding site [nucleotide binding]; other site
568206010556	L-lactate permease; Region: Lactate_perm; cl00701
568206010557	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
568206010558	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
568206010559	Aspartase; Region: Aspartase; cd01357
568206010560	active sites [active]
568206010561	tetramer interface [polypeptide binding]; other site
568206010562	Domain of unknown function DUF21; Region: DUF21; pfam01595
568206010563	FOG: CBS domain [General function prediction only]; Region: COG0517
568206010564	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568206010565	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
568206010566	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206010567	putative metal binding site [ion binding]; other site
568206010568	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
568206010569	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
568206010570	Nucleoside recognition; Region: Gate; pfam07670
568206010571	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
568206010572	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
568206010573	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
568206010574	VanW like protein; Region: VanW; pfam04294
568206010575	Uncharacterized conserved protein [Function unknown]; Region: COG0398
568206010576	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568206010577	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
568206010578	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
568206010579	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568206010580	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
568206010581	active site
568206010582	Zn binding site [ion binding]; other site
568206010583	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206010584	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206010585	non-specific DNA binding site [nucleotide binding]; other site
568206010586	salt bridge; other site
568206010587	sequence-specific DNA binding site [nucleotide binding]; other site
568206010588	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206010589	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
568206010590	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
568206010591	active site
568206010592	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
568206010593	metal-binding site [ion binding]
568206010594	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
568206010595	Heavy-metal-associated domain; Region: HMA; pfam00403
568206010596	metal-binding site [ion binding]
568206010597	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568206010598	Soluble P-type ATPase [General function prediction only]; Region: COG4087
568206010599	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206010600	dimerization interface [polypeptide binding]; other site
568206010601	putative DNA binding site [nucleotide binding]; other site
568206010602	putative Zn2+ binding site [ion binding]; other site
568206010603	amino acid transporter; Region: 2A0306; TIGR00909
568206010604	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
568206010605	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
568206010606	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
568206010607	hexamer interface [polypeptide binding]; other site
568206010608	ligand binding site [chemical binding]; other site
568206010609	putative active site [active]
568206010610	NAD(P) binding site [chemical binding]; other site
568206010611	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
568206010612	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
568206010613	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
568206010614	putative active site [active]
568206010615	catalytic site [active]
568206010616	putative metal binding site [ion binding]; other site
568206010617	Uncharacterized conserved protein [Function unknown]; Region: COG2427
568206010618	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
568206010619	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
568206010620	catalytic loop [active]
568206010621	iron binding site [ion binding]; other site
568206010622	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
568206010623	4Fe-4S binding domain; Region: Fer4; pfam00037
568206010624	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
568206010625	[4Fe-4S] binding site [ion binding]; other site
568206010626	molybdopterin cofactor binding site; other site
568206010627	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
568206010628	molybdopterin cofactor binding site; other site
568206010629	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
568206010630	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
568206010631	Arrestin_N terminal like; Region: LDB19; pfam13002
568206010632	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206010633	Coenzyme A binding pocket [chemical binding]; other site
568206010634	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206010635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206010636	active site
568206010637	phosphorylation site [posttranslational modification]
568206010638	intermolecular recognition site; other site
568206010639	dimerization interface [polypeptide binding]; other site
568206010640	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206010641	DNA binding site [nucleotide binding]
568206010642	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206010643	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206010644	dimerization interface [polypeptide binding]; other site
568206010645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206010646	dimer interface [polypeptide binding]; other site
568206010647	phosphorylation site [posttranslational modification]
568206010648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206010649	ATP binding site [chemical binding]; other site
568206010650	Mg2+ binding site [ion binding]; other site
568206010651	G-X-G motif; other site
568206010652	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
568206010653	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206010654	Coenzyme A binding pocket [chemical binding]; other site
568206010655	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568206010656	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206010657	DNA-binding site [nucleotide binding]; DNA binding site
568206010658	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206010659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206010660	homodimer interface [polypeptide binding]; other site
568206010661	catalytic residue [active]
568206010662	EamA-like transporter family; Region: EamA; pfam00892
568206010663	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
568206010664	EamA-like transporter family; Region: EamA; pfam00892
568206010665	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
568206010666	Malic enzyme, N-terminal domain; Region: malic; pfam00390
568206010667	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
568206010668	putative NAD(P) binding site [chemical binding]; other site
568206010669	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
568206010670	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
568206010671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206010672	active site
568206010673	phosphorylation site [posttranslational modification]
568206010674	intermolecular recognition site; other site
568206010675	dimerization interface [polypeptide binding]; other site
568206010676	sensory histidine kinase DcuS; Provisional; Region: PRK11086
568206010677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206010678	ATP binding site [chemical binding]; other site
568206010679	Mg2+ binding site [ion binding]; other site
568206010680	G-X-G motif; other site
568206010681	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
568206010682	Cache domain; Region: Cache_1; pfam02743
568206010683	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206010684	dimerization interface [polypeptide binding]; other site
568206010685	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206010686	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206010687	dimer interface [polypeptide binding]; other site
568206010688	putative CheW interface [polypeptide binding]; other site
568206010689	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
568206010690	putative active site [active]
568206010691	leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300
568206010692	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206010693	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206010694	dimer interface [polypeptide binding]; other site
568206010695	phosphorylation site [posttranslational modification]
568206010696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206010697	ATP binding site [chemical binding]; other site
568206010698	Mg2+ binding site [ion binding]; other site
568206010699	G-X-G motif; other site
568206010700	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206010701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206010702	active site
568206010703	phosphorylation site [posttranslational modification]
568206010704	intermolecular recognition site; other site
568206010705	dimerization interface [polypeptide binding]; other site
568206010706	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206010707	DNA binding site [nucleotide binding]
568206010708	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568206010709	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
568206010710	active site
568206010711	metal binding site [ion binding]; metal-binding site
568206010712	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568206010713	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
568206010714	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568206010715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
568206010716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010717	dimer interface [polypeptide binding]; other site
568206010718	conserved gate region; other site
568206010719	putative PBP binding loops; other site
568206010720	ABC-ATPase subunit interface; other site
568206010721	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
568206010722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206010723	dimer interface [polypeptide binding]; other site
568206010724	conserved gate region; other site
568206010725	putative PBP binding loops; other site
568206010726	ABC-ATPase subunit interface; other site
568206010727	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
568206010728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206010729	Walker A/P-loop; other site
568206010730	ATP binding site [chemical binding]; other site
568206010731	Q-loop/lid; other site
568206010732	ABC transporter signature motif; other site
568206010733	Walker B; other site
568206010734	D-loop; other site
568206010735	H-loop/switch region; other site
568206010736	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
568206010737	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
568206010738	Ankyrin repeat; Region: Ank; pfam00023
568206010739	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
568206010740	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
568206010741	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
568206010742	NosL; Region: NosL; cl01769
568206010743	hypothetical protein; Provisional; Region: PRK12784
568206010744	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
568206010745	Citrate transporter; Region: CitMHS; pfam03600
568206010746	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
568206010747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206010748	active site
568206010749	phosphorylation site [posttranslational modification]
568206010750	intermolecular recognition site; other site
568206010751	dimerization interface [polypeptide binding]; other site
568206010752	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
568206010753	PAS domain; Region: PAS; smart00091
568206010754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206010755	ATP binding site [chemical binding]; other site
568206010756	Mg2+ binding site [ion binding]; other site
568206010757	G-X-G motif; other site
568206010758	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
568206010759	Cache domain; Region: Cache_1; pfam02743
568206010760	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206010761	dimerization interface [polypeptide binding]; other site
568206010762	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206010763	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206010764	dimer interface [polypeptide binding]; other site
568206010765	putative CheW interface [polypeptide binding]; other site
568206010766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
568206010767	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
568206010768	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
568206010769	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
568206010770	FOG: PKD repeat [General function prediction only]; Region: COG3291
568206010771	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
568206010772	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
568206010773	BCCT family transporter; Region: BCCT; pfam02028
568206010774	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206010775	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568206010776	Coenzyme A binding pocket [chemical binding]; other site
568206010777	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206010778	heme-binding site [chemical binding]; other site
568206010779	Leucine rich repeat; Region: LRR_8; pfam13855
568206010780	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568206010781	Substrate binding site [chemical binding]; other site
568206010782	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206010783	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206010784	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206010785	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206010786	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568206010787	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568206010788	Leucine rich repeat; Region: LRR_8; pfam13855
568206010789	Leucine rich repeat; Region: LRR_8; pfam13855
568206010790	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
568206010791	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
568206010792	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
568206010793	PAS fold; Region: PAS_4; pfam08448
568206010794	PAS domain S-box; Region: sensory_box; TIGR00229
568206010795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206010796	putative active site [active]
568206010797	heme pocket [chemical binding]; other site
568206010798	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568206010799	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206010800	metal binding site [ion binding]; metal-binding site
568206010801	active site
568206010802	I-site; other site
568206010803	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568206010804	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
568206010805	Putative amidase domain; Region: Amidase_6; pfam12671
568206010806	epoxyqueuosine reductase; Region: TIGR00276
568206010807	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
568206010808	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
568206010809	Thioredoxin; Region: Thioredoxin_4; pfam13462
568206010810	Transglycosylase; Region: Transgly; pfam00912
568206010811	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
568206010812	nudix motif; other site
568206010813	hypothetical protein; Provisional; Region: PRK12378
568206010814	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
568206010815	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
568206010816	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568206010817	metal binding site 2 [ion binding]; metal-binding site
568206010818	putative DNA binding helix; other site
568206010819	metal binding site 1 [ion binding]; metal-binding site
568206010820	dimer interface [polypeptide binding]; other site
568206010821	structural Zn2+ binding site [ion binding]; other site
568206010822	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
568206010823	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
568206010824	catalytic triad [active]
568206010825	Ion channel; Region: Ion_trans_2; pfam07885
568206010826	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
568206010827	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
568206010828	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
568206010829	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
568206010830	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
568206010831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206010832	Walker A/P-loop; other site
568206010833	ATP binding site [chemical binding]; other site
568206010834	Q-loop/lid; other site
568206010835	ABC transporter signature motif; other site
568206010836	Walker B; other site
568206010837	D-loop; other site
568206010838	H-loop/switch region; other site
568206010839	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
568206010840	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206010841	inhibitor-cofactor binding pocket; inhibition site
568206010842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206010843	catalytic residue [active]
568206010844	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
568206010845	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
568206010846	active site
568206010847	dimer interface [polypeptide binding]; other site
568206010848	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
568206010849	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
568206010850	active site
568206010851	FMN binding site [chemical binding]; other site
568206010852	substrate binding site [chemical binding]; other site
568206010853	3Fe-4S cluster binding site [ion binding]; other site
568206010854	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
568206010855	domain_subunit interface; other site
568206010856	Predicted membrane protein [Function unknown]; Region: COG4129
568206010857	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
568206010858	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568206010859	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206010860	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
568206010861	Walker A/P-loop; other site
568206010862	ATP binding site [chemical binding]; other site
568206010863	Q-loop/lid; other site
568206010864	ABC transporter signature motif; other site
568206010865	Walker B; other site
568206010866	D-loop; other site
568206010867	H-loop/switch region; other site
568206010868	hypothetical protein; Provisional; Region: PRK13662
568206010869	YgaB-like protein; Region: YgaB; pfam14182
568206010870	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
568206010871	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568206010872	minor groove reading motif; other site
568206010873	helix-hairpin-helix signature motif; other site
568206010874	substrate binding pocket [chemical binding]; other site
568206010875	active site
568206010876	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
568206010877	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
568206010878	DNA binding and oxoG recognition site [nucleotide binding]
568206010879	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
568206010880	WVELL protein; Region: WVELL; pfam14043
568206010881	Small acid-soluble spore protein K family; Region: SspK; pfam08176
568206010882	YpzG-like protein; Region: YpzG; pfam14139
568206010883	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
568206010884	recombination regulator RecX; Provisional; Region: recX; PRK14135
568206010885	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
568206010886	TIGR01777 family protein; Region: yfcH
568206010887	putative NAD(P) binding site [chemical binding]; other site
568206010888	putative active site [active]
568206010889	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
568206010890	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
568206010891	active site
568206010892	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206010893	YfhE-like protein; Region: YfhE; pfam14152
568206010894	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
568206010895	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
568206010896	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568206010897	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
568206010898	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206010899	FeS/SAM binding site; other site
568206010900	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
568206010901	Pyruvate formate lyase 1; Region: PFL1; cd01678
568206010902	coenzyme A binding site [chemical binding]; other site
568206010903	active site
568206010904	catalytic residues [active]
568206010905	glycine loop; other site
568206010906	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206010907	active site
568206010908	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568206010909	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206010910	active site
568206010911	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568206010912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206010913	NAD(P) binding site [chemical binding]; other site
568206010914	active site
568206010915	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
568206010916	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
568206010917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206010918	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
568206010919	Ligand binding site; other site
568206010920	Putative Catalytic site; other site
568206010921	DXD motif; other site
568206010922	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568206010923	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
568206010924	active site
568206010925	Sm and related proteins; Region: Sm_like; cl00259
568206010926	heptamer interface [polypeptide binding]; other site
568206010927	Sm1 motif; other site
568206010928	hexamer interface [polypeptide binding]; other site
568206010929	RNA binding site [nucleotide binding]; other site
568206010930	Sm2 motif; other site
568206010931	Sm and related proteins; Region: Sm_like; cl00259
568206010932	heptamer interface [polypeptide binding]; other site
568206010933	Sm1 motif; other site
568206010934	hexamer interface [polypeptide binding]; other site
568206010935	RNA binding site [nucleotide binding]; other site
568206010936	Sm2 motif; other site
568206010937	potential frameshift: common BLAST hit: gi|49183501|ref|YP_026753.1| penicillin-binding protein, putative
568206010938	Beta-lactamase; Region: Beta-lactamase; pfam00144
568206010939	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568206010940	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
568206010941	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568206010942	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568206010943	active site turn [active]
568206010944	phosphorylation site [posttranslational modification]
568206010945	glutaminase A; Region: Gln_ase; TIGR03814
568206010946	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
568206010947	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
568206010948	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
568206010949	Domain of unknown function DUF; Region: DUF204; pfam02659
568206010950	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206010951	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206010952	non-specific DNA binding site [nucleotide binding]; other site
568206010953	salt bridge; other site
568206010954	sequence-specific DNA binding site [nucleotide binding]; other site
568206010955	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
568206010956	acetylornithine deacetylase; Validated; Region: PRK08596
568206010957	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
568206010958	metal binding site [ion binding]; metal-binding site
568206010959	S-methylmethionine transporter; Provisional; Region: PRK11387
568206010960	hypothetical protein; Validated; Region: PRK06748
568206010961	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
568206010962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206010963	Walker A motif; other site
568206010964	ATP binding site [chemical binding]; other site
568206010965	Walker B motif; other site
568206010966	arginine finger; other site
568206010967	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
568206010968	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
568206010969	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
568206010970	dimerization interface 3.5A [polypeptide binding]; other site
568206010971	active site
568206010972	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
568206010973	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
568206010974	active site
568206010975	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
568206010976	Haemolysin XhlA; Region: XhlA; pfam10779
568206010977	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
568206010978	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
568206010979	Phage-related protein [Function unknown]; Region: COG4722
568206010980	Phage tail protein; Region: Sipho_tail; pfam05709
568206010981	Domain of unknown function (DUF947); Region: DUF947; pfam06102
568206010982	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
568206010983	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
568206010984	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
568206010985	oligomerization interface [polypeptide binding]; other site
568206010986	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
568206010987	Phage capsid family; Region: Phage_capsid; pfam05065
568206010988	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
568206010989	Phage-related protein [Function unknown]; Region: COG4695; cl01923
568206010990	Phage Terminase; Region: Terminase_1; pfam03354
568206010991	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
568206010992	DNA binding site [nucleotide binding]
568206010993	active site
568206010994	Int/Topo IB signature motif; other site
568206010995	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
568206010996	Protein of unknown function (DUF3983); Region: DUF3983; pfam13137
568206010997	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
568206010998	putative metal binding site [ion binding]; other site
568206010999	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
568206011000	hypothetical protein; Validated; Region: PRK08116
568206011001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206011002	Walker A motif; other site
568206011003	ATP binding site [chemical binding]; other site
568206011004	Helix-turn-helix domain; Region: HTH_36; pfam13730
568206011005	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
568206011006	Inositol polyphosphate kinase; Region: IPK; cl12283
568206011007	Helix-turn-helix domain; Region: HTH_17; pfam12728
568206011008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206011009	non-specific DNA binding site [nucleotide binding]; other site
568206011010	salt bridge; other site
568206011011	sequence-specific DNA binding site [nucleotide binding]; other site
568206011012	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206011013	non-specific DNA binding site [nucleotide binding]; other site
568206011014	salt bridge; other site
568206011015	sequence-specific DNA binding site [nucleotide binding]; other site
568206011016	V-type ATP synthase subunit I; Validated; Region: PRK05771
568206011017	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
568206011018	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
568206011019	Int/Topo IB signature motif; other site
568206011020	hypothetical protein; Provisional; Region: PRK13670
568206011021	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
568206011022	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
568206011023	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
568206011024	protein binding site [polypeptide binding]; other site
568206011025	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
568206011026	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
568206011027	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
568206011028	active site
568206011029	nucleophile elbow; other site
568206011030	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
568206011031	Nucleoside recognition; Region: Gate; pfam07670
568206011032	Nucleoside recognition; Region: Gate; pfam07670
568206011033	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
568206011034	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
568206011035	active site
568206011036	(T/H)XGH motif; other site
568206011037	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
568206011038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206011039	S-adenosylmethionine binding site [chemical binding]; other site
568206011040	ylbH leader
568206011041	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
568206011042	Protein of unknown function (DUF964); Region: DUF964; pfam06133
568206011043	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568206011044	catalytic core [active]
568206011045	YlbE-like protein; Region: YlbE; pfam14003
568206011046	Putative coat protein; Region: YlbD_coat; pfam14071
568206011047	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
568206011048	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
568206011049	YugN-like family; Region: YugN; pfam08868
568206011050	formamidase; Provisional; Region: amiF; PRK13287
568206011051	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
568206011052	multimer interface [polypeptide binding]; other site
568206011053	active site
568206011054	catalytic triad [active]
568206011055	dimer interface [polypeptide binding]; other site
568206011056	cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737
568206011057	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
568206011058	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
568206011059	Subunit I/III interface [polypeptide binding]; other site
568206011060	Subunit III/IV interface [polypeptide binding]; other site
568206011061	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
568206011062	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
568206011063	D-pathway; other site
568206011064	Putative ubiquinol binding site [chemical binding]; other site
568206011065	Low-spin heme (heme b) binding site [chemical binding]; other site
568206011066	Putative water exit pathway; other site
568206011067	Binuclear center (heme o3/CuB) [ion binding]; other site
568206011068	K-pathway; other site
568206011069	Putative proton exit pathway; other site
568206011070	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
568206011071	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
568206011072	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
568206011073	Cytochrome c; Region: Cytochrom_C; pfam00034
568206011074	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
568206011075	UbiA prenyltransferase family; Region: UbiA; pfam01040
568206011076	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
568206011077	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
568206011078	pyruvate carboxylase; Reviewed; Region: PRK12999
568206011079	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568206011080	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
568206011081	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
568206011082	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
568206011083	active site
568206011084	catalytic residues [active]
568206011085	metal binding site [ion binding]; metal-binding site
568206011086	homodimer binding site [polypeptide binding]; other site
568206011087	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
568206011088	carboxyltransferase (CT) interaction site; other site
568206011089	biotinylation site [posttranslational modification]; other site
568206011090	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
568206011091	hypothetical protein; Provisional; Region: PRK13666
568206011092	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
568206011093	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
568206011094	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
568206011095	putative active site [active]
568206011096	PhoH-like protein; Region: PhoH; pfam02562
568206011097	hypothetical protein; Provisional; Region: PRK06733
568206011098	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
568206011099	YlaH-like protein; Region: YlaH; pfam14036
568206011100	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
568206011101	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
568206011102	G1 box; other site
568206011103	putative GEF interaction site [polypeptide binding]; other site
568206011104	GTP/Mg2+ binding site [chemical binding]; other site
568206011105	Switch I region; other site
568206011106	G2 box; other site
568206011107	G3 box; other site
568206011108	Switch II region; other site
568206011109	G4 box; other site
568206011110	G5 box; other site
568206011111	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
568206011112	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
568206011113	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
568206011114	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
568206011115	active site
568206011116	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
568206011117	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
568206011118	hypothetical protein; Provisional; Region: PRK04387
568206011119	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
568206011120	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
568206011121	homodimer interface [polypeptide binding]; other site
568206011122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011123	catalytic residue [active]
568206011124	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
568206011125	transglutaminase; Provisional; Region: tgl; PRK03187
568206011126	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
568206011127	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
568206011128	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
568206011129	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
568206011130	Domain of unknown function (DUF1885); Region: DUF1885; pfam08968
568206011131	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
568206011132	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206011133	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568206011134	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
568206011135	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568206011136	E3 interaction surface; other site
568206011137	lipoyl attachment site [posttranslational modification]; other site
568206011138	e3 binding domain; Region: E3_binding; pfam02817
568206011139	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
568206011140	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
568206011141	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
568206011142	alpha subunit interface [polypeptide binding]; other site
568206011143	TPP binding site [chemical binding]; other site
568206011144	heterodimer interface [polypeptide binding]; other site
568206011145	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568206011146	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
568206011147	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
568206011148	TPP-binding site [chemical binding]; other site
568206011149	heterodimer interface [polypeptide binding]; other site
568206011150	tetramer interface [polypeptide binding]; other site
568206011151	phosphorylation loop region [posttranslational modification]
568206011152	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
568206011153	active site
568206011154	catalytic residues [active]
568206011155	metal binding site [ion binding]; metal-binding site
568206011156	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206011157	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206011158	active site
568206011159	motif I; other site
568206011160	motif II; other site
568206011161	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206011162	hypothetical protein; Provisional; Region: PRK13667
568206011163	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
568206011164	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206011165	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
568206011166	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
568206011167	TrkA-N domain; Region: TrkA_N; pfam02254
568206011168	TrkA-C domain; Region: TrkA_C; pfam02080
568206011169	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
568206011170	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568206011171	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
568206011172	metal binding site [ion binding]; metal-binding site
568206011173	putative dimer interface [polypeptide binding]; other site
568206011174	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
568206011175	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
568206011176	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
568206011177	trimer interface [polypeptide binding]; other site
568206011178	active site
568206011179	substrate binding site [chemical binding]; other site
568206011180	CoA binding site [chemical binding]; other site
568206011181	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206011182	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206011183	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206011184	dimerization interface [polypeptide binding]; other site
568206011185	FOG: CBS domain [General function prediction only]; Region: COG0517
568206011186	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
568206011187	Antirepressor AbbA; Region: AbbA_antirepres; pfam14156
568206011188	Protein of unknown function (DUF458); Region: DUF458; pfam04308
568206011189	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
568206011190	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
568206011191	catalytic residues [active]
568206011192	Protein of unknown function (DUF3993); Region: DUF3993; pfam13158
568206011193	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568206011194	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
568206011195	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
568206011196	short chain dehydrogenase; Provisional; Region: PRK07677
568206011197	NAD(P) binding site [chemical binding]; other site
568206011198	substrate binding site [chemical binding]; other site
568206011199	homotetramer interface [polypeptide binding]; other site
568206011200	active site
568206011201	homodimer interface [polypeptide binding]; other site
568206011202	phosphodiesterase YaeI; Provisional; Region: PRK11340
568206011203	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
568206011204	putative active site [active]
568206011205	putative metal binding site [ion binding]; other site
568206011206	polyphosphate kinase; Provisional; Region: PRK05443
568206011207	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
568206011208	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
568206011209	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
568206011210	putative domain interface [polypeptide binding]; other site
568206011211	putative active site [active]
568206011212	catalytic site [active]
568206011213	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
568206011214	putative domain interface [polypeptide binding]; other site
568206011215	putative active site [active]
568206011216	catalytic site [active]
568206011217	exopolyphosphatase; Region: exo_poly_only; TIGR03706
568206011218	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568206011219	nucleotide binding site [chemical binding]; other site
568206011220	YkyB-like protein; Region: YkyB; pfam14177
568206011221	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
568206011222	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206011223	I-site; other site
568206011224	active site
568206011225	metal binding site [ion binding]; metal-binding site
568206011226	Phage lysis protein, holin; Region: Phage_holin; cl04675
568206011227	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206011228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206011229	putative substrate translocation pore; other site
568206011230	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206011231	Transcriptional regulator PadR-like family; Region: PadR; cl17335
568206011232	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
568206011233	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
568206011234	THF binding site; other site
568206011235	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
568206011236	substrate binding site [chemical binding]; other site
568206011237	THF binding site; other site
568206011238	zinc-binding site [ion binding]; other site
568206011239	Competence protein J (ComJ); Region: ComJ; pfam11033
568206011240	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
568206011241	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
568206011242	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206011243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206011244	dimer interface [polypeptide binding]; other site
568206011245	phosphorylation site [posttranslational modification]
568206011246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206011247	ATP binding site [chemical binding]; other site
568206011248	Mg2+ binding site [ion binding]; other site
568206011249	G-X-G motif; other site
568206011250	aminotransferase A; Validated; Region: PRK07683
568206011251	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206011252	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011253	homodimer interface [polypeptide binding]; other site
568206011254	catalytic residue [active]
568206011255	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206011256	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206011257	DNA binding site [nucleotide binding]
568206011258	domain linker motif; other site
568206011259	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
568206011260	putative dimerization interface [polypeptide binding]; other site
568206011261	putative ligand binding site [chemical binding]; other site
568206011262	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568206011263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206011264	dimer interface [polypeptide binding]; other site
568206011265	conserved gate region; other site
568206011266	putative PBP binding loops; other site
568206011267	ABC-ATPase subunit interface; other site
568206011268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206011269	dimer interface [polypeptide binding]; other site
568206011270	conserved gate region; other site
568206011271	putative PBP binding loops; other site
568206011272	ABC-ATPase subunit interface; other site
568206011273	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
568206011274	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
568206011275	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
568206011276	homodimer interface [polypeptide binding]; other site
568206011277	maltodextrin glucosidase; Provisional; Region: PRK10785
568206011278	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
568206011279	active site
568206011280	homodimer interface [polypeptide binding]; other site
568206011281	catalytic site [active]
568206011282	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568206011283	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
568206011284	Ca binding site [ion binding]; other site
568206011285	active site
568206011286	catalytic site [active]
568206011287	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
568206011288	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
568206011289	Walker A/P-loop; other site
568206011290	ATP binding site [chemical binding]; other site
568206011291	Q-loop/lid; other site
568206011292	ABC transporter signature motif; other site
568206011293	Walker B; other site
568206011294	D-loop; other site
568206011295	H-loop/switch region; other site
568206011296	TOBE domain; Region: TOBE_2; pfam08402
568206011297	hypothetical protein; Provisional; Region: PRK06720
568206011298	NAD(P) binding site [chemical binding]; other site
568206011299	RDD family; Region: RDD; pfam06271
568206011300	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
568206011301	Protein of unknown function (DUF3997); Region: DUF3997; pfam13162
568206011302	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
568206011303	Predicted ATPase [General function prediction only]; Region: COG3910
568206011304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206011305	Walker A/P-loop; other site
568206011306	ATP binding site [chemical binding]; other site
568206011307	Q-loop/lid; other site
568206011308	ABC transporter signature motif; other site
568206011309	Walker B; other site
568206011310	D-loop; other site
568206011311	H-loop/switch region; other site
568206011312	putative acyltransferase; Provisional; Region: PRK05790
568206011313	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
568206011314	dimer interface [polypeptide binding]; other site
568206011315	active site
568206011316	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
568206011317	nudix motif; other site
568206011318	Protein of unknown function (DUF3928); Region: DUF3928; pfam13065
568206011319	hypothetical protein; Validated; Region: PRK07668
568206011320	hypothetical protein; Validated; Region: PRK07668
568206011321	hypothetical protein; Validated; Region: PRK07668
568206011322	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206011323	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568206011324	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
568206011325	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206011326	NAD(P) binding site [chemical binding]; other site
568206011327	active site
568206011328	YvrJ protein family; Region: YvrJ; pfam12841
568206011329	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
568206011330	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
568206011331	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
568206011332	Phosphotransferase enzyme family; Region: APH; pfam01636
568206011333	Predicted amidohydrolase [General function prediction only]; Region: COG0388
568206011334	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
568206011335	putative active site [active]
568206011336	catalytic triad [active]
568206011337	putative dimer interface [polypeptide binding]; other site
568206011338	transaminase; Reviewed; Region: PRK08068
568206011339	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206011340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011341	homodimer interface [polypeptide binding]; other site
568206011342	catalytic residue [active]
568206011343	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
568206011344	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
568206011345	dimer interface [polypeptide binding]; other site
568206011346	active site
568206011347	catalytic residue [active]
568206011348	metal binding site [ion binding]; metal-binding site
568206011349	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552
568206011350	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
568206011351	methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754
568206011352	intersubunit interface [polypeptide binding]; other site
568206011353	active site
568206011354	Zn2+ binding site [ion binding]; other site
568206011355	ARD/ARD' family; Region: ARD; pfam03079
568206011356	Cupin domain; Region: Cupin_2; pfam07883
568206011357	Protein of unknown function (DUF3909); Region: DUF3909; pfam13077
568206011358	potential frameshift: common BLAST hit: gi|218905179|ref|YP_002453013.1| 2-hydroxy-3-oxopropionate reductase
568206011359	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
568206011360	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
568206011361	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
568206011362	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
568206011363	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568206011364	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206011365	metal binding site [ion binding]; metal-binding site
568206011366	active site
568206011367	I-site; other site
568206011368	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
568206011369	dimer interface [polypeptide binding]; other site
568206011370	FMN binding site [chemical binding]; other site
568206011371	Protein of unknown function (DUF3915); Region: DUF3915; pfam13054
568206011372	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
568206011373	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
568206011374	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
568206011375	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
568206011376	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
568206011377	dimerization domain swap beta strand [polypeptide binding]; other site
568206011378	regulatory protein interface [polypeptide binding]; other site
568206011379	active site
568206011380	regulatory phosphorylation site [posttranslational modification]; other site
568206011381	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568206011382	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
568206011383	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568206011384	active site turn [active]
568206011385	phosphorylation site [posttranslational modification]
568206011386	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
568206011387	HPr interaction site; other site
568206011388	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568206011389	active site
568206011390	phosphorylation site [posttranslational modification]
568206011391	transcriptional antiterminator BglG; Provisional; Region: PRK09772
568206011392	CAT RNA binding domain; Region: CAT_RBD; smart01061
568206011393	PRD domain; Region: PRD; pfam00874
568206011394	PRD domain; Region: PRD; pfam00874
568206011395	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206011396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206011397	active site
568206011398	motif I; other site
568206011399	motif II; other site
568206011400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206011401	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568206011402	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
568206011403	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
568206011404	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
568206011405	active site
568206011406	trimer interface [polypeptide binding]; other site
568206011407	allosteric site; other site
568206011408	active site lid [active]
568206011409	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568206011410	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
568206011411	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
568206011412	active site
568206011413	dimer interface [polypeptide binding]; other site
568206011414	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
568206011415	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206011416	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
568206011417	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
568206011418	Domain of unknown function (DUF309); Region: DUF309; pfam03745
568206011419	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206011420	Coenzyme A binding pocket [chemical binding]; other site
568206011421	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
568206011422	active site
568206011423	Predicted secreted protein [Function unknown]; Region: COG4086
568206011424	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
568206011425	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206011426	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
568206011427	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
568206011428	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
568206011429	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
568206011430	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
568206011431	stage V sporulation protein AD; Validated; Region: PRK08304
568206011432	stage V sporulation protein AD; Provisional; Region: PRK12404
568206011433	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
568206011434	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
568206011435	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
568206011436	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
568206011437	Na2 binding site [ion binding]; other site
568206011438	putative substrate binding site 1 [chemical binding]; other site
568206011439	Na binding site 1 [ion binding]; other site
568206011440	putative substrate binding site 2 [chemical binding]; other site
568206011441	sporulation sigma factor SigF; Validated; Region: PRK05572
568206011442	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206011443	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
568206011444	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206011445	DNA binding residues [nucleotide binding]
568206011446	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
568206011447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206011448	ATP binding site [chemical binding]; other site
568206011449	Mg2+ binding site [ion binding]; other site
568206011450	G-X-G motif; other site
568206011451	anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886
568206011452	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
568206011453	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206011454	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
568206011455	Predicted transcriptional regulators [Transcription]; Region: COG1725
568206011456	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206011457	DNA-binding site [nucleotide binding]; DNA binding site
568206011458	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206011459	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206011460	Walker A/P-loop; other site
568206011461	ATP binding site [chemical binding]; other site
568206011462	Q-loop/lid; other site
568206011463	ABC transporter signature motif; other site
568206011464	Walker B; other site
568206011465	D-loop; other site
568206011466	H-loop/switch region; other site
568206011467	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568206011468	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206011469	MarR family; Region: MarR; pfam01047
568206011470	MarR family; Region: MarR_2; cl17246
568206011471	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
568206011472	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
568206011473	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
568206011474	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
568206011475	oligomer interface [polypeptide binding]; other site
568206011476	metal binding site [ion binding]; metal-binding site
568206011477	metal binding site [ion binding]; metal-binding site
568206011478	putative Cl binding site [ion binding]; other site
568206011479	aspartate ring; other site
568206011480	basic sphincter; other site
568206011481	hydrophobic gate; other site
568206011482	periplasmic entrance; other site
568206011483	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
568206011484	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
568206011485	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
568206011486	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
568206011487	purine nucleoside phosphorylase; Provisional; Region: PRK08202
568206011488	phosphopentomutase; Provisional; Region: PRK05362
568206011489	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
568206011490	YtkA-like; Region: YtkA; pfam13115
568206011491	YtkA-like; Region: YtkA; pfam13115
568206011492	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
568206011493	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
568206011494	active site
568206011495	Int/Topo IB signature motif; other site
568206011496	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
568206011497	ferric uptake regulator; Provisional; Region: fur; PRK09462
568206011498	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568206011499	metal binding site 2 [ion binding]; metal-binding site
568206011500	putative DNA binding helix; other site
568206011501	metal binding site 1 [ion binding]; metal-binding site
568206011502	dimer interface [polypeptide binding]; other site
568206011503	structural Zn2+ binding site [ion binding]; other site
568206011504	stage II sporulation protein M; Region: spo_II_M; TIGR02831
568206011505	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206011506	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206011507	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
568206011508	dimer interface [polypeptide binding]; other site
568206011509	ADP-ribose binding site [chemical binding]; other site
568206011510	active site
568206011511	nudix motif; other site
568206011512	metal binding site [ion binding]; metal-binding site
568206011513	Protein of unknown function (DUF3936); Region: DUF3936; pfam13072
568206011514	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206011515	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206011516	active site
568206011517	catalytic tetrad [active]
568206011518	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206011519	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206011520	active site
568206011521	catalytic tetrad [active]
568206011522	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
568206011523	Protein of unknown function (DUF3886); Region: DUF3886; pfam13025
568206011524	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
568206011525	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
568206011526	putative active site [active]
568206011527	putative metal binding site [ion binding]; other site
568206011528	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568206011529	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
568206011530	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
568206011531	Predicted permease [General function prediction only]; Region: COG2056
568206011532	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
568206011533	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
568206011534	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206011535	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206011536	DNA binding site [nucleotide binding]
568206011537	domain linker motif; other site
568206011538	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568206011539	dimerization interface [polypeptide binding]; other site
568206011540	ligand binding site [chemical binding]; other site
568206011541	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568206011542	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206011543	Coenzyme A binding pocket [chemical binding]; other site
568206011544	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
568206011545	Protein of unknown function (DUF2552); Region: DUF2552; pfam10827
568206011546	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
568206011547	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
568206011548	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
568206011549	catalytic motif [active]
568206011550	Zn binding site [ion binding]; other site
568206011551	RibD C-terminal domain; Region: RibD_C; cl17279
568206011552	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
568206011553	Lumazine binding domain; Region: Lum_binding; pfam00677
568206011554	Lumazine binding domain; Region: Lum_binding; pfam00677
568206011555	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
568206011556	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
568206011557	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
568206011558	dimerization interface [polypeptide binding]; other site
568206011559	active site
568206011560	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
568206011561	homopentamer interface [polypeptide binding]; other site
568206011562	active site
568206011563	biotin synthase; Validated; Region: PRK06256
568206011564	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206011565	FeS/SAM binding site; other site
568206011566	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
568206011567	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
568206011568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206011569	S-adenosylmethionine binding site [chemical binding]; other site
568206011570	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206011571	TAP-like protein; Region: Abhydrolase_4; pfam08386
568206011572	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
568206011573	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
568206011574	substrate-cofactor binding pocket; other site
568206011575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011576	catalytic residue [active]
568206011577	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
568206011578	AAA domain; Region: AAA_26; pfam13500
568206011579	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
568206011580	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206011581	inhibitor-cofactor binding pocket; inhibition site
568206011582	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011583	catalytic residue [active]
568206011584	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
568206011585	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418
568206011586	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
568206011587	active site
568206011588	metal binding site [ion binding]; metal-binding site
568206011589	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568206011590	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
568206011591	active site
568206011592	catalytic triad [active]
568206011593	oxyanion hole [active]
568206011594	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206011595	dimerization interface [polypeptide binding]; other site
568206011596	putative DNA binding site [nucleotide binding]; other site
568206011597	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206011598	putative Zn2+ binding site [ion binding]; other site
568206011599	ornithine carbamoyltransferase; Provisional; Region: PRK00779
568206011600	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
568206011601	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
568206011602	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
568206011603	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206011604	inhibitor-cofactor binding pocket; inhibition site
568206011605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011606	catalytic residue [active]
568206011607	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
568206011608	nucleotide binding site [chemical binding]; other site
568206011609	N-acetyl-L-glutamate binding site [chemical binding]; other site
568206011610	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
568206011611	heterotetramer interface [polypeptide binding]; other site
568206011612	active site pocket [active]
568206011613	cleavage site
568206011614	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
568206011615	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
568206011616	YqzH-like protein; Region: YqzH; pfam14164
568206011617	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
568206011618	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206011619	NAD(P) binding site [chemical binding]; other site
568206011620	active site
568206011621	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206011622	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
568206011623	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679
568206011624	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
568206011625	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
568206011626	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
568206011627	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
568206011628	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
568206011629	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
568206011630	putative L-serine binding site [chemical binding]; other site
568206011631	ribonuclease Z; Region: RNase_Z; TIGR02651
568206011632	Protein of unknown function (DUF3932); Region: DUF3932; pfam13068
568206011633	DNA polymerase IV; Validated; Region: PRK01810
568206011634	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
568206011635	active site
568206011636	DNA binding site [nucleotide binding]
568206011637	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
568206011638	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
568206011639	peptidase T-like protein; Region: PepT-like; TIGR01883
568206011640	metal binding site [ion binding]; metal-binding site
568206011641	putative dimer interface [polypeptide binding]; other site
568206011642	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206011643	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206011644	Protein of unknown function (DUF3894); Region: DUF3894; pfam13033
568206011645	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
568206011646	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
568206011647	Predicted membrane protein [Function unknown]; Region: COG4129
568206011648	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
568206011649	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
568206011650	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568206011651	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
568206011652	Walker A/P-loop; other site
568206011653	ATP binding site [chemical binding]; other site
568206011654	Q-loop/lid; other site
568206011655	ABC transporter signature motif; other site
568206011656	Walker B; other site
568206011657	D-loop; other site
568206011658	H-loop/switch region; other site
568206011659	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568206011660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206011661	dimer interface [polypeptide binding]; other site
568206011662	conserved gate region; other site
568206011663	putative PBP binding loops; other site
568206011664	ABC-ATPase subunit interface; other site
568206011665	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568206011666	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568206011667	substrate binding pocket [chemical binding]; other site
568206011668	membrane-bound complex binding site; other site
568206011669	hinge residues; other site
568206011670	Disulphide isomerase; Region: Disulph_isomer; pfam06491
568206011671	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
568206011672	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
568206011673	nudix motif; other site
568206011674	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
568206011675	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
568206011676	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568206011677	E3 interaction surface; other site
568206011678	lipoyl attachment site [posttranslational modification]; other site
568206011679	e3 binding domain; Region: E3_binding; pfam02817
568206011680	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
568206011681	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
568206011682	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
568206011683	alpha subunit interface [polypeptide binding]; other site
568206011684	TPP binding site [chemical binding]; other site
568206011685	heterodimer interface [polypeptide binding]; other site
568206011686	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568206011687	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
568206011688	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
568206011689	tetramer interface [polypeptide binding]; other site
568206011690	TPP-binding site [chemical binding]; other site
568206011691	heterodimer interface [polypeptide binding]; other site
568206011692	phosphorylation loop region [posttranslational modification]
568206011693	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
568206011694	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
568206011695	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206011696	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568206011697	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568206011698	nucleotide binding site [chemical binding]; other site
568206011699	Acetokinase family; Region: Acetate_kinase; cl17229
568206011700	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
568206011701	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
568206011702	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
568206011703	NAD binding site [chemical binding]; other site
568206011704	Phe binding site; other site
568206011705	phosphate butyryltransferase; Validated; Region: PRK07742
568206011706	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
568206011707	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206011708	putative active site [active]
568206011709	heme pocket [chemical binding]; other site
568206011710	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206011711	putative active site [active]
568206011712	heme pocket [chemical binding]; other site
568206011713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206011714	Walker A motif; other site
568206011715	ATP binding site [chemical binding]; other site
568206011716	Walker B motif; other site
568206011717	arginine finger; other site
568206011718	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
568206011719	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
568206011720	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
568206011721	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
568206011722	active site
568206011723	catalytic site [active]
568206011724	metal binding site [ion binding]; metal-binding site
568206011725	dimer interface [polypeptide binding]; other site
568206011726	YycC-like protein; Region: YycC; pfam14174
568206011727	conserved hypothetical integral membrane protein; Region: TIGR03766
568206011728	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
568206011729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206011730	active site
568206011731	phosphorylation site [posttranslational modification]
568206011732	intermolecular recognition site; other site
568206011733	dimerization interface [polypeptide binding]; other site
568206011734	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
568206011735	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
568206011736	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
568206011737	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
568206011738	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
568206011739	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
568206011740	Walker A/P-loop; other site
568206011741	ATP binding site [chemical binding]; other site
568206011742	Q-loop/lid; other site
568206011743	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
568206011744	ABC transporter signature motif; other site
568206011745	Walker B; other site
568206011746	D-loop; other site
568206011747	H-loop/switch region; other site
568206011748	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
568206011749	arginine repressor; Provisional; Region: PRK04280
568206011750	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
568206011751	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
568206011752	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206011753	RNA binding surface [nucleotide binding]; other site
568206011754	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
568206011755	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
568206011756	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
568206011757	TPP-binding site; other site
568206011758	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568206011759	PYR/PP interface [polypeptide binding]; other site
568206011760	dimer interface [polypeptide binding]; other site
568206011761	TPP binding site [chemical binding]; other site
568206011762	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568206011763	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
568206011764	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
568206011765	substrate binding pocket [chemical binding]; other site
568206011766	chain length determination region; other site
568206011767	substrate-Mg2+ binding site; other site
568206011768	catalytic residues [active]
568206011769	aspartate-rich region 1; other site
568206011770	active site lid residues [active]
568206011771	aspartate-rich region 2; other site
568206011772	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063
568206011773	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
568206011774	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
568206011775	generic binding surface II; other site
568206011776	generic binding surface I; other site
568206011777	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
568206011778	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
568206011779	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
568206011780	homodimer interface [polypeptide binding]; other site
568206011781	NADP binding site [chemical binding]; other site
568206011782	substrate binding site [chemical binding]; other site
568206011783	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
568206011784	putative RNA binding site [nucleotide binding]; other site
568206011785	Asp23 family; Region: Asp23; pfam03780
568206011786	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
568206011787	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568206011788	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
568206011789	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
568206011790	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
568206011791	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
568206011792	carboxyltransferase (CT) interaction site; other site
568206011793	biotinylation site [posttranslational modification]; other site
568206011794	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
568206011795	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
568206011796	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
568206011797	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
568206011798	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
568206011799	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
568206011800	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
568206011801	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
568206011802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206011803	Walker A motif; other site
568206011804	ATP binding site [chemical binding]; other site
568206011805	Walker B motif; other site
568206011806	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
568206011807	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206011808	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206011809	elongation factor P; Validated; Region: PRK00529
568206011810	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
568206011811	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
568206011812	RNA binding site [nucleotide binding]; other site
568206011813	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
568206011814	RNA binding site [nucleotide binding]; other site
568206011815	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
568206011816	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
568206011817	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
568206011818	active site
568206011819	Dehydroquinase class II; Region: DHquinase_II; pfam01220
568206011820	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
568206011821	trimer interface [polypeptide binding]; other site
568206011822	active site
568206011823	dimer interface [polypeptide binding]; other site
568206011824	Conserved membrane protein YqhR; Region: YqhR; pfam11085
568206011825	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
568206011826	CCC1-related family of proteins; Region: CCC1_like; cl00278
568206011827	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
568206011828	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
568206011829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206011830	motif II; other site
568206011831	manganese transport transcriptional regulator; Provisional; Region: PRK03902
568206011832	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
568206011833	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
568206011834	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
568206011835	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206011836	FeS/SAM binding site; other site
568206011837	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
568206011838	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568206011839	active site residue [active]
568206011840	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206011841	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206011842	DNA binding site [nucleotide binding]
568206011843	domain linker motif; other site
568206011844	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568206011845	putative dimerization interface [polypeptide binding]; other site
568206011846	putative ligand binding site [chemical binding]; other site
568206011847	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206011848	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206011849	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
568206011850	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
568206011851	Protein of unknown function (DUF3975); Region: DUF3975; pfam13126
568206011852	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
568206011853	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
568206011854	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
568206011855	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
568206011856	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206011857	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206011858	Walker A/P-loop; other site
568206011859	ATP binding site [chemical binding]; other site
568206011860	Q-loop/lid; other site
568206011861	ABC transporter signature motif; other site
568206011862	Walker B; other site
568206011863	D-loop; other site
568206011864	H-loop/switch region; other site
568206011865	Predicted transcriptional regulators [Transcription]; Region: COG1725
568206011866	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206011867	DNA-binding site [nucleotide binding]; DNA binding site
568206011868	Protein of unknown function (DUF3929); Region: DUF3929; pfam13066
568206011869	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
568206011870	tetramer interface [polypeptide binding]; other site
568206011871	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011872	catalytic residue [active]
568206011873	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
568206011874	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
568206011875	tetramer interface [polypeptide binding]; other site
568206011876	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011877	catalytic residue [active]
568206011878	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
568206011879	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
568206011880	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
568206011881	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568206011882	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206011883	ATP binding site [chemical binding]; other site
568206011884	putative Mg++ binding site [ion binding]; other site
568206011885	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206011886	nucleotide binding region [chemical binding]; other site
568206011887	ATP-binding site [chemical binding]; other site
568206011888	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
568206011889	YqzE-like protein; Region: YqzE; pfam14038
568206011890	shikimate kinase; Reviewed; Region: aroK; PRK00131
568206011891	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
568206011892	ADP binding site [chemical binding]; other site
568206011893	magnesium binding site [ion binding]; other site
568206011894	putative shikimate binding site; other site
568206011895	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
568206011896	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
568206011897	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
568206011898	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
568206011899	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
568206011900	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
568206011901	Type II/IV secretion system protein; Region: T2SE; pfam00437
568206011902	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568206011903	Walker A motif; other site
568206011904	ATP binding site [chemical binding]; other site
568206011905	Walker B motif; other site
568206011906	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206011907	putative DNA binding site [nucleotide binding]; other site
568206011908	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
568206011909	putative Zn2+ binding site [ion binding]; other site
568206011910	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
568206011911	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
568206011912	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
568206011913	Protein of unknown function (DUF3912); Region: DUF3912; pfam13051
568206011914	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
568206011915	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568206011916	Protein of unknown function (DUF3966); Region: DUF3966; pfam13110
568206011917	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
568206011918	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
568206011919	active site
568206011920	homodimer interface [polypeptide binding]; other site
568206011921	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
568206011922	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
568206011923	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
568206011924	substrate binding pocket [chemical binding]; other site
568206011925	dimer interface [polypeptide binding]; other site
568206011926	inhibitor binding site; inhibition site
568206011927	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
568206011928	B12 binding site [chemical binding]; other site
568206011929	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
568206011930	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
568206011931	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
568206011932	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
568206011933	FAD binding site [chemical binding]; other site
568206011934	cystathionine gamma-synthase; Reviewed; Region: PRK08247
568206011935	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568206011936	homodimer interface [polypeptide binding]; other site
568206011937	substrate-cofactor binding pocket; other site
568206011938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011939	catalytic residue [active]
568206011940	cystathionine beta-lyase; Provisional; Region: PRK08064
568206011941	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568206011942	homodimer interface [polypeptide binding]; other site
568206011943	substrate-cofactor binding pocket; other site
568206011944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206011945	catalytic residue [active]
568206011946	Isochorismatase family; Region: Isochorismatase; pfam00857
568206011947	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
568206011948	catalytic triad [active]
568206011949	conserved cis-peptide bond; other site
568206011950	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206011951	dimerization interface [polypeptide binding]; other site
568206011952	putative DNA binding site [nucleotide binding]; other site
568206011953	putative Zn2+ binding site [ion binding]; other site
568206011954	Uncharacterized conserved protein [Function unknown]; Region: COG1565
568206011955	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
568206011956	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
568206011957	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
568206011958	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568206011959	nucleotide binding site [chemical binding]; other site
568206011960	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
568206011961	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
568206011962	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
568206011963	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
568206011964	potential frameshift: common BLAST hit: gi|49187166|ref|YP_030418.1| nucleotidyl transferase family protein
568206011965	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
568206011966	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
568206011967	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
568206011968	active site
568206011969	Substrate binding site; other site
568206011970	Mg++ binding site; other site
568206011971	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
568206011972	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
568206011973	metal binding site [ion binding]; metal-binding site
568206011974	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
568206011975	PhoU domain; Region: PhoU; pfam01895
568206011976	PhoU domain; Region: PhoU; pfam01895
568206011977	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
568206011978	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
568206011979	Walker A/P-loop; other site
568206011980	ATP binding site [chemical binding]; other site
568206011981	Q-loop/lid; other site
568206011982	ABC transporter signature motif; other site
568206011983	Walker B; other site
568206011984	D-loop; other site
568206011985	H-loop/switch region; other site
568206011986	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
568206011987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206011988	dimer interface [polypeptide binding]; other site
568206011989	conserved gate region; other site
568206011990	putative PBP binding loops; other site
568206011991	ABC-ATPase subunit interface; other site
568206011992	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
568206011993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206011994	dimer interface [polypeptide binding]; other site
568206011995	conserved gate region; other site
568206011996	putative PBP binding loops; other site
568206011997	ABC-ATPase subunit interface; other site
568206011998	PBP superfamily domain; Region: PBP_like_2; cl17296
568206011999	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568206012000	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206012001	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206012002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206012003	putative substrate translocation pore; other site
568206012004	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206012005	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
568206012006	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
568206012007	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
568206012008	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
568206012009	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
568206012010	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
568206012011	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
568206012012	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568206012013	metal binding site 2 [ion binding]; metal-binding site
568206012014	putative DNA binding helix; other site
568206012015	metal binding site 1 [ion binding]; metal-binding site
568206012016	dimer interface [polypeptide binding]; other site
568206012017	structural Zn2+ binding site [ion binding]; other site
568206012018	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
568206012019	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206012020	ABC-ATPase subunit  interface; other site
568206012021	dimer interface [polypeptide binding]; other site
568206012022	putative PBP binding regions; other site
568206012023	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
568206012024	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
568206012025	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206012026	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206012027	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206012028	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
568206012029	endonuclease IV; Provisional; Region: PRK01060
568206012030	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
568206012031	AP (apurinic/apyrimidinic) site pocket; other site
568206012032	DNA interaction; other site
568206012033	Metal-binding active site; metal-binding site
568206012034	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
568206012035	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568206012036	ATP binding site [chemical binding]; other site
568206012037	Mg++ binding site [ion binding]; other site
568206012038	motif III; other site
568206012039	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206012040	nucleotide binding region [chemical binding]; other site
568206012041	ATP-binding site [chemical binding]; other site
568206012042	YqfQ-like protein; Region: YqfQ; pfam14181
568206012043	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
568206012044	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
568206012045	Uncharacterized conserved protein [Function unknown]; Region: COG0327
568206012046	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
568206012047	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
568206012048	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
568206012049	Uncharacterized conserved protein [Function unknown]; Region: COG0327
568206012050	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
568206012051	Family of unknown function (DUF633); Region: DUF633; pfam04816
568206012052	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
568206012053	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
568206012054	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
568206012055	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
568206012056	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
568206012057	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206012058	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
568206012059	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206012060	DNA binding residues [nucleotide binding]
568206012061	DNA primase; Validated; Region: dnaG; PRK05667
568206012062	CHC2 zinc finger; Region: zf-CHC2; pfam01807
568206012063	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
568206012064	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
568206012065	active site
568206012066	metal binding site [ion binding]; metal-binding site
568206012067	interdomain interaction site; other site
568206012068	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
568206012069	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
568206012070	PEP synthetase regulatory protein; Provisional; Region: PRK05339
568206012071	HTH domain; Region: HTH_11; pfam08279
568206012072	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
568206012073	FOG: CBS domain [General function prediction only]; Region: COG0517
568206012074	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
568206012075	Recombination protein O N terminal; Region: RecO_N; pfam11967
568206012076	Recombination protein O C terminal; Region: RecO_C; pfam02565
568206012077	YqzL-like protein; Region: YqzL; pfam14006
568206012078	GTPase Era; Reviewed; Region: era; PRK00089
568206012079	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
568206012080	G1 box; other site
568206012081	GTP/Mg2+ binding site [chemical binding]; other site
568206012082	Switch I region; other site
568206012083	G2 box; other site
568206012084	Switch II region; other site
568206012085	G3 box; other site
568206012086	G4 box; other site
568206012087	G5 box; other site
568206012088	KH domain; Region: KH_2; pfam07650
568206012089	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
568206012090	active site
568206012091	catalytic motif [active]
568206012092	Zn binding site [ion binding]; other site
568206012093	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
568206012094	metal-binding heat shock protein; Provisional; Region: PRK00016
568206012095	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
568206012096	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
568206012097	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206012098	Zn2+ binding site [ion binding]; other site
568206012099	Mg2+ binding site [ion binding]; other site
568206012100	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
568206012101	PhoH-like protein; Region: PhoH; pfam02562
568206012102	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
568206012103	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
568206012104	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
568206012105	Yqey-like protein; Region: YqeY; pfam09424
568206012106	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
568206012107	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
568206012108	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
568206012109	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206012110	FeS/SAM binding site; other site
568206012111	TRAM domain; Region: TRAM; cl01282
568206012112	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
568206012113	RNA methyltransferase, RsmE family; Region: TIGR00046
568206012114	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
568206012115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206012116	S-adenosylmethionine binding site [chemical binding]; other site
568206012117	chaperone protein DnaJ; Provisional; Region: PRK14280
568206012118	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
568206012119	HSP70 interaction site [polypeptide binding]; other site
568206012120	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
568206012121	substrate binding site [polypeptide binding]; other site
568206012122	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
568206012123	Zn binding sites [ion binding]; other site
568206012124	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
568206012125	dimer interface [polypeptide binding]; other site
568206012126	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
568206012127	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
568206012128	nucleotide binding site [chemical binding]; other site
568206012129	NEF interaction site [polypeptide binding]; other site
568206012130	SBD interface [polypeptide binding]; other site
568206012131	GrpE; Region: GrpE; pfam01025
568206012132	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
568206012133	dimer interface [polypeptide binding]; other site
568206012134	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
568206012135	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
568206012136	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
568206012137	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
568206012138	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206012139	FeS/SAM binding site; other site
568206012140	HemN C-terminal domain; Region: HemN_C; pfam06969
568206012141	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206012142	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
568206012143	GTP-binding protein LepA; Provisional; Region: PRK05433
568206012144	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
568206012145	G1 box; other site
568206012146	putative GEF interaction site [polypeptide binding]; other site
568206012147	GTP/Mg2+ binding site [chemical binding]; other site
568206012148	Switch I region; other site
568206012149	G2 box; other site
568206012150	G3 box; other site
568206012151	Switch II region; other site
568206012152	G4 box; other site
568206012153	G5 box; other site
568206012154	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
568206012155	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
568206012156	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
568206012157	Protein of unknown function (DUF3679); Region: DUF3679; pfam12438
568206012158	germination protease; Provisional; Region: PRK02858
568206012159	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
568206012160	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
568206012161	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
568206012162	YqzM-like protein; Region: YqzM; pfam14141
568206012163	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
568206012164	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
568206012165	Competence protein; Region: Competence; pfam03772
568206012166	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206012167	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
568206012168	catalytic motif [active]
568206012169	Zn binding site [ion binding]; other site
568206012170	SLBB domain; Region: SLBB; pfam10531
568206012171	comEA protein; Region: comE; TIGR01259
568206012172	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
568206012173	late competence protein ComER; Validated; Region: PRK07680
568206012174	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
568206012175	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
568206012176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206012177	S-adenosylmethionine binding site [chemical binding]; other site
568206012178	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
568206012179	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206012180	Zn2+ binding site [ion binding]; other site
568206012181	Mg2+ binding site [ion binding]; other site
568206012182	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
568206012183	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
568206012184	active site
568206012185	(T/H)XGH motif; other site
568206012186	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
568206012187	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
568206012188	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
568206012189	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
568206012190	shikimate binding site; other site
568206012191	NAD(P) binding site [chemical binding]; other site
568206012192	GTPase YqeH; Provisional; Region: PRK13796
568206012193	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
568206012194	GTP/Mg2+ binding site [chemical binding]; other site
568206012195	G4 box; other site
568206012196	G5 box; other site
568206012197	G1 box; other site
568206012198	Switch I region; other site
568206012199	G2 box; other site
568206012200	G3 box; other site
568206012201	Switch II region; other site
568206012202	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
568206012203	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206012204	active site
568206012205	motif I; other site
568206012206	motif II; other site
568206012207	Sporulation inhibitor A; Region: Sda; pfam08970
568206012208	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
568206012209	sporulation sigma factor SigK; Reviewed; Region: PRK05803
568206012210	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206012211	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206012212	DNA binding residues [nucleotide binding]
568206012213	Peptidase propeptide and YPEB domain; Region: PepSY; cl15480
568206012214	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
568206012215	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
568206012216	dimer interface [polypeptide binding]; other site
568206012217	FMN binding site [chemical binding]; other site
568206012218	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568206012219	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
568206012220	synthetase active site [active]
568206012221	NTP binding site [chemical binding]; other site
568206012222	metal binding site [ion binding]; metal-binding site
568206012223	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
568206012224	dimer interface [polypeptide binding]; other site
568206012225	Alkaline phosphatase homologues; Region: alkPPc; smart00098
568206012226	active site
568206012227	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568206012228	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206012229	Coenzyme A binding pocket [chemical binding]; other site
568206012230	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
568206012231	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206012232	DoxX; Region: DoxX; cl17842
568206012233	CHAT domain; Region: CHAT; cl17868
568206012234	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
568206012235	catalytic core [active]
568206012236	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
568206012237	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
568206012238	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
568206012239	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
568206012240	putative active site [active]
568206012241	catalytic triad [active]
568206012242	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
568206012243	putative integrin binding motif; other site
568206012244	PA/protease domain interface [polypeptide binding]; other site
568206012245	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
568206012246	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
568206012247	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
568206012248	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
568206012249	cofactor binding site; other site
568206012250	metal binding site [ion binding]; metal-binding site
568206012251	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
568206012252	aromatic arch; other site
568206012253	DCoH dimer interaction site [polypeptide binding]; other site
568206012254	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
568206012255	DCoH tetramer interaction site [polypeptide binding]; other site
568206012256	substrate binding site [chemical binding]; other site
568206012257	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568206012258	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206012259	active site
568206012260	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
568206012261	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206012262	putative metal binding site [ion binding]; other site
568206012263	Predicted membrane protein [Function unknown]; Region: COG2259
568206012264	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
568206012265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206012266	non-specific DNA binding site [nucleotide binding]; other site
568206012267	salt bridge; other site
568206012268	sequence-specific DNA binding site [nucleotide binding]; other site
568206012269	Cupin domain; Region: Cupin_2; pfam07883
568206012270	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
568206012271	dimer interaction site [polypeptide binding]; other site
568206012272	substrate-binding tunnel; other site
568206012273	active site
568206012274	catalytic site [active]
568206012275	substrate binding site [chemical binding]; other site
568206012276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206012277	Coenzyme A binding pocket [chemical binding]; other site
568206012278	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206012279	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568206012280	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
568206012281	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
568206012282	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568206012283	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568206012284	Walker A/P-loop; other site
568206012285	ATP binding site [chemical binding]; other site
568206012286	Q-loop/lid; other site
568206012287	ABC transporter signature motif; other site
568206012288	Walker B; other site
568206012289	D-loop; other site
568206012290	H-loop/switch region; other site
568206012291	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
568206012292	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206012293	ABC-ATPase subunit  interface; other site
568206012294	dimer interface [polypeptide binding]; other site
568206012295	putative PBP binding regions; other site
568206012296	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
568206012297	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
568206012298	intersubunit interface [polypeptide binding]; other site
568206012299	YrhC-like protein; Region: YrhC; pfam14143
568206012300	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
568206012301	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
568206012302	putative catalytic cysteine [active]
568206012303	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
568206012304	putative active site [active]
568206012305	metal binding site [ion binding]; metal-binding site
568206012306	cystathionine beta-lyase; Provisional; Region: PRK07671
568206012307	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568206012308	homodimer interface [polypeptide binding]; other site
568206012309	substrate-cofactor binding pocket; other site
568206012310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206012311	catalytic residue [active]
568206012312	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
568206012313	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
568206012314	dimer interface [polypeptide binding]; other site
568206012315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206012316	catalytic residue [active]
568206012317	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
568206012318	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
568206012319	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206012320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206012321	S-adenosylmethionine binding site [chemical binding]; other site
568206012322	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
568206012323	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
568206012324	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568206012325	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568206012326	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206012327	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
568206012328	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
568206012329	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
568206012330	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
568206012331	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
568206012332	ATP-binding site [chemical binding]; other site
568206012333	Sugar specificity; other site
568206012334	Pyrimidine base specificity; other site
568206012335	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
568206012336	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
568206012337	Peptidase family U32; Region: Peptidase_U32; pfam01136
568206012338	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
568206012339	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
568206012340	Peptidase family U32; Region: Peptidase_U32; pfam01136
568206012341	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
568206012342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206012343	S-adenosylmethionine binding site [chemical binding]; other site
568206012344	YceG-like family; Region: YceG; pfam02618
568206012345	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
568206012346	dimerization interface [polypeptide binding]; other site
568206012347	hypothetical protein; Provisional; Region: PRK13678
568206012348	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
568206012349	hypothetical protein; Provisional; Region: PRK05473
568206012350	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
568206012351	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
568206012352	motif 1; other site
568206012353	active site
568206012354	motif 2; other site
568206012355	motif 3; other site
568206012356	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
568206012357	DHHA1 domain; Region: DHHA1; pfam02272
568206012358	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568206012359	Domain of unknown function DUF20; Region: UPF0118; pfam01594
568206012360	Protein of unknown function (DUF3918); Region: DUF3918; pfam13056
568206012361	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
568206012362	AAA domain; Region: AAA_30; pfam13604
568206012363	Family description; Region: UvrD_C_2; pfam13538
568206012364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206012365	TPR motif; other site
568206012366	TPR repeat; Region: TPR_11; pfam13414
568206012367	binding surface
568206012368	TPR repeat; Region: TPR_11; pfam13414
568206012369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206012370	binding surface
568206012371	TPR motif; other site
568206012372	TPR repeat; Region: TPR_11; pfam13414
568206012373	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
568206012374	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
568206012375	Ligand Binding Site [chemical binding]; other site
568206012376	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
568206012377	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
568206012378	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206012379	catalytic residue [active]
568206012380	Predicted transcriptional regulator [Transcription]; Region: COG1959
568206012381	Transcriptional regulator; Region: Rrf2; pfam02082
568206012382	recombination factor protein RarA; Reviewed; Region: PRK13342
568206012383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206012384	Walker A motif; other site
568206012385	ATP binding site [chemical binding]; other site
568206012386	Walker B motif; other site
568206012387	arginine finger; other site
568206012388	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
568206012389	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
568206012390	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
568206012391	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
568206012392	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
568206012393	putative ATP binding site [chemical binding]; other site
568206012394	putative substrate interface [chemical binding]; other site
568206012395	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
568206012396	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
568206012397	dimer interface [polypeptide binding]; other site
568206012398	anticodon binding site; other site
568206012399	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
568206012400	homodimer interface [polypeptide binding]; other site
568206012401	motif 1; other site
568206012402	active site
568206012403	motif 2; other site
568206012404	GAD domain; Region: GAD; pfam02938
568206012405	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
568206012406	motif 3; other site
568206012407	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
568206012408	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
568206012409	dimer interface [polypeptide binding]; other site
568206012410	motif 1; other site
568206012411	active site
568206012412	motif 2; other site
568206012413	motif 3; other site
568206012414	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
568206012415	anticodon binding site; other site
568206012416	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
568206012417	putative active site [active]
568206012418	dimerization interface [polypeptide binding]; other site
568206012419	putative tRNAtyr binding site [nucleotide binding]; other site
568206012420	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
568206012421	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206012422	Zn2+ binding site [ion binding]; other site
568206012423	Mg2+ binding site [ion binding]; other site
568206012424	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568206012425	synthetase active site [active]
568206012426	NTP binding site [chemical binding]; other site
568206012427	metal binding site [ion binding]; metal-binding site
568206012428	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
568206012429	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
568206012430	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206012431	active site
568206012432	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
568206012433	DHH family; Region: DHH; pfam01368
568206012434	DHHA1 domain; Region: DHHA1; pfam02272
568206012435	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
568206012436	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568206012437	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
568206012438	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
568206012439	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
568206012440	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
568206012441	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
568206012442	Protein export membrane protein; Region: SecD_SecF; pfam02355
568206012443	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
568206012444	stage V sporulation protein B; Region: spore_V_B; TIGR02900
568206012445	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568206012446	Predicted membrane protein [Function unknown]; Region: COG2323
568206012447	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
568206012448	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
568206012449	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
568206012450	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
568206012451	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
568206012452	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
568206012453	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
568206012454	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
568206012455	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206012456	Walker A motif; other site
568206012457	ATP binding site [chemical binding]; other site
568206012458	Walker B motif; other site
568206012459	arginine finger; other site
568206012460	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
568206012461	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
568206012462	RuvA N terminal domain; Region: RuvA_N; pfam01330
568206012463	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
568206012464	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
568206012465	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
568206012466	putative ligand binding residues [chemical binding]; other site
568206012467	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
568206012468	BofC C-terminal domain; Region: BofC_C; pfam08955
568206012469	EamA-like transporter family; Region: EamA; pfam00892
568206012470	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206012471	EamA-like transporter family; Region: EamA; pfam00892
568206012472	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206012473	dimerization interface [polypeptide binding]; other site
568206012474	putative DNA binding site [nucleotide binding]; other site
568206012475	putative Zn2+ binding site [ion binding]; other site
568206012476	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
568206012477	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568206012478	quinolinate synthetase; Provisional; Region: PRK09375
568206012479	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
568206012480	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
568206012481	dimerization interface [polypeptide binding]; other site
568206012482	active site
568206012483	L-aspartate oxidase; Provisional; Region: PRK08071
568206012484	L-aspartate oxidase; Provisional; Region: PRK06175
568206012485	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
568206012486	cysteine desulfurase; Provisional; Region: PRK02948
568206012487	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
568206012488	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206012489	catalytic residue [active]
568206012490	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
568206012491	HTH domain; Region: HTH_11; pfam08279
568206012492	3H domain; Region: 3H; pfam02829
568206012493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
568206012494	MOSC domain; Region: MOSC; pfam03473
568206012495	3-alpha domain; Region: 3-alpha; pfam03475
568206012496	prephenate dehydratase; Provisional; Region: PRK11898
568206012497	Prephenate dehydratase; Region: PDT; pfam00800
568206012498	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
568206012499	putative L-Phe binding site [chemical binding]; other site
568206012500	FtsX-like permease family; Region: FtsX; pfam02687
568206012501	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206012502	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206012503	FtsX-like permease family; Region: FtsX; pfam02687
568206012504	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206012505	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206012506	Walker A/P-loop; other site
568206012507	ATP binding site [chemical binding]; other site
568206012508	Q-loop/lid; other site
568206012509	ABC transporter signature motif; other site
568206012510	Walker B; other site
568206012511	D-loop; other site
568206012512	H-loop/switch region; other site
568206012513	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206012514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
568206012515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206012516	ATP binding site [chemical binding]; other site
568206012517	Mg2+ binding site [ion binding]; other site
568206012518	G-X-G motif; other site
568206012519	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206012520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206012521	active site
568206012522	phosphorylation site [posttranslational modification]
568206012523	intermolecular recognition site; other site
568206012524	dimerization interface [polypeptide binding]; other site
568206012525	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206012526	DNA binding site [nucleotide binding]
568206012527	GTPase CgtA; Reviewed; Region: obgE; PRK12297
568206012528	GTP1/OBG; Region: GTP1_OBG; pfam01018
568206012529	Obg GTPase; Region: Obg; cd01898
568206012530	G1 box; other site
568206012531	GTP/Mg2+ binding site [chemical binding]; other site
568206012532	Switch I region; other site
568206012533	G2 box; other site
568206012534	G3 box; other site
568206012535	Switch II region; other site
568206012536	G4 box; other site
568206012537	G5 box; other site
568206012538	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
568206012539	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
568206012540	hypothetical protein; Provisional; Region: PRK14553
568206012541	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
568206012542	Ribosomal protein L21 leader
568206012543	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
568206012544	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
568206012545	homodimer interface [polypeptide binding]; other site
568206012546	oligonucleotide binding site [chemical binding]; other site
568206012547	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
568206012548	Peptidase family M50; Region: Peptidase_M50; pfam02163
568206012549	active site
568206012550	putative substrate binding region [chemical binding]; other site
568206012551	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206012552	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206012553	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
568206012554	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
568206012555	Switch I; other site
568206012556	Switch II; other site
568206012557	septum formation inhibitor; Reviewed; Region: minC; PRK00513
568206012558	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
568206012559	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
568206012560	rod shape-determining protein MreC; Provisional; Region: PRK13922
568206012561	rod shape-determining protein MreC; Region: MreC; pfam04085
568206012562	rod shape-determining protein MreB; Provisional; Region: PRK13927
568206012563	MreB and similar proteins; Region: MreB_like; cd10225
568206012564	nucleotide binding site [chemical binding]; other site
568206012565	Mg binding site [ion binding]; other site
568206012566	putative protofilament interaction site [polypeptide binding]; other site
568206012567	RodZ interaction site [polypeptide binding]; other site
568206012568	hypothetical protein; Reviewed; Region: PRK00024
568206012569	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
568206012570	MPN+ (JAMM) motif; other site
568206012571	Zinc-binding site [ion binding]; other site
568206012572	Maf-like protein; Region: Maf; pfam02545
568206012573	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
568206012574	active site
568206012575	dimer interface [polypeptide binding]; other site
568206012576	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
568206012577	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568206012578	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568206012579	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
568206012580	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
568206012581	active site
568206012582	HIGH motif; other site
568206012583	nucleotide binding site [chemical binding]; other site
568206012584	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
568206012585	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
568206012586	active site
568206012587	KMSKS motif; other site
568206012588	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
568206012589	tRNA binding surface [nucleotide binding]; other site
568206012590	anticodon binding site; other site
568206012591	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
568206012592	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
568206012593	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
568206012594	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568206012595	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
568206012596	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568206012597	inhibitor-cofactor binding pocket; inhibition site
568206012598	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206012599	catalytic residue [active]
568206012600	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
568206012601	dimer interface [polypeptide binding]; other site
568206012602	active site
568206012603	Schiff base residues; other site
568206012604	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
568206012605	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
568206012606	active site
568206012607	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
568206012608	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
568206012609	domain interfaces; other site
568206012610	active site
568206012611	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
568206012612	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
568206012613	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
568206012614	tRNA; other site
568206012615	putative tRNA binding site [nucleotide binding]; other site
568206012616	putative NADP binding site [chemical binding]; other site
568206012617	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
568206012618	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568206012619	MarR family; Region: MarR; pfam01047
568206012620	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
568206012621	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
568206012622	G1 box; other site
568206012623	GTP/Mg2+ binding site [chemical binding]; other site
568206012624	Switch I region; other site
568206012625	G2 box; other site
568206012626	G3 box; other site
568206012627	Switch II region; other site
568206012628	G4 box; other site
568206012629	G5 box; other site
568206012630	potential frameshift: common BLAST hit: gi|49187362|ref|YP_030614.1| ATP-dependent protease La 1
568206012631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206012632	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
568206012633	Walker A motif; other site
568206012634	ATP binding site [chemical binding]; other site
568206012635	Walker B motif; other site
568206012636	arginine finger; other site
568206012637	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
568206012638	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
568206012639	Found in ATP-dependent protease La (LON); Region: LON; smart00464
568206012640	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
568206012641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206012642	Walker A motif; other site
568206012643	ATP binding site [chemical binding]; other site
568206012644	Walker B motif; other site
568206012645	arginine finger; other site
568206012646	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
568206012647	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
568206012648	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
568206012649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206012650	Walker A motif; other site
568206012651	ATP binding site [chemical binding]; other site
568206012652	Walker B motif; other site
568206012653	arginine finger; other site
568206012654	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
568206012655	trigger factor; Provisional; Region: tig; PRK01490
568206012656	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
568206012657	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
568206012658	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
568206012659	pentamer interface [polypeptide binding]; other site
568206012660	dodecaamer interface [polypeptide binding]; other site
568206012661	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
568206012662	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
568206012663	active site
568206012664	metal binding site [ion binding]; metal-binding site
568206012665	homotetramer interface [polypeptide binding]; other site
568206012666	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
568206012667	active site
568206012668	dimerization interface [polypeptide binding]; other site
568206012669	ribonuclease PH; Reviewed; Region: rph; PRK00173
568206012670	Ribonuclease PH; Region: RNase_PH_bact; cd11362
568206012671	hexamer interface [polypeptide binding]; other site
568206012672	active site
568206012673	Sporulation and spore germination; Region: Germane; pfam10646
568206012674	Spore germination protein [General function prediction only]; Region: COG5401
568206012675	Sporulation and spore germination; Region: Germane; pfam10646
568206012676	glutamate racemase; Provisional; Region: PRK00865
568206012677	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568206012678	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
568206012679	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
568206012680	potential catalytic triad [active]
568206012681	conserved cys residue [active]
568206012682	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206012683	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206012684	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
568206012685	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
568206012686	potential catalytic triad [active]
568206012687	conserved cys residue [active]
568206012688	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568206012689	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
568206012690	DNA binding residues [nucleotide binding]
568206012691	dimerization interface [polypeptide binding]; other site
568206012692	putative uracil/xanthine transporter; Provisional; Region: PRK11412
568206012693	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206012694	EamA-like transporter family; Region: EamA; pfam00892
568206012695	EamA-like transporter family; Region: EamA; pfam00892
568206012696	putative deaminase; Validated; Region: PRK06846
568206012697	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
568206012698	active site
568206012699	putative deaminase; Validated; Region: PRK06846
568206012700	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
568206012701	active site
568206012702	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
568206012703	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
568206012704	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568206012705	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
568206012706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206012707	dimer interface [polypeptide binding]; other site
568206012708	conserved gate region; other site
568206012709	ABC-ATPase subunit interface; other site
568206012710	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568206012711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206012712	dimer interface [polypeptide binding]; other site
568206012713	conserved gate region; other site
568206012714	putative PBP binding loops; other site
568206012715	ABC-ATPase subunit interface; other site
568206012716	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568206012717	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206012718	Walker A/P-loop; other site
568206012719	ATP binding site [chemical binding]; other site
568206012720	Q-loop/lid; other site
568206012721	ABC transporter signature motif; other site
568206012722	Walker B; other site
568206012723	D-loop; other site
568206012724	H-loop/switch region; other site
568206012725	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
568206012726	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
568206012727	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568206012728	Walker A/P-loop; other site
568206012729	ATP binding site [chemical binding]; other site
568206012730	Q-loop/lid; other site
568206012731	ABC transporter signature motif; other site
568206012732	Walker B; other site
568206012733	D-loop; other site
568206012734	H-loop/switch region; other site
568206012735	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
568206012736	Histidine kinase; Region: His_kinase; pfam06580
568206012737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206012738	Response regulator receiver domain; Region: Response_reg; pfam00072
568206012739	active site
568206012740	phosphorylation site [posttranslational modification]
568206012741	intermolecular recognition site; other site
568206012742	dimerization interface [polypeptide binding]; other site
568206012743	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206012744	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568206012745	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568206012746	potential frameshift: common BLAST hit: gi|49478670|ref|YP_038554.1| sodium:solute symporter family permease
568206012747	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
568206012748	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
568206012749	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
568206012750	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206012751	non-specific DNA binding site [nucleotide binding]; other site
568206012752	salt bridge; other site
568206012753	sequence-specific DNA binding site [nucleotide binding]; other site
568206012754	Cupin domain; Region: Cupin_2; pfam07883
568206012755	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
568206012756	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
568206012757	amphipathic channel; other site
568206012758	Asn-Pro-Ala signature motifs; other site
568206012759	Predicted transcriptional regulator [Transcription]; Region: COG1959
568206012760	Transcriptional regulator; Region: Rrf2; pfam02082
568206012761	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
568206012762	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
568206012763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206012764	Walker A/P-loop; other site
568206012765	ATP binding site [chemical binding]; other site
568206012766	Q-loop/lid; other site
568206012767	ABC transporter signature motif; other site
568206012768	Walker B; other site
568206012769	D-loop; other site
568206012770	H-loop/switch region; other site
568206012771	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
568206012772	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206012773	active site
568206012774	motif I; other site
568206012775	motif II; other site
568206012776	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
568206012777	ligand binding site [chemical binding]; other site
568206012778	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
568206012779	flagellar motor protein MotA; Validated; Region: PRK08124
568206012780	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
568206012781	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
568206012782	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
568206012783	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
568206012784	active site
568206012785	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
568206012786	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
568206012787	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
568206012788	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
568206012789	L-aspartate oxidase; Provisional; Region: PRK06175
568206012790	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
568206012791	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
568206012792	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
568206012793	putative Iron-sulfur protein interface [polypeptide binding]; other site
568206012794	proximal heme binding site [chemical binding]; other site
568206012795	distal heme binding site [chemical binding]; other site
568206012796	putative dimer interface [polypeptide binding]; other site
568206012797	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
568206012798	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
568206012799	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
568206012800	GIY-YIG motif/motif A; other site
568206012801	active site
568206012802	catalytic site [active]
568206012803	putative DNA binding site [nucleotide binding]; other site
568206012804	metal binding site [ion binding]; metal-binding site
568206012805	UvrB/uvrC motif; Region: UVR; pfam02151
568206012806	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
568206012807	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568206012808	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
568206012809	catalytic residues [active]
568206012810	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
568206012811	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
568206012812	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
568206012813	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
568206012814	Ligand binding site [chemical binding]; other site
568206012815	Electron transfer flavoprotein domain; Region: ETF; pfam01012
568206012816	enoyl-CoA hydratase; Provisional; Region: PRK07658
568206012817	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
568206012818	substrate binding site [chemical binding]; other site
568206012819	oxyanion hole (OAH) forming residues; other site
568206012820	trimer interface [polypeptide binding]; other site
568206012821	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
568206012822	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206012823	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206012824	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
568206012825	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
568206012826	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
568206012827	acyl-activating enzyme (AAE) consensus motif; other site
568206012828	putative AMP binding site [chemical binding]; other site
568206012829	putative active site [active]
568206012830	putative CoA binding site [chemical binding]; other site
568206012831	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
568206012832	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
568206012833	siderophore binding site; other site
568206012834	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206012835	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206012836	ABC-ATPase subunit  interface; other site
568206012837	dimer interface [polypeptide binding]; other site
568206012838	putative PBP binding regions; other site
568206012839	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206012840	ABC-ATPase subunit  interface; other site
568206012841	dimer interface [polypeptide binding]; other site
568206012842	putative PBP binding regions; other site
568206012843	DinB family; Region: DinB; cl17821
568206012844	DinB superfamily; Region: DinB_2; pfam12867
568206012845	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
568206012846	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
568206012847	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
568206012848	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206012849	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
568206012850	Walker A/P-loop; other site
568206012851	ATP binding site [chemical binding]; other site
568206012852	Q-loop/lid; other site
568206012853	ABC transporter signature motif; other site
568206012854	Walker B; other site
568206012855	D-loop; other site
568206012856	H-loop/switch region; other site
568206012857	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206012858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206012859	dimer interface [polypeptide binding]; other site
568206012860	phosphorylation site [posttranslational modification]
568206012861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206012862	ATP binding site [chemical binding]; other site
568206012863	Mg2+ binding site [ion binding]; other site
568206012864	G-X-G motif; other site
568206012865	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206012866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206012867	active site
568206012868	phosphorylation site [posttranslational modification]
568206012869	intermolecular recognition site; other site
568206012870	dimerization interface [polypeptide binding]; other site
568206012871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206012872	DNA binding site [nucleotide binding]
568206012873	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
568206012874	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
568206012875	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
568206012876	putative RNA binding site [nucleotide binding]; other site
568206012877	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
568206012878	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
568206012879	TrkA-N domain; Region: TrkA_N; pfam02254
568206012880	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314
568206012881	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
568206012882	active site
568206012883	catalytic site [active]
568206012884	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568206012885	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568206012886	Walker A/P-loop; other site
568206012887	ATP binding site [chemical binding]; other site
568206012888	Q-loop/lid; other site
568206012889	ABC transporter signature motif; other site
568206012890	Walker B; other site
568206012891	D-loop; other site
568206012892	H-loop/switch region; other site
568206012893	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
568206012894	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206012895	ABC-ATPase subunit  interface; other site
568206012896	dimer interface [polypeptide binding]; other site
568206012897	putative PBP binding regions; other site
568206012898	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
568206012899	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
568206012900	intersubunit interface [polypeptide binding]; other site
568206012901	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206012902	heme-binding site [chemical binding]; other site
568206012903	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206012904	heme-binding site [chemical binding]; other site
568206012905	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206012906	heme-binding site [chemical binding]; other site
568206012907	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206012908	heme-binding site [chemical binding]; other site
568206012909	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206012910	heme-binding site [chemical binding]; other site
568206012911	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206012912	heme-binding site [chemical binding]; other site
568206012913	heme uptake protein IsdC; Region: IsdC; TIGR03656
568206012914	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568206012915	heme-binding site [chemical binding]; other site
568206012916	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
568206012917	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
568206012918	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
568206012919	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206012920	RNA binding surface [nucleotide binding]; other site
568206012921	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
568206012922	probable active site [active]
568206012923	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
568206012924	MutS domain III; Region: MutS_III; pfam05192
568206012925	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
568206012926	Walker A/P-loop; other site
568206012927	ATP binding site [chemical binding]; other site
568206012928	Q-loop/lid; other site
568206012929	ABC transporter signature motif; other site
568206012930	Walker B; other site
568206012931	D-loop; other site
568206012932	H-loop/switch region; other site
568206012933	Smr domain; Region: Smr; pfam01713
568206012934	hypothetical protein; Provisional; Region: PRK08609
568206012935	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
568206012936	active site
568206012937	primer binding site [nucleotide binding]; other site
568206012938	NTP  binding site [chemical binding]; other site
568206012939	metal binding triad [ion binding]; metal-binding site
568206012940	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
568206012941	active site
568206012942	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
568206012943	Colicin V production protein; Region: Colicin_V; pfam02674
568206012944	cell division protein ZapA; Provisional; Region: PRK14126
568206012945	ribonuclease HIII; Provisional; Region: PRK00996
568206012946	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
568206012947	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
568206012948	RNA/DNA hybrid binding site [nucleotide binding]; other site
568206012949	active site
568206012950	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
568206012951	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
568206012952	putative dimer interface [polypeptide binding]; other site
568206012953	putative anticodon binding site; other site
568206012954	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
568206012955	homodimer interface [polypeptide binding]; other site
568206012956	motif 1; other site
568206012957	motif 2; other site
568206012958	active site
568206012959	motif 3; other site
568206012960	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
568206012961	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
568206012962	putative tRNA-binding site [nucleotide binding]; other site
568206012963	B3/4 domain; Region: B3_4; pfam03483
568206012964	tRNA synthetase B5 domain; Region: B5; smart00874
568206012965	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
568206012966	dimer interface [polypeptide binding]; other site
568206012967	motif 1; other site
568206012968	motif 3; other site
568206012969	motif 2; other site
568206012970	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
568206012971	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
568206012972	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
568206012973	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
568206012974	dimer interface [polypeptide binding]; other site
568206012975	motif 1; other site
568206012976	active site
568206012977	motif 2; other site
568206012978	motif 3; other site
568206012979	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
568206012980	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
568206012981	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
568206012982	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
568206012983	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206012984	Zn2+ binding site [ion binding]; other site
568206012985	Mg2+ binding site [ion binding]; other site
568206012986	CAAX protease self-immunity; Region: Abi; pfam02517
568206012987	CAAX protease self-immunity; Region: Abi; pfam02517
568206012988	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568206012989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206012990	putative substrate translocation pore; other site
568206012991	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206012992	HlyD family secretion protein; Region: HlyD_3; pfam13437
568206012993	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206012994	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206012995	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
568206012996	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568206012997	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
568206012998	oligomer interface [polypeptide binding]; other site
568206012999	active site
568206013000	metal binding site [ion binding]; metal-binding site
568206013001	dUTPase; Region: dUTPase_2; pfam08761
568206013002	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
568206013003	active site
568206013004	homodimer interface [polypeptide binding]; other site
568206013005	metal binding site [ion binding]; metal-binding site
568206013006	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
568206013007	23S rRNA binding site [nucleotide binding]; other site
568206013008	L21 binding site [polypeptide binding]; other site
568206013009	L13 binding site [polypeptide binding]; other site
568206013010	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
568206013011	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
568206013012	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
568206013013	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
568206013014	Ribosomal protein L20 leader
568206013015	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
568206013016	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
568206013017	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
568206013018	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
568206013019	active site
568206013020	dimer interface [polypeptide binding]; other site
568206013021	motif 1; other site
568206013022	motif 2; other site
568206013023	motif 3; other site
568206013024	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
568206013025	anticodon binding site; other site
568206013026	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
568206013027	primosomal protein DnaI; Reviewed; Region: PRK08939
568206013028	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
568206013029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206013030	Walker A motif; other site
568206013031	ATP binding site [chemical binding]; other site
568206013032	Walker B motif; other site
568206013033	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
568206013034	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
568206013035	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
568206013036	ATP cone domain; Region: ATP-cone; pfam03477
568206013037	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
568206013038	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
568206013039	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
568206013040	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
568206013041	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
568206013042	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
568206013043	CoA-binding site [chemical binding]; other site
568206013044	ATP-binding [chemical binding]; other site
568206013045	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
568206013046	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
568206013047	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
568206013048	DNA binding site [nucleotide binding]
568206013049	catalytic residue [active]
568206013050	H2TH interface [polypeptide binding]; other site
568206013051	putative catalytic residues [active]
568206013052	turnover-facilitating residue; other site
568206013053	intercalation triad [nucleotide binding]; other site
568206013054	8OG recognition residue [nucleotide binding]; other site
568206013055	putative reading head residues; other site
568206013056	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
568206013057	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
568206013058	DNA polymerase I; Provisional; Region: PRK05755
568206013059	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
568206013060	active site
568206013061	metal binding site 1 [ion binding]; metal-binding site
568206013062	putative 5' ssDNA interaction site; other site
568206013063	metal binding site 3; metal-binding site
568206013064	metal binding site 2 [ion binding]; metal-binding site
568206013065	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
568206013066	putative DNA binding site [nucleotide binding]; other site
568206013067	putative metal binding site [ion binding]; other site
568206013068	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
568206013069	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
568206013070	active site
568206013071	DNA binding site [nucleotide binding]
568206013072	catalytic site [active]
568206013073	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206013074	dimerization interface [polypeptide binding]; other site
568206013075	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
568206013076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206013077	putative active site [active]
568206013078	heme pocket [chemical binding]; other site
568206013079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206013080	dimer interface [polypeptide binding]; other site
568206013081	phosphorylation site [posttranslational modification]
568206013082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206013083	ATP binding site [chemical binding]; other site
568206013084	Mg2+ binding site [ion binding]; other site
568206013085	G-X-G motif; other site
568206013086	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206013087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206013088	active site
568206013089	phosphorylation site [posttranslational modification]
568206013090	intermolecular recognition site; other site
568206013091	dimerization interface [polypeptide binding]; other site
568206013092	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206013093	DNA binding site [nucleotide binding]
568206013094	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
568206013095	active site 2 [active]
568206013096	active site 1 [active]
568206013097	malate dehydrogenase; Reviewed; Region: PRK06223
568206013098	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
568206013099	NAD(P) binding site [chemical binding]; other site
568206013100	dimer interface [polypeptide binding]; other site
568206013101	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568206013102	substrate binding site [chemical binding]; other site
568206013103	isocitrate dehydrogenase; Reviewed; Region: PRK07006
568206013104	isocitrate dehydrogenase; Validated; Region: PRK07362
568206013105	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
568206013106	dimer interface [polypeptide binding]; other site
568206013107	Citrate synthase; Region: Citrate_synt; pfam00285
568206013108	active site
568206013109	citrylCoA binding site [chemical binding]; other site
568206013110	oxalacetate/citrate binding site [chemical binding]; other site
568206013111	coenzyme A binding site [chemical binding]; other site
568206013112	catalytic triad [active]
568206013113	Protein of unknown function (DUF441); Region: DUF441; pfam04284
568206013114	sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872
568206013115	Domain of unknown function DUF20; Region: UPF0118; pfam01594
568206013116	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
568206013117	pyruvate kinase; Provisional; Region: PRK06354
568206013118	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
568206013119	domain interfaces; other site
568206013120	active site
568206013121	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
568206013122	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
568206013123	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
568206013124	active site
568206013125	ADP/pyrophosphate binding site [chemical binding]; other site
568206013126	dimerization interface [polypeptide binding]; other site
568206013127	allosteric effector site; other site
568206013128	fructose-1,6-bisphosphate binding site; other site
568206013129	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
568206013130	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
568206013131	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
568206013132	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
568206013133	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
568206013134	Transcriptional regulators [Transcription]; Region: FadR; COG2186
568206013135	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206013136	DNA-binding site [nucleotide binding]; DNA binding site
568206013137	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
568206013138	Malic enzyme, N-terminal domain; Region: malic; pfam00390
568206013139	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
568206013140	putative NAD(P) binding site [chemical binding]; other site
568206013141	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
568206013142	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
568206013143	active site
568206013144	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
568206013145	generic binding surface II; other site
568206013146	generic binding surface I; other site
568206013147	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
568206013148	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
568206013149	DHH family; Region: DHH; pfam01368
568206013150	DHHA1 domain; Region: DHHA1; pfam02272
568206013151	YtpI-like protein; Region: YtpI; pfam14007
568206013152	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
568206013153	DRTGG domain; Region: DRTGG; pfam07085
568206013154	FOG: CBS domain [General function prediction only]; Region: COG0517
568206013155	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
568206013156	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
568206013157	active site 2 [active]
568206013158	active site 1 [active]
568206013159	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206013160	DNA-binding site [nucleotide binding]; DNA binding site
568206013161	DRTGG domain; Region: DRTGG; pfam07085
568206013162	metal-dependent hydrolase; Provisional; Region: PRK00685
568206013163	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
568206013164	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
568206013165	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
568206013166	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
568206013167	active site
568206013168	Protein of unknown function (DUF3221); Region: DUF3221; pfam11518
568206013169	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
568206013170	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568206013171	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206013172	Coenzyme A binding pocket [chemical binding]; other site
568206013173	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568206013174	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206013175	Coenzyme A binding pocket [chemical binding]; other site
568206013176	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
568206013177	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206013178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206013179	non-specific DNA binding site [nucleotide binding]; other site
568206013180	salt bridge; other site
568206013181	sequence-specific DNA binding site [nucleotide binding]; other site
568206013182	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
568206013183	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
568206013184	hexamer interface [polypeptide binding]; other site
568206013185	ligand binding site [chemical binding]; other site
568206013186	putative active site [active]
568206013187	NAD(P) binding site [chemical binding]; other site
568206013188	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
568206013189	classical (c) SDRs; Region: SDR_c; cd05233
568206013190	NAD(P) binding site [chemical binding]; other site
568206013191	active site
568206013192	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
568206013193	Ligand Binding Site [chemical binding]; other site
568206013194	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
568206013195	argininosuccinate lyase; Provisional; Region: PRK00855
568206013196	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
568206013197	active sites [active]
568206013198	tetramer interface [polypeptide binding]; other site
568206013199	argininosuccinate synthase; Provisional; Region: PRK13820
568206013200	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
568206013201	ANP binding site [chemical binding]; other site
568206013202	Substrate Binding Site II [chemical binding]; other site
568206013203	Substrate Binding Site I [chemical binding]; other site
568206013204	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206013205	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206013206	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206013207	EcsC protein family; Region: EcsC; pfam12787
568206013208	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
568206013209	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
568206013210	nudix motif; other site
568206013211	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
568206013212	propionate/acetate kinase; Provisional; Region: PRK12379
568206013213	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
568206013214	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206013215	S-adenosylmethionine binding site [chemical binding]; other site
568206013216	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
568206013217	dimer interface [polypeptide binding]; other site
568206013218	catalytic triad [active]
568206013219	peroxidatic and resolving cysteines [active]
568206013220	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
568206013221	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
568206013222	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
568206013223	ATP-NAD kinase; Region: NAD_kinase; pfam01513
568206013224	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
568206013225	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
568206013226	active site
568206013227	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206013228	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568206013229	dimer interface [polypeptide binding]; other site
568206013230	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
568206013231	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
568206013232	active site
568206013233	acyl-activating enzyme (AAE) consensus motif; other site
568206013234	putative CoA binding site [chemical binding]; other site
568206013235	AMP binding site [chemical binding]; other site
568206013236	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
568206013237	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
568206013238	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
568206013239	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
568206013240	Ligand Binding Site [chemical binding]; other site
568206013241	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
568206013242	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
568206013243	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206013244	catalytic residue [active]
568206013245	septation ring formation regulator EzrA; Provisional; Region: PRK04778
568206013246	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206013247	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206013248	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568206013249	dimerization interface [polypeptide binding]; other site
568206013250	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206013251	EamA-like transporter family; Region: EamA; pfam00892
568206013252	EamA-like transporter family; Region: EamA; pfam00892
568206013253	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206013254	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206013255	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
568206013256	GAF domain; Region: GAF_2; pfam13185
568206013257	methionine gamma-lyase; Provisional; Region: PRK06767
568206013258	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568206013259	homodimer interface [polypeptide binding]; other site
568206013260	substrate-cofactor binding pocket; other site
568206013261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206013262	catalytic residue [active]
568206013263	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
568206013264	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
568206013265	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206013266	RNA binding surface [nucleotide binding]; other site
568206013267	Domain of unknown function (DUF4306); Region: DUF4306; pfam14154
568206013268	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
568206013269	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
568206013270	active site
568206013271	HIGH motif; other site
568206013272	dimer interface [polypeptide binding]; other site
568206013273	KMSKS motif; other site
568206013274	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206013275	RNA binding surface [nucleotide binding]; other site
568206013276	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
568206013277	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206013278	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206013279	DNA binding residues [nucleotide binding]
568206013280	acetyl-CoA synthetase; Provisional; Region: PRK04319
568206013281	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
568206013282	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
568206013283	active site
568206013284	acyl-activating enzyme (AAE) consensus motif; other site
568206013285	putative CoA binding site [chemical binding]; other site
568206013286	AMP binding site [chemical binding]; other site
568206013287	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206013288	Coenzyme A binding pocket [chemical binding]; other site
568206013289	FOG: CBS domain [General function prediction only]; Region: COG0517
568206013290	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
568206013291	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
568206013292	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
568206013293	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
568206013294	active site
568206013295	Zn binding site [ion binding]; other site
568206013296	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206013297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206013298	active site
568206013299	phosphorylation site [posttranslational modification]
568206013300	intermolecular recognition site; other site
568206013301	dimerization interface [polypeptide binding]; other site
568206013302	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206013303	DNA binding site [nucleotide binding]
568206013304	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206013305	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206013306	dimerization interface [polypeptide binding]; other site
568206013307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206013308	dimer interface [polypeptide binding]; other site
568206013309	phosphorylation site [posttranslational modification]
568206013310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206013311	ATP binding site [chemical binding]; other site
568206013312	Mg2+ binding site [ion binding]; other site
568206013313	G-X-G motif; other site
568206013314	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
568206013315	Ankyrin repeat; Region: Ank; pfam00023
568206013316	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
568206013317	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
568206013318	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
568206013319	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568206013320	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568206013321	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
568206013322	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
568206013323	Protein of unknown function (DUF3917); Region: DUF3917; pfam13055
568206013324	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
568206013325	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
568206013326	catabolite control protein A; Region: ccpA; TIGR01481
568206013327	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206013328	DNA binding site [nucleotide binding]
568206013329	domain linker motif; other site
568206013330	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
568206013331	dimerization interface [polypeptide binding]; other site
568206013332	effector binding site; other site
568206013333	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
568206013334	putative dimer interface [polypeptide binding]; other site
568206013335	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
568206013336	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
568206013337	putative dimer interface [polypeptide binding]; other site
568206013338	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
568206013339	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
568206013340	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
568206013341	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
568206013342	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
568206013343	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206013344	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206013345	Coenzyme A binding pocket [chemical binding]; other site
568206013346	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
568206013347	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568206013348	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568206013349	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568206013350	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
568206013351	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
568206013352	active site
568206013353	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
568206013354	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568206013355	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
568206013356	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
568206013357	putative tRNA-binding site [nucleotide binding]; other site
568206013358	hypothetical protein; Provisional; Region: PRK13668
568206013359	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568206013360	catalytic residues [active]
568206013361	NTPase; Reviewed; Region: PRK03114
568206013362	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568206013363	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
568206013364	oligomer interface [polypeptide binding]; other site
568206013365	active site
568206013366	metal binding site [ion binding]; metal-binding site
568206013367	Predicted small secreted protein [Function unknown]; Region: COG5584
568206013368	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206013369	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206013370	S-adenosylmethionine binding site [chemical binding]; other site
568206013371	YtzH-like protein; Region: YtzH; pfam14165
568206013372	Phosphotransferase enzyme family; Region: APH; pfam01636
568206013373	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
568206013374	active site
568206013375	substrate binding site [chemical binding]; other site
568206013376	ATP binding site [chemical binding]; other site
568206013377	pullulanase, type I; Region: pulA_typeI; TIGR02104
568206013378	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
568206013379	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
568206013380	Ca binding site [ion binding]; other site
568206013381	active site
568206013382	catalytic site [active]
568206013383	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
568206013384	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
568206013385	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
568206013386	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
568206013387	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
568206013388	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
568206013389	active site
568206013390	metal binding site [ion binding]; metal-binding site
568206013391	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
568206013392	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
568206013393	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206013394	RNA binding surface [nucleotide binding]; other site
568206013395	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
568206013396	active site
568206013397	uracil binding [chemical binding]; other site
568206013398	stage V sporulation protein B; Region: spore_V_B; TIGR02900
568206013399	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568206013400	HI0933-like protein; Region: HI0933_like; pfam03486
568206013401	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206013402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206013403	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568206013404	putative substrate translocation pore; other site
568206013405	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206013406	dimerization interface [polypeptide binding]; other site
568206013407	putative DNA binding site [nucleotide binding]; other site
568206013408	putative Zn2+ binding site [ion binding]; other site
568206013409	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
568206013410	putative hydrophobic ligand binding site [chemical binding]; other site
568206013411	Domain of unknown function (DUF3973); Region: DUF3973; pfam13119
568206013412	Protein of unknown function (DUF2758); Region: DUF2758; pfam10957
568206013413	Protein of unknown function (DUF2553); Region: DUF2553; pfam10830
568206013414	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
568206013415	glucose-1-dehydrogenase; Provisional; Region: PRK08936
568206013416	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
568206013417	NAD binding site [chemical binding]; other site
568206013418	homodimer interface [polypeptide binding]; other site
568206013419	active site
568206013420	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
568206013421	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
568206013422	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
568206013423	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
568206013424	MoaE interaction surface [polypeptide binding]; other site
568206013425	MoeB interaction surface [polypeptide binding]; other site
568206013426	thiocarboxylated glycine; other site
568206013427	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
568206013428	MoaE homodimer interface [polypeptide binding]; other site
568206013429	MoaD interaction [polypeptide binding]; other site
568206013430	active site residues [active]
568206013431	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
568206013432	Walker A motif; other site
568206013433	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
568206013434	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
568206013435	dimer interface [polypeptide binding]; other site
568206013436	putative functional site; other site
568206013437	putative MPT binding site; other site
568206013438	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
568206013439	trimer interface [polypeptide binding]; other site
568206013440	dimer interface [polypeptide binding]; other site
568206013441	putative active site [active]
568206013442	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
568206013443	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
568206013444	ATP binding site [chemical binding]; other site
568206013445	substrate interface [chemical binding]; other site
568206013446	potential frameshift: common BLAST hit: gi|49478739|ref|YP_038771.1| molybdenum cofactor biosynthesis protein A
568206013447	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
568206013448	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206013449	FeS/SAM binding site; other site
568206013450	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
568206013451	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568206013452	active site residue [active]
568206013453	homoserine O-acetyltransferase; Provisional; Region: PRK06765
568206013454	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
568206013455	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
568206013456	Spore germination protein; Region: Spore_permease; pfam03845
568206013457	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
568206013458	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
568206013459	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
568206013460	putative nucleotide binding site [chemical binding]; other site
568206013461	putative metal binding site [ion binding]; other site
568206013462	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
568206013463	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
568206013464	HIGH motif; other site
568206013465	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
568206013466	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
568206013467	active site
568206013468	KMSKS motif; other site
568206013469	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
568206013470	tRNA binding surface [nucleotide binding]; other site
568206013471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206013472	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206013473	putative substrate translocation pore; other site
568206013474	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
568206013475	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
568206013476	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
568206013477	TrkA-C domain; Region: TrkA_C; pfam02080
568206013478	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
568206013479	Int/Topo IB signature motif; other site
568206013480	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206013481	FtsX-like permease family; Region: FtsX; pfam02687
568206013482	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206013483	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206013484	Walker A/P-loop; other site
568206013485	ATP binding site [chemical binding]; other site
568206013486	Q-loop/lid; other site
568206013487	ABC transporter signature motif; other site
568206013488	Walker B; other site
568206013489	D-loop; other site
568206013490	H-loop/switch region; other site
568206013491	Protein of unknown function (DUF418); Region: DUF418; cl12135
568206013492	Protein of unknown function (DUF418); Region: DUF418; pfam04235
568206013493	Protein of unknown function (DUF2524); Region: DUF2524; pfam10732
568206013494	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
568206013495	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206013496	FeS/SAM binding site; other site
568206013497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206013498	S-adenosylmethionine binding site [chemical binding]; other site
568206013499	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206013500	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206013501	Walker A/P-loop; other site
568206013502	ATP binding site [chemical binding]; other site
568206013503	Q-loop/lid; other site
568206013504	ABC transporter signature motif; other site
568206013505	Walker B; other site
568206013506	D-loop; other site
568206013507	H-loop/switch region; other site
568206013508	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
568206013509	aspartate racemase; Region: asp_race; TIGR00035
568206013510	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
568206013511	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
568206013512	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
568206013513	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
568206013514	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568206013515	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206013516	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
568206013517	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
568206013518	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
568206013519	trimer interface [polypeptide binding]; other site
568206013520	putative metal binding site [ion binding]; other site
568206013521	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
568206013522	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
568206013523	active site
568206013524	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206013525	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
568206013526	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
568206013527	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
568206013528	GTP binding site; other site
568206013529	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
568206013530	MPT binding site; other site
568206013531	trimer interface [polypeptide binding]; other site
568206013532	S-adenosylmethionine synthetase; Validated; Region: PRK05250
568206013533	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
568206013534	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
568206013535	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
568206013536	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
568206013537	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
568206013538	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
568206013539	active site
568206013540	substrate-binding site [chemical binding]; other site
568206013541	metal-binding site [ion binding]
568206013542	ATP binding site [chemical binding]; other site
568206013543	ATP synthase I chain; Region: ATP_synt_I; pfam03899
568206013544	EamA-like transporter family; Region: EamA; pfam00892
568206013545	EamA-like transporter family; Region: EamA; pfam00892
568206013546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
568206013547	Uncharacterized conserved protein [Function unknown]; Region: COG0327
568206013548	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
568206013549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206013550	ATP binding site [chemical binding]; other site
568206013551	Mg2+ binding site [ion binding]; other site
568206013552	G-X-G motif; other site
568206013553	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206013554	dimer interface [polypeptide binding]; other site
568206013555	phosphorylation site [posttranslational modification]
568206013556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206013557	ATP binding site [chemical binding]; other site
568206013558	Mg2+ binding site [ion binding]; other site
568206013559	G-X-G motif; other site
568206013560	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568206013561	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568206013562	potential frameshift: common BLAST hit: gi|52140724|ref|YP_086106.1| phosphoglycerol transferase
568206013563	Sulfatase; Region: Sulfatase; pfam00884
568206013564	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
568206013565	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
568206013566	NMT1-like family; Region: NMT1_2; pfam13379
568206013567	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
568206013568	Walker A/P-loop; other site
568206013569	ATP binding site [chemical binding]; other site
568206013570	ABC transporter; Region: ABC_tran; pfam00005
568206013571	Q-loop/lid; other site
568206013572	ABC transporter signature motif; other site
568206013573	Walker B; other site
568206013574	D-loop; other site
568206013575	H-loop/switch region; other site
568206013576	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
568206013577	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206013578	dimer interface [polypeptide binding]; other site
568206013579	conserved gate region; other site
568206013580	putative PBP binding loops; other site
568206013581	ABC-ATPase subunit interface; other site
568206013582	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
568206013583	active site
568206013584	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
568206013585	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206013586	motif II; other site
568206013587	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
568206013588	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
568206013589	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
568206013590	nudix motif; other site
568206013591	Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606
568206013592	S-ribosylhomocysteinase; Provisional; Region: PRK02260
568206013593	Haemolytic domain; Region: Haemolytic; pfam01809
568206013594	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
568206013595	active site clefts [active]
568206013596	zinc binding site [ion binding]; other site
568206013597	dimer interface [polypeptide binding]; other site
568206013598	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
568206013599	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
568206013600	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
568206013601	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
568206013602	S-layer homology domain; Region: SLH; pfam00395
568206013603	S-layer homology domain; Region: SLH; pfam00395
568206013604	S-layer homology domain; Region: SLH; pfam00395
568206013605	Excalibur calcium-binding domain; Region: Excalibur; smart00894
568206013606	Uncharacterized conserved protein [Function unknown]; Region: COG1434
568206013607	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568206013608	putative active site [active]
568206013609	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206013610	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206013611	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206013612	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206013613	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
568206013614	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
568206013615	Predicted membrane protein [Function unknown]; Region: COG3766
568206013616	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
568206013617	hypothetical protein; Provisional; Region: PRK12473
568206013618	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
568206013619	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
568206013620	G1 box; other site
568206013621	GTP/Mg2+ binding site [chemical binding]; other site
568206013622	Switch I region; other site
568206013623	G2 box; other site
568206013624	G3 box; other site
568206013625	Switch II region; other site
568206013626	G4 box; other site
568206013627	G5 box; other site
568206013628	Nucleoside recognition; Region: Gate; pfam07670
568206013629	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
568206013630	Nucleoside recognition; Region: Gate; pfam07670
568206013631	FeoA domain; Region: FeoA; pfam04023
568206013632	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
568206013633	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206013634	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206013635	dimerization interface [polypeptide binding]; other site
568206013636	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206013637	dimer interface [polypeptide binding]; other site
568206013638	phosphorylation site [posttranslational modification]
568206013639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206013640	ATP binding site [chemical binding]; other site
568206013641	Mg2+ binding site [ion binding]; other site
568206013642	G-X-G motif; other site
568206013643	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206013644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206013645	active site
568206013646	phosphorylation site [posttranslational modification]
568206013647	intermolecular recognition site; other site
568206013648	dimerization interface [polypeptide binding]; other site
568206013649	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206013650	DNA binding site [nucleotide binding]
568206013651	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
568206013652	active site
568206013653	catalytic site [active]
568206013654	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206013655	active site
568206013656	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
568206013657	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
568206013658	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
568206013659	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
568206013660	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
568206013661	putative hydrophobic ligand binding site [chemical binding]; other site
568206013662	protein interface [polypeptide binding]; other site
568206013663	gate; other site
568206013664	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206013665	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206013666	active site
568206013667	catalytic tetrad [active]
568206013668	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
568206013669	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
568206013670	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568206013671	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206013672	S-adenosylmethionine binding site [chemical binding]; other site
568206013673	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206013674	FtsX-like permease family; Region: FtsX; pfam02687
568206013675	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206013676	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206013677	Walker A/P-loop; other site
568206013678	ATP binding site [chemical binding]; other site
568206013679	Q-loop/lid; other site
568206013680	ABC transporter signature motif; other site
568206013681	Walker B; other site
568206013682	D-loop; other site
568206013683	H-loop/switch region; other site
568206013684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
568206013685	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206013686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206013687	active site
568206013688	phosphorylation site [posttranslational modification]
568206013689	intermolecular recognition site; other site
568206013690	dimerization interface [polypeptide binding]; other site
568206013691	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206013692	DNA binding site [nucleotide binding]
568206013693	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206013694	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
568206013695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206013696	ATP binding site [chemical binding]; other site
568206013697	Mg2+ binding site [ion binding]; other site
568206013698	G-X-G motif; other site
568206013699	FtsX-like permease family; Region: FtsX; pfam02687
568206013700	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206013701	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206013702	Walker A/P-loop; other site
568206013703	ATP binding site [chemical binding]; other site
568206013704	Q-loop/lid; other site
568206013705	ABC transporter signature motif; other site
568206013706	Walker B; other site
568206013707	D-loop; other site
568206013708	H-loop/switch region; other site
568206013709	potential frameshift: common BLAST hit: gi|52140663|ref|YP_086167.1| ABC transporter, permease
568206013710	GntP family permease; Region: GntP_permease; pfam02447
568206013711	fructuronate transporter; Provisional; Region: PRK10034; cl15264
568206013712	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568206013713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568206013714	DNA-binding site [nucleotide binding]; DNA binding site
568206013715	UTRA domain; Region: UTRA; pfam07702
568206013716	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
568206013717	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
568206013718	substrate binding site [chemical binding]; other site
568206013719	ATP binding site [chemical binding]; other site
568206013720	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
568206013721	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
568206013722	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206013723	catalytic residue [active]
568206013724	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
568206013725	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
568206013726	active site
568206013727	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
568206013728	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
568206013729	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
568206013730	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206013731	dimerization interface [polypeptide binding]; other site
568206013732	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206013733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206013734	dimer interface [polypeptide binding]; other site
568206013735	phosphorylation site [posttranslational modification]
568206013736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206013737	ATP binding site [chemical binding]; other site
568206013738	Mg2+ binding site [ion binding]; other site
568206013739	G-X-G motif; other site
568206013740	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206013741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206013742	active site
568206013743	phosphorylation site [posttranslational modification]
568206013744	intermolecular recognition site; other site
568206013745	dimerization interface [polypeptide binding]; other site
568206013746	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206013747	DNA binding site [nucleotide binding]
568206013748	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
568206013749	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
568206013750	active site
568206013751	octamer interface [polypeptide binding]; other site
568206013752	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
568206013753	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
568206013754	acyl-activating enzyme (AAE) consensus motif; other site
568206013755	putative AMP binding site [chemical binding]; other site
568206013756	putative active site [active]
568206013757	putative CoA binding site [chemical binding]; other site
568206013758	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
568206013759	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
568206013760	substrate binding site [chemical binding]; other site
568206013761	oxyanion hole (OAH) forming residues; other site
568206013762	trimer interface [polypeptide binding]; other site
568206013763	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
568206013764	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
568206013765	nucleophilic elbow; other site
568206013766	catalytic triad; other site
568206013767	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
568206013768	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
568206013769	dimer interface [polypeptide binding]; other site
568206013770	tetramer interface [polypeptide binding]; other site
568206013771	PYR/PP interface [polypeptide binding]; other site
568206013772	TPP binding site [chemical binding]; other site
568206013773	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
568206013774	TPP-binding site; other site
568206013775	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
568206013776	chorismate binding enzyme; Region: Chorismate_bind; cl10555
568206013777	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
568206013778	UbiA prenyltransferase family; Region: UbiA; pfam01040
568206013779	regulatory protein, yteA family; Region: bacill_yteA; TIGR02890
568206013780	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568206013781	DNA-binding site [nucleotide binding]; DNA binding site
568206013782	RNA-binding motif; other site
568206013783	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
568206013784	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
568206013785	active site flap/lid [active]
568206013786	nucleophilic elbow; other site
568206013787	catalytic triad [active]
568206013788	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
568206013789	homodimer interface [polypeptide binding]; other site
568206013790	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
568206013791	active site pocket [active]
568206013792	glycogen synthase; Provisional; Region: glgA; PRK00654
568206013793	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
568206013794	ADP-binding pocket [chemical binding]; other site
568206013795	homodimer interface [polypeptide binding]; other site
568206013796	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
568206013797	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
568206013798	ligand binding site; other site
568206013799	oligomer interface; other site
568206013800	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
568206013801	dimer interface [polypeptide binding]; other site
568206013802	N-terminal domain interface [polypeptide binding]; other site
568206013803	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
568206013804	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
568206013805	ligand binding site; other site
568206013806	oligomer interface; other site
568206013807	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
568206013808	dimer interface [polypeptide binding]; other site
568206013809	N-terminal domain interface [polypeptide binding]; other site
568206013810	sulfate 1 binding site; other site
568206013811	glycogen branching enzyme; Provisional; Region: PRK12313
568206013812	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
568206013813	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
568206013814	active site
568206013815	catalytic site [active]
568206013816	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
568206013817	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
568206013818	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568206013819	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568206013820	NAD binding site [chemical binding]; other site
568206013821	dimer interface [polypeptide binding]; other site
568206013822	substrate binding site [chemical binding]; other site
568206013823	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
568206013824	MgtC family; Region: MgtC; pfam02308
568206013825	Ion channel; Region: Ion_trans_2; pfam07885
568206013826	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
568206013827	TrkA-N domain; Region: TrkA_N; pfam02254
568206013828	YugN-like family; Region: YugN; pfam08868
568206013829	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
568206013830	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
568206013831	active site
568206013832	dimer interface [polypeptide binding]; other site
568206013833	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
568206013834	dimer interface [polypeptide binding]; other site
568206013835	active site
568206013836	Domain of unknown function (DUF378); Region: DUF378; pfam04070
568206013837	general stress protein 13; Validated; Region: PRK08059
568206013838	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
568206013839	RNA binding site [nucleotide binding]; other site
568206013840	hypothetical protein; Validated; Region: PRK07682
568206013841	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206013842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206013843	homodimer interface [polypeptide binding]; other site
568206013844	catalytic residue [active]
568206013845	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
568206013846	AsnC family; Region: AsnC_trans_reg; pfam01037
568206013847	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
568206013848	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
568206013849	dimerization interface [polypeptide binding]; other site
568206013850	ligand binding site [chemical binding]; other site
568206013851	NADP binding site [chemical binding]; other site
568206013852	catalytic site [active]
568206013853	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
568206013854	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568206013855	nucleophilic elbow; other site
568206013856	catalytic triad; other site
568206013857	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
568206013858	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
568206013859	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568206013860	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206013861	homodimer interface [polypeptide binding]; other site
568206013862	catalytic residue [active]
568206013863	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
568206013864	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
568206013865	E-class dimer interface [polypeptide binding]; other site
568206013866	P-class dimer interface [polypeptide binding]; other site
568206013867	active site
568206013868	Cu2+ binding site [ion binding]; other site
568206013869	Zn2+ binding site [ion binding]; other site
568206013870	Protein of unknown function (DUF2681); Region: DUF2681; pfam10883
568206013871	Kinase associated protein B; Region: KapB; pfam08810
568206013872	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
568206013873	active site
568206013874	catalytic site [active]
568206013875	substrate binding site [chemical binding]; other site
568206013876	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
568206013877	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
568206013878	transmembrane helices; other site
568206013879	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
568206013880	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
568206013881	active site
568206013882	glycyl-tRNA synthetase; Provisional; Region: PRK04173
568206013883	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
568206013884	motif 1; other site
568206013885	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
568206013886	active site
568206013887	motif 2; other site
568206013888	motif 3; other site
568206013889	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
568206013890	anticodon binding site; other site
568206013891	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
568206013892	CoenzymeA binding site [chemical binding]; other site
568206013893	subunit interaction site [polypeptide binding]; other site
568206013894	PHB binding site; other site
568206013895	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
568206013896	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
568206013897	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
568206013898	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
568206013899	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
568206013900	active site
568206013901	tetramer interface; other site
568206013902	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
568206013903	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
568206013904	active site
568206013905	substrate binding site [chemical binding]; other site
568206013906	metal binding site [ion binding]; metal-binding site
568206013907	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
568206013908	Uncharacterized conserved protein [Function unknown]; Region: COG1624
568206013909	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
568206013910	multifunctional aminopeptidase A; Provisional; Region: PRK00913
568206013911	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
568206013912	interface (dimer of trimers) [polypeptide binding]; other site
568206013913	Substrate-binding/catalytic site; other site
568206013914	Zn-binding sites [ion binding]; other site
568206013915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
568206013916	Putative membrane protein; Region: YuiB; pfam14068
568206013917	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
568206013918	nudix motif; other site
568206013919	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
568206013920	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206013921	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
568206013922	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206013923	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206013924	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
568206013925	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
568206013926	Domain of unknown function DUF11; Region: DUF11; pfam01345
568206013927	Domain of unknown function DUF11; Region: DUF11; pfam01345
568206013928	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
568206013929	Domain of unknown function DUF11; Region: DUF11; pfam01345
568206013930	Domain of unknown function DUF11; Region: DUF11; cl17728
568206013931	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
568206013932	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
568206013933	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
568206013934	H+ Antiporter protein; Region: 2A0121; TIGR00900
568206013935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206013936	putative substrate translocation pore; other site
568206013937	Helix-turn-helix domain; Region: HTH_36; pfam13730
568206013938	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
568206013939	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
568206013940	putative DNA binding site [nucleotide binding]; other site
568206013941	dimerization interface [polypeptide binding]; other site
568206013942	Protein of unknown function (DUF523); Region: DUF523; pfam04463
568206013943	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
568206013944	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
568206013945	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206013946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206013947	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
568206013948	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
568206013949	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
568206013950	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
568206013951	hypothetical protein; Provisional; Region: PRK13669
568206013952	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
568206013953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206013954	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
568206013955	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206013956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206013957	Walker A/P-loop; other site
568206013958	ATP binding site [chemical binding]; other site
568206013959	Q-loop/lid; other site
568206013960	ABC transporter signature motif; other site
568206013961	Walker B; other site
568206013962	D-loop; other site
568206013963	H-loop/switch region; other site
568206013964	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
568206013965	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
568206013966	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
568206013967	PhnA protein; Region: PhnA; pfam03831
568206013968	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
568206013969	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
568206013970	PQQ-like domain; Region: PQQ_2; pfam13360
568206013971	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
568206013972	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
568206013973	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
568206013974	CAAX protease self-immunity; Region: Abi; pfam02517
568206013975	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
568206013976	active site
568206013977	NTP binding site [chemical binding]; other site
568206013978	metal binding triad [ion binding]; metal-binding site
568206013979	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
568206013980	Protein of unknown function (DUF1462); Region: DUF1462; pfam07315
568206013981	NifU-like domain; Region: NifU; pfam01106
568206013982	spore coat protein YutH; Region: spore_yutH; TIGR02905
568206013983	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
568206013984	tetramer interfaces [polypeptide binding]; other site
568206013985	binuclear metal-binding site [ion binding]; other site
568206013986	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
568206013987	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
568206013988	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568206013989	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
568206013990	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206013991	active site
568206013992	motif I; other site
568206013993	motif II; other site
568206013994	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206013995	Predicted transcriptional regulator [Transcription]; Region: COG2345
568206013996	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206013997	putative Zn2+ binding site [ion binding]; other site
568206013998	putative DNA binding site [nucleotide binding]; other site
568206013999	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
568206014000	Uncharacterized conserved protein [Function unknown]; Region: COG2445
568206014001	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
568206014002	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
568206014003	putative active site [active]
568206014004	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
568206014005	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
568206014006	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
568206014007	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
568206014008	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
568206014009	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206014010	DNA binding residues [nucleotide binding]
568206014011	dimer interface [polypeptide binding]; other site
568206014012	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
568206014013	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
568206014014	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568206014015	catalytic core [active]
568206014016	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
568206014017	putative deacylase active site [active]
568206014018	lipoyl synthase; Provisional; Region: PRK05481
568206014019	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206014020	FeS/SAM binding site; other site
568206014021	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206014022	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206014023	sporulation protein YunB; Region: spo_yunB; TIGR02832
568206014024	Uncharacterized conserved protein [Function unknown]; Region: COG3377
568206014025	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
568206014026	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
568206014027	active site
568206014028	metal binding site [ion binding]; metal-binding site
568206014029	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568206014030	Predicted transcriptional regulators [Transcription]; Region: COG1695
568206014031	Transcriptional regulator PadR-like family; Region: PadR; cl17335
568206014032	VanZ like family; Region: VanZ; pfam04892
568206014033	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
568206014034	FeS assembly protein SufB; Region: sufB; TIGR01980
568206014035	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
568206014036	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
568206014037	trimerization site [polypeptide binding]; other site
568206014038	active site
568206014039	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
568206014040	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
568206014041	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568206014042	catalytic residue [active]
568206014043	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
568206014044	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
568206014045	FeS assembly protein SufD; Region: sufD; TIGR01981
568206014046	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
568206014047	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
568206014048	Walker A/P-loop; other site
568206014049	ATP binding site [chemical binding]; other site
568206014050	Q-loop/lid; other site
568206014051	ABC transporter signature motif; other site
568206014052	Walker B; other site
568206014053	D-loop; other site
568206014054	H-loop/switch region; other site
568206014055	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
568206014056	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
568206014057	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
568206014058	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
568206014059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568206014060	ABC-ATPase subunit interface; other site
568206014061	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
568206014062	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
568206014063	Walker A/P-loop; other site
568206014064	ATP binding site [chemical binding]; other site
568206014065	Q-loop/lid; other site
568206014066	ABC transporter signature motif; other site
568206014067	Walker B; other site
568206014068	D-loop; other site
568206014069	H-loop/switch region; other site
568206014070	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
568206014071	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568206014072	catalytic residues [active]
568206014073	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
568206014074	putative active site [active]
568206014075	putative metal binding site [ion binding]; other site
568206014076	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
568206014077	lipoyl attachment site [posttranslational modification]; other site
568206014078	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
568206014079	ArsC family; Region: ArsC; pfam03960
568206014080	putative ArsC-like catalytic residues; other site
568206014081	putative TRX-like catalytic residues [active]
568206014082	Protein of unknown function (DUF3937); Region: DUF3937; pfam13073
568206014083	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
568206014084	active site
568206014085	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
568206014086	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
568206014087	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
568206014088	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568206014089	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568206014090	NAD binding site [chemical binding]; other site
568206014091	dimer interface [polypeptide binding]; other site
568206014092	substrate binding site [chemical binding]; other site
568206014093	Coat F domain; Region: Coat_F; pfam07875
568206014094	CAAX protease self-immunity; Region: Abi; pfam02517
568206014095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206014096	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206014097	WHG domain; Region: WHG; pfam13305
568206014098	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568206014099	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
568206014100	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
568206014101	active site
568206014102	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
568206014103	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
568206014104	dimer interface [polypeptide binding]; other site
568206014105	active site
568206014106	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
568206014107	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
568206014108	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
568206014109	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
568206014110	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
568206014111	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
568206014112	substrate binding site [chemical binding]; other site
568206014113	oxyanion hole (OAH) forming residues; other site
568206014114	YuzL-like protein; Region: YuzL; pfam14115
568206014115	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206014116	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
568206014117	Proline dehydrogenase; Region: Pro_dh; cl03282
568206014118	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
568206014119	Domain of unknown function DUF77; Region: DUF77; pfam01910
568206014120	Cache domain; Region: Cache_1; pfam02743
568206014121	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206014122	dimerization interface [polypeptide binding]; other site
568206014123	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206014124	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206014125	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206014126	dimer interface [polypeptide binding]; other site
568206014127	putative CheW interface [polypeptide binding]; other site
568206014128	Predicted transcriptional regulators [Transcription]; Region: COG1378
568206014129	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
568206014130	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
568206014131	C-terminal domain interface [polypeptide binding]; other site
568206014132	sugar binding site [chemical binding]; other site
568206014133	TQXA domain; Region: TQXA_dom; TIGR03934
568206014134	Cna protein B-type domain; Region: Cna_B; pfam05738
568206014135	Cna protein B-type domain; Region: Cna_B; pfam05738
568206014136	Cna protein B-type domain; Region: Cna_B; pfam05738
568206014137	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568206014138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206014139	putative substrate translocation pore; other site
568206014140	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
568206014141	Spore germination protein; Region: Spore_permease; cl17796
568206014142	MAEBL; Provisional; Region: PTZ00121
568206014143	OxaA-like protein precursor; Validated; Region: PRK01622
568206014144	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568206014145	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568206014146	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568206014147	hypothetical protein; Provisional; Region: PRK06758
568206014148	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
568206014149	active site
568206014150	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206014151	non-specific DNA binding site [nucleotide binding]; other site
568206014152	salt bridge; other site
568206014153	sequence-specific DNA binding site [nucleotide binding]; other site
568206014154	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568206014155	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568206014156	Protein of unknown function (DUF3978); Region: DUF3978; pfam13123
568206014157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
568206014158	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
568206014159	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206014160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206014161	active site
568206014162	phosphorylation site [posttranslational modification]
568206014163	intermolecular recognition site; other site
568206014164	dimerization interface [polypeptide binding]; other site
568206014165	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206014166	DNA binding site [nucleotide binding]
568206014167	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206014168	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206014169	dimer interface [polypeptide binding]; other site
568206014170	phosphorylation site [posttranslational modification]
568206014171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206014172	ATP binding site [chemical binding]; other site
568206014173	Mg2+ binding site [ion binding]; other site
568206014174	G-X-G motif; other site
568206014175	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
568206014176	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
568206014177	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
568206014178	active site
568206014179	HIGH motif; other site
568206014180	KMSKS motif; other site
568206014181	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
568206014182	tRNA binding surface [nucleotide binding]; other site
568206014183	anticodon binding site; other site
568206014184	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568206014185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206014186	S-adenosylmethionine binding site [chemical binding]; other site
568206014187	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206014188	dimerization interface [polypeptide binding]; other site
568206014189	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206014190	dimer interface [polypeptide binding]; other site
568206014191	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206014192	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206014193	dimer interface [polypeptide binding]; other site
568206014194	putative CheW interface [polypeptide binding]; other site
568206014195	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
568206014196	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
568206014197	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
568206014198	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568206014199	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
568206014200	active site
568206014201	Zn binding site [ion binding]; other site
568206014202	Pirin-related protein [General function prediction only]; Region: COG1741
568206014203	Pirin; Region: Pirin; pfam02678
568206014204	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568206014205	MarR family; Region: MarR_2; pfam12802
568206014206	Protein of unknown function (DUF3920); Region: DUF3920; pfam13058
568206014207	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
568206014208	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
568206014209	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
568206014210	TrkA-C domain; Region: TrkA_C; pfam02080
568206014211	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
568206014212	amino acid carrier protein; Region: agcS; TIGR00835
568206014213	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
568206014214	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
568206014215	dimerization interface [polypeptide binding]; other site
568206014216	DPS ferroxidase diiron center [ion binding]; other site
568206014217	ion pore; other site
568206014218	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
568206014219	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
568206014220	metal binding site [ion binding]; metal-binding site
568206014221	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
568206014222	Ferritin-like domain; Region: Ferritin; pfam00210
568206014223	ferroxidase diiron center [ion binding]; other site
568206014224	Predicted membrane protein [Function unknown]; Region: COG2311
568206014225	Protein of unknown function (DUF418); Region: DUF418; pfam04235
568206014226	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
568206014227	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
568206014228	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
568206014229	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
568206014230	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
568206014231	Nucleoside recognition; Region: Gate; pfam07670
568206014232	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
568206014233	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
568206014234	amino acid carrier protein; Region: agcS; TIGR00835
568206014235	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
568206014236	amino acid carrier protein; Region: agcS; TIGR00835
568206014237	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
568206014238	NADH(P)-binding; Region: NAD_binding_10; pfam13460
568206014239	NAD binding site [chemical binding]; other site
568206014240	substrate binding site [chemical binding]; other site
568206014241	putative active site [active]
568206014242	Viral enhancin protein; Region: Enhancin; pfam03272
568206014243	Peptidase M60-like family; Region: M60-like; pfam13402
568206014244	TQXA domain; Region: TQXA_dom; TIGR03934
568206014245	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568206014246	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568206014247	active site
568206014248	catalytic tetrad [active]
568206014249	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568206014250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206014251	putative substrate translocation pore; other site
568206014252	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206014253	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206014254	dimerization interface [polypeptide binding]; other site
568206014255	putative DNA binding site [nucleotide binding]; other site
568206014256	putative Zn2+ binding site [ion binding]; other site
568206014257	Uncharacterized conserved protein [Function unknown]; Region: COG2427
568206014258	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
568206014259	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206014260	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
568206014261	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
568206014262	active site
568206014263	HIGH motif; other site
568206014264	dimer interface [polypeptide binding]; other site
568206014265	KMSKS motif; other site
568206014266	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568206014267	RNA binding surface [nucleotide binding]; other site
568206014268	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436
568206014269	FAD binding domain; Region: FAD_binding_4; pfam01565
568206014270	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
568206014271	SET domain; Region: SET; pfam00856
568206014272	Domain of unknown function (DUF4077); Region: DUF4077; pfam13295
568206014273	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206014274	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206014275	dimer interface [polypeptide binding]; other site
568206014276	putative CheW interface [polypeptide binding]; other site
568206014277	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
568206014278	putative phosphate binding site [ion binding]; other site
568206014279	camphor resistance protein CrcB; Provisional; Region: PRK14219
568206014280	camphor resistance protein CrcB; Provisional; Region: PRK14205
568206014281	Protein of unknown function (DUF3947); Region: DUF3947; pfam13135
568206014282	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
568206014283	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568206014284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568206014285	Coenzyme A binding pocket [chemical binding]; other site
568206014286	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
568206014287	Nuclease-related domain; Region: NERD; pfam08378
568206014288	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
568206014289	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568206014290	Walker A/P-loop; other site
568206014291	ATP binding site [chemical binding]; other site
568206014292	Q-loop/lid; other site
568206014293	ABC transporter signature motif; other site
568206014294	Walker B; other site
568206014295	D-loop; other site
568206014296	H-loop/switch region; other site
568206014297	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206014298	ABC-ATPase subunit  interface; other site
568206014299	dimer interface [polypeptide binding]; other site
568206014300	putative PBP binding regions; other site
568206014301	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206014302	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206014303	ABC-ATPase subunit  interface; other site
568206014304	dimer interface [polypeptide binding]; other site
568206014305	putative PBP binding regions; other site
568206014306	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
568206014307	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
568206014308	putative ligand binding residues [chemical binding]; other site
568206014309	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206014310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206014311	active site
568206014312	phosphorylation site [posttranslational modification]
568206014313	intermolecular recognition site; other site
568206014314	dimerization interface [polypeptide binding]; other site
568206014315	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206014316	DNA binding site [nucleotide binding]
568206014317	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
568206014318	SmpB-tmRNA interface; other site
568206014319	ribonuclease R; Region: RNase_R; TIGR02063
568206014320	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
568206014321	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
568206014322	RNB domain; Region: RNB; pfam00773
568206014323	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
568206014324	RNA binding site [nucleotide binding]; other site
568206014325	Esterase/lipase [General function prediction only]; Region: COG1647
568206014326	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
568206014327	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
568206014328	holin-like protein; Validated; Region: PRK01658
568206014329	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
568206014330	active site
568206014331	NUMOD4 motif; Region: NUMOD4; pfam07463
568206014332	HNH endonuclease; Region: HNH_3; pfam13392
568206014333	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
568206014334	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
568206014335	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
568206014336	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
568206014337	active site
568206014338	Phage-related protein [Function unknown]; Region: COG4695; cl01923
568206014339	Phage portal protein; Region: Phage_portal; pfam04860
568206014340	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
568206014341	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
568206014342	Phage capsid family; Region: Phage_capsid; pfam05065
568206014343	Phage capsid family; Region: Phage_capsid; pfam05065
568206014344	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
568206014345	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
568206014346	active site
568206014347	DNA binding site [nucleotide binding]
568206014348	Int/Topo IB signature motif; other site
568206014349	enolase; Provisional; Region: eno; PRK00077
568206014350	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
568206014351	dimer interface [polypeptide binding]; other site
568206014352	metal binding site [ion binding]; metal-binding site
568206014353	substrate binding pocket [chemical binding]; other site
568206014354	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
568206014355	phosphoglyceromutase; Provisional; Region: PRK05434
568206014356	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
568206014357	triosephosphate isomerase; Provisional; Region: PRK14565
568206014358	substrate binding site [chemical binding]; other site
568206014359	dimer interface [polypeptide binding]; other site
568206014360	catalytic triad [active]
568206014361	Phosphoglycerate kinase; Region: PGK; pfam00162
568206014362	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
568206014363	substrate binding site [chemical binding]; other site
568206014364	hinge regions; other site
568206014365	ADP binding site [chemical binding]; other site
568206014366	catalytic site [active]
568206014367	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
568206014368	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
568206014369	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
568206014370	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568206014371	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568206014372	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
568206014373	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
568206014374	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
568206014375	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
568206014376	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
568206014377	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
568206014378	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
568206014379	stage V sporulation protein AD; Provisional; Region: PRK12404
568206014380	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
568206014381	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
568206014382	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
568206014383	Predicted membrane protein [Function unknown]; Region: COG2323
568206014384	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
568206014385	Clp protease; Region: CLP_protease; pfam00574
568206014386	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
568206014387	oligomer interface [polypeptide binding]; other site
568206014388	active site residues [active]
568206014389	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
568206014390	dimerization domain swap beta strand [polypeptide binding]; other site
568206014391	regulatory protein interface [polypeptide binding]; other site
568206014392	active site
568206014393	regulatory phosphorylation site [posttranslational modification]; other site
568206014394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
568206014395	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
568206014396	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
568206014397	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
568206014398	phosphate binding site [ion binding]; other site
568206014399	putative substrate binding pocket [chemical binding]; other site
568206014400	dimer interface [polypeptide binding]; other site
568206014401	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
568206014402	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
568206014403	putative active site [active]
568206014404	nucleotide binding site [chemical binding]; other site
568206014405	nudix motif; other site
568206014406	putative metal binding site [ion binding]; other site
568206014407	Domain of unknown function (DUF368); Region: DUF368; pfam04018
568206014408	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
568206014409	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568206014410	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568206014411	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206014412	binding surface
568206014413	TPR motif; other site
568206014414	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568206014415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568206014416	binding surface
568206014417	Tetratricopeptide repeat; Region: TPR_16; pfam13432
568206014418	TPR motif; other site
568206014419	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
568206014420	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
568206014421	trimer interface [polypeptide binding]; other site
568206014422	active site
568206014423	substrate binding site [chemical binding]; other site
568206014424	CoA binding site [chemical binding]; other site
568206014425	pyrophosphatase PpaX; Provisional; Region: PRK13288
568206014426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206014427	active site
568206014428	motif I; other site
568206014429	motif II; other site
568206014430	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
568206014431	HPr kinase/phosphorylase; Provisional; Region: PRK05428
568206014432	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
568206014433	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
568206014434	Hpr binding site; other site
568206014435	active site
568206014436	homohexamer subunit interaction site [polypeptide binding]; other site
568206014437	Predicted membrane protein [Function unknown]; Region: COG1950
568206014438	Domain of unknown function (DUF4275); Region: DUF4275; pfam14101
568206014439	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
568206014440	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
568206014441	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
568206014442	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
568206014443	excinuclease ABC subunit B; Provisional; Region: PRK05298
568206014444	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206014445	ATP binding site [chemical binding]; other site
568206014446	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206014447	nucleotide binding region [chemical binding]; other site
568206014448	ATP-binding site [chemical binding]; other site
568206014449	Ultra-violet resistance protein B; Region: UvrB; pfam12344
568206014450	Probable transposase; Region: OrfB_IS605; pfam01385
568206014451	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
568206014452	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
568206014453	Domain of unknown function (DUF4362); Region: DUF4362; pfam14275
568206014454	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
568206014455	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206014456	DNA binding residues [nucleotide binding]
568206014457	dimer interface [polypeptide binding]; other site
568206014458	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
568206014459	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206014460	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206014461	non-specific DNA binding site [nucleotide binding]; other site
568206014462	salt bridge; other site
568206014463	sequence-specific DNA binding site [nucleotide binding]; other site
568206014464	Predicted membrane protein [Function unknown]; Region: COG2855
568206014465	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206014466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206014467	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
568206014468	putative dimerization interface [polypeptide binding]; other site
568206014469	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
568206014470	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568206014471	DNA binding residues [nucleotide binding]
568206014472	putative dimer interface [polypeptide binding]; other site
568206014473	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
568206014474	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568206014475	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
568206014476	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206014477	ABC transporter; Region: ABC_tran_2; pfam12848
568206014478	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206014479	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568206014480	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
568206014481	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568206014482	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568206014483	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
568206014484	Walker A/P-loop; other site
568206014485	ATP binding site [chemical binding]; other site
568206014486	Q-loop/lid; other site
568206014487	ABC transporter signature motif; other site
568206014488	Walker B; other site
568206014489	D-loop; other site
568206014490	H-loop/switch region; other site
568206014491	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
568206014492	protein binding site [polypeptide binding]; other site
568206014493	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
568206014494	C-terminal peptidase (prc); Region: prc; TIGR00225
568206014495	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
568206014496	protein binding site [polypeptide binding]; other site
568206014497	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
568206014498	Catalytic dyad [active]
568206014499	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
568206014500	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
568206014501	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
568206014502	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206014503	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
568206014504	Walker A/P-loop; other site
568206014505	ATP binding site [chemical binding]; other site
568206014506	Q-loop/lid; other site
568206014507	ABC transporter signature motif; other site
568206014508	Walker B; other site
568206014509	D-loop; other site
568206014510	H-loop/switch region; other site
568206014511	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
568206014512	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
568206014513	peptide chain release factor 2; Provisional; Region: PRK06746
568206014514	This domain is found in peptide chain release factors; Region: PCRF; smart00937
568206014515	RF-1 domain; Region: RF-1; pfam00472
568206014516	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
568206014517	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
568206014518	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
568206014519	nucleotide binding region [chemical binding]; other site
568206014520	ATP-binding site [chemical binding]; other site
568206014521	SEC-C motif; Region: SEC-C; pfam02810
568206014522	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
568206014523	30S subunit binding site; other site
568206014524	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568206014525	DNA-binding site [nucleotide binding]; DNA binding site
568206014526	RNA-binding motif; other site
568206014527	comF family protein; Region: comF; TIGR00201
568206014528	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206014529	active site
568206014530	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
568206014531	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206014532	ATP binding site [chemical binding]; other site
568206014533	putative Mg++ binding site [ion binding]; other site
568206014534	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206014535	nucleotide binding region [chemical binding]; other site
568206014536	ATP-binding site [chemical binding]; other site
568206014537	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
568206014538	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
568206014539	NlpC/P60 family; Region: NLPC_P60; pfam00877
568206014540	Predicted transcriptional regulators [Transcription]; Region: COG1733
568206014541	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568206014542	dimerization interface [polypeptide binding]; other site
568206014543	putative DNA binding site [nucleotide binding]; other site
568206014544	putative Zn2+ binding site [ion binding]; other site
568206014545	EDD domain protein, DegV family; Region: DegV; TIGR00762
568206014546	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
568206014547	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
568206014548	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
568206014549	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
568206014550	Transcriptional regulator [Transcription]; Region: LytR; COG1316
568206014551	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
568206014552	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
568206014553	active site
568206014554	homodimer interface [polypeptide binding]; other site
568206014555	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
568206014556	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
568206014557	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
568206014558	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
568206014559	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
568206014560	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
568206014561	Mg++ binding site [ion binding]; other site
568206014562	putative catalytic motif [active]
568206014563	substrate binding site [chemical binding]; other site
568206014564	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568206014565	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
568206014566	NodB motif; other site
568206014567	active site
568206014568	catalytic site [active]
568206014569	Zn binding site [ion binding]; other site
568206014570	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568206014571	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
568206014572	Walker A motif; other site
568206014573	ATP binding site [chemical binding]; other site
568206014574	Walker B motif; other site
568206014575	arginine finger; other site
568206014576	Transcriptional antiterminator [Transcription]; Region: COG3933
568206014577	PRD domain; Region: PRD; pfam00874
568206014578	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
568206014579	active pocket/dimerization site; other site
568206014580	active site
568206014581	phosphorylation site [posttranslational modification]
568206014582	PRD domain; Region: PRD; pfam00874
568206014583	A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754
568206014584	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
568206014585	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
568206014586	Chromate transporter; Region: Chromate_transp; pfam02417
568206014587	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
568206014588	putative active site [active]
568206014589	YdjC motif; other site
568206014590	Mg binding site [ion binding]; other site
568206014591	putative homodimer interface [polypeptide binding]; other site
568206014592	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
568206014593	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
568206014594	NAD binding site [chemical binding]; other site
568206014595	sugar binding site [chemical binding]; other site
568206014596	divalent metal binding site [ion binding]; other site
568206014597	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568206014598	dimer interface [polypeptide binding]; other site
568206014599	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568206014600	active site
568206014601	methionine cluster; other site
568206014602	phosphorylation site [posttranslational modification]
568206014603	metal binding site [ion binding]; metal-binding site
568206014604	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568206014605	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568206014606	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568206014607	active site
568206014608	P-loop; other site
568206014609	phosphorylation site [posttranslational modification]
568206014610	spermidine synthase; Provisional; Region: PRK03612
568206014611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206014612	S-adenosylmethionine binding site [chemical binding]; other site
568206014613	S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706
568206014614	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568206014615	methionine cluster; other site
568206014616	active site
568206014617	phosphorylation site [posttranslational modification]
568206014618	metal binding site [ion binding]; metal-binding site
568206014619	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568206014620	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
568206014621	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568206014622	active site
568206014623	P-loop; other site
568206014624	phosphorylation site [posttranslational modification]
568206014625	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
568206014626	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
568206014627	Acyltransferase family; Region: Acyl_transf_3; pfam01757
568206014628	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
568206014629	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568206014630	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
568206014631	Predicted membrane protein [Function unknown]; Region: COG1511
568206014632	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568206014633	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
568206014634	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
568206014635	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568206014636	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568206014637	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
568206014638	putative dimerization interface [polypeptide binding]; other site
568206014639	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
568206014640	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
568206014641	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
568206014642	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
568206014643	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
568206014644	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
568206014645	transmembrane helices; other site
568206014646	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
568206014647	ThiC-associated domain; Region: ThiC-associated; pfam13667
568206014648	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
568206014649	L-lactate permease; Region: Lactate_perm; cl00701
568206014650	glycolate transporter; Provisional; Region: PRK09695
568206014651	Tic20-like protein; Region: Tic20; pfam09685
568206014652	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
568206014653	Uncharacterized conserved protein [Function unknown]; Region: COG3339
568206014654	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
568206014655	Sulfatase; Region: Sulfatase; pfam00884
568206014656	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
568206014657	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
568206014658	homodimer interface [polypeptide binding]; other site
568206014659	substrate-cofactor binding pocket; other site
568206014660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206014661	catalytic residue [active]
568206014662	Bacterial SH3 domain; Region: SH3_3; cl17532
568206014663	Bacterial SH3 domain; Region: SH3_3; cl17532
568206014664	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206014665	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206014666	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
568206014667	NlpC/P60 family; Region: NLPC_P60; pfam00877
568206014668	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
568206014669	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
568206014670	Nucleoside recognition; Region: Gate; pfam07670
568206014671	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
568206014672	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
568206014673	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
568206014674	DXD motif; other site
568206014675	BCCT family transporter; Region: BCCT; pfam02028
568206014676	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206014677	Bacterial SH3 domain; Region: SH3_3; pfam08239
568206014678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
568206014679	Protein of unknown function (DUF3910); Region: DUF3910; pfam13049
568206014680	Predicted membrane protein [Function unknown]; Region: COG4640
568206014681	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
568206014682	Double zinc ribbon; Region: DZR; pfam12773
568206014683	Double zinc ribbon; Region: DZR; pfam12773
568206014684	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
568206014685	SNF2 Helicase protein; Region: DUF3670; pfam12419
568206014686	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
568206014687	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568206014688	ATP binding site [chemical binding]; other site
568206014689	putative Mg++ binding site [ion binding]; other site
568206014690	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
568206014691	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206014692	nucleotide binding region [chemical binding]; other site
568206014693	ATP-binding site [chemical binding]; other site
568206014694	Predicted integral membrane protein [Function unknown]; Region: COG5652
568206014695	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
568206014696	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
568206014697	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
568206014698	ComK protein; Region: ComK; pfam06338
568206014699	RNA polymerase factor sigma-70; Validated; Region: PRK06759
568206014700	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206014701	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206014702	DNA binding residues [nucleotide binding]
568206014703	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
568206014704	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568206014705	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568206014706	FtsX-like permease family; Region: FtsX; pfam02687
568206014707	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568206014708	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568206014709	Walker A/P-loop; other site
568206014710	ATP binding site [chemical binding]; other site
568206014711	Q-loop/lid; other site
568206014712	ABC transporter signature motif; other site
568206014713	Walker B; other site
568206014714	D-loop; other site
568206014715	H-loop/switch region; other site
568206014716	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
568206014717	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
568206014718	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568206014719	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206014720	non-specific DNA binding site [nucleotide binding]; other site
568206014721	salt bridge; other site
568206014722	sequence-specific DNA binding site [nucleotide binding]; other site
568206014723	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
568206014724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206014725	putative substrate translocation pore; other site
568206014726	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
568206014727	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
568206014728	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
568206014729	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
568206014730	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568206014731	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206014732	dimerization interface [polypeptide binding]; other site
568206014733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206014734	dimer interface [polypeptide binding]; other site
568206014735	phosphorylation site [posttranslational modification]
568206014736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206014737	ATP binding site [chemical binding]; other site
568206014738	Mg2+ binding site [ion binding]; other site
568206014739	G-X-G motif; other site
568206014740	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206014741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206014742	active site
568206014743	phosphorylation site [posttranslational modification]
568206014744	intermolecular recognition site; other site
568206014745	dimerization interface [polypeptide binding]; other site
568206014746	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206014747	DNA binding site [nucleotide binding]
568206014748	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
568206014749	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
568206014750	NAD binding site [chemical binding]; other site
568206014751	homodimer interface [polypeptide binding]; other site
568206014752	active site
568206014753	substrate binding site [chemical binding]; other site
568206014754	membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379
568206014755	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
568206014756	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
568206014757	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
568206014758	active site
568206014759	homodimer interface [polypeptide binding]; other site
568206014760	teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545
568206014761	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
568206014762	Walker A/P-loop; other site
568206014763	ATP binding site [chemical binding]; other site
568206014764	Q-loop/lid; other site
568206014765	ABC transporter signature motif; other site
568206014766	Walker B; other site
568206014767	D-loop; other site
568206014768	H-loop/switch region; other site
568206014769	Bacterial SH3 domain homologues; Region: SH3b; smart00287
568206014770	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
568206014771	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
568206014772	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
568206014773	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
568206014774	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
568206014775	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
568206014776	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206014777	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568206014778	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206014779	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568206014780	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
568206014781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
568206014782	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
568206014783	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568206014784	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206014785	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
568206014786	putative glycosyl transferase; Provisional; Region: PRK10307
568206014787	rod shape-determining protein Mbl; Provisional; Region: PRK13928
568206014788	MreB and similar proteins; Region: MreB_like; cd10225
568206014789	nucleotide binding site [chemical binding]; other site
568206014790	Mg binding site [ion binding]; other site
568206014791	putative protofilament interaction site [polypeptide binding]; other site
568206014792	RodZ interaction site [polypeptide binding]; other site
568206014793	Stage III sporulation protein D; Region: SpoIIID; cl17560
568206014794	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
568206014795	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568206014796	Peptidase family M23; Region: Peptidase_M23; pfam01551
568206014797	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
568206014798	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
568206014799	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206014800	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206014801	Walker A/P-loop; other site
568206014802	ATP binding site [chemical binding]; other site
568206014803	Q-loop/lid; other site
568206014804	ABC transporter signature motif; other site
568206014805	Walker B; other site
568206014806	D-loop; other site
568206014807	H-loop/switch region; other site
568206014808	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
568206014809	LytTr DNA-binding domain; Region: LytTR; pfam04397
568206014810	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568206014811	Walker A/P-loop; other site
568206014812	ATP binding site [chemical binding]; other site
568206014813	ABC transporter; Region: ABC_tran; pfam00005
568206014814	Q-loop/lid; other site
568206014815	ABC transporter signature motif; other site
568206014816	Walker B; other site
568206014817	D-loop; other site
568206014818	Stage II sporulation protein; Region: SpoIID; pfam08486
568206014819	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
568206014820	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
568206014821	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
568206014822	hinge; other site
568206014823	active site
568206014824	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
568206014825	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
568206014826	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
568206014827	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
568206014828	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
568206014829	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
568206014830	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
568206014831	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
568206014832	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
568206014833	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
568206014834	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
568206014835	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
568206014836	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
568206014837	4Fe-4S binding domain; Region: Fer4; cl02805
568206014838	4Fe-4S binding domain; Region: Fer4; pfam00037
568206014839	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
568206014840	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
568206014841	NADH dehydrogenase subunit D; Provisional; Region: PRK12322
568206014842	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
568206014843	NADH dehydrogenase subunit C; Validated; Region: PRK07735
568206014844	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
568206014845	NADH dehydrogenase subunit B; Validated; Region: PRK06411
568206014846	NADH dehydrogenase subunit A; Validated; Region: PRK07756
568206014847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206014848	PAS domain; Region: PAS_9; pfam13426
568206014849	putative active site [active]
568206014850	heme pocket [chemical binding]; other site
568206014851	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568206014852	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206014853	metal binding site [ion binding]; metal-binding site
568206014854	active site
568206014855	I-site; other site
568206014856	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568206014857	Protein of unknown function (DUF975); Region: DUF975; cl10504
568206014858	Protein of unknown function (DUF975); Region: DUF975; cl10504
568206014859	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
568206014860	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
568206014861	gamma subunit interface [polypeptide binding]; other site
568206014862	epsilon subunit interface [polypeptide binding]; other site
568206014863	LBP interface [polypeptide binding]; other site
568206014864	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
568206014865	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
568206014866	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
568206014867	alpha subunit interaction interface [polypeptide binding]; other site
568206014868	Walker A motif; other site
568206014869	ATP binding site [chemical binding]; other site
568206014870	Walker B motif; other site
568206014871	inhibitor binding site; inhibition site
568206014872	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568206014873	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
568206014874	core domain interface [polypeptide binding]; other site
568206014875	delta subunit interface [polypeptide binding]; other site
568206014876	epsilon subunit interface [polypeptide binding]; other site
568206014877	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
568206014878	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
568206014879	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
568206014880	beta subunit interaction interface [polypeptide binding]; other site
568206014881	Walker A motif; other site
568206014882	ATP binding site [chemical binding]; other site
568206014883	Walker B motif; other site
568206014884	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568206014885	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
568206014886	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
568206014887	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
568206014888	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
568206014889	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
568206014890	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
568206014891	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
568206014892	ATP synthase I chain; Region: ATP_synt_I; pfam03899
568206014893	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
568206014894	Protein of unknown function (DUF4024); Region: DUF4024; pfam13216
568206014895	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568206014896	active site
568206014897	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
568206014898	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
568206014899	dimer interface [polypeptide binding]; other site
568206014900	active site
568206014901	glycine-pyridoxal phosphate binding site [chemical binding]; other site
568206014902	folate binding site [chemical binding]; other site
568206014903	hypothetical protein; Provisional; Region: PRK13690
568206014904	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
568206014905	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
568206014906	Low molecular weight phosphatase family; Region: LMWPc; cd00115
568206014907	active site
568206014908	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
568206014909	HPr interaction site; other site
568206014910	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568206014911	active site
568206014912	phosphorylation site [posttranslational modification]
568206014913	Predicted membrane protein [Function unknown]; Region: COG2259
568206014914	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
568206014915	Protein of unknown function (DUF3935); Region: DUF3935; pfam13071
568206014916	Predicted membrane protein [Function unknown]; Region: COG1971
568206014917	Domain of unknown function DUF; Region: DUF204; pfam02659
568206014918	Domain of unknown function DUF; Region: DUF204; pfam02659
568206014919	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
568206014920	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
568206014921	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568206014922	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
568206014923	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
568206014924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206014925	S-adenosylmethionine binding site [chemical binding]; other site
568206014926	peptide chain release factor 1; Validated; Region: prfA; PRK00591
568206014927	This domain is found in peptide chain release factors; Region: PCRF; smart00937
568206014928	RF-1 domain; Region: RF-1; pfam00472
568206014929	thymidine kinase; Provisional; Region: PRK04296
568206014930	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
568206014931	transcription termination factor Rho; Provisional; Region: rho; PRK09376
568206014932	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
568206014933	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
568206014934	RNA binding site [nucleotide binding]; other site
568206014935	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
568206014936	multimer interface [polypeptide binding]; other site
568206014937	Walker A motif; other site
568206014938	ATP binding site [chemical binding]; other site
568206014939	Walker B motif; other site
568206014940	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
568206014941	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
568206014942	putative active site [active]
568206014943	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
568206014944	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
568206014945	hinge; other site
568206014946	active site
568206014947	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
568206014948	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
568206014949	intersubunit interface [polypeptide binding]; other site
568206014950	active site
568206014951	zinc binding site [ion binding]; other site
568206014952	Na+ binding site [ion binding]; other site
568206014953	Response regulator receiver domain; Region: Response_reg; pfam00072
568206014954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206014955	active site
568206014956	phosphorylation site [posttranslational modification]
568206014957	intermolecular recognition site; other site
568206014958	dimerization interface [polypeptide binding]; other site
568206014959	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
568206014960	CTP synthetase; Validated; Region: pyrG; PRK05380
568206014961	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
568206014962	Catalytic site [active]
568206014963	active site
568206014964	UTP binding site [chemical binding]; other site
568206014965	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
568206014966	active site
568206014967	putative oxyanion hole; other site
568206014968	catalytic triad [active]
568206014969	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
568206014970	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206014971	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206014972	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
568206014973	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
568206014974	FAD binding site [chemical binding]; other site
568206014975	homotetramer interface [polypeptide binding]; other site
568206014976	substrate binding pocket [chemical binding]; other site
568206014977	catalytic base [active]
568206014978	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
568206014979	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
568206014980	FAD binding site [chemical binding]; other site
568206014981	homotetramer interface [polypeptide binding]; other site
568206014982	substrate binding pocket [chemical binding]; other site
568206014983	catalytic base [active]
568206014984	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
568206014985	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
568206014986	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
568206014987	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
568206014988	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
568206014989	dimer interface [polypeptide binding]; other site
568206014990	active site
568206014991	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
568206014992	4Fe-4S binding domain; Region: Fer4; cl02805
568206014993	Cysteine-rich domain; Region: CCG; pfam02754
568206014994	Cysteine-rich domain; Region: CCG; pfam02754
568206014995	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568206014996	PLD-like domain; Region: PLDc_2; pfam13091
568206014997	putative active site [active]
568206014998	catalytic site [active]
568206014999	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568206015000	PLD-like domain; Region: PLDc_2; pfam13091
568206015001	putative active site [active]
568206015002	catalytic site [active]
568206015003	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
568206015004	Domain of unknown function (DUF4084); Region: DUF4084; pfam13321
568206015005	PAS domain S-box; Region: sensory_box; TIGR00229
568206015006	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206015007	putative active site [active]
568206015008	heme pocket [chemical binding]; other site
568206015009	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568206015010	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206015011	metal binding site [ion binding]; metal-binding site
568206015012	active site
568206015013	I-site; other site
568206015014	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568206015015	Bacillus PapR protein; Region: Bacillus_PapR; pfam05968
568206015016	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568206015017	non-specific DNA binding site [nucleotide binding]; other site
568206015018	salt bridge; other site
568206015019	sequence-specific DNA binding site [nucleotide binding]; other site
568206015020	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568206015021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206015022	active site
568206015023	phosphorylation site [posttranslational modification]
568206015024	intermolecular recognition site; other site
568206015025	dimerization interface [polypeptide binding]; other site
568206015026	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
568206015027	DNA binding residues [nucleotide binding]
568206015028	dimerization interface [polypeptide binding]; other site
568206015029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
568206015030	Histidine kinase; Region: HisKA_3; pfam07730
568206015031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206015032	ATP binding site [chemical binding]; other site
568206015033	Mg2+ binding site [ion binding]; other site
568206015034	G-X-G motif; other site
568206015035	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
568206015036	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
568206015037	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206015038	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568206015039	Walker A/P-loop; other site
568206015040	ATP binding site [chemical binding]; other site
568206015041	Q-loop/lid; other site
568206015042	ABC transporter signature motif; other site
568206015043	Walker B; other site
568206015044	D-loop; other site
568206015045	H-loop/switch region; other site
568206015046	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
568206015047	active site
568206015048	Collagen binding domain; Region: Collagen_bind; pfam05737
568206015049	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568206015050	Collagen binding domain; Region: Collagen_bind; pfam05737
568206015051	Collagen binding domain; Region: Collagen_bind; pfam05737
568206015052	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015053	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015054	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015055	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015056	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015057	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015058	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568206015059	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015060	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015061	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015062	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568206015063	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015064	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015065	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015066	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015067	Cna protein B-type domain; Region: Cna_B; pfam05738
568206015068	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
568206015069	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
568206015070	PA/protease or protease-like domain interface [polypeptide binding]; other site
568206015071	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
568206015072	Peptidase family M28; Region: Peptidase_M28; pfam04389
568206015073	metal binding site [ion binding]; metal-binding site
568206015074	RNA polymerase sigma factor; Provisional; Region: PRK12522
568206015075	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568206015076	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568206015077	DNA binding residues [nucleotide binding]
568206015078	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
568206015079	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
568206015080	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
568206015081	active site
568206015082	HIGH motif; other site
568206015083	KMSK motif region; other site
568206015084	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
568206015085	tRNA binding surface [nucleotide binding]; other site
568206015086	anticodon binding site; other site
568206015087	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
568206015088	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
568206015089	putative dimer interface [polypeptide binding]; other site
568206015090	catalytic triad [active]
568206015091	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
568206015092	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
568206015093	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
568206015094	agmatinase; Region: agmatinase; TIGR01230
568206015095	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
568206015096	putative active site [active]
568206015097	Mn binding site [ion binding]; other site
568206015098	spermidine synthase; Provisional; Region: PRK00811
568206015099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206015100	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206015101	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568206015102	putative substrate translocation pore; other site
568206015103	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568206015104	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
568206015105	DNA binding residues [nucleotide binding]
568206015106	putative dimer interface [polypeptide binding]; other site
568206015107	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
568206015108	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
568206015109	active site
568206015110	catalytic site [active]
568206015111	metal binding site [ion binding]; metal-binding site
568206015112	dimer interface [polypeptide binding]; other site
568206015113	Transglycosylase; Region: Transgly; pfam00912
568206015114	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568206015115	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568206015116	YwhD family; Region: YwhD; pfam08741
568206015117	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
568206015118	Peptidase family M50; Region: Peptidase_M50; pfam02163
568206015119	active site
568206015120	putative substrate binding region [chemical binding]; other site
568206015121	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
568206015122	active site 1 [active]
568206015123	dimer interface [polypeptide binding]; other site
568206015124	hexamer interface [polypeptide binding]; other site
568206015125	active site 2 [active]
568206015126	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
568206015127	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568206015128	Zn2+ binding site [ion binding]; other site
568206015129	Mg2+ binding site [ion binding]; other site
568206015130	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
568206015131	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
568206015132	intersubunit interface [polypeptide binding]; other site
568206015133	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568206015134	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568206015135	Walker A/P-loop; other site
568206015136	ATP binding site [chemical binding]; other site
568206015137	Q-loop/lid; other site
568206015138	ABC transporter signature motif; other site
568206015139	Walker B; other site
568206015140	D-loop; other site
568206015141	H-loop/switch region; other site
568206015142	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206015143	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206015144	ABC-ATPase subunit  interface; other site
568206015145	dimer interface [polypeptide binding]; other site
568206015146	putative PBP binding regions; other site
568206015147	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568206015148	dimer interface [polypeptide binding]; other site
568206015149	putative PBP binding regions; other site
568206015150	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206015151	ABC-ATPase subunit  interface; other site
568206015152	FecCD transport family; Region: FecCD; pfam01032
568206015153	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568206015154	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
568206015155	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
568206015156	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
568206015157	hypothetical protein; Provisional; Region: PRK12473
568206015158	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
568206015159	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
568206015160	putative heme peroxidase; Provisional; Region: PRK12276
568206015161	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
568206015162	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568206015163	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
568206015164	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
568206015165	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
568206015166	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
568206015167	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
568206015168	Ion channel; Region: Ion_trans_2; pfam07885
568206015169	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
568206015170	TrkA-N domain; Region: TrkA_N; pfam02254
568206015171	TrkA-C domain; Region: TrkA_C; pfam02080
568206015172	putative uracil/xanthine transporter; Provisional; Region: PRK11412
568206015173	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568206015174	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206015175	motif II; other site
568206015176	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206015177	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
568206015178	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
568206015179	ligand binding site [chemical binding]; other site
568206015180	active site
568206015181	UGI interface [polypeptide binding]; other site
568206015182	catalytic site [active]
568206015183	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
568206015184	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
568206015185	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
568206015186	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568206015187	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568206015188	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
568206015189	Walker A/P-loop; other site
568206015190	ATP binding site [chemical binding]; other site
568206015191	Q-loop/lid; other site
568206015192	ABC transporter signature motif; other site
568206015193	Walker B; other site
568206015194	D-loop; other site
568206015195	H-loop/switch region; other site
568206015196	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
568206015197	active site
568206015198	catalytic triad [active]
568206015199	oxyanion hole [active]
568206015200	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568206015201	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568206015202	DNA binding site [nucleotide binding]
568206015203	domain linker motif; other site
568206015204	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568206015205	putative dimerization interface [polypeptide binding]; other site
568206015206	putative ligand binding site [chemical binding]; other site
568206015207	Predicted membrane protein [Function unknown]; Region: COG2364
568206015208	homoserine dehydrogenase; Provisional; Region: PRK06349
568206015209	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
568206015210	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
568206015211	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
568206015212	homoserine O-succinyltransferase; Provisional; Region: PRK05368
568206015213	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
568206015214	proposed active site lysine [active]
568206015215	conserved cys residue [active]
568206015216	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702
568206015217	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568206015218	homodimer interface [polypeptide binding]; other site
568206015219	substrate-cofactor binding pocket; other site
568206015220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568206015221	catalytic residue [active]
568206015222	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
568206015223	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
568206015224	Cl- selectivity filter; other site
568206015225	Cl- binding residues [ion binding]; other site
568206015226	pore gating glutamate residue; other site
568206015227	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
568206015228	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568206015229	active site
568206015230	motif I; other site
568206015231	motif II; other site
568206015232	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
568206015233	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568206015234	ligand binding site [chemical binding]; other site
568206015235	flexible hinge region; other site
568206015236	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
568206015237	azoreductase; Provisional; Region: PRK13556
568206015238	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568206015239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206015240	active site
568206015241	phosphorylation site [posttranslational modification]
568206015242	intermolecular recognition site; other site
568206015243	dimerization interface [polypeptide binding]; other site
568206015244	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
568206015245	DNA binding residues [nucleotide binding]
568206015246	dimerization interface [polypeptide binding]; other site
568206015247	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
568206015248	Histidine kinase; Region: HisKA_3; pfam07730
568206015249	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
568206015250	ATP binding site [chemical binding]; other site
568206015251	Mg2+ binding site [ion binding]; other site
568206015252	G-X-G motif; other site
568206015253	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
568206015254	GAF domain; Region: GAF; pfam01590
568206015255	GAF domain; Region: GAF_3; pfam13492
568206015256	GAF domain; Region: GAF_2; pfam13185
568206015257	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
568206015258	dimer interface [polypeptide binding]; other site
568206015259	substrate binding site [chemical binding]; other site
568206015260	ATP binding site [chemical binding]; other site
568206015261	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
568206015262	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568206015263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568206015264	metal binding site [ion binding]; metal-binding site
568206015265	active site
568206015266	I-site; other site
568206015267	Protein of unknown function (DUF466); Region: DUF466; pfam04328
568206015268	carbon starvation protein A; Provisional; Region: PRK15015
568206015269	Carbon starvation protein CstA; Region: CstA; pfam02554
568206015270	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
568206015271	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
568206015272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206015273	active site
568206015274	phosphorylation site [posttranslational modification]
568206015275	intermolecular recognition site; other site
568206015276	dimerization interface [polypeptide binding]; other site
568206015277	LytTr DNA-binding domain; Region: LytTR; pfam04397
568206015278	benzoate transport; Region: 2A0115; TIGR00895
568206015279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206015280	putative substrate translocation pore; other site
568206015281	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
568206015282	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
568206015283	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568206015284	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
568206015285	Predicted membrane protein [Function unknown]; Region: COG2860
568206015286	UPF0126 domain; Region: UPF0126; pfam03458
568206015287	UPF0126 domain; Region: UPF0126; pfam03458
568206015288	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
568206015289	heme-binding site [chemical binding]; other site
568206015290	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
568206015291	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568206015292	dimer interface [polypeptide binding]; other site
568206015293	putative CheW interface [polypeptide binding]; other site
568206015294	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
568206015295	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
568206015296	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
568206015297	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
568206015298	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
568206015299	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568206015300	active site
568206015301	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568206015302	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206015303	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206015304	ABC transporter; Region: ABC_tran_2; pfam12848
568206015305	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568206015306	conserved hypothetical integral membrane protein; Region: TIGR03766
568206015307	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
568206015308	Predicted membrane protein [Function unknown]; Region: COG2246
568206015309	GtrA-like protein; Region: GtrA; pfam04138
568206015310	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
568206015311	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
568206015312	Ligand binding site; other site
568206015313	Putative Catalytic site; other site
568206015314	DXD motif; other site
568206015315	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568206015316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568206015317	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
568206015318	Protein export membrane protein; Region: SecD_SecF; cl14618
568206015319	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
568206015320	methionine sulfoxide reductase B; Provisional; Region: PRK00222
568206015321	SelR domain; Region: SelR; pfam01641
568206015322	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568206015323	antiholin-like protein LrgB; Provisional; Region: PRK04288
568206015324	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
568206015325	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
568206015326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206015327	active site
568206015328	phosphorylation site [posttranslational modification]
568206015329	intermolecular recognition site; other site
568206015330	dimerization interface [polypeptide binding]; other site
568206015331	LytTr DNA-binding domain; Region: LytTR; pfam04397
568206015332	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
568206015333	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
568206015334	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
568206015335	Histidine kinase; Region: His_kinase; pfam06580
568206015336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206015337	ATP binding site [chemical binding]; other site
568206015338	Mg2+ binding site [ion binding]; other site
568206015339	G-X-G motif; other site
568206015340	benzoate transport; Region: 2A0115; TIGR00895
568206015341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568206015342	putative substrate translocation pore; other site
568206015343	BCCT family transporter; Region: BCCT; pfam02028
568206015344	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
568206015345	active site
568206015346	dimer interface [polypeptide binding]; other site
568206015347	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
568206015348	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
568206015349	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
568206015350	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568206015351	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568206015352	NAD(P) binding site [chemical binding]; other site
568206015353	active site
568206015354	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
568206015355	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
568206015356	UDP-glucose 4-epimerase; Region: PLN02240
568206015357	NAD binding site [chemical binding]; other site
568206015358	homodimer interface [polypeptide binding]; other site
568206015359	active site
568206015360	substrate binding site [chemical binding]; other site
568206015361	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
568206015362	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
568206015363	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
568206015364	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
568206015365	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
568206015366	ATP binding site [chemical binding]; other site
568206015367	Mg++ binding site [ion binding]; other site
568206015368	motif III; other site
568206015369	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568206015370	nucleotide binding region [chemical binding]; other site
568206015371	ATP-binding site [chemical binding]; other site
568206015372	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
568206015373	RNA binding site [nucleotide binding]; other site
568206015374	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
568206015375	Acyltransferase family; Region: Acyl_transf_3; pfam01757
568206015376	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
568206015377	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
568206015378	active site
568206015379	oligoendopeptidase F; Region: pepF; TIGR00181
568206015380	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
568206015381	active site
568206015382	Zn binding site [ion binding]; other site
568206015383	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568206015384	FeS/SAM binding site; other site
568206015385	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
568206015386	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
568206015387	CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129
568206015388	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
568206015389	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
568206015390	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
568206015391	protein binding site [polypeptide binding]; other site
568206015392	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
568206015393	YycH protein; Region: YycI; pfam09648
568206015394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
568206015395	YycH protein; Region: YycH; pfam07435
568206015396	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
568206015397	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
568206015398	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568206015399	dimerization interface [polypeptide binding]; other site
568206015400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568206015401	putative active site [active]
568206015402	heme pocket [chemical binding]; other site
568206015403	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568206015404	dimer interface [polypeptide binding]; other site
568206015405	phosphorylation site [posttranslational modification]
568206015406	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568206015407	ATP binding site [chemical binding]; other site
568206015408	Mg2+ binding site [ion binding]; other site
568206015409	G-X-G motif; other site
568206015410	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568206015411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568206015412	active site
568206015413	phosphorylation site [posttranslational modification]
568206015414	intermolecular recognition site; other site
568206015415	dimerization interface [polypeptide binding]; other site
568206015416	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568206015417	DNA binding site [nucleotide binding]
568206015418	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
568206015419	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
568206015420	GDP-binding site [chemical binding]; other site
568206015421	ACT binding site; other site
568206015422	IMP binding site; other site
568206015423	replicative DNA helicase; Provisional; Region: PRK05748
568206015424	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
568206015425	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
568206015426	Walker A motif; other site
568206015427	ATP binding site [chemical binding]; other site
568206015428	Walker B motif; other site
568206015429	DNA binding loops [nucleotide binding]
568206015430	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
568206015431	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
568206015432	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
568206015433	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
568206015434	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
568206015435	DHH family; Region: DHH; pfam01368
568206015436	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
568206015437	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
568206015438	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
568206015439	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
568206015440	dimer interface [polypeptide binding]; other site
568206015441	ssDNA binding site [nucleotide binding]; other site
568206015442	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568206015443	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
568206015444	GTP-binding protein YchF; Reviewed; Region: PRK09601
568206015445	YchF GTPase; Region: YchF; cd01900
568206015446	G1 box; other site
568206015447	GTP/Mg2+ binding site [chemical binding]; other site
568206015448	Switch I region; other site
568206015449	G2 box; other site
568206015450	Switch II region; other site
568206015451	G3 box; other site
568206015452	G4 box; other site
568206015453	G5 box; other site
568206015454	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
568206015455	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
568206015456	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
568206015457	Mechanosensitive ion channel; Region: MS_channel; pfam00924
568206015458	putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841
568206015459	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
568206015460	ParB-like nuclease domain; Region: ParB; smart00470
568206015461	KorB domain; Region: KorB; pfam08535
568206015462	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
568206015463	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
568206015464	P-loop; other site
568206015465	Magnesium ion binding site [ion binding]; other site
568206015466	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
568206015467	Magnesium ion binding site [ion binding]; other site
568206015468	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
568206015469	ParB-like nuclease domain; Region: ParBc; pfam02195
568206015470	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
568206015471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568206015472	S-adenosylmethionine binding site [chemical binding]; other site
568206015473	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
568206015474	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
568206015475	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
568206015476	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
568206015477	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
568206015478	trmE is a tRNA modification GTPase; Region: trmE; cd04164
568206015479	G1 box; other site
568206015480	GTP/Mg2+ binding site [chemical binding]; other site
568206015481	Switch I region; other site
568206015482	G2 box; other site
568206015483	Switch II region; other site
568206015484	G3 box; other site
568206015485	G4 box; other site
568206015486	G5 box; other site
568206015487	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
568206015488	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
568206015489	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
568206015490	G-X-X-G motif; other site
568206015491	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
568206015492	RxxxH motif; other site
568206015493	OxaA-like protein precursor; Validated; Region: PRK02944
568206015494	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
568206015495	ribonuclease P; Reviewed; Region: rnpA; PRK00499
568206015496	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399